locus-tag	class	description
H0S57_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S57_RS00010	COG0592	DNA-directed DNA polymerase activity
H0S57_RS00020	COG0187	DNA topoisomerase II activity
H0S57_RS00035	COG0488	(ABC) transporter
H0S57_RS00100	COG0657	acetylesterase activity
H0S57_RS00110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S57_RS00140	COG2133	pyrroloquinoline quinone binding
H0S57_RS00155	COG1047	Peptidyl-prolyl cis-trans
H0S57_RS00160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0S57_RS00165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S57_RS00170	COG0196	riboflavin kinase activity
H0S57_RS00185	COG1309	transcriptional regulator
H0S57_RS00190	COG1116	anion transmembrane transporter activity
H0S57_RS00195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S57_RS00200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S57_RS00205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_RS00210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_RS00215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S57_RS00215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0S57_RS00240	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS00245	COG0546	phosphoglycolate phosphatase activity
H0S57_RS00250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0S57_RS00255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S57_RS00260	COG3307	-O-antigen
H0S57_RS00270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S57_RS00280	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0S57_RS00285	COG0728	peptidoglycan biosynthetic process
H0S57_RS00315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S57_RS00340	COG0438	transferase activity, transferring glycosyl groups
H0S57_RS00345	COG0438	transferase activity, transferring glycosyl groups
H0S57_RS00350	COG0438	transferase activity, transferring glycosyl groups
H0S57_RS00355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0S57_RS00360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S57_RS00370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0S57_RS00385	COG1091	dTDP-4-dehydrorhamnose reductase activity
H0S57_RS00410	COG1442	glycosyl transferase family 8
H0S57_RS00410	COG1216	Glycosyl transferase, family 2
H0S57_RS00415	COG0463	Glycosyl transferase, family 2
H0S57_RS00420	COG0438	transferase activity, transferring glycosyl groups
H0S57_RS00420	COG0297	glycogen (starch) synthase activity
H0S57_RS00430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S57_RS00435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S57_RS00450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S57_RS00460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S57_RS00475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S57_RS00485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S57_RS00490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S57_RS00500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0S57_RS00515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0S57_RS00520	COG0583	DNA-binding transcription factor activity
H0S57_RS00540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S57_RS00565	COG2986	histidine ammonia-lyase
H0S57_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS00610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0S57_RS00680	COG1538	Outer membrane efflux protein
H0S57_RS00715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0S57_RS00735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_RS00765	COG0784	Response regulator, receiver
H0S57_RS00765	COG2205	protein histidine kinase activity
H0S57_RS00780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_RS00865	COG0271	Belongs to the BolA IbaG family
H0S57_RS00875	COG1192	Involved in chromosome partitioning
H0S57_RS00890	COG0586	Pfam SNARE associated Golgi protein
H0S57_RS00905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S57_RS00905	COG0519	Catalyzes the synthesis of GMP from XMP
H0S57_RS00910	COG1715	Restriction endonuclease
H0S57_RS00955	COG0281	malic enzyme
H0S57_RS00980	COG2837	iron assimilation
H0S57_RS00990	COG1683	Conserved Protein
H0S57_RS00995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S57_RS01000	COG1121	(ABC) transporter
H0S57_RS01050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0S57_RS01095	COG0386	Belongs to the glutathione peroxidase family
