locus-tag	class	description
E5093_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5093_RS00015	COG0594	ribonuclease P activity
E5093_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5093_RS00025	COG0706	membrane insertase activity
E5093_RS00050	COG1230	cation diffusion facilitator family transporter
E5093_RS00055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5093_RS00075	COG0402	S-adenosylhomocysteine deaminase activity
E5093_RS00080	COG0861	Integral membrane protein TerC family
E5093_RS00090	COG2388	GCN5-related N-acetyl-transferase
E5093_RS00100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5093_RS00120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5093_RS00130	COG2951	lytic endotransglycosylase activity
E5093_RS00180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5093_RS00210	COG2814	Major facilitator Superfamily
E5093_RS00220	COG1012	belongs to the aldehyde dehydrogenase family
E5093_RS00225	COG0733	neurotransmitter:sodium symporter activity
E5093_RS00235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5093_RS00250	COG0129	dihydroxy-acid dehydratase activity
E5093_RS00270	COG2233	PERMEase
E5093_RS00280	COG1309	transcriptional regulator
E5093_RS00285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_RS00340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5093_RS00385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5093_RS00395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5093_RS00405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5093_RS00420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5093_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5093_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5093_RS00455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5093_RS00485	COG1518	maintenance of DNA repeat elements
E5093_RS00530	COG1337	RAMP superfamily
E5093_RS00655	COG0556	nucleotide-excision repair
E5093_RS00660	COG1104	cysteine desulfurase activity
E5093_RS00670	COG3756	Protein conserved in bacteria
E5093_RS00705	COG0271	Belongs to the BolA IbaG family
E5093_RS00715	COG1192	Involved in chromosome partitioning
E5093_RS00730	COG0586	Pfam SNARE associated Golgi protein
E5093_RS00735	COG2259	Doxx family
E5093_RS00740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5093_RS00740	COG0519	Catalyzes the synthesis of GMP from XMP
E5093_RS00780	COG0281	malic enzyme
E5093_RS00785	COG3501	Rhs element vgr protein
E5093_RS00800	COG2837	iron assimilation
E5093_RS00810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5093_RS00815	COG1121	(ABC) transporter
E5093_RS00865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5093_RS00895	COG0386	Belongs to the glutathione peroxidase family
E5093_RS00900	COG0697	spore germination
E5093_RS00910	COG0758	DNA mediated transformation
E5093_RS00960	COG2814	Major facilitator Superfamily
E5093_RS00980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5093_RS00995	COG2814	Major facilitator Superfamily
E5093_RS01015	COG1253	flavin adenine dinucleotide binding
E5093_RS01025	COG2860	membrane
E5093_RS01030	COG0477	Major facilitator Superfamily
E5093_RS01040	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_RS01055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5093_RS01080	COG0347	Belongs to the P(II) protein family
E5093_RS01085	COG0004	ammonium transporteR
E5093_RS01095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5093_RS01095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5093_RS01110	COG0586	Pfam SNARE associated Golgi protein
E5093_RS01135	COG0795	lipopolysaccharide-transporting ATPase activity
E5093_RS01140	COG0795	lipopolysaccharide-transporting ATPase activity
E5093_RS01145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5093_RS01150	COG0793	Belongs to the peptidase S41A family
E5093_RS01165	COG2197	response regulator
E5093_RS01175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5093_RS01190	COG4974	Belongs to the 'phage' integrase family
E5093_RS01215	COG0772	Belongs to the SEDS family
E5093_RS01225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5093_RS01230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5093_RS01235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5093_RS01240	COG0494	nUDIX hydrolase
E5093_RS01275	COG3275	phosphorelay sensor kinase activity
E5093_RS01285	COG0181	hydroxymethylbilane synthase activity
E5093_RS01305	COG0824	Thioesterase
E5093_RS01390	COG0081	regulation of translation
E5093_RS01405	COG0085	RNA polymerase activity
E5093_RS01410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5093_RS01430	COG2056	Na+-H+ antiporter family
E5093_RS01445	COG0326	Molecular chaperone. Has ATPase activity
E5093_RS01475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5093_RS01485	COG2233	PERMEase
E5093_RS01495	COG1024	Enoyl-CoA hydratase
E5093_RS01495	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_RS01525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5093_RS01530	COG1132	(ABC) transporter
E5093_RS01545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5093_RS01555	COG0497	DNA recombination
E5093_RS01560	COG3123	guanosine phosphorylase activity
E5093_RS01565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5093_RS01575	COG0237	dephospho-CoA kinase activity
E5093_RS01625	COG0779	Required for maturation of 30S ribosomal subunits
E5093_RS01630	COG0195	Participates in both transcription termination and antitermination
E5093_RS01640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5093_RS01650	COG2212	antiporter activity
E5093_RS01660	COG0651	ATP synthesis coupled electron transport
E5093_RS01665	COG1006	Multisubunit Na H antiporter MnhC subunit
E5093_RS01670	COG2111	Na H antiporter
E5093_RS01670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5093_RS01685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5093_RS01695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5093_RS01725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5093_RS01730	COG1074	ATP-dependent DNA helicase activity
E5093_RS01735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5093_RS01745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5093_RS01760	COG2841	Protein conserved in bacteria
E5093_RS01765	COG0789	Transcriptional regulator
E5093_RS01775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5093_RS01785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5093_RS01805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5093_RS01810	COG4535	Mg2 and Co2 transporter CorC
E5093_RS01815	COG0425	Belongs to the sulfur carrier protein TusA family
E5093_RS01820	COG3501	Rhs element vgr protein
E5093_RS01845	COG0644	oxidoreductase
E5093_RS01845	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5093_RS01855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5093_RS01870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5093_RS01880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5093_RS01890	COG0493	'glutamate synthase
E5093_RS01890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5093_RS01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5093_RS01945	COG0751	glycine-tRNA ligase activity
E5093_RS01955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5093_RS01955	COG0617	tRNA 3'-terminal CCA addition
E5093_RS01955	COG0517	IMP dehydrogenase activity
E5093_RS01960	COG1983	PspC domain protein
E5093_RS01985	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_RS01990	COG1530	ribonuclease E activity
E5093_RS02000	COG0546	phosphoglycolate phosphatase activity
E5093_RS02005	COG3971	2-oxopent-4-enoate hydratase activity
E5093_RS02010	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E5093_RS02035	COG0583	DNA-binding transcription factor activity
E5093_RS02040	COG4638	Rieske (2fe-2S)
E5093_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS02060	COG3384	dioxygenase
