locus-tag	class	description
FK537_RS00090	COG2801	Transposase and inactivated derivatives
FK537_RS00095	COG0154	amidase activity
FK537_RS00100	COG2801	Transposase and inactivated derivatives
FK537_RS00150	COG3451	type IV secretory pathway VirB4
FK537_RS00170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FK537_RS00220	COG1192	Involved in chromosome partitioning
FK537_RS00250	COG4974	Belongs to the 'phage' integrase family
FK537_RS00285	COG3421	Type III restriction
FK537_RS00290	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FK537_RS00415	COG2801	Transposase and inactivated derivatives
FK537_RS00505	COG0596	Alpha beta hydrolase
FK537_RS00540	COG0511	ligase activity, forming carbon-carbon bonds
FK537_RS00560	COG2814	Major facilitator Superfamily
FK537_RS00600	COG1546	Belongs to the CinA family
FK537_RS00600	COG1058	Belongs to the CinA family
FK537_RS00610	COG0372	Belongs to the citrate synthase family
FK537_RS00630	COG0477	Major facilitator Superfamily
FK537_RS00645	COG0542	response to heat
FK537_RS00650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FK537_RS00670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FK537_RS00680	COG0569	domain protein
FK537_RS00685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FK537_RS00705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK537_RS00715	COG1585	Membrane protein implicated in regulation of membrane protease activity
FK537_RS00730	COG1294	oxidase, subunit
FK537_RS00735	COG4890	Cyd operon protein YbgT
FK537_RS00770	COG1960	acyl-CoA dehydrogenase activity
FK537_RS00775	COG1960	acyl-CoA dehydrogenase activity
FK537_RS00785	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK537_RS00790	COG2207	Transcriptional regulator
FK537_RS00795	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK537_RS00800	COG0730	response to heat
FK537_RS00805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK537_RS00835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK537_RS00870	COG0575	Belongs to the CDS family
FK537_RS00875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FK537_RS00880	COG0233	cytoplasmic translational termination
FK537_RS00895	COG3852	Histidine kinase
FK537_RS00900	COG2204	response regulator
FK537_RS00910	COG0583	DNA-binding transcription factor activity
FK537_RS00940	COG3385	transposase activity
FK537_RS00945	COG1253	flavin adenine dinucleotide binding
FK537_RS00965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FK537_RS00970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FK537_RS00985	COG2431	L-lysine efflux transmembrane transporter activity
FK537_RS00990	COG0284	orotidine-5'-phosphate decarboxylase activity
FK537_RS01000	COG0776	regulation of translation
FK537_RS01030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FK537_RS01065	COG0084	hydrolase, TatD family'
FK537_RS01085	COG1663	tetraacyldisaccharide 4'-kinase activity
FK537_RS01090	COG1132	(ABC) transporter
FK537_RS01100	COG0811	peptide transport
FK537_RS01105	COG1475	DNA binding
FK537_RS01110	COG1192	Involved in chromosome partitioning
FK537_RS01120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FK537_RS01125	COG3178	'Phosphotransferase
FK537_RS01135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK537_RS01140	COG1923	regulation of RNA biosynthetic process
FK537_RS01150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FK537_RS01155	COG0802	atpase or kinase
FK537_RS01180	COG2707	UPF0756 membrane protein
FK537_RS01190	COG0583	DNA-binding transcription factor activity
FK537_RS01195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK537_RS01225	COG0519	Catalyzes the synthesis of GMP from XMP
FK537_RS01225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK537_RS01230	COG2353	YceI-like domain
FK537_RS01240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FK537_RS01245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FK537_RS01285	COG1254	Belongs to the acylphosphatase family
FK537_RS01290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FK537_RS01290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FK537_RS01295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FK537_RS01315	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_RS01325	COG3327	negative regulation of DNA-templated transcription, initiation
FK537_RS01330	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FK537_RS01335	COG0183	Belongs to the thiolase family
FK537_RS01340	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK537_RS01345	COG1024	Enoyl-CoA hydratase
FK537_RS01350	COG1024	Enoyl-CoA hydratase
FK537_RS01355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK537_RS01360	COG2151	metal-sulfur cluster biosynthetic enzyme
FK537_RS01365	COG3396	Phenylacetate-CoA oxygenase
FK537_RS01370	COG3460	Phenylacetate-CoA oxygenase
FK537_RS01375	COG3396	Phenylacetate-CoA oxygenase
FK537_RS01380	COG2030	dehydratase
FK537_RS01380	COG1012	belongs to the aldehyde dehydrogenase family
FK537_RS01385	COG2814	Major facilitator Superfamily
FK537_RS01390	COG0783	Belongs to the Dps family
FK537_RS01405	COG5002	protein histidine kinase activity
FK537_RS01405	COG5001	Diguanylate cyclase
FK537_RS01415	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
FK537_RS01435	COG4773	Receptor
FK537_RS01470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FK537_RS01505	COG0642	Histidine kinase
FK537_RS01520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FK537_RS01545	COG2816	NAD+ diphosphatase activity
FK537_RS01550	COG3046	protein related to deoxyribodipyrimidine photolyase
FK537_RS01565	COG2351	hydroxyisourate hydrolase activity
FK537_RS01600	COG1136	(ABC) transporter
FK537_RS01610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_RS01630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK537_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_RS01675	COG2986	histidine ammonia-lyase
FK537_RS01690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK537_RS01700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK537_RS01705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK537_RS01795	COG0582	viral genome integration into host DNA
FK537_RS01830	COG1136	(ABC) transporter
FK537_RS01850	COG4245	von Willebrand factor, type A
FK537_RS01895	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FK537_RS02030	COG0204	Acyl-transferase
FK537_RS02055	COG0012	GTP binding
FK537_RS02065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FK537_RS02080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FK537_RS02090	COG0386	Belongs to the glutathione peroxidase family
FK537_RS02095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK537_RS02100	COG0436	Aminotransferase
FK537_RS02105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FK537_RS02105	COG2755	lipolytic protein G-D-S-L family
FK537_RS02145	COG2815	serine threonine protein kinase
FK537_RS02145	COG0515	serine threonine protein kinase
FK537_RS02190	COG1610	YqeY-like protein
FK537_RS02205	COG4783	chaperone-mediated protein folding
FK537_RS02270	COG0513	Belongs to the DEAD box helicase family
FK537_RS02290	COG2363	Small membrane protein
FK537_RS02310	COG0659	secondary active sulfate transmembrane transporter activity
FK537_RS02320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FK537_RS02340	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_RS02345	COG1309	transcriptional regulator
FK537_RS02350	COG1960	acyl-CoA dehydrogenase activity
FK537_RS02355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FK537_RS02360	COG1024	Enoyl-CoA hydratase
FK537_RS02365	COG4770	biotin carboxylase activity
