locus-tag	class	description
GA646_RS00080	COG3316	Transposase and inactivated derivatives
GA646_RS00095	COG1230	cation diffusion facilitator family transporter
GA646_RS00110	COG0582	viral genome integration into host DNA
GA646_RS00130	COG0069	glutamate synthase activity
GA646_RS00135	COG2218	PFAM glutamate synthase alpha subunit domain protein
GA646_RS00140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GA646_RS00150	COG1396	sequence-specific DNA binding
GA646_RS00155	COG0004	ammonium transporteR
GA646_RS00160	COG0004	ammonium transporteR
GA646_RS00180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GA646_RS00185	COG2132	Multicopper oxidase
GA646_RS00200	COG2801	Transposase and inactivated derivatives
GA646_RS00205	COG3077	Addiction module antitoxin, RelB DinJ family
GA646_RS00215	COG2801	Transposase and inactivated derivatives
GA646_RS00230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GA646_RS00235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GA646_RS00250	COG2132	Multicopper oxidase
GA646_RS00265	COG2205	protein histidine kinase activity
GA646_RS00270	COG3174	membrane
GA646_RS00275	COG2217	Heavy metal translocating P-type atpase
GA646_RS00325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GA646_RS00330	COG3316	Transposase and inactivated derivatives
GA646_RS00360	COG2801	Transposase and inactivated derivatives
GA646_RS00365	COG0659	secondary active sulfate transmembrane transporter activity
GA646_RS00370	COG0589	response to stress
GA646_RS00375	COG2072	flavoprotein involved in K transport
GA646_RS00380	COG0492	ferredoxin-NADP+ reductase activity
GA646_RS00385	COG0431	NADPH-dependent FMN reductase
GA646_RS00390	COG0798	PFAM Bile acid sodium symporter
GA646_RS00400	COG0640	Transcriptional regulator
GA646_RS00410	COG0745	RESPONSE REGULATOR receiver
GA646_RS00445	COG3316	Transposase and inactivated derivatives
GA646_RS00470	COG3316	Transposase and inactivated derivatives
GA646_RS00560	COG1373	ATPase (AAA superfamily
GA646_RS00580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GA646_RS00600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GA646_RS00600	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA646_RS00615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GA646_RS00640	COG0347	Belongs to the P(II) protein family
GA646_RS00655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GA646_RS00675	COG2197	response regulator
GA646_RS00680	COG3850	Histidine kinase
GA646_RS00685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GA646_RS00690	COG1475	DNA binding
GA646_RS00695	COG1192	Involved in chromosome partitioning
GA646_RS00715	COG3604	Transcriptional regulator
GA646_RS00740	COG2144	transferase activity, transferring acyl groups
GA646_RS00750	COG2072	flavoprotein involved in K transport
GA646_RS00765	COG0515	serine threonine protein kinase
GA646_RS00765	COG2815	serine threonine protein kinase
GA646_RS00775	COG2801	Transposase and inactivated derivatives
GA646_RS00825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GA646_RS00845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GA646_RS00850	COG0592	DNA-directed DNA polymerase activity
GA646_RS00860	COG0187	DNA topoisomerase II activity
GA646_RS00885	COG0488	(ABC) transporter
GA646_RS00910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GA646_RS00915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GA646_RS00965	COG2814	Major facilitator Superfamily
GA646_RS00970	COG2133	pyrroloquinoline quinone binding
GA646_RS00980	COG1047	Peptidyl-prolyl cis-trans
GA646_RS00985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GA646_RS00990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GA646_RS00995	COG0196	riboflavin kinase activity
GA646_RS01005	COG1309	transcriptional regulator
GA646_RS01020	COG1116	anion transmembrane transporter activity
GA646_RS01025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GA646_RS01030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA646_RS01035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GA646_RS01040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GA646_RS01045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GA646_RS01045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GA646_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS01070	COG0546	phosphoglycolate phosphatase activity
GA646_RS01075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GA646_RS01085	COG1309	transcriptional regulator
GA646_RS01090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GA646_RS01100	COG3023	N-Acetylmuramoyl-L-alanine amidase
GA646_RS01120	COG1064	alcohol dehydrogenase
GA646_RS01125	COG2818	Glycosylase
GA646_RS01135	COG0739	heme binding
GA646_RS01140	COG1194	a g-specific adenine glycosylase
GA646_RS01155	COG5487	UPF0391 membrane protein
GA646_RS01160	COG2983	Belongs to the UPF0260 family
GA646_RS01165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GA646_RS01170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GA646_RS01180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GA646_RS01185	COG2814	Major facilitator Superfamily
GA646_RS01190	COG1335	isochorismatase
GA646_RS01195	COG0385	Bile acid
GA646_RS01210	COG0560	Phosphoserine phosphatase
GA646_RS01210	COG3830	Belongs to the UPF0237 family
GA646_RS01230	COG0753	catalase activity
GA646_RS01275	COG2175	clavaminate synthase activity
GA646_RS01280	COG0534	Mate efflux family protein
GA646_RS01285	COG0436	Aminotransferase
GA646_RS01290	COG2733	membrane
GA646_RS01305	COG2918	glutathione biosynthetic process
GA646_RS01310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GA646_RS01320	COG3150	esterase
GA646_RS01335	COG0559	Belongs to the binding-protein-dependent transport system permease family
GA646_RS01350	COG0410	ABC transporter
GA646_RS01355	COG0471	metal ion transport
GA646_RS01370	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GA646_RS01375	COG4266	Belongs to the allantoicase family
GA646_RS01380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GA646_RS01385	COG1247	-acetyltransferase
GA646_RS01395	COG2351	hydroxyisourate hydrolase activity
GA646_RS01415	COG3385	transposase activity
GA646_RS01435	COG0625	glutathione transferase activity
GA646_RS01440	COG3706	GGDEF domain
GA646_RS01445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GA646_RS01460	COG1393	Belongs to the ArsC family
GA646_RS01465	COG0708	Exodeoxyribonuclease III
GA646_RS01485	COG0189	ligase activity
GA646_RS01490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GA646_RS01495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GA646_RS01505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GA646_RS01515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GA646_RS01545	COG2119	membrane
GA646_RS01550	COG0426	domain, Protein
GA646_RS01550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GA646_RS01560	COG3385	transposase activity
GA646_RS01580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GA646_RS01590	COG3385	transposase activity
GA646_RS01610	COG1902	pentaerythritol trinitrate reductase activity
GA646_RS01615	COG1519	Transferase
GA646_RS01620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GA646_RS01625	COG0668	transmembrane transport
GA646_RS01630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GA646_RS01640	COG0431	NADPH-dependent FMN reductase
GA646_RS01655	COG2205	protein histidine kinase activity
GA646_RS01655	COG0784	Response regulator, receiver
GA646_RS01660	COG3162	membrane
GA646_RS01665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA646_RS01685	COG2801	Transposase and inactivated derivatives
GA646_RS01690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GA646_RS01700	COG3706	GGDEF domain
GA646_RS01705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GA646_RS01710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GA646_RS01720	COG2814	Major facilitator Superfamily
GA646_RS01725	COG0629	single-stranded DNA binding
GA646_RS01730	COG0450	alkyl hydroperoxide reductase
GA646_RS01740	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GA646_RS01760	COG1943	Transposase
GA646_RS01810	COG3328	transposase activity
GA646_RS01830	COG3328	transposase activity
GA646_RS01875	COG0582	viral genome integration into host DNA
GA646_RS01885	COG3158	transport of potassium into the cell
GA646_RS01925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GA646_RS01940	COG0697	spore germination