E5093_RS02065	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5093_RS02080	COG0753	catalase activity
E5093_RS02090	COG1960	acyl-CoA dehydrogenase activity
E5093_RS02110	COG0494	nUDIX hydrolase
E5093_RS02125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5093_RS02140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5093_RS02155	COG0473	3-isopropylmalate dehydrogenase activity
E5093_RS02205	COG1560	Kdo2-lipid A biosynthetic process
E5093_RS02215	COG2900	Belongs to the SlyX family
E5093_RS02245	COG1929	Belongs to the glycerate kinase type-1 family
E5093_RS02255	COG0210	DNA helicase
E5093_RS02260	COG0724	RNA recognition motif
E5093_RS02275	COG4651	solute:proton antiporter activity
E5093_RS02275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5093_RS02300	COG0788	formyltetrahydrofolate deformylase activity
E5093_RS02330	COG1295	ribonuclease BN
E5093_RS02380	COG1702	phosphate starvation-inducible protein PhoH
E5093_RS02390	COG1196	nuclear chromosome segregation
E5093_RS02390	COG0739	heme binding
E5093_RS02390	COG0741	lytic transglycosylase activity
E5093_RS02430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5093_RS02435	COG1183	phosphatidylcholine synthase activity
E5093_RS02500	COG1607	acyl-coa hydrolase
E5093_RS02510	COG1666	GTP binding
E5093_RS02530	COG2350	Protein conserved in bacteria
E5093_RS02540	COG0613	PHP domain protein
E5093_RS02545	COG3781	membrane
E5093_RS02555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5093_RS02565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5093_RS02575	COG1162	GTPase activity
E5093_RS02580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5093_RS02595	COG3501	Rhs element vgr protein
E5093_RS02620	COG0577	efflux transmembrane transporter activity
E5093_RS02620	COG1136	(ABC) transporter
E5093_RS02625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_RS02650	COG0028	Belongs to the TPP enzyme family
E5093_RS02655	COG0440	acetolactate synthase activity
E5093_RS02695	COG2975	iron-sulfur cluster assembly
E5093_RS02725	COG0124	histidyl-tRNA synthetase
E5093_RS02735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5093_RS02750	COG3956	TIGRFAM MazG family protein
E5093_RS02755	COG1555	photosystem II stabilization
E5093_RS02760	COG0617	tRNA 3'-terminal CCA addition
E5093_RS02765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5093_RS02780	COG1660	Displays ATPase and GTPase activities
E5093_RS02790	COG3028	Belongs to the UPF0307 family
E5093_RS02795	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_RS02810	COG0625	glutathione transferase activity
E5093_RS02815	COG1238	metal cluster binding
E5093_RS02850	COG0072	phenylalanine-tRNA ligase activity
E5093_RS02875	COG0248	Ppx GppA phosphatase
E5093_RS02885	COG0037	tRNA processing
E5093_RS02930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5093_RS02980	COG2969	positive regulation of protein catabolic process
E5093_RS02985	COG0625	glutathione transferase activity
E5093_RS02990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5093_RS03000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5093_RS03005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5093_RS03010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5093_RS03045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5093_RS03055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5093_RS03060	COG1408	metallophosphoesterase
E5093_RS03070	COG0477	Major facilitator Superfamily
E5093_RS03075	COG1272	protein, Hemolysin III
E5093_RS03095	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_RS03095	COG1024	Enoyl-CoA hydratase
E5093_RS03100	COG0183	Belongs to the thiolase family
E5093_RS03105	COG2207	Transcriptional regulator
E5093_RS03115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_RS03130	COG0183	Belongs to the thiolase family
E5093_RS03150	COG0833	amino acid
E5093_RS03160	COG2233	PERMEase
E5093_RS03170	COG1970	mechanosensitive ion channel activity
E5093_RS03175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5093_RS03185	COG1877	trehalose-phosphatase activity
E5093_RS03190	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5093_RS03200	COG0363	glucosamine-6-phosphate deaminase activity
E5093_RS03230	COG0354	folic acid binding
E5093_RS03260	COG0346	lactoylglutathione lyase activity
E5093_RS03265	COG0564	pseudouridine synthase activity
E5093_RS03280	COG3189	MarR family transcriptional regulator
E5093_RS03285	COG2824	Alkylphosphonate utilization operon protein PhnA
E5093_RS03295	COG0628	permease
E5093_RS03310	COG1764	response to oxidative stress
E5093_RS03315	COG1846	Transcriptional regulator
E5093_RS03320	COG2801	Transposase and inactivated derivatives
E5093_RS03335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5093_RS03355	COG0730	response to heat
E5093_RS03365	COG1196	nuclear chromosome segregation
E5093_RS03370	COG3115	cell septum assembly
E5093_RS03375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5093_RS03380	COG2193	ferroxidase activity
E5093_RS03385	COG2226	methyltransferase
E5093_RS03385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_RS03385	COG0596	Alpha beta hydrolase
E5093_RS03400	COG4106	trans-aconitate 2-methyltransferase activity
E5093_RS03415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5093_RS03420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5093_RS03430	COG0009	L-threonylcarbamoyladenylate synthase
E5093_RS03435	COG3101	peptidyl-lysine hydroxylation
E5093_RS03440	COG1399	metal-binding, possibly nucleic acid-binding protein
E5093_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS03465	COG1652	LysM domain
E5093_RS03475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5093_RS03490	COG0745	RESPONSE REGULATOR receiver
E5093_RS03495	COG2205	protein histidine kinase activity
E5093_RS03500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5093_RS03515	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5093_RS03530	COG3338	carbonate dehydratase activity
E5093_RS03535	COG1126	abc transporter atp-binding protein
E5093_RS03540	COG0765	amino acid transport
E5093_RS03545	COG0765	amino acid transport
E5093_RS03555	COG2323	membrane
E5093_RS03570	COG2852	Protein conserved in bacteria
E5093_RS03580	COG0525	valine-tRNA ligase activity
E5093_RS03595	COG0393	Putative heavy-metal-binding
E5093_RS03600	COG0393	Putative heavy-metal-binding
E5093_RS03610	COG1538	Outer membrane efflux protein
E5093_RS03620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_RS03625	COG0671	phosphoesterase, PA-phosphatase related
E5093_RS03650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5093_RS03660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5093_RS03665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5093_RS03665	COG1648	precorrin-2 dehydrogenase activity
E5093_RS03670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5093_RS03675	COG0531	amino acid
E5093_RS03690	COG0321	lipoyl(octanoyl) transferase activity
E5093_RS03725	COG0586	Pfam SNARE associated Golgi protein
E5093_RS03765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5093_RS03795	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5093_RS03810	COG0358	DNA primase activity
E5093_RS03820	COG0564	pseudouridine synthase activity
E5093_RS03835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5093_RS03845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5093_RS03875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5093_RS03875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5093_RS03890	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E5093_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS03905	COG2072	flavoprotein involved in K transport
E5093_RS03920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5093_RS03925	COG1053	succinate dehydrogenase
E5093_RS03930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5093_RS03945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5093_RS03955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5093_RS03965	COG1649	PFAM Uncharacterised BCR, COG1649
