locus-tag	class	description
FK538_RS00045	COG3328	transposase activity
FK538_RS00080	COG3077	Addiction module antitoxin, RelB DinJ family
FK538_RS00085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK538_RS00090	COG0592	DNA-directed DNA polymerase activity
FK538_RS00100	COG0187	DNA topoisomerase II activity
FK538_RS00125	COG0488	(ABC) transporter
FK538_RS00150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FK538_RS00155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FK538_RS00180	COG0737	Belongs to the 5'-nucleotidase family
FK538_RS00210	COG2814	Major facilitator Superfamily
FK538_RS00220	COG1012	belongs to the aldehyde dehydrogenase family
FK538_RS00225	COG0733	neurotransmitter:sodium symporter activity
FK538_RS00235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FK538_RS00255	COG0129	dihydroxy-acid dehydratase activity
FK538_RS00275	COG2233	PERMEase
FK538_RS00285	COG1309	transcriptional regulator
FK538_RS00290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK538_RS00345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FK538_RS00360	COG0438	transferase activity, transferring glycosyl groups
FK538_RS00365	COG1216	Glycosyl transferase, family 2
FK538_RS00365	COG1442	glycosyl transferase family 8
FK538_RS00375	COG0438	transferase activity, transferring glycosyl groups
FK538_RS00385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FK538_RS00400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FK538_RS00415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK538_RS00420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK538_RS00450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FK538_RS00460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FK538_RS00495	COG0271	Belongs to the BolA IbaG family
FK538_RS00505	COG1192	Involved in chromosome partitioning
FK538_RS00520	COG0586	Pfam SNARE associated Golgi protein
FK538_RS00525	COG2259	Doxx family
FK538_RS00530	COG0519	Catalyzes the synthesis of GMP from XMP
FK538_RS00530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK538_RS00570	COG0281	malic enzyme
FK538_RS00575	COG3501	Rhs element vgr protein
FK538_RS00580	COG3179	chitinase
FK538_RS00600	COG2837	iron assimilation
FK538_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FK538_RS00615	COG1121	(ABC) transporter
FK538_RS00665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FK538_RS00690	COG0386	Belongs to the glutathione peroxidase family
FK538_RS00695	COG0697	spore germination
FK538_RS00710	COG0758	DNA mediated transformation
FK538_RS00760	COG2814	Major facilitator Superfamily
FK538_RS00780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK538_RS00795	COG2814	Major facilitator Superfamily
FK538_RS00815	COG1253	flavin adenine dinucleotide binding
FK538_RS00825	COG2860	membrane
FK538_RS00830	COG0477	Major facilitator Superfamily
FK538_RS00840	COG0318	PFAM AMP-dependent synthetase and ligase
FK538_RS00855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FK538_RS00880	COG0347	Belongs to the P(II) protein family
FK538_RS00885	COG0004	ammonium transporteR
FK538_RS00895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK538_RS00895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK538_RS00910	COG0586	Pfam SNARE associated Golgi protein
FK538_RS00935	COG0795	lipopolysaccharide-transporting ATPase activity
FK538_RS00940	COG0795	lipopolysaccharide-transporting ATPase activity
FK538_RS00945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FK538_RS00950	COG0793	Belongs to the peptidase S41A family
FK538_RS00965	COG2197	response regulator
FK538_RS00975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FK538_RS00990	COG4974	Belongs to the 'phage' integrase family
FK538_RS01015	COG0772	Belongs to the SEDS family
FK538_RS01025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK538_RS01030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FK538_RS01035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FK538_RS01040	COG0494	nUDIX hydrolase
FK538_RS01075	COG3275	phosphorelay sensor kinase activity
FK538_RS01085	COG0181	hydroxymethylbilane synthase activity
FK538_RS01105	COG0824	Thioesterase
FK538_RS01190	COG0081	regulation of translation
FK538_RS01205	COG0085	RNA polymerase activity
FK538_RS01210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FK538_RS01230	COG2056	Na+-H+ antiporter family
FK538_RS01245	COG0326	Molecular chaperone. Has ATPase activity
FK538_RS01275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FK538_RS01285	COG2233	PERMEase
FK538_RS01295	COG1024	Enoyl-CoA hydratase
FK538_RS01295	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK538_RS01325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FK538_RS01330	COG1132	(ABC) transporter
FK538_RS01345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FK538_RS01355	COG0497	DNA recombination
FK538_RS01360	COG3123	guanosine phosphorylase activity
FK538_RS01365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK538_RS01375	COG0237	dephospho-CoA kinase activity
FK538_RS01425	COG0779	Required for maturation of 30S ribosomal subunits
FK538_RS01430	COG0195	Participates in both transcription termination and antitermination
FK538_RS01440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FK538_RS01450	COG2212	antiporter activity
FK538_RS01460	COG0651	ATP synthesis coupled electron transport
FK538_RS01465	COG1006	Multisubunit Na H antiporter MnhC subunit
FK538_RS01470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK538_RS01470	COG2111	Na H antiporter
FK538_RS01485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FK538_RS01495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK538_RS01525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FK538_RS01530	COG1074	ATP-dependent DNA helicase activity
FK538_RS01535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK538_RS01540	COG0675	Transposase, IS605 OrfB family
FK538_RS01545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FK538_RS01560	COG2841	Protein conserved in bacteria
FK538_RS01565	COG0789	Transcriptional regulator
FK538_RS01575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FK538_RS01585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FK538_RS01605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FK538_RS01610	COG4535	Mg2 and Co2 transporter CorC
FK538_RS01615	COG0425	Belongs to the sulfur carrier protein TusA family
FK538_RS01620	COG3501	Rhs element vgr protein
FK538_RS01695	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FK538_RS01695	COG0644	oxidoreductase
FK538_RS01705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FK538_RS01720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK538_RS01730	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FK538_RS01740	COG0493	'glutamate synthase
FK538_RS01740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK538_RS01750	COG2226	methyltransferase
FK538_RS01765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK538_RS01795	COG0751	glycine-tRNA ligase activity
FK538_RS01805	COG0517	IMP dehydrogenase activity
FK538_RS01805	COG0617	tRNA 3'-terminal CCA addition
FK538_RS01805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK538_RS01810	COG1983	PspC domain protein
FK538_RS01835	COG0318	PFAM AMP-dependent synthetase and ligase
FK538_RS01840	COG1530	ribonuclease E activity
FK538_RS01850	COG0546	phosphoglycolate phosphatase activity
FK538_RS01855	COG3971	2-oxopent-4-enoate hydratase activity
FK538_RS01860	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FK538_RS01885	COG0583	DNA-binding transcription factor activity
