locus-tag	class	description
DS737_RS00010	COG0592	DNA-directed DNA polymerase activity
DS737_RS00020	COG0187	DNA topoisomerase II activity
DS737_RS00025	COG0586	Pfam SNARE associated Golgi protein
DS737_RS00030	COG0488	(ABC) transporter
DS737_RS00055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DS737_RS00060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DS737_RS00100	COG0471	metal ion transport
DS737_RS00100	COG3273	potassium ion transport
DS737_RS00110	COG1012	belongs to the aldehyde dehydrogenase family
DS737_RS00115	COG3738	Protein conserved in bacteria
DS737_RS00125	COG0733	neurotransmitter:sodium symporter activity
DS737_RS00165	COG2233	PERMEase
DS737_RS00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS737_RS00195	COG0484	heat shock protein binding
DS737_RS00210	COG2814	Major facilitator Superfamily
DS737_RS00215	COG0656	L-ascorbic acid biosynthetic process
DS737_RS00220	COG0583	DNA-binding transcription factor activity
DS737_RS00235	COG1064	alcohol dehydrogenase
DS737_RS00240	COG2818	Glycosylase
DS737_RS00255	COG1194	a g-specific adenine glycosylase
DS737_RS00265	COG5487	UPF0391 membrane protein
DS737_RS00270	COG2983	Belongs to the UPF0260 family
DS737_RS00275	COG2133	pyrroloquinoline quinone binding
DS737_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DS737_RS00295	COG1228	amidohydrolase
DS737_RS00300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DS737_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DS737_RS00315	COG1335	isochorismatase
DS737_RS00320	COG1522	sequence-specific DNA binding
DS737_RS00330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DS737_RS00340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DS737_RS00345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DS737_RS00350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DS737_RS00370	COG3830	Belongs to the UPF0237 family
DS737_RS00370	COG0560	Phosphoserine phosphatase
DS737_RS00415	COG1278	Cold shock
DS737_RS00420	COG0583	DNA-binding transcription factor activity
DS737_RS00450	COG0534	Mate efflux family protein
DS737_RS00455	COG0436	Aminotransferase
DS737_RS00465	COG2733	membrane
DS737_RS00480	COG2918	glutathione biosynthetic process
DS737_RS00495	COG3150	esterase
DS737_RS00535	COG1247	-acetyltransferase
DS737_RS00585	COG1393	Belongs to the ArsC family
DS737_RS00590	COG0708	Exodeoxyribonuclease III
DS737_RS00600	COG1181	Belongs to the D-alanine--D-alanine ligase family
DS737_RS00615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DS737_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
DS737_RS00635	COG0300	oxidoreductase activity
DS737_RS00655	COG0386	Belongs to the glutathione peroxidase family
DS737_RS00660	COG0189	ligase activity
DS737_RS00680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DS737_RS00730	COG2119	membrane
DS737_RS00735	COG4774	siderophore transport
DS737_RS00740	COG0426	domain, Protein
DS737_RS00740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DS737_RS00765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DS737_RS00785	COG1902	pentaerythritol trinitrate reductase activity
DS737_RS00790	COG1519	Transferase
DS737_RS00800	COG0668	transmembrane transport
DS737_RS00805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DS737_RS00845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DS737_RS00860	COG0352	thiamine-phosphate diphosphorylase activity
DS737_RS00860	COG0351	phosphomethylpyrimidine kinase
DS737_RS00860	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DS737_RS00870	COG2814	Major facilitator Superfamily
DS737_RS00895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DS737_RS00900	COG1012	belongs to the aldehyde dehydrogenase family
DS737_RS00910	COG1335	isochorismatase
DS737_RS00920	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DS737_RS00955	COG3158	transport of potassium into the cell
DS737_RS00970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DS737_RS00990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS737_RS01010	COG0659	secondary active sulfate transmembrane transporter activity
DS737_RS01025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DS737_RS01060	COG0427	acetyl-CoA hydrolase
DS737_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
DS737_RS01100	COG0583	DNA-binding transcription factor activity
DS737_RS01110	COG0789	Transcriptional regulator
DS737_RS01115	COG3320	Male sterility
DS737_RS01115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS737_RS01120	COG4221	oxidoreductase activity
DS737_RS01125	COG2873	o-acetylhomoserine
DS737_RS01130	COG0488	(ABC) transporter
DS737_RS01200	COG0833	amino acid
DS737_RS01225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DS737_RS01245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DS737_RS01250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DS737_RS01255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DS737_RS01260	COG2226	methyltransferase
DS737_RS01310	COG0067	glutamate synthase
DS737_RS01310	COG0070	glutamate synthase
DS737_RS01310	COG0069	glutamate synthase activity
DS737_RS01315	COG0493	'glutamate synthase
DS737_RS01325	COG1704	LemA family
DS737_RS01330	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DS737_RS01345	COG3307	-O-antigen
DS737_RS01360	COG3307	-O-antigen
DS737_RS01380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DS737_RS01390	COG0194	GDP metabolic process
DS737_RS01395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DS737_RS01465	COG0228	four-way junction DNA binding
DS737_RS01470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DS737_RS01480	COG0335	large ribosomal subunit rRNA binding
DS737_RS01490	COG5380	lipid catabolic process
DS737_RS01520	COG0739	heme binding
DS737_RS01520	COG1196	nuclear chromosome segregation
DS737_RS01520	COG0741	lytic transglycosylase activity
DS737_RS01525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS737_RS01530	COG0277	FAD linked oxidase domain protein
DS737_RS01545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DS737_RS01550	COG2249	NAD(P)H dehydrogenase (quinone) activity
DS737_RS01565	COG1289	transmembrane transporter activity
DS737_RS01570	COG0628	permease
DS737_RS01575	COG1192	Involved in chromosome partitioning
DS737_RS01585	COG2226	methyltransferase
DS737_RS01620	COG1404	Belongs to the peptidase S8 family
DS737_RS01630	COG2072	flavoprotein involved in K transport
DS737_RS01680	COG0471	metal ion transport
DS737_RS01690	COG1983	PspC domain protein
DS737_RS01700	COG1960	acyl-CoA dehydrogenase activity
DS737_RS01725	COG0408	coproporphyrinogen oxidase activity
DS737_RS01745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DS737_RS01755	COG1127	ABC transporter
DS737_RS01760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DS737_RS01765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DS737_RS01770	COG2854	intermembrane phospholipid transfer
DS737_RS01785	COG0598	Magnesium transport protein CorA
DS737_RS01800	COG1040	competence protein
DS737_RS01805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DS737_RS01820	COG2937	Belongs to the GPAT DAPAT family
DS737_RS01825	COG1946	Acyl-CoA thioesterase
DS737_RS01835	COG1301	dicarboxylic acid transport
DS737_RS01855	COG1959	2 iron, 2 sulfur cluster binding
DS737_RS01865	COG0433	COG0433 Predicted ATPase
DS737_RS01885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DS737_RS01905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DS737_RS01955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DS737_RS02035	COG1960	acyl-CoA dehydrogenase activity
DS737_RS02040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DS737_RS02065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DS737_RS02085	COG0339	signal peptide processing
DS737_RS02095	COG0557	exoribonuclease II activity
DS737_RS02195	COG2207	Transcriptional regulator
DS737_RS02205	COG1295	ribonuclease BN
DS737_RS02235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS737_RS02260	COG2813	Specifically methylates the guanine in position
DS737_RS02260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DS737_RS02270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DS737_RS02280	COG3128	pkhd-type hydroxylase
DS737_RS02285	COG4774	siderophore transport
DS737_RS02290	COG4771	TonB-dependent receptor
DS737_RS02300	COG0740	serine-type endopeptidase activity