E5093_RS03965	COG0726	polysaccharide deacetylase
E5093_RS03970	COG1215	transferase activity, transferring glycosyl groups
E5093_RS03980	COG2268	Band 7 protein
E5093_RS03995	COG2354	Protein conserved in bacteria
E5093_RS04000	COG2321	neutral zinc metallopeptidase
E5093_RS04010	COG0589	response to stress
E5093_RS04015	COG0110	maltose O-acetyltransferase activity
E5093_RS04020	COG0415	Belongs to the DNA photolyase family
E5093_RS04035	COG0505	Belongs to the CarA family
E5093_RS04050	COG1534	Rna-binding protein
E5093_RS04060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5093_RS04070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5093_RS04105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5093_RS04125	COG1597	lipid kinase activity
E5093_RS04150	COG0584	glycerophosphoryl diester phosphodiesterase
E5093_RS04160	COG2239	Acts as a magnesium transporter
E5093_RS04170	COG0501	Belongs to the peptidase M48B family
E5093_RS04175	COG0741	lytic transglycosylase activity
E5093_RS04175	COG0739	heme binding
E5093_RS04175	COG1196	nuclear chromosome segregation
E5093_RS04180	COG0037	tRNA processing
E5093_RS04190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E5093_RS04195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5093_RS04265	COG1484	DNA-dependent DNA replication
E5093_RS04270	COG4584	PFAM Integrase catalytic
E5093_RS04315	COG3621	Patatin-like phospholipase
E5093_RS04360	COG1840	ABC-type Fe3 transport system, periplasmic component
E5093_RS04365	COG3842	ATPase activity
E5093_RS04370	COG1741	Belongs to the pirin family
E5093_RS04380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5093_RS04385	COG3739	integral membrane protein
E5093_RS04400	COG3706	GGDEF domain
E5093_RS04435	COG0512	Glutamine amidotransferase of anthranilate synthase
E5093_RS04440	COG0174	glutamine synthetase
E5093_RS04450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5093_RS04495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5093_RS04500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5093_RS04520	COG1115	amino acid carrier protein
E5093_RS04525	COG1113	amino acid transport
E5093_RS04535	COG0019	diaminopimelate decarboxylase activity
E5093_RS04550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5093_RS04560	COG1522	sequence-specific DNA binding
E5093_RS04565	COG1280	lysine exporter protein (LysE YggA)
E5093_RS04610	COG1671	Belongs to the UPF0178 family
E5093_RS04625	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5093_RS04630	COG1136	(ABC) transporter
E5093_RS04635	COG2333	competence protein COMEC
E5093_RS04635	COG0658	competence protein
E5093_RS04655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5093_RS04660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5093_RS04665	COG0628	permease
E5093_RS04670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5093_RS04700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5093_RS04720	COG0823	Involved in the tonB-independent uptake of proteins
E5093_RS04740	COG0824	Thioesterase
E5093_RS04750	COG2255	four-way junction helicase activity
E5093_RS04770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5093_RS04770	COG0047	phosphoribosylformylglycinamidine synthase activity
E5093_RS04785	COG0778	Nitroreductase
E5093_RS04790	COG1024	Enoyl-CoA hydratase
E5093_RS04795	COG1051	belongs to the nudix hydrolase family
E5093_RS04795	COG1056	cytidyltransferase-related domain
E5093_RS04800	COG2353	YceI-like domain
E5093_RS04805	COG0583	DNA-binding transcription factor activity
E5093_RS04815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5093_RS04825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5093_RS04830	COG0602	queuosine metabolic process
E5093_RS04850	COG0583	DNA-binding transcription factor activity
E5093_RS04855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5093_RS04860	COG4208	sulfate ABC transporter
E5093_RS04875	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5093_RS04885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5093_RS04900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5093_RS04910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5093_RS04925	COG0681	Belongs to the peptidase S26 family
E5093_RS04935	COG0571	ribonuclease III activity
E5093_RS04940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5093_RS04950	COG1381	Involved in DNA repair and RecF pathway recombination
E5093_RS04955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5093_RS04975	COG0436	Aminotransferase
E5093_RS04995	COG0556	nucleotide-excision repair
E5093_RS05025	COG0702	epimerase
E5093_RS05030	COG1733	regulation of RNA biosynthetic process
E5093_RS05035	COG2814	Major facilitator Superfamily
E5093_RS05045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5093_RS05050	COG0582	viral genome integration into host DNA
E5093_RS05100	COG0642	Histidine kinase
E5093_RS05105	COG0745	RESPONSE REGULATOR receiver
E5093_RS05110	COG2194	sulfuric ester hydrolase activity
E5093_RS05170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5093_RS05175	COG0076	glutamate decarboxylase activity
E5093_RS05185	COG0573	inorganic phosphate transmembrane transporter activity
E5093_RS05195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5093_RS05200	COG0616	signal peptide processing
E5093_RS05255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5093_RS05260	COG1686	Belongs to the peptidase S11 family
E5093_RS05275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5093_RS05285	COG0583	DNA-binding transcription factor activity
E5093_RS05290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5093_RS05295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5093_RS05300	COG1067	ATP-dependent peptidase activity
E5093_RS05335	COG1509	lysine 2,3-aminomutase activity
E5093_RS05340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5093_RS05345	COG1966	Carbon starvation protein
E5093_RS05350	COG2879	small protein
E5093_RS05355	COG0714	Associated with various cellular activities
E5093_RS05385	COG2252	PERMEase
E5093_RS05390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5093_RS05400	COG1215	transferase activity, transferring glycosyl groups
E5093_RS05410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5093_RS05420	COG0527	aspartate kinase activity
E5093_RS05430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5093_RS05445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5093_RS05450	COG0501	Belongs to the peptidase M48B family
E5093_RS05465	COG0667	Aldo Keto reductase
E5093_RS05475	COG1765	OsmC-like protein
E5093_RS05505	COG0540	Belongs to the ATCase OTCase family
E5093_RS05520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_RS05535	COG4770	biotin carboxylase activity
E5093_RS05540	COG1024	Enoyl-CoA hydratase
E5093_RS05545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5093_RS05550	COG1960	acyl-CoA dehydrogenase activity
E5093_RS05555	COG1309	transcriptional regulator
E5093_RS05560	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_RS05580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5093_RS05590	COG0659	secondary active sulfate transmembrane transporter activity
E5093_RS05610	COG2363	Small membrane protein
E5093_RS05630	COG0513	Belongs to the DEAD box helicase family
E5093_RS05695	COG4783	chaperone-mediated protein folding
E5093_RS05710	COG1610	YqeY-like protein
E5093_RS05740	COG2815	serine threonine protein kinase
E5093_RS05740	COG0515	serine threonine protein kinase
E5093_RS05785	COG0436	Aminotransferase
E5093_RS05790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5093_RS05795	COG0386	Belongs to the glutathione peroxidase family
E5093_RS05805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5093_RS05820	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5093_RS05830	COG0012	GTP binding
E5093_RS05855	COG0204	Acyl-transferase