FK537_RS02380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FK537_RS02395	COG0540	Belongs to the ATCase OTCase family
FK537_RS02420	COG1765	OsmC-like protein
FK537_RS02430	COG0667	Aldo Keto reductase
FK537_RS02445	COG0501	Belongs to the peptidase M48B family
FK537_RS02450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FK537_RS02465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FK537_RS02475	COG0527	aspartate kinase activity
FK537_RS02485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FK537_RS02495	COG1215	transferase activity, transferring glycosyl groups
FK537_RS02505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FK537_RS02510	COG2252	PERMEase
FK537_RS02540	COG0714	Associated with various cellular activities
FK537_RS02545	COG2879	small protein
FK537_RS02550	COG1966	Carbon starvation protein
FK537_RS02555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FK537_RS02560	COG1509	lysine 2,3-aminomutase activity
FK537_RS02595	COG1067	ATP-dependent peptidase activity
FK537_RS02600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FK537_RS02605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK537_RS02610	COG0583	DNA-binding transcription factor activity
FK537_RS02620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FK537_RS02635	COG1686	Belongs to the peptidase S11 family
FK537_RS02640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK537_RS02695	COG0616	signal peptide processing
FK537_RS02700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FK537_RS02710	COG0573	inorganic phosphate transmembrane transporter activity
FK537_RS02720	COG0076	glutamate decarboxylase activity
FK537_RS02725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FK537_RS02735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FK537_RS02745	COG2814	Major facilitator Superfamily
FK537_RS02750	COG1733	regulation of RNA biosynthetic process
FK537_RS02755	COG0702	epimerase
FK537_RS02785	COG0556	nucleotide-excision repair
FK537_RS02805	COG0436	Aminotransferase
FK537_RS02830	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FK537_RS02835	COG1381	Involved in DNA repair and RecF pathway recombination
FK537_RS02845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FK537_RS02850	COG0571	ribonuclease III activity
FK537_RS02860	COG0681	Belongs to the peptidase S26 family
FK537_RS02875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FK537_RS02885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK537_RS02900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FK537_RS02910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FK537_RS02925	COG4208	sulfate ABC transporter
FK537_RS02930	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FK537_RS02935	COG0583	DNA-binding transcription factor activity
FK537_RS02955	COG0602	queuosine metabolic process
FK537_RS02960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FK537_RS02970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FK537_RS02975	COG2353	YceI-like domain
FK537_RS02980	COG1051	belongs to the nudix hydrolase family
FK537_RS02980	COG1056	cytidyltransferase-related domain
FK537_RS02985	COG1024	Enoyl-CoA hydratase
FK537_RS02990	COG0778	Nitroreductase
FK537_RS03005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FK537_RS03005	COG0047	phosphoribosylformylglycinamidine synthase activity
FK537_RS03030	COG2310	stress, protein
FK537_RS03060	COG1358	cellular component organization or biogenesis
FK537_RS03090	COG2255	four-way junction helicase activity
FK537_RS03100	COG0824	Thioesterase
FK537_RS03120	COG0823	Involved in the tonB-independent uptake of proteins
FK537_RS03140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK537_RS03170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK537_RS03175	COG0628	permease
FK537_RS03180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FK537_RS03185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FK537_RS03205	COG0658	competence protein
FK537_RS03205	COG2333	competence protein COMEC
FK537_RS03210	COG1136	(ABC) transporter
FK537_RS03215	COG4591	ABC-type transport system involved in lipoprotein release permease component
FK537_RS03230	COG1671	Belongs to the UPF0178 family
FK537_RS03280	COG1280	lysine exporter protein (LysE YggA)
FK537_RS03285	COG1522	sequence-specific DNA binding
FK537_RS03295	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FK537_RS03310	COG0019	diaminopimelate decarboxylase activity
FK537_RS03320	COG1113	amino acid transport
FK537_RS03325	COG1115	amino acid carrier protein
FK537_RS03345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FK537_RS03350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FK537_RS03385	COG0583	DNA-binding transcription factor activity
FK537_RS03395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FK537_RS03405	COG0174	glutamine synthetase
FK537_RS03410	COG0512	Glutamine amidotransferase of anthranilate synthase
FK537_RS03440	COG3706	GGDEF domain
FK537_RS03455	COG3739	integral membrane protein
FK537_RS03460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FK537_RS03470	COG1741	Belongs to the pirin family
FK537_RS03475	COG3842	ATPase activity
FK537_RS03480	COG1840	ABC-type Fe3 transport system, periplasmic component
FK537_RS03500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK537_RS03505	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FK537_RS03515	COG0037	tRNA processing
FK537_RS03520	COG0739	heme binding
FK537_RS03520	COG0741	lytic transglycosylase activity
FK537_RS03520	COG1196	nuclear chromosome segregation
FK537_RS03525	COG0501	Belongs to the peptidase M48B family
FK537_RS03535	COG2239	Acts as a magnesium transporter
FK537_RS03570	COG1597	lipid kinase activity
FK537_RS03590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FK537_RS03625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FK537_RS03635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK537_RS03645	COG1534	Rna-binding protein
FK537_RS03660	COG0505	Belongs to the CarA family
FK537_RS03675	COG1309	transcriptional regulator
FK537_RS03680	COG0251	oxidation-reduction process
FK537_RS03685	COG0110	maltose O-acetyltransferase activity
FK537_RS03690	COG0589	response to stress
FK537_RS03700	COG2321	neutral zinc metallopeptidase
FK537_RS03705	COG2354	Protein conserved in bacteria
FK537_RS03720	COG2268	Band 7 protein
FK537_RS03725	COG3658	cytochrome
FK537_RS03730	COG1215	transferase activity, transferring glycosyl groups
FK537_RS03735	COG0726	polysaccharide deacetylase
FK537_RS03735	COG1649	PFAM Uncharacterised BCR, COG1649
FK537_RS03745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK537_RS03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK537_RS03770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK537_RS03775	COG1053	succinate dehydrogenase
FK537_RS03780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FK537_RS03810	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FK537_RS03825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FK537_RS03825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK537_RS03855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK537_RS03865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FK537_RS03895	COG0564	pseudouridine synthase activity
FK537_RS03905	COG0358	DNA primase activity
FK537_RS03920	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FK537_RS03950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK537_RS03990	COG0586	Pfam SNARE associated Golgi protein
FK537_RS04025	COG0321	lipoyl(octanoyl) transferase activity
FK537_RS04040	COG0531	amino acid
FK537_RS04045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FK537_RS04050	COG1648	precorrin-2 dehydrogenase activity