FK538_RS01890	COG4638	Rieske (2fe-2S)
FK538_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS01910	COG3384	dioxygenase
FK538_RS01915	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK538_RS01930	COG0753	catalase activity
FK538_RS01940	COG1960	acyl-CoA dehydrogenase activity
FK538_RS01960	COG0494	nUDIX hydrolase
FK538_RS01975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK538_RS01990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FK538_RS02005	COG0473	3-isopropylmalate dehydrogenase activity
FK538_RS02060	COG1560	Kdo2-lipid A biosynthetic process
FK538_RS02070	COG2900	Belongs to the SlyX family
FK538_RS02100	COG1929	Belongs to the glycerate kinase type-1 family
FK538_RS02110	COG0210	DNA helicase
FK538_RS02115	COG0724	RNA recognition motif
FK538_RS02130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FK538_RS02130	COG4651	solute:proton antiporter activity
FK538_RS02155	COG0788	formyltetrahydrofolate deformylase activity
FK538_RS02185	COG1295	ribonuclease BN
FK538_RS02235	COG1702	phosphate starvation-inducible protein PhoH
FK538_RS02245	COG0741	lytic transglycosylase activity
FK538_RS02245	COG0739	heme binding
FK538_RS02245	COG1196	nuclear chromosome segregation
FK538_RS02260	COG3385	transposase activity
FK538_RS02290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FK538_RS02295	COG1183	phosphatidylcholine synthase activity
FK538_RS02360	COG1607	acyl-coa hydrolase
FK538_RS02370	COG1666	GTP binding
FK538_RS02390	COG2350	Protein conserved in bacteria
FK538_RS02400	COG0613	PHP domain protein
FK538_RS02405	COG3781	membrane
FK538_RS02415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FK538_RS02425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FK538_RS02435	COG1162	GTPase activity
FK538_RS02440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FK538_RS02460	COG3209	COG3209 Rhs family protein
FK538_RS02530	COG1136	(ABC) transporter
FK538_RS02530	COG0577	efflux transmembrane transporter activity
FK538_RS02535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK538_RS02560	COG0028	Belongs to the TPP enzyme family
FK538_RS02565	COG0440	acetolactate synthase activity
FK538_RS02605	COG2975	iron-sulfur cluster assembly
FK538_RS02635	COG0124	histidyl-tRNA synthetase
FK538_RS02645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK538_RS02660	COG3956	TIGRFAM MazG family protein
FK538_RS02665	COG1555	photosystem II stabilization
FK538_RS02670	COG0617	tRNA 3'-terminal CCA addition
FK538_RS02675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FK538_RS02690	COG1660	Displays ATPase and GTPase activities
FK538_RS02700	COG3028	Belongs to the UPF0307 family
FK538_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
FK538_RS02720	COG0625	glutathione transferase activity
FK538_RS02725	COG1238	metal cluster binding
FK538_RS02760	COG0072	phenylalanine-tRNA ligase activity
FK538_RS02785	COG0248	Ppx GppA phosphatase
FK538_RS02795	COG0037	tRNA processing
FK538_RS02840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK538_RS02895	COG2969	positive regulation of protein catabolic process
FK538_RS02900	COG0625	glutathione transferase activity
FK538_RS02905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FK538_RS02915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FK538_RS02920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK538_RS02925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FK538_RS02955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FK538_RS02965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK538_RS02970	COG1408	metallophosphoesterase
FK538_RS02980	COG0477	Major facilitator Superfamily
FK538_RS02985	COG1272	protein, Hemolysin III
FK538_RS03010	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK538_RS03010	COG1024	Enoyl-CoA hydratase
FK538_RS03015	COG0183	Belongs to the thiolase family
FK538_RS03020	COG2207	Transcriptional regulator
FK538_RS03030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK538_RS03045	COG0183	Belongs to the thiolase family
FK538_RS03065	COG0833	amino acid
FK538_RS03075	COG2233	PERMEase
FK538_RS03085	COG1970	mechanosensitive ion channel activity
FK538_RS03090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK538_RS03100	COG1877	trehalose-phosphatase activity
FK538_RS03105	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FK538_RS03115	COG0363	glucosamine-6-phosphate deaminase activity
FK538_RS03145	COG0354	folic acid binding
FK538_RS03180	COG0346	lactoylglutathione lyase activity
FK538_RS03185	COG0564	pseudouridine synthase activity
FK538_RS03200	COG3189	MarR family transcriptional regulator
FK538_RS03205	COG2824	Alkylphosphonate utilization operon protein PhnA
FK538_RS03265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FK538_RS03285	COG0730	response to heat
FK538_RS03295	COG1196	nuclear chromosome segregation
FK538_RS03300	COG3115	cell septum assembly
FK538_RS03305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FK538_RS03310	COG2193	ferroxidase activity
FK538_RS03315	COG2226	methyltransferase
FK538_RS03315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK538_RS03315	COG0596	Alpha beta hydrolase
FK538_RS03330	COG4106	trans-aconitate 2-methyltransferase activity
FK538_RS03345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FK538_RS03350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FK538_RS03360	COG0009	L-threonylcarbamoyladenylate synthase
FK538_RS03365	COG3101	peptidyl-lysine hydroxylation
FK538_RS03370	COG1399	metal-binding, possibly nucleic acid-binding protein
FK538_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS03395	COG1652	LysM domain
FK538_RS03400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK538_RS03415	COG0745	RESPONSE REGULATOR receiver
FK538_RS03420	COG2205	protein histidine kinase activity
FK538_RS03425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK538_RS03440	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK538_RS03455	COG3338	carbonate dehydratase activity
FK538_RS03460	COG1126	abc transporter atp-binding protein
FK538_RS03465	COG0765	amino acid transport
FK538_RS03470	COG0765	amino acid transport
FK538_RS03485	COG2323	membrane
FK538_RS03500	COG2852	Protein conserved in bacteria
FK538_RS03525	COG0525	valine-tRNA ligase activity
FK538_RS03540	COG0393	Putative heavy-metal-binding
FK538_RS03545	COG0393	Putative heavy-metal-binding
FK538_RS03550	COG1538	Outer membrane efflux protein
FK538_RS03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK538_RS03565	COG0671	phosphoesterase, PA-phosphatase related
FK538_RS03590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FK538_RS03600	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FK538_RS03605	COG1648	precorrin-2 dehydrogenase activity
FK538_RS03605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FK538_RS03610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FK538_RS03615	COG0531	amino acid
FK538_RS03630	COG0321	lipoyl(octanoyl) transferase activity
FK538_RS03665	COG0586	Pfam SNARE associated Golgi protein
FK538_RS03705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK538_RS03735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FK538_RS03750	COG0358	DNA primase activity
FK538_RS03760	COG0564	pseudouridine synthase activity
FK538_RS03775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FK538_RS03785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK538_RS03815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FK538_RS03815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK538_RS03830	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FK538_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS03860	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FK538_RS03865	COG1053	succinate dehydrogenase
