locus-tag	class	description
GA721_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GA721_RS00010	COG0592	DNA-directed DNA polymerase activity
GA721_RS00020	COG0187	DNA topoisomerase II activity
GA721_RS00025	COG1063	alcohol dehydrogenase
GA721_RS00045	COG0488	(ABC) transporter
GA721_RS00070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GA721_RS00075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GA721_RS00085	COG0737	Belongs to the 5'-nucleotidase family
GA721_RS00115	COG2814	Major facilitator Superfamily
GA721_RS00120	COG2133	pyrroloquinoline quinone binding
GA721_RS00130	COG1047	Peptidyl-prolyl cis-trans
GA721_RS00135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GA721_RS00140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GA721_RS00145	COG0196	riboflavin kinase activity
GA721_RS00160	COG1309	transcriptional regulator
GA721_RS00165	COG1116	anion transmembrane transporter activity
GA721_RS00170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GA721_RS00175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA721_RS00180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GA721_RS00185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GA721_RS00190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GA721_RS00190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GA721_RS00210	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS00215	COG0546	phosphoglycolate phosphatase activity
GA721_RS00220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GA721_RS00230	COG1309	transcriptional regulator
GA721_RS00235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GA721_RS00245	COG3023	N-Acetylmuramoyl-L-alanine amidase
GA721_RS00265	COG1064	alcohol dehydrogenase
GA721_RS00270	COG2818	Glycosylase
GA721_RS00280	COG0739	heme binding
GA721_RS00285	COG1194	a g-specific adenine glycosylase
GA721_RS00300	COG5487	UPF0391 membrane protein
GA721_RS00305	COG2983	Belongs to the UPF0260 family
GA721_RS00310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GA721_RS00315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GA721_RS00325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GA721_RS00330	COG2814	Major facilitator Superfamily
GA721_RS00335	COG1335	isochorismatase
GA721_RS00340	COG0385	Bile acid
GA721_RS00355	COG0560	Phosphoserine phosphatase
GA721_RS00355	COG3830	Belongs to the UPF0237 family
GA721_RS00375	COG0753	catalase activity
GA721_RS00420	COG0534	Mate efflux family protein
GA721_RS00425	COG0436	Aminotransferase
GA721_RS00430	COG2733	membrane
GA721_RS00445	COG2918	glutathione biosynthetic process
GA721_RS00450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GA721_RS00460	COG3150	esterase
GA721_RS00475	COG0559	Belongs to the binding-protein-dependent transport system permease family
GA721_RS00490	COG0410	ABC transporter
GA721_RS00500	COG0471	metal ion transport
GA721_RS00510	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GA721_RS00515	COG4266	Belongs to the allantoicase family
GA721_RS00520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GA721_RS00525	COG1247	-acetyltransferase
GA721_RS00565	COG0625	glutathione transferase activity
GA721_RS00570	COG3706	GGDEF domain
GA721_RS00575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GA721_RS00590	COG1393	Belongs to the ArsC family
GA721_RS00595	COG0708	Exodeoxyribonuclease III
GA721_RS00615	COG0189	ligase activity
GA721_RS00620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GA721_RS00625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GA721_RS00635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GA721_RS00645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GA721_RS00675	COG2119	membrane
GA721_RS00680	COG0426	domain, Protein
GA721_RS00680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GA721_RS00705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GA721_RS00730	COG1902	pentaerythritol trinitrate reductase activity
GA721_RS00735	COG1519	Transferase
GA721_RS00740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GA721_RS00745	COG0668	transmembrane transport
GA721_RS00750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GA721_RS00760	COG0431	NADPH-dependent FMN reductase
GA721_RS00775	COG2205	protein histidine kinase activity
GA721_RS00775	COG0784	Response regulator, receiver
GA721_RS00780	COG3162	membrane
GA721_RS00785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA721_RS00805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GA721_RS00815	COG3706	GGDEF domain
GA721_RS00820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GA721_RS00825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GA721_RS00835	COG2814	Major facilitator Superfamily
GA721_RS00890	COG2132	Multicopper oxidase
GA721_RS00905	COG2205	protein histidine kinase activity
GA721_RS00910	COG3174	membrane
GA721_RS00915	COG2217	Heavy metal translocating P-type atpase
GA721_RS00965	COG2132	Multicopper oxidase
GA721_RS00975	COG2801	Transposase and inactivated derivatives
GA721_RS00980	COG3077	Addiction module antitoxin, RelB DinJ family
GA721_RS01000	COG0450	alkyl hydroperoxide reductase
GA721_RS01010	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GA721_RS01035	COG3158	transport of potassium into the cell
GA721_RS01055	COG1943	Transposase
GA721_RS01080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GA721_RS01095	COG0697	spore germination
GA721_RS01115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GA721_RS01145	COG0427	acetyl-CoA hydrolase
GA721_RS01150	COG2205	protein histidine kinase activity
GA721_RS01155	COG0745	RESPONSE REGULATOR receiver
GA721_RS01175	COG4221	oxidoreductase activity
GA721_RS01185	COG0488	(ABC) transporter
GA721_RS01190	COG1943	Transposase
GA721_RS01215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GA721_RS01225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GA721_RS01230	COG0275	rRNA processing
GA721_RS01245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GA721_RS01250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GA721_RS01260	COG2226	methyltransferase
GA721_RS01310	COG0069	glutamate synthase activity
GA721_RS01310	COG0067	glutamate synthase
GA721_RS01310	COG0070	glutamate synthase
GA721_RS01315	COG0493	'glutamate synthase
GA721_RS01330	COG1704	LemA family
GA721_RS01335	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GA721_RS01355	COG3307	-O-antigen
GA721_RS01370	COG2906	2 iron, 2 sulfur cluster binding
GA721_RS01380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GA721_RS01385	COG1758	RNA polymerase activity
GA721_RS01390	COG0194	GDP metabolic process
GA721_RS01435	COG0228	four-way junction DNA binding
GA721_RS01440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GA721_RS01450	COG0335	large ribosomal subunit rRNA binding
GA721_RS01465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GA721_RS01470	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GA721_RS01475	COG5380	lipid catabolic process
GA721_RS01480	COG0675	Transposase, IS605 OrfB family
GA721_RS01485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GA721_RS01505	COG5006	permease, DMT superfamily
GA721_RS01510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GA721_RS01520	COG0277	FAD linked oxidase domain protein
GA721_RS01535	COG2814	Major facilitator Superfamily
GA721_RS01545	COG0628	permease
GA721_RS01550	COG1192	Involved in chromosome partitioning
GA721_RS01570	COG1943	Transposase
GA721_RS01575	COG2226	methyltransferase
GA721_RS01610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GA721_RS01620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GA721_RS01625	COG0534	Mate efflux family protein
GA721_RS01635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GA721_RS01645	COG1960	acyl-CoA dehydrogenase activity
GA721_RS01665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GA721_RS01690	COG1127	ABC transporter
