locus-tag	class	description
FPL18_RS00015	COG3209	COG3209 Rhs family protein
FPL18_RS00020	COG3501	Rhs element vgr protein
FPL18_RS00030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FPL18_RS00050	COG0531	amino acid
FPL18_RS00055	COG4303	Ethanolamine ammonia lyase large subunit
FPL18_RS00065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL18_RS00065	COG0519	Catalyzes the synthesis of GMP from XMP
FPL18_RS00080	COG1073	alpha beta
FPL18_RS00085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL18_RS00095	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL18_RS00115	COG0778	Nitroreductase
FPL18_RS00130	COG0697	spore germination
FPL18_RS00135	COG1923	regulation of RNA biosynthetic process
FPL18_RS00145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FPL18_RS00150	COG0802	atpase or kinase
FPL18_RS00185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL18_RS00190	COG3300	MHYT domain
FPL18_RS00190	COG5001	Diguanylate cyclase
FPL18_RS00210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FPL18_RS00215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FPL18_RS00220	COG1845	cytochrome c oxidase, subunit III
FPL18_RS00225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FPL18_RS00255	COG2249	NAD(P)H dehydrogenase (quinone) activity
FPL18_RS00260	COG1733	regulation of RNA biosynthetic process
FPL18_RS00265	COG0305	Participates in initiation and elongation during chromosome replication
FPL18_RS00270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPL18_RS00285	COG1305	Transglutaminase-like
FPL18_RS00295	COG2308	Evidence 4 Homologs of previously reported genes of
FPL18_RS00310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FPL18_RS00330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FPL18_RS00350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FPL18_RS00360	COG3038	cytochrome b561
FPL18_RS00365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FPL18_RS00370	COG2252	PERMEase
FPL18_RS00430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FPL18_RS00435	COG0138	bifunctional purine biosynthesis protein purh
FPL18_RS00445	COG1464	Belongs to the NlpA lipoprotein family
FPL18_RS00450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FPL18_RS00455	COG2011	ABC-type metal ion transport system permease component
FPL18_RS00475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL18_RS00485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FPL18_RS00490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FPL18_RS00495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPL18_RS00535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FPL18_RS00550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FPL18_RS00555	COG0571	ribonuclease III activity
FPL18_RS00570	COG0481	GTPase activity
FPL18_RS00585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL18_RS00600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FPL18_RS00605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FPL18_RS00610	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FPL18_RS00620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FPL18_RS00625	COG4208	sulfate ABC transporter
FPL18_RS00630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FPL18_RS00635	COG0583	DNA-binding transcription factor activity
FPL18_RS00650	COG0602	queuosine metabolic process
FPL18_RS00655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FPL18_RS00670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPL18_RS00685	COG1056	cytidyltransferase-related domain
FPL18_RS00685	COG1051	belongs to the nudix hydrolase family
FPL18_RS00690	COG1024	Enoyl-CoA hydratase
FPL18_RS00695	COG1929	Belongs to the glycerate kinase type-1 family
FPL18_RS00700	COG3323	Protein of unknown function (DUF1653)
FPL18_RS00700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FPL18_RS00735	COG2814	Major facilitator Superfamily
FPL18_RS00740	COG0047	phosphoribosylformylglycinamidine synthase activity
FPL18_RS00740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FPL18_RS00780	COG0824	Thioesterase
FPL18_RS00800	COG0823	Involved in the tonB-independent uptake of proteins
FPL18_RS00820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL18_RS00855	COG0628	permease
FPL18_RS00865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FPL18_RS00875	COG0616	signal peptide processing
FPL18_RS00875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FPL18_RS00885	COG2333	competence protein COMEC
FPL18_RS00885	COG0658	competence protein
FPL18_RS00890	COG4591	ABC-type transport system involved in lipoprotein release permease component
FPL18_RS00895	COG1136	(ABC) transporter
FPL18_RS00965	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FPL18_RS00970	COG1280	lysine exporter protein (LysE YggA)
FPL18_RS00975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FPL18_RS00980	COG0019	diaminopimelate decarboxylase activity
FPL18_RS00990	COG1113	amino acid transport
FPL18_RS00995	COG1115	amino acid carrier protein
FPL18_RS01010	COG0306	phosphate transporter
FPL18_RS01020	COG2852	Protein conserved in bacteria
FPL18_RS01030	COG2066	Belongs to the glutaminase family
FPL18_RS01035	COG0242	peptide deformylase activity
FPL18_RS01055	COG0589	response to stress
FPL18_RS01095	COG2175	clavaminate synthase activity
FPL18_RS01100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS01105	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FPL18_RS01110	COG4521	taurine ABC transporter
FPL18_RS01120	COG1045	serine acetyltransferase
FPL18_RS01125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL18_RS01130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FPL18_RS01150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FPL18_RS01165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS01170	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FPL18_RS01185	COG1230	cation diffusion facilitator family transporter
FPL18_RS01195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FPL18_RS01200	COG4149	molybdate abc transporter
FPL18_RS01205	COG0725	ABC transporter, periplasmic molybdate-binding protein
FPL18_RS01305	COG0671	phosphoesterase, PA-phosphatase related
FPL18_RS01315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL18_RS01325	COG3008	intermembrane lipid transfer
FPL18_RS01325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL18_RS01330	COG2995	paraquat-inducible protein a
FPL18_RS01340	COG0833	amino acid
FPL18_RS01350	COG3724	N-succinylarginine dihydrolase activity
FPL18_RS01355	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS01360	COG3138	arginine N-succinyltransferase
FPL18_RS01365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FPL18_RS01370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FPL18_RS01380	COG0281	malic enzyme
FPL18_RS01395	COG4774	siderophore transport
FPL18_RS01415	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS01425	COG0583	DNA-binding transcription factor activity
FPL18_RS01430	COG4948	Mandelate Racemase Muconate Lactonizing
FPL18_RS01435	COG4829	muconolactone delta-isomerase
FPL18_RS01445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL18_RS01450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FPL18_RS01455	COG0183	Belongs to the thiolase family
FPL18_RS01460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL18_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS01480	COG3733	amine oxidase
FPL18_RS01490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FPL18_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS01510	COG4638	Rieske (2fe-2S)
FPL18_RS01525	COG0154	amidase activity
FPL18_RS01535	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL18_RS01540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FPL18_RS01550	COG2814	Major facilitator Superfamily
FPL18_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS01610	COG1538	Outer membrane efflux protein
FPL18_RS01675	COG3209	COG3209 Rhs family protein
FPL18_RS01695	COG3209	COG3209 Rhs family protein
FPL18_RS01700	COG3501	Rhs element vgr protein
FPL18_RS01705	COG4774	siderophore transport
FPL18_RS01710	COG4607	ABC-type enterochelin transport system periplasmic component
FPL18_RS01715	COG4604	ABC transporter, ATP-binding protein
FPL18_RS01720	COG4605	iron ion homeostasis
FPL18_RS01725	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FPL18_RS01740	COG1309	transcriptional regulator
FPL18_RS01750	COG0789	Transcriptional regulator
FPL18_RS01760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL18_RS01765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL18_RS01780	COG2072	flavoprotein involved in K transport
FPL18_RS01785	COG0300	oxidoreductase activity
FPL18_RS01800	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL18_RS01800	COG1902	pentaerythritol trinitrate reductase activity
FPL18_RS01805	COG4689	acetoacetate decarboxylase
FPL18_RS01810	COG0300	oxidoreductase activity
FPL18_RS01820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL18_RS01825	COG0235	Class ii aldolase
FPL18_RS01830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL18_RS01865	COG1401	restriction endodeoxyribonuclease activity
FPL18_RS01880	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FPL18_RS01885	COG0583	DNA-binding transcription factor activity
FPL18_RS01900	COG0583	DNA-binding transcription factor activity
FPL18_RS01905	COG1053	succinate dehydrogenase
FPL18_RS01940	COG4221	oxidoreductase activity
FPL18_RS01945	COG0778	Nitroreductase
FPL18_RS01960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL18_RS01965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL18_RS01980	COG1560	Kdo2-lipid A biosynthetic process
