locus-tag	class	description
FHP22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FHP22_RS00010	COG0592	DNA-directed DNA polymerase activity
FHP22_RS00020	COG0187	DNA topoisomerase II activity
FHP22_RS00040	COG1063	alcohol dehydrogenase
FHP22_RS00045	COG0488	(ABC) transporter
FHP22_RS00070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FHP22_RS00075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FHP22_RS00100	COG0737	Belongs to the 5'-nucleotidase family
FHP22_RS00130	COG2814	Major facilitator Superfamily
FHP22_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
FHP22_RS00170	COG0733	neurotransmitter:sodium symporter activity
FHP22_RS00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FHP22_RS00200	COG0129	dihydroxy-acid dehydratase activity
FHP22_RS00215	COG2233	PERMEase
FHP22_RS00225	COG1309	transcriptional regulator
FHP22_RS00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FHP22_RS00300	COG0438	transferase activity, transferring glycosyl groups
FHP22_RS00305	COG1215	transferase activity, transferring glycosyl groups
FHP22_RS00320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FHP22_RS00330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHP22_RS00340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FHP22_RS00355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FHP22_RS00405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FHP22_RS00415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FHP22_RS00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FHP22_RS00475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHP22_RS00495	COG0659	secondary active sulfate transmembrane transporter activity
FHP22_RS00510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FHP22_RS00515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FHP22_RS00540	COG1570	exodeoxyribonuclease VII activity
FHP22_RS00555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FHP22_RS00560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHP22_RS00565	COG2194	sulfuric ester hydrolase activity
FHP22_RS00570	COG0745	RESPONSE REGULATOR receiver
FHP22_RS00575	COG0642	Histidine kinase
FHP22_RS00655	COG3586	endonuclease activity
FHP22_RS00675	COG3756	Protein conserved in bacteria
FHP22_RS00710	COG0271	Belongs to the BolA IbaG family
FHP22_RS00720	COG1192	Involved in chromosome partitioning
FHP22_RS00735	COG0586	Pfam SNARE associated Golgi protein
FHP22_RS00740	COG2259	Doxx family
FHP22_RS00745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FHP22_RS00745	COG0519	Catalyzes the synthesis of GMP from XMP
FHP22_RS00785	COG0281	malic enzyme
FHP22_RS00795	COG3179	chitinase
FHP22_RS00835	COG2837	iron assimilation
FHP22_RS00845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FHP22_RS00850	COG1121	(ABC) transporter
FHP22_RS00900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FHP22_RS00925	COG0386	Belongs to the glutathione peroxidase family
FHP22_RS00930	COG0697	spore germination
FHP22_RS00945	COG0758	DNA mediated transformation
FHP22_RS00995	COG2814	Major facilitator Superfamily
FHP22_RS01020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FHP22_RS01035	COG2814	Major facilitator Superfamily
FHP22_RS01055	COG1253	flavin adenine dinucleotide binding
FHP22_RS01065	COG2860	membrane
FHP22_RS01070	COG0477	Major facilitator Superfamily
FHP22_RS01080	COG0318	PFAM AMP-dependent synthetase and ligase
FHP22_RS01095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FHP22_RS01110	COG0606	chelatase, subunit chli
FHP22_RS01120	COG0347	Belongs to the P(II) protein family
FHP22_RS01125	COG0004	ammonium transporteR
FHP22_RS01135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FHP22_RS01135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FHP22_RS01150	COG0586	Pfam SNARE associated Golgi protein
FHP22_RS01175	COG0795	lipopolysaccharide-transporting ATPase activity
FHP22_RS01180	COG0795	lipopolysaccharide-transporting ATPase activity
FHP22_RS01185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FHP22_RS01190	COG0793	Belongs to the peptidase S41A family
FHP22_RS01205	COG2197	response regulator
FHP22_RS01215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FHP22_RS01230	COG4974	Belongs to the 'phage' integrase family
FHP22_RS01255	COG0772	Belongs to the SEDS family
FHP22_RS01265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FHP22_RS01270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FHP22_RS01275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FHP22_RS01280	COG0494	nUDIX hydrolase
FHP22_RS01325	COG3275	phosphorelay sensor kinase activity
FHP22_RS01335	COG0181	hydroxymethylbilane synthase activity
FHP22_RS01355	COG0824	Thioesterase
FHP22_RS01440	COG0081	regulation of translation
FHP22_RS01455	COG0085	RNA polymerase activity
FHP22_RS01460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FHP22_RS01480	COG2056	Na+-H+ antiporter family
FHP22_RS01500	COG0326	Molecular chaperone. Has ATPase activity
FHP22_RS01520	COG2801	Transposase and inactivated derivatives
FHP22_RS01550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FHP22_RS01560	COG2233	PERMEase
FHP22_RS01570	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHP22_RS01570	COG1024	Enoyl-CoA hydratase
FHP22_RS01590	COG0322	excinuclease ABC activity
FHP22_RS01600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FHP22_RS01605	COG1132	(ABC) transporter
FHP22_RS01620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FHP22_RS01630	COG0497	DNA recombination
FHP22_RS01635	COG3123	guanosine phosphorylase activity
FHP22_RS01640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHP22_RS01650	COG0237	dephospho-CoA kinase activity
FHP22_RS01700	COG0779	Required for maturation of 30S ribosomal subunits
FHP22_RS01705	COG0195	Participates in both transcription termination and antitermination
FHP22_RS01715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FHP22_RS01720	COG1320	monovalent cation:proton antiporter activity
FHP22_RS01725	COG2212	antiporter activity
FHP22_RS01730	COG1863	multisubunit Na H antiporter MnhE subunit
FHP22_RS01735	COG0651	ATP synthesis coupled electron transport
FHP22_RS01740	COG1006	Multisubunit Na H antiporter MnhC subunit
FHP22_RS01745	COG2111	Na H antiporter
FHP22_RS01745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FHP22_RS01760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FHP22_RS01770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FHP22_RS01800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FHP22_RS01805	COG1074	ATP-dependent DNA helicase activity
FHP22_RS01810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FHP22_RS01815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FHP22_RS01830	COG2841	Protein conserved in bacteria
FHP22_RS01835	COG0789	Transcriptional regulator
FHP22_RS01845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FHP22_RS01855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FHP22_RS01875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FHP22_RS01880	COG4535	Mg2 and Co2 transporter CorC
FHP22_RS01885	COG0425	Belongs to the sulfur carrier protein TusA family
FHP22_RS01955	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FHP22_RS01955	COG0644	oxidoreductase
FHP22_RS01965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FHP22_RS01980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHP22_RS01990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FHP22_RS02000	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FHP22_RS02000	COG0493	'glutamate synthase
FHP22_RS02010	COG2226	methyltransferase
FHP22_RS02025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FHP22_RS02055	COG0751	glycine-tRNA ligase activity
FHP22_RS02065	COG0517	IMP dehydrogenase activity
FHP22_RS02065	COG0617	tRNA 3'-terminal CCA addition
FHP22_RS02065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FHP22_RS02070	COG1983	PspC domain protein
FHP22_RS02095	COG0318	PFAM AMP-dependent synthetase and ligase