E5093_RS05895	COG3706	GGDEF domain
E5093_RS05910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5093_RS05925	COG1414	Transcriptional regulator
E5093_RS05930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5093_RS05935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_RS05940	COG0183	Belongs to the thiolase family
E5093_RS05945	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5093_RS05950	COG0596	Alpha beta hydrolase
E5093_RS05980	COG2351	hydroxyisourate hydrolase activity
E5093_RS05995	COG3046	protein related to deoxyribodipyrimidine photolyase
E5093_RS06000	COG2816	NAD+ diphosphatase activity
E5093_RS06025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5093_RS06040	COG0642	Histidine kinase
E5093_RS06045	COG0745	RESPONSE REGULATOR receiver
E5093_RS06075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5093_RS06105	COG4773	Receptor
E5093_RS06125	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
E5093_RS06135	COG5001	Diguanylate cyclase
E5093_RS06135	COG5002	protein histidine kinase activity
E5093_RS06150	COG0783	Belongs to the Dps family
E5093_RS06155	COG2814	Major facilitator Superfamily
E5093_RS06160	COG1012	belongs to the aldehyde dehydrogenase family
E5093_RS06160	COG2030	dehydratase
E5093_RS06165	COG3396	Phenylacetate-CoA oxygenase
E5093_RS06170	COG3460	Phenylacetate-CoA oxygenase
E5093_RS06175	COG3396	Phenylacetate-CoA oxygenase
E5093_RS06180	COG2151	metal-sulfur cluster biosynthetic enzyme
E5093_RS06185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5093_RS06190	COG1024	Enoyl-CoA hydratase
E5093_RS06195	COG1024	Enoyl-CoA hydratase
E5093_RS06200	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_RS06205	COG0183	Belongs to the thiolase family
E5093_RS06210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5093_RS06215	COG3327	negative regulation of DNA-templated transcription, initiation
E5093_RS06225	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_RS06245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5093_RS06250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5093_RS06250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5093_RS06255	COG1254	Belongs to the acylphosphatase family
E5093_RS06290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5093_RS06295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5093_RS06305	COG2353	YceI-like domain
E5093_RS06310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5093_RS06310	COG0519	Catalyzes the synthesis of GMP from XMP
E5093_RS06340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5093_RS06345	COG0583	DNA-binding transcription factor activity
E5093_RS06355	COG2707	UPF0756 membrane protein
E5093_RS06380	COG0802	atpase or kinase
E5093_RS06385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5093_RS06395	COG1923	regulation of RNA biosynthetic process
E5093_RS06400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5093_RS06410	COG3178	'Phosphotransferase
E5093_RS06415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5093_RS06425	COG1192	Involved in chromosome partitioning
E5093_RS06430	COG1475	DNA binding
E5093_RS06435	COG0811	peptide transport
E5093_RS06445	COG1132	(ABC) transporter
E5093_RS06450	COG1663	tetraacyldisaccharide 4'-kinase activity
E5093_RS06470	COG0084	hydrolase, TatD family'
E5093_RS06505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5093_RS06535	COG0776	regulation of translation
E5093_RS06545	COG0284	orotidine-5'-phosphate decarboxylase activity
E5093_RS06550	COG2431	L-lysine efflux transmembrane transporter activity
E5093_RS06565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5093_RS06570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5093_RS06590	COG1253	flavin adenine dinucleotide binding
E5093_RS06620	COG0583	DNA-binding transcription factor activity
E5093_RS06635	COG3852	Histidine kinase
E5093_RS06650	COG0233	cytoplasmic translational termination
E5093_RS06655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5093_RS06660	COG0575	Belongs to the CDS family
E5093_RS06695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5093_RS06725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5093_RS06735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5093_RS06740	COG2207	Transcriptional regulator
E5093_RS06745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5093_RS06755	COG1960	acyl-CoA dehydrogenase activity
E5093_RS06760	COG1960	acyl-CoA dehydrogenase activity
E5093_RS06795	COG4890	Cyd operon protein YbgT
E5093_RS06800	COG1294	oxidase, subunit
E5093_RS06815	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5093_RS06825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5093_RS06845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5093_RS06850	COG0569	domain protein
E5093_RS06860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5093_RS06880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5093_RS06885	COG0542	response to heat
E5093_RS06920	COG0372	Belongs to the citrate synthase family
E5093_RS06930	COG1058	Belongs to the CinA family
E5093_RS06930	COG1546	Belongs to the CinA family
E5093_RS06965	COG2814	Major facilitator Superfamily
E5093_RS06980	COG0439	Biotin carboxylase
E5093_RS06985	COG0511	ligase activity, forming carbon-carbon bonds
E5093_RS07020	COG0596	Alpha beta hydrolase
E5093_RS07110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5093_RS07115	COG1012	belongs to the aldehyde dehydrogenase family
E5093_RS07125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E5093_RS07130	COG1012	belongs to the aldehyde dehydrogenase family
E5093_RS07135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5093_RS07140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_RS07145	COG2267	carboxylic ester hydrolase activity
E5093_RS07170	COG0730	response to heat
E5093_RS07175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_RS07180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5093_RS07195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5093_RS07205	COG0745	RESPONSE REGULATOR receiver
E5093_RS07225	COG1012	belongs to the aldehyde dehydrogenase family
E5093_RS07230	COG1309	transcriptional regulator
E5093_RS07235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5093_RS07265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_RS07295	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_RS07305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5093_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS07315	COG1846	Transcriptional regulator
E5093_RS07320	COG2814	Major facilitator Superfamily
E5093_RS07335	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_RS07340	COG3293	Transposase
E5093_RS07355	COG2226	methyltransferase
E5093_RS07355	COG1073	alpha beta
E5093_RS07360	COG1960	acyl-CoA dehydrogenase activity
E5093_RS07370	COG1024	Enoyl-CoA hydratase
E5093_RS07375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5093_RS07380	COG0235	Class ii aldolase
E5093_RS07390	COG0183	Belongs to the thiolase family
E5093_RS07395	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_RS07400	COG1024	Enoyl-CoA hydratase
E5093_RS07405	COG2814	Major facilitator Superfamily
E5093_RS07415	COG2814	Major facilitator Superfamily
E5093_RS07425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_RS07430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5093_RS07435	COG2814	Major facilitator Superfamily
E5093_RS07440	COG1960	acyl-CoA dehydrogenase activity
E5093_RS07445	COG1960	acyl-CoA dehydrogenase activity
E5093_RS07455	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5093_RS07455	COG0644	oxidoreductase
E5093_RS07460	COG0515	serine threonine protein kinase
E5093_RS07465	COG2116	formate transmembrane transporter activity
E5093_RS07470	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E5093_RS07480	COG2223	nitrite transmembrane transporter activity