DS737_RS02320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DS737_RS02320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DS737_RS02325	COG2207	Transcriptional regulator
DS737_RS02325	COG1917	Cupin 2, conserved barrel domain protein
DS737_RS02340	COG0280	phosphate acetyltransferase
DS737_RS02340	COG0857	belongs to the CobB CobQ family
DS737_RS02345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DS737_RS02355	COG2267	carboxylic ester hydrolase activity
DS737_RS02370	COG0793	Belongs to the peptidase S41A family
DS737_RS02390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DS737_RS02400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DS737_RS02405	COG1408	metallophosphoesterase
DS737_RS02415	COG2199	diguanylate cyclase activity
DS737_RS02455	COG1960	acyl-CoA dehydrogenase activity
DS737_RS02475	COG1309	transcriptional regulator
DS737_RS02490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DS737_RS02495	COG1960	acyl-CoA dehydrogenase activity
DS737_RS02550	COG2969	positive regulation of protein catabolic process
DS737_RS02555	COG0625	glutathione transferase activity
DS737_RS02560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DS737_RS02565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DS737_RS02575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DS737_RS02580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DS737_RS02585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DS737_RS02600	COG2975	iron-sulfur cluster assembly
DS737_RS02620	COG1426	Protein conserved in bacteria
DS737_RS02655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS737_RS02665	COG1862	Preprotein translocase
DS737_RS02700	COG5002	protein histidine kinase activity
DS737_RS02705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DS737_RS02715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DS737_RS02725	COG0438	transferase activity, transferring glycosyl groups
DS737_RS02765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DS737_RS02805	COG1960	acyl-CoA dehydrogenase activity
DS737_RS02810	COG1960	acyl-CoA dehydrogenase activity
DS737_RS02820	COG2205	protein histidine kinase activity
DS737_RS02825	COG0745	RESPONSE REGULATOR receiver
DS737_RS02840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DS737_RS02860	COG2096	Adenosyltransferase
DS737_RS02865	COG4206	TonB-dependent receptor
DS737_RS02915	COG0285	dihydrofolate synthase activity
DS737_RS02930	COG0450	alkyl hydroperoxide reductase
DS737_RS02950	COG0477	Major facilitator Superfamily
DS737_RS02955	COG1272	protein, Hemolysin III
DS737_RS02990	COG0183	Belongs to the thiolase family
DS737_RS03000	COG2207	Transcriptional regulator
DS737_RS03005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DS737_RS03040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS737_RS03055	COG0183	Belongs to the thiolase family
DS737_RS03065	COG2885	chlorophyll binding
DS737_RS03065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DS737_RS03075	COG1690	Belongs to the RtcB family
DS737_RS03080	COG0833	amino acid
DS737_RS03090	COG2233	PERMEase
DS737_RS03095	COG1217	gtp-binding protein TYPA
DS737_RS03100	COG1970	mechanosensitive ion channel activity
DS737_RS03135	COG4772	TonB-dependent receptor
DS737_RS03155	COG0354	folic acid binding
DS737_RS03165	COG2824	Alkylphosphonate utilization operon protein PhnA
DS737_RS03170	COG3422	double-strand break repair
DS737_RS03200	COG0840	transmembrane signaling receptor activity
DS737_RS03205	COG2198	Histidine kinase
DS737_RS03205	COG2198	Histidine kinase
DS737_RS03205	COG0643	Histidine kinase
DS737_RS03205	COG0643	Histidine kinase
DS737_RS03220	COG5510	response to toxic substance
DS737_RS03230	COG2832	Protein of unknown function (DUF454)
DS737_RS03235	COG1376	ErfK ybiS ycfS ynhG family protein
DS737_RS03280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS737_RS03290	COG2985	domain, Protein
DS737_RS03300	COG1289	transmembrane transporter activity
DS737_RS03305	COG2814	Major facilitator Superfamily
DS737_RS03320	COG0786	glutamate:sodium symporter activity
DS737_RS03325	COG1115	amino acid carrier protein
DS737_RS03330	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS737_RS03335	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DS737_RS03370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DS737_RS03380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DS737_RS03385	COG1077	Cell shape determining protein MreB Mrl
DS737_RS03390	COG1792	Involved in formation and maintenance of cell shape
DS737_RS03400	COG0424	maF-like protein
DS737_RS03405	COG1530	ribonuclease E activity
DS737_RS03415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS737_RS03425	COG0560	Phosphoserine phosphatase
DS737_RS03440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DS737_RS03445	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DS737_RS03450	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DS737_RS03455	COG2205	protein histidine kinase activity
DS737_RS03460	COG0745	RESPONSE REGULATOR receiver
DS737_RS03470	COG0671	phosphoesterase, PA-phosphatase related
DS737_RS03480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DS737_RS03495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DS737_RS03520	COG1113	amino acid transport
DS737_RS03525	COG2828	Protein conserved in bacteria
DS737_RS03530	COG0142	geranyltranstransferase activity
DS737_RS03545	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS737_RS03565	COG2194	sulfuric ester hydrolase activity
DS737_RS03570	COG0745	RESPONSE REGULATOR receiver
DS737_RS03575	COG0642	Histidine kinase
DS737_RS03585	COG1126	abc transporter atp-binding protein
DS737_RS03590	COG0765	amino acid transport
DS737_RS03595	COG0765	amino acid transport
DS737_RS03605	COG0004	ammonium transporteR
DS737_RS03635	COG0525	valine-tRNA ligase activity
DS737_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
DS737_RS03665	COG0393	Putative heavy-metal-binding
DS737_RS03670	COG1538	Outer membrane efflux protein
DS737_RS03680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS737_RS03685	COG0671	phosphoesterase, PA-phosphatase related
DS737_RS03715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DS737_RS03730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DS737_RS03730	COG1648	precorrin-2 dehydrogenase activity
DS737_RS03735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DS737_RS03745	COG1733	regulation of RNA biosynthetic process
DS737_RS03755	COG0531	amino acid
DS737_RS03770	COG0321	lipoyl(octanoyl) transferase activity
DS737_RS03800	COG1280	lysine exporter protein (LysE YggA)
DS737_RS03810	COG0500	methyltransferase
DS737_RS03815	COG0586	Pfam SNARE associated Golgi protein
DS737_RS03820	COG1054	Belongs to the UPF0176 family
DS737_RS03835	COG2009	succinate dehydrogenase
DS737_RS03840	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DS737_RS03845	COG1053	succinate dehydrogenase
DS737_RS03850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DS737_RS03870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS737_RS03885	COG2268	Band 7 protein
DS737_RS03890	COG1585	Membrane protein implicated in regulation of membrane protease activity
DS737_RS03900	COG2354	Protein conserved in bacteria
DS737_RS03905	COG2321	neutral zinc metallopeptidase
DS737_RS03970	COG0110	maltose O-acetyltransferase activity
DS737_RS03990	COG0505	Belongs to the CarA family
DS737_RS04015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DS737_RS04030	COG2304	oxidoreductase activity
DS737_RS04055	COG0584	glycerophosphoryl diester phosphodiesterase
DS737_RS04060	COG2194	sulfuric ester hydrolase activity
DS737_RS04065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS737_RS04070	COG2239	Acts as a magnesium transporter
DS737_RS04080	COG0501	Belongs to the peptidase M48B family
DS737_RS04085	COG1196	nuclear chromosome segregation
DS737_RS04085	COG0739	heme binding
DS737_RS04085	COG0741	lytic transglycosylase activity
DS737_RS04100	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DS737_RS04105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS737_RS04125	COG1196	nuclear chromosome segregation
DS737_RS04130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS737_RS04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS737_RS04180	COG0653	protein targeting