GA646_RS01960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GA646_RS01990	COG0427	acetyl-CoA hydrolase
GA646_RS01995	COG2205	protein histidine kinase activity
GA646_RS02000	COG0745	RESPONSE REGULATOR receiver
GA646_RS02015	COG3328	transposase activity
GA646_RS02025	COG4221	oxidoreductase activity
GA646_RS02035	COG0488	(ABC) transporter
GA646_RS02055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GA646_RS02065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GA646_RS02075	COG0275	rRNA processing
GA646_RS02090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GA646_RS02095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GA646_RS02105	COG2226	methyltransferase
GA646_RS02130	COG1943	Transposase
GA646_RS02170	COG0067	glutamate synthase
GA646_RS02170	COG0069	glutamate synthase activity
GA646_RS02170	COG0070	glutamate synthase
GA646_RS02175	COG0493	'glutamate synthase
GA646_RS02185	COG1704	LemA family
GA646_RS02190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GA646_RS02205	COG3307	-O-antigen
GA646_RS02215	COG2906	2 iron, 2 sulfur cluster binding
GA646_RS02225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GA646_RS02230	COG1758	RNA polymerase activity
GA646_RS02235	COG0194	GDP metabolic process
GA646_RS02265	COG3328	transposase activity
GA646_RS02275	COG0335	large ribosomal subunit rRNA binding
GA646_RS02285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GA646_RS02290	COG0228	four-way junction DNA binding
GA646_RS02295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GA646_RS02315	COG5006	permease, DMT superfamily
GA646_RS02320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GA646_RS02325	COG0277	FAD linked oxidase domain protein
GA646_RS02340	COG2814	Major facilitator Superfamily
GA646_RS02350	COG0628	permease
GA646_RS02355	COG1192	Involved in chromosome partitioning
GA646_RS02375	COG1943	Transposase
GA646_RS02380	COG2226	methyltransferase
GA646_RS02405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GA646_RS02410	COG0254	rRNA binding
GA646_RS02415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GA646_RS02420	COG0534	Mate efflux family protein
GA646_RS02430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GA646_RS02435	COG1960	acyl-CoA dehydrogenase activity
GA646_RS02450	COG0408	coproporphyrinogen oxidase activity
GA646_RS02455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GA646_RS02485	COG1127	ABC transporter
GA646_RS02490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GA646_RS02495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GA646_RS02500	COG2854	intermembrane phospholipid transfer
GA646_RS02510	COG0598	Magnesium transport protein CorA
GA646_RS02525	COG1040	competence protein
GA646_RS02530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GA646_RS02540	COG2937	Belongs to the GPAT DAPAT family
GA646_RS02545	COG1946	Acyl-CoA thioesterase
GA646_RS02550	COG1301	dicarboxylic acid transport
GA646_RS02585	COG1959	2 iron, 2 sulfur cluster binding
GA646_RS02590	COG1017	nitric oxide dioxygenase activity
GA646_RS02590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GA646_RS02595	COG0433	COG0433 Predicted ATPase
GA646_RS02620	COG0088	Forms part of the polypeptide exit tunnel
GA646_RS02650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GA646_RS02675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GA646_RS02685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GA646_RS02690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GA646_RS02700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GA646_RS02720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GA646_RS02730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GA646_RS02735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GA646_RS02740	COG0202	RNA polymerase activity
GA646_RS02750	COG2072	flavoprotein involved in K transport
GA646_RS02755	COG1960	acyl-CoA dehydrogenase activity
GA646_RS02760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GA646_RS02780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GA646_RS02795	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GA646_RS02800	COG0339	signal peptide processing
GA646_RS02805	COG0557	exoribonuclease II activity
GA646_RS02840	COG0179	Fumarylacetoacetate (FAA) hydrolase
GA646_RS02870	COG3040	lipid binding
GA646_RS02930	COG2813	Specifically methylates the guanine in position
GA646_RS02930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA646_RS02935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA646_RS02940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GA646_RS02950	COG3128	pkhd-type hydroxylase
GA646_RS02955	COG4774	siderophore transport
GA646_RS02960	COG4771	TonB-dependent receptor
GA646_RS02970	COG0740	serine-type endopeptidase activity
GA646_RS02985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GA646_RS02985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GA646_RS02995	COG0280	phosphate acetyltransferase
GA646_RS02995	COG0857	belongs to the CobB CobQ family
GA646_RS03000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GA646_RS03030	COG0793	Belongs to the peptidase S41A family
GA646_RS03045	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GA646_RS03060	COG0084	hydrolase, TatD family'
GA646_RS03065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GA646_RS03070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GA646_RS03100	COG2814	Major facilitator Superfamily
GA646_RS03105	COG0697	spore germination
GA646_RS03110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GA646_RS03115	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GA646_RS03120	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GA646_RS03130	COG3622	Belongs to the hyi family
GA646_RS03140	COG1024	Enoyl-CoA hydratase
GA646_RS03145	COG5002	protein histidine kinase activity
GA646_RS03145	COG0784	Response regulator, receiver
GA646_RS03145	COG2205	protein histidine kinase activity
GA646_RS03165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GA646_RS03185	COG1862	Preprotein translocase
GA646_RS03200	COG1704	LemA family
GA646_RS03210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GA646_RS03225	COG5002	protein histidine kinase activity
GA646_RS03230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GA646_RS03260	COG4641	Protein conserved in bacteria
GA646_RS03260	COG0438	transferase activity, transferring glycosyl groups
GA646_RS03270	COG1091	dTDP-4-dehydrorhamnose reductase activity
GA646_RS03285	COG1215	transferase activity, transferring glycosyl groups
GA646_RS03315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GA646_RS03340	COG0675	Transposase, IS605 OrfB family
GA646_RS03350	COG3223	Belongs to the PsiE family
GA646_RS03355	COG1960	acyl-CoA dehydrogenase activity
GA646_RS03360	COG1960	acyl-CoA dehydrogenase activity
GA646_RS03370	COG2205	protein histidine kinase activity
GA646_RS03375	COG0745	RESPONSE REGULATOR receiver
GA646_RS03385	COG2315	Protein conserved in bacteria
GA646_RS03390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GA646_RS03395	COG3385	transposase activity
GA646_RS03415	COG2096	Adenosyltransferase
GA646_RS03420	COG4206	TonB-dependent receptor
GA646_RS03430	COG0133	tryptophan synthase activity
GA646_RS03465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GA646_RS03470	COG0285	dihydrofolate synthase activity
GA646_RS03485	COG0450	alkyl hydroperoxide reductase
GA646_RS03500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GA646_RS03505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GA646_RS03535	COG2199	diguanylate cyclase activity
GA646_RS03595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GA646_RS03600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GA646_RS03625	COG1943	Transposase
GA646_RS03640	COG0494	nUDIX hydrolase
GA646_RS03650	COG1214	PFAM Peptidase M22, glycoprotease
GA646_RS03655	COG1968	undecaprenyl-diphosphatase activity
GA646_RS03675	COG4269	membrane
GA646_RS03685	COG1943	Transposase
GA646_RS03700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GA646_RS03710	COG2132	Multicopper oxidase
GA646_RS03720	COG2076	Multidrug Resistance protein
GA646_RS03725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GA646_RS03740	COG0351	phosphomethylpyrimidine kinase
GA646_RS03740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GA646_RS03740	COG0352	thiamine-phosphate diphosphorylase activity
GA646_RS03750	COG1522	sequence-specific DNA binding
GA646_RS03765	COG0251	oxidation-reduction process