FPL18_RS01995	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
FPL18_RS02030	COG0583	DNA-binding transcription factor activity
FPL18_RS02035	COG1073	alpha beta
FPL18_RS02055	COG2814	Major facilitator Superfamily
FPL18_RS02060	COG1566	PFAM secretion protein HlyD family protein
FPL18_RS02075	COG0543	2 iron, 2 sulfur cluster binding
FPL18_RS02075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FPL18_RS02080	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FPL18_RS02085	COG4638	Rieske (2fe-2S)
FPL18_RS02090	COG2050	protein possibly involved in aromatic compounds catabolism
FPL18_RS02100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL18_RS02105	COG1090	epimerase
FPL18_RS02120	COG1024	Enoyl-CoA hydratase
FPL18_RS02125	COG0420	3'-5' exonuclease activity
FPL18_RS02135	COG1011	Hydrolase
FPL18_RS02165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL18_RS02190	COG0121	glutamine amidotransferase
FPL18_RS02210	COG0756	dUTP diphosphatase activity
FPL18_RS02215	COG0210	DNA helicase
FPL18_RS02220	COG2885	chlorophyll binding
FPL18_RS02225	COG0204	Acyl-transferase
FPL18_RS02235	COG0850	regulation of cytokinetic process
FPL18_RS02240	COG2894	cell division
FPL18_RS02245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FPL18_RS02255	COG1674	ftsk spoiiie
FPL18_RS02260	COG0492	ferredoxin-NADP+ reductase activity
FPL18_RS02265	COG0500	methyltransferase
FPL18_RS02270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FPL18_RS02280	COG0456	acetyltransferase
FPL18_RS02300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FPL18_RS02345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FPL18_RS02345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL18_RS02370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPL18_RS02395	COG0564	pseudouridine synthase activity
FPL18_RS02405	COG0358	DNA primase activity
FPL18_RS02420	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FPL18_RS02450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPL18_RS02485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FPL18_RS02495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FPL18_RS02495	COG0351	phosphomethylpyrimidine kinase
FPL18_RS02495	COG0352	thiamine-phosphate diphosphorylase activity
FPL18_RS02500	COG1652	LysM domain
FPL18_RS02510	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS02520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FPL18_RS02525	COG1399	metal-binding, possibly nucleic acid-binding protein
FPL18_RS02530	COG3101	peptidyl-lysine hydroxylation
FPL18_RS02535	COG0009	L-threonylcarbamoyladenylate synthase
FPL18_RS02550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FPL18_RS02555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FPL18_RS02580	COG0339	signal peptide processing
FPL18_RS02590	COG4166	transmembrane transport
FPL18_RS02630	COG4106	trans-aconitate 2-methyltransferase activity
FPL18_RS02640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FPL18_RS02640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FPL18_RS02645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL18_RS02645	COG2226	methyltransferase
FPL18_RS02645	COG0596	Alpha beta hydrolase
FPL18_RS02655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPL18_RS02660	COG0583	DNA-binding transcription factor activity
FPL18_RS02665	COG4638	Rieske (2fe-2S)
FPL18_RS02670	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FPL18_RS02675	COG0633	Ferredoxin
FPL18_RS02675	COG0543	2 iron, 2 sulfur cluster binding
FPL18_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS02685	COG3135	benzoate transporter
FPL18_RS02690	COG2814	Major facilitator Superfamily
FPL18_RS02710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FPL18_RS02720	COG1196	nuclear chromosome segregation
FPL18_RS02740	COG0730	response to heat
FPL18_RS02760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FPL18_RS02770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL18_RS02795	COG0644	oxidoreductase
FPL18_RS02845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FPL18_RS02850	COG0489	protein tyrosine kinase activity
FPL18_RS02885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL18_RS02885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL18_RS02895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL18_RS02905	COG4716	Myosin-crossreactive antigen
FPL18_RS02920	COG2226	methyltransferase
FPL18_RS02945	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FPL18_RS02950	COG2081	HI0933 family
FPL18_RS02960	COG0668	transmembrane transport
FPL18_RS02985	COG0583	DNA-binding transcription factor activity
FPL18_RS02990	COG4774	siderophore transport
FPL18_RS03010	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL18_RS03015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL18_RS03020	COG0713	ATP synthesis coupled electron transport
FPL18_RS03030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL18_RS03045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FPL18_RS03055	COG0649	NAD binding
FPL18_RS03055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL18_RS03065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPL18_RS03070	COG3706	GGDEF domain
FPL18_RS03080	COG2205	protein histidine kinase activity
FPL18_RS03085	COG0745	RESPONSE REGULATOR receiver
FPL18_RS03105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FPL18_RS03115	COG1309	transcriptional regulator
FPL18_RS03125	COG1309	transcriptional regulator
FPL18_RS03145	COG3555	Aspartyl Asparaginyl beta-hydroxylase
FPL18_RS03160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FPL18_RS03195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL18_RS03200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL18_RS03205	COG1309	transcriptional regulator
FPL18_RS03225	COG1063	alcohol dehydrogenase
FPL18_RS03230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPL18_RS03295	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FPL18_RS03300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FPL18_RS03305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FPL18_RS03330	COG2132	Multicopper oxidase
FPL18_RS03340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FPL18_RS03370	COG1968	undecaprenyl-diphosphatase activity
FPL18_RS03375	COG1214	PFAM Peptidase M22, glycoprotease
FPL18_RS03385	COG0494	nUDIX hydrolase
FPL18_RS03425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPL18_RS03435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FPL18_RS03445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FPL18_RS03450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FPL18_RS03515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPL18_RS03525	COG1846	Transcriptional regulator
FPL18_RS03530	COG1764	response to oxidative stress
FPL18_RS03555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL18_RS03555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPL18_RS03560	COG2755	lipolytic protein G-D-S-L family
FPL18_RS03560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FPL18_RS03575	COG0037	tRNA processing
FPL18_RS03585	COG0248	Ppx GppA phosphatase
FPL18_RS03610	COG0072	phenylalanine-tRNA ligase activity
FPL18_RS03645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FPL18_RS03660	COG1238	metal cluster binding
FPL18_RS03675	COG0625	glutathione transferase activity
FPL18_RS03695	COG0318	PFAM AMP-dependent synthetase and ligase
FPL18_RS03700	COG3028	Belongs to the UPF0307 family
FPL18_RS03725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FPL18_RS03730	COG0617	tRNA 3'-terminal CCA addition
FPL18_RS03735	COG1555	photosystem II stabilization
FPL18_RS03740	COG3956	TIGRFAM MazG family protein
FPL18_RS03770	COG5002	protein histidine kinase activity
FPL18_RS03770	COG2205	protein histidine kinase activity
FPL18_RS03770	COG0784	Response regulator, receiver
FPL18_RS03785	COG2084	Dehydrogenase
FPL18_RS03790	COG3622	Belongs to the hyi family
FPL18_RS03810	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FPL18_RS03815	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL18_RS03820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FPL18_RS03830	COG2814	Major facilitator Superfamily
FPL18_RS03840	COG2890	protein-(glutamine-N5) methyltransferase activity
FPL18_RS03865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPL18_RS03880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FPL18_RS03895	COG0084	hydrolase, TatD family'
FPL18_RS03900	COG0726	polysaccharide deacetylase
FPL18_RS03910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FPL18_RS03945	COG0583	DNA-binding transcription factor activity
FPL18_RS03985	COG0431	NADPH-dependent FMN reductase
FPL18_RS03990	COG0798	PFAM Bile acid sodium symporter
FPL18_RS03995	COG0640	Transcriptional regulator
FPL18_RS04015	COG1476	TRANSCRIPTIONal
FPL18_RS04040	COG0440	acetolactate synthase activity
FPL18_RS04045	COG0028	Belongs to the TPP enzyme family
FPL18_RS04065	COG1466	dna polymerase III delta subunit
FPL18_RS04070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FPL18_RS04075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL18_RS04080	COG0577	efflux transmembrane transporter activity
FPL18_RS04080	COG1136	(ABC) transporter
FPL18_RS04085	COG1538	Outer membrane efflux protein
FPL18_RS04105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FPL18_RS04110	COG1162	GTPase activity
FPL18_RS04120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FPL18_RS04160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FPL18_RS04170	COG3781	membrane
FPL18_RS04175	COG0667	Aldo Keto reductase
FPL18_RS04180	COG0583	DNA-binding transcription factor activity
FPL18_RS04185	COG0613	PHP domain protein