DS737_RS04215	COG3311	Transcriptional regulator
DS737_RS04285	COG2217	Heavy metal translocating P-type atpase
DS737_RS04290	COG2205	protein histidine kinase activity
DS737_RS04305	COG2132	Multicopper oxidase
DS737_RS04350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS737_RS04365	COG0640	Transcriptional regulator
DS737_RS04375	COG0798	PFAM Bile acid sodium symporter
DS737_RS04380	COG0431	NADPH-dependent FMN reductase
DS737_RS04385	COG0492	ferredoxin-NADP+ reductase activity
DS737_RS04405	COG0582	viral genome integration into host DNA
DS737_RS04415	COG1301	dicarboxylic acid transport
DS737_RS04420	COG0583	DNA-binding transcription factor activity
DS737_RS04520	COG0725	ABC transporter, periplasmic molybdate-binding protein
DS737_RS04525	COG4149	molybdate abc transporter
DS737_RS04540	COG4521	taurine ABC transporter
DS737_RS04545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DS737_RS04550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS737_RS04555	COG2175	clavaminate synthase activity
DS737_RS04580	COG0589	response to stress
DS737_RS04595	COG0242	peptide deformylase activity
DS737_RS04600	COG2066	Belongs to the glutaminase family
DS737_RS04610	COG2223	nitrite transmembrane transporter activity
DS737_RS04615	COG2852	Protein conserved in bacteria
DS737_RS04635	COG0306	phosphate transporter
DS737_RS04650	COG1115	amino acid carrier protein
DS737_RS04660	COG0019	diaminopimelate decarboxylase activity
DS737_RS04665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DS737_RS04675	COG1280	lysine exporter protein (LysE YggA)
DS737_RS04680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DS737_RS04720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS737_RS04740	COG1671	Belongs to the UPF0178 family
DS737_RS04755	COG4591	ABC-type transport system involved in lipoprotein release permease component
DS737_RS04760	COG1136	(ABC) transporter
DS737_RS04765	COG0658	competence protein
DS737_RS04765	COG2333	competence protein COMEC
DS737_RS04775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DS737_RS04775	COG0616	signal peptide processing
DS737_RS04785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DS737_RS04795	COG0628	permease
DS737_RS04835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DS737_RS04855	COG0823	Involved in the tonB-independent uptake of proteins
DS737_RS04875	COG0824	Thioesterase
DS737_RS04885	COG2255	four-way junction helicase activity
DS737_RS04905	COG0047	phosphoribosylformylglycinamidine synthase activity
DS737_RS04905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DS737_RS04920	COG3323	Protein of unknown function (DUF1653)
DS737_RS04920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DS737_RS04925	COG0778	Nitroreductase
DS737_RS04930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DS737_RS04930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DS737_RS04930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DS737_RS04935	COG1105	Belongs to the carbohydrate kinase PfkB family
DS737_RS04940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS737_RS04940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DS737_RS04945	COG1024	Enoyl-CoA hydratase
DS737_RS04950	COG1051	belongs to the nudix hydrolase family
DS737_RS04950	COG1056	cytidyltransferase-related domain
DS737_RS04955	COG0583	DNA-binding transcription factor activity
DS737_RS04960	COG1942	4-Oxalocrotonate Tautomerase
DS737_RS04980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DS737_RS04995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DS737_RS05000	COG0602	queuosine metabolic process
DS737_RS05015	COG0583	DNA-binding transcription factor activity
DS737_RS05020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DS737_RS05025	COG4208	sulfate ABC transporter
DS737_RS05030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DS737_RS05040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DS737_RS05045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS737_RS05050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DS737_RS05065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS737_RS05075	COG0481	GTPase activity
DS737_RS05090	COG0571	ribonuclease III activity
DS737_RS05095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DS737_RS05110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DS737_RS05135	COG0436	Aminotransferase
DS737_RS05160	COG0556	nucleotide-excision repair
DS737_RS05205	COG1840	ABC-type Fe3 transport system, periplasmic component
DS737_RS05210	COG3842	ATPase activity
DS737_RS05230	COG0583	DNA-binding transcription factor activity
DS737_RS05235	COG0596	Alpha beta hydrolase
DS737_RS05240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS737_RS05245	COG1773	rubredoxin
DS737_RS05255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DS737_RS05265	COG0175	sulfate reduction
DS737_RS05280	COG0222	ribosome binding
DS737_RS05285	COG1253	flavin adenine dinucleotide binding
DS737_RS05300	COG3015	lipoprotein NlpE involved in copper resistance
DS737_RS05315	COG0517	IMP dehydrogenase activity
DS737_RS05315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DS737_RS05320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DS737_RS05330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DS737_RS05335	COG1137	ATPase activity
DS737_RS05370	COG4122	O-methyltransferase activity
DS737_RS05380	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DS737_RS05490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DS737_RS05540	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DS737_RS05545	COG3421	Type III restriction
DS737_RS05555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DS737_RS05560	COG3002	Belongs to the UPF0753 family
DS737_RS05605	COG1785	Belongs to the alkaline phosphatase family
DS737_RS05610	COG1785	Belongs to the alkaline phosphatase family
DS737_RS05655	COG0582	viral genome integration into host DNA
DS737_RS05670	COG0583	DNA-binding transcription factor activity
DS737_RS05700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DS737_RS05715	COG0583	DNA-binding transcription factor activity
DS737_RS05750	COG4783	chaperone-mediated protein folding
DS737_RS05765	COG1610	YqeY-like protein
DS737_RS05845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS737_RS05850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS737_RS05855	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS737_RS05860	COG4605	iron ion homeostasis
DS737_RS05865	COG4604	ABC transporter, ATP-binding protein
DS737_RS05870	COG4607	ABC-type enterochelin transport system periplasmic component
DS737_RS05875	COG4774	siderophore transport
DS737_RS05885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS737_RS05885	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DS737_RS05890	COG1021	2,3-dihydroxybenzoate-AMP ligase
DS737_RS05895	COG1535	isochorismatase
DS737_RS05895	COG3433	isochorismatase activity
DS737_RS05905	COG1132	(ABC) transporter
DS737_RS05910	COG1132	(ABC) transporter
DS737_RS05915	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DS737_RS05925	COG1169	isochorismate synthase
DS737_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
DS737_RS05935	COG1414	Transcriptional regulator
DS737_RS05955	COG1028	Short-chain dehydrogenase reductase Sdr
DS737_RS05965	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS737_RS05970	COG2271	Major facilitator Superfamily
DS737_RS05985	COG1028	Short-chain dehydrogenase reductase Sdr
DS737_RS06000	COG0028	Belongs to the TPP enzyme family
DS737_RS06020	COG0482	sulfurtransferase activity
DS737_RS06035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DS737_RS06040	COG1686	Belongs to the peptidase S11 family
DS737_RS06060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DS737_RS06070	COG0583	DNA-binding transcription factor activity
DS737_RS06075	COG1067	ATP-dependent peptidase activity
DS737_RS06095	COG0254	rRNA binding
DS737_RS06115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DS737_RS06120	COG1966	Carbon starvation protein
DS737_RS06125	COG2879	small protein
DS737_RS06130	COG0714	Associated with various cellular activities
DS737_RS06215	COG1401	restriction endodeoxyribonuclease activity
DS737_RS06250	COG1802	Transcriptional regulator
DS737_RS06250	COG4626	Terminase
DS737_RS06255	COG4695	Portal protein