FHP22_RS02100	COG1530	ribonuclease E activity
FHP22_RS02115	COG0546	phosphoglycolate phosphatase activity
FHP22_RS02120	COG3971	2-oxopent-4-enoate hydratase activity
FHP22_RS02125	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FHP22_RS02170	COG0583	DNA-binding transcription factor activity
FHP22_RS02175	COG4638	Rieske (2fe-2S)
FHP22_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
FHP22_RS02195	COG3384	dioxygenase
FHP22_RS02200	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHP22_RS02215	COG0753	catalase activity
FHP22_RS02225	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS02245	COG0494	nUDIX hydrolase
FHP22_RS02260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FHP22_RS02275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FHP22_RS02290	COG0473	3-isopropylmalate dehydrogenase activity
FHP22_RS02340	COG1560	Kdo2-lipid A biosynthetic process
FHP22_RS02345	COG0488	(ABC) transporter
FHP22_RS02350	COG2900	Belongs to the SlyX family
FHP22_RS02380	COG1929	Belongs to the glycerate kinase type-1 family
FHP22_RS02390	COG0210	DNA helicase
FHP22_RS02395	COG0724	RNA recognition motif
FHP22_RS02410	COG4651	solute:proton antiporter activity
FHP22_RS02410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FHP22_RS02435	COG0788	formyltetrahydrofolate deformylase activity
FHP22_RS02465	COG1295	ribonuclease BN
FHP22_RS02525	COG1702	phosphate starvation-inducible protein PhoH
FHP22_RS02535	COG1196	nuclear chromosome segregation
FHP22_RS02535	COG0741	lytic transglycosylase activity
FHP22_RS02535	COG0739	heme binding
FHP22_RS02575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FHP22_RS02580	COG1183	phosphatidylcholine synthase activity
FHP22_RS02645	COG1607	acyl-coa hydrolase
FHP22_RS02655	COG1666	GTP binding
FHP22_RS02675	COG2350	Protein conserved in bacteria
FHP22_RS02685	COG0613	PHP domain protein
FHP22_RS02690	COG3781	membrane
FHP22_RS02700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FHP22_RS02710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FHP22_RS02720	COG1162	GTPase activity
FHP22_RS02725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FHP22_RS02755	COG1388	LysM domain
FHP22_RS02755	COG3942	CHAP domain
FHP22_RS02780	COG1538	Outer membrane efflux protein
FHP22_RS02785	COG0577	efflux transmembrane transporter activity
FHP22_RS02785	COG1136	(ABC) transporter
FHP22_RS02790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FHP22_RS02815	COG0028	Belongs to the TPP enzyme family
FHP22_RS02820	COG0440	acetolactate synthase activity
FHP22_RS02870	COG2975	iron-sulfur cluster assembly
FHP22_RS02900	COG0124	histidyl-tRNA synthetase
FHP22_RS02910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FHP22_RS02925	COG3956	TIGRFAM MazG family protein
FHP22_RS02930	COG1555	photosystem II stabilization
FHP22_RS02935	COG0617	tRNA 3'-terminal CCA addition
FHP22_RS02940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FHP22_RS02955	COG1660	Displays ATPase and GTPase activities
FHP22_RS02965	COG3028	Belongs to the UPF0307 family
FHP22_RS02970	COG0318	PFAM AMP-dependent synthetase and ligase
FHP22_RS02985	COG0625	glutathione transferase activity
FHP22_RS02990	COG1238	metal cluster binding
FHP22_RS03025	COG0072	phenylalanine-tRNA ligase activity
FHP22_RS03050	COG0248	Ppx GppA phosphatase
FHP22_RS03060	COG0037	tRNA processing
FHP22_RS03105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FHP22_RS03160	COG2969	positive regulation of protein catabolic process
FHP22_RS03165	COG0625	glutathione transferase activity
FHP22_RS03170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FHP22_RS03180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FHP22_RS03185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FHP22_RS03190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FHP22_RS03220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FHP22_RS03230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHP22_RS03235	COG1408	metallophosphoesterase
FHP22_RS03245	COG0477	Major facilitator Superfamily
FHP22_RS03250	COG1272	protein, Hemolysin III
FHP22_RS03275	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHP22_RS03275	COG1024	Enoyl-CoA hydratase
FHP22_RS03280	COG0183	Belongs to the thiolase family
FHP22_RS03285	COG2207	Transcriptional regulator
FHP22_RS03290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FHP22_RS03295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FHP22_RS03310	COG0183	Belongs to the thiolase family
FHP22_RS03330	COG0833	amino acid
FHP22_RS03340	COG2233	PERMEase
FHP22_RS03345	COG1217	gtp-binding protein TYPA
FHP22_RS03350	COG1970	mechanosensitive ion channel activity
FHP22_RS03355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHP22_RS03365	COG1877	trehalose-phosphatase activity
FHP22_RS03370	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FHP22_RS03380	COG0363	glucosamine-6-phosphate deaminase activity
FHP22_RS03410	COG0354	folic acid binding
FHP22_RS03440	COG0346	lactoylglutathione lyase activity
FHP22_RS03445	COG0564	pseudouridine synthase activity
FHP22_RS03460	COG3189	MarR family transcriptional regulator
FHP22_RS03465	COG2824	Alkylphosphonate utilization operon protein PhnA
FHP22_RS03475	COG0628	permease
FHP22_RS03490	COG2801	Transposase and inactivated derivatives
FHP22_RS03500	COG3077	Addiction module antitoxin, RelB DinJ family
FHP22_RS03535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FHP22_RS03555	COG0730	response to heat
FHP22_RS03565	COG1196	nuclear chromosome segregation
FHP22_RS03570	COG3115	cell septum assembly
FHP22_RS03575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FHP22_RS03580	COG2193	ferroxidase activity
FHP22_RS03585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHP22_RS03585	COG0596	Alpha beta hydrolase
FHP22_RS03585	COG2226	methyltransferase
FHP22_RS03600	COG4106	trans-aconitate 2-methyltransferase activity
FHP22_RS03615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FHP22_RS03620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FHP22_RS03630	COG0009	L-threonylcarbamoyladenylate synthase
FHP22_RS03635	COG3101	peptidyl-lysine hydroxylation
FHP22_RS03640	COG1399	metal-binding, possibly nucleic acid-binding protein
FHP22_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
FHP22_RS03665	COG1652	LysM domain
FHP22_RS03670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHP22_RS03685	COG0745	RESPONSE REGULATOR receiver
FHP22_RS03690	COG2205	protein histidine kinase activity
FHP22_RS03695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FHP22_RS03710	COG1752	Esterase of the alpha-beta hydrolase superfamily
FHP22_RS03725	COG3338	carbonate dehydratase activity
FHP22_RS03730	COG1126	abc transporter atp-binding protein
FHP22_RS03735	COG0765	amino acid transport
FHP22_RS03740	COG0765	amino acid transport
FHP22_RS03750	COG2323	membrane
FHP22_RS03770	COG3328	transposase activity
FHP22_RS03785	COG0525	valine-tRNA ligase activity
FHP22_RS03800	COG0393	Putative heavy-metal-binding
FHP22_RS03805	COG0393	Putative heavy-metal-binding
FHP22_RS03815	COG1538	Outer membrane efflux protein
FHP22_RS03825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FHP22_RS03830	COG0671	phosphoesterase, PA-phosphatase related
FHP22_RS03855	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FHP22_RS03865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FHP22_RS03870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FHP22_RS03870	COG1648	precorrin-2 dehydrogenase activity
FHP22_RS03875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FHP22_RS03880	COG0531	amino acid
FHP22_RS03900	COG0321	lipoyl(octanoyl) transferase activity
FHP22_RS03910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FHP22_RS03935	COG0586	Pfam SNARE associated Golgi protein
FHP22_RS03975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FHP22_RS04005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FHP22_RS04020	COG0358	DNA primase activity