FK537_RS04050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FK537_RS04055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FK537_RS04065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FK537_RS04090	COG0671	phosphoesterase, PA-phosphatase related
FK537_RS04095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_RS04105	COG1538	Outer membrane efflux protein
FK537_RS04110	COG0393	Putative heavy-metal-binding
FK537_RS04115	COG0393	Putative heavy-metal-binding
FK537_RS04130	COG0525	valine-tRNA ligase activity
FK537_RS04140	COG2852	Protein conserved in bacteria
FK537_RS04175	COG3328	transposase activity
FK537_RS04185	COG2323	membrane
FK537_RS04200	COG0765	amino acid transport
FK537_RS04205	COG0765	amino acid transport
FK537_RS04210	COG1126	abc transporter atp-binding protein
FK537_RS04215	COG3338	carbonate dehydratase activity
FK537_RS04230	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK537_RS04245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK537_RS04250	COG2205	protein histidine kinase activity
FK537_RS04255	COG0745	RESPONSE REGULATOR receiver
FK537_RS04270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK537_RS04275	COG1652	LysM domain
FK537_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_RS04300	COG1399	metal-binding, possibly nucleic acid-binding protein
FK537_RS04305	COG3101	peptidyl-lysine hydroxylation
FK537_RS04310	COG0009	L-threonylcarbamoyladenylate synthase
FK537_RS04320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FK537_RS04325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FK537_RS04340	COG4106	trans-aconitate 2-methyltransferase activity
FK537_RS04355	COG0596	Alpha beta hydrolase
FK537_RS04355	COG2226	methyltransferase
FK537_RS04355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_RS04360	COG2193	ferroxidase activity
FK537_RS04365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FK537_RS04370	COG3115	cell septum assembly
FK537_RS04375	COG1196	nuclear chromosome segregation
FK537_RS04385	COG0730	response to heat
FK537_RS04405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FK537_RS04425	COG2801	Transposase and inactivated derivatives
FK537_RS04465	COG0628	permease
FK537_RS04475	COG2824	Alkylphosphonate utilization operon protein PhnA
FK537_RS04480	COG3189	MarR family transcriptional regulator
FK537_RS04495	COG0564	pseudouridine synthase activity
FK537_RS04530	COG0354	folic acid binding
FK537_RS04560	COG0363	glucosamine-6-phosphate deaminase activity
FK537_RS04570	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FK537_RS04575	COG1877	trehalose-phosphatase activity
FK537_RS04585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK537_RS04590	COG1970	mechanosensitive ion channel activity
FK537_RS04600	COG2233	PERMEase
FK537_RS04610	COG0833	amino acid
FK537_RS04630	COG0183	Belongs to the thiolase family
FK537_RS04645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_RS04655	COG2207	Transcriptional regulator
FK537_RS04660	COG0183	Belongs to the thiolase family
FK537_RS04665	COG1024	Enoyl-CoA hydratase
FK537_RS04665	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK537_RS04685	COG1272	protein, Hemolysin III
FK537_RS04690	COG0477	Major facilitator Superfamily
FK537_RS04700	COG1408	metallophosphoesterase
FK537_RS04705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK537_RS04715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FK537_RS04745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FK537_RS04750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK537_RS04755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FK537_RS04765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FK537_RS04770	COG0625	glutathione transferase activity
FK537_RS04775	COG2969	positive regulation of protein catabolic process
FK537_RS04830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK537_RS04875	COG0037	tRNA processing
FK537_RS04885	COG0248	Ppx GppA phosphatase
FK537_RS04910	COG0072	phenylalanine-tRNA ligase activity
FK537_RS04945	COG1238	metal cluster binding
FK537_RS04950	COG0625	glutathione transferase activity
FK537_RS04960	COG0675	Transposase, IS605 OrfB family
FK537_RS04980	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_RS04985	COG3028	Belongs to the UPF0307 family
FK537_RS04995	COG1660	Displays ATPase and GTPase activities
FK537_RS05010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FK537_RS05015	COG0617	tRNA 3'-terminal CCA addition
FK537_RS05020	COG1555	photosystem II stabilization
FK537_RS05025	COG3956	TIGRFAM MazG family protein
FK537_RS05040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK537_RS05050	COG0124	histidyl-tRNA synthetase
FK537_RS05080	COG2975	iron-sulfur cluster assembly
FK537_RS05120	COG0440	acetolactate synthase activity
FK537_RS05125	COG0028	Belongs to the TPP enzyme family
FK537_RS05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_RS05155	COG1136	(ABC) transporter
FK537_RS05155	COG0577	efflux transmembrane transporter activity
FK537_RS05220	COG4372	Transposase
FK537_RS05270	COG4372	Transposase
FK537_RS05295	COG3501	Rhs element vgr protein
FK537_RS05310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FK537_RS05315	COG1162	GTPase activity
FK537_RS05325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FK537_RS05335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FK537_RS05345	COG3781	membrane
FK537_RS05350	COG0613	PHP domain protein
FK537_RS05360	COG2350	Protein conserved in bacteria
FK537_RS05380	COG1666	GTP binding
FK537_RS05390	COG1607	acyl-coa hydrolase
FK537_RS05455	COG1183	phosphatidylcholine synthase activity
FK537_RS05460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FK537_RS05500	COG0739	heme binding
FK537_RS05500	COG0741	lytic transglycosylase activity
FK537_RS05500	COG1196	nuclear chromosome segregation
FK537_RS05510	COG1702	phosphate starvation-inducible protein PhoH
FK537_RS05575	COG1295	ribonuclease BN
FK537_RS05590	COG4372	Transposase
FK537_RS05620	COG0788	formyltetrahydrofolate deformylase activity
FK537_RS05645	COG4651	solute:proton antiporter activity
FK537_RS05645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FK537_RS05660	COG0724	RNA recognition motif
FK537_RS05665	COG0210	DNA helicase
FK537_RS05675	COG1929	Belongs to the glycerate kinase type-1 family
FK537_RS05705	COG2900	Belongs to the SlyX family
FK537_RS05715	COG1560	Kdo2-lipid A biosynthetic process
FK537_RS05770	COG0473	3-isopropylmalate dehydrogenase activity
FK537_RS05785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FK537_RS05800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK537_RS05815	COG0494	nUDIX hydrolase
FK537_RS05835	COG1960	acyl-CoA dehydrogenase activity
FK537_RS05845	COG0753	catalase activity
FK537_RS05860	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK537_RS05865	COG3384	dioxygenase
FK537_RS05870	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_RS05885	COG4638	Rieske (2fe-2S)
FK537_RS05890	COG0583	DNA-binding transcription factor activity
FK537_RS05915	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FK537_RS05920	COG3971	2-oxopent-4-enoate hydratase activity
FK537_RS05925	COG0546	phosphoglycolate phosphatase activity
FK537_RS05935	COG1530	ribonuclease E activity
FK537_RS05940	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_RS05975	COG1983	PspC domain protein
FK537_RS05980	COG0517	IMP dehydrogenase activity
FK537_RS05980	COG0617	tRNA 3'-terminal CCA addition
FK537_RS05980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK537_RS05990	COG0751	glycine-tRNA ligase activity