E5093_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS07520	COG2814	Major facilitator Superfamily
E5093_RS07525	COG0583	DNA-binding transcription factor activity
E5093_RS07530	COG4948	Mandelate Racemase Muconate Lactonizing
E5093_RS07535	COG4829	muconolactone delta-isomerase
E5093_RS07545	COG4638	Rieske (2fe-2S)
E5093_RS07550	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5093_RS07555	COG0633	Ferredoxin
E5093_RS07555	COG0543	2 iron, 2 sulfur cluster binding
E5093_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS07565	COG3135	benzoate transporter
E5093_RS07570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5093_RS07575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_RS07580	COG0183	Belongs to the thiolase family
E5093_RS07585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_RS07605	COG0583	DNA-binding transcription factor activity
E5093_RS07610	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5093_RS07615	COG4149	molybdate abc transporter
E5093_RS07620	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5093_RS07625	COG0303	'Molybdopterin
E5093_RS07630	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5093_RS07630	COG0315	cyclic pyranopterin monophosphate synthase activity
E5093_RS07645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5093_RS07655	COG0243	molybdopterin cofactor binding
E5093_RS07660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_RS07665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_RS07670	COG2223	nitrite transmembrane transporter activity
E5093_RS07680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5093_RS07680	COG1116	anion transmembrane transporter activity
E5093_RS07685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5093_RS07690	COG2937	Belongs to the GPAT DAPAT family
E5093_RS07695	COG0640	Transcriptional regulator
E5093_RS07715	COG3122	Protein conserved in bacteria
E5093_RS07720	COG0668	transmembrane transport
E5093_RS07740	COG1132	(ABC) transporter
E5093_RS07760	COG2814	Major facilitator Superfamily
E5093_RS07770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5093_RS07780	COG1113	amino acid transport
E5093_RS07795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5093_RS07800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5093_RS07850	COG1525	nuclease
E5093_RS07860	COG1294	oxidase, subunit
E5093_RS07865	COG1271	oxidase subunit
E5093_RS07875	COG2814	Major facilitator Superfamily
E5093_RS07880	COG2207	Transcriptional regulator
E5093_RS07885	COG1960	acyl-CoA dehydrogenase activity
E5093_RS07905	COG1629	transport
E5093_RS07920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5093_RS07925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E5093_RS07945	COG0583	DNA-binding transcription factor activity
E5093_RS07955	COG1346	cytolysis
E5093_RS07965	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5093_RS07975	COG0693	protein deglycase activity
E5093_RS08020	COG0552	protein localization to endoplasmic reticulum
E5093_RS08025	COG0612	Peptidase, M16
E5093_RS08055	COG0517	IMP dehydrogenase activity
E5093_RS08055	COG0617	tRNA 3'-terminal CCA addition
E5093_RS08055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5093_RS08060	COG0133	tryptophan synthase activity
E5093_RS08070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5093_RS08090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5093_RS08145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5093_RS08175	COG0822	iron-sulfur transferase activity
E5093_RS08180	COG0316	Belongs to the HesB IscA family
E5093_RS08210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5093_RS08225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5093_RS08230	COG0702	epimerase
E5093_RS08235	COG0268	Binds directly to 16S ribosomal RNA
E5093_RS08255	COG1011	Hydrolase
E5093_RS08260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5093_RS08270	COG2137	regulation of response to DNA damage stimulus
E5093_RS08285	COG0772	Belongs to the SEDS family
E5093_RS08300	COG0148	phosphopyruvate hydratase activity
E5093_RS08330	COG1902	pentaerythritol trinitrate reductase activity
E5093_RS08330	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5093_RS08345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5093_RS08355	COG3293	Transposase
E5093_RS08360	COG1960	acyl-CoA dehydrogenase activity
E5093_RS08365	COG0583	DNA-binding transcription factor activity
E5093_RS08370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5093_RS08375	COG1027	Aspartate ammonia-lyase
E5093_RS08380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5093_RS08390	COG0506	proline dehydrogenase activity
E5093_RS08390	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5093_RS08390	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5093_RS08410	COG3698	Phosphodiester glycosidase
E5093_RS08450	COG0697	spore germination
E5093_RS08475	COG0424	maF-like protein
E5093_RS08480	COG2850	peptidyl-arginine hydroxylation
E5093_RS08485	COG4585	Histidine kinase
E5093_RS08495	COG0069	glutamate synthase activity
E5093_RS08515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5093_RS08520	COG1454	alcohol dehydrogenase
E5093_RS08525	COG0824	Thioesterase
E5093_RS08530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5093_RS08545	COG2030	dehydratase
E5093_RS08555	COG0183	Belongs to the thiolase family
E5093_RS08570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5093_RS08580	COG3135	benzoate transporter
E5093_RS08590	COG0589	response to stress
E5093_RS08595	COG0589	response to stress
E5093_RS08605	COG0308	aminopeptidase N
E5093_RS08635	COG0786	glutamate:sodium symporter activity
E5093_RS08675	COG0477	Major facilitator Superfamily
E5093_RS08690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5093_RS08700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5093_RS08710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5093_RS08715	COG1960	acyl-CoA dehydrogenase activity
E5093_RS08735	COG3781	membrane
E5093_RS08740	COG2890	protein-(glutamine-N5) methyltransferase activity
E5093_RS08745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5093_RS08760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5093_RS08785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5093_RS08790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5093_RS08795	COG1845	cytochrome c oxidase, subunit III
E5093_RS08800	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5093_RS08810	COG0360	Binds together with S18 to 16S ribosomal RNA
E5093_RS08815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5093_RS08830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5093_RS08845	COG1305	Transglutaminase-like
E5093_RS08855	COG2308	Evidence 4 Homologs of previously reported genes of
E5093_RS08895	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5093_RS08900	COG0138	bifunctional purine biosynthesis protein purh
E5093_RS08920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5093_RS08925	COG2011	ABC-type metal ion transport system permease component
E5093_RS08970	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5093_RS08980	COG4122	O-methyltransferase activity
E5093_RS09005	COG2274	protein secretion by the type I secretion system
E5093_RS09015	COG1137	ATPase activity
E5093_RS09020	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5093_RS09030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5093_RS09035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5093_RS09035	COG0517	IMP dehydrogenase activity
E5093_RS09060	COG1643	Atp-dependent helicase
E5093_RS09090	COG3634	alkyl hydroperoxide reductase activity
E5093_RS09100	COG2391	methyltransferase activity
E5093_RS09125	COG2070	2-Nitropropane dioxygenase
E5093_RS09140	COG1278	Cold shock
E5093_RS09205	COG1309	transcriptional regulator
E5093_RS09210	COG0596	Alpha beta hydrolase
E5093_RS09250	COG0352	thiamine-phosphate diphosphorylase activity
E5093_RS09285	COG0612	Peptidase, M16