DS737_RS06425	COG1741	Belongs to the pirin family
DS737_RS06440	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS737_RS06440	COG1902	pentaerythritol trinitrate reductase activity
DS737_RS06450	COG1629	transport
DS737_RS06480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DS737_RS06485	COG4451	ribulose bisphosphate carboxylase, small
DS737_RS06485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DS737_RS06490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DS737_RS06495	COG1469	GTP cyclohydrolase I activity
DS737_RS06510	COG0523	cobalamin synthesis protein
DS737_RS06515	COG1414	Transcriptional regulator
DS737_RS06520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DS737_RS06525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DS737_RS06530	COG0183	Belongs to the thiolase family
DS737_RS06535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DS737_RS06540	COG0596	Alpha beta hydrolase
DS737_RS06545	COG2271	Major facilitator Superfamily
DS737_RS06550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DS737_RS06555	COG3485	protocatechuate 3,4-dioxygenase
DS737_RS06560	COG3485	protocatechuate 3,4-dioxygenase
DS737_RS06565	COG0710	3-dehydroquinate dehydratase activity
DS737_RS06570	COG3420	alginic acid biosynthetic process
DS737_RS06575	COG3659	wide pore channel activity
DS737_RS06580	COG4993	Dehydrogenase
DS737_RS06590	COG2351	hydroxyisourate hydrolase activity
DS737_RS06595	COG2233	PERMEase
DS737_RS06615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS737_RS06625	COG4266	Belongs to the allantoicase family
DS737_RS06630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DS737_RS06645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS737_RS06655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS737_RS06670	COG0583	DNA-binding transcription factor activity
DS737_RS06680	COG2188	Transcriptional regulator
DS737_RS06700	COG0010	Belongs to the arginase family
DS737_RS06705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS737_RS06710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS737_RS06720	COG0243	molybdopterin cofactor binding
DS737_RS06725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DS737_RS06730	COG2837	iron assimilation
DS737_RS06740	COG1538	Outer membrane efflux protein
DS737_RS06745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS737_RS06750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS737_RS06755	COG0745	RESPONSE REGULATOR receiver
DS737_RS06760	COG5002	protein histidine kinase activity
DS737_RS06765	COG3040	lipid binding
DS737_RS06785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DS737_RS06795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DS737_RS06800	COG0642	Histidine kinase
DS737_RS06820	COG1309	transcriptional regulator
DS737_RS06840	COG2072	flavoprotein involved in K transport
DS737_RS06845	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DS737_RS06850	COG1560	Kdo2-lipid A biosynthetic process
DS737_RS06855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DS737_RS06860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DS737_RS06865	COG4770	biotin carboxylase activity
DS737_RS06870	COG0501	Belongs to the peptidase M48B family
DS737_RS06880	COG1765	OsmC-like protein
DS737_RS06960	COG0308	aminopeptidase N
DS737_RS06965	COG1760	l-serine dehydratase
DS737_RS06975	COG1714	RDD family
DS737_RS06985	COG0475	glutathione-regulated potassium exporter activity
DS737_RS06985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DS737_RS06990	COG3135	benzoate transporter
DS737_RS07000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DS737_RS07015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DS737_RS07045	COG0316	Belongs to the HesB IscA family
DS737_RS07050	COG0822	iron-sulfur transferase activity
DS737_RS07075	COG0776	regulation of translation
DS737_RS07080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS737_RS07095	COG2137	regulation of response to DNA damage stimulus
DS737_RS07105	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DS737_RS07110	COG1011	Hydrolase
DS737_RS07115	COG1218	3'(2'),5'-bisphosphate nucleotidase
DS737_RS07135	COG0268	Binds directly to 16S ribosomal RNA
DS737_RS07140	COG0702	epimerase
DS737_RS07145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DS737_RS07165	COG0183	Belongs to the thiolase family
DS737_RS07180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS737_RS07210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DS737_RS07215	COG0583	DNA-binding transcription factor activity
DS737_RS07220	COG0424	maF-like protein
DS737_RS07275	COG1286	toxin biosynthetic process
DS737_RS07320	COG3634	alkyl hydroperoxide reductase activity
DS737_RS07355	COG0436	Aminotransferase
DS737_RS07360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DS737_RS07365	COG0386	Belongs to the glutathione peroxidase family
DS737_RS07375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS737_RS07380	COG1522	sequence-specific DNA binding
DS737_RS07390	COG0436	Aminotransferase
DS737_RS07415	COG1253	flavin adenine dinucleotide binding
DS737_RS07420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DS737_RS07430	COG0012	GTP binding
DS737_RS07435	COG2011	ABC-type metal ion transport system permease component
DS737_RS07440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DS737_RS07445	COG1464	Belongs to the NlpA lipoprotein family
DS737_RS07475	COG2195	Cleaves the N-terminal amino acid of tripeptides
DS737_RS07485	COG3550	peptidyl-serine autophosphorylation
DS737_RS07530	COG2363	Small membrane protein
DS737_RS07550	COG0513	Belongs to the DEAD box helicase family
DS737_RS07560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS737_RS07575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DS737_RS07585	COG1192	Involved in chromosome partitioning
DS737_RS07590	COG1475	DNA binding
DS737_RS07595	COG0811	peptide transport
DS737_RS07605	COG1132	(ABC) transporter
DS737_RS07610	COG1663	tetraacyldisaccharide 4'-kinase activity
DS737_RS07635	COG0084	hydrolase, TatD family'
DS737_RS07700	COG0776	regulation of translation
DS737_RS07715	COG2431	L-lysine efflux transmembrane transporter activity
DS737_RS07730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DS737_RS07735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DS737_RS07775	COG0024	Methionine aminopeptidase
DS737_RS07780	COG0583	DNA-binding transcription factor activity
DS737_RS07790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DS737_RS07795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DS737_RS07800	COG0517	IMP dehydrogenase activity
DS737_RS07800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DS737_RS07825	COG0552	protein localization to endoplasmic reticulum
DS737_RS07850	COG4890	Cyd operon protein YbgT
DS737_RS07855	COG1294	oxidase, subunit
DS737_RS07880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS737_RS07900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DS737_RS07905	COG0569	domain protein
DS737_RS07910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DS737_RS07915	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DS737_RS07950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DS737_RS07955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DS737_RS07960	COG0542	response to heat
DS737_RS07970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DS737_RS07975	COG2267	carboxylic ester hydrolase activity
DS737_RS07985	COG1902	pentaerythritol trinitrate reductase activity
DS737_RS07985	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS737_RS08020	COG0148	phosphopyruvate hydratase activity
DS737_RS08025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DS737_RS08080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DS737_RS08090	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DS737_RS08105	COG1802	Transcriptional regulator
DS737_RS08115	COG2207	Transcriptional regulator
DS737_RS08120	COG1063	alcohol dehydrogenase
DS737_RS08130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DS737_RS08170	COG1944	ATP diphosphatase activity
DS737_RS08190	COG1522	sequence-specific DNA binding
DS737_RS08205	COG0439	Biotin carboxylase
DS737_RS08210	COG0864	Transcriptional regulator
DS737_RS08215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS737_RS08225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS737_RS08230	COG1595	DNA-templated transcription, initiation