FHP22_RS04040	COG0564	pseudouridine synthase activity
FHP22_RS04055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FHP22_RS04065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FHP22_RS04095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FHP22_RS04095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FHP22_RS04110	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FHP22_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
FHP22_RS04125	COG2072	flavoprotein involved in K transport
FHP22_RS04140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FHP22_RS04145	COG1053	succinate dehydrogenase
FHP22_RS04150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FHP22_RS04165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FHP22_RS04175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FHP22_RS04185	COG1649	PFAM Uncharacterised BCR, COG1649
FHP22_RS04185	COG0726	polysaccharide deacetylase
FHP22_RS04190	COG1215	transferase activity, transferring glycosyl groups
FHP22_RS04200	COG2268	Band 7 protein
FHP22_RS04215	COG2354	Protein conserved in bacteria
FHP22_RS04220	COG2321	neutral zinc metallopeptidase
FHP22_RS04230	COG0589	response to stress
FHP22_RS04235	COG0110	maltose O-acetyltransferase activity
FHP22_RS04240	COG0415	Belongs to the DNA photolyase family
FHP22_RS04255	COG0505	Belongs to the CarA family
FHP22_RS04270	COG1534	Rna-binding protein
FHP22_RS04280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FHP22_RS04290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FHP22_RS04325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FHP22_RS04345	COG1597	lipid kinase activity
FHP22_RS04380	COG2239	Acts as a magnesium transporter
FHP22_RS04390	COG0501	Belongs to the peptidase M48B family
FHP22_RS04395	COG0739	heme binding
FHP22_RS04395	COG0741	lytic transglycosylase activity
FHP22_RS04395	COG1196	nuclear chromosome segregation
FHP22_RS04400	COG0037	tRNA processing
FHP22_RS04410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FHP22_RS04415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FHP22_RS04435	COG1840	ABC-type Fe3 transport system, periplasmic component
FHP22_RS04440	COG3842	ATPase activity
FHP22_RS04445	COG1741	Belongs to the pirin family
FHP22_RS04460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FHP22_RS04465	COG3739	integral membrane protein
FHP22_RS04480	COG3706	GGDEF domain
FHP22_RS04490	COG0302	gtp cyclohydrolase
FHP22_RS04510	COG0512	Glutamine amidotransferase of anthranilate synthase
FHP22_RS04515	COG0174	glutamine synthetase
FHP22_RS04525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FHP22_RS04535	COG0583	DNA-binding transcription factor activity
FHP22_RS04570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FHP22_RS04575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FHP22_RS04595	COG1115	amino acid carrier protein
FHP22_RS04600	COG1113	amino acid transport
FHP22_RS04610	COG0019	diaminopimelate decarboxylase activity
FHP22_RS04625	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FHP22_RS04635	COG1522	sequence-specific DNA binding
FHP22_RS04640	COG1280	lysine exporter protein (LysE YggA)
FHP22_RS04680	COG1671	Belongs to the UPF0178 family
FHP22_RS04695	COG4591	ABC-type transport system involved in lipoprotein release permease component
FHP22_RS04700	COG1136	(ABC) transporter
FHP22_RS04705	COG2333	competence protein COMEC
FHP22_RS04705	COG0658	competence protein
FHP22_RS04725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FHP22_RS04730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FHP22_RS04735	COG0628	permease
FHP22_RS04740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FHP22_RS04770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHP22_RS04790	COG0823	Involved in the tonB-independent uptake of proteins
FHP22_RS04810	COG0824	Thioesterase
FHP22_RS04820	COG2255	four-way junction helicase activity
FHP22_RS04850	COG1358	cellular component organization or biogenesis
FHP22_RS04900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FHP22_RS04900	COG0047	phosphoribosylformylglycinamidine synthase activity
FHP22_RS04915	COG0778	Nitroreductase
FHP22_RS04920	COG1024	Enoyl-CoA hydratase
FHP22_RS04925	COG1051	belongs to the nudix hydrolase family
FHP22_RS04925	COG1056	cytidyltransferase-related domain
FHP22_RS04930	COG2353	YceI-like domain
FHP22_RS04935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FHP22_RS04945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FHP22_RS04950	COG0602	queuosine metabolic process
FHP22_RS04970	COG0583	DNA-binding transcription factor activity
FHP22_RS04975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FHP22_RS04980	COG4208	sulfate ABC transporter
FHP22_RS04995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FHP22_RS05005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FHP22_RS05020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHP22_RS05030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHP22_RS05045	COG0681	Belongs to the peptidase S26 family
FHP22_RS05055	COG0571	ribonuclease III activity
FHP22_RS05060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FHP22_RS05070	COG1381	Involved in DNA repair and RecF pathway recombination
FHP22_RS05075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FHP22_RS05100	COG0436	Aminotransferase
FHP22_RS05135	COG0556	nucleotide-excision repair
FHP22_RS05165	COG0702	epimerase
FHP22_RS05170	COG1733	regulation of RNA biosynthetic process
FHP22_RS05175	COG2814	Major facilitator Superfamily
FHP22_RS05185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FHP22_RS05190	COG0582	viral genome integration into host DNA
FHP22_RS05265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FHP22_RS05270	COG0076	glutamate decarboxylase activity
FHP22_RS05280	COG0573	inorganic phosphate transmembrane transporter activity
FHP22_RS05290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FHP22_RS05295	COG0616	signal peptide processing
FHP22_RS05330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FHP22_RS05335	COG1686	Belongs to the peptidase S11 family
FHP22_RS05350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FHP22_RS05360	COG0583	DNA-binding transcription factor activity
FHP22_RS05365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FHP22_RS05370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FHP22_RS05375	COG1067	ATP-dependent peptidase activity
FHP22_RS05410	COG1509	lysine 2,3-aminomutase activity
FHP22_RS05415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FHP22_RS05420	COG1966	Carbon starvation protein
FHP22_RS05425	COG2879	small protein
FHP22_RS05430	COG0714	Associated with various cellular activities
FHP22_RS05455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHP22_RS05530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHP22_RS05580	COG4695	Portal protein
FHP22_RS05750	COG1401	restriction endodeoxyribonuclease activity
FHP22_RS05750	COG1401	restriction endodeoxyribonuclease activity
FHP22_RS05785	COG2252	PERMEase
FHP22_RS05790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FHP22_RS05800	COG1215	transferase activity, transferring glycosyl groups
FHP22_RS05810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FHP22_RS05820	COG0527	aspartate kinase activity
FHP22_RS05830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FHP22_RS05845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FHP22_RS05850	COG0501	Belongs to the peptidase M48B family
FHP22_RS05865	COG0667	Aldo Keto reductase
FHP22_RS05875	COG1765	OsmC-like protein
FHP22_RS05895	COG0540	Belongs to the ATCase OTCase family
FHP22_RS05910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FHP22_RS05925	COG4770	biotin carboxylase activity
FHP22_RS05930	COG1024	Enoyl-CoA hydratase
FHP22_RS05935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FHP22_RS05940	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS05945	COG1309	transcriptional regulator