GA721_RS01695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GA721_RS01700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GA721_RS01705	COG2854	intermembrane phospholipid transfer
GA721_RS01715	COG0598	Magnesium transport protein CorA
GA721_RS01730	COG1040	competence protein
GA721_RS01735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GA721_RS01745	COG2937	Belongs to the GPAT DAPAT family
GA721_RS01750	COG1946	Acyl-CoA thioesterase
GA721_RS01755	COG1301	dicarboxylic acid transport
GA721_RS01775	COG1959	2 iron, 2 sulfur cluster binding
GA721_RS01780	COG1017	nitric oxide dioxygenase activity
GA721_RS01780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GA721_RS01785	COG0433	COG0433 Predicted ATPase
GA721_RS01810	COG0088	Forms part of the polypeptide exit tunnel
GA721_RS01840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GA721_RS01865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GA721_RS01875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GA721_RS01880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GA721_RS01890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GA721_RS01910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GA721_RS01920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GA721_RS01925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GA721_RS01930	COG0202	RNA polymerase activity
GA721_RS01940	COG2072	flavoprotein involved in K transport
GA721_RS01945	COG1960	acyl-CoA dehydrogenase activity
GA721_RS01950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GA721_RS01975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GA721_RS02000	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GA721_RS02005	COG0339	signal peptide processing
GA721_RS02010	COG0557	exoribonuclease II activity
GA721_RS02045	COG0179	Fumarylacetoacetate (FAA) hydrolase
GA721_RS02075	COG3040	lipid binding
GA721_RS02135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA721_RS02135	COG2813	Specifically methylates the guanine in position
GA721_RS02140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA721_RS02145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GA721_RS02155	COG3128	pkhd-type hydroxylase
GA721_RS02160	COG4774	siderophore transport
GA721_RS02165	COG4771	TonB-dependent receptor
GA721_RS02175	COG0740	serine-type endopeptidase activity
GA721_RS02190	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GA721_RS02190	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GA721_RS02200	COG0280	phosphate acetyltransferase
GA721_RS02200	COG0857	belongs to the CobB CobQ family
GA721_RS02205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GA721_RS02220	COG0596	Alpha beta hydrolase
GA721_RS02220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA721_RS02220	COG2226	methyltransferase
GA721_RS02235	COG0793	Belongs to the peptidase S41A family
GA721_RS02250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GA721_RS02265	COG0084	hydrolase, TatD family'
GA721_RS02270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GA721_RS02275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GA721_RS02295	COG1058	Belongs to the CinA family
GA721_RS02295	COG1546	Belongs to the CinA family
GA721_RS02315	COG2814	Major facilitator Superfamily
GA721_RS02320	COG0697	spore germination
GA721_RS02325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GA721_RS02330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GA721_RS02335	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GA721_RS02345	COG3622	Belongs to the hyi family
GA721_RS02355	COG1024	Enoyl-CoA hydratase
GA721_RS02360	COG5002	protein histidine kinase activity
GA721_RS02360	COG2205	protein histidine kinase activity
GA721_RS02360	COG0784	Response regulator, receiver
GA721_RS02365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GA721_RS02380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GA721_RS02400	COG1862	Preprotein translocase
GA721_RS02410	COG3706	GGDEF domain
GA721_RS02410	COG4251	negative regulation of phosphorylation
GA721_RS02410	COG5001	Diguanylate cyclase
GA721_RS02410	COG2203	Gaf domain
GA721_RS02415	COG1704	LemA family
GA721_RS02425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GA721_RS02440	COG5002	protein histidine kinase activity
GA721_RS02445	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GA721_RS02495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GA721_RS02525	COG3223	Belongs to the PsiE family
GA721_RS02530	COG1960	acyl-CoA dehydrogenase activity
GA721_RS02535	COG1960	acyl-CoA dehydrogenase activity
GA721_RS02545	COG2205	protein histidine kinase activity
GA721_RS02550	COG0745	RESPONSE REGULATOR receiver
GA721_RS02560	COG2315	Protein conserved in bacteria
GA721_RS02565	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GA721_RS02585	COG2096	Adenosyltransferase
GA721_RS02590	COG4206	TonB-dependent receptor
GA721_RS02600	COG0133	tryptophan synthase activity
GA721_RS02635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GA721_RS02640	COG0285	dihydrofolate synthase activity
GA721_RS02655	COG0450	alkyl hydroperoxide reductase
GA721_RS02670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GA721_RS02675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GA721_RS02770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GA721_RS02775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GA721_RS02825	COG0494	nUDIX hydrolase
GA721_RS02835	COG1214	PFAM Peptidase M22, glycoprotease
GA721_RS02840	COG1968	undecaprenyl-diphosphatase activity
GA721_RS02860	COG4269	membrane
GA721_RS02875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GA721_RS02885	COG2132	Multicopper oxidase
GA721_RS02895	COG2076	Multidrug Resistance protein
GA721_RS02910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GA721_RS02925	COG0352	thiamine-phosphate diphosphorylase activity
GA721_RS02925	COG0351	phosphomethylpyrimidine kinase
GA721_RS02925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GA721_RS02935	COG1522	sequence-specific DNA binding
GA721_RS02950	COG0251	oxidation-reduction process
GA721_RS02955	COG1113	amino acid transport
GA721_RS02975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GA721_RS03000	COG0456	acetyltransferase
GA721_RS03010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GA721_RS03015	COG0492	ferredoxin-NADP+ reductase activity
GA721_RS03020	COG1674	ftsk spoiiie
GA721_RS03020	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GA721_RS03035	COG2894	cell division
GA721_RS03040	COG0850	regulation of cytokinetic process
GA721_RS03050	COG0204	Acyl-transferase
GA721_RS03055	COG2885	chlorophyll binding
GA721_RS03065	COG0210	DNA helicase
GA721_RS03070	COG0756	dUTP diphosphatase activity
GA721_RS03075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GA721_RS03090	COG0121	glutamine amidotransferase
GA721_RS03105	COG2914	Belongs to the UPF0125 (RnfH) family
GA721_RS03110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GA721_RS03115	COG0735	belongs to the Fur family
GA721_RS03145	COG0420	3'-5' exonuclease activity
GA721_RS03165	COG2050	protein possibly involved in aromatic compounds catabolism
GA721_RS03170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GA721_RS03215	COG3328	transposase activity
GA721_RS03225	COG0726	polysaccharide deacetylase
GA721_RS03225	COG1649	PFAM Uncharacterised BCR, COG1649
GA721_RS03230	COG1215	transferase activity, transferring glycosyl groups
GA721_RS03245	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GA721_RS03275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GA721_RS03280	COG0154	amidase activity
GA721_RS03285	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GA721_RS03290	COG1077	Cell shape determining protein MreB Mrl
GA721_RS03295	COG1792	Involved in formation and maintenance of cell shape
GA721_RS03300	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GA721_RS03305	COG0424	maF-like protein
GA721_RS03310	COG1530	ribonuclease E activity