DS737_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
DS737_RS08300	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS737_RS08300	COG1902	pentaerythritol trinitrate reductase activity
DS737_RS08335	COG0583	DNA-binding transcription factor activity
DS737_RS08345	COG4770	biotin carboxylase activity
DS737_RS08350	COG1024	Enoyl-CoA hydratase
DS737_RS08355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DS737_RS08360	COG1960	acyl-CoA dehydrogenase activity
DS737_RS08365	COG1309	transcriptional regulator
DS737_RS08370	COG0318	PFAM AMP-dependent synthetase and ligase
DS737_RS08385	COG2814	Major facilitator Superfamily
DS737_RS08405	COG0583	DNA-binding transcription factor activity
DS737_RS08415	COG4774	siderophore transport
DS737_RS08435	COG1309	transcriptional regulator
DS737_RS08440	COG2814	Major facilitator Superfamily
DS737_RS08465	COG2249	NAD(P)H dehydrogenase (quinone) activity
DS737_RS08475	COG3706	GGDEF domain
DS737_RS08495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DS737_RS08515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DS737_RS08560	COG0537	adenosine 5'-monophosphoramidase activity
DS737_RS08590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS737_RS08610	COG0730	response to heat
DS737_RS08615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DS737_RS08625	COG4771	TonB-dependent receptor
DS737_RS08645	COG0406	alpha-ribazole phosphatase activity
DS737_RS08650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DS737_RS08665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DS737_RS08680	COG2814	Major facilitator Superfamily
DS737_RS08725	COG1960	acyl-CoA dehydrogenase activity
DS737_RS08730	COG1960	acyl-CoA dehydrogenase activity
DS737_RS08735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS737_RS08740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS737_RS08745	COG2207	Transcriptional regulator
DS737_RS08750	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS737_RS08770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS737_RS08785	COG0575	Belongs to the CDS family
DS737_RS08790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DS737_RS08800	COG0528	UMP kinase activity
DS737_RS08810	COG3852	Histidine kinase
DS737_RS08815	COG2204	response regulator
DS737_RS08820	COG1309	transcriptional regulator
DS737_RS08870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DS737_RS08890	COG0697	spore germination
DS737_RS08895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS737_RS08905	COG0303	'Molybdopterin
DS737_RS08910	COG0315	cyclic pyranopterin monophosphate synthase activity
DS737_RS08910	COG0521	Mo-molybdopterin cofactor biosynthetic process
DS737_RS08925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DS737_RS08930	COG0243	molybdopterin cofactor binding
DS737_RS08945	COG0243	molybdopterin cofactor binding
DS737_RS08950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS737_RS08955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS737_RS08955	COG2146	nitrite reductase [NAD(P)H] activity
DS737_RS08960	COG2223	nitrite transmembrane transporter activity
DS737_RS08970	COG1116	anion transmembrane transporter activity
DS737_RS08970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS737_RS08985	COG0439	Biotin carboxylase
DS737_RS09000	COG2814	Major facilitator Superfamily
DS737_RS09010	COG0069	glutamate synthase activity
DS737_RS09030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DS737_RS09035	COG3038	cytochrome b561
DS737_RS09040	COG1454	alcohol dehydrogenase
DS737_RS09045	COG0824	Thioesterase
DS737_RS09055	COG2850	peptidyl-arginine hydroxylation
DS737_RS09075	COG0640	Transcriptional regulator
DS737_RS09100	COG0668	transmembrane transport
DS737_RS09110	COG1132	(ABC) transporter
DS737_RS09130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS737_RS09140	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DS737_RS09140	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DS737_RS09140	COG0506	proline dehydrogenase activity
DS737_RS09145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DS737_RS09150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DS737_RS09160	COG3698	Phosphodiester glycosidase
DS737_RS09175	COG3153	acetyltransferase
DS737_RS09180	COG2353	YceI-like domain
DS737_RS09200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DS737_RS09205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DS737_RS09220	COG3042	response to heat
DS737_RS09230	COG1278	Cold shock
DS737_RS09235	COG1278	Cold shock
DS737_RS09255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DS737_RS09255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DS737_RS09280	COG3539	Fimbrial protein
DS737_RS09335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DS737_RS09355	COG1960	acyl-CoA dehydrogenase activity
DS737_RS09360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS737_RS09390	COG3139	Protein of unknown function (DUF1315)
DS737_RS09395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DS737_RS09400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DS737_RS09410	COG0494	nUDIX hydrolase
DS737_RS09420	COG0642	Histidine kinase
DS737_RS09435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DS737_RS09440	COG1720	tRNA m6t6A37 methyltransferase activity
DS737_RS09475	COG0583	DNA-binding transcription factor activity
DS737_RS09480	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DS737_RS09490	COG2814	Major facilitator Superfamily
DS737_RS09495	COG4607	ABC-type enterochelin transport system periplasmic component
DS737_RS09500	COG4604	ABC transporter, ATP-binding protein
DS737_RS09505	COG4605	iron ion homeostasis
DS737_RS09510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS737_RS09520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DS737_RS09525	COG0471	metal ion transport
DS737_RS09550	COG0729	surface antigen
DS737_RS09575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DS737_RS09595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DS737_RS09605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DS737_RS09710	COG3659	wide pore channel activity
DS737_RS09720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DS737_RS09730	COG0583	DNA-binding transcription factor activity
DS737_RS09735	COG1131	(ABC) transporter
DS737_RS09740	COG0842	Transport permease protein
DS737_RS09755	COG0772	Belongs to the SEDS family
DS737_RS09760	COG2951	lytic endotransglycosylase activity
DS737_RS09785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DS737_RS09800	COG1643	Atp-dependent helicase
DS737_RS09805	COG0450	alkyl hydroperoxide reductase
DS737_RS09815	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS737_RS09835	COG3634	alkyl hydroperoxide reductase activity
DS737_RS09855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DS737_RS09870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DS737_RS09880	COG0531	amino acid
DS737_RS09885	COG4303	Ethanolamine ammonia lyase large subunit
DS737_RS09890	COG4302	ethanolamine ammonia-lyase activity
DS737_RS09895	COG0519	Catalyzes the synthesis of GMP from XMP
DS737_RS09895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DS737_RS09900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DS737_RS09910	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DS737_RS09920	COG2249	NAD(P)H dehydrogenase (quinone) activity
DS737_RS09930	COG0697	spore germination
DS737_RS09935	COG1923	regulation of RNA biosynthetic process
DS737_RS09945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DS737_RS09950	COG0802	atpase or kinase
DS737_RS09980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS737_RS09985	COG3300	MHYT domain
DS737_RS09985	COG5001	Diguanylate cyclase
DS737_RS10005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DS737_RS10010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DS737_RS10015	COG1845	cytochrome c oxidase, subunit III
DS737_RS10020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DS737_RS10045	COG2249	NAD(P)H dehydrogenase (quinone) activity
DS737_RS10050	COG1733	regulation of RNA biosynthetic process
DS737_RS10055	COG0305	Participates in initiation and elongation during chromosome replication