H0S57_RS01105	COG0697	spore germination
H0S57_RS01115	COG0758	DNA mediated transformation
H0S57_RS01190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S57_RS01200	COG2814	Major facilitator Superfamily
H0S57_RS01220	COG1253	flavin adenine dinucleotide binding
H0S57_RS01225	COG3012	SEC-C Motif Domain Protein
H0S57_RS01230	COG2860	membrane
H0S57_RS01235	COG0477	Major facilitator Superfamily
H0S57_RS01245	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_RS01260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S57_RS01280	COG0606	chelatase, subunit chli
H0S57_RS01290	COG0347	Belongs to the P(II) protein family
H0S57_RS01295	COG0004	ammonium transporteR
H0S57_RS01305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S57_RS01305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S57_RS01320	COG0586	Pfam SNARE associated Golgi protein
H0S57_RS01340	COG0795	lipopolysaccharide-transporting ATPase activity
H0S57_RS01345	COG0795	lipopolysaccharide-transporting ATPase activity
H0S57_RS01350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S57_RS01355	COG0793	Belongs to the peptidase S41A family
H0S57_RS01370	COG2197	response regulator
H0S57_RS01375	COG1686	Belongs to the peptidase S11 family
H0S57_RS01380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S57_RS01390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S57_RS01395	COG4974	Belongs to the 'phage' integrase family
H0S57_RS01415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0S57_RS01420	COG0772	Belongs to the SEDS family
H0S57_RS01425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S57_RS01430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S57_RS01435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S57_RS01445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H0S57_RS01475	COG3275	phosphorelay sensor kinase activity
H0S57_RS01485	COG0181	hydroxymethylbilane synthase activity
H0S57_RS01550	COG0546	phosphoglycolate phosphatase activity
H0S57_RS01580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S57_RS01600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0S57_RS01605	COG0081	regulation of translation
H0S57_RS01610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0S57_RS01615	COG0222	ribosome binding
H0S57_RS01620	COG0085	RNA polymerase activity
H0S57_RS01625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0S57_RS01655	COG2056	Na+-H+ antiporter family
H0S57_RS01660	COG3047	cAMP biosynthetic process
H0S57_RS01670	COG0326	Molecular chaperone. Has ATPase activity
H0S57_RS01700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S57_RS01770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S57_RS01775	COG1132	(ABC) transporter
H0S57_RS01790	COG1289	transmembrane transporter activity
H0S57_RS01805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S57_RS01810	COG1678	Uncharacterized ACR, COG1678
H0S57_RS01815	COG0497	DNA recombination
H0S57_RS01825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S57_RS01835	COG0237	dephospho-CoA kinase activity
H0S57_RS01895	COG0195	Participates in both transcription termination and antitermination
H0S57_RS01905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0S57_RS01910	COG1320	monovalent cation:proton antiporter activity
H0S57_RS01915	COG2212	antiporter activity
H0S57_RS01920	COG1863	multisubunit Na H antiporter MnhE subunit
H0S57_RS01925	COG0651	ATP synthesis coupled electron transport
H0S57_RS01930	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S57_RS01935	COG2111	Na H antiporter
H0S57_RS01935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S57_RS01940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0S57_RS01950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S57_RS01970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S57_RS02000	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S57_RS02005	COG1074	ATP-dependent DNA helicase activity
H0S57_RS02010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S57_RS02015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S57_RS02025	COG1185	polyribonucleotide nucleotidyltransferase activity
H0S57_RS02030	COG0598	Magnesium transport protein CorA
H0S57_RS02035	COG2841	Protein conserved in bacteria
H0S57_RS02055	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0S57_RS02065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S57_RS02085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S57_RS02090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0S57_RS02095	COG4535	Mg2 and Co2 transporter CorC