E5093_RS09295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_RS09305	COG0739	heme binding
E5093_RS09320	COG1187	pseudouridine synthase activity
E5093_RS09335	COG1686	Belongs to the peptidase S11 family
E5093_RS09340	COG1252	NADH dehydrogenase
E5093_RS09345	COG1047	Peptidyl-prolyl cis-trans
E5093_RS09370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5093_RS09375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5093_RS09390	COG0693	protein deglycase activity
E5093_RS09395	COG1960	acyl-CoA dehydrogenase activity
E5093_RS09400	COG1301	dicarboxylic acid transport
E5093_RS09410	COG3139	Protein of unknown function (DUF1315)
E5093_RS09415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5093_RS09420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5093_RS09440	COG0642	Histidine kinase
E5093_RS09445	COG0745	RESPONSE REGULATOR receiver
E5093_RS09455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5093_RS09465	COG1720	tRNA m6t6A37 methyltransferase activity
E5093_RS09480	COG0789	Transcriptional regulator
E5093_RS09485	COG0431	NADPH-dependent FMN reductase
E5093_RS09490	COG0798	PFAM Bile acid sodium symporter
E5093_RS09500	COG0640	Transcriptional regulator
E5093_RS09515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5093_RS09520	COG3634	alkyl hydroperoxide reductase activity
E5093_RS09540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5093_RS09545	COG3385	transposase activity
E5093_RS09710	COG3728	DNA packaging
E5093_RS09710	COG5484	DNA packaging
E5093_RS09755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5093_RS09850	COG1131	(ABC) transporter
E5093_RS09855	COG0842	Transport permease protein
E5093_RS09870	COG2951	lytic endotransglycosylase activity
E5093_RS09895	COG0052	Belongs to the universal ribosomal protein uS2 family
E5093_RS09915	COG2175	clavaminate synthase activity
E5093_RS09925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5093_RS09955	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5093_RS09960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5093_RS09965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5093_RS09985	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E5093_RS10015	COG2871	sodium ion transport
E5093_RS10035	COG0582	viral genome integration into host DNA
E5093_RS10060	COG2223	nitrite transmembrane transporter activity
E5093_RS10130	COG0798	PFAM Bile acid sodium symporter
E5093_RS10140	COG0640	Transcriptional regulator
E5093_RS10165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5093_RS10235	COG0789	Transcriptional regulator
E5093_RS10280	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5093_RS10280	COG1902	pentaerythritol trinitrate reductase activity
E5093_RS10295	COG5001	Diguanylate cyclase
E5093_RS10295	COG4251	negative regulation of phosphorylation
E5093_RS10295	COG3706	GGDEF domain
E5093_RS10295	COG2203	Gaf domain
E5093_RS10300	COG0418	dihydroorotase activity
E5093_RS10305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5093_RS10330	COG0833	amino acid
E5093_RS10360	COG4172	Belongs to the ABC transporter superfamily
E5093_RS10365	COG4239	(ABC) transporter, permease
E5093_RS10370	COG4174	ABC transporter (Permease)
E5093_RS10375	COG4166	transmembrane transport
E5093_RS10380	COG0741	lytic transglycosylase activity
E5093_RS10380	COG1388	LysM domain
E5093_RS10395	COG2816	NAD+ diphosphatase activity
E5093_RS10430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5093_RS10435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5093_RS10440	COG0006	proline dipeptidase activity
E5093_RS10445	COG3079	Belongs to the UPF0149 family
E5093_RS10475	COG0277	FAD linked oxidase domain protein
E5093_RS10485	COG2186	Transcriptional regulator
E5093_RS10505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5093_RS10515	COG2234	aminopeptidase activity
E5093_RS10525	COG3384	dioxygenase
E5093_RS10535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5093_RS10540	COG2878	Part of a membrane complex involved in electron transport
E5093_RS10545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5093_RS10570	COG0768	penicillin binding
E5093_RS10575	COG0742	ribosomal rna small subunit methyltransferase
E5093_RS10590	COG0830	nickel cation binding
E5093_RS10605	COG0804	urea catabolic process
E5093_RS10625	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS10640	COG3015	lipoprotein NlpE involved in copper resistance
E5093_RS10660	COG1253	flavin adenine dinucleotide binding
E5093_RS10685	COG3118	belongs to the thioredoxin family
E5093_RS10715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5093_RS10720	COG1773	rubredoxin
E5093_RS10725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_RS10735	COG0583	DNA-binding transcription factor activity
E5093_RS10745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5093_RS10755	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5093_RS10760	COG4181	ATPase activity
E5093_RS10785	COG4771	TonB-dependent receptor
E5093_RS10810	COG0306	phosphate transporter
E5093_RS10835	COG2852	Protein conserved in bacteria
E5093_RS10840	COG2066	Belongs to the glutaminase family
E5093_RS10850	COG0477	Major facilitator Superfamily
E5093_RS10880	COG2203	Gaf domain
E5093_RS10880	COG2199	diguanylate cyclase activity
E5093_RS10890	COG4681	YaeQ
E5093_RS10895	COG0523	cobalamin synthesis protein
E5093_RS10915	COG0583	DNA-binding transcription factor activity
E5093_RS10920	COG2814	Major facilitator Superfamily
E5093_RS10930	COG1607	acyl-coa hydrolase
E5093_RS10940	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5093_RS10945	COG2059	Chromate
E5093_RS10950	COG1115	amino acid carrier protein
E5093_RS10955	COG0786	glutamate:sodium symporter activity
E5093_RS10970	COG2814	Major facilitator Superfamily
E5093_RS10975	COG1289	transmembrane transporter activity
E5093_RS10985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5093_RS11040	COG1376	ErfK ybiS ycfS ynhG family protein
E5093_RS11045	COG2832	Protein of unknown function (DUF454)
E5093_RS11055	COG5510	response to toxic substance
E5093_RS11070	COG0643	Histidine kinase
E5093_RS11070	COG2198	Histidine kinase
E5093_RS11070	COG0784	Response regulator, receiver
E5093_RS11075	COG0840	transmembrane signaling receptor activity
E5093_RS11110	COG0442	prolyl-tRNA aminoacylation
E5093_RS11145	COG2358	TRAP transporter, solute receptor (TAXI family
E5093_RS11160	COG0489	protein tyrosine kinase activity
E5093_RS11165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5093_RS11165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5093_RS11180	COG0004	ammonium transporteR
E5093_RS11195	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E5093_RS11210	COG2081	HI0933 family
E5093_RS11225	COG0668	transmembrane transport
E5093_RS11250	COG0583	DNA-binding transcription factor activity
E5093_RS11255	COG1278	Cold shock
E5093_RS11260	COG1278	Cold shock
E5093_RS11275	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5093_RS11280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5093_RS11285	COG0713	ATP synthesis coupled electron transport
E5093_RS11290	COG0839	Belongs to the complex I subunit 6 family
E5093_RS11295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5093_RS11300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5093_RS11310	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5093_RS11330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5093_RS11340	COG0142	geranyltranstransferase activity
E5093_RS11345	COG2828	Protein conserved in bacteria
E5093_RS11350	COG1113	amino acid transport
E5093_RS11370	COG0625	glutathione transferase activity
E5093_RS11410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5093_RS11420	COG1530	ribonuclease E activity
E5093_RS11425	COG0424	maF-like protein
E5093_RS11430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5093_RS11435	COG1792	Involved in formation and maintenance of cell shape
E5093_RS11440	COG1077	Cell shape determining protein MreB Mrl