FK537_RS06015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK537_RS06040	COG0493	'glutamate synthase
FK537_RS06040	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK537_RS06050	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FK537_RS06060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK537_RS06075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FK537_RS06085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FK537_RS06085	COG0644	oxidoreductase
FK537_RS06290	COG3501	Rhs element vgr protein
FK537_RS06295	COG0425	Belongs to the sulfur carrier protein TusA family
FK537_RS06300	COG4535	Mg2 and Co2 transporter CorC
FK537_RS06305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FK537_RS06325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FK537_RS06335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FK537_RS06345	COG0789	Transcriptional regulator
FK537_RS06350	COG2841	Protein conserved in bacteria
FK537_RS06365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FK537_RS06375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK537_RS06380	COG1074	ATP-dependent DNA helicase activity
FK537_RS06385	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FK537_RS06415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK537_RS06425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FK537_RS06440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK537_RS06440	COG2111	Na H antiporter
FK537_RS06445	COG1006	Multisubunit Na H antiporter MnhC subunit
FK537_RS06450	COG0651	ATP synthesis coupled electron transport
FK537_RS06460	COG2212	antiporter activity
FK537_RS06470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FK537_RS06480	COG0195	Participates in both transcription termination and antitermination
FK537_RS06485	COG0779	Required for maturation of 30S ribosomal subunits
FK537_RS06535	COG0237	dephospho-CoA kinase activity
FK537_RS06545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK537_RS06550	COG3123	guanosine phosphorylase activity
FK537_RS06555	COG0497	DNA recombination
FK537_RS06565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FK537_RS06580	COG1132	(ABC) transporter
FK537_RS06585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FK537_RS06615	COG1024	Enoyl-CoA hydratase
FK537_RS06615	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK537_RS06625	COG2233	PERMEase
FK537_RS06635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FK537_RS06665	COG0326	Molecular chaperone. Has ATPase activity
FK537_RS06685	COG2056	Na+-H+ antiporter family
FK537_RS06705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FK537_RS06710	COG0085	RNA polymerase activity
FK537_RS06725	COG0081	regulation of translation
FK537_RS06810	COG0824	Thioesterase
FK537_RS06830	COG0181	hydroxymethylbilane synthase activity
FK537_RS06840	COG3275	phosphorelay sensor kinase activity
FK537_RS06875	COG0494	nUDIX hydrolase
FK537_RS06880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FK537_RS06885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FK537_RS06890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK537_RS06900	COG0772	Belongs to the SEDS family
FK537_RS06925	COG4974	Belongs to the 'phage' integrase family
FK537_RS06940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FK537_RS06950	COG2197	response regulator
FK537_RS06965	COG0793	Belongs to the peptidase S41A family
FK537_RS06970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FK537_RS06975	COG0795	lipopolysaccharide-transporting ATPase activity
FK537_RS06980	COG0795	lipopolysaccharide-transporting ATPase activity
FK537_RS07005	COG0586	Pfam SNARE associated Golgi protein
FK537_RS07020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK537_RS07020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK537_RS07030	COG0004	ammonium transporteR
FK537_RS07035	COG0347	Belongs to the P(II) protein family
FK537_RS07045	COG0606	chelatase, subunit chli
FK537_RS07060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FK537_RS07075	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_RS07085	COG0477	Major facilitator Superfamily
FK537_RS07090	COG2860	membrane
FK537_RS07100	COG1253	flavin adenine dinucleotide binding
FK537_RS07120	COG2814	Major facilitator Superfamily
FK537_RS07135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK537_RS07155	COG2814	Major facilitator Superfamily
FK537_RS07205	COG0758	DNA mediated transformation
FK537_RS07215	COG0697	spore germination
FK537_RS07220	COG0386	Belongs to the glutathione peroxidase family
FK537_RS07245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FK537_RS07295	COG1121	(ABC) transporter
FK537_RS07300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FK537_RS07310	COG2837	iron assimilation
FK537_RS07370	COG3501	Rhs element vgr protein
FK537_RS07375	COG0281	malic enzyme
FK537_RS07415	COG1715	Restriction endonuclease
FK537_RS07420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK537_RS07420	COG0519	Catalyzes the synthesis of GMP from XMP
FK537_RS07425	COG2259	Doxx family
FK537_RS07430	COG0586	Pfam SNARE associated Golgi protein
FK537_RS07445	COG1192	Involved in chromosome partitioning
FK537_RS07455	COG0271	Belongs to the BolA IbaG family
FK537_RS07490	COG3756	Protein conserved in bacteria
FK537_RS07570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FK537_RS07575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK537_RS07590	COG1570	exodeoxyribonuclease VII activity
FK537_RS07670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FK537_RS07685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FK537_RS07695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FK537_RS07705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK537_RS07720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FK537_RS07730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FK537_RS07740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FK537_RS07760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FK537_RS07765	COG1215	transferase activity, transferring glycosyl groups
FK537_RS07770	COG0463	Glycosyl transferase, family 2
FK537_RS07775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FK537_RS07780	COG2244	polysaccharide biosynthetic process
FK537_RS07810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FK537_RS07870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_RS07875	COG1309	transcriptional regulator
FK537_RS07885	COG2233	PERMEase
FK537_RS07915	COG0129	dihydroxy-acid dehydratase activity
FK537_RS07935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FK537_RS07945	COG0733	neurotransmitter:sodium symporter activity
FK537_RS07950	COG1012	belongs to the aldehyde dehydrogenase family
FK537_RS07960	COG2814	Major facilitator Superfamily
FK537_RS07990	COG0737	Belongs to the 5'-nucleotidase family
FK537_RS08015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FK537_RS08020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FK537_RS08045	COG0488	(ABC) transporter
FK537_RS08050	COG1063	alcohol dehydrogenase
FK537_RS08055	COG0187	DNA topoisomerase II activity
FK537_RS08065	COG0592	DNA-directed DNA polymerase activity
FK537_RS08070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK537_RS08080	COG0594	ribonuclease P activity
FK537_RS08085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FK537_RS08090	COG0706	membrane insertase activity
FK537_RS08125	COG1230	cation diffusion facilitator family transporter
FK537_RS08130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FK537_RS08150	COG0402	S-adenosylhomocysteine deaminase activity
FK537_RS08155	COG0861	Integral membrane protein TerC family