FK538_RS03870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK538_RS03885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK538_RS03895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK538_RS03905	COG1649	PFAM Uncharacterised BCR, COG1649
FK538_RS03905	COG0726	polysaccharide deacetylase
FK538_RS03910	COG1215	transferase activity, transferring glycosyl groups
FK538_RS03920	COG2268	Band 7 protein
FK538_RS03935	COG2354	Protein conserved in bacteria
FK538_RS03940	COG2321	neutral zinc metallopeptidase
FK538_RS03950	COG0589	response to stress
FK538_RS03955	COG0110	maltose O-acetyltransferase activity
FK538_RS03960	COG0251	oxidation-reduction process
FK538_RS03965	COG1309	transcriptional regulator
FK538_RS03980	COG0505	Belongs to the CarA family
FK538_RS03995	COG1534	Rna-binding protein
FK538_RS04005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK538_RS04015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FK538_RS04050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FK538_RS04070	COG1597	lipid kinase activity
FK538_RS04105	COG2239	Acts as a magnesium transporter
FK538_RS04115	COG0501	Belongs to the peptidase M48B family
FK538_RS04120	COG0739	heme binding
FK538_RS04120	COG0741	lytic transglycosylase activity
FK538_RS04120	COG1196	nuclear chromosome segregation
FK538_RS04125	COG0037	tRNA processing
FK538_RS04135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FK538_RS04140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK538_RS04155	COG1840	ABC-type Fe3 transport system, periplasmic component
FK538_RS04160	COG3842	ATPase activity
FK538_RS04165	COG1741	Belongs to the pirin family
FK538_RS04175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FK538_RS04180	COG3739	integral membrane protein
FK538_RS04195	COG3706	GGDEF domain
FK538_RS04225	COG0512	Glutamine amidotransferase of anthranilate synthase
FK538_RS04230	COG0174	glutamine synthetase
FK538_RS04240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FK538_RS04250	COG0583	DNA-binding transcription factor activity
FK538_RS04285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FK538_RS04290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FK538_RS04315	COG1115	amino acid carrier protein
FK538_RS04320	COG1113	amino acid transport
FK538_RS04330	COG0019	diaminopimelate decarboxylase activity
FK538_RS04345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FK538_RS04355	COG1522	sequence-specific DNA binding
FK538_RS04360	COG1280	lysine exporter protein (LysE YggA)
FK538_RS04405	COG1671	Belongs to the UPF0178 family
FK538_RS04420	COG4591	ABC-type transport system involved in lipoprotein release permease component
FK538_RS04425	COG1136	(ABC) transporter
FK538_RS04430	COG0658	competence protein
FK538_RS04430	COG2333	competence protein COMEC
FK538_RS04450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FK538_RS04455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FK538_RS04460	COG0628	permease
FK538_RS04465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK538_RS04495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK538_RS04510	COG3385	transposase activity
FK538_RS04520	COG0823	Involved in the tonB-independent uptake of proteins
FK538_RS04540	COG0824	Thioesterase
FK538_RS04545	COG1473	amidohydrolase
FK538_RS04560	COG2255	four-way junction helicase activity
FK538_RS04580	COG0047	phosphoribosylformylglycinamidine synthase activity
FK538_RS04580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FK538_RS04595	COG0778	Nitroreductase
FK538_RS04600	COG1024	Enoyl-CoA hydratase
FK538_RS04605	COG1056	cytidyltransferase-related domain
FK538_RS04605	COG1051	belongs to the nudix hydrolase family
FK538_RS04610	COG2353	YceI-like domain
FK538_RS04615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FK538_RS04625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FK538_RS04630	COG0602	queuosine metabolic process
FK538_RS04650	COG0583	DNA-binding transcription factor activity
FK538_RS04655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FK538_RS04660	COG4208	sulfate ABC transporter
FK538_RS04675	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FK538_RS04685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FK538_RS04700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK538_RS04710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FK538_RS04725	COG0681	Belongs to the peptidase S26 family
FK538_RS04735	COG0571	ribonuclease III activity
FK538_RS04740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FK538_RS04750	COG1381	Involved in DNA repair and RecF pathway recombination
FK538_RS04755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FK538_RS04780	COG0436	Aminotransferase
FK538_RS04800	COG0556	nucleotide-excision repair
FK538_RS04830	COG0702	epimerase
FK538_RS04835	COG1733	regulation of RNA biosynthetic process
FK538_RS04840	COG2814	Major facilitator Superfamily
FK538_RS04850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FK538_RS04860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FK538_RS04865	COG0076	glutamate decarboxylase activity
FK538_RS04875	COG0573	inorganic phosphate transmembrane transporter activity
FK538_RS04885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FK538_RS04890	COG0616	signal peptide processing
FK538_RS04930	COG1929	Belongs to the glycerate kinase type-1 family
FK538_RS04935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK538_RS04940	COG1686	Belongs to the peptidase S11 family
FK538_RS04955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FK538_RS04965	COG0583	DNA-binding transcription factor activity
FK538_RS04970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK538_RS04975	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FK538_RS04980	COG1067	ATP-dependent peptidase activity
FK538_RS05015	COG1509	lysine 2,3-aminomutase activity
FK538_RS05020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FK538_RS05025	COG1966	Carbon starvation protein
FK538_RS05030	COG2879	small protein
FK538_RS05035	COG0714	Associated with various cellular activities
FK538_RS05065	COG2252	PERMEase
FK538_RS05070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FK538_RS05080	COG1215	transferase activity, transferring glycosyl groups
FK538_RS05090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FK538_RS05100	COG0527	aspartate kinase activity
FK538_RS05110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FK538_RS05125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FK538_RS05130	COG0501	Belongs to the peptidase M48B family
FK538_RS05145	COG0667	Aldo Keto reductase
FK538_RS05155	COG1765	OsmC-like protein
FK538_RS05175	COG0540	Belongs to the ATCase OTCase family
FK538_RS05190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FK538_RS05205	COG4770	biotin carboxylase activity
FK538_RS05210	COG1024	Enoyl-CoA hydratase
FK538_RS05215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FK538_RS05220	COG1960	acyl-CoA dehydrogenase activity
FK538_RS05225	COG1309	transcriptional regulator
FK538_RS05230	COG0318	PFAM AMP-dependent synthetase and ligase
FK538_RS05250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FK538_RS05260	COG0659	secondary active sulfate transmembrane transporter activity
FK538_RS05270	COG3385	transposase activity
FK538_RS05285	COG2363	Small membrane protein
FK538_RS05305	COG0513	Belongs to the DEAD box helicase family
FK538_RS05370	COG4783	chaperone-mediated protein folding