GA721_RS03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GA721_RS03360	COG0625	glutathione transferase activity
GA721_RS03370	COG0675	Transposase, IS605 OrfB family
GA721_RS03385	COG1113	amino acid transport
GA721_RS03390	COG2828	Protein conserved in bacteria
GA721_RS03395	COG0142	geranyltranstransferase activity
GA721_RS03405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GA721_RS03425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GA721_RS03435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GA721_RS03440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GA721_RS03445	COG0839	Belongs to the complex I subunit 6 family
GA721_RS03450	COG0713	ATP synthesis coupled electron transport
GA721_RS03455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GA721_RS03460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GA721_RS03475	COG1278	Cold shock
GA721_RS03480	COG1278	Cold shock
GA721_RS03485	COG0583	DNA-binding transcription factor activity
GA721_RS03510	COG0668	transmembrane transport
GA721_RS03520	COG2081	HI0933 family
GA721_RS03540	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GA721_RS03555	COG0004	ammonium transporteR
GA721_RS03580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA721_RS03580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA721_RS03585	COG0489	protein tyrosine kinase activity
GA721_RS03635	COG0442	prolyl-tRNA aminoacylation
GA721_RS03670	COG0840	transmembrane signaling receptor activity
GA721_RS03690	COG5510	response to toxic substance
GA721_RS03700	COG2832	Protein of unknown function (DUF454)
GA721_RS03705	COG1376	ErfK ybiS ycfS ynhG family protein
GA721_RS03760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GA721_RS03770	COG1289	transmembrane transporter activity
GA721_RS03775	COG2814	Major facilitator Superfamily
GA721_RS03790	COG0786	glutamate:sodium symporter activity
GA721_RS03795	COG1115	amino acid carrier protein
GA721_RS03800	COG2059	Chromate
GA721_RS03805	COG1752	Esterase of the alpha-beta hydrolase superfamily
GA721_RS03815	COG1607	acyl-coa hydrolase
GA721_RS03820	COG1309	transcriptional regulator
GA721_RS03825	COG2814	Major facilitator Superfamily
GA721_RS03830	COG0583	DNA-binding transcription factor activity
GA721_RS03835	COG0625	glutathione transferase activity
GA721_RS03850	COG0523	cobalamin synthesis protein
GA721_RS03855	COG4681	YaeQ
GA721_RS03865	COG2199	diguanylate cyclase activity
GA721_RS03865	COG2203	Gaf domain
GA721_RS03920	COG2066	Belongs to the glutaminase family
GA721_RS03940	COG0306	phosphate transporter
GA721_RS03965	COG4771	TonB-dependent receptor
GA721_RS03970	COG0500	methyltransferase
GA721_RS03995	COG4181	ATPase activity
GA721_RS04000	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GA721_RS04010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GA721_RS04020	COG0583	DNA-binding transcription factor activity
GA721_RS04030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA721_RS04035	COG1773	rubredoxin
GA721_RS04040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GA721_RS04060	COG0175	sulfate reduction
GA721_RS04075	COG3118	belongs to the thioredoxin family
GA721_RS04095	COG1253	flavin adenine dinucleotide binding
GA721_RS04115	COG3015	lipoprotein NlpE involved in copper resistance
GA721_RS04120	COG0204	Acyl-transferase
GA721_RS04130	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS04150	COG0804	urea catabolic process
GA721_RS04170	COG0830	nickel cation binding
GA721_RS04185	COG0742	ribosomal rna small subunit methyltransferase
GA721_RS04190	COG0768	penicillin binding
GA721_RS04215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GA721_RS04220	COG2878	Part of a membrane complex involved in electron transport
GA721_RS04225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GA721_RS04235	COG3384	dioxygenase
GA721_RS04245	COG2234	aminopeptidase activity
GA721_RS04255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GA721_RS04275	COG2186	Transcriptional regulator
GA721_RS04285	COG0277	FAD linked oxidase domain protein
GA721_RS04330	COG3079	Belongs to the UPF0149 family
GA721_RS04335	COG0006	proline dipeptidase activity
GA721_RS04340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GA721_RS04345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GA721_RS04380	COG2816	NAD+ diphosphatase activity
GA721_RS04395	COG1388	LysM domain
GA721_RS04395	COG0741	lytic transglycosylase activity
GA721_RS04400	COG4166	transmembrane transport
GA721_RS04405	COG4174	ABC transporter (Permease)
GA721_RS04410	COG4239	(ABC) transporter, permease
GA721_RS04415	COG4172	Belongs to the ABC transporter superfamily
GA721_RS04465	COG0833	amino acid
GA721_RS04485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GA721_RS04490	COG0418	dihydroorotase activity
GA721_RS04495	COG5001	Diguanylate cyclase
GA721_RS04495	COG4251	negative regulation of phosphorylation
GA721_RS04495	COG2203	Gaf domain
GA721_RS04495	COG3706	GGDEF domain
GA721_RS04515	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA721_RS04515	COG1902	pentaerythritol trinitrate reductase activity
GA721_RS04540	COG3293	Transposase
GA721_RS04560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GA721_RS04560	COG2885	chlorophyll binding
GA721_RS04600	COG2871	sodium ion transport
GA721_RS04630	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GA721_RS04650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GA721_RS04655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GA721_RS04660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GA721_RS04670	COG1473	amidohydrolase
GA721_RS04690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GA721_RS04700	COG2175	clavaminate synthase activity
GA721_RS04715	COG0024	Methionine aminopeptidase
GA721_RS04720	COG0052	Belongs to the universal ribosomal protein uS2 family
GA721_RS04745	COG2951	lytic endotransglycosylase activity
GA721_RS04760	COG0842	Transport permease protein
GA721_RS04765	COG1131	(ABC) transporter
GA721_RS04820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GA721_RS04840	COG3634	alkyl hydroperoxide reductase activity
GA721_RS04845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GA721_RS04860	COG0640	Transcriptional regulator
GA721_RS04870	COG0798	PFAM Bile acid sodium symporter
GA721_RS04875	COG0431	NADPH-dependent FMN reductase
GA721_RS04880	COG0789	Transcriptional regulator
GA721_RS04905	COG1720	tRNA m6t6A37 methyltransferase activity
GA721_RS04915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GA721_RS04925	COG0745	RESPONSE REGULATOR receiver
GA721_RS04930	COG0642	Histidine kinase
GA721_RS04950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GA721_RS04955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GA721_RS04960	COG3139	Protein of unknown function (DUF1315)
GA721_RS04975	COG1960	acyl-CoA dehydrogenase activity
GA721_RS04985	COG0693	protein deglycase activity
GA721_RS04995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GA721_RS05000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GA721_RS05025	COG1047	Peptidyl-prolyl cis-trans
GA721_RS05030	COG1252	NADH dehydrogenase
GA721_RS05035	COG1686	Belongs to the peptidase S11 family
GA721_RS05050	COG1187	pseudouridine synthase activity
GA721_RS05060	COG0739	heme binding
GA721_RS05070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GA721_RS05080	COG0612	Peptidase, M16
GA721_RS05115	COG0352	thiamine-phosphate diphosphorylase activity
GA721_RS05165	COG0596	Alpha beta hydrolase
GA721_RS05170	COG1309	transcriptional regulator
GA721_RS05235	COG1278	Cold shock
GA721_RS05255	COG2070	2-Nitropropane dioxygenase
GA721_RS05280	COG2391	methyltransferase activity
GA721_RS05285	COG3293	Transposase
GA721_RS05295	COG3634	alkyl hydroperoxide reductase activity
GA721_RS05320	COG0450	alkyl hydroperoxide reductase
GA721_RS05325	COG1643	Atp-dependent helicase
GA721_RS05350	COG0517	IMP dehydrogenase activity
