locus-tag class description FK537_RS00095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FK537_RS00150 ENOG4105EJX conjugal transfer ATPase FK537_RS00220 ENOG4107QJE Chromosome Partitioning Protein FK537_RS00285 ENOG4107J0C type IIi FK537_RS00290 ENOG4107QMH DNA methylase FK537_RS00475 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FK537_RS00505 ENOG4105EV9 Alpha Beta Hydrolase FK537_RS00540 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FK537_RS00545 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FK537_RS00560 ENOG4105D8G Major Facilitator superfamily FK537_RS00600 ENOG4105CEV competence damage-inducible protein FK537_RS00610 ENOG4105BZN citrate synthase FK537_RS00615 ENOG4105CR4 methylisocitrate lyase FK537_RS00630 ENOG4105CSH Transporter FK537_RS00645 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FK537_RS00650 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FK537_RS00670 ENOG4105E66 phosphoriboisomerase A FK537_RS00675 ENOG4105C7B Threonine dehydratase FK537_RS00685 ENOG4105CZN Potassium uptake protein FK537_RS00690 ENOG4105HDD phospholipase FK537_RS00715 ENOG4105PV3 Inner membrane protein yqiJ FK537_RS00725 ENOG4105C4M (Ubiquinol oxidase) subunit I FK537_RS00730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FK537_RS00750 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FK537_RS00770 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS00775 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS00780 ENOG4108MJ3 acetyltransferase FK537_RS00785 ENOG4105EEF Alkane 1-monooxygenase FK537_RS00790 ENOG4105E7U AraC family transcriptional regulator FK537_RS00795 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FK537_RS00800 ENOG4107TSN permease FK537_RS00805 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FK537_RS00835 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FK537_RS00855 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FK537_RS00860 ENOG4105DZP Membrane-associated zinc metalloprotease FK537_RS00870 ENOG4105KNE Phosphatidate cytidylyltransferase FK537_RS00875 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FK537_RS00880 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FK537_RS00895 ENOG4105CUX Signal transduction histidine kinase FK537_RS00900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FK537_RS00910 ENOG4105CC0 LysR family Transcriptional regulator FK537_RS00915 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FK537_RS00920 ENOG4105CWM branched-chain amino acid transport system II carrier protein FK537_RS00940 ENOG4105VNT transposase (IS4 family) protein FK537_RS00945 ENOG4105EE5 Membrane protein terC FK537_RS00965 ENOG4107QP3 malate synthase g FK537_RS00970 ENOG4105D6Z AFG1 family ATPase FK537_RS00980 ENOG4107RN6 Monooxygenase FK537_RS00985 ENOG4105DWU Membrane FK537_RS00990 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FK537_RS01000 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FK537_RS01005 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FK537_RS01020 ENOG4108Z6B deaminase FK537_RS01030 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FK537_RS01040 ENOG4108RTD type II secretion system protein K FK537_RS01065 ENOG4105F8V Hydrolase, tatD family FK537_RS01075 ENOG4107QRG dna polymerase iii FK537_RS01085 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FK537_RS01090 ENOG4105BZ1 (ABC) transporter FK537_RS01105 ENOG4105FA0 parb-like partition protein FK537_RS01110 ENOG4107QJE Chromosome Partitioning Protein FK537_RS01120 ENOG4108S0S Nucleotidyl transferase FK537_RS01125 ENOG4105EHM Aminoglycoside phosphotransferase FK537_RS01130 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FK537_RS01135 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FK537_RS01140 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FK537_RS01150 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FK537_RS01155 ENOG4105K8N protein family UPF0079, ATPase FK537_RS01175 ENOG4105I08 Pseudouridine synthase FK537_RS01180 ENOG4108VMM UPF0756 membrane protein FK537_RS01190 ENOG4105DZ2 Transcriptional regulator FK537_RS01195 ENOG4107QUV Domain protein FK537_RS01215 ENOG4107RR1 TRANSCRIPTIONal FK537_RS01225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FK537_RS01230 ENOG4108YYC ycei family FK537_RS01240 ENOG4105CV1 Transketolase (EC 2.2.1.1) FK537_RS01245 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FK537_RS01250 ENOG4105N0V mono-oxygenase ydhR FK537_RS01265 ENOG4105CCF Lysine exporter protein (Lyse ygga) FK537_RS01285 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FK537_RS01290 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FK537_RS01295 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FK537_RS01315 ENOG4105CEY Amp-dependent synthetase and ligase FK537_RS01325 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FK537_RS01330 ENOG4105DZS Phenylacetate-CoA ligase FK537_RS01335 ENOG4105CHU acetyl-coa acetyltransferase FK537_RS01340 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FK537_RS01345 ENOG4108UKI Enoyl-CoA hydratase FK537_RS01350 ENOG4105E39 Enoyl-CoA hydratase FK537_RS01355 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FK537_RS01360 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FK537_RS01365 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FK537_RS01370 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FK537_RS01375 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FK537_RS01380 ENOG4105DXM phenylacetic acid degradation protein FK537_RS01385 ENOG4105DNH Major Facilitator FK537_RS01405 ENOG4105BZU Histidine kinase FK537_RS01415 ENOG4107T32 3-phytase (EC 3.1.3.8) FK537_RS01420 ENOG4105E02 MotA TolQ exbB proton channel FK537_RS01425 ENOG4105M8F Biopolymer transport protein exbD tolR FK537_RS01435 ENOG4105CNM Receptor FK537_RS01470 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FK537_RS01505 ENOG4105DHQ Histidine kinase FK537_RS01520 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FK537_RS01545 ENOG4105E09 nadh pyrophosphatase FK537_RS01550 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein FK537_RS01565 ENOG4105VT2 5-hydroxyisourate hydrolase FK537_RS01600 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FK537_RS01610 ENOG410624X efflux transporter, rnd family, mfp subunit FK537_RS01630 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FK537_RS01635 ENOG4105C2D reductase FK537_RS01645 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FK537_RS01655 ENOG4107T3I fad-binding protein FK537_RS01675 ENOG4105C84 Histidine ammonia-lyase FK537_RS01690 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FK537_RS01705 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FK537_RS01795 ENOG41067CV Integrase FK537_RS01830 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FK537_RS01850 ENOG4108M24 von Willebrand factor, type A FK537_RS01895 ENOG4105DZR Type I site-specific deoxyribonuclease FK537_RS02030 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FK537_RS02055 ENOG4105C3G gtp-binding protein FK537_RS02065 ENOG4108UMN azlc family FK537_RS02070 ENOG4105ZED uncharacterized protein ygaH FK537_RS02080 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FK537_RS02090 ENOG4108V06 Glutathione peroxidase FK537_RS02095 ENOG4105E0X reductase FK537_RS02100 ENOG4105CHM Aminotransferase FK537_RS02105 ENOG4105EXC Acyl-transferase FK537_RS02145 ENOG4105D9P serine threonine protein kinase FK537_RS02190 ENOG4105KTH gatB Yqey FK537_RS02205 ENOG4105ERG peptidase m48, ste24p FK537_RS02210 ENOG4105C5I Dehydrogenase FK537_RS02225 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FK537_RS02270 ENOG4105C1J atp-dependent rna helicase FK537_RS02275 ENOG4105VEQ Cold shock protein FK537_RS02285 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FK537_RS02290 ENOG4105M08 Membrane FK537_RS02305 ENOG4108K3A Glutathione S-transferase FK537_RS02310 ENOG4105CHH sulfate transporter FK537_RS02320 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FK537_RS02340 ENOG4105CEY Amp-dependent synthetase and ligase FK537_RS02345 ENOG4108SGK Tetr family transcriptional regulator FK537_RS02350 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS02355 ENOG4107QX3 carboxylase FK537_RS02360 ENOG4105E39 Enoyl-CoA hydratase FK537_RS02370 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FK537_RS02380 ENOG4107QNJ CoA-transferase subunit B FK537_RS02385 ENOG4105CDV Ompa motb domain protein FK537_RS02390 