FK538_RS05385	COG1610	YqeY-like protein
FK538_RS05415	COG2815	serine threonine protein kinase
FK538_RS05415	COG0515	serine threonine protein kinase
FK538_RS05455	COG2755	lipolytic protein G-D-S-L family
FK538_RS05455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FK538_RS05460	COG0436	Aminotransferase
FK538_RS05465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK538_RS05470	COG0386	Belongs to the glutathione peroxidase family
FK538_RS05480	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FK538_RS05495	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FK538_RS05505	COG0012	GTP binding
FK538_RS05545	COG0204	Acyl-transferase
FK538_RS05555	COG0582	viral genome integration into host DNA
FK538_RS05580	COG3586	endonuclease activity
FK538_RS05615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FK538_RS05620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FK538_RS05625	COG0022	dehydrogenase e1 component
FK538_RS05630	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK538_RS05635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK538_RS05670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK538_RS05675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK538_RS05685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK538_RS05700	COG2986	histidine ammonia-lyase
FK538_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS05745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK538_RS05775	COG0579	oxidoreductase
FK538_RS05840	COG5001	Diguanylate cyclase
FK538_RS05840	COG5002	protein histidine kinase activity
FK538_RS05855	COG0783	Belongs to the Dps family
FK538_RS05860	COG2814	Major facilitator Superfamily
FK538_RS05865	COG2030	dehydratase
FK538_RS05865	COG1012	belongs to the aldehyde dehydrogenase family
FK538_RS05870	COG3396	Phenylacetate-CoA oxygenase
FK538_RS05875	COG3460	Phenylacetate-CoA oxygenase
FK538_RS05880	COG3396	Phenylacetate-CoA oxygenase
FK538_RS05885	COG2151	metal-sulfur cluster biosynthetic enzyme
FK538_RS05890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK538_RS05895	COG1024	Enoyl-CoA hydratase
FK538_RS05900	COG1024	Enoyl-CoA hydratase
FK538_RS05905	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK538_RS05910	COG0183	Belongs to the thiolase family
FK538_RS05915	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FK538_RS05920	COG3327	negative regulation of DNA-templated transcription, initiation
FK538_RS05930	COG0318	PFAM AMP-dependent synthetase and ligase
FK538_RS05950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FK538_RS05955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FK538_RS05955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FK538_RS05960	COG1254	Belongs to the acylphosphatase family
FK538_RS06000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FK538_RS06005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FK538_RS06015	COG2353	YceI-like domain
FK538_RS06020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK538_RS06020	COG0519	Catalyzes the synthesis of GMP from XMP
FK538_RS06040	COG1454	alcohol dehydrogenase
FK538_RS06050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK538_RS06055	COG0583	DNA-binding transcription factor activity
FK538_RS06065	COG2707	UPF0756 membrane protein
FK538_RS06090	COG0802	atpase or kinase
FK538_RS06095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FK538_RS06105	COG1923	regulation of RNA biosynthetic process
FK538_RS06110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK538_RS06120	COG3178	'Phosphotransferase
FK538_RS06125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FK538_RS06135	COG1192	Involved in chromosome partitioning
FK538_RS06140	COG1475	DNA binding
FK538_RS06145	COG0811	peptide transport
FK538_RS06155	COG1132	(ABC) transporter
FK538_RS06160	COG1663	tetraacyldisaccharide 4'-kinase activity
FK538_RS06180	COG0084	hydrolase, TatD family'
FK538_RS06215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FK538_RS06245	COG0776	regulation of translation
FK538_RS06255	COG0284	orotidine-5'-phosphate decarboxylase activity
FK538_RS06260	COG2431	L-lysine efflux transmembrane transporter activity
FK538_RS06275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FK538_RS06280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FK538_RS06300	COG1253	flavin adenine dinucleotide binding
FK538_RS06330	COG0583	DNA-binding transcription factor activity
FK538_RS06340	COG2204	response regulator
FK538_RS06345	COG3852	Histidine kinase
FK538_RS06360	COG0233	cytoplasmic translational termination
FK538_RS06365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FK538_RS06370	COG0575	Belongs to the CDS family
FK538_RS06405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK538_RS06435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK538_RS06440	COG0730	response to heat
FK538_RS06445	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK538_RS06450	COG2207	Transcriptional regulator
FK538_RS06455	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK538_RS06465	COG1960	acyl-CoA dehydrogenase activity
FK538_RS06470	COG1960	acyl-CoA dehydrogenase activity
FK538_RS06505	COG4890	Cyd operon protein YbgT
FK538_RS06510	COG1294	oxidase, subunit
FK538_RS06525	COG1585	Membrane protein implicated in regulation of membrane protease activity
FK538_RS06535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK538_RS06555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FK538_RS06560	COG0569	domain protein
FK538_RS06570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FK538_RS06590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FK538_RS06595	COG0542	response to heat
FK538_RS06610	COG0477	Major facilitator Superfamily
FK538_RS06630	COG0372	Belongs to the citrate synthase family
FK538_RS06640	COG1546	Belongs to the CinA family
FK538_RS06640	COG1058	Belongs to the CinA family
FK538_RS06705	COG2814	Major facilitator Superfamily
FK538_RS06720	COG0439	Biotin carboxylase
FK538_RS06725	COG0511	ligase activity, forming carbon-carbon bonds
FK538_RS06760	COG0596	Alpha beta hydrolase
FK538_RS06915	COG1309	transcriptional regulator
FK538_RS06935	COG0730	response to heat
FK538_RS06940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK538_RS06945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FK538_RS06955	COG2885	chlorophyll binding
FK538_RS06975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK538_RS06985	COG0745	RESPONSE REGULATOR receiver
FK538_RS07005	COG1012	belongs to the aldehyde dehydrogenase family
FK538_RS07010	COG1309	transcriptional regulator
FK538_RS07015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FK538_RS07050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK538_RS07065	COG0515	serine threonine protein kinase
FK538_RS07070	COG2116	formate transmembrane transporter activity
FK538_RS07075	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FK538_RS07085	COG2223	nitrite transmembrane transporter activity
FK538_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS07125	COG2814	Major facilitator Superfamily
FK538_RS07130	COG0583	DNA-binding transcription factor activity
FK538_RS07135	COG4948	Mandelate Racemase Muconate Lactonizing
FK538_RS07140	COG4829	muconolactone delta-isomerase
FK538_RS07150	COG4638	Rieske (2fe-2S)
FK538_RS07155	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FK538_RS07160	COG0543	2 iron, 2 sulfur cluster binding
FK538_RS07160	COG0633	Ferredoxin
FK538_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS07170	COG3135	benzoate transporter