FPL18_RS04215	COG1666	GTP binding
FPL18_RS04230	COG1956	GAF domain-containing protein
FPL18_RS04235	COG1607	acyl-coa hydrolase
FPL18_RS04250	COG3453	Protein conserved in bacteria
FPL18_RS04250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL18_RS04290	COG1183	phosphatidylcholine synthase activity
FPL18_RS04295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FPL18_RS04325	COG0739	heme binding
FPL18_RS04325	COG0741	lytic transglycosylase activity
FPL18_RS04325	COG1196	nuclear chromosome segregation
FPL18_RS04335	COG1702	phosphate starvation-inducible protein PhoH
FPL18_RS04350	COG4773	Receptor
FPL18_RS04375	COG3878	Protein conserved in bacteria
FPL18_RS04380	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FPL18_RS04420	COG0788	formyltetrahydrofolate deformylase activity
FPL18_RS04435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FPL18_RS04440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FPL18_RS04445	COG4651	solute:proton antiporter activity
FPL18_RS04445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL18_RS04470	COG0724	RNA recognition motif
FPL18_RS04475	COG0210	DNA helicase
FPL18_RS04500	COG1733	regulation of RNA biosynthetic process
FPL18_RS04525	COG1560	Kdo2-lipid A biosynthetic process
FPL18_RS04600	COG0473	3-isopropylmalate dehydrogenase activity
FPL18_RS04615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FPL18_RS04625	COG0583	DNA-binding transcription factor activity
FPL18_RS04650	COG0494	nUDIX hydrolase
FPL18_RS04665	COG0753	catalase activity
FPL18_RS04685	COG0583	DNA-binding transcription factor activity
FPL18_RS04690	COG0625	glutathione transferase activity
FPL18_RS04715	COG1530	ribonuclease E activity
FPL18_RS04735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPL18_RS04745	COG0534	Mate efflux family protein
FPL18_RS04750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL18_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS04785	COG1309	transcriptional regulator
FPL18_RS04790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FPL18_RS04815	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FPL18_RS04820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPL18_RS04835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FPL18_RS04845	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FPL18_RS04845	COG0644	oxidoreductase
FPL18_RS04850	COG0425	Belongs to the sulfur carrier protein TusA family
FPL18_RS04855	COG4535	Mg2 and Co2 transporter CorC
FPL18_RS04860	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FPL18_RS04865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPL18_RS04890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FPL18_RS04900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FPL18_RS04915	COG0789	Transcriptional regulator
FPL18_RS04920	COG0598	Magnesium transport protein CorA
FPL18_RS04925	COG1301	dicarboxylic acid transport
FPL18_RS04930	COG1185	polyribonucleotide nucleotidyltransferase activity
FPL18_RS04935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FPL18_RS04945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FPL18_RS04950	COG1074	ATP-dependent DNA helicase activity
FPL18_RS04955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FPL18_RS04980	COG2226	methyltransferase
FPL18_RS04990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPL18_RS04995	COG3038	cytochrome b561
FPL18_RS05010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPL18_RS05020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FPL18_RS05025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FPL18_RS05025	COG2111	Na H antiporter
FPL18_RS05030	COG1006	Multisubunit Na H antiporter MnhC subunit
FPL18_RS05035	COG0651	ATP synthesis coupled electron transport
FPL18_RS05045	COG2212	antiporter activity
FPL18_RS05055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FPL18_RS05065	COG0195	Participates in both transcription termination and antitermination
FPL18_RS05090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FPL18_RS05115	COG0237	dephospho-CoA kinase activity
FPL18_RS05125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPL18_RS05135	COG0497	DNA recombination
FPL18_RS05145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FPL18_RS05175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL18_RS05230	COG1132	(ABC) transporter
FPL18_RS05240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FPL18_RS05260	COG0326	Molecular chaperone. Has ATPase activity
FPL18_RS05275	COG2056	Na+-H+ antiporter family
FPL18_RS05320	COG0081	regulation of translation
FPL18_RS05325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FPL18_RS05375	COG0546	phosphoglycolate phosphatase activity
FPL18_RS05380	COG1716	ATPase activity
FPL18_RS05425	COG0181	hydroxymethylbilane synthase activity
FPL18_RS05435	COG3275	phosphorelay sensor kinase activity
FPL18_RS05470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FPL18_RS05475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPL18_RS05485	COG0772	Belongs to the SEDS family
FPL18_RS05510	COG4974	Belongs to the 'phage' integrase family
FPL18_RS05515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL18_RS05525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FPL18_RS05535	COG2197	response regulator
FPL18_RS05550	COG0793	Belongs to the peptidase S41A family
FPL18_RS05555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FPL18_RS05560	COG0795	lipopolysaccharide-transporting ATPase activity
FPL18_RS05565	COG0795	lipopolysaccharide-transporting ATPase activity
FPL18_RS05600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL18_RS05600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPL18_RS05610	COG0004	ammonium transporteR
FPL18_RS05615	COG0347	Belongs to the P(II) protein family
FPL18_RS05650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FPL18_RS05665	COG0318	PFAM AMP-dependent synthetase and ligase
FPL18_RS05680	COG2860	membrane
FPL18_RS05690	COG1253	flavin adenine dinucleotide binding
FPL18_RS05710	COG2814	Major facilitator Superfamily
FPL18_RS05720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPL18_RS05725	COG0745	RESPONSE REGULATOR receiver
FPL18_RS05730	COG2205	protein histidine kinase activity
FPL18_RS05735	COG4452	Inner membrane protein CreD
FPL18_RS05765	COG2814	Major facilitator Superfamily
FPL18_RS05785	COG0655	NAD(P)H dehydrogenase (quinone) activity
FPL18_RS05805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FPL18_RS05840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPL18_RS05860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPL18_RS05865	COG3162	membrane
FPL18_RS05870	COG2205	protein histidine kinase activity
FPL18_RS05870	COG0784	Response regulator, receiver
FPL18_RS05900	COG1652	LysM domain
FPL18_RS05905	COG0758	DNA mediated transformation
FPL18_RS05970	COG1309	transcriptional regulator
FPL18_RS05975	COG2814	Major facilitator Superfamily
FPL18_RS05990	COG0386	Belongs to the glutathione peroxidase family
FPL18_RS06000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FPL18_RS06005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FPL18_RS06015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FPL18_RS06055	COG1121	(ABC) transporter
FPL18_RS06060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FPL18_RS06065	COG1280	lysine exporter protein (LysE YggA)
FPL18_RS06070	COG2837	iron assimilation
FPL18_RS06110	COG0735	belongs to the Fur family
FPL18_RS06125	COG2271	Major facilitator Superfamily
FPL18_RS06165	COG0519	Catalyzes the synthesis of GMP from XMP
FPL18_RS06165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPL18_RS06170	COG4399	Belongs to the UPF0754 family
FPL18_RS06175	COG3111	PFAM Bacterial OB fold (BOF) protein
FPL18_RS06180	COG2259	Doxx family
FPL18_RS06185	COG0586	Pfam SNARE associated Golgi protein
FPL18_RS06200	COG1192	Involved in chromosome partitioning
FPL18_RS06210	COG0271	Belongs to the BolA IbaG family
FPL18_RS06230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL18_RS06245	COG1113	amino acid transport
FPL18_RS06250	COG0697	spore germination
FPL18_RS06255	COG0477	Major facilitator Superfamily
FPL18_RS06265	COG1024	Enoyl-CoA hydratase
FPL18_RS06270	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS06275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FPL18_RS06295	COG1113	amino acid transport
FPL18_RS06300	COG0251	oxidation-reduction process
FPL18_RS06315	COG1522	sequence-specific DNA binding
FPL18_RS06370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FPL18_RS06375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FPL18_RS06405	COG0456	acetyltransferase
FPL18_RS06410	COG0564	pseudouridine synthase activity
FPL18_RS06465	COG4456	Virulence-associated protein
FPL18_RS06475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FPL18_RS06490	COG1802	Transcriptional regulator
FPL18_RS06495	COG1448	Aminotransferase
FPL18_RS06500	COG0277	FAD linked oxidase domain protein
FPL18_RS06510	COG2186	Transcriptional regulator
FPL18_RS06520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPL18_RS06525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FPL18_RS06540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FPL18_RS06545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FPL18_RS06555	COG0438	transferase activity, transferring glycosyl groups
FPL18_RS06565	COG0438	transferase activity, transferring glycosyl groups
FPL18_RS06570	COG1442	glycosyl transferase family 8
FPL18_RS06570	COG1216	Glycosyl transferase, family 2
FPL18_RS06580	COG1596	polysaccharide export
FPL18_RS06605	COG0728	peptidoglycan biosynthetic process
FPL18_RS06610	COG3023	N-Acetylmuramoyl-L-alanine amidase