DS737_RS10060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DS737_RS10075	COG1305	Transglutaminase-like
DS737_RS10085	COG2308	Evidence 4 Homologs of previously reported genes of
DS737_RS10095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DS737_RS10110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DS737_RS10120	COG0527	aspartate kinase activity
DS737_RS10130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DS737_RS10140	COG3038	cytochrome b561
DS737_RS10145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DS737_RS10150	COG2252	PERMEase
DS737_RS10175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS737_RS10185	COG1477	protein flavinylation
DS737_RS10220	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DS737_RS10225	COG0138	bifunctional purine biosynthesis protein purh
DS737_RS10230	COG0151	Belongs to the GarS family
DS737_RS10235	COG1464	Belongs to the NlpA lipoprotein family
DS737_RS10240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DS737_RS10245	COG2011	ABC-type metal ion transport system permease component
DS737_RS10270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DS737_RS10275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DS737_RS10280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DS737_RS10305	COG0052	Belongs to the universal ribosomal protein uS2 family
DS737_RS10310	COG0024	Methionine aminopeptidase
DS737_RS10320	COG2223	nitrite transmembrane transporter activity
DS737_RS10330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS737_RS10335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DS737_RS10340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DS737_RS10345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DS737_RS10385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DS737_RS10390	COG3161	chorismate lyase activity
DS737_RS10395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DS737_RS10430	COG0174	glutamine synthetase
DS737_RS10435	COG0512	Glutamine amidotransferase of anthranilate synthase
DS737_RS10440	COG1823	symporter activity
DS737_RS10445	COG0633	Ferredoxin
DS737_RS10445	COG3217	Mosc domain protein beta barrel domain protein
DS737_RS10470	COG0302	gtp cyclohydrolase
DS737_RS10490	COG3739	integral membrane protein
DS737_RS10505	COG2203	Gaf domain
DS737_RS10505	COG4251	negative regulation of phosphorylation
DS737_RS10505	COG5001	Diguanylate cyclase
DS737_RS10505	COG3706	GGDEF domain
DS737_RS10515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DS737_RS10530	COG4172	Belongs to the ABC transporter superfamily
DS737_RS10535	COG4239	(ABC) transporter, permease
DS737_RS10540	COG4174	ABC transporter (Permease)
DS737_RS10545	COG4166	transmembrane transport
DS737_RS10550	COG0741	lytic transglycosylase activity
DS737_RS10550	COG1388	LysM domain
DS737_RS10550	COG1388	LysM domain
DS737_RS10550	COG0741	lytic transglycosylase activity
DS737_RS10565	COG2816	NAD+ diphosphatase activity
DS737_RS10595	COG0583	DNA-binding transcription factor activity
DS737_RS10600	COG1279	arginine transmembrane transporter activity
DS737_RS10610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS737_RS10615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS737_RS10625	COG0006	proline dipeptidase activity
DS737_RS10670	COG3772	lysozyme
DS737_RS10730	COG2217	Heavy metal translocating P-type atpase
DS737_RS10745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DS737_RS10760	COG3384	dioxygenase
DS737_RS10770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS737_RS10830	COG2878	Part of a membrane complex involved in electron transport
DS737_RS10835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DS737_RS10860	COG0768	penicillin binding
DS737_RS10865	COG0742	ribosomal rna small subunit methyltransferase
DS737_RS10890	COG0616	signal peptide processing
DS737_RS10895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DS737_RS10905	COG0573	inorganic phosphate transmembrane transporter activity
DS737_RS10920	COG0076	glutamate decarboxylase activity
DS737_RS10925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DS737_RS10935	COG1309	transcriptional regulator
DS737_RS10965	COG0783	Belongs to the Dps family
DS737_RS10975	COG0564	pseudouridine synthase activity
DS737_RS10990	COG0352	thiamine-phosphate diphosphorylase activity
DS737_RS11050	COG0612	Peptidase, M16
DS737_RS11055	COG0384	phenazine biosynthesis protein PhzF
DS737_RS11090	COG1686	Belongs to the peptidase S11 family
DS737_RS11095	COG1252	NADH dehydrogenase
DS737_RS11105	COG0415	Belongs to the DNA photolyase family
DS737_RS11120	COG1215	transferase activity, transferring glycosyl groups
DS737_RS11145	COG1271	oxidase subunit
DS737_RS11150	COG1294	oxidase, subunit
DS737_RS11170	COG0705	Rhomboid family
DS737_RS11170	COG0457	Tetratricopeptide repeat
DS737_RS11180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DS737_RS11185	COG4181	ATPase activity
DS737_RS11195	COG0456	acetyltransferase
DS737_RS11235	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DS737_RS11265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DS737_RS11270	COG1597	lipid kinase activity
DS737_RS11275	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DS737_RS11290	COG3210	domain, Protein
DS737_RS11295	COG2831	hemolysin activation secretion protein
DS737_RS11315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DS737_RS11325	COG2388	GCN5-related N-acetyl-transferase
DS737_RS11370	COG4681	YaeQ
DS737_RS11375	COG0523	cobalamin synthesis protein
DS737_RS11385	COG1607	acyl-coa hydrolase
DS737_RS11405	COG2814	Major facilitator Superfamily
DS737_RS11410	COG1024	Enoyl-CoA hydratase
DS737_RS11415	COG1012	belongs to the aldehyde dehydrogenase family
DS737_RS11425	COG1960	acyl-CoA dehydrogenase activity
DS737_RS11445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS737_RS11450	COG1414	Transcriptional regulator
DS737_RS11455	COG0281	malic enzyme
DS737_RS11460	COG0833	amino acid
DS737_RS11475	COG1012	belongs to the aldehyde dehydrogenase family
DS737_RS11485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DS737_RS11490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS737_RS11500	COG1960	acyl-CoA dehydrogenase activity
DS737_RS11505	COG1454	alcohol dehydrogenase
DS737_RS11510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DS737_RS11555	COG0446	pyridine nucleotide-disulphide oxidoreductase
DS737_RS11555	COG1902	pentaerythritol trinitrate reductase activity
DS737_RS11565	COG4689	acetoacetate decarboxylase
DS737_RS11570	COG4221	oxidoreductase activity
DS737_RS11585	COG2814	Major facilitator Superfamily
DS737_RS11590	COG1566	PFAM secretion protein HlyD family protein
DS737_RS11595	COG2050	protein possibly involved in aromatic compounds catabolism
DS737_RS11605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS737_RS11610	COG1090	epimerase
DS737_RS11630	COG0420	3'-5' exonuclease activity
DS737_RS11670	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS737_RS11675	COG2914	Belongs to the UPF0125 (RnfH) family
DS737_RS11690	COG0121	glutamine amidotransferase
DS737_RS11705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DS737_RS11710	COG0756	dUTP diphosphatase activity
DS737_RS11715	COG0210	DNA helicase
DS737_RS11720	COG2885	chlorophyll binding
DS737_RS11725	COG0204	Acyl-transferase
DS737_RS11735	COG0850	regulation of cytokinetic process
DS737_RS11740	COG2894	cell division
DS737_RS11745	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DS737_RS11755	COG1280	lysine exporter protein (LysE YggA)
DS737_RS11760	COG1674	ftsk spoiiie
DS737_RS11760	COG0531	amino acid
DS737_RS11765	COG0492	ferredoxin-NADP+ reductase activity
DS737_RS11770	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DS737_RS11780	COG0456	acetyltransferase
DS737_RS11795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DS737_RS11805	COG0049	tRNA binding
DS737_RS11825	COG1981	membrane
DS737_RS11835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS737_RS11835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DS737_RS11860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DS737_RS11885	COG0564	pseudouridine synthase activity
DS737_RS11895	COG0358	DNA primase activity
DS737_RS11910	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DS737_RS11940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DS737_RS11975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DS737_RS11985	COG0351	phosphomethylpyrimidine kinase