GA646_RS03770	COG1113	amino acid transport
GA646_RS03790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GA646_RS03815	COG0456	acetyltransferase
GA646_RS03825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GA646_RS03830	COG0492	ferredoxin-NADP+ reductase activity
GA646_RS03835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GA646_RS03835	COG1674	ftsk spoiiie
GA646_RS03850	COG2894	cell division
GA646_RS03855	COG0850	regulation of cytokinetic process
GA646_RS03865	COG0204	Acyl-transferase
GA646_RS03870	COG2885	chlorophyll binding
GA646_RS03875	COG0210	DNA helicase
GA646_RS03880	COG0756	dUTP diphosphatase activity
GA646_RS03885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GA646_RS03920	COG0121	glutamine amidotransferase
GA646_RS03935	COG2914	Belongs to the UPF0125 (RnfH) family
GA646_RS03940	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GA646_RS03945	COG0735	belongs to the Fur family
GA646_RS03975	COG0420	3'-5' exonuclease activity
GA646_RS03995	COG2050	protein possibly involved in aromatic compounds catabolism
GA646_RS04000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GA646_RS04010	COG0582	viral genome integration into host DNA
GA646_RS04045	COG2184	nucleotidyltransferase activity
GA646_RS04055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GA646_RS04065	COG4804	nuclease activity
GA646_RS04110	COG1414	Transcriptional regulator
GA646_RS04115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GA646_RS04120	COG1414	Transcriptional regulator
GA646_RS04125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GA646_RS04130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GA646_RS04135	COG0183	Belongs to the thiolase family
GA646_RS04140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GA646_RS04145	COG0596	Alpha beta hydrolase
GA646_RS04150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GA646_RS04155	COG3485	protocatechuate 3,4-dioxygenase
GA646_RS04160	COG3485	protocatechuate 3,4-dioxygenase
GA646_RS04190	COG1960	acyl-CoA dehydrogenase activity
GA646_RS04200	COG1012	belongs to the aldehyde dehydrogenase family
GA646_RS04205	COG1024	Enoyl-CoA hydratase
GA646_RS04210	COG2814	Major facilitator Superfamily
GA646_RS04225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GA646_RS04240	COG3177	Filamentation induced by cAMP protein fic
GA646_RS04260	COG0726	polysaccharide deacetylase
GA646_RS04260	COG1649	PFAM Uncharacterised BCR, COG1649
GA646_RS04265	COG1215	transferase activity, transferring glycosyl groups
GA646_RS04280	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GA646_RS04310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GA646_RS04315	COG0154	amidase activity
GA646_RS04320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GA646_RS04325	COG1077	Cell shape determining protein MreB Mrl
GA646_RS04330	COG1792	Involved in formation and maintenance of cell shape
GA646_RS04335	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GA646_RS04340	COG0424	maF-like protein
GA646_RS04345	COG1530	ribonuclease E activity
GA646_RS04355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GA646_RS04395	COG0625	glutathione transferase activity
GA646_RS04420	COG1113	amino acid transport
GA646_RS04425	COG2828	Protein conserved in bacteria
GA646_RS04430	COG0142	geranyltranstransferase activity
GA646_RS04440	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GA646_RS04460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GA646_RS04470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GA646_RS04475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GA646_RS04480	COG0839	Belongs to the complex I subunit 6 family
GA646_RS04485	COG0713	ATP synthesis coupled electron transport
GA646_RS04490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GA646_RS04495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GA646_RS04510	COG1278	Cold shock
GA646_RS04515	COG1278	Cold shock
GA646_RS04520	COG0583	DNA-binding transcription factor activity
GA646_RS04545	COG0668	transmembrane transport
GA646_RS04555	COG2081	HI0933 family
GA646_RS04570	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GA646_RS04590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA646_RS04590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA646_RS04595	COG0489	protein tyrosine kinase activity
GA646_RS04645	COG0442	prolyl-tRNA aminoacylation
GA646_RS04690	COG0643	Histidine kinase
GA646_RS04690	COG2198	Histidine kinase
GA646_RS04705	COG5510	response to toxic substance
GA646_RS04715	COG2832	Protein of unknown function (DUF454)
GA646_RS04720	COG1376	ErfK ybiS ycfS ynhG family protein
GA646_RS04775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GA646_RS04785	COG1289	transmembrane transporter activity
GA646_RS04790	COG2814	Major facilitator Superfamily
GA646_RS04805	COG0786	glutamate:sodium symporter activity
GA646_RS04810	COG1115	amino acid carrier protein
GA646_RS04815	COG2059	Chromate
GA646_RS04820	COG1752	Esterase of the alpha-beta hydrolase superfamily
GA646_RS04830	COG1607	acyl-coa hydrolase
GA646_RS04835	COG1309	transcriptional regulator
GA646_RS04840	COG2814	Major facilitator Superfamily
GA646_RS04845	COG0583	DNA-binding transcription factor activity
GA646_RS04850	COG0625	glutathione transferase activity
GA646_RS04865	COG0523	cobalamin synthesis protein
GA646_RS04870	COG4681	YaeQ
GA646_RS04885	COG1943	Transposase
GA646_RS04935	COG2066	Belongs to the glutaminase family
GA646_RS04940	COG2376	Dihydroxyacetone kinase
GA646_RS04950	COG2963	transposase activity
GA646_RS04960	COG4372	Transposase
GA646_RS04975	COG0306	phosphate transporter
GA646_RS05000	COG4771	TonB-dependent receptor
GA646_RS05005	COG0500	methyltransferase
GA646_RS05030	COG4181	ATPase activity
GA646_RS05035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GA646_RS05045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GA646_RS05055	COG0583	DNA-binding transcription factor activity
GA646_RS05065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA646_RS05070	COG1773	rubredoxin
GA646_RS05075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GA646_RS05095	COG0175	sulfate reduction
GA646_RS05105	COG3385	transposase activity
GA646_RS05135	COG1253	flavin adenine dinucleotide binding
GA646_RS05155	COG3015	lipoprotein NlpE involved in copper resistance
GA646_RS05160	COG0204	Acyl-transferase
GA646_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS05190	COG0804	urea catabolic process
GA646_RS05205	COG0830	nickel cation binding
GA646_RS05220	COG0742	ribosomal rna small subunit methyltransferase
GA646_RS05225	COG0768	penicillin binding
GA646_RS05250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GA646_RS05255	COG2878	Part of a membrane complex involved in electron transport
GA646_RS05260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GA646_RS05270	COG3384	dioxygenase
GA646_RS05280	COG2234	aminopeptidase activity
GA646_RS05290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GA646_RS05325	COG2186	Transcriptional regulator
GA646_RS05335	COG0277	FAD linked oxidase domain protein
GA646_RS05365	COG3079	Belongs to the UPF0149 family
GA646_RS05370	COG0006	proline dipeptidase activity
GA646_RS05375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GA646_RS05380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GA646_RS05415	COG2816	NAD+ diphosphatase activity
GA646_RS05425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GA646_RS05430	COG0741	lytic transglycosylase activity
GA646_RS05430	COG1388	LysM domain
GA646_RS05435	COG4166	transmembrane transport
GA646_RS05440	COG4174	ABC transporter (Permease)
GA646_RS05445	COG4239	(ABC) transporter, permease
GA646_RS05450	COG4172	Belongs to the ABC transporter superfamily
GA646_RS05480	COG0833	amino acid
GA646_RS05500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GA646_RS05505	COG0418	dihydroorotase activity
GA646_RS05510	COG5001	Diguanylate cyclase
GA646_RS05510	COG4251	negative regulation of phosphorylation
GA646_RS05510	COG3706	GGDEF domain
GA646_RS05510	COG2203	Gaf domain
GA646_RS05525	COG1902	pentaerythritol trinitrate reductase activity
GA646_RS05525	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA646_RS05545	COG4372	Transposase
GA646_RS05600	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GA646_RS05620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GA646_RS05625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GA646_RS05630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GA646_RS05660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GA646_RS05670	COG2175	clavaminate synthase activity