FPL18_RS06670	COG0546	phosphoglycolate phosphatase activity
FPL18_RS06675	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS06685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FPL18_RS06685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FPL18_RS06690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL18_RS06695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL18_RS06700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL18_RS06705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS06710	COG1116	anion transmembrane transporter activity
FPL18_RS06715	COG1309	transcriptional regulator
FPL18_RS06725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FPL18_RS06735	COG0196	riboflavin kinase activity
FPL18_RS06740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FPL18_RS06750	COG1047	Peptidyl-prolyl cis-trans
FPL18_RS06790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FPL18_RS06810	COG0583	DNA-binding transcription factor activity
FPL18_RS06820	COG0443	Heat shock 70 kDa protein
FPL18_RS06825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FPL18_RS06855	COG2951	lytic endotransglycosylase activity
FPL18_RS06860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FPL18_RS06880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPL18_RS06905	COG0583	DNA-binding transcription factor activity
FPL18_RS06915	COG0861	Integral membrane protein TerC family
FPL18_RS06925	COG0402	S-adenosylhomocysteine deaminase activity
FPL18_RS06940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL18_RS06955	COG0706	membrane insertase activity
FPL18_RS06970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FPL18_RS06980	COG0592	DNA-directed DNA polymerase activity
FPL18_RS06990	COG0187	DNA topoisomerase II activity
FPL18_RS06995	COG0586	Pfam SNARE associated Golgi protein
FPL18_RS07000	COG0488	(ABC) transporter
FPL18_RS07030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FPL18_RS07035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FPL18_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS07095	COG0733	neurotransmitter:sodium symporter activity
FPL18_RS07135	COG0583	DNA-binding transcription factor activity
FPL18_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS07155	COG1309	transcriptional regulator
FPL18_RS07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL18_RS07190	COG2814	Major facilitator Superfamily
FPL18_RS07195	COG0656	L-ascorbic acid biosynthetic process
FPL18_RS07200	COG0583	DNA-binding transcription factor activity
FPL18_RS07210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL18_RS07215	COG1064	alcohol dehydrogenase
FPL18_RS07220	COG2818	Glycosylase
FPL18_RS07245	COG5487	UPF0391 membrane protein
FPL18_RS07250	COG2983	Belongs to the UPF0260 family
FPL18_RS07255	COG2133	pyrroloquinoline quinone binding
FPL18_RS07265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FPL18_RS07290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FPL18_RS07300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPL18_RS07305	COG1335	isochorismatase
FPL18_RS07310	COG1522	sequence-specific DNA binding
FPL18_RS07350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPL18_RS07360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FPL18_RS07365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FPL18_RS07370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FPL18_RS07390	COG3830	Belongs to the UPF0237 family
FPL18_RS07390	COG0560	Phosphoserine phosphatase
FPL18_RS07410	COG0753	catalase activity
FPL18_RS07440	COG2814	Major facilitator Superfamily
FPL18_RS07445	COG0583	DNA-binding transcription factor activity
FPL18_RS07450	COG1280	lysine exporter protein (LysE YggA)
FPL18_RS07455	COG0583	DNA-binding transcription factor activity
FPL18_RS07495	COG0534	Mate efflux family protein
FPL18_RS07500	COG0436	Aminotransferase
FPL18_RS07505	COG2733	membrane
FPL18_RS07520	COG2918	glutathione biosynthetic process
FPL18_RS07530	COG3501	Rhs element vgr protein
FPL18_RS07535	COG3409	Peptidoglycan-binding domain 1 protein
FPL18_RS07535	COG5632	N-Acetylmuramoyl-L-alanine amidase
FPL18_RS07535	COG1388	LysM domain
FPL18_RS07565	COG3150	esterase
FPL18_RS07580	COG0559	Belongs to the binding-protein-dependent transport system permease family
FPL18_RS07595	COG0410	ABC transporter
FPL18_RS07620	COG0666	response to abiotic stimulus
FPL18_RS07620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FPL18_RS07655	COG1393	Belongs to the ArsC family
FPL18_RS07660	COG0708	Exodeoxyribonuclease III
FPL18_RS07670	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPL18_RS07695	COG0300	oxidoreductase activity
FPL18_RS07710	COG1846	Transcriptional regulator
FPL18_RS07715	COG0386	Belongs to the glutathione peroxidase family
FPL18_RS07720	COG0189	ligase activity
FPL18_RS07740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FPL18_RS07785	COG2119	membrane
FPL18_RS07790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FPL18_RS07790	COG0426	domain, Protein
FPL18_RS07820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FPL18_RS07840	COG1902	pentaerythritol trinitrate reductase activity
FPL18_RS07845	COG1519	Transferase
FPL18_RS07850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPL18_RS07855	COG0668	transmembrane transport
FPL18_RS07865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FPL18_RS07870	COG1335	isochorismatase
FPL18_RS07875	COG1522	sequence-specific DNA binding
FPL18_RS07915	COG1113	amino acid transport
FPL18_RS07925	COG1522	sequence-specific DNA binding
FPL18_RS07930	COG3706	GGDEF domain
FPL18_RS07940	COG1309	transcriptional regulator
FPL18_RS07955	COG0351	phosphomethylpyrimidine kinase
FPL18_RS07955	COG0352	thiamine-phosphate diphosphorylase activity
FPL18_RS07955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FPL18_RS07965	COG2814	Major facilitator Superfamily
FPL18_RS07975	COG1335	isochorismatase
FPL18_RS07980	COG0583	DNA-binding transcription factor activity
FPL18_RS07990	COG1335	isochorismatase
FPL18_RS08000	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FPL18_RS08060	COG3158	transport of potassium into the cell
FPL18_RS08075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FPL18_RS08090	COG0107	imidazoleglycerol-phosphate synthase activity
FPL18_RS08135	COG0659	secondary active sulfate transmembrane transporter activity
FPL18_RS08155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FPL18_RS08185	COG0427	acetyl-CoA hydrolase
FPL18_RS08190	COG2205	protein histidine kinase activity
FPL18_RS08195	COG0745	RESPONSE REGULATOR receiver
FPL18_RS08240	COG0583	DNA-binding transcription factor activity
FPL18_RS08245	COG2851	Citrate transporter
FPL18_RS08255	COG0477	Major facilitator Superfamily
FPL18_RS08260	COG0789	Transcriptional regulator
FPL18_RS08265	COG3320	Male sterility
FPL18_RS08265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL18_RS08270	COG4221	oxidoreductase activity
FPL18_RS08280	COG0488	(ABC) transporter
FPL18_RS08345	COG0833	amino acid
FPL18_RS08370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FPL18_RS08380	COG3116	cell division
FPL18_RS08390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPL18_RS08395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FPL18_RS08405	COG2226	methyltransferase
FPL18_RS08455	COG0067	glutamate synthase
FPL18_RS08455	COG0070	glutamate synthase
FPL18_RS08455	COG0069	glutamate synthase activity
FPL18_RS08460	COG0493	'glutamate synthase
FPL18_RS08475	COG1704	LemA family
FPL18_RS08480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FPL18_RS08505	COG3307	-O-antigen
FPL18_RS08515	COG2906	2 iron, 2 sulfur cluster binding
FPL18_RS08525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL18_RS08535	COG0194	GDP metabolic process
FPL18_RS08540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FPL18_RS08610	COG0228	four-way junction DNA binding
FPL18_RS08615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FPL18_RS08625	COG0335	large ribosomal subunit rRNA binding
FPL18_RS08630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FPL18_RS08645	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FPL18_RS08650	COG3052	prosthetic group binding
FPL18_RS08670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FPL18_RS08695	COG5006	permease, DMT superfamily
FPL18_RS08700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPL18_RS08705	COG0277	FAD linked oxidase domain protein
FPL18_RS08735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FPL18_RS08740	COG2249	NAD(P)H dehydrogenase (quinone) activity
FPL18_RS08760	COG1289	transmembrane transporter activity
FPL18_RS08770	COG0628	permease
FPL18_RS08775	COG1192	Involved in chromosome partitioning
FPL18_RS08785	COG2226	methyltransferase
FPL18_RS08820	COG1404	Belongs to the peptidase S8 family
FPL18_RS08860	COG0471	metal ion transport
FPL18_RS08875	COG0517	IMP dehydrogenase activity
FPL18_RS08880	COG1983	PspC domain protein
FPL18_RS08890	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS08945	COG1127	ABC transporter
FPL18_RS08950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPL18_RS08955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPL18_RS08960	COG2854	intermembrane phospholipid transfer
FPL18_RS08985	COG0494	nUDIX hydrolase
FPL18_RS08990	COG1040	competence protein
FPL18_RS08995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FPL18_RS09010	COG2937	Belongs to the GPAT DAPAT family
FPL18_RS09015	COG1946	Acyl-CoA thioesterase
FPL18_RS09020	COG1301	dicarboxylic acid transport
FPL18_RS09035	COG1959	2 iron, 2 sulfur cluster binding
FPL18_RS09040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FPL18_RS09040	COG1017	nitric oxide dioxygenase activity