GA721_RS05350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GA721_RS05355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GA721_RS05365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GA721_RS05370	COG1137	ATPase activity
GA721_RS05405	COG4122	O-methyltransferase activity
GA721_RS05415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GA721_RS05430	COG1454	alcohol dehydrogenase
GA721_RS05465	COG2011	ABC-type metal ion transport system permease component
GA721_RS05470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GA721_RS05490	COG0138	bifunctional purine biosynthesis protein purh
GA721_RS05495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GA721_RS05535	COG2308	Evidence 4 Homologs of previously reported genes of
GA721_RS05545	COG1305	Transglutaminase-like
GA721_RS05560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GA721_RS05565	COG0305	Participates in initiation and elongation during chromosome replication
GA721_RS05575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GA721_RS05580	COG0360	Binds together with S18 to 16S ribosomal RNA
GA721_RS05590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GA721_RS05595	COG1845	cytochrome c oxidase, subunit III
GA721_RS05600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GA721_RS05605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GA721_RS05630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA721_RS05645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GA721_RS05655	COG3781	membrane
GA721_RS05675	COG1960	acyl-CoA dehydrogenase activity
GA721_RS05680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GA721_RS05695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GA721_RS05705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GA721_RS05715	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GA721_RS05720	COG0477	Major facilitator Superfamily
GA721_RS05785	COG0308	aminopeptidase N
GA721_RS05795	COG0589	response to stress
GA721_RS05800	COG0589	response to stress
GA721_RS05810	COG3135	benzoate transporter
GA721_RS05820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GA721_RS05835	COG0183	Belongs to the thiolase family
GA721_RS05860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GA721_RS05865	COG0824	Thioesterase
GA721_RS05870	COG1454	alcohol dehydrogenase
GA721_RS05875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GA721_RS05895	COG0069	glutamate synthase activity
GA721_RS05905	COG4585	Histidine kinase
GA721_RS05910	COG2850	peptidyl-arginine hydroxylation
GA721_RS05920	COG0424	maF-like protein
GA721_RS05945	COG0697	spore germination
GA721_RS05985	COG3698	Phosphodiester glycosidase
GA721_RS06005	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GA721_RS06005	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GA721_RS06005	COG0506	proline dehydrogenase activity
GA721_RS06015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA721_RS06020	COG1027	Aspartate ammonia-lyase
GA721_RS06025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GA721_RS06035	COG1960	acyl-CoA dehydrogenase activity
GA721_RS06055	COG1902	pentaerythritol trinitrate reductase activity
GA721_RS06055	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA721_RS06085	COG0148	phosphopyruvate hydratase activity
GA721_RS06100	COG0772	Belongs to the SEDS family
GA721_RS06115	COG2137	regulation of response to DNA damage stimulus
GA721_RS06125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GA721_RS06130	COG1011	Hydrolase
GA721_RS06135	COG1218	3'(2'),5'-bisphosphate nucleotidase
GA721_RS06150	COG0268	Binds directly to 16S ribosomal RNA
GA721_RS06155	COG0702	epimerase
GA721_RS06160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GA721_RS06175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GA721_RS06205	COG0316	Belongs to the HesB IscA family
GA721_RS06210	COG0822	iron-sulfur transferase activity
GA721_RS06240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GA721_RS06300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GA721_RS06320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GA721_RS06330	COG0133	tryptophan synthase activity
GA721_RS06335	COG0517	IMP dehydrogenase activity
GA721_RS06335	COG0516	GMP reductase activity
GA721_RS06365	COG0612	Peptidase, M16
GA721_RS06370	COG0552	protein localization to endoplasmic reticulum
GA721_RS06415	COG0693	protein deglycase activity
GA721_RS06425	COG1283	sodium-dependent phosphate transmembrane transporter activity
GA721_RS06435	COG1346	cytolysis
GA721_RS06445	COG0583	DNA-binding transcription factor activity
GA721_RS06470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GA721_RS06485	COG1629	transport
GA721_RS06500	COG1960	acyl-CoA dehydrogenase activity
GA721_RS06505	COG2207	Transcriptional regulator
GA721_RS06510	COG2814	Major facilitator Superfamily
GA721_RS06525	COG1294	oxidase, subunit
GA721_RS06535	COG1525	nuclease
GA721_RS06585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GA721_RS06590	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GA721_RS06605	COG1113	amino acid transport
GA721_RS06615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GA721_RS06625	COG2814	Major facilitator Superfamily
GA721_RS06645	COG1132	(ABC) transporter
GA721_RS06660	COG0668	transmembrane transport
GA721_RS06665	COG3122	Protein conserved in bacteria
GA721_RS06685	COG0640	Transcriptional regulator
GA721_RS06690	COG2937	Belongs to the GPAT DAPAT family
GA721_RS06695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GA721_RS06700	COG1116	anion transmembrane transporter activity
GA721_RS06700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GA721_RS06710	COG2223	nitrite transmembrane transporter activity
GA721_RS06715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA721_RS06720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA721_RS06725	COG0243	molybdopterin cofactor binding
GA721_RS06735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GA721_RS06750	COG0315	cyclic pyranopterin monophosphate synthase activity
GA721_RS06750	COG0521	Mo-molybdopterin cofactor biosynthetic process
GA721_RS06755	COG0303	'Molybdopterin
GA721_RS06765	COG4149	molybdate abc transporter
GA721_RS06770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GA721_RS06775	COG0583	DNA-binding transcription factor activity
GA721_RS06795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA721_RS06800	COG0183	Belongs to the thiolase family
GA721_RS06805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GA721_RS06810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GA721_RS06815	COG3135	benzoate transporter
GA721_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS06825	COG0543	2 iron, 2 sulfur cluster binding
GA721_RS06825	COG0633	Ferredoxin
GA721_RS06830	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GA721_RS06835	COG4638	Rieske (2fe-2S)
GA721_RS06845	COG4829	muconolactone delta-isomerase
GA721_RS06850	COG4948	Mandelate Racemase Muconate Lactonizing
GA721_RS06855	COG0583	DNA-binding transcription factor activity
GA721_RS06860	COG2814	Major facilitator Superfamily
GA721_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS06900	COG2223	nitrite transmembrane transporter activity
GA721_RS06910	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GA721_RS06915	COG2116	formate transmembrane transporter activity
GA721_RS06920	COG0515	serine threonine protein kinase
GA721_RS06950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA721_RS06985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GA721_RS06990	COG1309	transcriptional regulator
GA721_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
GA721_RS07015	COG0745	RESPONSE REGULATOR receiver
GA721_RS07025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GA721_RS07040	COG2885	chlorophyll binding
GA721_RS07050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GA721_RS07055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GA721_RS07060	COG0730	response to heat