FHP22_RS05950	COG0318	PFAM AMP-dependent synthetase and ligase
FHP22_RS05970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FHP22_RS05980	COG0659	secondary active sulfate transmembrane transporter activity
FHP22_RS06000	COG2363	Small membrane protein
FHP22_RS06020	COG0513	Belongs to the DEAD box helicase family
FHP22_RS06085	COG4783	chaperone-mediated protein folding
FHP22_RS06100	COG1610	YqeY-like protein
FHP22_RS06130	COG0515	serine threonine protein kinase
FHP22_RS06130	COG2815	serine threonine protein kinase
FHP22_RS06170	COG2755	lipolytic protein G-D-S-L family
FHP22_RS06170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FHP22_RS06175	COG0436	Aminotransferase
FHP22_RS06180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHP22_RS06185	COG0386	Belongs to the glutathione peroxidase family
FHP22_RS06195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FHP22_RS06210	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FHP22_RS06220	COG0012	GTP binding
FHP22_RS06245	COG0204	Acyl-transferase
FHP22_RS06285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FHP22_RS06290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FHP22_RS06295	COG0022	dehydrogenase e1 component
FHP22_RS06300	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHP22_RS06305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FHP22_RS06315	COG1063	alcohol dehydrogenase
FHP22_RS06325	COG3328	transposase activity
FHP22_RS06345	COG1024	Enoyl-CoA hydratase
FHP22_RS06350	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHP22_RS06355	COG0183	Belongs to the thiolase family
FHP22_RS06360	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FHP22_RS06365	COG3327	negative regulation of DNA-templated transcription, initiation
FHP22_RS06375	COG0318	PFAM AMP-dependent synthetase and ligase
FHP22_RS06395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FHP22_RS06400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FHP22_RS06400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FHP22_RS06405	COG1254	Belongs to the acylphosphatase family
FHP22_RS06445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FHP22_RS06450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FHP22_RS06460	COG2353	YceI-like domain
FHP22_RS06470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FHP22_RS06470	COG0519	Catalyzes the synthesis of GMP from XMP
FHP22_RS06490	COG1454	alcohol dehydrogenase
FHP22_RS06500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FHP22_RS06505	COG0583	DNA-binding transcription factor activity
FHP22_RS06515	COG2707	UPF0756 membrane protein
FHP22_RS06540	COG0802	atpase or kinase
FHP22_RS06545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FHP22_RS06555	COG1923	regulation of RNA biosynthetic process
FHP22_RS06560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHP22_RS06570	COG3178	'Phosphotransferase
FHP22_RS06575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FHP22_RS06585	COG1192	Involved in chromosome partitioning
FHP22_RS06590	COG1475	DNA binding
FHP22_RS06595	COG0811	peptide transport
FHP22_RS06605	COG1132	(ABC) transporter
FHP22_RS06610	COG1663	tetraacyldisaccharide 4'-kinase activity
FHP22_RS06630	COG0084	hydrolase, TatD family'
FHP22_RS06665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FHP22_RS06695	COG0776	regulation of translation
FHP22_RS06705	COG0284	orotidine-5'-phosphate decarboxylase activity
FHP22_RS06710	COG2431	L-lysine efflux transmembrane transporter activity
FHP22_RS06725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FHP22_RS06735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FHP22_RS06760	COG1253	flavin adenine dinucleotide binding
FHP22_RS06765	COG3385	transposase activity
FHP22_RS06795	COG0583	DNA-binding transcription factor activity
FHP22_RS06810	COG3852	Histidine kinase
FHP22_RS06825	COG0233	cytoplasmic translational termination
FHP22_RS06830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FHP22_RS06835	COG0575	Belongs to the CDS family
FHP22_RS06850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FHP22_RS06870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FHP22_RS06900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FHP22_RS06905	COG0730	response to heat
FHP22_RS06910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FHP22_RS06915	COG2207	Transcriptional regulator
FHP22_RS06920	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FHP22_RS06930	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS06935	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS06970	COG4890	Cyd operon protein YbgT
FHP22_RS06975	COG1294	oxidase, subunit
FHP22_RS06990	COG1585	Membrane protein implicated in regulation of membrane protease activity
FHP22_RS07000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FHP22_RS07020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FHP22_RS07025	COG0569	domain protein
FHP22_RS07035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FHP22_RS07055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FHP22_RS07060	COG0542	response to heat
FHP22_RS07095	COG0372	Belongs to the citrate synthase family
FHP22_RS07105	COG1546	Belongs to the CinA family
FHP22_RS07105	COG1058	Belongs to the CinA family
FHP22_RS07140	COG2814	Major facilitator Superfamily
FHP22_RS07155	COG0439	Biotin carboxylase
FHP22_RS07160	COG0511	ligase activity, forming carbon-carbon bonds
FHP22_RS07195	COG0596	Alpha beta hydrolase
FHP22_RS07290	COG2801	Transposase and inactivated derivatives
FHP22_RS07300	COG2801	Transposase and inactivated derivatives
FHP22_RS07420	COG0730	response to heat
FHP22_RS07425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FHP22_RS07430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FHP22_RS07440	COG2885	chlorophyll binding
FHP22_RS07465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHP22_RS07495	COG1012	belongs to the aldehyde dehydrogenase family
FHP22_RS07500	COG1309	transcriptional regulator
FHP22_RS07505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FHP22_RS07540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FHP22_RS07570	COG0318	PFAM AMP-dependent synthetase and ligase
FHP22_RS07580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FHP22_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
FHP22_RS07590	COG1846	Transcriptional regulator
FHP22_RS07595	COG2814	Major facilitator Superfamily
FHP22_RS07610	COG0318	PFAM AMP-dependent synthetase and ligase
FHP22_RS07625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHP22_RS07625	COG0596	Alpha beta hydrolase
FHP22_RS07625	COG2226	methyltransferase
FHP22_RS07630	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS07640	COG1024	Enoyl-CoA hydratase
FHP22_RS07645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FHP22_RS07650	COG0235	Class ii aldolase
FHP22_RS07660	COG0183	Belongs to the thiolase family
FHP22_RS07665	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHP22_RS07670	COG1024	Enoyl-CoA hydratase
FHP22_RS07675	COG2814	Major facilitator Superfamily
FHP22_RS07685	COG2814	Major facilitator Superfamily
FHP22_RS07690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FHP22_RS07695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FHP22_RS07700	COG2814	Major facilitator Superfamily
FHP22_RS07705	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS07710	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS07720	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FHP22_RS07720	COG0644	oxidoreductase
FHP22_RS07725	COG0515	serine threonine protein kinase
FHP22_RS07730	COG2116	formate transmembrane transporter activity
FHP22_RS07735	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FHP22_RS07750	COG2223	nitrite transmembrane transporter activity
FHP22_RS07790	COG2814	Major facilitator Superfamily
FHP22_RS07795	COG0583	DNA-binding transcription factor activity
FHP22_RS07800	COG4948	Mandelate Racemase Muconate Lactonizing
FHP22_RS07805	COG4829	muconolactone delta-isomerase