FPL18_RS09045	COG0433	COG0433 Predicted ATPase
FPL18_RS09065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FPL18_RS09085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FPL18_RS09110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FPL18_RS09135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FPL18_RS09150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FPL18_RS09170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FPL18_RS09180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FPL18_RS09185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FPL18_RS09195	COG0203	ribosomal protein L17
FPL18_RS09215	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS09220	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FPL18_RS09285	COG0339	signal peptide processing
FPL18_RS09295	COG0557	exoribonuclease II activity
FPL18_RS09320	COG3180	Ammonia monooxygenase
FPL18_RS09370	COG0179	Fumarylacetoacetate (FAA) hydrolase
FPL18_RS09385	COG1295	ribonuclease BN
FPL18_RS09410	COG1785	Belongs to the alkaline phosphatase family
FPL18_RS09465	COG2813	Specifically methylates the guanine in position
FPL18_RS09465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL18_RS09475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FPL18_RS09485	COG4774	siderophore transport
FPL18_RS09490	COG4771	TonB-dependent receptor
FPL18_RS09500	COG0740	serine-type endopeptidase activity
FPL18_RS09530	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FPL18_RS09530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FPL18_RS09550	COG0280	phosphate acetyltransferase
FPL18_RS09550	COG0857	belongs to the CobB CobQ family
FPL18_RS09555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FPL18_RS09590	COG0583	DNA-binding transcription factor activity
FPL18_RS09620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FPL18_RS09630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL18_RS09635	COG1408	metallophosphoesterase
FPL18_RS09645	COG2199	diguanylate cyclase activity
FPL18_RS09695	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS09715	COG1309	transcriptional regulator
FPL18_RS09730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FPL18_RS09735	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS09755	COG3568	Endonuclease Exonuclease Phosphatase
FPL18_RS09785	COG2969	positive regulation of protein catabolic process
FPL18_RS09790	COG0625	glutathione transferase activity
FPL18_RS09800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FPL18_RS09805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FPL18_RS09820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FPL18_RS09825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FPL18_RS09830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FPL18_RS09885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL18_RS09910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPL18_RS09925	COG1216	Glycosyl transferase, family 2
FPL18_RS09935	COG2986	histidine ammonia-lyase
FPL18_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS09980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPL18_RS09995	COG1953	Uracil, thiamine, allantoin
FPL18_RS10005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPL18_RS10015	COG1862	Preprotein translocase
FPL18_RS10050	COG5002	protein histidine kinase activity
FPL18_RS10055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FPL18_RS10140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FPL18_RS10195	COG0583	DNA-binding transcription factor activity
FPL18_RS10200	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS10205	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS10215	COG2205	protein histidine kinase activity
FPL18_RS10220	COG0745	RESPONSE REGULATOR receiver
FPL18_RS10240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FPL18_RS10260	COG2096	Adenosyltransferase
FPL18_RS10275	COG0133	tryptophan synthase activity
FPL18_RS10325	COG0285	dihydrofolate synthase activity
FPL18_RS10345	COG0450	alkyl hydroperoxide reductase
FPL18_RS10365	COG0477	Major facilitator Superfamily
FPL18_RS10370	COG1272	protein, Hemolysin III
FPL18_RS10405	COG0183	Belongs to the thiolase family
FPL18_RS10425	COG2207	Transcriptional regulator
FPL18_RS10430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FPL18_RS10445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL18_RS10460	COG0183	Belongs to the thiolase family
FPL18_RS10470	COG2885	chlorophyll binding
FPL18_RS10470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FPL18_RS10475	COG2885	chlorophyll binding
FPL18_RS10475	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FPL18_RS10480	COG1690	Belongs to the RtcB family
FPL18_RS10485	COG0833	amino acid
FPL18_RS10495	COG2233	PERMEase
FPL18_RS10525	COG4772	TonB-dependent receptor
FPL18_RS10535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FPL18_RS10550	COG0354	folic acid binding
FPL18_RS10565	COG3189	MarR family transcriptional regulator
FPL18_RS10570	COG2824	Alkylphosphonate utilization operon protein PhnA
FPL18_RS10575	COG3422	double-strand break repair
FPL18_RS10605	COG0840	transmembrane signaling receptor activity
FPL18_RS10620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FPL18_RS10625	COG5510	response to toxic substance
FPL18_RS10635	COG2832	Protein of unknown function (DUF454)
FPL18_RS10640	COG1376	ErfK ybiS ycfS ynhG family protein
FPL18_RS10720	COG1289	transmembrane transporter activity
FPL18_RS10725	COG2814	Major facilitator Superfamily
FPL18_RS10740	COG0786	glutamate:sodium symporter activity
FPL18_RS10745	COG1115	amino acid carrier protein
FPL18_RS10750	COG1752	Esterase of the alpha-beta hydrolase superfamily
FPL18_RS10755	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FPL18_RS10760	COG3590	peptidase
FPL18_RS10820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FPL18_RS10830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FPL18_RS10835	COG1077	Cell shape determining protein MreB Mrl
FPL18_RS10840	COG1792	Involved in formation and maintenance of cell shape
FPL18_RS10850	COG0424	maF-like protein
FPL18_RS10855	COG1530	ribonuclease E activity
FPL18_RS10865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FPL18_RS10875	COG0560	Phosphoserine phosphatase
FPL18_RS10890	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FPL18_RS10895	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FPL18_RS10900	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FPL18_RS10905	COG2205	protein histidine kinase activity
FPL18_RS10910	COG0745	RESPONSE REGULATOR receiver
FPL18_RS10935	COG2207	Transcriptional regulator
FPL18_RS10940	COG2851	Citrate transporter
FPL18_RS10950	COG0671	phosphoesterase, PA-phosphatase related
FPL18_RS10955	COG0174	glutamine synthetase
FPL18_RS10965	COG1113	amino acid transport
FPL18_RS10975	COG0142	geranyltranstransferase activity
FPL18_RS10980	COG2315	Protein conserved in bacteria
FPL18_RS10995	COG1752	Esterase of the alpha-beta hydrolase superfamily
FPL18_RS11015	COG2194	sulfuric ester hydrolase activity
FPL18_RS11020	COG0745	RESPONSE REGULATOR receiver
FPL18_RS11025	COG0642	Histidine kinase
FPL18_RS11040	COG1126	abc transporter atp-binding protein
FPL18_RS11045	COG0765	amino acid transport
FPL18_RS11050	COG0765	amino acid transport
FPL18_RS11060	COG0004	ammonium transporteR
FPL18_RS11065	COG2031	fatty acid transporter
FPL18_RS11080	COG0583	DNA-binding transcription factor activity
FPL18_RS11085	COG2610	gluconate transmembrane transporter activity
FPL18_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS11110	COG2852	Protein conserved in bacteria
FPL18_RS11115	COG0525	valine-tRNA ligase activity
FPL18_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS11140	COG0393	Putative heavy-metal-binding
FPL18_RS11145	COG0393	Putative heavy-metal-binding
FPL18_RS11150	COG1538	Outer membrane efflux protein
FPL18_RS11160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL18_RS11165	COG0671	phosphoesterase, PA-phosphatase related
FPL18_RS11195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FPL18_RS11210	COG1648	precorrin-2 dehydrogenase activity
FPL18_RS11210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FPL18_RS11215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FPL18_RS11225	COG1733	regulation of RNA biosynthetic process
FPL18_RS11245	COG0531	amino acid
FPL18_RS11260	COG0321	lipoyl(octanoyl) transferase activity
FPL18_RS11265	COG2921	Belongs to the UPF0250 family
FPL18_RS11285	COG1280	lysine exporter protein (LysE YggA)
FPL18_RS11295	COG0586	Pfam SNARE associated Golgi protein
FPL18_RS11320	COG2009	succinate dehydrogenase
FPL18_RS11325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FPL18_RS11330	COG1053	succinate dehydrogenase
FPL18_RS11335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FPL18_RS11355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL18_RS11375	COG2268	Band 7 protein
FPL18_RS11380	COG1585	Membrane protein implicated in regulation of membrane protease activity
FPL18_RS11390	COG2354	Protein conserved in bacteria
FPL18_RS11395	COG2321	neutral zinc metallopeptidase
FPL18_RS11415	COG2843	Capsule synthesis protein
FPL18_RS11430	COG0589	response to stress
FPL18_RS11435	COG0110	maltose O-acetyltransferase activity
FPL18_RS11455	COG0505	Belongs to the CarA family
FPL18_RS11480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FPL18_RS11485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FPL18_RS11495	COG2304	oxidoreductase activity
FPL18_RS11500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FPL18_RS11515	COG0697	spore germination
FPL18_RS11525	COG0584	glycerophosphoryl diester phosphodiesterase