GA721_RS07070	COG2801	Transposase and inactivated derivatives
GA721_RS07160	COG0596	Alpha beta hydrolase
GA721_RS07195	COG0511	ligase activity, forming carbon-carbon bonds
GA721_RS07200	COG0439	Biotin carboxylase
GA721_RS07215	COG2814	Major facilitator Superfamily
GA721_RS07220	COG3038	cytochrome b561
GA721_RS07250	COG1546	Belongs to the CinA family
GA721_RS07250	COG1058	Belongs to the CinA family
GA721_RS07260	COG0372	Belongs to the citrate synthase family
GA721_RS07295	COG0542	response to heat
GA721_RS07300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GA721_RS07325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GA721_RS07335	COG0569	domain protein
GA721_RS07340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GA721_RS07360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GA721_RS07370	COG1585	Membrane protein implicated in regulation of membrane protease activity
GA721_RS07385	COG1294	oxidase, subunit
GA721_RS07390	COG4890	Cyd operon protein YbgT
GA721_RS07425	COG1960	acyl-CoA dehydrogenase activity
GA721_RS07430	COG1960	acyl-CoA dehydrogenase activity
GA721_RS07440	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GA721_RS07445	COG2207	Transcriptional regulator
GA721_RS07450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GA721_RS07455	COG0730	response to heat
GA721_RS07460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GA721_RS07490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GA721_RS07510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GA721_RS07525	COG0575	Belongs to the CDS family
GA721_RS07530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GA721_RS07535	COG0233	cytoplasmic translational termination
GA721_RS07550	COG3852	Histidine kinase
GA721_RS07565	COG0583	DNA-binding transcription factor activity
GA721_RS07570	COG0024	Methionine aminopeptidase
GA721_RS07600	COG1253	flavin adenine dinucleotide binding
GA721_RS07620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GA721_RS07625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GA721_RS07640	COG2431	L-lysine efflux transmembrane transporter activity
GA721_RS07645	COG0284	orotidine-5'-phosphate decarboxylase activity
GA721_RS07655	COG0776	regulation of translation
GA721_RS07675	COG0590	tRNA wobble adenosine to inosine editing
GA721_RS07685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GA721_RS07720	COG0084	hydrolase, TatD family'
GA721_RS07740	COG1663	tetraacyldisaccharide 4'-kinase activity
GA721_RS07745	COG1132	(ABC) transporter
GA721_RS07755	COG0811	peptide transport
GA721_RS07760	COG1475	DNA binding
GA721_RS07765	COG1192	Involved in chromosome partitioning
GA721_RS07775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GA721_RS07780	COG3178	'Phosphotransferase
GA721_RS07790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GA721_RS07795	COG1923	regulation of RNA biosynthetic process
GA721_RS07805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GA721_RS07810	COG0802	atpase or kinase
GA721_RS07835	COG2707	UPF0756 membrane protein
GA721_RS07845	COG0583	DNA-binding transcription factor activity
GA721_RS07850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GA721_RS07880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GA721_RS07880	COG0519	Catalyzes the synthesis of GMP from XMP
GA721_RS07885	COG2353	YceI-like domain
GA721_RS07895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GA721_RS07900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GA721_RS07935	COG1254	Belongs to the acylphosphatase family
GA721_RS07940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GA721_RS07940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GA721_RS07945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GA721_RS07965	COG0318	PFAM AMP-dependent synthetase and ligase
GA721_RS07970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GA721_RS07975	COG3327	negative regulation of DNA-templated transcription, initiation
GA721_RS07980	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GA721_RS07985	COG0183	Belongs to the thiolase family
GA721_RS07990	COG1250	3-hydroxyacyl-CoA dehydrogenase
GA721_RS07995	COG1024	Enoyl-CoA hydratase
GA721_RS08000	COG1024	Enoyl-CoA hydratase
GA721_RS08005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GA721_RS08010	COG2151	metal-sulfur cluster biosynthetic enzyme
GA721_RS08015	COG3396	Phenylacetate-CoA oxygenase
GA721_RS08020	COG3460	Phenylacetate-CoA oxygenase
GA721_RS08025	COG3396	Phenylacetate-CoA oxygenase
GA721_RS08030	COG1012	belongs to the aldehyde dehydrogenase family
GA721_RS08030	COG2030	dehydratase
GA721_RS08035	COG2814	Major facilitator Superfamily
GA721_RS08040	COG0783	Belongs to the Dps family
GA721_RS08095	COG2963	transposase activity
GA721_RS08155	COG0642	Histidine kinase
GA721_RS08170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GA721_RS08200	COG3046	protein related to deoxyribodipyrimidine photolyase
GA721_RS08215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GA721_RS08225	COG1136	(ABC) transporter
GA721_RS08230	COG4591	ABC-type transport system involved in lipoprotein release permease component
GA721_RS08235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA721_RS08255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GA721_RS08290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GA721_RS08315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GA721_RS08350	COG3615	Tellurite resistance protein tehB
GA721_RS08350	COG0500	methyltransferase
GA721_RS08375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GA721_RS08505	COG0582	viral genome integration into host DNA
GA721_RS08545	COG0012	GTP binding
GA721_RS08555	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GA721_RS08570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GA721_RS08580	COG0386	Belongs to the glutathione peroxidase family
GA721_RS08585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GA721_RS08590	COG0436	Aminotransferase
GA721_RS08595	COG2755	lipolytic protein G-D-S-L family
GA721_RS08595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GA721_RS08650	COG2815	serine threonine protein kinase
GA721_RS08650	COG0515	serine threonine protein kinase
GA721_RS08675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GA721_RS08680	COG1610	YqeY-like protein
GA721_RS08695	COG4783	chaperone-mediated protein folding
GA721_RS08760	COG0513	Belongs to the DEAD box helicase family
GA721_RS08780	COG2363	Small membrane protein
GA721_RS08800	COG0659	secondary active sulfate transmembrane transporter activity
GA721_RS08810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GA721_RS08830	COG0318	PFAM AMP-dependent synthetase and ligase
GA721_RS08835	COG1309	transcriptional regulator
GA721_RS08840	COG1960	acyl-CoA dehydrogenase activity
GA721_RS08845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GA721_RS08850	COG1024	Enoyl-CoA hydratase
GA721_RS08870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GA721_RS08885	COG0540	Belongs to the ATCase OTCase family
GA721_RS08910	COG1765	OsmC-like protein
GA721_RS08920	COG0667	Aldo Keto reductase
GA721_RS08935	COG0501	Belongs to the peptidase M48B family
GA721_RS08940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GA721_RS08955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GA721_RS08965	COG0527	aspartate kinase activity
GA721_RS08975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GA721_RS08985	COG1215	transferase activity, transferring glycosyl groups
GA721_RS08995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GA721_RS09000	COG2252	PERMEase
GA721_RS09030	COG0714	Associated with various cellular activities
GA721_RS09035	COG2879	small protein
GA721_RS09040	COG1966	Carbon starvation protein
GA721_RS09045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GA721_RS09050	COG1509	lysine 2,3-aminomutase activity
GA721_RS09085	COG1067	ATP-dependent peptidase activity