FK537_RS08165	COG2388	GCN5-related N-acetyl-transferase
FK537_RS08175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK537_RS08195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FK537_RS08205	COG2951	lytic endotransglycosylase activity
FK537_RS08250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK537_RS08280	COG2814	Major facilitator Superfamily
FK537_RS08285	COG2133	pyrroloquinoline quinone binding
FK537_RS08295	COG1047	Peptidyl-prolyl cis-trans
FK537_RS08300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FK537_RS08305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FK537_RS08310	COG0196	riboflavin kinase activity
FK537_RS08320	COG1309	transcriptional regulator
FK537_RS08335	COG1116	anion transmembrane transporter activity
FK537_RS08340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FK537_RS08345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK537_RS08350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK537_RS08355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK537_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_RS08390	COG0546	phosphoglycolate phosphatase activity
FK537_RS08395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FK537_RS08405	COG1309	transcriptional regulator
FK537_RS08410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FK537_RS08420	COG3023	N-Acetylmuramoyl-L-alanine amidase
FK537_RS08440	COG1064	alcohol dehydrogenase
FK537_RS08445	COG2818	Glycosylase
FK537_RS08455	COG0739	heme binding
FK537_RS08460	COG1194	a g-specific adenine glycosylase
FK537_RS08475	COG5487	UPF0391 membrane protein
FK537_RS08480	COG2983	Belongs to the UPF0260 family
FK537_RS08485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FK537_RS08490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FK537_RS08500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FK537_RS08505	COG2814	Major facilitator Superfamily
FK537_RS08510	COG1335	isochorismatase
FK537_RS08515	COG0385	Bile acid
FK537_RS08530	COG3830	Belongs to the UPF0237 family
FK537_RS08530	COG0560	Phosphoserine phosphatase
FK537_RS08550	COG0753	catalase activity
FK537_RS08605	COG2175	clavaminate synthase activity
FK537_RS08610	COG0534	Mate efflux family protein
FK537_RS08615	COG0436	Aminotransferase
FK537_RS08620	COG2733	membrane
FK537_RS08635	COG2918	glutathione biosynthetic process
FK537_RS08640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FK537_RS08650	COG3150	esterase
FK537_RS08690	COG0471	metal ion transport
FK537_RS08705	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FK537_RS08710	COG4266	Belongs to the allantoicase family
FK537_RS08715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK537_RS08720	COG1247	-acetyltransferase
FK537_RS08760	COG0625	glutathione transferase activity
FK537_RS08765	COG3706	GGDEF domain
FK537_RS08770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FK537_RS08785	COG1393	Belongs to the ArsC family
FK537_RS08790	COG0708	Exodeoxyribonuclease III
FK537_RS08835	COG4115	mRNA cleavage
FK537_RS08845	COG0189	ligase activity
FK537_RS08850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK537_RS08855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK537_RS08865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FK537_RS08875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FK537_RS08905	COG2119	membrane
FK537_RS08910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK537_RS08910	COG0426	domain, Protein
FK537_RS08935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FK537_RS08955	COG1902	pentaerythritol trinitrate reductase activity
FK537_RS08960	COG1519	Transferase
FK537_RS08965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK537_RS08970	COG0668	transmembrane transport
FK537_RS08975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK537_RS08985	COG0431	NADPH-dependent FMN reductase
FK537_RS09000	COG2205	protein histidine kinase activity
FK537_RS09000	COG0784	Response regulator, receiver
FK537_RS09005	COG3162	membrane
FK537_RS09010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK537_RS09030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FK537_RS09040	COG3706	GGDEF domain
FK537_RS09045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK537_RS09050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK537_RS09060	COG2814	Major facilitator Superfamily
FK537_RS09065	COG0629	single-stranded DNA binding
FK537_RS09080	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FK537_RS09105	COG3158	transport of potassium into the cell
FK537_RS09145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FK537_RS09160	COG0697	spore germination
FK537_RS09185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FK537_RS09215	COG0427	acetyl-CoA hydrolase
FK537_RS09220	COG2205	protein histidine kinase activity
FK537_RS09225	COG0745	RESPONSE REGULATOR receiver
FK537_RS09240	COG4221	oxidoreductase activity
FK537_RS09250	COG0488	(ABC) transporter
FK537_RS09270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK537_RS09280	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FK537_RS09285	COG0275	rRNA processing
FK537_RS09300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK537_RS09305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FK537_RS09315	COG2226	methyltransferase
FK537_RS09365	COG0067	glutamate synthase
FK537_RS09365	COG0070	glutamate synthase
FK537_RS09365	COG0069	glutamate synthase activity
FK537_RS09370	COG0493	'glutamate synthase
FK537_RS09380	COG1704	LemA family
FK537_RS09385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FK537_RS09405	COG3307	-O-antigen
FK537_RS09425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK537_RS09430	COG1758	RNA polymerase activity
FK537_RS09435	COG0194	GDP metabolic process
FK537_RS09480	COG0228	four-way junction DNA binding
FK537_RS09485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FK537_RS09495	COG0335	large ribosomal subunit rRNA binding
FK537_RS09505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FK537_RS09510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FK537_RS09515	COG5380	lipid catabolic process
FK537_RS09520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FK537_RS09545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FK537_RS09550	COG0277	FAD linked oxidase domain protein
FK537_RS09565	COG2814	Major facilitator Superfamily
FK537_RS09575	COG0628	permease
FK537_RS09580	COG1192	Involved in chromosome partitioning
FK537_RS09595	COG2226	methyltransferase
FK537_RS09615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FK537_RS09620	COG0254	rRNA binding
FK537_RS09625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK537_RS09630	COG0534	Mate efflux family protein
FK537_RS09640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK537_RS09645	COG1960	acyl-CoA dehydrogenase activity
FK537_RS09665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK537_RS09690	COG1127	ABC transporter
FK537_RS09695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK537_RS09700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FK537_RS09705	COG2854	intermembrane phospholipid transfer
FK537_RS09715	COG0598	Magnesium transport protein CorA
FK537_RS09730	COG1040	competence protein
FK537_RS09735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FK537_RS09745	COG2937	Belongs to the GPAT DAPAT family
FK537_RS09750	COG1946	Acyl-CoA thioesterase
FK537_RS09755	COG1301	dicarboxylic acid transport
FK537_RS09785	COG1959	2 iron, 2 sulfur cluster binding
FK537_RS09795	COG0433	COG0433 Predicted ATPase
FK537_RS09825	COG0088	Forms part of the polypeptide exit tunnel