FK538_RS07175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FK538_RS07180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FK538_RS07185	COG0183	Belongs to the thiolase family
FK538_RS07190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK538_RS07210	COG0583	DNA-binding transcription factor activity
FK538_RS07215	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FK538_RS07220	COG4149	molybdate abc transporter
FK538_RS07230	COG0303	'Molybdopterin
FK538_RS07235	COG0521	Mo-molybdopterin cofactor biosynthetic process
FK538_RS07235	COG0315	cyclic pyranopterin monophosphate synthase activity
FK538_RS07250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FK538_RS07260	COG0243	molybdopterin cofactor binding
FK538_RS07265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK538_RS07270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK538_RS07275	COG2223	nitrite transmembrane transporter activity
FK538_RS07285	COG1116	anion transmembrane transporter activity
FK538_RS07285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK538_RS07290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK538_RS07295	COG2937	Belongs to the GPAT DAPAT family
FK538_RS07300	COG0640	Transcriptional regulator
FK538_RS07320	COG3122	Protein conserved in bacteria
FK538_RS07325	COG0668	transmembrane transport
FK538_RS07340	COG1132	(ABC) transporter
FK538_RS07360	COG2814	Major facilitator Superfamily
FK538_RS07370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK538_RS07380	COG1113	amino acid transport
FK538_RS07395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FK538_RS07400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK538_RS07450	COG1525	nuclease
FK538_RS07465	COG1271	oxidase subunit
FK538_RS07475	COG2814	Major facilitator Superfamily
FK538_RS07480	COG1917	Cupin 2, conserved barrel domain protein
FK538_RS07480	COG2207	Transcriptional regulator
FK538_RS07485	COG1960	acyl-CoA dehydrogenase activity
FK538_RS07495	COG1629	transport
FK538_RS07510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK538_RS07515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FK538_RS07535	COG0583	DNA-binding transcription factor activity
FK538_RS07545	COG1346	cytolysis
FK538_RS07555	COG1283	sodium-dependent phosphate transmembrane transporter activity
FK538_RS07565	COG0693	protein deglycase activity
FK538_RS07610	COG0552	protein localization to endoplasmic reticulum
FK538_RS07615	COG0612	Peptidase, M16
FK538_RS07645	COG0617	tRNA 3'-terminal CCA addition
FK538_RS07645	COG0517	IMP dehydrogenase activity
FK538_RS07645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK538_RS07650	COG0133	tryptophan synthase activity
FK538_RS07660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK538_RS07680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FK538_RS07735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK538_RS07765	COG0822	iron-sulfur transferase activity
FK538_RS07770	COG0316	Belongs to the HesB IscA family
FK538_RS07800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FK538_RS07815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FK538_RS07820	COG0702	epimerase
FK538_RS07850	COG1011	Hydrolase
FK538_RS07855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FK538_RS07865	COG2137	regulation of response to DNA damage stimulus
FK538_RS07880	COG0772	Belongs to the SEDS family
FK538_RS07895	COG0148	phosphopyruvate hydratase activity
FK538_RS07915	COG0583	DNA-binding transcription factor activity
FK538_RS07925	COG2814	Major facilitator Superfamily
FK538_RS07940	COG1902	pentaerythritol trinitrate reductase activity
FK538_RS07940	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK538_RS07955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FK538_RS07960	COG2814	Major facilitator Superfamily
FK538_RS07965	COG1960	acyl-CoA dehydrogenase activity
FK538_RS07970	COG0583	DNA-binding transcription factor activity
FK538_RS07975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FK538_RS07980	COG1027	Aspartate ammonia-lyase
FK538_RS07985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK538_RS07995	COG0506	proline dehydrogenase activity
FK538_RS07995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK538_RS07995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK538_RS08015	COG3698	Phosphodiester glycosidase
FK538_RS08055	COG0697	spore germination
FK538_RS08080	COG0424	maF-like protein
FK538_RS08085	COG2850	peptidyl-arginine hydroxylation
FK538_RS08090	COG4585	Histidine kinase
FK538_RS08100	COG0069	glutamate synthase activity
FK538_RS08120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FK538_RS08125	COG1454	alcohol dehydrogenase
FK538_RS08130	COG0824	Thioesterase
FK538_RS08150	COG2030	dehydratase
FK538_RS08160	COG0183	Belongs to the thiolase family
FK538_RS08175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK538_RS08185	COG3135	benzoate transporter
FK538_RS08195	COG0589	response to stress
FK538_RS08200	COG0589	response to stress
FK538_RS08210	COG0308	aminopeptidase N
FK538_RS08240	COG0786	glutamate:sodium symporter activity
FK538_RS08290	COG0477	Major facilitator Superfamily
FK538_RS08305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FK538_RS08315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FK538_RS08325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK538_RS08330	COG1960	acyl-CoA dehydrogenase activity
FK538_RS08350	COG3781	membrane
FK538_RS08360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK538_RS08375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK538_RS08400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FK538_RS08405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK538_RS08410	COG1845	cytochrome c oxidase, subunit III
FK538_RS08415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FK538_RS08425	COG0360	Binds together with S18 to 16S ribosomal RNA
FK538_RS08430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FK538_RS08445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FK538_RS08460	COG1305	Transglutaminase-like
FK538_RS08470	COG2308	Evidence 4 Homologs of previously reported genes of
FK538_RS08510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FK538_RS08515	COG0138	bifunctional purine biosynthesis protein purh
FK538_RS08535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FK538_RS08540	COG2011	ABC-type metal ion transport system permease component
FK538_RS08575	COG1454	alcohol dehydrogenase
FK538_RS08590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FK538_RS08600	COG4122	O-methyltransferase activity
FK538_RS08625	COG2274	protein secretion by the type I secretion system
FK538_RS08635	COG1137	ATPase activity
FK538_RS08640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FK538_RS08650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FK538_RS08655	COG0517	IMP dehydrogenase activity
FK538_RS08655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FK538_RS08680	COG1643	Atp-dependent helicase
FK538_RS08710	COG3634	alkyl hydroperoxide reductase activity
FK538_RS08720	COG3385	transposase activity
FK538_RS08745	COG2070	2-Nitropropane dioxygenase
FK538_RS08760	COG1278	Cold shock
FK538_RS08795	COG1309	transcriptional regulator
FK538_RS08800	COG0596	Alpha beta hydrolase
FK538_RS08835	COG2433	Pfam Transposase IS66
FK538_RS08860	COG0352	thiamine-phosphate diphosphorylase activity
FK538_RS08895	COG0612	Peptidase, M16
FK538_RS08905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK538_RS08915	COG0739	heme binding
FK538_RS08930	COG1187	pseudouridine synthase activity
FK538_RS08945	COG1686	Belongs to the peptidase S11 family
FK538_RS08950	COG1252	NADH dehydrogenase
FK538_RS08955	COG1047	Peptidyl-prolyl cis-trans