GA721_RS09090	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GA721_RS09095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GA721_RS09100	COG0583	DNA-binding transcription factor activity
GA721_RS09110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GA721_RS09125	COG1686	Belongs to the peptidase S11 family
GA721_RS09130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GA721_RS09135	COG2801	Transposase and inactivated derivatives
GA721_RS09145	COG2801	Transposase and inactivated derivatives
GA721_RS09175	COG0616	signal peptide processing
GA721_RS09180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GA721_RS09190	COG0573	inorganic phosphate transmembrane transporter activity
GA721_RS09200	COG0076	glutamate decarboxylase activity
GA721_RS09205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GA721_RS09215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GA721_RS09225	COG2814	Major facilitator Superfamily
GA721_RS09230	COG1733	regulation of RNA biosynthetic process
GA721_RS09235	COG0702	epimerase
GA721_RS09265	COG0556	nucleotide-excision repair
GA721_RS09305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GA721_RS09310	COG1381	Involved in DNA repair and RecF pathway recombination
GA721_RS09320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GA721_RS09325	COG0571	ribonuclease III activity
GA721_RS09335	COG0681	Belongs to the peptidase S26 family
GA721_RS09350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GA721_RS09360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GA721_RS09375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GA721_RS09385	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GA721_RS09400	COG4208	sulfate ABC transporter
GA721_RS09405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GA721_RS09410	COG0583	DNA-binding transcription factor activity
GA721_RS09420	COG4625	pathogenesis
GA721_RS09430	COG0602	queuosine metabolic process
GA721_RS09435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GA721_RS09445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GA721_RS09450	COG2353	YceI-like domain
GA721_RS09455	COG1056	cytidyltransferase-related domain
GA721_RS09455	COG1051	belongs to the nudix hydrolase family
GA721_RS09460	COG1024	Enoyl-CoA hydratase
GA721_RS09465	COG0778	Nitroreductase
GA721_RS09480	COG0047	phosphoribosylformylglycinamidine synthase activity
GA721_RS09480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GA721_RS09500	COG2255	four-way junction helicase activity
GA721_RS09510	COG0824	Thioesterase
GA721_RS09530	COG0823	Involved in the tonB-independent uptake of proteins
GA721_RS09550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GA721_RS09585	COG0628	permease
GA721_RS09590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GA721_RS09595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GA721_RS09615	COG0658	competence protein
GA721_RS09615	COG2333	competence protein COMEC
GA721_RS09620	COG1136	(ABC) transporter
GA721_RS09625	COG4591	ABC-type transport system involved in lipoprotein release permease component
GA721_RS09640	COG1671	Belongs to the UPF0178 family
GA721_RS09680	COG1280	lysine exporter protein (LysE YggA)
GA721_RS09685	COG1522	sequence-specific DNA binding
GA721_RS09695	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GA721_RS09710	COG0019	diaminopimelate decarboxylase activity
GA721_RS09720	COG1113	amino acid transport
GA721_RS09725	COG1115	amino acid carrier protein
GA721_RS09745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GA721_RS09750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GA721_RS09785	COG0583	DNA-binding transcription factor activity
GA721_RS09795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GA721_RS09810	COG0512	Glutamine amidotransferase of anthranilate synthase
GA721_RS09840	COG3706	GGDEF domain
GA721_RS09855	COG3739	integral membrane protein
GA721_RS09860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GA721_RS09870	COG1741	Belongs to the pirin family
GA721_RS09875	COG3842	ATPase activity
GA721_RS09880	COG1840	ABC-type Fe3 transport system, periplasmic component
GA721_RS09900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GA721_RS09905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GA721_RS09915	COG0037	tRNA processing
GA721_RS09920	COG0739	heme binding
GA721_RS09920	COG1196	nuclear chromosome segregation
GA721_RS09920	COG0741	lytic transglycosylase activity
GA721_RS09925	COG0501	Belongs to the peptidase M48B family
GA721_RS09935	COG2239	Acts as a magnesium transporter
GA721_RS09980	COG1803	Methylglyoxal synthase
GA721_RS09980	COG1597	lipid kinase activity
GA721_RS10000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GA721_RS10035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GA721_RS10045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GA721_RS10055	COG1534	Rna-binding protein
GA721_RS10070	COG0505	Belongs to the CarA family
GA721_RS10085	COG0415	Belongs to the DNA photolyase family
GA721_RS10090	COG0110	maltose O-acetyltransferase activity
GA721_RS10095	COG0589	response to stress
GA721_RS10105	COG2321	neutral zinc metallopeptidase
GA721_RS10110	COG2354	Protein conserved in bacteria
GA721_RS10175	COG2862	Uncharacterized protein family, UPF0114
GA721_RS10225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GA721_RS10235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GA721_RS10240	COG2268	Band 7 protein
GA721_RS10250	COG1215	transferase activity, transferring glycosyl groups
GA721_RS10255	COG1649	PFAM Uncharacterised BCR, COG1649
GA721_RS10255	COG0726	polysaccharide deacetylase
GA721_RS10265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GA721_RS10275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA721_RS10290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GA721_RS10295	COG1053	succinate dehydrogenase
GA721_RS10300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GA721_RS10305	COG2009	succinate dehydrogenase
GA721_RS10315	COG2072	flavoprotein involved in K transport
GA721_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS10330	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GA721_RS10345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GA721_RS10345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GA721_RS10375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GA721_RS10385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GA721_RS10400	COG0564	pseudouridine synthase activity
GA721_RS10410	COG0358	DNA primase activity
GA721_RS10425	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GA721_RS10455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GA721_RS10495	COG0586	Pfam SNARE associated Golgi protein
GA721_RS10520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GA721_RS10530	COG0321	lipoyl(octanoyl) transferase activity
GA721_RS10545	COG0531	amino acid
GA721_RS10550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GA721_RS10555	COG1648	precorrin-2 dehydrogenase activity
GA721_RS10555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GA721_RS10560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GA721_RS10570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GA721_RS10595	COG0671	phosphoesterase, PA-phosphatase related
GA721_RS10600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA721_RS10610	COG1538	Outer membrane efflux protein
GA721_RS10620	COG0393	Putative heavy-metal-binding
GA721_RS10625	COG0393	Putative heavy-metal-binding
GA721_RS10630	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS10640	COG0525	valine-tRNA ligase activity
GA721_RS10665	COG2323	membrane
GA721_RS10675	COG0765	amino acid transport
GA721_RS10680	COG0765	amino acid transport
GA721_RS10685	COG1126	abc transporter atp-binding protein
GA721_RS10690	COG3338	carbonate dehydratase activity
GA721_RS10705	COG1752	Esterase of the alpha-beta hydrolase superfamily