DS737_RS11985	COG0352	thiamine-phosphate diphosphorylase activity
DS737_RS11985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DS737_RS11995	COG1652	LysM domain
DS737_RS12020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DS737_RS12025	COG1399	metal-binding, possibly nucleic acid-binding protein
DS737_RS12030	COG3101	peptidyl-lysine hydroxylation
DS737_RS12035	COG0009	L-threonylcarbamoyladenylate synthase
DS737_RS12055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DS737_RS12060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DS737_RS12080	COG4106	trans-aconitate 2-methyltransferase activity
DS737_RS12095	COG0596	Alpha beta hydrolase
DS737_RS12105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DS737_RS12120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DS737_RS12130	COG1196	nuclear chromosome segregation
DS737_RS12140	COG0730	response to heat
DS737_RS12160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DS737_RS12220	COG2358	TRAP transporter, solute receptor (TAXI family
DS737_RS12235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DS737_RS12240	COG0489	protein tyrosine kinase activity
DS737_RS12260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS737_RS12260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS737_RS12270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DS737_RS12290	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DS737_RS12295	COG2081	HI0933 family
DS737_RS12300	COG0668	transmembrane transport
DS737_RS12315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DS737_RS12320	COG0583	DNA-binding transcription factor activity
DS737_RS12345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DS737_RS12350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DS737_RS12365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DS737_RS12380	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DS737_RS12390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DS737_RS12390	COG0649	NAD binding
DS737_RS12400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DS737_RS12415	COG2205	protein histidine kinase activity
DS737_RS12420	COG0745	RESPONSE REGULATOR receiver
DS737_RS12435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS737_RS12440	COG0431	NADPH-dependent FMN reductase
DS737_RS12445	COG0798	PFAM Bile acid sodium symporter
DS737_RS12455	COG0640	Transcriptional regulator
DS737_RS12555	COG1131	(ABC) transporter
DS737_RS12565	COG1113	amino acid transport
DS737_RS12575	COG0625	glutathione transferase activity
DS737_RS12600	COG2814	Major facilitator Superfamily
DS737_RS12610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS737_RS12615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS737_RS12620	COG1309	transcriptional regulator
DS737_RS12645	COG1063	alcohol dehydrogenase
DS737_RS12680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DS737_RS12685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DS737_RS12690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DS737_RS12695	COG2076	Multidrug Resistance protein
DS737_RS12715	COG2132	Multicopper oxidase
DS737_RS12725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DS737_RS12750	COG1968	undecaprenyl-diphosphatase activity
DS737_RS12755	COG1214	PFAM Peptidase M22, glycoprotease
DS737_RS12765	COG0494	nUDIX hydrolase
DS737_RS12815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DS737_RS12825	COG1595	DNA-templated transcription, initiation
DS737_RS12830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DS737_RS12835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DS737_RS12900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS737_RS12910	COG1764	response to oxidative stress
DS737_RS12935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS737_RS12935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS737_RS12950	COG0037	tRNA processing
DS737_RS12960	COG0248	Ppx GppA phosphatase
DS737_RS12985	COG0072	phenylalanine-tRNA ligase activity
DS737_RS13020	COG1238	metal cluster binding
DS737_RS13035	COG0625	glutathione transferase activity
DS737_RS13055	COG0318	PFAM AMP-dependent synthetase and ligase
DS737_RS13060	COG3028	Belongs to the UPF0307 family
DS737_RS13085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DS737_RS13090	COG0617	tRNA 3'-terminal CCA addition
DS737_RS13095	COG1555	photosystem II stabilization
DS737_RS13100	COG3956	TIGRFAM MazG family protein
DS737_RS13115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DS737_RS13135	COG0784	Response regulator, receiver
DS737_RS13135	COG2205	protein histidine kinase activity
DS737_RS13135	COG5002	protein histidine kinase activity
DS737_RS13140	COG1024	Enoyl-CoA hydratase
DS737_RS13145	COG2084	Dehydrogenase
DS737_RS13150	COG3622	Belongs to the hyi family
DS737_RS13195	COG2814	Major facilitator Superfamily
DS737_RS13200	COG5285	phytanoyl-CoA dioxygenase
DS737_RS13205	COG1917	Cupin 2, conserved barrel domain protein
DS737_RS13215	COG0456	acetyltransferase
DS737_RS13225	COG0431	NADPH-dependent FMN reductase
DS737_RS13230	COG0798	PFAM Bile acid sodium symporter
DS737_RS13240	COG0640	Transcriptional regulator
DS737_RS13255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS737_RS13265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DS737_RS13285	COG0084	hydrolase, TatD family'
DS737_RS13300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DS737_RS13355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DS737_RS13360	COG0440	acetolactate synthase activity
DS737_RS13365	COG0028	Belongs to the TPP enzyme family
DS737_RS13385	COG1466	dna polymerase III delta subunit
DS737_RS13390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS737_RS13395	COG1136	(ABC) transporter
DS737_RS13395	COG0577	efflux transmembrane transporter activity
DS737_RS13400	COG1538	Outer membrane efflux protein
DS737_RS13425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DS737_RS13430	COG1162	GTPase activity
DS737_RS13440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DS737_RS13475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DS737_RS13485	COG3781	membrane
DS737_RS13525	COG1666	GTP binding
DS737_RS13540	COG1956	GAF domain-containing protein
DS737_RS13545	COG1607	acyl-coa hydrolase
DS737_RS13600	COG1183	phosphatidylcholine synthase activity
DS737_RS13605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DS737_RS13635	COG0741	lytic transglycosylase activity
DS737_RS13635	COG1196	nuclear chromosome segregation
DS737_RS13635	COG0739	heme binding
DS737_RS13645	COG1702	phosphate starvation-inducible protein PhoH
DS737_RS13685	COG3878	Protein conserved in bacteria
DS737_RS13730	COG0788	formyltetrahydrofolate deformylase activity
DS737_RS13755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DS737_RS13755	COG4651	solute:proton antiporter activity
DS737_RS13780	COG0210	DNA helicase
DS737_RS13805	COG1733	regulation of RNA biosynthetic process
DS737_RS13815	COG2900	Belongs to the SlyX family
DS737_RS13820	COG0488	(ABC) transporter
DS737_RS13830	COG1560	Kdo2-lipid A biosynthetic process
DS737_RS13880	COG0473	3-isopropylmalate dehydrogenase activity
DS737_RS13915	COG0494	nUDIX hydrolase
DS737_RS13935	COG3011	Protein conserved in bacteria
DS737_RS13950	COG0625	glutathione transferase activity
DS737_RS13960	COG0546	phosphoglycolate phosphatase activity
DS737_RS13965	COG0564	pseudouridine synthase activity
DS737_RS13975	COG1530	ribonuclease E activity
DS737_RS13980	COG0318	PFAM AMP-dependent synthetase and ligase
DS737_RS13995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DS737_RS14005	COG0534	Mate efflux family protein
DS737_RS14010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DS737_RS14045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DS737_RS14060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DS737_RS14060	COG0493	'glutamate synthase
DS737_RS14070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DS737_RS14110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS737_RS14125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DS737_RS14135	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DS737_RS14135	COG0644	oxidoreductase
DS737_RS14140	COG0425	Belongs to the sulfur carrier protein TusA family
DS737_RS14145	COG4535	Mg2 and Co2 transporter CorC