ENOG4105CD3 dihydroorotase FK537_RS02395 ENOG4105CXT aspartate transcarbamylase FK537_RS02415 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FK537_RS02420 ENOG4108UKZ OsmC family FK537_RS02425 ENOG4107RYR Transcriptional regulator, Crp Fnr family FK537_RS02430 ENOG4105CPC Aldo Keto reductase FK537_RS02445 ENOG4108K0D peptidase, M48 FK537_RS02450 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FK537_RS02465 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FK537_RS02475 ENOG4105CFH Aspartokinase FK537_RS02485 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FK537_RS02495 ENOG4105C3Q Glycosyl transferase, family 2 FK537_RS02500 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase FK537_RS02505 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FK537_RS02510 ENOG4105C7N Xanthine uracil vitamin C permease FK537_RS02530 ENOG4105F8C transglutaminase domain-containing protein FK537_RS02540 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FK537_RS02545 ENOG4105VCD cytoplasmic protein FK537_RS02550 ENOG4105D22 carbon starvation protein FK537_RS02555 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FK537_RS02560 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FK537_RS02580 ENOG4105DHU Bile acid FK537_RS02595 ENOG4105DAN ATP-dependent protease FK537_RS02600 ENOG4105M2J Glutaredoxin FK537_RS02605 ENOG4105C8Y Acetylornithine aminotransferase FK537_RS02610 ENOG4105EJC lysr family transcriptional regulator FK537_RS02615 ENOG4108K5P (LipO)protein FK537_RS02620 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FK537_RS02635 ENOG4105DZ1 carboxypeptidase FK537_RS02640 ENOG4108Z0R Transferase FK537_RS02685 ENOG4107QTF adenylosuccinate lyase FK537_RS02695 ENOG4105ERU peptidase FK537_RS02700 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FK537_RS02710 ENOG4105C8U phosphate abc transporter FK537_RS02720 ENOG4105DY8 decarboxylase FK537_RS02725 ENOG4108JPW Aminotransferase FK537_RS02735 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FK537_RS02745 ENOG4105EQ0 Major Facilitator superfamily FK537_RS02750 ENOG4105KVH Transcriptional regulator FK537_RS02755 ENOG4105ECR NmrA family FK537_RS02775 ENOG4105DTR rard protein FK537_RS02785 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FK537_RS02825 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FK537_RS02830 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FK537_RS02835 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FK537_RS02845 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FK537_RS02850 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FK537_RS02860 ENOG4105C3F Signal peptidase i FK537_RS02875 ENOG4105C0H protease FK537_RS02880 ENOG4108IYU L-aspartate oxidase FK537_RS02885 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FK537_RS02900 ENOG4105HHA aminodeoxychorismate lyase FK537_RS02910 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FK537_RS02920 ENOG4108I5D sulfate abc transporter FK537_RS02930 ENOG4108IJ6 ABC transporter FK537_RS02935 ENOG4107R11 Transcriptional regulator FK537_RS02955 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FK537_RS02960 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FK537_RS02970 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FK537_RS02975 ENOG4108YYC ycei family FK537_RS02985 ENOG4105CGU Enoyl-CoA hydratase FK537_RS03005 ENOG4108ETH Formylglycinamide ribotide synthetase FK537_RS03030 ENOG4106FN3 tellurium resistance protein FK537_RS03060 ENOG4105DAX Pfam:DUF2983 FK537_RS03090 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FK537_RS03100 ENOG4107YD3 Thioesterase FK537_RS03105 ENOG4105E02 MotA TolQ exbB proton channel FK537_RS03110 ENOG4105M8F Biopolymer transport protein exbD tolR FK537_RS03120 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FK537_RS03125 ENOG4105KCK Peptidoglycan-associated lipoprotein FK537_RS03170 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FK537_RS03175 ENOG4105C02 permease FK537_RS03180 ENOG4105CXB phosphoribosylaminoimidazole synthetase FK537_RS03185 ENOG4108V3E phosphoribosylglycinamide formyltransferase FK537_RS03205 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FK537_RS03210 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FK537_RS03215 ENOG4105D60 lipoprotein releasing system transmembrane protein FK537_RS03230 ENOG4108UPT UPF0178 protein FK537_RS03260 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK537_RS03270 ENOG4105C10 Electron transfer flavoprotein FK537_RS03275 ENOG4105BZJ Electron transfer flavoprotein FK537_RS03280 ENOG4105N14 lysine exporter protein LysE YggA FK537_RS03285 ENOG4108YXU transcriptional regulator AsnC family FK537_RS03295 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FK537_RS03310 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FK537_RS03320 ENOG4105C85 amino acid FK537_RS03325 ENOG4105BZG amino acid carrier protein FK537_RS03330 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FK537_RS03340 ENOG4105C0H protease FK537_RS03345 ENOG4107QNR UPF0135 protein FK537_RS03350 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FK537_RS03385 ENOG4108W5M transcriptional regulator FK537_RS03395 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FK537_RS03410 ENOG4105DDQ anthranilate synthase FK537_RS03430 ENOG4105EUJ GTP cyclohydrolase i FK537_RS03440 ENOG4105BZU Histidine kinase FK537_RS03455 ENOG4105NX3 Membrane FK537_RS03460 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FK537_RS03470 ENOG4105C2I pirin domain protein FK537_RS03475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FK537_RS03480 ENOG4107QKW extracellular solute-binding protein family 1 FK537_RS03500 ENOG4108RRZ Transcription elongation factor GreB FK537_RS03505 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FK537_RS03515 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FK537_RS03520 ENOG4105E4C Lytic transglycosylase catalytic FK537_RS03525 ENOG4105D0M Protease HtpX homolog FK537_RS03535 ENOG4105CJW magnesium transporter FK537_RS03540 ENOG4105BZS acriflavin resistance protein FK537_RS03590 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FK537_RS03625 ENOG4105EEI dihydropteroate synthase FK537_RS03635 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FK537_RS03645 ENOG4105HBR Rna-binding protein FK537_RS03660 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FK537_RS03665 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FK537_RS03675 ENOG4108Q5F Tetr family transcriptional regulator FK537_RS03680 ENOG4108UQ8 endoribonuclease L-psp FK537_RS03685 ENOG4105EQK -acetyltransferase FK537_RS03690 ENOG4108YV4 Universal stress protein FK537_RS03700 ENOG4105CGZ zinc metallopeptidase FK537_RS03705 ENOG4105CKW Inner membrane protein yedI FK537_RS03720 ENOG4107S78 Band 7 protein FK537_RS03730 ENOG4105CND Glycosyl transferase, family 2 FK537_RS03735 ENOG4107BJW polysaccharide deacetylase FK537_RS03745 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FK537_RS03755 ENOG4107QN2 dihydrolipoyl dehydrogenase FK537_RS03760 ENOG4105C7S Dehydrogenase FK537_RS03765 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FK537_RS03770 ENOG4105E33 succinate dehydrogenase FK537_RS03780 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FK537_RS03785 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FK537_RS03810 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FK537_RS03825 ENOG4105C4K Nad synthetase FK537_RS03855 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FK537_RS03865 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FK537_RS03875 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FK537_RS03895 ENOG4105C34 Pseudouridine synthase FK537_RS03900 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FK537_RS03905 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FK537_RS03920 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FK537_RS03950 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FK537_RS03990 ENOG4107T5V SNARE associated Golgi FK537_RS04015 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FK537_RS04025 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FK537_RS04040 ENOG4105CUB amino acid FK537_RS04045 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FK537_RS04050 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FK537_RS04055 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FK537_RS04065 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FK537_RS04090 