FPL18_RS11540	COG2239	Acts as a magnesium transporter
FPL18_RS11550	COG0501	Belongs to the peptidase M48B family
FPL18_RS11555	COG0741	lytic transglycosylase activity
FPL18_RS11575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPL18_RS11590	COG1279	arginine transmembrane transporter activity
FPL18_RS11600	COG0583	DNA-binding transcription factor activity
FPL18_RS11620	COG1607	acyl-coa hydrolase
FPL18_RS11630	COG0523	cobalamin synthesis protein
FPL18_RS11635	COG4681	YaeQ
FPL18_RS11650	COG1649	PFAM Uncharacterised BCR, COG1649
FPL18_RS11650	COG0726	polysaccharide deacetylase
FPL18_RS11655	COG1215	transferase activity, transferring glycosyl groups
FPL18_RS11695	COG2388	GCN5-related N-acetyl-transferase
FPL18_RS11705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FPL18_RS11735	COG1597	lipid kinase activity
FPL18_RS11780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL18_RS11800	COG4771	TonB-dependent receptor
FPL18_RS11815	COG0288	reversible hydration of carbon dioxide
FPL18_RS11830	COG4181	ATPase activity
FPL18_RS11835	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FPL18_RS11840	COG0705	Rhomboid family
FPL18_RS11840	COG0457	Tetratricopeptide repeat
FPL18_RS11880	COG1215	transferase activity, transferring glycosyl groups
FPL18_RS11895	COG0415	Belongs to the DNA photolyase family
FPL18_RS11905	COG1252	NADH dehydrogenase
FPL18_RS11910	COG1686	Belongs to the peptidase S11 family
FPL18_RS11920	COG2351	hydroxyisourate hydrolase activity
FPL18_RS11945	COG1187	pseudouridine synthase activity
FPL18_RS11975	COG0612	Peptidase, M16
FPL18_RS11990	COG3025	triphosphatase activity
FPL18_RS12005	COG0352	thiamine-phosphate diphosphorylase activity
FPL18_RS12020	COG0564	pseudouridine synthase activity
FPL18_RS12030	COG0783	Belongs to the Dps family
FPL18_RS12040	COG1309	transcriptional regulator
FPL18_RS12070	COG4772	TonB-dependent receptor
FPL18_RS12075	COG4772	TonB-dependent receptor
FPL18_RS12085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FPL18_RS12090	COG0076	glutamate decarboxylase activity
FPL18_RS12100	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS12105	COG1522	sequence-specific DNA binding
FPL18_RS12110	COG3961	Belongs to the TPP enzyme family
FPL18_RS12115	COG1113	amino acid transport
FPL18_RS12125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FPL18_RS12130	COG0573	inorganic phosphate transmembrane transporter activity
FPL18_RS12140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FPL18_RS12145	COG0616	signal peptide processing
FPL18_RS12170	COG0742	ribosomal rna small subunit methyltransferase
FPL18_RS12175	COG0768	penicillin binding
FPL18_RS12200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FPL18_RS12205	COG2878	Part of a membrane complex involved in electron transport
FPL18_RS12210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FPL18_RS12220	COG3384	dioxygenase
FPL18_RS12235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FPL18_RS12305	COG0006	proline dipeptidase activity
FPL18_RS12310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL18_RS12315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL18_RS12370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL18_RS12375	COG0741	lytic transglycosylase activity
FPL18_RS12375	COG1388	LysM domain
FPL18_RS12380	COG4166	transmembrane transport
FPL18_RS12385	COG4174	ABC transporter (Permease)
FPL18_RS12390	COG4239	(ABC) transporter, permease
FPL18_RS12395	COG4172	Belongs to the ABC transporter superfamily
FPL18_RS12410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FPL18_RS12420	COG4251	negative regulation of phosphorylation
FPL18_RS12420	COG2203	Gaf domain
FPL18_RS12420	COG5001	Diguanylate cyclase
FPL18_RS12420	COG3706	GGDEF domain
FPL18_RS12435	COG3739	integral membrane protein
FPL18_RS12460	COG0302	gtp cyclohydrolase
FPL18_RS12485	COG4771	TonB-dependent receptor
FPL18_RS12500	COG0512	Glutamine amidotransferase of anthranilate synthase
FPL18_RS12515	COG3161	chorismate lyase activity
FPL18_RS12520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FPL18_RS12585	COG3706	GGDEF domain
FPL18_RS12590	COG0556	nucleotide-excision repair
FPL18_RS12650	COG0583	DNA-binding transcription factor activity
FPL18_RS12655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FPL18_RS12660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL18_RS12665	COG1773	rubredoxin
FPL18_RS12675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FPL18_RS12685	COG0175	sulfate reduction
FPL18_RS12710	COG0222	ribosome binding
FPL18_RS12715	COG1253	flavin adenine dinucleotide binding
FPL18_RS12730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FPL18_RS12740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FPL18_RS12745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FPL18_RS12765	COG2223	nitrite transmembrane transporter activity
FPL18_RS12775	COG0024	Methionine aminopeptidase
FPL18_RS12780	COG0052	Belongs to the universal ribosomal protein uS2 family
FPL18_RS12790	COG3015	lipoprotein NlpE involved in copper resistance
FPL18_RS12795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FPL18_RS12825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FPL18_RS12835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FPL18_RS12845	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FPL18_RS12850	COG1137	ATPase activity
FPL18_RS12855	COG1538	Outer membrane efflux protein
FPL18_RS12895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FPL18_RS12920	COG1914	H( )-stimulated, divalent metal cation uptake system
FPL18_RS12940	COG4770	biotin carboxylase activity
FPL18_RS12950	COG1215	transferase activity, transferring glycosyl groups
FPL18_RS12975	COG1629	transport
FPL18_RS12985	COG0583	DNA-binding transcription factor activity
FPL18_RS12995	COG0583	DNA-binding transcription factor activity
FPL18_RS13020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL18_RS13030	COG0583	DNA-binding transcription factor activity
FPL18_RS13055	COG0204	Acyl-transferase
FPL18_RS13060	COG4783	chaperone-mediated protein folding
FPL18_RS13075	COG1610	YqeY-like protein
FPL18_RS13080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FPL18_RS13135	COG2815	serine threonine protein kinase
FPL18_RS13135	COG0515	serine threonine protein kinase
FPL18_RS13165	COG1396	sequence-specific DNA binding
FPL18_RS13175	COG1454	alcohol dehydrogenase
FPL18_RS13205	COG1113	amino acid transport
FPL18_RS13210	COG3501	Rhs element vgr protein
FPL18_RS13255	COG0482	sulfurtransferase activity
FPL18_RS13275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FPL18_RS13280	COG1686	Belongs to the peptidase S11 family
FPL18_RS13310	COG0583	DNA-binding transcription factor activity
FPL18_RS13315	COG1067	ATP-dependent peptidase activity
FPL18_RS13355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPL18_RS13360	COG1966	Carbon starvation protein
FPL18_RS13365	COG2879	small protein
FPL18_RS13370	COG0714	Associated with various cellular activities
FPL18_RS13395	COG1741	Belongs to the pirin family
FPL18_RS13405	COG0583	DNA-binding transcription factor activity
FPL18_RS13410	COG0697	spore germination
FPL18_RS13415	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL18_RS13415	COG1902	pentaerythritol trinitrate reductase activity
FPL18_RS13435	COG2194	sulfuric ester hydrolase activity
FPL18_RS13450	COG1570	exodeoxyribonuclease VII activity
FPL18_RS13455	COG1113	amino acid transport
FPL18_RS13460	COG2831	hemolysin activation secretion protein
FPL18_RS13465	COG3210	domain, Protein
FPL18_RS13475	COG0765	amino acid transport
FPL18_RS13490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FPL18_RS13535	COG2223	nitrite transmembrane transporter activity
FPL18_RS13545	COG3214	Protein conserved in bacteria
FPL18_RS13550	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS13560	COG0583	DNA-binding transcription factor activity
FPL18_RS13575	COG1024	Enoyl-CoA hydratase
FPL18_RS13580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FPL18_RS13585	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS13590	COG1309	transcriptional regulator
FPL18_RS13595	COG0318	PFAM AMP-dependent synthetase and ligase
FPL18_RS13615	COG2814	Major facilitator Superfamily
FPL18_RS13640	COG5006	permease, DMT superfamily
FPL18_RS13645	COG1522	sequence-specific DNA binding
FPL18_RS13655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FPL18_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS13680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FPL18_RS13685	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS13690	COG0531	amino acid
FPL18_RS13695	COG2957	Belongs to the agmatine deiminase family
FPL18_RS13700	COG2076	Multidrug Resistance protein
FPL18_RS13705	COG2076	Multidrug Resistance protein
FPL18_RS13725	COG4221	oxidoreductase activity
FPL18_RS13730	COG1414	Transcriptional regulator
FPL18_RS13735	COG2146	nitrite reductase [NAD(P)H] activity
FPL18_RS13760	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL18_RS13765	COG2271	Major facilitator Superfamily
FPL18_RS13780	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS13795	COG0028	Belongs to the TPP enzyme family
FPL18_RS13810	COG2072	flavoprotein involved in K transport
FPL18_RS13820	COG2267	carboxylic ester hydrolase activity
FPL18_RS13825	COG0583	DNA-binding transcription factor activity
FPL18_RS13835	COG0590	tRNA wobble adenosine to inosine editing
FPL18_RS13840	COG2807	transmembrane transport
FPL18_RS13880	COG0308	aminopeptidase N
FPL18_RS13890	COG1714	RDD family
FPL18_RS13905	COG0475	glutathione-regulated potassium exporter activity
FPL18_RS13905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPL18_RS13910	COG3135	benzoate transporter