E5093_RS11445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5093_RS11450	COG0154	amidase activity
E5093_RS11455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5093_RS11490	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E5093_RS11505	COG1215	transferase activity, transferring glycosyl groups
E5093_RS11510	COG1649	PFAM Uncharacterised BCR, COG1649
E5093_RS11510	COG0726	polysaccharide deacetylase
E5093_RS11540	COG3177	Filamentation induced by cAMP protein fic
E5093_RS11555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5093_RS11560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5093_RS11585	COG0640	Transcriptional regulator
E5093_RS11595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5093_RS11605	COG0745	RESPONSE REGULATOR receiver
E5093_RS11610	COG0642	Histidine kinase
E5093_RS11620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5093_RS11695	COG0582	viral genome integration into host DNA
E5093_RS11705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5093_RS11710	COG2050	protein possibly involved in aromatic compounds catabolism
E5093_RS11730	COG0420	3'-5' exonuclease activity
E5093_RS11760	COG0735	belongs to the Fur family
E5093_RS11765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5093_RS11770	COG2914	Belongs to the UPF0125 (RnfH) family
E5093_RS11785	COG0121	glutamine amidotransferase
E5093_RS11800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5093_RS11810	COG0210	DNA helicase
E5093_RS11815	COG2885	chlorophyll binding
E5093_RS11820	COG0204	Acyl-transferase
E5093_RS11830	COG0850	regulation of cytokinetic process
E5093_RS11835	COG2894	cell division
E5093_RS11850	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5093_RS11850	COG1674	ftsk spoiiie
E5093_RS11855	COG0492	ferredoxin-NADP+ reductase activity
E5093_RS11860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5093_RS11870	COG0456	acetyltransferase
E5093_RS11895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5093_RS11915	COG1113	amino acid transport
E5093_RS11920	COG0251	oxidation-reduction process
E5093_RS11945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5093_RS11945	COG0352	thiamine-phosphate diphosphorylase activity
E5093_RS11945	COG0351	phosphomethylpyrimidine kinase
E5093_RS11960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5093_RS11975	COG2132	Multicopper oxidase
E5093_RS11985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5093_RS12000	COG4269	membrane
E5093_RS12020	COG1968	undecaprenyl-diphosphatase activity
E5093_RS12025	COG1214	PFAM Peptidase M22, glycoprotease
E5093_RS12035	COG0494	nUDIX hydrolase
E5093_RS12085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5093_RS12090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5093_RS12150	COG2199	diguanylate cyclase activity
E5093_RS12155	COG2885	chlorophyll binding
E5093_RS12180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5093_RS12185	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5093_RS12200	COG0450	alkyl hydroperoxide reductase
E5093_RS12215	COG0285	dihydrofolate synthase activity
E5093_RS12220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5093_RS12265	COG4206	TonB-dependent receptor
E5093_RS12270	COG2096	Adenosyltransferase
E5093_RS12290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5093_RS12295	COG2315	Protein conserved in bacteria
E5093_RS12305	COG0745	RESPONSE REGULATOR receiver
E5093_RS12310	COG2205	protein histidine kinase activity
E5093_RS12320	COG1960	acyl-CoA dehydrogenase activity
E5093_RS12325	COG1960	acyl-CoA dehydrogenase activity
E5093_RS12330	COG3223	Belongs to the PsiE family
E5093_RS12365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5093_RS12395	COG0463	Glycosyl transferase, family 2
E5093_RS12415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5093_RS12420	COG5002	protein histidine kinase activity
E5093_RS12430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5093_RS12440	COG0732	type I restriction modification DNA specificity domain
E5093_RS12445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5093_RS12460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5093_RS12470	COG2026	Addiction module toxin, RelE StbE family
E5093_RS12480	COG0415	Belongs to the DNA photolyase family
E5093_RS12515	COG0582	viral genome integration into host DNA
E5093_RS12525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5093_RS12535	COG1704	LemA family
E5093_RS12540	COG3706	GGDEF domain
E5093_RS12540	COG4251	negative regulation of phosphorylation
E5093_RS12540	COG5001	Diguanylate cyclase
E5093_RS12540	COG2203	Gaf domain
E5093_RS12555	COG1862	Preprotein translocase
E5093_RS12575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5093_RS12590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5093_RS12595	COG2205	protein histidine kinase activity
E5093_RS12595	COG5002	protein histidine kinase activity
E5093_RS12595	COG0784	Response regulator, receiver
E5093_RS12600	COG1024	Enoyl-CoA hydratase
E5093_RS12610	COG3622	Belongs to the hyi family
E5093_RS12635	COG0697	spore germination
E5093_RS12640	COG2814	Major facilitator Superfamily
E5093_RS12680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5093_RS12690	COG0732	type I restriction modification DNA specificity domain
E5093_RS12700	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5093_RS12715	COG0174	glutamine synthetase
E5093_RS12730	COG0745	RESPONSE REGULATOR receiver
E5093_RS12735	COG2205	protein histidine kinase activity
E5093_RS12745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5093_RS12750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5093_RS12830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5093_RS12835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5093_RS12840	COG0084	hydrolase, TatD family'
E5093_RS12855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5093_RS12870	COG0793	Belongs to the peptidase S41A family
E5093_RS12900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5093_RS12905	COG0857	belongs to the CobB CobQ family
E5093_RS12905	COG0280	phosphate acetyltransferase
E5093_RS12930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5093_RS12930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5093_RS12945	COG0740	serine-type endopeptidase activity
E5093_RS12955	COG4771	TonB-dependent receptor
E5093_RS12960	COG4774	siderophore transport
E5093_RS12965	COG3128	pkhd-type hydroxylase
E5093_RS12975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5093_RS12980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_RS12985	COG2813	Specifically methylates the guanine in position
E5093_RS12985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_RS13045	COG3040	lipid binding
E5093_RS13110	COG3040	lipid binding
E5093_RS13140	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5093_RS13180	COG0557	exoribonuclease II activity
E5093_RS13190	COG0339	signal peptide processing
E5093_RS13195	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5093_RS13205	COG0697	spore germination
E5093_RS13210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5093_RS13235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5093_RS13240	COG1960	acyl-CoA dehydrogenase activity
E5093_RS13245	COG2072	flavoprotein involved in K transport
E5093_RS13255	COG0202	RNA polymerase activity
E5093_RS13260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5093_RS13295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5093_RS13305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5093_RS13310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5093_RS13345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5093_RS13375	COG0088	Forms part of the polypeptide exit tunnel
E5093_RS13400	COG0433	COG0433 Predicted ATPase
E5093_RS13410	COG1959	2 iron, 2 sulfur cluster binding
E5093_RS13430	COG1301	dicarboxylic acid transport
E5093_RS13435	COG1946	Acyl-CoA thioesterase