ENOG410841Q phosphoesterase PA-phosphatase related protein FK537_RS04095 ENOG4105C1P efflux transporter, rnd family, mfp subunit FK537_RS04100 ENOG4105BZS acriflavin resistance protein FK537_RS04105 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FK537_RS04110 ENOG4105K8R UPF0145 protein FK537_RS04115 ENOG4105K8R UPF0145 protein FK537_RS04120 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FK537_RS04130 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FK537_RS04140 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FK537_RS04170 ENOG4108RS6 transposase FK537_RS04175 ENOG4105D5G Transposase FK537_RS04185 ENOG4107VMU Membrane FK537_RS04195 ENOG4107RP9 extracellular solute-binding protein, family 3 FK537_RS04200 ENOG4105EAD ABC transporter FK537_RS04205 ENOG4105DRP amino acid AbC transporter FK537_RS04210 ENOG4105CDA abc transporter atp-binding protein FK537_RS04215 ENOG4108UHE carbonic anhydrase FK537_RS04230 ENOG4105D78 K07001 NTE family protein FK537_RS04245 ENOG4105CK7 Sodium proline symporter FK537_RS04250 ENOG4105JJR Histidine kinase FK537_RS04255 ENOG4107EXC regulatoR FK537_RS04260 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FK537_RS04270 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FK537_RS04275 ENOG4109066 lysm domain bon superfamily protein FK537_RS04285 ENOG4105CHR reductase FK537_RS04290 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FK537_RS04300 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FK537_RS04305 ENOG4108BPE -transporting atpase FK537_RS04310 ENOG4107RTD sua5 ycio yrdc ywlc family protein FK537_RS04320 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FK537_RS04325 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FK537_RS04330 ENOG4105FE9 pseudouridine synthase FK537_RS04340 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FK537_RS04345 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FK537_RS04355 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FK537_RS04360 ENOG4108UWD Iron-storage protein FK537_RS04365 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FK537_RS04370 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FK537_RS04375 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FK537_RS04385 ENOG4105HF0 Membrane FK537_RS04405 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FK537_RS04460 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FK537_RS04465 ENOG4105DSF transport protein FK537_RS04475 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FK537_RS04480 ENOG4105K78 MarR family Transcriptional regulator FK537_RS04495 ENOG4105D3G Pseudouridine synthase FK537_RS04525 ENOG4108I0Z Aconitate hydratase FK537_RS04530 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FK537_RS04545 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FK537_RS04560 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FK537_RS04570 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FK537_RS04575 ENOG4108K4C ec 3.1.3.12 FK537_RS04585 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FK537_RS04590 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FK537_RS04595 ENOG4105CI3 gtp-binding protein typa FK537_RS04600 ENOG4105C2W permease FK537_RS04610 ENOG4108IQI permease FK537_RS04630 ENOG4105CHU acetyl-coa acetyltransferase FK537_RS04645 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FK537_RS04655 ENOG4108R6W Transcriptional regulator, ARAC family FK537_RS04660 ENOG4105CHU acetyl-coa acetyltransferase FK537_RS04665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FK537_RS04685 ENOG4108UT2 hemolysin iii FK537_RS04690 ENOG4105CSH Transporter FK537_RS04700 ENOG4105DIN metallophosphoesterase FK537_RS04705 ENOG4107RZC phospholipase d FK537_RS04715 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FK537_RS04745 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FK537_RS04750 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FK537_RS04755 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FK537_RS04765 ENOG4108UJD 30S ribosomal protein S9 FK537_RS04770 ENOG4107MKT Stringent starvation protein a FK537_RS04775 ENOG4105KB2 stringent starvation protein b FK537_RS04840 ENOG4107QHF type ii secretion system protein e FK537_RS04860 ENOG4105C2M dna polymerase I FK537_RS04865 ENOG4108VIA integral membrane protein FK537_RS04870 ENOG4105II7 pyrroline-5-carboxylate reductase FK537_RS04875 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FK537_RS04885 ENOG4105C9X ppx gppa phosphatase FK537_RS04895 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FK537_RS04910 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FK537_RS04945 ENOG4105W39 Membrane FK537_RS04950 ENOG4105CYM Glutathione S-transferase FK537_RS04960 ENOG4105D7V transposase FK537_RS04980 ENOG4105CEY Amp-dependent synthetase and ligase FK537_RS04985 ENOG4105N42 UPF0307 protein FK537_RS04995 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FK537_RS05010 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FK537_RS05015 ENOG4105DJ0 Poly(A) Polymerase FK537_RS05020 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FK537_RS05025 ENOG4105DXN mazG family FK537_RS05040 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FK537_RS05050 ENOG4105CUT histidyl-tRNA synthetase FK537_RS05060 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FK537_RS05080 ENOG4105WVQ Fe-S assembly protein IscX FK537_RS05120 ENOG4108ZP8 Acetolactate synthase small subunit FK537_RS05125 ENOG4105C7K acetolactate synthase FK537_RS05150 ENOG4105DJY efflux transporter, rnd family, mfp subunit FK537_RS05155 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FK537_RS05160 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FK537_RS05220 ENOG4105E5H Transposase FK537_RS05295 ENOG4105CS6 Rhs element vgr protein FK537_RS05300 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FK537_RS05310 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FK537_RS05315 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FK537_RS05325 ENOG4105VW4 glutaredoxin 3 FK537_RS05335 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FK537_RS05345 ENOG4105FFC UPF0187 protein FK537_RS05350 ENOG4105DB7 PHP domain protein FK537_RS05360 ENOG4105K9H YciI-like protein FK537_RS05380 ENOG4108VPT UPF0234 protein FK537_RS05390 ENOG4105NAU thioesterase Superfamily protein FK537_RS05455 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FK537_RS05460 ENOG4105D6S protein involved in catabolism of external DNA FK537_RS05500 ENOG4105E4C Lytic transglycosylase catalytic FK537_RS05510 ENOG4105C9A Phoh family FK537_RS05570 ENOG4105CS1 NAD(P)H quinone oxidoreductase FK537_RS05575 ENOG4107S2Z UPF0761 membrane protein FK537_RS05590 ENOG4105E5H Transposase FK537_RS05620 ENOG4105CIY formyltetrahydrofolate deformylase FK537_RS05625 ENOG41062JF Transcriptional regulator FK537_RS05630 ENOG4107RGH Aldehyde dehydrogenase FK537_RS05645 ENOG4105CKD glutathione-regulated potassium-efflux system protein FK537_RS05665 ENOG4105C4R Atp-dependent dna helicase FK537_RS05675 ENOG4105BZW Glycerate kinase FK537_RS05690 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FK537_RS05710 ENOG4105C5H ABC transporter FK537_RS05715 ENOG4105D1S lipid A biosynthesis FK537_RS05770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FK537_RS05785 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FK537_RS05795 ENOG4105DUM transcriptional regulator, lysR family FK537_RS05800 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FK537_RS05815 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FK537_RS05820 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FK537_RS05835 ENOG4105CSU acyl-Coa dehydrogenase FK537_RS05845 ENOG4105CH6 catalase FK537_RS05860 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FK537_RS05865 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FK537_RS05870 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase FK537_RS05885 ENOG4105FUY alpha subunit FK537_RS05890 ENOG4108W5M transcriptional regulator FK537_RS05905 ENOG4105EPF Outer membrane porin FK537_RS05910 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) FK537_RS05915 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) FK537_RS05920 ENOG4105IKQ hydratase FK537_RS05925 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FK537_RS05930 ENOG4105EI2 Pseudouridine synthase FK537_RS05935 ENOG4105C03 ribonuclease FK537_RS05940 ENOG4105J5T Amp-dependent synthetase and ligase FK537_RS05960 