H0S57_RS02100	COG0425	Belongs to the sulfur carrier protein TusA family
H0S57_RS02120	COG0644	oxidoreductase
H0S57_RS02120	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S57_RS02130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S57_RS02140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0S57_RS02145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S57_RS02150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S57_RS02160	COG0493	'glutamate synthase
H0S57_RS02160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S57_RS02190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0S57_RS02220	COG0751	glycine-tRNA ligase activity
H0S57_RS02240	COG1983	PspC domain protein
H0S57_RS02265	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_RS02270	COG1530	ribonuclease E activity
H0S57_RS02280	COG0546	phosphoglycolate phosphatase activity
H0S57_RS02290	COG0583	DNA-binding transcription factor activity
H0S57_RS02320	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS02335	COG1280	lysine exporter protein (LysE YggA)
H0S57_RS02370	COG0583	DNA-binding transcription factor activity
H0S57_RS02380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0S57_RS02395	COG0473	3-isopropylmalate dehydrogenase activity
H0S57_RS02450	COG1560	Kdo2-lipid A biosynthetic process
H0S57_RS02455	COG0488	(ABC) transporter
H0S57_RS02460	COG2900	Belongs to the SlyX family
H0S57_RS02500	COG1929	Belongs to the glycerate kinase type-1 family
H0S57_RS02505	COG0210	DNA helicase
H0S57_RS02530	COG4651	solute:proton antiporter activity
H0S57_RS02530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S57_RS02555	COG0788	formyltetrahydrofolate deformylase activity
H0S57_RS02665	COG2813	Specifically methylates the guanine in position
H0S57_RS02665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S57_RS02675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S57_RS02690	COG4774	siderophore transport
H0S57_RS02695	COG4771	TonB-dependent receptor
H0S57_RS02705	COG0740	serine-type endopeptidase activity
H0S57_RS02725	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S57_RS02725	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S57_RS02730	COG1917	Cupin 2, conserved barrel domain protein
H0S57_RS02730	COG2207	Transcriptional regulator
H0S57_RS02735	COG0697	spore germination
H0S57_RS02740	COG2318	DinB family
H0S57_RS02750	COG0857	belongs to the CobB CobQ family
H0S57_RS02750	COG0280	phosphate acetyltransferase
H0S57_RS02755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S57_RS02760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H0S57_RS02780	COG0793	Belongs to the peptidase S41A family
H0S57_RS02790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S57_RS02805	COG0084	hydrolase, TatD family'
H0S57_RS02815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S57_RS02835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S57_RS02910	COG3646	Phage regulatory protein
H0S57_RS03060	COG4695	Portal protein
H0S57_RS03080	COG2814	Major facilitator Superfamily
H0S57_RS03105	COG0004	ammonium transporteR
H0S57_RS03120	COG3622	Belongs to the hyi family
H0S57_RS03125	COG2084	Dehydrogenase
H0S57_RS03130	COG1024	Enoyl-CoA hydratase
H0S57_RS03135	COG0784	Response regulator, receiver
H0S57_RS03135	COG5002	protein histidine kinase activity
H0S57_RS03135	COG2205	protein histidine kinase activity
H0S57_RS03140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S57_RS03155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S57_RS03160	COG0300	oxidoreductase activity
H0S57_RS03165	COG3956	TIGRFAM MazG family protein
H0S57_RS03170	COG1555	photosystem II stabilization
H0S57_RS03175	COG0617	tRNA 3'-terminal CCA addition
H0S57_RS03180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S57_RS03190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0S57_RS03195	COG1660	Displays ATPase and GTPase activities
H0S57_RS03205	COG3028	Belongs to the UPF0307 family
H0S57_RS03210	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_RS03230	COG0625	glutathione transferase activity
H0S57_RS03240	COG1238	metal cluster binding
H0S57_RS03290	COG0072	phenylalanine-tRNA ligase activity
H0S57_RS03315	COG0248	Ppx GppA phosphatase
H0S57_RS03325	COG0037	tRNA processing