E5093_RS13440	COG2937	Belongs to the GPAT DAPAT family
E5093_RS13450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5093_RS13455	COG1040	competence protein
E5093_RS13470	COG0598	Magnesium transport protein CorA
E5093_RS13480	COG2854	intermembrane phospholipid transfer
E5093_RS13485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5093_RS13490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5093_RS13495	COG1127	ABC transporter
E5093_RS13520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5093_RS13540	COG1960	acyl-CoA dehydrogenase activity
E5093_RS13545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5093_RS13555	COG0534	Mate efflux family protein
E5093_RS13560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5093_RS13565	COG0254	rRNA binding
E5093_RS13570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5093_RS13590	COG2226	methyltransferase
E5093_RS13605	COG1192	Involved in chromosome partitioning
E5093_RS13610	COG0628	permease
E5093_RS13620	COG2814	Major facilitator Superfamily
E5093_RS13635	COG0277	FAD linked oxidase domain protein
E5093_RS13640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5093_RS13665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5093_RS13670	COG5380	lipid catabolic process
E5093_RS13690	COG0335	large ribosomal subunit rRNA binding
E5093_RS13700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5093_RS13705	COG0228	four-way junction DNA binding
E5093_RS13740	COG4969	Belongs to the N-Me-Phe pilin family
E5093_RS13750	COG0194	GDP metabolic process
E5093_RS13755	COG1758	RNA polymerase activity
E5093_RS13760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5093_RS13780	COG3307	-O-antigen
E5093_RS13795	COG4969	Belongs to the N-Me-Phe pilin family
E5093_RS13805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E5093_RS13810	COG1704	LemA family
E5093_RS13820	COG0493	'glutamate synthase
E5093_RS13825	COG0067	glutamate synthase
E5093_RS13825	COG0069	glutamate synthase activity
E5093_RS13825	COG0070	glutamate synthase
E5093_RS13885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5093_RS13890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5093_RS13905	COG0275	rRNA processing
E5093_RS13910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5093_RS13920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5093_RS13940	COG0488	(ABC) transporter
E5093_RS13950	COG4221	oxidoreductase activity
E5093_RS13975	COG0745	RESPONSE REGULATOR receiver
E5093_RS13980	COG2205	protein histidine kinase activity
E5093_RS13985	COG0427	acetyl-CoA hydrolase
E5093_RS14015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5093_RS14035	COG0697	spore germination
E5093_RS14050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5093_RS14090	COG3158	transport of potassium into the cell
E5093_RS14115	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E5093_RS14145	COG3077	Addiction module antitoxin, RelB DinJ family
E5093_RS14160	COG2132	Multicopper oxidase
E5093_RS14170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5093_RS14215	COG2132	Multicopper oxidase
E5093_RS14230	COG2205	protein histidine kinase activity
E5093_RS14235	COG3174	membrane
E5093_RS14240	COG2217	Heavy metal translocating P-type atpase
E5093_RS14340	COG0629	single-stranded DNA binding
E5093_RS14345	COG2814	Major facilitator Superfamily
E5093_RS14355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5093_RS14360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5093_RS14365	COG3706	GGDEF domain
E5093_RS14375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5093_RS14395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5093_RS14400	COG3162	membrane
E5093_RS14405	COG0784	Response regulator, receiver
E5093_RS14405	COG2205	protein histidine kinase activity
E5093_RS14420	COG0431	NADPH-dependent FMN reductase
E5093_RS14435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5093_RS14440	COG0668	transmembrane transport
E5093_RS14445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5093_RS14450	COG1519	Transferase
E5093_RS14455	COG1902	pentaerythritol trinitrate reductase activity
E5093_RS14460	COG0640	Transcriptional regulator
E5093_RS14465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E5093_RS14480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5093_RS14505	COG0426	domain, Protein
E5093_RS14505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_RS14510	COG2119	membrane
E5093_RS14540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5093_RS14550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5093_RS14560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5093_RS14565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5093_RS14570	COG0189	ligase activity
E5093_RS14575	COG0386	Belongs to the glutathione peroxidase family
E5093_RS14580	COG1846	Transcriptional regulator
E5093_RS14595	COG0708	Exodeoxyribonuclease III
E5093_RS14600	COG1393	Belongs to the ArsC family
E5093_RS14615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5093_RS14620	COG3706	GGDEF domain
E5093_RS14625	COG0625	glutathione transferase activity
E5093_RS14665	COG1247	-acetyltransferase
E5093_RS14670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5093_RS14680	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E5093_RS14690	COG0471	metal ion transport
E5093_RS14730	COG3150	esterase
E5093_RS14740	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5093_RS14745	COG2918	glutathione biosynthetic process
E5093_RS14760	COG2733	membrane
E5093_RS14765	COG0436	Aminotransferase
E5093_RS14770	COG0534	Mate efflux family protein
E5093_RS14815	COG0753	catalase activity
E5093_RS14835	COG0560	Phosphoserine phosphatase
E5093_RS14835	COG3830	Belongs to the UPF0237 family
E5093_RS14850	COG0385	Bile acid
E5093_RS14855	COG1335	isochorismatase
E5093_RS14860	COG2814	Major facilitator Superfamily
E5093_RS14865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5093_RS14875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5093_RS14880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5093_RS14885	COG2983	Belongs to the UPF0260 family
E5093_RS14890	COG5487	UPF0391 membrane protein
E5093_RS14905	COG1194	a g-specific adenine glycosylase
E5093_RS14910	COG0739	heme binding
E5093_RS14920	COG2818	Glycosylase
E5093_RS14925	COG1064	alcohol dehydrogenase
E5093_RS14945	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5093_RS14955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5093_RS14960	COG1309	transcriptional regulator
E5093_RS14970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5093_RS14975	COG0546	phosphoglycolate phosphatase activity
E5093_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_RS15005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5093_RS15005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5093_RS15010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5093_RS15015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5093_RS15020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5093_RS15025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5093_RS15030	COG1116	anion transmembrane transporter activity
E5093_RS15035	COG1309	transcriptional regulator
E5093_RS15045	COG0196	riboflavin kinase activity
E5093_RS15050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5093_RS15055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5093_RS15060	COG1047	Peptidyl-prolyl cis-trans
E5093_RS15070	COG2133	pyrroloquinoline quinone binding
E5093_RS15075	COG2814	Major facilitator Superfamily
E5093_RS15105	COG0737	Belongs to the 5'-nucleotidase family
E5093_RS15115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5093_RS15120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5093_RS15145	COG0488	(ABC) transporter
E5093_RS15150	COG1063	alcohol dehydrogenase
E5093_RS15155	COG0187	DNA topoisomerase II activity
E5093_RS15165	COG0592	DNA-directed DNA polymerase activity