GA646_RS05685	COG0024	Methionine aminopeptidase
GA646_RS05690	COG0052	Belongs to the universal ribosomal protein uS2 family
GA646_RS05715	COG2951	lytic endotransglycosylase activity
GA646_RS05730	COG0842	Transport permease protein
GA646_RS05735	COG1131	(ABC) transporter
GA646_RS05790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GA646_RS05810	COG3634	alkyl hydroperoxide reductase activity
GA646_RS05815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GA646_RS05830	COG0640	Transcriptional regulator
GA646_RS05840	COG0798	PFAM Bile acid sodium symporter
GA646_RS05845	COG0431	NADPH-dependent FMN reductase
GA646_RS05850	COG0789	Transcriptional regulator
GA646_RS05865	COG1720	tRNA m6t6A37 methyltransferase activity
GA646_RS05875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GA646_RS05885	COG0745	RESPONSE REGULATOR receiver
GA646_RS05890	COG0642	Histidine kinase
GA646_RS05910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GA646_RS05915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GA646_RS05920	COG3139	Protein of unknown function (DUF1315)
GA646_RS05935	COG1301	dicarboxylic acid transport
GA646_RS05940	COG1960	acyl-CoA dehydrogenase activity
GA646_RS05945	COG0693	protein deglycase activity
GA646_RS05955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GA646_RS05960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GA646_RS05985	COG1047	Peptidyl-prolyl cis-trans
GA646_RS05990	COG1252	NADH dehydrogenase
GA646_RS05995	COG1686	Belongs to the peptidase S11 family
GA646_RS06010	COG1187	pseudouridine synthase activity
GA646_RS06020	COG0739	heme binding
GA646_RS06030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GA646_RS06040	COG0612	Peptidase, M16
GA646_RS06075	COG0352	thiamine-phosphate diphosphorylase activity
GA646_RS06120	COG0596	Alpha beta hydrolase
GA646_RS06125	COG1309	transcriptional regulator
GA646_RS06165	COG1278	Cold shock
GA646_RS06180	COG2070	2-Nitropropane dioxygenase
GA646_RS06205	COG2391	methyltransferase activity
GA646_RS06215	COG3634	alkyl hydroperoxide reductase activity
GA646_RS06240	COG0450	alkyl hydroperoxide reductase
GA646_RS06245	COG1643	Atp-dependent helicase
GA646_RS06270	COG0517	IMP dehydrogenase activity
GA646_RS06270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GA646_RS06275	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GA646_RS06285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GA646_RS06290	COG1137	ATPase activity
GA646_RS06300	COG2274	protein secretion by the type I secretion system
GA646_RS06325	COG4122	O-methyltransferase activity
GA646_RS06335	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GA646_RS06360	COG1943	Transposase
GA646_RS06395	COG2011	ABC-type metal ion transport system permease component
GA646_RS06400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GA646_RS06420	COG0138	bifunctional purine biosynthesis protein purh
GA646_RS06425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GA646_RS06475	COG1305	Transglutaminase-like
GA646_RS06490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GA646_RS06495	COG0305	Participates in initiation and elongation during chromosome replication
GA646_RS06505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GA646_RS06510	COG0360	Binds together with S18 to 16S ribosomal RNA
GA646_RS06520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GA646_RS06525	COG1845	cytochrome c oxidase, subunit III
GA646_RS06530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GA646_RS06535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GA646_RS06560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA646_RS06575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GA646_RS06585	COG3781	membrane
GA646_RS06605	COG1960	acyl-CoA dehydrogenase activity
GA646_RS06610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GA646_RS06625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GA646_RS06635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GA646_RS06655	COG0477	Major facilitator Superfamily
GA646_RS06700	COG0786	glutamate:sodium symporter activity
GA646_RS06730	COG0308	aminopeptidase N
GA646_RS06740	COG0589	response to stress
GA646_RS06745	COG0589	response to stress
GA646_RS06755	COG3135	benzoate transporter
GA646_RS06765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GA646_RS06780	COG0183	Belongs to the thiolase family
GA646_RS06810	COG0824	Thioesterase
GA646_RS06815	COG1454	alcohol dehydrogenase
GA646_RS06820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GA646_RS06840	COG0069	glutamate synthase activity
GA646_RS06850	COG4585	Histidine kinase
GA646_RS06855	COG2850	peptidyl-arginine hydroxylation
GA646_RS06860	COG0424	maF-like protein
GA646_RS06885	COG0697	spore germination
GA646_RS06925	COG3698	Phosphodiester glycosidase
GA646_RS06945	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GA646_RS06945	COG0506	proline dehydrogenase activity
GA646_RS06945	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GA646_RS06955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA646_RS06960	COG1027	Aspartate ammonia-lyase
GA646_RS06965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GA646_RS06970	COG0583	DNA-binding transcription factor activity
GA646_RS06975	COG1960	acyl-CoA dehydrogenase activity
GA646_RS06995	COG1902	pentaerythritol trinitrate reductase activity
GA646_RS06995	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA646_RS07010	COG2814	Major facilitator Superfamily
GA646_RS07020	COG0583	DNA-binding transcription factor activity
GA646_RS07040	COG0148	phosphopyruvate hydratase activity
GA646_RS07055	COG0772	Belongs to the SEDS family
GA646_RS07070	COG2137	regulation of response to DNA damage stimulus
GA646_RS07080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GA646_RS07085	COG1011	Hydrolase
GA646_RS07090	COG1218	3'(2'),5'-bisphosphate nucleotidase
GA646_RS07110	COG3385	transposase activity
GA646_RS07120	COG0702	epimerase
GA646_RS07125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GA646_RS07140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GA646_RS07170	COG0316	Belongs to the HesB IscA family
GA646_RS07175	COG0822	iron-sulfur transferase activity
GA646_RS07205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GA646_RS07260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GA646_RS07280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GA646_RS07290	COG0133	tryptophan synthase activity
GA646_RS07295	COG0517	IMP dehydrogenase activity
GA646_RS07295	COG0516	GMP reductase activity
GA646_RS07325	COG0612	Peptidase, M16
GA646_RS07330	COG0552	protein localization to endoplasmic reticulum
GA646_RS07375	COG0693	protein deglycase activity
GA646_RS07385	COG1283	sodium-dependent phosphate transmembrane transporter activity
GA646_RS07395	COG1346	cytolysis
GA646_RS07405	COG0583	DNA-binding transcription factor activity
GA646_RS07430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GA646_RS07445	COG1629	transport
GA646_RS07460	COG1960	acyl-CoA dehydrogenase activity
GA646_RS07465	COG2207	Transcriptional regulator
GA646_RS07470	COG2814	Major facilitator Superfamily
GA646_RS07480	COG1271	oxidase subunit
GA646_RS07485	COG1294	oxidase, subunit
GA646_RS07495	COG1525	nuclease
GA646_RS07545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GA646_RS07550	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GA646_RS07565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GA646_RS07575	COG2814	Major facilitator Superfamily
GA646_RS07595	COG1132	(ABC) transporter
GA646_RS07610	COG0668	transmembrane transport
GA646_RS07615	COG3122	Protein conserved in bacteria
GA646_RS07635	COG0640	Transcriptional regulator
GA646_RS07640	COG2937	Belongs to the GPAT DAPAT family
GA646_RS07645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GA646_RS07650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GA646_RS07650	COG1116	anion transmembrane transporter activity
GA646_RS07660	COG2223	nitrite transmembrane transporter activity
GA646_RS07665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA646_RS07670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA646_RS07675	COG0243	molybdopterin cofactor binding
GA646_RS07685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GA646_RS07700	COG0521	Mo-molybdopterin cofactor biosynthetic process