DS737_RS14150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DS737_RS14170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DS737_RS14180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DS737_RS14190	COG0484	heat shock protein binding
DS737_RS14195	COG0789	Transcriptional regulator
DS737_RS14200	COG0598	Magnesium transport protein CorA
DS737_RS14205	COG1185	polyribonucleotide nucleotidyltransferase activity
DS737_RS14210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DS737_RS14215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS737_RS14220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DS737_RS14225	COG1074	ATP-dependent DNA helicase activity
DS737_RS14230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DS737_RS14255	COG2226	methyltransferase
DS737_RS14270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS737_RS14280	COG1116	anion transmembrane transporter activity
DS737_RS14285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS737_RS14295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DS737_RS14310	COG2111	Na H antiporter
DS737_RS14310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DS737_RS14315	COG1006	Multisubunit Na H antiporter MnhC subunit
DS737_RS14320	COG0651	ATP synthesis coupled electron transport
DS737_RS14325	COG1863	multisubunit Na H antiporter MnhE subunit
DS737_RS14330	COG2212	antiporter activity
DS737_RS14335	COG1320	monovalent cation:proton antiporter activity
DS737_RS14355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DS737_RS14365	COG0195	Participates in both transcription termination and antitermination
DS737_RS14415	COG0237	dephospho-CoA kinase activity
DS737_RS14430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DS737_RS14440	COG0497	DNA recombination
DS737_RS14450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DS737_RS14475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DS737_RS14515	COG1132	(ABC) transporter
DS737_RS14525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DS737_RS14540	COG0326	Molecular chaperone. Has ATPase activity
DS737_RS14550	COG2056	Na+-H+ antiporter family
DS737_RS14600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DS737_RS14610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DS737_RS14620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DS737_RS14650	COG0546	phosphoglycolate phosphatase activity
DS737_RS14655	COG1716	ATPase activity
DS737_RS14700	COG0181	hydroxymethylbilane synthase activity
DS737_RS14710	COG3275	phosphorelay sensor kinase activity
DS737_RS14735	COG0494	nUDIX hydrolase
DS737_RS14745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DS737_RS14750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DS737_RS14755	COG0772	Belongs to the SEDS family
DS737_RS14780	COG4974	Belongs to the 'phage' integrase family
DS737_RS14785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DS737_RS14795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DS737_RS14800	COG1686	Belongs to the peptidase S11 family
DS737_RS14805	COG2197	response regulator
DS737_RS14820	COG0793	Belongs to the peptidase S41A family
DS737_RS14825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DS737_RS14830	COG0795	lipopolysaccharide-transporting ATPase activity
DS737_RS14835	COG0795	lipopolysaccharide-transporting ATPase activity
DS737_RS14875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS737_RS14875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS737_RS14880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DS737_RS14885	COG0004	ammonium transporteR
DS737_RS14890	COG0347	Belongs to the P(II) protein family
DS737_RS14935	COG0318	PFAM AMP-dependent synthetase and ligase
DS737_RS14955	COG2860	membrane
DS737_RS14965	COG1253	flavin adenine dinucleotide binding
DS737_RS14985	COG2814	Major facilitator Superfamily
DS737_RS14995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS737_RS15020	COG2814	Major facilitator Superfamily
DS737_RS15030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS737_RS15040	COG1283	sodium-dependent phosphate transmembrane transporter activity
DS737_RS15075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS737_RS15090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS737_RS15100	COG2205	protein histidine kinase activity
DS737_RS15125	COG1652	LysM domain
DS737_RS15130	COG0758	DNA mediated transformation
DS737_RS15145	COG1309	transcriptional regulator
DS737_RS15150	COG2814	Major facilitator Superfamily
DS737_RS15160	COG0386	Belongs to the glutathione peroxidase family
DS737_RS15185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DS737_RS15195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DS737_RS15235	COG1121	(ABC) transporter
DS737_RS15240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DS737_RS15245	COG1280	lysine exporter protein (LysE YggA)
DS737_RS15250	COG2837	iron assimilation
DS737_RS15285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DS737_RS15305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DS737_RS15310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DS737_RS15310	COG0519	Catalyzes the synthesis of GMP from XMP
DS737_RS15315	COG4399	Belongs to the UPF0754 family
DS737_RS15325	COG2259	Doxx family
DS737_RS15330	COG0586	Pfam SNARE associated Golgi protein
DS737_RS15345	COG1192	Involved in chromosome partitioning
DS737_RS15355	COG0271	Belongs to the BolA IbaG family
DS737_RS15370	COG0477	Major facilitator Superfamily
DS737_RS15375	COG1024	Enoyl-CoA hydratase
DS737_RS15380	COG1024	Enoyl-CoA hydratase
DS737_RS15385	COG1960	acyl-CoA dehydrogenase activity
DS737_RS15390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DS737_RS15410	COG1113	amino acid transport
DS737_RS15415	COG0251	oxidation-reduction process
DS737_RS15445	COG0456	acetyltransferase
DS737_RS15450	COG0564	pseudouridine synthase activity
DS737_RS15455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DS737_RS15485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DS737_RS15500	COG1802	Transcriptional regulator
DS737_RS15505	COG1448	Aminotransferase
DS737_RS15515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DS737_RS15520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DS737_RS15535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DS737_RS15545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DS737_RS15555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DS737_RS15560	COG0438	transferase activity, transferring glycosyl groups
DS737_RS15575	COG1216	Glycosyl transferase, family 2
DS737_RS15575	COG0463	Glycosyl transferase, family 2
DS737_RS15595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DS737_RS15600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DS737_RS15635	COG3023	N-Acetylmuramoyl-L-alanine amidase
DS737_RS15685	COG0546	phosphoglycolate phosphatase activity
DS737_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
DS737_RS15700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DS737_RS15700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DS737_RS15705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS737_RS15710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS737_RS15715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS737_RS15720	COG1116	anion transmembrane transporter activity
DS737_RS15725	COG1309	transcriptional regulator
DS737_RS15735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DS737_RS15745	COG0196	riboflavin kinase activity
DS737_RS15750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DS737_RS15760	COG1047	Peptidyl-prolyl cis-trans
DS737_RS15800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DS737_RS15805	COG0657	acetylesterase activity
DS737_RS15825	COG0583	DNA-binding transcription factor activity
DS737_RS15835	COG0443	Heat shock 70 kDa protein
DS737_RS15865	COG2951	lytic endotransglycosylase activity
DS737_RS15870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DS737_RS15890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DS737_RS15915	COG1960	acyl-CoA dehydrogenase activity
DS737_RS15925	COG0861	Integral membrane protein TerC family
DS737_RS15930	COG0402	S-adenosylhomocysteine deaminase activity
DS737_RS15945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DS737_RS15955	COG0706	membrane insertase activity