GA721_RS10720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA721_RS10725	COG2205	protein histidine kinase activity
GA721_RS10730	COG0745	RESPONSE REGULATOR receiver
GA721_RS10745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GA721_RS10750	COG1652	LysM domain
GA721_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS10770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GA721_RS10775	COG1399	metal-binding, possibly nucleic acid-binding protein
GA721_RS10780	COG3101	peptidyl-lysine hydroxylation
GA721_RS10785	COG0009	L-threonylcarbamoyladenylate synthase
GA721_RS10795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GA721_RS10800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GA721_RS10815	COG4106	trans-aconitate 2-methyltransferase activity
GA721_RS10830	COG2226	methyltransferase
GA721_RS10830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA721_RS10830	COG0596	Alpha beta hydrolase
GA721_RS10835	COG2193	ferroxidase activity
GA721_RS10840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GA721_RS10845	COG3115	cell septum assembly
GA721_RS10850	COG1196	nuclear chromosome segregation
GA721_RS10860	COG0730	response to heat
GA721_RS10880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GA721_RS10895	COG2801	Transposase and inactivated derivatives
GA721_RS10920	COG2824	Alkylphosphonate utilization operon protein PhnA
GA721_RS10925	COG3189	MarR family transcriptional regulator
GA721_RS10940	COG0564	pseudouridine synthase activity
GA721_RS10980	COG0354	folic acid binding
GA721_RS11010	COG0363	glucosamine-6-phosphate deaminase activity
GA721_RS11020	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GA721_RS11025	COG1877	trehalose-phosphatase activity
GA721_RS11035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GA721_RS11040	COG1970	mechanosensitive ion channel activity
GA721_RS11050	COG2233	PERMEase
GA721_RS11060	COG0833	amino acid
GA721_RS11070	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GA721_RS11070	COG2885	chlorophyll binding
GA721_RS11080	COG0183	Belongs to the thiolase family
GA721_RS11100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA721_RS11110	COG2207	Transcriptional regulator
GA721_RS11115	COG0183	Belongs to the thiolase family
GA721_RS11120	COG1250	3-hydroxyacyl-CoA dehydrogenase
GA721_RS11120	COG1024	Enoyl-CoA hydratase
GA721_RS11135	COG2153	protein acetylation
GA721_RS11145	COG1272	protein, Hemolysin III
GA721_RS11150	COG0477	Major facilitator Superfamily
GA721_RS11160	COG1408	metallophosphoesterase
GA721_RS11165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GA721_RS11175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GA721_RS11205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GA721_RS11210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GA721_RS11215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GA721_RS11225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GA721_RS11230	COG0625	glutathione transferase activity
GA721_RS11235	COG2969	positive regulation of protein catabolic process
GA721_RS11290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GA721_RS11335	COG0037	tRNA processing
GA721_RS11370	COG0072	phenylalanine-tRNA ligase activity
GA721_RS11390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GA721_RS11405	COG1238	metal cluster binding
GA721_RS11410	COG0625	glutathione transferase activity
GA721_RS11425	COG0318	PFAM AMP-dependent synthetase and ligase
GA721_RS11430	COG3028	Belongs to the UPF0307 family
GA721_RS11440	COG1660	Displays ATPase and GTPase activities
GA721_RS11455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GA721_RS11460	COG0617	tRNA 3'-terminal CCA addition
GA721_RS11465	COG1555	photosystem II stabilization
GA721_RS11470	COG3956	TIGRFAM MazG family protein
GA721_RS11485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GA721_RS11495	COG0124	histidyl-tRNA synthetase
GA721_RS11525	COG2975	iron-sulfur cluster assembly
GA721_RS11565	COG0440	acetolactate synthase activity
GA721_RS11570	COG0028	Belongs to the TPP enzyme family
GA721_RS11595	COG2703	oxygen carrier activity
GA721_RS11600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA721_RS11605	COG0577	efflux transmembrane transporter activity
GA721_RS11605	COG1136	(ABC) transporter
GA721_RS11630	COG3501	Rhs element vgr protein
GA721_RS11645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GA721_RS11650	COG1162	GTPase activity
GA721_RS11660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GA721_RS11670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GA721_RS11680	COG3781	membrane
GA721_RS11685	COG0613	PHP domain protein
GA721_RS11695	COG2350	Protein conserved in bacteria
GA721_RS11715	COG1666	GTP binding
GA721_RS11725	COG1607	acyl-coa hydrolase
GA721_RS11740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GA721_RS11740	COG3453	Protein conserved in bacteria
GA721_RS11790	COG1183	phosphatidylcholine synthase activity
GA721_RS11795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GA721_RS11835	COG0741	lytic transglycosylase activity
GA721_RS11835	COG0739	heme binding
GA721_RS11835	COG1196	nuclear chromosome segregation
GA721_RS11840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GA721_RS11845	COG1702	phosphate starvation-inducible protein PhoH
GA721_RS11895	COG1295	ribonuclease BN
GA721_RS11925	COG0788	formyltetrahydrofolate deformylase activity
GA721_RS11940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GA721_RS11945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GA721_RS11950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GA721_RS11950	COG4651	solute:proton antiporter activity
GA721_RS11965	COG0724	RNA recognition motif
GA721_RS11970	COG0210	DNA helicase
GA721_RS11980	COG1929	Belongs to the glycerate kinase type-1 family
GA721_RS12020	COG1560	Kdo2-lipid A biosynthetic process
GA721_RS12075	COG0473	3-isopropylmalate dehydrogenase activity
GA721_RS12090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GA721_RS12120	COG0494	nUDIX hydrolase
GA721_RS12140	COG1960	acyl-CoA dehydrogenase activity
GA721_RS12150	COG0753	catalase activity
GA721_RS12165	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA721_RS12170	COG3384	dioxygenase
GA721_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
GA721_RS12190	COG4638	Rieske (2fe-2S)
GA721_RS12195	COG0583	DNA-binding transcription factor activity
GA721_RS12220	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GA721_RS12225	COG3971	2-oxopent-4-enoate hydratase activity
GA721_RS12230	COG0546	phosphoglycolate phosphatase activity
GA721_RS12240	COG1530	ribonuclease E activity
GA721_RS12270	COG1983	PspC domain protein
GA721_RS12285	COG0751	glycine-tRNA ligase activity
GA721_RS12310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GA721_RS12335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GA721_RS12335	COG0493	'glutamate synthase
GA721_RS12345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GA721_RS12355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GA721_RS12370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GA721_RS12380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GA721_RS12380	COG0644	oxidoreductase
GA721_RS12395	COG2801	Transposase and inactivated derivatives
GA721_RS12435	COG3501	Rhs element vgr protein
GA721_RS12440	COG0425	Belongs to the sulfur carrier protein TusA family
GA721_RS12445	COG4535	Mg2 and Co2 transporter CorC
GA721_RS12450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GA721_RS12470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GA721_RS12480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GA721_RS12490	COG0789	Transcriptional regulator
GA721_RS12495	COG2841	Protein conserved in bacteria
GA721_RS12510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GA721_RS12520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GA721_RS12525	COG1074	ATP-dependent DNA helicase activity