GA646_RS07700	COG0315	cyclic pyranopterin monophosphate synthase activity
GA646_RS07705	COG0303	'Molybdopterin
GA646_RS07715	COG4149	molybdate abc transporter
GA646_RS07720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GA646_RS07725	COG0583	DNA-binding transcription factor activity
GA646_RS07745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA646_RS07750	COG0183	Belongs to the thiolase family
GA646_RS07755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GA646_RS07760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GA646_RS07765	COG3135	benzoate transporter
GA646_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS07775	COG0633	Ferredoxin
GA646_RS07775	COG0543	2 iron, 2 sulfur cluster binding
GA646_RS07780	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GA646_RS07785	COG4638	Rieske (2fe-2S)
GA646_RS07795	COG4829	muconolactone delta-isomerase
GA646_RS07800	COG4948	Mandelate Racemase Muconate Lactonizing
GA646_RS07805	COG0583	DNA-binding transcription factor activity
GA646_RS07810	COG2814	Major facilitator Superfamily
GA646_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS07850	COG2223	nitrite transmembrane transporter activity
GA646_RS07860	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GA646_RS07865	COG2116	formate transmembrane transporter activity
GA646_RS07870	COG0515	serine threonine protein kinase
GA646_RS07875	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GA646_RS07875	COG0644	oxidoreductase
GA646_RS07885	COG1960	acyl-CoA dehydrogenase activity
GA646_RS07890	COG1960	acyl-CoA dehydrogenase activity
GA646_RS07895	COG2814	Major facilitator Superfamily
GA646_RS07900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GA646_RS07905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GA646_RS07910	COG2814	Major facilitator Superfamily
GA646_RS07920	COG2814	Major facilitator Superfamily
GA646_RS07930	COG1250	3-hydroxyacyl-CoA dehydrogenase
GA646_RS07935	COG0183	Belongs to the thiolase family
GA646_RS07945	COG0235	Class ii aldolase
GA646_RS07950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GA646_RS07955	COG1024	Enoyl-CoA hydratase
GA646_RS07965	COG1960	acyl-CoA dehydrogenase activity
GA646_RS07970	COG0596	Alpha beta hydrolase
GA646_RS07970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA646_RS07970	COG2226	methyltransferase
GA646_RS07980	COG2814	Major facilitator Superfamily
GA646_RS07985	COG0318	PFAM AMP-dependent synthetase and ligase
GA646_RS07995	COG2814	Major facilitator Superfamily
GA646_RS08000	COG1846	Transcriptional regulator
GA646_RS08005	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS08010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GA646_RS08020	COG0318	PFAM AMP-dependent synthetase and ligase
GA646_RS08045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GA646_RS08050	COG1960	acyl-CoA dehydrogenase activity
GA646_RS08055	COG1024	Enoyl-CoA hydratase
GA646_RS08070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GA646_RS08075	COG1309	transcriptional regulator
GA646_RS08100	COG0745	RESPONSE REGULATOR receiver
GA646_RS08110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GA646_RS08125	COG2885	chlorophyll binding
GA646_RS08135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GA646_RS08140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GA646_RS08145	COG0730	response to heat
GA646_RS08165	COG1309	transcriptional regulator
GA646_RS08170	COG2801	Transposase and inactivated derivatives
GA646_RS08175	COG3328	transposase activity
GA646_RS08195	COG0596	Alpha beta hydrolase
GA646_RS08240	COG2433	Pfam Transposase IS66
GA646_RS08255	COG2963	transposase activity
GA646_RS08265	COG0511	ligase activity, forming carbon-carbon bonds
GA646_RS08270	COG0439	Biotin carboxylase
GA646_RS08285	COG2814	Major facilitator Superfamily
GA646_RS08335	COG1546	Belongs to the CinA family
GA646_RS08335	COG1058	Belongs to the CinA family
GA646_RS08345	COG0372	Belongs to the citrate synthase family
GA646_RS08365	COG0477	Major facilitator Superfamily
GA646_RS08380	COG0542	response to heat
GA646_RS08385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GA646_RS08405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GA646_RS08415	COG0569	domain protein
GA646_RS08420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GA646_RS08440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GA646_RS08450	COG1585	Membrane protein implicated in regulation of membrane protease activity
GA646_RS08465	COG1294	oxidase, subunit
GA646_RS08470	COG4890	Cyd operon protein YbgT
GA646_RS08505	COG1960	acyl-CoA dehydrogenase activity
GA646_RS08510	COG1960	acyl-CoA dehydrogenase activity
GA646_RS08520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GA646_RS08525	COG2207	Transcriptional regulator
GA646_RS08530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GA646_RS08535	COG0730	response to heat
GA646_RS08540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GA646_RS08570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GA646_RS08590	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GA646_RS08605	COG0575	Belongs to the CDS family
GA646_RS08610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GA646_RS08615	COG0233	cytoplasmic translational termination
GA646_RS08630	COG3852	Histidine kinase
GA646_RS08635	COG2204	response regulator
GA646_RS08645	COG0583	DNA-binding transcription factor activity
GA646_RS08650	COG0024	Methionine aminopeptidase
GA646_RS08675	COG1253	flavin adenine dinucleotide binding
GA646_RS08695	COG3385	transposase activity
GA646_RS08700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GA646_RS08705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GA646_RS08720	COG2431	L-lysine efflux transmembrane transporter activity
GA646_RS08725	COG0284	orotidine-5'-phosphate decarboxylase activity
GA646_RS08735	COG0776	regulation of translation
GA646_RS08755	COG0590	tRNA wobble adenosine to inosine editing
GA646_RS08765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GA646_RS08800	COG0084	hydrolase, TatD family'
GA646_RS08820	COG1663	tetraacyldisaccharide 4'-kinase activity
GA646_RS08825	COG1132	(ABC) transporter
GA646_RS08835	COG0811	peptide transport
GA646_RS08840	COG1475	DNA binding
GA646_RS08845	COG1192	Involved in chromosome partitioning
GA646_RS08855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GA646_RS08860	COG3178	'Phosphotransferase
GA646_RS08870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GA646_RS08875	COG1923	regulation of RNA biosynthetic process
GA646_RS08885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GA646_RS08890	COG0802	atpase or kinase
GA646_RS08915	COG2707	UPF0756 membrane protein
GA646_RS08925	COG0583	DNA-binding transcription factor activity
GA646_RS08930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GA646_RS08960	COG0519	Catalyzes the synthesis of GMP from XMP
GA646_RS08960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GA646_RS08965	COG2353	YceI-like domain
GA646_RS08975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GA646_RS08980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GA646_RS09015	COG1254	Belongs to the acylphosphatase family
GA646_RS09020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GA646_RS09020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GA646_RS09025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GA646_RS09045	COG0318	PFAM AMP-dependent synthetase and ligase
GA646_RS09050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GA646_RS09055	COG3327	negative regulation of DNA-templated transcription, initiation
GA646_RS09060	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GA646_RS09070	COG2814	Major facilitator Superfamily
GA646_RS09075	COG0783	Belongs to the Dps family
GA646_RS09090	COG5002	protein histidine kinase activity
GA646_RS09090	COG5001	Diguanylate cyclase
GA646_RS09100	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GA646_RS09120	COG4773	Receptor
GA646_RS09155	COG0579	oxidoreductase
GA646_RS09225	COG1074	ATP-dependent DNA helicase activity
GA646_RS09250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GA646_RS09260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GA646_RS09295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA646_RS09300	COG0508	dehydrogenase complex catalyzes the overall conversion of
GA646_RS09305	COG0022	dehydrogenase e1 component
GA646_RS09310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GA646_RS09315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GA646_RS09330	COG0204	Acyl-transferase