FK537_RS09855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FK537_RS09890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FK537_RS09895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FK537_RS09905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FK537_RS09940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FK537_RS09945	COG0202	RNA polymerase activity
FK537_RS09955	COG2072	flavoprotein involved in K transport
FK537_RS09960	COG1960	acyl-CoA dehydrogenase activity
FK537_RS09965	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FK537_RS09985	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FK537_RS09990	COG0697	spore germination
FK537_RS10000	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FK537_RS10005	COG0339	signal peptide processing
FK537_RS10010	COG0557	exoribonuclease II activity
FK537_RS10045	COG0179	Fumarylacetoacetate (FAA) hydrolase
FK537_RS10075	COG3040	lipid binding
FK537_RS10135	COG2813	Specifically methylates the guanine in position
FK537_RS10135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_RS10140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_RS10145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FK537_RS10155	COG3128	pkhd-type hydroxylase
FK537_RS10160	COG4774	siderophore transport
FK537_RS10165	COG4771	TonB-dependent receptor
FK537_RS10175	COG0740	serine-type endopeptidase activity
FK537_RS10205	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FK537_RS10205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FK537_RS10230	COG0280	phosphate acetyltransferase
FK537_RS10230	COG0857	belongs to the CobB CobQ family
FK537_RS10235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FK537_RS10265	COG0793	Belongs to the peptidase S41A family
FK537_RS10310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FK537_RS10325	COG0084	hydrolase, TatD family'
FK537_RS10330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FK537_RS10335	COG3385	transposase activity
FK537_RS10340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FK537_RS10360	COG1546	Belongs to the CinA family
FK537_RS10360	COG1058	Belongs to the CinA family
FK537_RS10380	COG2814	Major facilitator Superfamily
FK537_RS10385	COG0697	spore germination
FK537_RS10410	COG3622	Belongs to the hyi family
FK537_RS10420	COG1024	Enoyl-CoA hydratase
FK537_RS10425	COG2205	protein histidine kinase activity
FK537_RS10425	COG0784	Response regulator, receiver
FK537_RS10425	COG5002	protein histidine kinase activity
FK537_RS10430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK537_RS10445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK537_RS10465	COG1862	Preprotein translocase
FK537_RS10480	COG1704	LemA family
FK537_RS10490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FK537_RS10505	COG3385	transposase activity
FK537_RS10510	COG5002	protein histidine kinase activity
FK537_RS10515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FK537_RS10570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FK537_RS10620	COG3385	transposase activity
FK537_RS10630	COG1960	acyl-CoA dehydrogenase activity
FK537_RS10635	COG1960	acyl-CoA dehydrogenase activity
FK537_RS10645	COG2205	protein histidine kinase activity
FK537_RS10650	COG0745	RESPONSE REGULATOR receiver
FK537_RS10660	COG2315	Protein conserved in bacteria
FK537_RS10665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FK537_RS10670	COG3385	transposase activity
FK537_RS10690	COG2096	Adenosyltransferase
FK537_RS10695	COG4206	TonB-dependent receptor
FK537_RS10740	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FK537_RS10745	COG0285	dihydrofolate synthase activity
FK537_RS10760	COG0450	alkyl hydroperoxide reductase
FK537_RS10775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FK537_RS10780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FK537_RS10810	COG2199	diguanylate cyclase activity
FK537_RS10870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FK537_RS10875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FK537_RS10925	COG0494	nUDIX hydrolase
FK537_RS10935	COG1214	PFAM Peptidase M22, glycoprotease
FK537_RS10940	COG1968	undecaprenyl-diphosphatase activity
FK537_RS10960	COG4269	membrane
FK537_RS10975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK537_RS10985	COG2132	Multicopper oxidase
FK537_RS10995	COG2076	Multidrug Resistance protein
FK537_RS11000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FK537_RS11015	COG0351	phosphomethylpyrimidine kinase
FK537_RS11015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK537_RS11015	COG0352	thiamine-phosphate diphosphorylase activity
FK537_RS11040	COG0251	oxidation-reduction process
FK537_RS11045	COG1113	amino acid transport
FK537_RS11065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FK537_RS11090	COG0456	acetyltransferase
FK537_RS11100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FK537_RS11105	COG0492	ferredoxin-NADP+ reductase activity
FK537_RS11110	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK537_RS11110	COG1674	ftsk spoiiie
FK537_RS11125	COG2894	cell division
FK537_RS11130	COG0850	regulation of cytokinetic process
FK537_RS11140	COG0204	Acyl-transferase
FK537_RS11145	COG2885	chlorophyll binding
FK537_RS11150	COG0210	DNA helicase
FK537_RS11160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK537_RS11175	COG0121	glutamine amidotransferase
FK537_RS11190	COG2914	Belongs to the UPF0125 (RnfH) family
FK537_RS11195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK537_RS11200	COG0735	belongs to the Fur family
FK537_RS11230	COG0420	3'-5' exonuclease activity
FK537_RS11250	COG2050	protein possibly involved in aromatic compounds catabolism
FK537_RS11255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FK537_RS11265	COG0582	viral genome integration into host DNA
FK537_RS11390	COG3177	Filamentation induced by cAMP protein fic
FK537_RS11445	COG1649	PFAM Uncharacterised BCR, COG1649
FK537_RS11445	COG0726	polysaccharide deacetylase
FK537_RS11450	COG1215	transferase activity, transferring glycosyl groups
FK537_RS11465	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FK537_RS11495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK537_RS11505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK537_RS11510	COG1077	Cell shape determining protein MreB Mrl
FK537_RS11515	COG1792	Involved in formation and maintenance of cell shape
FK537_RS11520	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FK537_RS11525	COG0424	maF-like protein
FK537_RS11530	COG1530	ribonuclease E activity
FK537_RS11540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FK537_RS11580	COG0625	glutathione transferase activity
FK537_RS11605	COG1113	amino acid transport
FK537_RS11610	COG2828	Protein conserved in bacteria
FK537_RS11615	COG0142	geranyltranstransferase activity
FK537_RS11625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK537_RS11645	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FK537_RS11655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FK537_RS11660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK537_RS11665	COG0839	Belongs to the complex I subunit 6 family
FK537_RS11670	COG0713	ATP synthesis coupled electron transport
FK537_RS11675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK537_RS11680	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK537_RS11695	COG1278	Cold shock
FK537_RS11700	COG1278	Cold shock
FK537_RS11705	COG0583	DNA-binding transcription factor activity
FK537_RS11730	COG0668	transmembrane transport
FK537_RS11745	COG2081	HI0933 family
FK537_RS11760	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FK537_RS11775	COG0004	ammonium transporteR