FHP22_RS07815	COG4638	Rieske (2fe-2S)
FHP22_RS07820	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FHP22_RS07825	COG0633	Ferredoxin
FHP22_RS07825	COG0543	2 iron, 2 sulfur cluster binding
FHP22_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
FHP22_RS07835	COG3135	benzoate transporter
FHP22_RS07840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FHP22_RS07845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FHP22_RS07850	COG0183	Belongs to the thiolase family
FHP22_RS07855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHP22_RS07880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FHP22_RS07885	COG4149	molybdate abc transporter
FHP22_RS07890	COG0725	ABC transporter, periplasmic molybdate-binding protein
FHP22_RS07895	COG0303	'Molybdopterin
FHP22_RS07900	COG0315	cyclic pyranopterin monophosphate synthase activity
FHP22_RS07900	COG0521	Mo-molybdopterin cofactor biosynthetic process
FHP22_RS07915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FHP22_RS07925	COG0243	molybdopterin cofactor binding
FHP22_RS07930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FHP22_RS07935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FHP22_RS07935	COG2146	nitrite reductase [NAD(P)H] activity
FHP22_RS07940	COG2223	nitrite transmembrane transporter activity
FHP22_RS07950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FHP22_RS07950	COG1116	anion transmembrane transporter activity
FHP22_RS07955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FHP22_RS07965	COG0640	Transcriptional regulator
FHP22_RS07985	COG3122	Protein conserved in bacteria
FHP22_RS07990	COG0668	transmembrane transport
FHP22_RS08000	COG1132	(ABC) transporter
FHP22_RS08020	COG2814	Major facilitator Superfamily
FHP22_RS08045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FHP22_RS08055	COG1113	amino acid transport
FHP22_RS08070	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FHP22_RS08075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHP22_RS08125	COG1525	nuclease
FHP22_RS08135	COG1294	oxidase, subunit
FHP22_RS08140	COG1271	oxidase subunit
FHP22_RS08150	COG2814	Major facilitator Superfamily
FHP22_RS08155	COG2207	Transcriptional regulator
FHP22_RS08160	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS08170	COG1629	transport
FHP22_RS08185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FHP22_RS08190	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FHP22_RS08210	COG0583	DNA-binding transcription factor activity
FHP22_RS08220	COG1346	cytolysis
FHP22_RS08230	COG1283	sodium-dependent phosphate transmembrane transporter activity
FHP22_RS08240	COG0693	protein deglycase activity
FHP22_RS08285	COG0552	protein localization to endoplasmic reticulum
FHP22_RS08290	COG0612	Peptidase, M16
FHP22_RS08320	COG0517	IMP dehydrogenase activity
FHP22_RS08320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FHP22_RS08320	COG0617	tRNA 3'-terminal CCA addition
FHP22_RS08325	COG0133	tryptophan synthase activity
FHP22_RS08335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FHP22_RS08355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FHP22_RS08410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHP22_RS08440	COG0822	iron-sulfur transferase activity
FHP22_RS08445	COG0316	Belongs to the HesB IscA family
FHP22_RS08475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FHP22_RS08490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FHP22_RS08495	COG0702	epimerase
FHP22_RS08500	COG0268	Binds directly to 16S ribosomal RNA
FHP22_RS08520	COG1011	Hydrolase
FHP22_RS08525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FHP22_RS08535	COG2137	regulation of response to DNA damage stimulus
FHP22_RS08550	COG0772	Belongs to the SEDS family
FHP22_RS08565	COG0148	phosphopyruvate hydratase activity
FHP22_RS08595	COG1902	pentaerythritol trinitrate reductase activity
FHP22_RS08595	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHP22_RS08610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FHP22_RS08615	COG2814	Major facilitator Superfamily
FHP22_RS08620	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS08625	COG0583	DNA-binding transcription factor activity
FHP22_RS08630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FHP22_RS08635	COG1027	Aspartate ammonia-lyase
FHP22_RS08650	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FHP22_RS08650	COG0506	proline dehydrogenase activity
FHP22_RS08650	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FHP22_RS08670	COG3698	Phosphodiester glycosidase
FHP22_RS08710	COG0697	spore germination
FHP22_RS08735	COG0424	maF-like protein
FHP22_RS08740	COG2850	peptidyl-arginine hydroxylation
FHP22_RS08745	COG4585	Histidine kinase
FHP22_RS08755	COG0069	glutamate synthase activity
FHP22_RS08775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FHP22_RS08780	COG1454	alcohol dehydrogenase
FHP22_RS08785	COG0824	Thioesterase
FHP22_RS08800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FHP22_RS08805	COG2030	dehydratase
FHP22_RS08815	COG0183	Belongs to the thiolase family
FHP22_RS08830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FHP22_RS08840	COG3135	benzoate transporter
FHP22_RS08850	COG0589	response to stress
FHP22_RS08855	COG0589	response to stress
FHP22_RS08865	COG0308	aminopeptidase N
FHP22_RS08895	COG0786	glutamate:sodium symporter activity
FHP22_RS08950	COG0477	Major facilitator Superfamily
FHP22_RS08965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FHP22_RS08975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FHP22_RS08985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FHP22_RS08990	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS09010	COG3781	membrane
FHP22_RS09015	COG2890	protein-(glutamine-N5) methyltransferase activity
FHP22_RS09020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FHP22_RS09040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHP22_RS09065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FHP22_RS09070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FHP22_RS09075	COG1845	cytochrome c oxidase, subunit III
FHP22_RS09080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FHP22_RS09090	COG0360	Binds together with S18 to 16S ribosomal RNA
FHP22_RS09095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FHP22_RS09110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FHP22_RS09125	COG1305	Transglutaminase-like
FHP22_RS09135	COG2308	Evidence 4 Homologs of previously reported genes of
FHP22_RS09175	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FHP22_RS09180	COG0138	bifunctional purine biosynthesis protein purh
FHP22_RS09200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FHP22_RS09205	COG2011	ABC-type metal ion transport system permease component
FHP22_RS09245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FHP22_RS09255	COG4122	O-methyltransferase activity
FHP22_RS09280	COG2274	protein secretion by the type I secretion system
FHP22_RS09290	COG1137	ATPase activity
FHP22_RS09295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FHP22_RS09305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FHP22_RS09310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FHP22_RS09310	COG0517	IMP dehydrogenase activity
FHP22_RS09335	COG1643	Atp-dependent helicase
FHP22_RS09365	COG3634	alkyl hydroperoxide reductase activity
FHP22_RS09375	COG2391	methyltransferase activity
FHP22_RS09400	COG2070	2-Nitropropane dioxygenase
FHP22_RS09440	COG1278	Cold shock
FHP22_RS09515	COG1309	transcriptional regulator
FHP22_RS09520	COG0596	Alpha beta hydrolase
FHP22_RS09550	COG3328	transposase activity
FHP22_RS09590	COG0352	thiamine-phosphate diphosphorylase activity
FHP22_RS09625	COG0612	Peptidase, M16
FHP22_RS09635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FHP22_RS09645	COG0739	heme binding
FHP22_RS09655	COG1187	pseudouridine synthase activity
FHP22_RS09670	COG1686	Belongs to the peptidase S11 family
FHP22_RS09675	COG1252	NADH dehydrogenase