GA646_RS09355	COG0012	GTP binding
GA646_RS09365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GA646_RS09375	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GA646_RS09380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GA646_RS09390	COG0386	Belongs to the glutathione peroxidase family
GA646_RS09395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GA646_RS09400	COG0436	Aminotransferase
GA646_RS09405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GA646_RS09405	COG2755	lipolytic protein G-D-S-L family
GA646_RS09445	COG0515	serine threonine protein kinase
GA646_RS09445	COG2815	serine threonine protein kinase
GA646_RS09470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GA646_RS09475	COG1610	YqeY-like protein
GA646_RS09490	COG4783	chaperone-mediated protein folding
GA646_RS09555	COG0513	Belongs to the DEAD box helicase family
GA646_RS09575	COG2363	Small membrane protein
GA646_RS09595	COG0659	secondary active sulfate transmembrane transporter activity
GA646_RS09605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GA646_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
GA646_RS09630	COG1309	transcriptional regulator
GA646_RS09635	COG1960	acyl-CoA dehydrogenase activity
GA646_RS09640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GA646_RS09645	COG1024	Enoyl-CoA hydratase
GA646_RS09665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GA646_RS09680	COG0540	Belongs to the ATCase OTCase family
GA646_RS09700	COG1765	OsmC-like protein
GA646_RS09710	COG0667	Aldo Keto reductase
GA646_RS09725	COG0501	Belongs to the peptidase M48B family
GA646_RS09730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GA646_RS09745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GA646_RS09755	COG0527	aspartate kinase activity
GA646_RS09765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GA646_RS09775	COG1215	transferase activity, transferring glycosyl groups
GA646_RS09785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GA646_RS09790	COG2252	PERMEase
GA646_RS09815	COG4626	Terminase
GA646_RS09815	COG1802	Transcriptional regulator
GA646_RS09890	COG0714	Associated with various cellular activities
GA646_RS09895	COG2879	small protein
GA646_RS09900	COG1966	Carbon starvation protein
GA646_RS09905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GA646_RS09910	COG1509	lysine 2,3-aminomutase activity
GA646_RS09945	COG1067	ATP-dependent peptidase activity
GA646_RS09950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GA646_RS09955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GA646_RS09960	COG0583	DNA-binding transcription factor activity
GA646_RS09970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GA646_RS09985	COG1686	Belongs to the peptidase S11 family
GA646_RS09990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GA646_RS09995	COG1929	Belongs to the glycerate kinase type-1 family
GA646_RS10035	COG0616	signal peptide processing
GA646_RS10040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GA646_RS10050	COG0573	inorganic phosphate transmembrane transporter activity
GA646_RS10060	COG0076	glutamate decarboxylase activity
GA646_RS10065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GA646_RS10075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GA646_RS10085	COG2814	Major facilitator Superfamily
GA646_RS10090	COG1733	regulation of RNA biosynthetic process
GA646_RS10095	COG0702	epimerase
GA646_RS10125	COG0556	nucleotide-excision repair
GA646_RS10170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GA646_RS10175	COG1381	Involved in DNA repair and RecF pathway recombination
GA646_RS10185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GA646_RS10190	COG0571	ribonuclease III activity
GA646_RS10200	COG0681	Belongs to the peptidase S26 family
GA646_RS10215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GA646_RS10225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GA646_RS10240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GA646_RS10250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GA646_RS10265	COG4208	sulfate ABC transporter
GA646_RS10270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GA646_RS10275	COG0583	DNA-binding transcription factor activity
GA646_RS10295	COG0602	queuosine metabolic process
GA646_RS10300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GA646_RS10310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GA646_RS10315	COG2353	YceI-like domain
GA646_RS10320	COG1051	belongs to the nudix hydrolase family
GA646_RS10320	COG1056	cytidyltransferase-related domain
GA646_RS10325	COG1024	Enoyl-CoA hydratase
GA646_RS10330	COG0778	Nitroreductase
GA646_RS10345	COG0047	phosphoribosylformylglycinamidine synthase activity
GA646_RS10345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GA646_RS10365	COG2255	four-way junction helicase activity
GA646_RS10380	COG1473	amidohydrolase
GA646_RS10385	COG0824	Thioesterase
GA646_RS10405	COG0823	Involved in the tonB-independent uptake of proteins
GA646_RS10415	COG3385	transposase activity
GA646_RS10430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GA646_RS10460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GA646_RS10465	COG0628	permease
GA646_RS10470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GA646_RS10475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GA646_RS10495	COG0658	competence protein
GA646_RS10495	COG2333	competence protein COMEC
GA646_RS10500	COG1136	(ABC) transporter
GA646_RS10505	COG4591	ABC-type transport system involved in lipoprotein release permease component
GA646_RS10520	COG1671	Belongs to the UPF0178 family
GA646_RS10560	COG1280	lysine exporter protein (LysE YggA)
GA646_RS10565	COG1522	sequence-specific DNA binding
GA646_RS10575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GA646_RS10590	COG0019	diaminopimelate decarboxylase activity
GA646_RS10600	COG1113	amino acid transport
GA646_RS10605	COG1115	amino acid carrier protein
GA646_RS10625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GA646_RS10630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GA646_RS10665	COG0583	DNA-binding transcription factor activity
GA646_RS10675	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GA646_RS10690	COG0512	Glutamine amidotransferase of anthranilate synthase
GA646_RS10720	COG3706	GGDEF domain
GA646_RS10735	COG3739	integral membrane protein
GA646_RS10740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GA646_RS10750	COG1741	Belongs to the pirin family
GA646_RS10770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GA646_RS10775	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GA646_RS10785	COG0037	tRNA processing
GA646_RS10790	COG0739	heme binding
GA646_RS10790	COG0741	lytic transglycosylase activity
GA646_RS10790	COG1196	nuclear chromosome segregation
GA646_RS10795	COG0501	Belongs to the peptidase M48B family
GA646_RS10800	COG3385	transposase activity
GA646_RS10810	COG2239	Acts as a magnesium transporter
GA646_RS10845	COG1597	lipid kinase activity
GA646_RS10845	COG1803	Methylglyoxal synthase
GA646_RS10865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GA646_RS10925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GA646_RS10935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GA646_RS10945	COG1534	Rna-binding protein
GA646_RS10960	COG0505	Belongs to the CarA family
GA646_RS10975	COG1309	transcriptional regulator
GA646_RS10980	COG0251	oxidation-reduction process
GA646_RS10985	COG0110	maltose O-acetyltransferase activity
GA646_RS10990	COG0589	response to stress
GA646_RS11000	COG2321	neutral zinc metallopeptidase
GA646_RS11005	COG2354	Protein conserved in bacteria
GA646_RS11025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GA646_RS11035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA646_RS11050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GA646_RS11055	COG1053	succinate dehydrogenase
GA646_RS11060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GA646_RS11065	COG2009	succinate dehydrogenase
GA646_RS11075	COG2072	flavoprotein involved in K transport
GA646_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS11090	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GA646_RS11105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GA646_RS11105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GA646_RS11135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GA646_RS11145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GA646_RS11160	COG0564	pseudouridine synthase activity