H0S57_RS03340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S57_RS03340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S57_RS03370	COG1764	response to oxidative stress
H0S57_RS03375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_RS03385	COG2208	phosphoserine phosphatase activity
H0S57_RS03390	COG2853	Lipoprotein
H0S57_RS03420	COG2814	Major facilitator Superfamily
H0S57_RS03460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S57_RS03470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S57_RS03495	COG0494	nUDIX hydrolase
H0S57_RS03500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S57_RS03505	COG1214	PFAM Peptidase M22, glycoprotease
H0S57_RS03510	COG1968	undecaprenyl-diphosphatase activity
H0S57_RS03525	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H0S57_RS03545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S57_RS03555	COG2132	Multicopper oxidase
H0S57_RS03580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S57_RS03590	COG0351	phosphomethylpyrimidine kinase
H0S57_RS03590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S57_RS03590	COG0352	thiamine-phosphate diphosphorylase activity
H0S57_RS03620	COG0251	oxidation-reduction process
H0S57_RS03625	COG1113	amino acid transport
H0S57_RS03635	COG1981	membrane
H0S57_RS03650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S57_RS03665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S57_RS03675	COG0456	acetyltransferase
H0S57_RS03685	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S57_RS03690	COG0492	ferredoxin-NADP+ reductase activity
H0S57_RS03695	COG1674	ftsk spoiiie
H0S57_RS03695	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0S57_RS03710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H0S57_RS03715	COG2894	cell division
H0S57_RS03720	COG0850	regulation of cytokinetic process
H0S57_RS03730	COG0204	Acyl-transferase
H0S57_RS03735	COG2885	chlorophyll binding
H0S57_RS03740	COG0210	DNA helicase
H0S57_RS03745	COG0756	dUTP diphosphatase activity
H0S57_RS03760	COG0121	glutamine amidotransferase
H0S57_RS03775	COG2914	Belongs to the UPF0125 (RnfH) family
H0S57_RS03780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S57_RS03785	COG0735	belongs to the Fur family
H0S57_RS03815	COG0420	3'-5' exonuclease activity
H0S57_RS03820	COG2203	Gaf domain
H0S57_RS03820	COG3706	GGDEF domain
H0S57_RS03820	COG5001	Diguanylate cyclase
H0S57_RS03820	COG4251	negative regulation of phosphorylation
H0S57_RS03830	COG1090	epimerase
H0S57_RS03845	COG2050	protein possibly involved in aromatic compounds catabolism
H0S57_RS03850	COG1566	PFAM secretion protein HlyD family protein
H0S57_RS03855	COG2814	Major facilitator Superfamily
H0S57_RS03860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S57_RS03870	COG0582	viral genome integration into host DNA
H0S57_RS04025	COG2815	serine threonine protein kinase
H0S57_RS04025	COG0515	serine threonine protein kinase
H0S57_RS04035	COG0514	ATP-dependent DNA helicase (RecQ)
H0S57_RS04040	COG0582	viral genome integration into host DNA
H0S57_RS04090	COG2184	nucleotidyltransferase activity
H0S57_RS04215	COG3177	Filamentation induced by cAMP protein fic
H0S57_RS04245	COG4221	oxidoreductase activity
H0S57_RS04250	COG0583	DNA-binding transcription factor activity
H0S57_RS04255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S57_RS04260	COG0604	alcohol dehydrogenase
H0S57_RS04260	COG3321	synthase
H0S57_RS04275	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H0S57_RS04290	COG4772	TonB-dependent receptor
H0S57_RS04300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S57_RS04310	COG0583	DNA-binding transcription factor activity
H0S57_RS04315	COG2610	gluconate transmembrane transporter activity
H0S57_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS04335	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0S57_RS04370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S57_RS04380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S57_RS04385	COG1077	Cell shape determining protein MreB Mrl
H0S57_RS04390	COG1792	Involved in formation and maintenance of cell shape
H0S57_RS04395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0S57_RS04400	COG0424	maF-like protein
H0S57_RS04415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S57_RS04470	COG0640	Transcriptional regulator
H0S57_RS04480	COG0798	PFAM Bile acid sodium symporter