FK538_RS08980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FK538_RS08985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FK538_RS08995	COG0693	protein deglycase activity
FK538_RS09000	COG1960	acyl-CoA dehydrogenase activity
FK538_RS09005	COG1301	dicarboxylic acid transport
FK538_RS09015	COG3139	Protein of unknown function (DUF1315)
FK538_RS09020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FK538_RS09025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK538_RS09045	COG0642	Histidine kinase
FK538_RS09050	COG0745	RESPONSE REGULATOR receiver
FK538_RS09060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FK538_RS09075	COG2963	transposase activity
FK538_RS09085	COG4372	Transposase
FK538_RS09095	COG1720	tRNA m6t6A37 methyltransferase activity
FK538_RS09120	COG0789	Transcriptional regulator
FK538_RS09125	COG0431	NADPH-dependent FMN reductase
FK538_RS09130	COG0798	PFAM Bile acid sodium symporter
FK538_RS09140	COG0640	Transcriptional regulator
FK538_RS09155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK538_RS09160	COG3634	alkyl hydroperoxide reductase activity
FK538_RS09180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK538_RS09235	COG1131	(ABC) transporter
FK538_RS09240	COG0842	Transport permease protein
FK538_RS09255	COG2951	lytic endotransglycosylase activity
FK538_RS09280	COG0052	Belongs to the universal ribosomal protein uS2 family
FK538_RS09300	COG2175	clavaminate synthase activity
FK538_RS09310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FK538_RS09335	COG1473	amidohydrolase
FK538_RS09345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FK538_RS09350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FK538_RS09355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK538_RS09375	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FK538_RS09405	COG2871	sodium ion transport
FK538_RS09420	COG0582	viral genome integration into host DNA
FK538_RS09500	COG4372	Transposase
FK538_RS09560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FK538_RS09610	COG2801	Transposase and inactivated derivatives
FK538_RS09645	COG2184	nucleotidyltransferase activity
FK538_RS09690	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK538_RS09690	COG1902	pentaerythritol trinitrate reductase activity
FK538_RS09705	COG3706	GGDEF domain
FK538_RS09705	COG2203	Gaf domain
FK538_RS09705	COG5001	Diguanylate cyclase
FK538_RS09705	COG4251	negative regulation of phosphorylation
FK538_RS09710	COG0418	dihydroorotase activity
FK538_RS09715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK538_RS09740	COG0833	amino acid
FK538_RS09770	COG4172	Belongs to the ABC transporter superfamily
FK538_RS09775	COG4239	(ABC) transporter, permease
FK538_RS09780	COG4174	ABC transporter (Permease)
FK538_RS09785	COG4166	transmembrane transport
FK538_RS09790	COG1388	LysM domain
FK538_RS09790	COG0741	lytic transglycosylase activity
FK538_RS09795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK538_RS09805	COG2816	NAD+ diphosphatase activity
FK538_RS09840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK538_RS09845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK538_RS09850	COG0006	proline dipeptidase activity
FK538_RS09855	COG3079	Belongs to the UPF0149 family
FK538_RS09890	COG0277	FAD linked oxidase domain protein
FK538_RS09900	COG2186	Transcriptional regulator
FK538_RS09935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FK538_RS09945	COG2234	aminopeptidase activity
FK538_RS09955	COG3384	dioxygenase
FK538_RS09965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FK538_RS09970	COG2878	Part of a membrane complex involved in electron transport
FK538_RS09975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FK538_RS10000	COG0768	penicillin binding
FK538_RS10005	COG0742	ribosomal rna small subunit methyltransferase
FK538_RS10020	COG0830	nickel cation binding
FK538_RS10035	COG0804	urea catabolic process
FK538_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS10070	COG3015	lipoprotein NlpE involved in copper resistance
FK538_RS10090	COG1253	flavin adenine dinucleotide binding
FK538_RS10110	COG3321	synthase
FK538_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS10110	COG0604	alcohol dehydrogenase
FK538_RS10115	COG3118	belongs to the thioredoxin family
FK538_RS10155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FK538_RS10160	COG1773	rubredoxin
FK538_RS10165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK538_RS10175	COG0583	DNA-binding transcription factor activity
FK538_RS10185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK538_RS10195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FK538_RS10200	COG4181	ATPase activity
FK538_RS10225	COG4771	TonB-dependent receptor
FK538_RS10250	COG0306	phosphate transporter
FK538_RS10265	COG0477	Major facilitator Superfamily
FK538_RS10295	COG2203	Gaf domain
FK538_RS10295	COG2199	diguanylate cyclase activity
FK538_RS10305	COG4681	YaeQ
FK538_RS10310	COG0523	cobalamin synthesis protein
FK538_RS10340	COG0583	DNA-binding transcription factor activity
FK538_RS10345	COG2814	Major facilitator Superfamily
FK538_RS10355	COG1607	acyl-coa hydrolase
FK538_RS10365	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK538_RS10370	COG2059	Chromate
FK538_RS10375	COG1115	amino acid carrier protein
FK538_RS10380	COG0786	glutamate:sodium symporter activity
FK538_RS10395	COG2814	Major facilitator Superfamily
FK538_RS10400	COG1289	transmembrane transporter activity
FK538_RS10410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FK538_RS10465	COG1376	ErfK ybiS ycfS ynhG family protein
FK538_RS10470	COG2832	Protein of unknown function (DUF454)
FK538_RS10480	COG5510	response to toxic substance
FK538_RS10495	COG0643	Histidine kinase
FK538_RS10495	COG0784	Response regulator, receiver
FK538_RS10495	COG2198	Histidine kinase
FK538_RS10500	COG0840	transmembrane signaling receptor activity
FK538_RS10535	COG0442	prolyl-tRNA aminoacylation
FK538_RS10570	COG2358	TRAP transporter, solute receptor (TAXI family
FK538_RS10585	COG0489	protein tyrosine kinase activity
FK538_RS10590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK538_RS10590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK538_RS10625	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FK538_RS10640	COG2081	HI0933 family
FK538_RS10655	COG0668	transmembrane transport
FK538_RS10680	COG0583	DNA-binding transcription factor activity
FK538_RS10685	COG1278	Cold shock
FK538_RS10690	COG1278	Cold shock
FK538_RS10705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK538_RS10710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK538_RS10715	COG0713	ATP synthesis coupled electron transport
FK538_RS10720	COG0839	Belongs to the complex I subunit 6 family
FK538_RS10725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK538_RS10730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FK538_RS10740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FK538_RS10760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK538_RS10770	COG0142	geranyltranstransferase activity
FK538_RS10775	COG2828	Protein conserved in bacteria
FK538_RS10780	COG1113	amino acid transport
FK538_RS10800	COG0625	glutathione transferase activity
FK538_RS10840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FK538_RS10850	COG1530	ribonuclease E activity
FK538_RS10855	COG0424	maF-like protein
FK538_RS10860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FK538_RS10865	COG1792	Involved in formation and maintenance of cell shape
FK538_RS10870	COG1077	Cell shape determining protein MreB Mrl