GA646_RS11170	COG0358	DNA primase activity
GA646_RS11185	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GA646_RS11215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GA646_RS11235	COG3385	transposase activity
GA646_RS11260	COG0586	Pfam SNARE associated Golgi protein
GA646_RS11300	COG0321	lipoyl(octanoyl) transferase activity
GA646_RS11315	COG0531	amino acid
GA646_RS11320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GA646_RS11325	COG1648	precorrin-2 dehydrogenase activity
GA646_RS11325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GA646_RS11330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GA646_RS11340	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GA646_RS11365	COG0671	phosphoesterase, PA-phosphatase related
GA646_RS11370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA646_RS11380	COG1538	Outer membrane efflux protein
GA646_RS11385	COG0393	Putative heavy-metal-binding
GA646_RS11390	COG0393	Putative heavy-metal-binding
GA646_RS11395	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS11405	COG0525	valine-tRNA ligase activity
GA646_RS11415	COG0525	valine-tRNA ligase activity
GA646_RS11425	COG3328	transposase activity
GA646_RS11430	COG2852	Protein conserved in bacteria
GA646_RS11445	COG2323	membrane
GA646_RS11460	COG0765	amino acid transport
GA646_RS11465	COG0765	amino acid transport
GA646_RS11470	COG1126	abc transporter atp-binding protein
GA646_RS11475	COG3338	carbonate dehydratase activity
GA646_RS11490	COG1752	Esterase of the alpha-beta hydrolase superfamily
GA646_RS11505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA646_RS11510	COG2205	protein histidine kinase activity
GA646_RS11515	COG0745	RESPONSE REGULATOR receiver
GA646_RS11530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GA646_RS11535	COG1652	LysM domain
GA646_RS11545	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS11555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GA646_RS11560	COG1399	metal-binding, possibly nucleic acid-binding protein
GA646_RS11565	COG3101	peptidyl-lysine hydroxylation
GA646_RS11570	COG0009	L-threonylcarbamoyladenylate synthase
GA646_RS11585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GA646_RS11590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GA646_RS11605	COG4106	trans-aconitate 2-methyltransferase activity
GA646_RS11620	COG2226	methyltransferase
GA646_RS11620	COG0596	Alpha beta hydrolase
GA646_RS11620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA646_RS11625	COG2193	ferroxidase activity
GA646_RS11630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GA646_RS11635	COG3115	cell septum assembly
GA646_RS11640	COG1196	nuclear chromosome segregation
GA646_RS11650	COG0730	response to heat
GA646_RS11670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GA646_RS11695	COG2801	Transposase and inactivated derivatives
GA646_RS11720	COG2824	Alkylphosphonate utilization operon protein PhnA
GA646_RS11725	COG3189	MarR family transcriptional regulator
GA646_RS11740	COG0564	pseudouridine synthase activity
GA646_RS11745	COG0346	lactoylglutathione lyase activity
GA646_RS11775	COG0354	folic acid binding
GA646_RS11805	COG0363	glucosamine-6-phosphate deaminase activity
GA646_RS11840	COG1877	trehalose-phosphatase activity
GA646_RS11850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GA646_RS11855	COG1970	mechanosensitive ion channel activity
GA646_RS11865	COG2233	PERMEase
GA646_RS11875	COG0833	amino acid
GA646_RS11885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GA646_RS11885	COG2885	chlorophyll binding
GA646_RS11895	COG0183	Belongs to the thiolase family
GA646_RS11910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA646_RS11920	COG2207	Transcriptional regulator
GA646_RS11925	COG0183	Belongs to the thiolase family
GA646_RS11930	COG1250	3-hydroxyacyl-CoA dehydrogenase
GA646_RS11930	COG1024	Enoyl-CoA hydratase
GA646_RS11950	COG1272	protein, Hemolysin III
GA646_RS11955	COG0477	Major facilitator Superfamily
GA646_RS11965	COG1408	metallophosphoesterase
GA646_RS11970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GA646_RS11980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GA646_RS12010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GA646_RS12015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GA646_RS12020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GA646_RS12030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GA646_RS12035	COG0625	glutathione transferase activity
GA646_RS12040	COG2969	positive regulation of protein catabolic process
GA646_RS12105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GA646_RS12150	COG0037	tRNA processing
GA646_RS12160	COG0248	Ppx GppA phosphatase
GA646_RS12185	COG0072	phenylalanine-tRNA ligase activity
GA646_RS12205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GA646_RS12220	COG1238	metal cluster binding
GA646_RS12225	COG0625	glutathione transferase activity
GA646_RS12240	COG0318	PFAM AMP-dependent synthetase and ligase
GA646_RS12245	COG3028	Belongs to the UPF0307 family
GA646_RS12255	COG1660	Displays ATPase and GTPase activities
GA646_RS12270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GA646_RS12275	COG0617	tRNA 3'-terminal CCA addition
GA646_RS12280	COG1555	photosystem II stabilization
GA646_RS12285	COG3956	TIGRFAM MazG family protein
GA646_RS12300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GA646_RS12310	COG0124	histidyl-tRNA synthetase
GA646_RS12340	COG2975	iron-sulfur cluster assembly
GA646_RS12390	COG0440	acetolactate synthase activity
GA646_RS12395	COG0028	Belongs to the TPP enzyme family
GA646_RS12410	COG3328	transposase activity
GA646_RS12445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA646_RS12450	COG1136	(ABC) transporter
GA646_RS12450	COG0577	efflux transmembrane transporter activity
GA646_RS12475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GA646_RS12480	COG1162	GTPase activity
GA646_RS12490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GA646_RS12500	COG3385	transposase activity
GA646_RS12505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GA646_RS12515	COG3781	membrane
GA646_RS12520	COG0613	PHP domain protein
GA646_RS12530	COG2350	Protein conserved in bacteria
GA646_RS12550	COG1666	GTP binding
GA646_RS12560	COG1607	acyl-coa hydrolase
GA646_RS12575	COG3453	Protein conserved in bacteria
GA646_RS12575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GA646_RS12620	COG1183	phosphatidylcholine synthase activity
GA646_RS12625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GA646_RS12665	COG0741	lytic transglycosylase activity
GA646_RS12665	COG1196	nuclear chromosome segregation
GA646_RS12665	COG0739	heme binding
GA646_RS12670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GA646_RS12675	COG1702	phosphate starvation-inducible protein PhoH
GA646_RS12725	COG1295	ribonuclease BN
GA646_RS12755	COG0788	formyltetrahydrofolate deformylase activity
GA646_RS12770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GA646_RS12775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GA646_RS12780	COG4651	solute:proton antiporter activity
GA646_RS12780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GA646_RS12795	COG0724	RNA recognition motif
GA646_RS12800	COG0210	DNA helicase
GA646_RS12810	COG1929	Belongs to the glycerate kinase type-1 family
GA646_RS12850	COG1560	Kdo2-lipid A biosynthetic process
GA646_RS12910	COG0473	3-isopropylmalate dehydrogenase activity
GA646_RS12925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GA646_RS12955	COG0494	nUDIX hydrolase
GA646_RS12985	COG0753	catalase activity
GA646_RS13000	COG4372	Transposase
GA646_RS13010	COG2963	transposase activity
GA646_RS13015	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA646_RS13020	COG3384	dioxygenase
GA646_RS13025	COG1028	Short-chain dehydrogenase reductase Sdr
GA646_RS13040	COG4638	Rieske (2fe-2S)
GA646_RS13045	COG0583	DNA-binding transcription factor activity
GA646_RS13070	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GA646_RS13075	COG3971	2-oxopent-4-enoate hydratase activity
GA646_RS13080	COG0546	phosphoglycolate phosphatase activity
GA646_RS13090	COG1530	ribonuclease E activity
GA646_RS13120	COG1983	PspC domain protein
GA646_RS13135	COG0751	glycine-tRNA ligase activity
GA646_RS13160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GA646_RS13175	COG2226	methyltransferase