H0S57_RS04485	COG0431	NADPH-dependent FMN reductase
H0S57_RS04500	COG0625	glutathione transferase activity
H0S57_RS04520	COG1113	amino acid transport
H0S57_RS04535	COG1113	amino acid transport
H0S57_RS04540	COG2828	Protein conserved in bacteria
H0S57_RS04545	COG0142	geranyltranstransferase activity
H0S57_RS04560	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S57_RS04585	COG0745	RESPONSE REGULATOR receiver
H0S57_RS04590	COG0642	Histidine kinase
H0S57_RS04605	COG0004	ammonium transporteR
H0S57_RS04615	COG1126	abc transporter atp-binding protein
H0S57_RS04620	COG0765	amino acid transport
H0S57_RS04625	COG0765	amino acid transport
H0S57_RS04645	COG0668	transmembrane transport
H0S57_RS04660	COG2081	HI0933 family
H0S57_RS04665	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S57_RS04700	COG4716	Myosin-crossreactive antigen
H0S57_RS04725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S57_RS04745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S57_RS04745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S57_RS04770	COG0489	protein tyrosine kinase activity
H0S57_RS04785	COG2358	TRAP transporter, solute receptor (TAXI family
H0S57_RS04830	COG1566	PFAM secretion protein HlyD family protein
H0S57_RS04855	COG0840	transmembrane signaling receptor activity
H0S57_RS04860	COG2198	Histidine kinase
H0S57_RS04860	COG0643	Histidine kinase
H0S57_RS04860	COG0784	Response regulator, receiver
H0S57_RS04870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0S57_RS04885	COG2832	Protein of unknown function (DUF454)
H0S57_RS04955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S57_RS04965	COG1289	transmembrane transporter activity
H0S57_RS04985	COG0786	glutamate:sodium symporter activity
H0S57_RS04990	COG1115	amino acid carrier protein
H0S57_RS05000	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S57_RS05005	COG1607	acyl-coa hydrolase
H0S57_RS05015	COG0523	cobalamin synthesis protein
H0S57_RS05020	COG4681	YaeQ
H0S57_RS05030	COG2203	Gaf domain
H0S57_RS05030	COG2199	diguanylate cyclase activity
H0S57_RS05075	COG0477	Major facilitator Superfamily
H0S57_RS05080	COG0242	peptide deformylase activity
H0S57_RS05085	COG2207	Transcriptional regulator
H0S57_RS05090	COG2223	nitrite transmembrane transporter activity
H0S57_RS05110	COG0515	serine threonine protein kinase
H0S57_RS05110	COG2815	serine threonine protein kinase
H0S57_RS05120	COG0306	phosphate transporter
H0S57_RS05170	COG4181	ATPase activity
H0S57_RS05175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S57_RS05195	COG0583	DNA-binding transcription factor activity
H0S57_RS05205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_RS05210	COG1773	rubredoxin
H0S57_RS05215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0S57_RS05245	COG0210	DNA helicase
H0S57_RS05255	COG1695	Transcriptional regulator
H0S57_RS05270	COG4221	oxidoreductase activity
H0S57_RS05270	COG0604	alcohol dehydrogenase
H0S57_RS05270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S57_RS05270	COG3321	synthase
H0S57_RS05295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0S57_RS05310	COG0477	Major facilitator Superfamily
H0S57_RS05325	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H0S57_RS05330	COG1597	lipid kinase activity
H0S57_RS05350	COG0641	radical SAM
H0S57_RS05355	COG3119	arylsulfatase activity
H0S57_RS05380	COG0742	ribosomal rna small subunit methyltransferase
H0S57_RS05385	COG0768	penicillin binding
H0S57_RS05410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S57_RS05415	COG2878	Part of a membrane complex involved in electron transport
H0S57_RS05420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S57_RS05430	COG3384	dioxygenase
H0S57_RS05440	COG2234	aminopeptidase activity
H0S57_RS05455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S57_RS05465	COG2217	Heavy metal translocating P-type atpase
H0S57_RS05475	COG1914	H( )-stimulated, divalent metal cation uptake system
H0S57_RS05495	COG4770	biotin carboxylase activity
H0S57_RS05520	COG0006	proline dipeptidase activity
H0S57_RS05535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S57_RS05540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S57_RS05560	COG2915	High frequency lysogenization protein hflD homolog
H0S57_RS05580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S57_RS05585	COG1686	Belongs to the peptidase S11 family