FPL18_RS13945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FPL18_RS13960	COG1959	2 iron, 2 sulfur cluster binding
FPL18_RS13985	COG0316	Belongs to the HesB IscA family
FPL18_RS13990	COG0822	iron-sulfur transferase activity
FPL18_RS14015	COG0776	regulation of translation
FPL18_RS14020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL18_RS14035	COG2137	regulation of response to DNA damage stimulus
FPL18_RS14045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FPL18_RS14050	COG1011	Hydrolase
FPL18_RS14080	COG0268	Binds directly to 16S ribosomal RNA
FPL18_RS14085	COG0702	epimerase
FPL18_RS14090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FPL18_RS14110	COG0183	Belongs to the thiolase family
FPL18_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS14145	COG0424	maF-like protein
FPL18_RS14170	COG0778	Nitroreductase
FPL18_RS14200	COG1286	toxin biosynthetic process
FPL18_RS14255	COG3634	alkyl hydroperoxide reductase activity
FPL18_RS14270	COG1045	serine acetyltransferase
FPL18_RS14290	COG0436	Aminotransferase
FPL18_RS14300	COG0386	Belongs to the glutathione peroxidase family
FPL18_RS14310	COG1280	lysine exporter protein (LysE YggA)
FPL18_RS14365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL18_RS14375	COG3501	Rhs element vgr protein
FPL18_RS14410	COG0012	GTP binding
FPL18_RS14415	COG2011	ABC-type metal ion transport system permease component
FPL18_RS14420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FPL18_RS14425	COG1464	Belongs to the NlpA lipoprotein family
FPL18_RS14475	COG0753	catalase activity
FPL18_RS14505	COG3539	Fimbrial protein
FPL18_RS14530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FPL18_RS14530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPL18_RS14560	COG1278	Cold shock
FPL18_RS14565	COG1278	Cold shock
FPL18_RS14570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL18_RS14580	COG3042	response to heat
FPL18_RS14600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FPL18_RS14605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FPL18_RS14625	COG2353	YceI-like domain
FPL18_RS14630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FPL18_RS14660	COG3153	acetyltransferase
FPL18_RS14685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FPL18_RS14690	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FPL18_RS14695	COG0506	proline dehydrogenase activity
FPL18_RS14695	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FPL18_RS14695	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FPL18_RS14705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPL18_RS14710	COG1027	Aspartate ammonia-lyase
FPL18_RS14715	COG3397	chitin binding
FPL18_RS14735	COG1132	(ABC) transporter
FPL18_RS14810	COG0668	transmembrane transport
FPL18_RS14815	COG3122	Protein conserved in bacteria
FPL18_RS14835	COG0640	Transcriptional regulator
FPL18_RS14855	COG2850	peptidyl-arginine hydroxylation
FPL18_RS14865	COG4245	von Willebrand factor, type A
FPL18_RS14910	COG1358	cellular component organization or biogenesis
FPL18_RS14955	COG0824	Thioesterase
FPL18_RS14960	COG1454	alcohol dehydrogenase
FPL18_RS14965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FPL18_RS14985	COG0069	glutamate synthase activity
FPL18_RS15000	COG1454	alcohol dehydrogenase
FPL18_RS15005	COG2610	gluconate transmembrane transporter activity
FPL18_RS15030	COG0625	glutathione transferase activity
FPL18_RS15040	COG1113	amino acid transport
FPL18_RS15045	COG0583	DNA-binding transcription factor activity
FPL18_RS15065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL18_RS15070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPL18_RS15070	COG0723	plastoquinol--plastocyanin reductase activity
FPL18_RS15090	COG2814	Major facilitator Superfamily
FPL18_RS15105	COG0439	Biotin carboxylase
FPL18_RS15120	COG1116	anion transmembrane transporter activity
FPL18_RS15120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL18_RS15130	COG2223	nitrite transmembrane transporter activity
FPL18_RS15135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL18_RS15135	COG2146	nitrite reductase [NAD(P)H] activity
FPL18_RS15140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FPL18_RS15145	COG0243	molybdopterin cofactor binding
FPL18_RS15155	COG0477	Major facilitator Superfamily
FPL18_RS15160	COG0583	DNA-binding transcription factor activity
FPL18_RS15170	COG2175	clavaminate synthase activity
FPL18_RS15175	COG3246	L-lysine catabolic process to acetate
FPL18_RS15180	COG2814	Major facilitator Superfamily
FPL18_RS15195	COG2855	membrane
FPL18_RS15265	COG2323	membrane
FPL18_RS15280	COG1546	Belongs to the CinA family
FPL18_RS15280	COG1058	Belongs to the CinA family
FPL18_RS15300	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS15320	COG0243	molybdopterin cofactor binding
FPL18_RS15325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FPL18_RS15340	COG0315	cyclic pyranopterin monophosphate synthase activity
FPL18_RS15340	COG0521	Mo-molybdopterin cofactor biosynthetic process
FPL18_RS15345	COG0303	'Molybdopterin
FPL18_RS15355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL18_RS15360	COG0697	spore germination
FPL18_RS15365	COG2920	part of a sulfur-relay system
FPL18_RS15380	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FPL18_RS15410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FPL18_RS15430	COG2204	response regulator
FPL18_RS15435	COG3852	Histidine kinase
FPL18_RS15450	COG0233	cytoplasmic translational termination
FPL18_RS15460	COG0575	Belongs to the CDS family
FPL18_RS15475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPL18_RS15485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL18_RS15495	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL18_RS15500	COG2207	Transcriptional regulator
FPL18_RS15505	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL18_RS15510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL18_RS15515	COG0642	Histidine kinase
FPL18_RS15520	COG0745	RESPONSE REGULATOR receiver
FPL18_RS15530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FPL18_RS15540	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS15545	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS15555	COG2814	Major facilitator Superfamily
FPL18_RS15565	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS15565	COG2030	dehydratase
FPL18_RS15570	COG3396	Phenylacetate-CoA oxygenase
FPL18_RS15575	COG3460	Phenylacetate-CoA oxygenase
FPL18_RS15580	COG3396	Phenylacetate-CoA oxygenase
FPL18_RS15585	COG2151	metal-sulfur cluster biosynthetic enzyme
FPL18_RS15590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FPL18_RS15595	COG1024	Enoyl-CoA hydratase
FPL18_RS15600	COG1024	Enoyl-CoA hydratase
FPL18_RS15605	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPL18_RS15610	COG0183	Belongs to the thiolase family
FPL18_RS15615	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FPL18_RS15620	COG3327	negative regulation of DNA-templated transcription, initiation
FPL18_RS15630	COG3284	Transcriptional regulator
FPL18_RS15650	COG1414	Transcriptional regulator
FPL18_RS15655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL18_RS15705	COG2223	nitrite transmembrane transporter activity
FPL18_RS15720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FPL18_RS15735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FPL18_RS15740	COG0588	phosphoglycerate mutase activity
FPL18_RS15760	COG4771	TonB-dependent receptor
FPL18_RS15780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPL18_RS15785	COG0730	response to heat
FPL18_RS15815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPL18_RS15860	COG0537	adenosine 5'-monophosphoramidase activity
FPL18_RS15875	COG2076	Multidrug Resistance protein
FPL18_RS15945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FPL18_RS15965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FPL18_RS15975	COG0133	tryptophan synthase activity
FPL18_RS15990	COG3706	GGDEF domain
FPL18_RS16005	COG2249	NAD(P)H dehydrogenase (quinone) activity
FPL18_RS16010	COG2207	Transcriptional regulator
FPL18_RS16015	COG4589	Belongs to the CDS family
FPL18_RS16030	COG2453	phosphatase
FPL18_RS16030	COG0671	phosphoesterase, PA-phosphatase related
FPL18_RS16035	COG2267	carboxylic ester hydrolase activity
FPL18_RS16040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPL18_RS16115	COG1196	nuclear chromosome segregation
FPL18_RS16135	COG4628	conserved protein (DUF2132)
FPL18_RS16145	COG1028	Short-chain dehydrogenase reductase Sdr
FPL18_RS16155	COG1309	transcriptional regulator
FPL18_RS16200	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FPL18_RS16210	COG4774	siderophore transport
FPL18_RS16215	COG0523	cobalamin synthesis protein
FPL18_RS16230	COG1469	GTP cyclohydrolase I activity
FPL18_RS16235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPL18_RS16245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FPL18_RS16270	COG1595	DNA-templated transcription, initiation
FPL18_RS16275	COG1346	cytolysis
FPL18_RS16280	COG1380	Effector of murein hydrolase LrgA
FPL18_RS16285	COG0583	DNA-binding transcription factor activity
FPL18_RS16290	COG0625	glutathione transferase activity
FPL18_RS16295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL18_RS16300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FPL18_RS16325	COG1271	oxidase subunit
FPL18_RS16330	COG1294	oxidase, subunit
FPL18_RS16340	COG2814	Major facilitator Superfamily
FPL18_RS16390	COG1595	DNA-templated transcription, initiation
FPL18_RS16395	COG0583	DNA-binding transcription factor activity
FPL18_RS16400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPL18_RS16410	COG0789	Transcriptional regulator