ENOG4108RS6 transposase FK537_RS05975 ENOG41067S9 phage shock protein C, PspC FK537_RS05990 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FK537_RS06015 ENOG4105C5I Dehydrogenase FK537_RS06030 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FK537_RS06040 ENOG4105BZ8 glutamate synthase FK537_RS06050 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FK537_RS06060 ENOG4105C5X domain protein FK537_RS06075 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FK537_RS06085 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FK537_RS06290 ENOG4105CS6 Rhs element vgr protein FK537_RS06295 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FK537_RS06300 ENOG4108JU5 Magnesium and cobalt efflux protein FK537_RS06305 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FK537_RS06315 ENOG4108VAU general secretion pathway protein G FK537_RS06320 ENOG4105D7Q type ii secretion system FK537_RS06325 ENOG4105C25 Primosomal protein n' FK537_RS06335 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FK537_RS06345 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) FK537_RS06350 ENOG4105Z2P Protein of unknown function (DUF465) FK537_RS06365 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FK537_RS06375 ENOG4107QYX exodeoxyribonuclease v alpha FK537_RS06380 ENOG4107QKA exodeoxyribonuclease V beta FK537_RS06385 ENOG4105DSY exodeoxyribonuclease V, gamma FK537_RS06395 ENOG4105CSR polyphosphate kinase 2 FK537_RS06405 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FK537_RS06415 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FK537_RS06425 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FK537_RS06440 ENOG4105D65 subunit l FK537_RS06445 ENOG4108ZE9 Monovalent cation H antiporter subunit C FK537_RS06450 ENOG4107R4Z monovalent cation h antiporter subunit d FK537_RS06455 ENOG4105SC1 monovalent cation H antiporter subunit E FK537_RS06460 ENOG4105W4C monovalent cation H antiporter subunit F FK537_RS06465 ENOG4105KJM monovalent cation h antiporter subunit g FK537_RS06470 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FK537_RS06480 ENOG4105CHV Transcription elongation factor NusA FK537_RS06485 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FK537_RS06510 ENOG4107EJC Preprotein translocase subunit SecG FK537_RS06520 ENOG4107QHF type ii secretion system protein e FK537_RS06535 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FK537_RS06545 ENOG4105C2N RNA methyltransferase TrmH family group 3 FK537_RS06550 ENOG4105NBK UPF0345 protein FK537_RS06555 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FK537_RS06565 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FK537_RS06580 ENOG4105BZ1 (ABC) transporter FK537_RS06585 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FK537_RS06600 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein FK537_RS06615 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FK537_RS06625 ENOG4105C2W permease FK537_RS06635 ENOG4107ZXU DSBA oxidoreductase FK537_RS06665 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FK537_RS06685 ENOG4105D3Y Na H antiporter FK537_RS06705 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FK537_RS06710 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FK537_RS06725 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FK537_RS06735 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FK537_RS06740 ENOG4105PM1 preprotein translocase subunit SecE FK537_RS06780 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FK537_RS06790 ENOG4105GVR general secretion pathway protein D FK537_RS06805 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS FK537_RS06830 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FK537_RS06835 ENOG4108NEV two component transcriptional regulator, LytTR family FK537_RS06840 ENOG4108HRK Histidine kinase FK537_RS06855 ENOG4108UTW Plays a role in the regulation of phosphate uptake FK537_RS06875 ENOG41087AY ADP-Ribose pyrophosphatase FK537_RS06880 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FK537_RS06890 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FK537_RS06900 ENOG4105CNI cell division protein FtsW FK537_RS06915 ENOG4105CE1 Ferrous iron transport protein b FK537_RS06925 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FK537_RS06930 ENOG4105T95 Thiol disulfide interChange protein FK537_RS06935 ENOG4105D6E homoserine dehydrogenase FK537_RS06945 ENOG41061WM D-Alanyl-D-Alanine FK537_RS06955 ENOG4107TUY Histidine kinase FK537_RS06960 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FK537_RS06970 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FK537_RS06975 ENOG4108K5H permease YjgP YjgQ family protein FK537_RS06980 ENOG4108M8S permease YjgP YjgQ family protein FK537_RS07005 ENOG4105DQR SNARE associated Golgi FK537_RS07020 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FK537_RS07030 ENOG4105BZU Histidine kinase FK537_RS07045 ENOG4105C0P Mg chelatase subunit ChlI FK537_RS07055 ENOG41090KI Outer membrane porin FK537_RS07060 ENOG4105F0N pyrophosphate phospho-hydrolase FK537_RS07075 ENOG4105CEY Amp-dependent synthetase and ligase FK537_RS07080 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK537_RS07085 ENOG41079KZ Major Facilitator Superfamily FK537_RS07090 ENOG4105EN6 Membrane FK537_RS07095 ENOG4105K5B UPF0225 protein FK537_RS07100 ENOG4105EE5 Membrane protein terC FK537_RS07105 ENOG4108URH decarboxylase FK537_RS07120 ENOG4105C0R drug resistance transporter emrb qaca subfamily FK537_RS07135 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FK537_RS07150 ENOG4105CCT upf0313 protein FK537_RS07155 ENOG4105D94 Major Facilitator Superfamily FK537_RS07205 ENOG4105C79 DNA protecting protein DprA FK537_RS07220 ENOG4108V06 Glutathione peroxidase FK537_RS07230 ENOG4105EUB pirin domain protein FK537_RS07235 ENOG41090VV Protein of unknown function (DUF2846) FK537_RS07245 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FK537_RS07295 ENOG4105FDK ABC transporter FK537_RS07300 ENOG4105FAV ABC, transporter FK537_RS07305 ENOG410829K Lysine exporter protein (Lyse ygga) FK537_RS07310 ENOG4105EZR dyp-type peroxidase family protein FK537_RS07370 ENOG4105CS6 Rhs element vgr protein FK537_RS07375 ENOG4107R1I NAD-dependent malic enzyme FK537_RS07415 ENOG4106H3A restriction FK537_RS07420 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FK537_RS07425 ENOG4108VBZ doxx family FK537_RS07430 ENOG4105DQR SNARE associated Golgi FK537_RS07445 ENOG4107QJE Chromosome Partitioning Protein FK537_RS07455 ENOG4105M85 Bola protein FK537_RS07490 ENOG4105ZTP Protein of unknown function (DUF1376) FK537_RS07570 ENOG4105KT5 UmuD protein FK537_RS07575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FK537_RS07590 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FK537_RS07665 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FK537_RS07670 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FK537_RS07680 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FK537_RS07685 ENOG4108ZAI phosphatidylglycerophosphatase a FK537_RS07695 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FK537_RS07705 ENOG4105CMR udp-glucose 4-epimerase FK537_RS07715 ENOG4105C6Y Udp-glucose 6-dehydrogenase FK537_RS07720 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FK537_RS07730 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FK537_RS07735 ENOG4107WZ3 Transferase FK537_RS07740 ENOG4105D3Q Sugar transferase FK537_RS07760 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FK537_RS07770 ENOG41090RK glycosyl transferase FK537_RS07775 ENOG4105C6Y Udp-glucose 6-dehydrogenase FK537_RS07810 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FK537_RS07815 ENOG4105C1B dTDP-glucose 4-6-dehydratase FK537_RS07820 ENOG4105DAY polysaccharide export protein FK537_RS07830 ENOG4105D75 Capsular exopolysaccharide family FK537_RS07835 ENOG4108MRJ FK537_RS07870 ENOG4105DJY efflux transporter, rnd family, mfp subunit FK537_RS07875 ENOG4105J7D transcriptional regulator FK537_RS07885 ENOG4105C2W permease FK537_RS07895 ENOG4108RS6 transposase FK537_RS07915 ENOG4105C01 Dihydroxy-acid dehydratase FK537_RS07935 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FK537_RS07945 ENOG4105C8J )-transporter FK537_RS07950 ENOG4105C26 Dehydrogenase FK537_RS07960 ENOG4105D2S major facilitator superfamily FK537_RS07990 ENOG4105CGH 5'-nucleotidase FK537_RS08015 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FK537_RS08020 