FHP22_RS09680	COG1047	Peptidyl-prolyl cis-trans
FHP22_RS09705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FHP22_RS09710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FHP22_RS09720	COG0693	protein deglycase activity
FHP22_RS09725	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS09730	COG1301	dicarboxylic acid transport
FHP22_RS09745	COG3139	Protein of unknown function (DUF1315)
FHP22_RS09750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FHP22_RS09755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHP22_RS09790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FHP22_RS09800	COG1720	tRNA m6t6A37 methyltransferase activity
FHP22_RS09820	COG0789	Transcriptional regulator
FHP22_RS09825	COG0431	NADPH-dependent FMN reductase
FHP22_RS09830	COG0798	PFAM Bile acid sodium symporter
FHP22_RS09840	COG0640	Transcriptional regulator
FHP22_RS09850	COG0826	peptidase U32
FHP22_RS09855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FHP22_RS09860	COG3634	alkyl hydroperoxide reductase activity
FHP22_RS09880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FHP22_RS09940	COG1131	(ABC) transporter
FHP22_RS09945	COG0842	Transport permease protein
FHP22_RS09960	COG2951	lytic endotransglycosylase activity
FHP22_RS09985	COG0052	Belongs to the universal ribosomal protein uS2 family
FHP22_RS10005	COG3293	Transposase
FHP22_RS10010	COG2175	clavaminate synthase activity
FHP22_RS10020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FHP22_RS10025	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS10050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FHP22_RS10055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FHP22_RS10060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FHP22_RS10080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FHP22_RS10180	COG1902	pentaerythritol trinitrate reductase activity
FHP22_RS10180	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHP22_RS10195	COG5001	Diguanylate cyclase
FHP22_RS10195	COG4251	negative regulation of phosphorylation
FHP22_RS10195	COG2203	Gaf domain
FHP22_RS10195	COG3706	GGDEF domain
FHP22_RS10200	COG0418	dihydroorotase activity
FHP22_RS10205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FHP22_RS10225	COG0833	amino acid
FHP22_RS10255	COG4172	Belongs to the ABC transporter superfamily
FHP22_RS10260	COG4239	(ABC) transporter, permease
FHP22_RS10265	COG4174	ABC transporter (Permease)
FHP22_RS10270	COG4166	transmembrane transport
FHP22_RS10275	COG0741	lytic transglycosylase activity
FHP22_RS10275	COG1388	LysM domain
FHP22_RS10290	COG2816	NAD+ diphosphatase activity
FHP22_RS10325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FHP22_RS10330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FHP22_RS10340	COG0006	proline dipeptidase activity
FHP22_RS10345	COG3079	Belongs to the UPF0149 family
FHP22_RS10375	COG0277	FAD linked oxidase domain protein
FHP22_RS10385	COG2186	Transcriptional regulator
FHP22_RS10400	COG3328	transposase activity
FHP22_RS10415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FHP22_RS10430	COG2234	aminopeptidase activity
FHP22_RS10440	COG3384	dioxygenase
FHP22_RS10450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FHP22_RS10455	COG2878	Part of a membrane complex involved in electron transport
FHP22_RS10460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FHP22_RS10485	COG0768	penicillin binding
FHP22_RS10490	COG0742	ribosomal rna small subunit methyltransferase
FHP22_RS10505	COG0830	nickel cation binding
FHP22_RS10525	COG0804	urea catabolic process
FHP22_RS10560	COG3015	lipoprotein NlpE involved in copper resistance
FHP22_RS10580	COG1253	flavin adenine dinucleotide binding
FHP22_RS10600	COG3118	belongs to the thioredoxin family
FHP22_RS10630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHP22_RS10635	COG1773	rubredoxin
FHP22_RS10640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FHP22_RS10650	COG0583	DNA-binding transcription factor activity
FHP22_RS10660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHP22_RS10670	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FHP22_RS10675	COG4181	ATPase activity
FHP22_RS10700	COG4771	TonB-dependent receptor
FHP22_RS10740	COG0306	phosphate transporter
FHP22_RS10750	COG2066	Belongs to the glutaminase family
FHP22_RS10760	COG0477	Major facilitator Superfamily
FHP22_RS10790	COG2199	diguanylate cyclase activity
FHP22_RS10790	COG2203	Gaf domain
FHP22_RS10800	COG4681	YaeQ
FHP22_RS10805	COG0523	cobalamin synthesis protein
FHP22_RS10835	COG0583	DNA-binding transcription factor activity
FHP22_RS10840	COG2814	Major facilitator Superfamily
FHP22_RS10850	COG1607	acyl-coa hydrolase
FHP22_RS10860	COG1752	Esterase of the alpha-beta hydrolase superfamily
FHP22_RS10865	COG2059	Chromate
FHP22_RS10870	COG1115	amino acid carrier protein
FHP22_RS10875	COG0786	glutamate:sodium symporter activity
FHP22_RS10890	COG2814	Major facilitator Superfamily
FHP22_RS10895	COG1289	transmembrane transporter activity
FHP22_RS10905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FHP22_RS10960	COG1376	ErfK ybiS ycfS ynhG family protein
FHP22_RS10965	COG2832	Protein of unknown function (DUF454)
FHP22_RS10975	COG5510	response to toxic substance
FHP22_RS10990	COG2198	Histidine kinase
FHP22_RS10990	COG0643	Histidine kinase
FHP22_RS10990	COG0784	Response regulator, receiver
FHP22_RS10995	COG0840	transmembrane signaling receptor activity
FHP22_RS11030	COG0442	prolyl-tRNA aminoacylation
FHP22_RS11065	COG2358	TRAP transporter, solute receptor (TAXI family
FHP22_RS11080	COG0489	protein tyrosine kinase activity
FHP22_RS11085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHP22_RS11085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHP22_RS11110	COG0004	ammonium transporteR
FHP22_RS11125	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FHP22_RS11140	COG2081	HI0933 family
FHP22_RS11150	COG0668	transmembrane transport
FHP22_RS11175	COG0583	DNA-binding transcription factor activity
FHP22_RS11180	COG1278	Cold shock
FHP22_RS11195	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FHP22_RS11200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FHP22_RS11205	COG0713	ATP synthesis coupled electron transport
FHP22_RS11210	COG0839	Belongs to the complex I subunit 6 family
FHP22_RS11215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FHP22_RS11220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FHP22_RS11230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FHP22_RS11250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FHP22_RS11260	COG0142	geranyltranstransferase activity
FHP22_RS11265	COG2828	Protein conserved in bacteria
FHP22_RS11270	COG1113	amino acid transport
FHP22_RS11290	COG0625	glutathione transferase activity
FHP22_RS11330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FHP22_RS11335	COG1530	ribonuclease E activity
FHP22_RS11340	COG0424	maF-like protein
FHP22_RS11345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FHP22_RS11350	COG1792	Involved in formation and maintenance of cell shape
FHP22_RS11355	COG1077	Cell shape determining protein MreB Mrl
FHP22_RS11360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FHP22_RS11370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FHP22_RS11400	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FHP22_RS11415	COG1215	transferase activity, transferring glycosyl groups
FHP22_RS11420	COG0726	polysaccharide deacetylase
FHP22_RS11420	COG1649	PFAM Uncharacterised BCR, COG1649
FHP22_RS11450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FHP22_RS11455	COG2050	protein possibly involved in aromatic compounds catabolism
FHP22_RS11475	COG0420	3'-5' exonuclease activity
FHP22_RS11505	COG0735	belongs to the Fur family
FHP22_RS11510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FHP22_RS11515	COG2914	Belongs to the UPF0125 (RnfH) family
FHP22_RS11565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHP22_RS11575	COG0210	DNA helicase