FK538_RS10875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK538_RS10885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK538_RS10900	COG0697	spore germination
FK538_RS10915	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FK538_RS10930	COG1215	transferase activity, transferring glycosyl groups
FK538_RS10935	COG1649	PFAM Uncharacterised BCR, COG1649
FK538_RS10935	COG0726	polysaccharide deacetylase
FK538_RS10965	COG3177	Filamentation induced by cAMP protein fic
FK538_RS11015	COG1802	Transcriptional regulator
FK538_RS11030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FK538_RS11035	COG3385	transposase activity
FK538_RS11040	COG2050	protein possibly involved in aromatic compounds catabolism
FK538_RS11060	COG0420	3'-5' exonuclease activity
FK538_RS11090	COG0735	belongs to the Fur family
FK538_RS11095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK538_RS11100	COG2914	Belongs to the UPF0125 (RnfH) family
FK538_RS11115	COG0121	glutamine amidotransferase
FK538_RS11130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK538_RS11140	COG0210	DNA helicase
FK538_RS11145	COG2885	chlorophyll binding
FK538_RS11150	COG0204	Acyl-transferase
FK538_RS11160	COG0850	regulation of cytokinetic process
FK538_RS11165	COG2894	cell division
FK538_RS11180	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK538_RS11180	COG1674	ftsk spoiiie
FK538_RS11185	COG0492	ferredoxin-NADP+ reductase activity
FK538_RS11190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FK538_RS11200	COG0456	acetyltransferase
FK538_RS11225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FK538_RS11245	COG1113	amino acid transport
FK538_RS11250	COG0251	oxidation-reduction process
FK538_RS11275	COG0351	phosphomethylpyrimidine kinase
FK538_RS11275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK538_RS11275	COG0352	thiamine-phosphate diphosphorylase activity
FK538_RS11290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FK538_RS11295	COG2076	Multidrug Resistance protein
FK538_RS11305	COG2132	Multicopper oxidase
FK538_RS11315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK538_RS11330	COG4269	membrane
FK538_RS11350	COG1968	undecaprenyl-diphosphatase activity
FK538_RS11355	COG1214	PFAM Peptidase M22, glycoprotease
FK538_RS11365	COG0494	nUDIX hydrolase
FK538_RS11415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FK538_RS11420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FK538_RS11480	COG2199	diguanylate cyclase activity
FK538_RS11510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FK538_RS11515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FK538_RS11530	COG0450	alkyl hydroperoxide reductase
FK538_RS11545	COG0285	dihydrofolate synthase activity
FK538_RS11550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FK538_RS11595	COG4206	TonB-dependent receptor
FK538_RS11600	COG2096	Adenosyltransferase
FK538_RS11620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FK538_RS11625	COG2315	Protein conserved in bacteria
FK538_RS11635	COG0745	RESPONSE REGULATOR receiver
FK538_RS11640	COG2205	protein histidine kinase activity
FK538_RS11650	COG1960	acyl-CoA dehydrogenase activity
FK538_RS11655	COG1960	acyl-CoA dehydrogenase activity
FK538_RS11660	COG3223	Belongs to the PsiE family
FK538_RS11690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FK538_RS11705	COG1215	transferase activity, transferring glycosyl groups
FK538_RS11740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FK538_RS11745	COG5002	protein histidine kinase activity
FK538_RS11760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FK538_RS11770	COG1704	LemA family
FK538_RS11785	COG1862	Preprotein translocase
FK538_RS11805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK538_RS11820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK538_RS11825	COG5002	protein histidine kinase activity
FK538_RS11825	COG2205	protein histidine kinase activity
FK538_RS11825	COG0784	Response regulator, receiver
FK538_RS11830	COG1024	Enoyl-CoA hydratase
FK538_RS11840	COG3622	Belongs to the hyi family
FK538_RS11865	COG0697	spore germination
FK538_RS11870	COG2814	Major facilitator Superfamily
FK538_RS11900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FK538_RS11905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FK538_RS11910	COG0084	hydrolase, TatD family'
FK538_RS11925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FK538_RS11945	COG0793	Belongs to the peptidase S41A family
FK538_RS11975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FK538_RS11980	COG0280	phosphate acetyltransferase
FK538_RS11980	COG0857	belongs to the CobB CobQ family
FK538_RS12000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FK538_RS12000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FK538_RS12015	COG0740	serine-type endopeptidase activity
FK538_RS12025	COG4771	TonB-dependent receptor
FK538_RS12030	COG4774	siderophore transport
FK538_RS12035	COG3128	pkhd-type hydroxylase
FK538_RS12045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FK538_RS12050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK538_RS12055	COG2813	Specifically methylates the guanine in position
FK538_RS12055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK538_RS12115	COG3040	lipid binding
FK538_RS12145	COG0179	Fumarylacetoacetate (FAA) hydrolase
FK538_RS12180	COG0557	exoribonuclease II activity
FK538_RS12185	COG0339	signal peptide processing
FK538_RS12190	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FK538_RS12225	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FK538_RS12230	COG1960	acyl-CoA dehydrogenase activity
FK538_RS12235	COG2072	flavoprotein involved in K transport
FK538_RS12245	COG0202	RNA polymerase activity
FK538_RS12250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FK538_RS12285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FK538_RS12295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FK538_RS12300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FK538_RS12335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FK538_RS12365	COG0088	Forms part of the polypeptide exit tunnel
FK538_RS12390	COG0433	COG0433 Predicted ATPase
FK538_RS12400	COG1959	2 iron, 2 sulfur cluster binding
FK538_RS12420	COG1301	dicarboxylic acid transport
FK538_RS12425	COG1946	Acyl-CoA thioesterase
FK538_RS12430	COG2937	Belongs to the GPAT DAPAT family
FK538_RS12440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FK538_RS12445	COG1040	competence protein
FK538_RS12460	COG0598	Magnesium transport protein CorA
FK538_RS12465	COG3385	transposase activity
FK538_RS12475	COG2854	intermembrane phospholipid transfer
FK538_RS12480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FK538_RS12485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK538_RS12490	COG1127	ABC transporter
FK538_RS12515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK538_RS12535	COG1960	acyl-CoA dehydrogenase activity
FK538_RS12540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK538_RS12550	COG0534	Mate efflux family protein
FK538_RS12555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK538_RS12560	COG0254	rRNA binding
FK538_RS12565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FK538_RS12585	COG2226	methyltransferase
FK538_RS12595	COG0675	Transposase, IS605 OrfB family
FK538_RS12605	COG1192	Involved in chromosome partitioning
FK538_RS12610	COG0628	permease
FK538_RS12620	COG2814	Major facilitator Superfamily
FK538_RS12635	COG0277	FAD linked oxidase domain protein
FK538_RS12640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FK538_RS12665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FK538_RS12670	COG5380	lipid catabolic process