GA646_RS13185	COG0493	'glutamate synthase
GA646_RS13185	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GA646_RS13195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GA646_RS13205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GA646_RS13220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GA646_RS13230	COG0644	oxidoreductase
GA646_RS13230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GA646_RS13240	COG0425	Belongs to the sulfur carrier protein TusA family
GA646_RS13245	COG4535	Mg2 and Co2 transporter CorC
GA646_RS13250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GA646_RS13270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GA646_RS13280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GA646_RS13290	COG0789	Transcriptional regulator
GA646_RS13295	COG2841	Protein conserved in bacteria
GA646_RS13310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GA646_RS13315	COG0675	Transposase, IS605 OrfB family
GA646_RS13320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GA646_RS13325	COG1074	ATP-dependent DNA helicase activity
GA646_RS13330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GA646_RS13360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GA646_RS13370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GA646_RS13385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GA646_RS13385	COG2111	Na H antiporter
GA646_RS13390	COG1006	Multisubunit Na H antiporter MnhC subunit
GA646_RS13395	COG0651	ATP synthesis coupled electron transport
GA646_RS13405	COG2212	antiporter activity
GA646_RS13415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GA646_RS13425	COG0195	Participates in both transcription termination and antitermination
GA646_RS13430	COG0779	Required for maturation of 30S ribosomal subunits
GA646_RS13480	COG0237	dephospho-CoA kinase activity
GA646_RS13490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GA646_RS13495	COG3123	guanosine phosphorylase activity
GA646_RS13500	COG0497	DNA recombination
GA646_RS13510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GA646_RS13525	COG1132	(ABC) transporter
GA646_RS13530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GA646_RS13560	COG1024	Enoyl-CoA hydratase
GA646_RS13560	COG1250	3-hydroxyacyl-CoA dehydrogenase
GA646_RS13570	COG2233	PERMEase
GA646_RS13580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GA646_RS13605	COG0326	Molecular chaperone. Has ATPase activity
GA646_RS13620	COG2056	Na+-H+ antiporter family
GA646_RS13640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GA646_RS13645	COG0085	RNA polymerase activity
GA646_RS13660	COG0081	regulation of translation
GA646_RS13745	COG0824	Thioesterase
GA646_RS13765	COG0181	hydroxymethylbilane synthase activity
GA646_RS13775	COG3275	phosphorelay sensor kinase activity
GA646_RS13810	COG0494	nUDIX hydrolase
GA646_RS13815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GA646_RS13820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GA646_RS13825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GA646_RS13835	COG0772	Belongs to the SEDS family
GA646_RS13860	COG4974	Belongs to the 'phage' integrase family
GA646_RS13875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GA646_RS13885	COG2197	response regulator
GA646_RS13900	COG0793	Belongs to the peptidase S41A family
GA646_RS13905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GA646_RS13910	COG0795	lipopolysaccharide-transporting ATPase activity
GA646_RS13915	COG0795	lipopolysaccharide-transporting ATPase activity
GA646_RS13940	COG0586	Pfam SNARE associated Golgi protein
GA646_RS13955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GA646_RS13955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GA646_RS13965	COG0004	ammonium transporteR
GA646_RS13970	COG0347	Belongs to the P(II) protein family
GA646_RS13995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GA646_RS14010	COG0318	PFAM AMP-dependent synthetase and ligase
GA646_RS14020	COG0477	Major facilitator Superfamily
GA646_RS14025	COG2860	membrane
GA646_RS14035	COG1253	flavin adenine dinucleotide binding
GA646_RS14060	COG2814	Major facilitator Superfamily
GA646_RS14075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GA646_RS14095	COG2814	Major facilitator Superfamily
GA646_RS14145	COG0758	DNA mediated transformation
GA646_RS14155	COG0697	spore germination
GA646_RS14160	COG0386	Belongs to the glutathione peroxidase family
GA646_RS14180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GA646_RS14190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GA646_RS14230	COG1121	(ABC) transporter
GA646_RS14235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GA646_RS14245	COG2837	iron assimilation
GA646_RS14250	COG0281	malic enzyme
GA646_RS14285	COG0745	RESPONSE REGULATOR receiver
GA646_RS14285	COG3706	GGDEF domain
GA646_RS14290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GA646_RS14290	COG0519	Catalyzes the synthesis of GMP from XMP
GA646_RS14295	COG2259	Doxx family
GA646_RS14300	COG0586	Pfam SNARE associated Golgi protein
GA646_RS14315	COG1192	Involved in chromosome partitioning
GA646_RS14325	COG0271	Belongs to the BolA IbaG family
GA646_RS14360	COG3756	Protein conserved in bacteria
GA646_RS14440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GA646_RS14460	COG3316	Transposase and inactivated derivatives
GA646_RS14485	COG1064	alcohol dehydrogenase
GA646_RS14580	COG3550	peptidyl-serine autophosphorylation
GA646_RS14585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GA646_RS14595	COG4115	mRNA cleavage
GA646_RS14610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GA646_RS14625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GA646_RS14635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GA646_RS14655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GA646_RS14665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GA646_RS14675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GA646_RS14685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GA646_RS14695	COG1086	Polysaccharide biosynthesis protein
GA646_RS14740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GA646_RS14745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GA646_RS14750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GA646_RS14805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GA646_RS14820	COG2233	PERMEase
GA646_RS14835	COG0129	dihydroxy-acid dehydratase activity
GA646_RS14845	COG3385	transposase activity
GA646_RS14860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GA646_RS14870	COG0733	neurotransmitter:sodium symporter activity
GA646_RS14875	COG1012	belongs to the aldehyde dehydrogenase family
GA646_RS14885	COG1943	Transposase
GA646_RS14895	COG2814	Major facilitator Superfamily
GA646_RS14925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GA646_RS14970	COG2951	lytic endotransglycosylase activity
GA646_RS14980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GA646_RS15000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GA646_RS15010	COG1943	Transposase
GA646_RS15020	COG2388	GCN5-related N-acetyl-transferase
GA646_RS15030	COG0861	Integral membrane protein TerC family
GA646_RS15035	COG3385	transposase activity
GA646_RS15040	COG0402	S-adenosylhomocysteine deaminase activity
GA646_RS15055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GA646_RS15085	COG0706	membrane insertase activity
GA646_RS15090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GA646_RS15095	COG0594	ribonuclease P activity
GA646_RS15100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GA646_RS15125	COG3316	Transposase and inactivated derivatives
GA646_RS15160	COG4974	Belongs to the 'phage' integrase family
GA646_RS15190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GA646_RS15205	COG3316	Transposase and inactivated derivatives
GA646_RS15220	COG2826	transposase and inactivated derivatives, IS30 family
GA646_RS15240	COG0673	inositol 2-dehydrogenase activity
GA646_RS15290	COG2801	Transposase and inactivated derivatives
GA646_RS15360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GA646_RS15370	COG4372	Transposase
GA646_RS15385	COG4372	Transposase
GA646_RS15400	COG4372	Transposase
GA646_RS15430	COG4372	Transposase
GA646_RS15460	COG2369	cell adhesion
GA646_RS15465	COG0582	viral genome integration into host DNA
GA646_RS15500	COG4372	Transposase
GA646_RS15595	COG1373	ATPase (AAA superfamily