FHP22_RS11580	COG2885	chlorophyll binding
FHP22_RS11585	COG0204	Acyl-transferase
FHP22_RS11595	COG0850	regulation of cytokinetic process
FHP22_RS11600	COG2894	cell division
FHP22_RS11615	COG1674	ftsk spoiiie
FHP22_RS11615	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FHP22_RS11620	COG0492	ferredoxin-NADP+ reductase activity
FHP22_RS11625	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FHP22_RS11635	COG0456	acetyltransferase
FHP22_RS11660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FHP22_RS11675	COG1981	membrane
FHP22_RS11680	COG1113	amino acid transport
FHP22_RS11685	COG0251	oxidation-reduction process
FHP22_RS11710	COG0352	thiamine-phosphate diphosphorylase activity
FHP22_RS11710	COG0351	phosphomethylpyrimidine kinase
FHP22_RS11710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FHP22_RS11725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FHP22_RS11730	COG2076	Multidrug Resistance protein
FHP22_RS11740	COG2132	Multicopper oxidase
FHP22_RS11750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FHP22_RS11765	COG4269	membrane
FHP22_RS11785	COG1968	undecaprenyl-diphosphatase activity
FHP22_RS11790	COG1214	PFAM Peptidase M22, glycoprotease
FHP22_RS11800	COG0494	nUDIX hydrolase
FHP22_RS11825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FHP22_RS11830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FHP22_RS11890	COG2199	diguanylate cyclase activity
FHP22_RS11920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FHP22_RS11925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FHP22_RS11945	COG0450	alkyl hydroperoxide reductase
FHP22_RS11960	COG0285	dihydrofolate synthase activity
FHP22_RS11965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FHP22_RS12010	COG4206	TonB-dependent receptor
FHP22_RS12015	COG2096	Adenosyltransferase
FHP22_RS12035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FHP22_RS12040	COG2315	Protein conserved in bacteria
FHP22_RS12050	COG1113	amino acid transport
FHP22_RS12060	COG0745	RESPONSE REGULATOR receiver
FHP22_RS12065	COG2205	protein histidine kinase activity
FHP22_RS12075	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS12080	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS12125	COG0675	Transposase, IS605 OrfB family
FHP22_RS12150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FHP22_RS12165	COG1216	Glycosyl transferase, family 2
FHP22_RS12200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FHP22_RS12205	COG5002	protein histidine kinase activity
FHP22_RS12215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FHP22_RS12235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FHP22_RS12250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHP22_RS12285	COG0582	viral genome integration into host DNA
FHP22_RS12295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FHP22_RS12305	COG1704	LemA family
FHP22_RS12320	COG1862	Preprotein translocase
FHP22_RS12345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FHP22_RS12360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FHP22_RS12365	COG5002	protein histidine kinase activity
FHP22_RS12365	COG0784	Response regulator, receiver
FHP22_RS12365	COG2205	protein histidine kinase activity
FHP22_RS12370	COG1024	Enoyl-CoA hydratase
FHP22_RS12380	COG3622	Belongs to the hyi family
FHP22_RS12405	COG0697	spore germination
FHP22_RS12410	COG2814	Major facilitator Superfamily
FHP22_RS12455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FHP22_RS12540	COG1785	Belongs to the alkaline phosphatase family
FHP22_RS12545	COG1785	Belongs to the alkaline phosphatase family
FHP22_RS12555	COG3328	transposase activity
FHP22_RS12580	COG3328	transposase activity
FHP22_RS12615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FHP22_RS12620	COG3385	transposase activity
FHP22_RS12625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FHP22_RS12630	COG0084	hydrolase, TatD family'
FHP22_RS12645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FHP22_RS12660	COG0793	Belongs to the peptidase S41A family
FHP22_RS12690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FHP22_RS12695	COG0280	phosphate acetyltransferase
FHP22_RS12695	COG0857	belongs to the CobB CobQ family
FHP22_RS12720	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FHP22_RS12720	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FHP22_RS12735	COG0740	serine-type endopeptidase activity
FHP22_RS12745	COG4771	TonB-dependent receptor
FHP22_RS12750	COG4774	siderophore transport
FHP22_RS12755	COG3128	pkhd-type hydroxylase
FHP22_RS12765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FHP22_RS12770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHP22_RS12775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHP22_RS12775	COG2813	Specifically methylates the guanine in position
FHP22_RS12840	COG3040	lipid binding
FHP22_RS12870	COG0179	Fumarylacetoacetate (FAA) hydrolase
FHP22_RS12905	COG0557	exoribonuclease II activity
FHP22_RS12910	COG0339	signal peptide processing
FHP22_RS12915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FHP22_RS12945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FHP22_RS12970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FHP22_RS12975	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS12980	COG2072	flavoprotein involved in K transport
FHP22_RS12990	COG0202	RNA polymerase activity
FHP22_RS12995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FHP22_RS13030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FHP22_RS13040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FHP22_RS13045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FHP22_RS13080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FHP22_RS13110	COG0088	Forms part of the polypeptide exit tunnel
FHP22_RS13145	COG1959	2 iron, 2 sulfur cluster binding
FHP22_RS13165	COG1301	dicarboxylic acid transport
FHP22_RS13170	COG1946	Acyl-CoA thioesterase
FHP22_RS13175	COG2937	Belongs to the GPAT DAPAT family
FHP22_RS13185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FHP22_RS13190	COG1040	competence protein
FHP22_RS13205	COG0598	Magnesium transport protein CorA
FHP22_RS13220	COG2854	intermembrane phospholipid transfer
FHP22_RS13225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FHP22_RS13230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FHP22_RS13235	COG1127	ABC transporter
FHP22_RS13260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FHP22_RS13265	COG0408	coproporphyrinogen oxidase activity
FHP22_RS13280	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS13285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FHP22_RS13295	COG0534	Mate efflux family protein
FHP22_RS13300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FHP22_RS13305	COG0254	rRNA binding
FHP22_RS13310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FHP22_RS13330	COG2226	methyltransferase
FHP22_RS13355	COG1192	Involved in chromosome partitioning
FHP22_RS13360	COG0628	permease
FHP22_RS13370	COG2814	Major facilitator Superfamily
FHP22_RS13385	COG0277	FAD linked oxidase domain protein
FHP22_RS13395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FHP22_RS13420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FHP22_RS13425	COG0675	Transposase, IS605 OrfB family
FHP22_RS13430	COG5380	lipid catabolic process
FHP22_RS13435	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FHP22_RS13440	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FHP22_RS13455	COG0335	large ribosomal subunit rRNA binding
FHP22_RS13465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FHP22_RS13470	COG0228	four-way junction DNA binding
FHP22_RS13495	COG0194	GDP metabolic process
FHP22_RS13500	COG1758	RNA polymerase activity
FHP22_RS13505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FHP22_RS13525	COG3307	-O-antigen
FHP22_RS13545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FHP22_RS13550	COG1704	LemA family
FHP22_RS13560	COG0493	'glutamate synthase