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FK537_RS08030 ENOG4108821 RND type efflux pump FK537_RS08035 ENOG4108821 RND type efflux pump FK537_RS08040 ENOG4108821 RND type efflux pump FK537_RS08045 ENOG4105C5H ABC transporter FK537_RS08050 ENOG4105E2A Dehydrogenase FK537_RS08055 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK537_RS08065 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FK537_RS08070 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FK537_RS08080 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FK537_RS08085 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FK537_RS08090 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FK537_RS08110 ENOG4108RS6 transposase FK537_RS08125 ENOG4105PGM cation diffusion facilitator family transporter FK537_RS08130 ENOG4105T95 Thiol disulfide interChange protein FK537_RS08140 ENOG4108UGV hypoxanthine phosphoribosyltransferase FK537_RS08150 ENOG4107QUY Guanine deaminase FK537_RS08155 ENOG4105DU1 integral membrane protein, terc FK537_RS08165 ENOG410830R acetyltransferase FK537_RS08175 ENOG4105DFU Cell wall formation (By similarity) FK537_RS08190 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FK537_RS08195 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FK537_RS08205 ENOG4105CVE Lytic murein transglycosylase FK537_RS08250 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FK537_RS08280 ENOG4105D2S major facilitator superfamily FK537_RS08295 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FK537_RS08300 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FK537_RS08305 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FK537_RS08310 ENOG4105DTN riboflavin biosynthesis protein ribF FK537_RS08320 ENOG4108R86 Transcriptional regulator FK537_RS08325 ENOG4105D7V transposase FK537_RS08335 ENOG4108VM9 ABC, transporter FK537_RS08340 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FK537_RS08345 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FK537_RS08350 ENOG4105GVF (ABC) transporter FK537_RS08355 ENOG4105GVF (ABC) transporter FK537_RS08360 ENOG4107QZM n-acetylglutamate synthase FK537_RS08385 ENOG4105UBK short-chain dehydrogenase reductase FK537_RS08390 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FK537_RS08395 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FK537_RS08400 ENOG4108Z33 Thiol disulfide Interchange Protein FK537_RS08405 ENOG4105EJ2 Transcriptional regulator FK537_RS08410 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FK537_RS08415 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FK537_RS08420 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FK537_RS08425 ENOG4105CJR Integral membrane protein (MviN FK537_RS08430 ENOG4108V1T peptidylprolyl cis-trans isomerase FK537_RS08435 ENOG4108V1T peptidylprolyl cis-trans isomerase FK537_RS08440 ENOG4105DQ4 alcohol dehydrogenase FK537_RS08445 ENOG4108R3E Dna-3-methyladenine glycosylase i FK537_RS08455 ENOG4105FAA peptidase M23 FK537_RS08460 ENOG4105CEN a g-specific adenine glycosylase FK537_RS08480 ENOG4108ZZ3 UPF0260 protein FK537_RS08485 ENOG4105D1H recombination factor protein RarA FK537_RS08490 ENOG4105C8V SAICAR synthetase FK537_RS08500 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FK537_RS08505 ENOG4108SC4 )-transporter FK537_RS08510 ENOG4108RWI nicotinamidase FK537_RS08515 ENOG4105C09 Bile acid FK537_RS08530 ENOG4105EAC phosphoserine phosphatase FK537_RS08565 ENOG4105KHC sulfurtransferase FK537_RS08575 ENOG4105BZU Histidine kinase FK537_RS08580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FK537_RS08595 ENOG4108RS6 transposase FK537_RS08605 ENOG4105E2B Taurine dioxygenase FK537_RS08610 ENOG4107QJQ Mate efflux family protein FK537_RS08615 ENOG4105CHM Aminotransferase FK537_RS08620 ENOG4106BRA Membrane FK537_RS08635 ENOG4105D9M gamma-glutamylcysteine synthetase FK537_RS08640 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FK537_RS08650 ENOG4105IPS esterase FK537_RS08655 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK537_RS08660 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FK537_RS08665 ENOG4105C32 Amino acid ABC transporter (Permease) FK537_RS08675 ENOG4105C0Z ABC transporter FK537_RS08680 ENOG4108IV0 ABC, transporter FK537_RS08690 ENOG4105C8P )-transporter FK537_RS08705 ENOG4108Z2U ureidoglycolate hydrolase FK537_RS08710 ENOG4105DHG Allantoate amidinohydrolase FK537_RS08715 ENOG41061H0 Monooxygenase FK537_RS08720 ENOG4108Z7F N-acetyltransferase FK537_RS08760 ENOG4108K3A Glutathione S-transferase FK537_RS08765 ENOG4105BZU Histidine kinase FK537_RS08770 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FK537_RS08785 ENOG4105KUZ arsenate reductase FK537_RS08790 ENOG4105CGK Exodeoxyribonuclease III FK537_RS08835 ENOG4105KRQ Addiction module toxin, Txe YoeB family FK537_RS08845 ENOG4105D7Z glutathione synthase FK537_RS08850 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FK537_RS08855 ENOG4105DFU Cell wall formation (By similarity) FK537_RS08865 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FK537_RS08870 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FK537_RS08875 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FK537_RS08895 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FK537_RS08900 ENOG4107QSN dihydrolipoamide acetyltransferase FK537_RS08920 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FK537_RS08935 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FK537_RS08955 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FK537_RS08960 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FK537_RS08970 ENOG4105D64 Mechanosensitive ion channel FK537_RS08975 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FK537_RS08980 ENOG4107T8P acyl-Coa dehydrogenase FK537_RS08985 ENOG4108UZX fmn reductase FK537_RS09000 ENOG4105BZU Histidine kinase FK537_RS09005 ENOG41062QD Membrane FK537_RS09010 ENOG4107QN1 sodium solute FK537_RS09030 ENOG4105C94 Transporter FK537_RS09040 ENOG4105BZU Histidine kinase FK537_RS09045 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FK537_RS09050 ENOG4105ETU transcriptional activator (TenA FK537_RS09060 ENOG4107RDB Major Facilitator FK537_RS09065 ENOG4108UUM single-stranded DNA-binding protein FK537_RS09070 ENOG4105D3R alkyl hydroperoxide reductase FK537_RS09075 ENOG4105EUB pirin domain protein FK537_RS09080 ENOG4105CVN desaturase FK537_RS09105 ENOG4105DFH Transport of potassium into the cell (By similarity) FK537_RS09145 ENOG4105CUV Homoserine Kinase FK537_RS09160 ENOG4108Q5Y Membrane FK537_RS09185 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FK537_RS09215 ENOG4105CYC Transferase FK537_RS09220 ENOG4105E0F Histidine kinase FK537_RS09240 ENOG4105PDP Short chain dehydrogenase FK537_RS09250 ENOG4105C5H ABC transporter FK537_RS09270 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FK537_RS09280 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FK537_RS09285 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FK537_RS09295 ENOG4105CJN penicillin-binding protein FK537_RS09300 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FK537_RS09305 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FK537_RS09315 ENOG4105DHI Methyltransferase FK537_RS09320 ENOG4108JQC penicillin-binding protein 1A FK537_RS09345 ENOG4105E4G Type IV pilus FK537_RS09365 ENOG4105CBC glutamate synthase FK537_RS09370 ENOG4105BZ8 glutamate synthase FK537_RS09380 ENOG4108V0P LemA family FK537_RS09385 ENOG4105HA9 of methanol dehydrogenase type FK537_RS09405 ENOG4108YSG O-Antigen polymerase FK537_RS09410 ENOG4108UQY Iron-storage protein FK537_RS09415 ENOG4105W53 bacterioferritin-associated ferredoxin FK537_RS09420 ENOG4105KME endoribonuclease L-psp FK537_RS09425 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FK537_RS09430 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FK537_RS09435 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FK537_RS09480 ENOG4105K5M 30s ribosomal protein S16 FK537_RS09485 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FK537_RS09495 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FK537_RS09505 ENOG4107IFA Lipase (EC 3.1.1.3) FK537_RS09510 ENOG4107IFA Lipase (EC 3.1.1.3) FK537_RS09515 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) FK537_RS09520 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FK537_RS09545 ENOG4108JQ1 Dehydrogenase FK537_RS09550 ENOG4105CQB FAD linked oxidase domain protein FK537_RS09560 ENOG4107QF7 multi-drug FK537_RS09565 ENOG4105VCH membrane