GA721_RS12530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GA721_RS12560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GA721_RS12570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GA721_RS12585	COG2111	Na H antiporter
GA721_RS12585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GA721_RS12590	COG1006	Multisubunit Na H antiporter MnhC subunit
GA721_RS12595	COG0651	ATP synthesis coupled electron transport
GA721_RS12605	COG2212	antiporter activity
GA721_RS12615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GA721_RS12625	COG0195	Participates in both transcription termination and antitermination
GA721_RS12630	COG0779	Required for maturation of 30S ribosomal subunits
GA721_RS12680	COG0237	dephospho-CoA kinase activity
GA721_RS12690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GA721_RS12695	COG3123	guanosine phosphorylase activity
GA721_RS12700	COG0497	DNA recombination
GA721_RS12710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GA721_RS12725	COG1132	(ABC) transporter
GA721_RS12730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GA721_RS12740	COG0322	excinuclease ABC activity
GA721_RS12760	COG1024	Enoyl-CoA hydratase
GA721_RS12760	COG1250	3-hydroxyacyl-CoA dehydrogenase
GA721_RS12770	COG3385	transposase activity
GA721_RS12775	COG2233	PERMEase
GA721_RS12785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GA721_RS12815	COG0326	Molecular chaperone. Has ATPase activity
GA721_RS12835	COG2056	Na+-H+ antiporter family
GA721_RS12855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GA721_RS12860	COG0085	RNA polymerase activity
GA721_RS12875	COG0081	regulation of translation
GA721_RS12960	COG0824	Thioesterase
GA721_RS12980	COG0181	hydroxymethylbilane synthase activity
GA721_RS12990	COG3275	phosphorelay sensor kinase activity
GA721_RS13025	COG0494	nUDIX hydrolase
GA721_RS13030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GA721_RS13035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GA721_RS13040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GA721_RS13050	COG0772	Belongs to the SEDS family
GA721_RS13075	COG4974	Belongs to the 'phage' integrase family
GA721_RS13090	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GA721_RS13100	COG2197	response regulator
GA721_RS13115	COG0793	Belongs to the peptidase S41A family
GA721_RS13120	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GA721_RS13125	COG0795	lipopolysaccharide-transporting ATPase activity
GA721_RS13130	COG0795	lipopolysaccharide-transporting ATPase activity
GA721_RS13155	COG0586	Pfam SNARE associated Golgi protein
GA721_RS13170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GA721_RS13170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GA721_RS13180	COG0004	ammonium transporteR
GA721_RS13185	COG0347	Belongs to the P(II) protein family
GA721_RS13210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GA721_RS13225	COG0318	PFAM AMP-dependent synthetase and ligase
GA721_RS13235	COG0477	Major facilitator Superfamily
GA721_RS13240	COG2860	membrane
GA721_RS13250	COG1253	flavin adenine dinucleotide binding
GA721_RS13270	COG2814	Major facilitator Superfamily
GA721_RS13285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GA721_RS13305	COG2814	Major facilitator Superfamily
GA721_RS13355	COG0758	DNA mediated transformation
GA721_RS13370	COG0697	spore germination
GA721_RS13375	COG0386	Belongs to the glutathione peroxidase family
GA721_RS13405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GA721_RS13415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GA721_RS13455	COG1121	(ABC) transporter
GA721_RS13460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GA721_RS13470	COG2837	iron assimilation
GA721_RS13490	COG3501	Rhs element vgr protein
GA721_RS13495	COG0281	malic enzyme
GA721_RS13530	COG0745	RESPONSE REGULATOR receiver
GA721_RS13530	COG3706	GGDEF domain
GA721_RS13535	COG0519	Catalyzes the synthesis of GMP from XMP
GA721_RS13535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GA721_RS13540	COG2259	Doxx family
GA721_RS13545	COG0586	Pfam SNARE associated Golgi protein
GA721_RS13560	COG1192	Involved in chromosome partitioning
GA721_RS13570	COG0271	Belongs to the BolA IbaG family
GA721_RS13590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GA721_RS13605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GA721_RS13615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GA721_RS13650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GA721_RS13665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GA721_RS13675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GA721_RS13685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GA721_RS13705	COG0438	transferase activity, transferring glycosyl groups
GA721_RS13710	COG0463	Glycosyl transferase, family 2
GA721_RS13715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GA721_RS13780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA721_RS13785	COG1309	transcriptional regulator
GA721_RS13795	COG2233	PERMEase
GA721_RS13810	COG0129	dihydroxy-acid dehydratase activity
GA721_RS13830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GA721_RS13840	COG0733	neurotransmitter:sodium symporter activity
GA721_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
GA721_RS13855	COG2814	Major facilitator Superfamily
GA721_RS13885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GA721_RS13930	COG2951	lytic endotransglycosylase activity
GA721_RS13935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GA721_RS13955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GA721_RS13965	COG2388	GCN5-related N-acetyl-transferase
GA721_RS13975	COG0861	Integral membrane protein TerC family
GA721_RS13980	COG0402	S-adenosylhomocysteine deaminase activity
GA721_RS13995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GA721_RS14000	COG1230	cation diffusion facilitator family transporter
GA721_RS14025	COG0706	membrane insertase activity
GA721_RS14030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GA721_RS14035	COG0594	ribonuclease P activity
GA721_RS14040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GA721_RS14065	COG4974	Belongs to the 'phage' integrase family
GA721_RS14095	COG4974	Belongs to the 'phage' integrase family
GA721_RS14125	COG4974	Belongs to the 'phage' integrase family
GA721_RS14155	COG4974	Belongs to the 'phage' integrase family
GA721_RS14200	COG2963	transposase activity
GA721_RS14210	COG1192	Involved in chromosome partitioning
GA721_RS14230	COG4680	protein conserved in bacteria
GA721_RS14260	COG0789	Transcriptional regulator
GA721_RS14325	COG0582	viral genome integration into host DNA
GA721_RS14330	COG2369	cell adhesion
GA721_RS14340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GA721_RS14350	COG3316	Transposase and inactivated derivatives
GA721_RS14360	COG3173	Aminoglycoside phosphotransferase
GA721_RS14365	COG2801	Transposase and inactivated derivatives
GA721_RS14380	COG3316	Transposase and inactivated derivatives
GA721_RS14395	COG3316	Transposase and inactivated derivatives
GA721_RS14445	COG4372	Transposase
GA721_RS14460	COG3316	Transposase and inactivated derivatives
GA721_RS14465	COG1660	Displays ATPase and GTPase activities
GA721_RS14495	COG0659	secondary active sulfate transmembrane transporter activity
GA721_RS14500	COG0589	response to stress
GA721_RS14505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GA721_RS14555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GA721_RS14585	COG2826	transposase and inactivated derivatives, IS30 family
GA721_RS14605	COG0673	inositol 2-dehydrogenase activity
GA721_RS14625	COG1525	nuclease
GA721_RS14650	COG0741	lytic transglycosylase activity
GA721_RS14650	COG1196	nuclear chromosome segregation
GA721_RS14650	COG0739	heme binding
GA721_RS14665	COG0741	lytic transglycosylase activity
GA721_RS14665	COG1196	nuclear chromosome segregation
GA721_RS14665	COG0739	heme binding
GA721_RS14720	COG1192	Involved in chromosome partitioning