FHP22_RS13565	COG0067	glutamate synthase
FHP22_RS13565	COG0069	glutamate synthase activity
FHP22_RS13565	COG0070	glutamate synthase
FHP22_RS13620	COG3385	transposase activity
FHP22_RS13625	COG2226	methyltransferase
FHP22_RS13635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FHP22_RS13640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FHP22_RS13655	COG0275	rRNA processing
FHP22_RS13660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FHP22_RS13670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FHP22_RS13690	COG0488	(ABC) transporter
FHP22_RS13700	COG4221	oxidoreductase activity
FHP22_RS13725	COG0427	acetyl-CoA hydrolase
FHP22_RS13755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FHP22_RS13775	COG0697	spore germination
FHP22_RS13790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FHP22_RS13830	COG3158	transport of potassium into the cell
FHP22_RS13875	COG2826	transposase and inactivated derivatives, IS30 family
FHP22_RS13885	COG2826	transposase and inactivated derivatives, IS30 family
FHP22_RS13915	COG1324	tolerance protein
FHP22_RS13920	COG0673	inositol 2-dehydrogenase activity
FHP22_RS13940	COG2826	transposase and inactivated derivatives, IS30 family
FHP22_RS13975	COG0629	single-stranded DNA binding
FHP22_RS13980	COG2814	Major facilitator Superfamily
FHP22_RS13990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FHP22_RS14005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FHP22_RS14040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FHP22_RS14045	COG3162	membrane
FHP22_RS14050	COG2205	protein histidine kinase activity
FHP22_RS14050	COG0784	Response regulator, receiver
FHP22_RS14070	COG0431	NADPH-dependent FMN reductase
FHP22_RS14085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FHP22_RS14090	COG0668	transmembrane transport
FHP22_RS14095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FHP22_RS14100	COG1519	Transferase
FHP22_RS14105	COG1902	pentaerythritol trinitrate reductase activity
FHP22_RS14130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FHP22_RS14155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FHP22_RS14155	COG0426	domain, Protein
FHP22_RS14160	COG2119	membrane
FHP22_RS14190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FHP22_RS14200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FHP22_RS14210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FHP22_RS14220	COG0189	ligase activity
FHP22_RS14230	COG3328	transposase activity
FHP22_RS14280	COG0708	Exodeoxyribonuclease III
FHP22_RS14285	COG1393	Belongs to the ArsC family
FHP22_RS14300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FHP22_RS14305	COG3706	GGDEF domain
FHP22_RS14310	COG0625	glutathione transferase activity
FHP22_RS14355	COG1247	-acetyltransferase
FHP22_RS14360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FHP22_RS14365	COG4266	Belongs to the allantoicase family
FHP22_RS14370	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FHP22_RS14385	COG0471	metal ion transport
FHP22_RS14425	COG3150	esterase
FHP22_RS14435	COG2918	glutathione biosynthetic process
FHP22_RS14450	COG2733	membrane
FHP22_RS14455	COG0436	Aminotransferase
FHP22_RS14460	COG0534	Mate efflux family protein
FHP22_RS14515	COG0753	catalase activity
FHP22_RS14535	COG3830	Belongs to the UPF0237 family
FHP22_RS14535	COG0560	Phosphoserine phosphatase
FHP22_RS14550	COG0385	Bile acid
FHP22_RS14555	COG1335	isochorismatase
FHP22_RS14560	COG2814	Major facilitator Superfamily
FHP22_RS14565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FHP22_RS14575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FHP22_RS14580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FHP22_RS14585	COG2983	Belongs to the UPF0260 family
FHP22_RS14590	COG5487	UPF0391 membrane protein
FHP22_RS14605	COG1194	a g-specific adenine glycosylase
FHP22_RS14610	COG0739	heme binding
FHP22_RS14620	COG2818	Glycosylase
FHP22_RS14625	COG1064	alcohol dehydrogenase
FHP22_RS14645	COG3023	N-Acetylmuramoyl-L-alanine amidase
FHP22_RS14655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FHP22_RS14660	COG1309	transcriptional regulator
FHP22_RS14670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FHP22_RS14675	COG0546	phosphoglycolate phosphatase activity
FHP22_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
FHP22_RS14700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FHP22_RS14700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FHP22_RS14705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FHP22_RS14710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FHP22_RS14715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHP22_RS14720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHP22_RS14725	COG1116	anion transmembrane transporter activity
FHP22_RS14740	COG1309	transcriptional regulator
FHP22_RS14750	COG0196	riboflavin kinase activity
FHP22_RS14755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FHP22_RS14760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FHP22_RS14765	COG1047	Peptidyl-prolyl cis-trans
FHP22_RS14775	COG2133	pyrroloquinoline quinone binding
FHP22_RS14780	COG2814	Major facilitator Superfamily
FHP22_RS14810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FHP22_RS14820	COG0657	acetylesterase activity
FHP22_RS14855	COG2951	lytic endotransglycosylase activity
FHP22_RS14865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FHP22_RS14885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FHP22_RS14905	COG2388	GCN5-related N-acetyl-transferase
FHP22_RS14915	COG0861	Integral membrane protein TerC family
FHP22_RS14920	COG0402	S-adenosylhomocysteine deaminase activity
FHP22_RS14935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FHP22_RS14940	COG1230	cation diffusion facilitator family transporter
FHP22_RS14975	COG0706	membrane insertase activity
FHP22_RS14980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FHP22_RS14985	COG0594	ribonuclease P activity
FHP22_RS15000	COG2026	Addiction module toxin, RelE StbE family
FHP22_RS15020	COG0582	viral genome integration into host DNA
FHP22_RS15040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHP22_RS15095	COG1660	Displays ATPase and GTPase activities
FHP22_RS15120	COG0488	(ABC) transporter
FHP22_RS15130	COG0488	(ABC) transporter
FHP22_RS15135	COG0488	(ABC) transporter
FHP22_RS15140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FHP22_RS15215	COG1373	ATPase (AAA superfamily
FHP22_RS15285	COG4974	Belongs to the 'phage' integrase family
FHP22_RS15310	COG2184	nucleotidyltransferase activity
FHP22_RS15330	COG3328	transposase activity
FHP22_RS15360	COG1192	Involved in chromosome partitioning
FHP22_RS15380	COG2963	transposase activity
FHP22_RS15400	COG1414	Transcriptional regulator
FHP22_RS15405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FHP22_RS15410	COG1414	Transcriptional regulator
FHP22_RS15415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FHP22_RS15420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FHP22_RS15425	COG0183	Belongs to the thiolase family
FHP22_RS15430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FHP22_RS15435	COG0596	Alpha beta hydrolase
FHP22_RS15440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FHP22_RS15445	COG3485	protocatechuate 3,4-dioxygenase
FHP22_RS15450	COG3485	protocatechuate 3,4-dioxygenase
FHP22_RS15485	COG2801	Transposase and inactivated derivatives
FHP22_RS15500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FHP22_RS15515	COG2814	Major facilitator Superfamily
FHP22_RS15520	COG1024	Enoyl-CoA hydratase
FHP22_RS15525	COG1012	belongs to the aldehyde dehydrogenase family
FHP22_RS15530	COG1022	Amp-dependent synthetase and ligase
FHP22_RS15530	COG3320	Male sterility
FHP22_RS15535	COG1960	acyl-CoA dehydrogenase activity
FHP22_RS15575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHP22_RS15750	COG1192	Involved in chromosome partitioning
FHP22_RS15795	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system