FK537_RS09570 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FK537_RS09575 ENOG4105IPI Membrane FK537_RS09580 ENOG4107SKI cobyrinic Acid a,c-diamide synthase FK537_RS09595 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FK537_RS09615 ENOG4105WMR Protein CrcB homolog FK537_RS09620 ENOG4105NRA 50s ribosomal protein l31 type b FK537_RS09630 ENOG4107QI1 Mate efflux family protein FK537_RS09640 ENOG4105CSA Coproporphyrinogen iii oxidase FK537_RS09645 ENOG4105CSU acyl-Coa dehydrogenase FK537_RS09660 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FK537_RS09665 ENOG4105D4P Coproporphyrinogen iii oxidase FK537_RS09680 ENOG4105ECY inositol monophosphatase FK537_RS09685 ENOG4105C1J atp-dependent rna helicase FK537_RS09690 ENOG4105DHJ ABC, transporter FK537_RS09695 ENOG4105CY3 ABC transporter, permease FK537_RS09700 ENOG4107PE3 Mammalian cell entry related domain protein FK537_RS09705 ENOG4105E3I toluene tolerance FK537_RS09715 ENOG4107QUT magnesium and cobalt transport protein CorA FK537_RS09720 ENOG4108URH decarboxylase FK537_RS09730 ENOG4105MJ2 Competence protein FK537_RS09735 ENOG4105CB5 ATP-dependent DNA helicase recG FK537_RS09745 ENOG4105E55 glycerol-3-phosphate acyltransferase FK537_RS09750 ENOG4105C29 acyl-CoA thioesterase FK537_RS09755 ENOG4105CK2 sodium dicarboxylate symporter FK537_RS09775 ENOG4105D7V transposase FK537_RS09795 ENOG4105D7A ATP-binding protein FK537_RS09810 ENOG41089BK Glutamine amido-transferase FK537_RS09825 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FK537_RS09855 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FK537_RS09890 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FK537_RS09895 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FK537_RS09905 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FK537_RS09920 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FK537_RS09940 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FK537_RS09945 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FK537_RS09955 ENOG4105CT3 Monooxygenase FK537_RS09960 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS09990 ENOG4105EMK carboxylate amino acid amine transporter FK537_RS10000 ENOG4105VKU nucleicacid-binding protein FK537_RS10005 ENOG4105DGW oligopeptidase A FK537_RS10010 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FK537_RS10045 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FK537_RS10075 ENOG4105QNF Outer membrane lipoprotein FK537_RS10135 ENOG4105DWV Homoserine O-trans-acetylase FK537_RS10140 ENOG4105DWV Homoserine O-trans-acetylase FK537_RS10145 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FK537_RS10155 ENOG4107E2E PKHD-type hydroxylase FK537_RS10160 ENOG4108IU3 tonb-dependent siderophore receptor FK537_RS10165 ENOG4105D05 Receptor FK537_RS10175 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FK537_RS10205 ENOG4107GFK fumarate FK537_RS10230 ENOG4108DNC Involved in acetate metabolism (By similarity) FK537_RS10235 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FK537_RS10265 ENOG4105CN1 protease FK537_RS10270 ENOG4105BZU Histidine kinase FK537_RS10310 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FK537_RS10325 ENOG4105F8V Hydrolase, tatD family FK537_RS10330 ENOG4105CUZ uba thif-type nad fad binding protein FK537_RS10335 ENOG4105VNT transposase (IS4 family) protein FK537_RS10340 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FK537_RS10360 ENOG4105CEV competence damage-inducible protein FK537_RS10385 ENOG4106UX7 integral membrane protein FK537_RS10390 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FK537_RS10395 ENOG4105W8H transhydrogenase (subunit alpha FK537_RS10400 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FK537_RS10410 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FK537_RS10420 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase FK537_RS10425 ENOG4105BZU Histidine kinase FK537_RS10430 ENOG4105C6T cysteine synthase FK537_RS10445 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FK537_RS10455 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FK537_RS10460 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FK537_RS10465 ENOG4105VIE preprotein translocase, subunit YajC FK537_RS10480 ENOG4108V0P LemA family FK537_RS10490 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FK537_RS10500 ENOG4105E9K Isocitrate dehydrogenase FK537_RS10505 ENOG4105VNT transposase (IS4 family) protein FK537_RS10510 ENOG4105BZU Histidine kinase FK537_RS10515 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FK537_RS10520 ENOG4105CM2 brancheD-chain amino acid aminotransferase FK537_RS10525 ENOG4105C6Y Udp-glucose 6-dehydrogenase FK537_RS10545 ENOG4107XU6 Glycosyl transferase (Group 1 FK537_RS10570 ENOG4105C9M aspartyl-trna synthetase FK537_RS10580 ENOG4105UGU tonB-dependent Receptor FK537_RS10600 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FK537_RS10620 ENOG4105VNT transposase (IS4 family) protein FK537_RS10630 ENOG4105CSU acyl-Coa dehydrogenase FK537_RS10635 ENOG4105CSU acyl-Coa dehydrogenase FK537_RS10645 ENOG4105EB3 Histidine kinase FK537_RS10650 ENOG4105E3W Two component transcriptional regulator (Winged helix family FK537_RS10660 ENOG4105MSB protein, conserved in bacteria FK537_RS10670 ENOG4105VNT transposase (IS4 family) protein FK537_RS10690 ENOG4108WBT adenosyltransferase FK537_RS10695 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FK537_RS10740 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FK537_RS10745 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FK537_RS10760 ENOG4105D3R alkyl hydroperoxide reductase FK537_RS10775 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FK537_RS10780 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FK537_RS10810 ENOG4108KHX Diguanylate cyclase FK537_RS10870 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FK537_RS10875 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FK537_RS10925 ENOG4105P8F nudix hydrolase FK537_RS10930 ENOG4108Z0R Transferase FK537_RS10935 ENOG41072GX Peptidase M22 Glycoprotease FK537_RS10940 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FK537_RS10960 ENOG4108M3P Membrane FK537_RS10975 ENOG4105DJV ribulose-phosphate 3-epimerase FK537_RS10985 ENOG4105E3B Multicopper oxidase FK537_RS10995 ENOG4105KPY Small multidrug resistance protein FK537_RS11000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FK537_RS11015 ENOG4105DWF phosphomethylpyrimidine kinase FK537_RS11020 ENOG4107XGZ Hydrolase FK537_RS11025 ENOG4105EW9 transcriptional regulator AsnC family FK537_RS11040 ENOG4105M4H endoribonuclease L-psp FK537_RS11050 ENOG4108YXA Membrane FK537_RS11065 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FK537_RS11090 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FK537_RS11100 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FK537_RS11105 ENOG4105C3M thioredoxin reductase FK537_RS11110 ENOG4105CNU cell division protein FtsK FK537_RS11125 ENOG4107QMS site-determining protein FK537_RS11130 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FK537_RS11140 ENOG4106HNH Acyl-transferase FK537_RS11145 ENOG4108ZG0 Ompa motb domain protein FK537_RS11150 ENOG4105C4R Atp-dependent dna helicase FK537_RS11160 ENOG4107QKV phosphomannomutase FK537_RS11175 ENOG4105E7A Glutamine amidotransferase FK537_RS11190 ENOG4105VDB UPF0125 protein FK537_RS11200 ENOG41090R7 Ferric uptake FK537_RS11205 ENOG4105CZX twitching motility protein FK537_RS11210 ENOG4105CZX twitching motility protein FK537_RS11215 ENOG4105DFA alanine racemase domain protein FK537_RS11225 ENOG4105EYH Exonuclease FK537_RS11230 ENOG4107RH8 nuclease SbcCD subunit D FK537_RS11240 ENOG4105MWK D-amino acid dehydrogenase, small subunit FK537_RS11245 ENOG4105D52 delta-aminolevulinic acid dehydratase FK537_RS11250 ENOG4108VUY thioesterase Superfamily protein FK537_RS11255 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FK537_RS11265 ENOG4105DFP Integrase FK537_RS11390 ENOG4107R3N Filamentation induced by cAMP protein fic FK537_RS11445 ENOG4107BJW polysaccharide deacetylase FK537_RS11450 ENOG4105CND Glycosyl transferase, family 2 FK537_RS11495 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FK537_RS11505 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FK537_RS11515 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FK537_RS11520 ENOG4105VQ7 Rod shape-determining protein MreD FK537_RS11525 ENOG4108Z03 MAF-like protein FK537_RS11530 ENOG4105C03 