FK537_RS11790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK537_RS11790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK537_RS11795	COG0489	protein tyrosine kinase activity
FK537_RS11810	COG2358	TRAP transporter, solute receptor (TAXI family
FK537_RS11845	COG0442	prolyl-tRNA aminoacylation
FK537_RS11880	COG0840	transmembrane signaling receptor activity
FK537_RS11885	COG2198	Histidine kinase
FK537_RS11885	COG0643	Histidine kinase
FK537_RS11885	COG0784	Response regulator, receiver
FK537_RS11900	COG5510	response to toxic substance
FK537_RS11910	COG2832	Protein of unknown function (DUF454)
FK537_RS11915	COG1376	ErfK ybiS ycfS ynhG family protein
FK537_RS11970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FK537_RS11980	COG1289	transmembrane transporter activity
FK537_RS11985	COG2814	Major facilitator Superfamily
FK537_RS12000	COG0786	glutamate:sodium symporter activity
FK537_RS12005	COG1115	amino acid carrier protein
FK537_RS12010	COG2059	Chromate
FK537_RS12015	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK537_RS12025	COG1607	acyl-coa hydrolase
FK537_RS12035	COG2814	Major facilitator Superfamily
FK537_RS12040	COG0583	DNA-binding transcription factor activity
FK537_RS12060	COG0523	cobalamin synthesis protein
FK537_RS12065	COG4681	YaeQ
FK537_RS12075	COG2203	Gaf domain
FK537_RS12075	COG2199	diguanylate cyclase activity
FK537_RS12105	COG0477	Major facilitator Superfamily
FK537_RS12115	COG2066	Belongs to the glutaminase family
FK537_RS12120	COG2376	Dihydroxyacetone kinase
FK537_RS12145	COG0306	phosphate transporter
FK537_RS12170	COG4771	TonB-dependent receptor
FK537_RS12195	COG4181	ATPase activity
FK537_RS12200	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FK537_RS12210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK537_RS12220	COG0583	DNA-binding transcription factor activity
FK537_RS12230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_RS12235	COG1773	rubredoxin
FK537_RS12240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FK537_RS12275	COG3118	belongs to the thioredoxin family
FK537_RS12300	COG1253	flavin adenine dinucleotide binding
FK537_RS12320	COG3015	lipoprotein NlpE involved in copper resistance
FK537_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_RS12355	COG0804	urea catabolic process
FK537_RS12370	COG0830	nickel cation binding
FK537_RS12375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FK537_RS12385	COG0742	ribosomal rna small subunit methyltransferase
FK537_RS12390	COG0768	penicillin binding
FK537_RS12415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FK537_RS12420	COG2878	Part of a membrane complex involved in electron transport
FK537_RS12425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FK537_RS12435	COG3384	dioxygenase
FK537_RS12445	COG2234	aminopeptidase activity
FK537_RS12455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FK537_RS12475	COG2186	Transcriptional regulator
FK537_RS12485	COG0277	FAD linked oxidase domain protein
FK537_RS12515	COG3079	Belongs to the UPF0149 family
FK537_RS12520	COG0006	proline dipeptidase activity
FK537_RS12525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK537_RS12530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK537_RS12565	COG2816	NAD+ diphosphatase activity
FK537_RS12580	COG1388	LysM domain
FK537_RS12580	COG0741	lytic transglycosylase activity
FK537_RS12585	COG4166	transmembrane transport
FK537_RS12590	COG4174	ABC transporter (Permease)
FK537_RS12595	COG4239	(ABC) transporter, permease
FK537_RS12600	COG4172	Belongs to the ABC transporter superfamily
FK537_RS12630	COG0833	amino acid
FK537_RS12655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK537_RS12660	COG0418	dihydroorotase activity
FK537_RS12665	COG5001	Diguanylate cyclase
FK537_RS12665	COG4251	negative regulation of phosphorylation
FK537_RS12665	COG3706	GGDEF domain
FK537_RS12665	COG2203	Gaf domain
FK537_RS12680	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK537_RS12680	COG1902	pentaerythritol trinitrate reductase activity
FK537_RS12700	COG2871	sodium ion transport
FK537_RS12730	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FK537_RS12750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK537_RS12755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FK537_RS12760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FK537_RS12800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FK537_RS12810	COG2175	clavaminate synthase activity
FK537_RS12830	COG0052	Belongs to the universal ribosomal protein uS2 family
FK537_RS12855	COG2951	lytic endotransglycosylase activity
FK537_RS12870	COG0842	Transport permease protein
FK537_RS12875	COG1131	(ABC) transporter
FK537_RS12930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK537_RS12950	COG3634	alkyl hydroperoxide reductase activity
FK537_RS12955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK537_RS12970	COG0640	Transcriptional regulator
FK537_RS12980	COG0798	PFAM Bile acid sodium symporter
FK537_RS12985	COG0431	NADPH-dependent FMN reductase
FK537_RS12990	COG0789	Transcriptional regulator
FK537_RS13005	COG1720	tRNA m6t6A37 methyltransferase activity
FK537_RS13015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FK537_RS13025	COG0745	RESPONSE REGULATOR receiver
FK537_RS13030	COG0642	Histidine kinase
FK537_RS13050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK537_RS13055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FK537_RS13060	COG3139	Protein of unknown function (DUF1315)
FK537_RS13070	COG1301	dicarboxylic acid transport
FK537_RS13075	COG1960	acyl-CoA dehydrogenase activity
FK537_RS13080	COG0693	protein deglycase activity
FK537_RS13090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FK537_RS13095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FK537_RS13120	COG1047	Peptidyl-prolyl cis-trans
FK537_RS13125	COG1252	NADH dehydrogenase
FK537_RS13130	COG1686	Belongs to the peptidase S11 family
FK537_RS13145	COG1187	pseudouridine synthase activity
FK537_RS13160	COG0739	heme binding
FK537_RS13185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK537_RS13195	COG0612	Peptidase, M16
FK537_RS13230	COG0352	thiamine-phosphate diphosphorylase activity
FK537_RS13270	COG0596	Alpha beta hydrolase
FK537_RS13275	COG1309	transcriptional regulator
FK537_RS13295	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FK537_RS13295	COG2885	chlorophyll binding
FK537_RS13410	COG0110	maltose O-acetyltransferase activity
FK537_RS13430	COG0438	transferase activity, transferring glycosyl groups
FK537_RS13465	COG1278	Cold shock
FK537_RS13480	COG2070	2-Nitropropane dioxygenase
FK537_RS13505	COG2391	methyltransferase activity
FK537_RS13515	COG3634	alkyl hydroperoxide reductase activity
FK537_RS13545	COG1643	Atp-dependent helicase
FK537_RS13570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FK537_RS13570	COG0517	IMP dehydrogenase activity
FK537_RS13575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FK537_RS13585	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FK537_RS13590	COG1137	ATPase activity
FK537_RS13600	COG2274	protein secretion by the type I secretion system
FK537_RS13625	COG4122	O-methyltransferase activity
FK537_RS13635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FK537_RS13650	COG1454	alcohol dehydrogenase
FK537_RS13680	COG2011	ABC-type metal ion transport system permease component
FK537_RS13685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FK537_RS13705	COG0138	bifunctional purine biosynthesis protein purh
FK537_RS13710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FK537_RS13755	COG2308	Evidence 4 Homologs of previously reported genes of