FPL18_RS16425	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL18_RS16425	COG1902	pentaerythritol trinitrate reductase activity
FPL18_RS16440	COG3268	Saccharopine dehydrogenase
FPL18_RS16445	COG0604	alcohol dehydrogenase
FPL18_RS16445	COG3321	synthase
FPL18_RS16475	COG0745	RESPONSE REGULATOR receiver
FPL18_RS16480	COG0642	Histidine kinase
FPL18_RS16495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPL18_RS16520	COG1595	DNA-templated transcription, initiation
FPL18_RS16530	COG3220	belongs to the UPF0276 family
FPL18_RS16545	COG0745	RESPONSE REGULATOR receiver
FPL18_RS16550	COG2205	protein histidine kinase activity
FPL18_RS16575	COG0789	Transcriptional regulator
FPL18_RS16585	COG0633	Ferredoxin
FPL18_RS16595	COG1944	ATP diphosphatase activity
FPL18_RS16605	COG0697	spore germination
FPL18_RS16675	COG2207	Transcriptional regulator
FPL18_RS16680	COG1802	Transcriptional regulator
FPL18_RS16700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FPL18_RS16710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPL18_RS16835	COG3561	AntA/AntB antirepressor
FPL18_RS16920	COG3567	Phage-associated protein, HI1409 family
FPL18_RS16925	COG1783	phage Terminase large subunit
FPL18_RS17010	COG0464	growth
FPL18_RS17095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FPL18_RS17145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FPL18_RS17150	COG0148	phosphopyruvate hydratase activity
FPL18_RS17185	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPL18_RS17185	COG1902	pentaerythritol trinitrate reductase activity
FPL18_RS17195	COG2267	carboxylic ester hydrolase activity
FPL18_RS17200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPL18_RS17205	COG0488	(ABC) transporter
FPL18_RS17215	COG0542	response to heat
FPL18_RS17220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FPL18_RS17225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FPL18_RS17260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FPL18_RS17265	COG0569	domain protein
FPL18_RS17270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FPL18_RS17295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPL18_RS17320	COG1294	oxidase, subunit
FPL18_RS17325	COG4890	Cyd operon protein YbgT
FPL18_RS17375	COG0552	protein localization to endoplasmic reticulum
FPL18_RS17400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FPL18_RS17400	COG0517	IMP dehydrogenase activity
FPL18_RS17405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FPL18_RS17410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPL18_RS17420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPL18_RS17425	COG0583	DNA-binding transcription factor activity
FPL18_RS17430	COG0024	Methionine aminopeptidase
FPL18_RS17435	COG1114	Component of the transport system for branched-chain amino acids
FPL18_RS17470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FPL18_RS17475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FPL18_RS17490	COG2814	Major facilitator Superfamily
FPL18_RS17495	COG1309	transcriptional regulator
FPL18_RS17500	COG2431	L-lysine efflux transmembrane transporter activity
FPL18_RS17530	COG0776	regulation of translation
FPL18_RS17550	COG0590	tRNA wobble adenosine to inosine editing
FPL18_RS17595	COG0084	hydrolase, TatD family'
FPL18_RS17630	COG1663	tetraacyldisaccharide 4'-kinase activity
FPL18_RS17635	COG1132	(ABC) transporter
FPL18_RS17645	COG0811	peptide transport
FPL18_RS17650	COG1475	DNA binding
FPL18_RS17655	COG1192	Involved in chromosome partitioning
FPL18_RS17665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FPL18_RS17680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPL18_RS17690	COG0513	Belongs to the DEAD box helicase family
FPL18_RS17710	COG2363	Small membrane protein
FPL18_RS17755	COG4650	regulator
FPL18_RS17760	COG1234	tRNA 3'-trailer cleavage
FPL18_RS17765	COG1690	Belongs to the RtcB family
FPL18_RS17780	COG0430	RNA-3'-phosphate cyclase activity
FPL18_RS17785	COG2195	Cleaves the N-terminal amino acid of tripeptides
FPL18_RS17795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FPL18_RS17815	COG1960	acyl-CoA dehydrogenase activity
FPL18_RS17840	COG3139	Protein of unknown function (DUF1315)
FPL18_RS17845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FPL18_RS17850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FPL18_RS17860	COG0494	nUDIX hydrolase
FPL18_RS17870	COG0642	Histidine kinase
FPL18_RS17875	COG0745	RESPONSE REGULATOR receiver
FPL18_RS17885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPL18_RS17890	COG1720	tRNA m6t6A37 methyltransferase activity
FPL18_RS17915	COG0583	DNA-binding transcription factor activity
FPL18_RS17920	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FPL18_RS17930	COG2814	Major facilitator Superfamily
FPL18_RS17935	COG3647	Membrane
FPL18_RS17940	COG4607	ABC-type enterochelin transport system periplasmic component
FPL18_RS17945	COG4604	ABC transporter, ATP-binding protein
FPL18_RS17950	COG4605	iron ion homeostasis
FPL18_RS17955	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FPL18_RS17960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPL18_RS17965	COG0471	metal ion transport
FPL18_RS17980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FPL18_RS18010	COG0729	surface antigen
FPL18_RS18015	COG0477	Major facilitator Superfamily
FPL18_RS18040	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FPL18_RS18065	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FPL18_RS18075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FPL18_RS18105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS18120	COG4682	membrane
FPL18_RS18135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPL18_RS18175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FPL18_RS18180	COG0864	Transcriptional regulator
FPL18_RS18185	COG0439	Biotin carboxylase
FPL18_RS18230	COG1131	(ABC) transporter
FPL18_RS18235	COG0842	Transport permease protein
FPL18_RS18250	COG0772	Belongs to the SEDS family
FPL18_RS18255	COG2951	lytic endotransglycosylase activity
FPL18_RS18280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPL18_RS18285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FPL18_RS18300	COG1643	Atp-dependent helicase
FPL18_RS18305	COG0450	alkyl hydroperoxide reductase
FPL18_RS18315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL18_RS18355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FPL18_RS18395	COG3501	Rhs element vgr protein
FPL18_RS18455	COG1765	OsmC-like protein
FPL18_RS18465	COG0501	Belongs to the peptidase M48B family
FPL18_RS18470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FPL18_RS18475	COG2072	flavoprotein involved in K transport
FPL18_RS18495	COG1309	transcriptional regulator
FPL18_RS18510	COG3585	molybdate ion transport
FPL18_RS18515	COG3829	transcription factor binding
FPL18_RS18525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS18530	COG1116	anion transmembrane transporter activity
FPL18_RS18540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS18545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS18565	COG0667	Aldo Keto reductase
FPL18_RS18575	COG5002	protein histidine kinase activity
FPL18_RS18585	COG0745	RESPONSE REGULATOR receiver
FPL18_RS18590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPL18_RS18595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPL18_RS18600	COG1538	Outer membrane efflux protein
FPL18_RS18610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPL18_RS18635	COG2837	iron assimilation
FPL18_RS18640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FPL18_RS18645	COG0243	molybdopterin cofactor binding
FPL18_RS18665	COG1271	oxidase subunit
FPL18_RS18670	COG1294	oxidase, subunit
FPL18_RS18675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FPL18_RS18720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FPL18_RS18725	COG0010	Belongs to the arginase family
FPL18_RS18755	COG2188	Transcriptional regulator
FPL18_RS18765	COG0583	DNA-binding transcription factor activity
FPL18_RS18775	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FPL18_RS18785	COG2885	chlorophyll binding
FPL18_RS18795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FPL18_RS18805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FPL18_RS18825	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FPL18_RS18830	COG4266	Belongs to the allantoicase family
FPL18_RS18835	COG2186	Transcriptional regulator
FPL18_RS18840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPL18_RS18855	COG2233	PERMEase
FPL18_RS18860	COG2351	hydroxyisourate hydrolase activity
FPL18_RS18870	COG4993	Dehydrogenase
FPL18_RS18875	COG3659	wide pore channel activity
FPL18_RS18880	COG3420	alginic acid biosynthetic process
FPL18_RS18885	COG0710	3-dehydroquinate dehydratase activity
FPL18_RS18890	COG3485	protocatechuate 3,4-dioxygenase
FPL18_RS18895	COG3485	protocatechuate 3,4-dioxygenase
FPL18_RS18900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FPL18_RS18905	COG2271	Major facilitator Superfamily
FPL18_RS18910	COG0596	Alpha beta hydrolase
FPL18_RS18915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FPL18_RS18920	COG0183	Belongs to the thiolase family
FPL18_RS18925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FPL18_RS18930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FPL18_RS18935	COG1414	Transcriptional regulator
FPL18_RS18940	COG2985	domain, Protein
FPL18_RS18955	COG1012	belongs to the aldehyde dehydrogenase family
FPL18_RS18960	COG4638	Rieske (2fe-2S)
FPL18_RS18975	COG0473	3-isopropylmalate dehydrogenase activity
FPL18_RS18980	COG0583	DNA-binding transcription factor activity