ribonuclease FK537_RS11540 ENOG4105D8T Acyltransferase FK537_RS11550 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein FK537_RS11580 ENOG4108RXX maleylacetoacetate isomerase FK537_RS11605 ENOG4105C85 amino acid FK537_RS11610 ENOG4105C7F AcnD-accessory protein PrpF FK537_RS11615 ENOG4105CTB Polyprenyl synthetase FK537_RS11625 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FK537_RS11640 ENOG4105GKE subunit e FK537_RS11645 ENOG4107QIZ NADH dehydrogenase FK537_RS11650 ENOG4108IEH NADH dehydrogenase subunit g FK537_RS11655 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FK537_RS11660 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FK537_RS11665 ENOG4107UFS subunit j FK537_RS11670 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FK537_RS11675 ENOG4105D65 subunit l FK537_RS11680 ENOG4105C8S subunit m FK537_RS11695 ENOG4105VEQ Cold shock protein FK537_RS11705 ENOG4105DUM transcriptional regulator, lysR family FK537_RS11710 ENOG4105DP0 ferredoxin-NADP reductase FK537_RS11745 ENOG4105CBX hi0933 family FK537_RS11760 ENOG4105K6H D-cysteine desulfhydrase FK537_RS11790 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FK537_RS11795 ENOG4105D1F ATP-binding protein FK537_RS11810 ENOG4105H1G trap transporter solute receptor taxi family FK537_RS11845 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FK537_RS11865 ENOG4108UNF response regulator FK537_RS11870 ENOG4105M3Z response regulator FK537_RS11875 ENOG4108ZGA chew protein FK537_RS11880 ENOG4105C8Q Methyl-accepting chemotaxis FK537_RS11900 ENOG4106BSU Entericidin B FK537_RS11910 ENOG4105WD1 Membrane FK537_RS11915 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein FK537_RS11970 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FK537_RS11980 ENOG4105EM2 membrane FK537_RS11985 ENOG4105C2C drug resistance transporter, Bcr CflA FK537_RS12000 ENOG4105D6U Sodium Glutamate Symporter FK537_RS12005 ENOG4105BZG amino acid carrier protein FK537_RS12010 ENOG4105FGV Chromate FK537_RS12015 ENOG4105D78 K07001 NTE family protein FK537_RS12025 ENOG4108S4H thioesterase Superfamily protein FK537_RS12035 ENOG4105CZM Major Facilitator FK537_RS12040 ENOG4108W5M transcriptional regulator FK537_RS12060 ENOG4105CKI cobalamin synthesis protein FK537_RS12065 ENOG4108VWS Yaeq family FK537_RS12075 ENOG4105BZU Histidine kinase FK537_RS12105 ENOG4105CSH Transporter FK537_RS12115 ENOG4105CSV Glutaminase FK537_RS12120 ENOG4105CMT Dihydroxyacetone kinase FK537_RS12140 ENOG4105C3R Methionine synthase FK537_RS12145 ENOG4105CJ3 phosphate transporter FK537_RS12170 ENOG4105D05 Receptor FK537_RS12190 ENOG4108UJV acyl-CoA thioesterase i FK537_RS12195 ENOG4108I0Y (ABC) transporter FK537_RS12200 ENOG4105CV6 ABC transporter, permease FK537_RS12205 ENOG4107U91 Rhomboid family FK537_RS12210 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FK537_RS12220 ENOG4105C5Q Transcriptional regulator FK537_RS12230 ENOG4107QZF nitrite reductase NADPH large subunit FK537_RS12235 ENOG4105VCQ rubredoxin FK537_RS12240 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FK537_RS12265 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FK537_RS12300 ENOG4105C37 (CBS) domain FK537_RS12310 ENOG4107RET Isocitrate lyase FK537_RS12320 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FK537_RS12325 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FK537_RS12335 ENOG4105CHR reductase FK537_RS12355 ENOG4105CQM Urea amidohydrolase subunit alpha FK537_RS12370 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FK537_RS12375 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FK537_RS12385 ENOG4106H78 methyltransferase FK537_RS12390 ENOG4105CJN penicillin-binding protein FK537_RS12415 ENOG4105CSM endonuclease III FK537_RS12420 ENOG4108R3D Electron transport complex FK537_RS12425 ENOG4105D82 Glutamate dehydrogenase FK537_RS12435 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FK537_RS12445 ENOG4107VAM peptidase, m28 FK537_RS12455 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FK537_RS12470 ENOG4105DAA L-lactate FK537_RS12475 ENOG41073TP transcriptional regulator FK537_RS12485 ENOG4105CXG d-lactate dehydrogenase FK537_RS12515 ENOG4105E07 UPF0149 protein FK537_RS12520 ENOG4107RAQ aminopeptidase FK537_RS12525 ENOG4105D0A hydroxylase FK537_RS12530 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FK537_RS12540 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FK537_RS12545 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FK537_RS12555 ENOG4105W4M Transport-associated protein FK537_RS12560 ENOG4105EBR Carboxylesterase FK537_RS12565 ENOG4105E09 nadh pyrophosphatase FK537_RS12575 ENOG4107RZZ dna polymerase iii epsilon subunit FK537_RS12580 ENOG4105E9H Lytic Murein transglycosylase FK537_RS12585 ENOG4105E43 Extracellular solute-binding protein, family 5 FK537_RS12590 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FK537_RS12595 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FK537_RS12600 ENOG4108JQ5 ABC transporter FK537_RS12630 ENOG4108IQI permease FK537_RS12655 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FK537_RS12660 ENOG4105EKE dihydroorotase FK537_RS12680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FK537_RS12700 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein FK537_RS12730 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FK537_RS12740 ENOG4105C6K Malic enzyme FK537_RS12745 ENOG4105BZU Histidine kinase FK537_RS12750 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FK537_RS12755 ENOG4105SYT Methylenetetrahydrofolate reductase FK537_RS12760 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FK537_RS12795 ENOG4107QPN acyl-Coa dehydrogenase FK537_RS12800 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FK537_RS12825 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FK537_RS12830 ENOG4105CE9 30S ribosomal protein S2 FK537_RS12855 ENOG4105CVE Lytic murein transglycosylase FK537_RS12870 ENOG4105E3A (ABC) transporter FK537_RS12875 ENOG4105DA5 (ABC) transporter FK537_RS12930 ENOG4105NXH GreA GreB family elongation factor FK537_RS12950 ENOG4108JU3 Alkyl hydroperoxide reductase FK537_RS12955 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FK537_RS12960 ENOG4105CFP Peptidase U32 FK537_RS12970 ENOG41082YX Transcriptional regulator, arsr family FK537_RS12980 ENOG4105D6J arsenicaL-resistance protein FK537_RS12985 ENOG4105CAU Arsenical resistance protein, ArsH FK537_RS13000 ENOG4105DP0 ferredoxin-NADP reductase FK537_RS13005 ENOG4108R96 Methyltransferase, YaeB family FK537_RS13015 ENOG4107QHF type ii secretion system protein e FK537_RS13025 ENOG4105XJC Two component transcriptional regulator (Winged helix family FK537_RS13030 ENOG4105DHQ Histidine kinase FK537_RS13050 ENOG4105BZ4 penicillin-binding protein FK537_RS13055 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FK537_RS13060 ENOG4105VUT cytoplasmic protein FK537_RS13070 ENOG4105CK2 sodium dicarboxylate symporter FK537_RS13075 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS13080 ENOG4107R7Y intracellular protease Pfpi family FK537_RS13085 ENOG4105CQC Prephenate dehydratase FK537_RS13090 ENOG4105CIH Imidazole acetol-phosphate transaminase FK537_RS13095 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FK537_RS13120 ENOG4108YZY peptidylprolyl cis-trans isomerase FK537_RS13125 ENOG4105CEP NADH dehydrogenase FK537_RS13130 ENOG4105DZ1 carboxypeptidase FK537_RS13145 ENOG4108R99 pseudouridine synthase FK537_RS13160 ENOG4105FAA peptidase M23 FK537_RS13185 ENOG4108MEJ flavin reductase domain protein FK537_RS13190 ENOG4105JAB phenazine biosynthesis protein, phzf family FK537_RS13230 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FK537_RS13255 ENOG4105D3G Pseudouridine synthase FK537_RS13260 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FK537_RS13270 ENOG4107R6F Alpha Beta Hydrolase Fold protein FK537_RS13275 ENOG4105EJ2 Transcriptional regulator FK537_RS13410 ENOG4105EQK -acetyltransferase FK537_RS13430 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FK537_RS13450 ENOG4107QS8 (LipO)protein FK537_RS13465 ENOG4105VEQ Cold shock protein FK537_RS13470 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FK537_RS13480 ENOG4105EA8 2-Nitropropane dioxygenase FK537_RS13505 ENOG41066VF YeeE YedE family protein FK537_RS13515 ENOG4108JU3 Alkyl hydroperoxide reductase FK537_RS13540 ENOG4105D3R alkyl hydroperoxide reductase FK537_RS13545 ENOG4105CQ7 ATP-dependent helicase FK537_RS13570 ENOG4105C2X