FK537_RS13765	COG1305	Transglutaminase-like
FK537_RS13780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FK537_RS13795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FK537_RS13800	COG0360	Binds together with S18 to 16S ribosomal RNA
FK537_RS13810	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FK537_RS13815	COG1845	cytochrome c oxidase, subunit III
FK537_RS13820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK537_RS13825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FK537_RS13850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK537_RS13865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK537_RS13875	COG3781	membrane
FK537_RS13895	COG1960	acyl-CoA dehydrogenase activity
FK537_RS13900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK537_RS13910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FK537_RS13920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FK537_RS13940	COG0477	Major facilitator Superfamily
FK537_RS13980	COG0786	glutamate:sodium symporter activity
FK537_RS14010	COG0308	aminopeptidase N
FK537_RS14020	COG0589	response to stress
FK537_RS14025	COG0589	response to stress
FK537_RS14035	COG3135	benzoate transporter
FK537_RS14045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK537_RS14060	COG0183	Belongs to the thiolase family
FK537_RS14070	COG2030	dehydratase
FK537_RS14090	COG0824	Thioesterase
FK537_RS14095	COG1454	alcohol dehydrogenase
FK537_RS14100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FK537_RS14120	COG0069	glutamate synthase activity
FK537_RS14130	COG4585	Histidine kinase
FK537_RS14135	COG2850	peptidyl-arginine hydroxylation
FK537_RS14140	COG0424	maF-like protein
FK537_RS14165	COG0697	spore germination
FK537_RS14205	COG3698	Phosphodiester glycosidase
FK537_RS14225	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK537_RS14225	COG0506	proline dehydrogenase activity
FK537_RS14225	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK537_RS14235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK537_RS14240	COG1027	Aspartate ammonia-lyase
FK537_RS14245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FK537_RS14250	COG0583	DNA-binding transcription factor activity
FK537_RS14255	COG1960	acyl-CoA dehydrogenase activity
FK537_RS14275	COG1902	pentaerythritol trinitrate reductase activity
FK537_RS14275	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK537_RS14290	COG3385	transposase activity
FK537_RS14295	COG2814	Major facilitator Superfamily
FK537_RS14305	COG0583	DNA-binding transcription factor activity
FK537_RS14325	COG0148	phosphopyruvate hydratase activity
FK537_RS14340	COG0772	Belongs to the SEDS family
FK537_RS14355	COG2137	regulation of response to DNA damage stimulus
FK537_RS14365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FK537_RS14370	COG1011	Hydrolase
FK537_RS14390	COG0268	Binds directly to 16S ribosomal RNA
FK537_RS14395	COG0702	epimerase
FK537_RS14400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FK537_RS14415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FK537_RS14445	COG0316	Belongs to the HesB IscA family
FK537_RS14450	COG0822	iron-sulfur transferase activity
FK537_RS14480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK537_RS14535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FK537_RS14555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK537_RS14565	COG0133	tryptophan synthase activity
FK537_RS14570	COG3385	transposase activity
FK537_RS14575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK537_RS14575	COG0517	IMP dehydrogenase activity
FK537_RS14575	COG0617	tRNA 3'-terminal CCA addition
FK537_RS14605	COG0612	Peptidase, M16
FK537_RS14610	COG0552	protein localization to endoplasmic reticulum
FK537_RS14655	COG0693	protein deglycase activity
FK537_RS14665	COG1283	sodium-dependent phosphate transmembrane transporter activity
FK537_RS14675	COG1346	cytolysis
FK537_RS14685	COG0583	DNA-binding transcription factor activity
FK537_RS14705	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FK537_RS14710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK537_RS14740	COG1960	acyl-CoA dehydrogenase activity
FK537_RS14745	COG1917	Cupin 2, conserved barrel domain protein
FK537_RS14745	COG2207	Transcriptional regulator
FK537_RS14750	COG2814	Major facilitator Superfamily
FK537_RS14760	COG1271	oxidase subunit
FK537_RS14765	COG1294	oxidase, subunit
FK537_RS14775	COG1525	nuclease
FK537_RS14825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK537_RS14830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FK537_RS14845	COG1113	amino acid transport
FK537_RS14855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK537_RS14865	COG2814	Major facilitator Superfamily
FK537_RS14885	COG1132	(ABC) transporter
FK537_RS14900	COG0668	transmembrane transport
FK537_RS14905	COG3122	Protein conserved in bacteria
FK537_RS14925	COG0640	Transcriptional regulator
FK537_RS14930	COG2937	Belongs to the GPAT DAPAT family
FK537_RS14935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK537_RS14940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK537_RS14940	COG1116	anion transmembrane transporter activity
FK537_RS14950	COG2223	nitrite transmembrane transporter activity
FK537_RS14955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_RS14960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_RS14965	COG0243	molybdopterin cofactor binding
FK537_RS14975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FK537_RS14990	COG0315	cyclic pyranopterin monophosphate synthase activity
FK537_RS14990	COG0521	Mo-molybdopterin cofactor biosynthetic process
FK537_RS14995	COG0303	'Molybdopterin
FK537_RS15005	COG4149	molybdate abc transporter
FK537_RS15010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FK537_RS15015	COG0583	DNA-binding transcription factor activity
FK537_RS15035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_RS15040	COG0183	Belongs to the thiolase family
FK537_RS15045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FK537_RS15050	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FK537_RS15055	COG3135	benzoate transporter
FK537_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_RS15065	COG0543	2 iron, 2 sulfur cluster binding
FK537_RS15065	COG0633	Ferredoxin
FK537_RS15070	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FK537_RS15075	COG4638	Rieske (2fe-2S)
FK537_RS15085	COG4829	muconolactone delta-isomerase
FK537_RS15090	COG4948	Mandelate Racemase Muconate Lactonizing
FK537_RS15095	COG0583	DNA-binding transcription factor activity
FK537_RS15100	COG2814	Major facilitator Superfamily
FK537_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_RS15140	COG2223	nitrite transmembrane transporter activity
FK537_RS15150	COG0675	Transposase, IS605 OrfB family
FK537_RS15155	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FK537_RS15160	COG2116	formate transmembrane transporter activity
FK537_RS15165	COG0515	serine threonine protein kinase
FK537_RS15180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_RS15215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FK537_RS15220	COG1309	transcriptional regulator
FK537_RS15225	COG1012	belongs to the aldehyde dehydrogenase family
FK537_RS15245	COG0745	RESPONSE REGULATOR receiver
FK537_RS15255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK537_RS15275	COG2885	chlorophyll binding
FK537_RS15285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FK537_RS15290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK537_RS15295	COG0730	response to heat
FK537_RS15315	COG1309	transcriptional regulator
FK537_RS15335	COG3501	Rhs element vgr protein