FK538_RS12675	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FK538_RS12700	COG0335	large ribosomal subunit rRNA binding
FK538_RS12710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FK538_RS12715	COG0228	four-way junction DNA binding
FK538_RS12760	COG0194	GDP metabolic process
FK538_RS12765	COG1758	RNA polymerase activity
FK538_RS12770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK538_RS12790	COG3307	-O-antigen
FK538_RS12800	COG4969	Belongs to the N-Me-Phe pilin family
FK538_RS12810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FK538_RS12815	COG1704	LemA family
FK538_RS12825	COG0493	'glutamate synthase
FK538_RS12830	COG0070	glutamate synthase
FK538_RS12830	COG0069	glutamate synthase activity
FK538_RS12830	COG0067	glutamate synthase
FK538_RS12880	COG2226	methyltransferase
FK538_RS12890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FK538_RS12895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK538_RS12910	COG0275	rRNA processing
FK538_RS12915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FK538_RS12925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK538_RS12945	COG0488	(ABC) transporter
FK538_RS12955	COG4221	oxidoreductase activity
FK538_RS12970	COG0745	RESPONSE REGULATOR receiver
FK538_RS12975	COG2205	protein histidine kinase activity
FK538_RS12980	COG0427	acetyl-CoA hydrolase
FK538_RS13010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FK538_RS13045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FK538_RS13085	COG3158	transport of potassium into the cell
FK538_RS13110	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FK538_RS13125	COG0629	single-stranded DNA binding
FK538_RS13130	COG2814	Major facilitator Superfamily
FK538_RS13140	COG0351	phosphomethylpyrimidine kinase
FK538_RS13140	COG0352	thiamine-phosphate diphosphorylase activity
FK538_RS13140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK538_RS13145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK538_RS13150	COG3706	GGDEF domain
FK538_RS13160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FK538_RS13180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK538_RS13185	COG3162	membrane
FK538_RS13190	COG2205	protein histidine kinase activity
FK538_RS13190	COG0784	Response regulator, receiver
FK538_RS13205	COG0431	NADPH-dependent FMN reductase
FK538_RS13215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK538_RS13220	COG0668	transmembrane transport
FK538_RS13225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK538_RS13230	COG1519	Transferase
FK538_RS13235	COG1902	pentaerythritol trinitrate reductase activity
FK538_RS13240	COG0640	Transcriptional regulator
FK538_RS13260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FK538_RS13285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK538_RS13285	COG0426	domain, Protein
FK538_RS13290	COG2119	membrane
FK538_RS13320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FK538_RS13330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FK538_RS13340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK538_RS13345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK538_RS13350	COG0189	ligase activity
FK538_RS13370	COG0708	Exodeoxyribonuclease III
FK538_RS13375	COG1393	Belongs to the ArsC family
FK538_RS13390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FK538_RS13395	COG3706	GGDEF domain
FK538_RS13400	COG0625	glutathione transferase activity
FK538_RS13440	COG1247	-acetyltransferase
FK538_RS13445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK538_RS13450	COG4266	Belongs to the allantoicase family
FK538_RS13455	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FK538_RS13465	COG0471	metal ion transport
FK538_RS13505	COG3150	esterase
FK538_RS13515	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FK538_RS13520	COG2918	glutathione biosynthetic process
FK538_RS13535	COG2733	membrane
FK538_RS13540	COG0436	Aminotransferase
FK538_RS13545	COG0534	Mate efflux family protein
FK538_RS13550	COG2175	clavaminate synthase activity
FK538_RS13595	COG0753	catalase activity
FK538_RS13615	COG0560	Phosphoserine phosphatase
FK538_RS13615	COG3830	Belongs to the UPF0237 family
FK538_RS13630	COG0385	Bile acid
FK538_RS13635	COG1335	isochorismatase
FK538_RS13640	COG2814	Major facilitator Superfamily
FK538_RS13645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FK538_RS13655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FK538_RS13660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FK538_RS13665	COG2983	Belongs to the UPF0260 family
FK538_RS13670	COG5487	UPF0391 membrane protein
FK538_RS13685	COG1194	a g-specific adenine glycosylase
FK538_RS13690	COG0739	heme binding
FK538_RS13700	COG2818	Glycosylase
FK538_RS13705	COG1064	alcohol dehydrogenase
FK538_RS13725	COG3023	N-Acetylmuramoyl-L-alanine amidase
FK538_RS13735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FK538_RS13740	COG1309	transcriptional regulator
FK538_RS13750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FK538_RS13755	COG0546	phosphoglycolate phosphatase activity
FK538_RS13760	COG1028	Short-chain dehydrogenase reductase Sdr
FK538_RS13790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK538_RS13795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK538_RS13800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK538_RS13805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FK538_RS13810	COG1116	anion transmembrane transporter activity
FK538_RS13825	COG1309	transcriptional regulator
FK538_RS13835	COG0196	riboflavin kinase activity
FK538_RS13840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FK538_RS13845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FK538_RS13850	COG1047	Peptidyl-prolyl cis-trans
FK538_RS13860	COG2133	pyrroloquinoline quinone binding
FK538_RS13865	COG2814	Major facilitator Superfamily
FK538_RS13895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK538_RS13940	COG2951	lytic endotransglycosylase activity
FK538_RS13945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FK538_RS13965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK538_RS13985	COG2388	GCN5-related N-acetyl-transferase
FK538_RS13995	COG0861	Integral membrane protein TerC family
FK538_RS14000	COG3385	transposase activity
FK538_RS14005	COG0402	S-adenosylhomocysteine deaminase activity
FK538_RS14025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FK538_RS14030	COG1230	cation diffusion facilitator family transporter
FK538_RS14055	COG0706	membrane insertase activity
FK538_RS14060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FK538_RS14065	COG0594	ribonuclease P activity
FK538_RS14120	COG1373	ATPase (AAA superfamily
FK538_RS14165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FK538_RS14170	COG2132	Multicopper oxidase
FK538_RS14185	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FK538_RS14225	COG2862	Uncharacterized protein family, UPF0114
FK538_RS14235	COG0659	secondary active sulfate transmembrane transporter activity
FK538_RS14345	COG2801	Transposase and inactivated derivatives
FK538_RS14370	COG4974	Belongs to the 'phage' integrase family
FK538_RS14400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK538_RS14480	COG1660	Displays ATPase and GTPase activities
FK538_RS14505	COG0659	secondary active sulfate transmembrane transporter activity
FK538_RS14510	COG0589	response to stress
FK538_RS14515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FK538_RS14525	COG1475	DNA binding
FK538_RS14530	COG1192	Involved in chromosome partitioning