Arabinose 5-phosphate isomerase FK537_RS13585 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FK537_RS13590 ENOG4108IUZ ABC transporter FK537_RS13595 ENOG4105DFG type I secretion outer membrane protein FK537_RS13600 ENOG4108JJA ABC, transporter FK537_RS13605 ENOG4107QZV Type I secretion membrane fusion protein FK537_RS13635 ENOG4108Z4U Ferredoxin FK537_RS13650 ENOG4107RQ0 Maleylacetate reductase FK537_RS13675 ENOG4105C0B DNA polymerase III (alpha subunit) FK537_RS13680 ENOG4108UMI ABC transporter, permease FK537_RS13685 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FK537_RS13690 ENOG4105D01 (LipO)protein FK537_RS13700 ENOG4105C12 Phosphoribosylglycinamide synthetase FK537_RS13705 ENOG4105DC1 bifunctional purine biosynthesis protein purh FK537_RS13710 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FK537_RS13780 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FK537_RS13785 ENOG4105CDU Replicative dna helicase FK537_RS13795 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FK537_RS13810 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FK537_RS13815 ENOG4105CCU oxidase (Subunit III) FK537_RS13820 ENOG4105BZ9 Cytochrome C oxidase, subunit I FK537_RS13825 ENOG4105E2S oxidase) subunit II FK537_RS13850 ENOG4105DEN Luciferase family FK537_RS13865 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FK537_RS13870 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FK537_RS13875 ENOG4105FFC UPF0187 protein FK537_RS13895 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS13910 ENOG4105D06 uba thif-type nad fad binding protein FK537_RS13920 ENOG4105KRF dihydroneopterin aldolase FK537_RS13940 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FK537_RS13965 ENOG4107QIJ Aconitate hydratase 2 FK537_RS13980 ENOG4105D6U Sodium Glutamate Symporter FK537_RS14010 ENOG4105CD8 aminopeptidase N FK537_RS14025 ENOG41081QV Universal stress protein FK537_RS14035 ENOG4105DKK Benzoate FK537_RS14040 ENOG4108NIW Leucine export protein LeuE FK537_RS14045 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FK537_RS14050 ENOG4105EVZ LysR family transcriptional regulator FK537_RS14060 ENOG4105CHU acetyl-coa acetyltransferase FK537_RS14065 ENOG4105CHR reductase FK537_RS14085 ENOG4107QMP dna polymerase iii subunits gamma and tau FK537_RS14095 ENOG4105C0A alcohol dehydrogenase FK537_RS14100 ENOG4105KJF protein tyrosine phosphatase FK537_RS14120 ENOG4105CBC glutamate synthase FK537_RS14130 ENOG4105BZU Histidine kinase FK537_RS14135 ENOG4105EZE Cupin 4 family protein FK537_RS14140 ENOG4108UHJ MAF-like protein FK537_RS14160 ENOG4105D2N Aldolase FK537_RS14165 ENOG4108TZV Membrane FK537_RS14175 ENOG4108RCM Nitroreductase FK537_RS14180 ENOG4105CNV Aldolase FK537_RS14205 ENOG4108T58 Mg2 transport protein CorA FK537_RS14225 ENOG4105C26 Dehydrogenase FK537_RS14230 ENOG4105EW9 transcriptional regulator AsnC family FK537_RS14235 ENOG4105CK7 Sodium proline symporter FK537_RS14240 ENOG4108IJ0 Aspartate ammonia-lyase FK537_RS14245 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FK537_RS14250 ENOG4105W8I Transcriptional regulator FK537_RS14255 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS14275 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FK537_RS14290 ENOG4105VNT transposase (IS4 family) protein FK537_RS14295 ENOG4105F27 Major Facilitator FK537_RS14300 ENOG4105CV8 reductase FK537_RS14305 ENOG4105HEI LysR family (Transcriptional regulator FK537_RS14325 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FK537_RS14330 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FK537_RS14340 ENOG4105CNI cell division protein FtsW FK537_RS14355 ENOG4105Y3E Modulates RecA activity (By similarity) FK537_RS14365 ENOG4105VEJ Heat shock protein FK537_RS14370 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FK537_RS14375 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FK537_RS14390 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FK537_RS14395 ENOG4105K4T epimerase FK537_RS14400 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FK537_RS14415 ENOG4108JA2 transcriptioN-repair coupling factor FK537_RS14425 ENOG4105F8J Adenylate Guanylate cyclase FK537_RS14430 ENOG4108ZIT Ferredoxin, 2FE-2S FK537_RS14445 ENOG4108Z4V iron-sulfur cluster assembly FK537_RS14450 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FK537_RS14460 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FK537_RS14475 ENOG4105K70 DNA-binding protein FK537_RS14480 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FK537_RS14505 ENOG4105K59 histidine triad (HIT) protein FK537_RS14525 ENOG4105C28 cystathionine FK537_RS14535 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FK537_RS14565 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FK537_RS14570 ENOG4105VNT transposase (IS4 family) protein FK537_RS14610 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FK537_RS14655 ENOG4107RKG DJ-1/PfpI family FK537_RS14670 ENOG4108Z66 YbaK ebsC protein FK537_RS14675 ENOG41067MG lrgb family FK537_RS14685 ENOG4105CMU LysR family (Transcriptional regulator FK537_RS14710 ENOG4105CMR udp-glucose 4-epimerase FK537_RS14740 ENOG4105CSU acyl-Coa dehydrogenase FK537_RS14745 ENOG4106AXJ AraC family transcriptional regulator FK537_RS14750 ENOG4105CZM Major Facilitator FK537_RS14755 ENOG41065XD Transcriptional regulator FK537_RS14760 ENOG4105C4M (Ubiquinol oxidase) subunit I FK537_RS14765 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FK537_RS14775 ENOG4105KK6 nuclease FK537_RS14785 ENOG4105C1G acyl-Coa dehydrogenase FK537_RS14825 ENOG4107RZC phospholipase d FK537_RS14835 ENOG4105BZU Histidine kinase FK537_RS14840 ENOG4105CGF Aromatic amino acid aminotransferase FK537_RS14845 ENOG4105C85 amino acid FK537_RS14855 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FK537_RS14860 ENOG4105CZX twitching motility protein FK537_RS14865 ENOG4105CZM Major Facilitator FK537_RS14875 ENOG4108ZX5 transcriptional regulator FK537_RS14885 ENOG4105BZ1 (ABC) transporter FK537_RS14900 ENOG4105CUY Mechanosensitive ion channel FK537_RS14905 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FK537_RS14925 ENOG41080HT Transcriptional regulator, arsr family FK537_RS14930 ENOG4105E55 glycerol-3-phosphate acyltransferase FK537_RS14935 ENOG4105C6T cysteine synthase FK537_RS14950 ENOG4107RNU major facilitator superfamily MFS_1 FK537_RS14955 ENOG4107QZF nitrite reductase NADPH large subunit FK537_RS14960 ENOG4108IFG nitrite reductase, (NAD(P)H) FK537_RS14990 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FK537_RS14995 ENOG4105CVM Molybdenum cofactor synthesis domain protein FK537_RS15005 ENOG4105E0C molybdate abc transporter FK537_RS15010 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FK537_RS15015 ENOG4105DDW LysR family Transcriptional regulator FK537_RS15035 ENOG4105F2Z 3-oxoadipate enol-lactonase FK537_RS15040 ENOG4105CHU acetyl-coa acetyltransferase FK537_RS15045 ENOG4107QNJ CoA-transferase subunit B FK537_RS15050 ENOG4107QP7 CoA-transferase subunit A FK537_RS15055 ENOG4105DKK Benzoate FK537_RS15060 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase FK537_RS15065 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein FK537_RS15070 ENOG4108UKV benzoate 1,2-dioxygenase FK537_RS15075 ENOG4105FUY alpha subunit FK537_RS15085 ENOG4105NN7 muconolactone delta-isomerase FK537_RS15090 ENOG4105DTQ mandelate racemase muconate lactonizing FK537_RS15095 ENOG4108KB2 LysR family Transcriptional regulator FK537_RS15100 ENOG4105D2S major facilitator superfamily FK537_RS15140 ENOG4106UW1 Major Facilitator superfamily FK537_RS15150 ENOG4105D7V transposase FK537_RS15155 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FK537_RS15160 ENOG4105TMB Formate nitrite transporter FK537_RS15180 ENOG4107KET secretion protein, HlyD family FK537_RS15215 ENOG4105C94 Transporter FK537_RS15220 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FK537_RS15225 ENOG4105C26 Dehydrogenase FK537_RS15240 ENOG4105DHQ Histidine kinase FK537_RS15250 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FK537_RS15255 ENOG4107QX9 Thiol disulfide interChange protein FK537_RS15260 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FK537_RS15275 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 FK537_RS15290 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FK537_RS15295 ENOG4105HF0 Membrane FK537_RS15315 ENOG4107Z3H Transcriptional regulator, TetR family FK537_RS15335 ENOG4105CS6 Rhs element vgr protein