H0S57_RS05600	COG0789	Transcriptional regulator
H0S57_RS05615	COG0753	catalase activity
H0S57_RS05770	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H0S57_RS05980	COG0582	viral genome integration into host DNA
H0S57_RS05995	COG0583	DNA-binding transcription factor activity
H0S57_RS06015	COG0657	acetylesterase activity
H0S57_RS06020	COG2816	NAD+ diphosphatase activity
H0S57_RS06030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S57_RS06035	COG1388	LysM domain
H0S57_RS06035	COG0741	lytic transglycosylase activity
H0S57_RS06040	COG4166	transmembrane transport
H0S57_RS06045	COG4174	ABC transporter (Permease)
H0S57_RS06050	COG4239	(ABC) transporter, permease
H0S57_RS06055	COG4172	Belongs to the ABC transporter superfamily
H0S57_RS06070	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H0S57_RS06095	COG0833	amino acid
H0S57_RS06125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S57_RS06130	COG0418	dihydroorotase activity
H0S57_RS06135	COG2203	Gaf domain
H0S57_RS06135	COG3706	GGDEF domain
H0S57_RS06135	COG4251	negative regulation of phosphorylation
H0S57_RS06135	COG5001	Diguanylate cyclase
H0S57_RS06150	COG2186	Transcriptional regulator
H0S57_RS06160	COG0277	FAD linked oxidase domain protein
H0S57_RS06165	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S57_RS06165	COG1902	pentaerythritol trinitrate reductase activity
H0S57_RS06195	COG0280	phosphate acetyltransferase
H0S57_RS06195	COG0281	malic enzyme
H0S57_RS06200	COG5001	Diguanylate cyclase
H0S57_RS06200	COG1716	ATPase activity
H0S57_RS06205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S57_RS06210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0S57_RS06215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S57_RS06255	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS06260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S57_RS06265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S57_RS06280	COG1671	Belongs to the UPF0178 family
H0S57_RS06295	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0S57_RS06300	COG1136	(ABC) transporter
H0S57_RS06305	COG2333	competence protein COMEC
H0S57_RS06305	COG0658	competence protein
H0S57_RS06325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S57_RS06330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0S57_RS06335	COG0628	permease
H0S57_RS06340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S57_RS06370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S57_RS06390	COG0823	Involved in the tonB-independent uptake of proteins
H0S57_RS06410	COG0824	Thioesterase
H0S57_RS06425	COG2255	four-way junction helicase activity
H0S57_RS06440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S57_RS06440	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S57_RS06455	COG3328	transposase activity
H0S57_RS06460	COG3323	Protein of unknown function (DUF1653)
H0S57_RS06460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S57_RS06480	COG1024	Enoyl-CoA hydratase
H0S57_RS06485	COG1056	cytidyltransferase-related domain
H0S57_RS06485	COG1051	belongs to the nudix hydrolase family
H0S57_RS06490	COG2353	YceI-like domain
H0S57_RS06495	COG0583	DNA-binding transcription factor activity
H0S57_RS06505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S57_RS06520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S57_RS06525	COG0602	queuosine metabolic process
H0S57_RS06545	COG0583	DNA-binding transcription factor activity
H0S57_RS06550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S57_RS06555	COG4208	sulfate ABC transporter
H0S57_RS06570	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S57_RS06580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S57_RS06600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S57_RS06615	COG0681	Belongs to the peptidase S26 family
H0S57_RS06630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S57_RS06640	COG1381	Involved in DNA repair and RecF pathway recombination
H0S57_RS06645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S57_RS06680	COG0436	Aminotransferase
H0S57_RS06690	COG2199	diguanylate cyclase activity
H0S57_RS06705	COG0556	nucleotide-excision repair
H0S57_RS06735	COG0702	epimerase
H0S57_RS06740	COG1733	regulation of RNA biosynthetic process
H0S57_RS06750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0S57_RS06755	COG0671	phosphoesterase, PA-phosphatase related
H0S57_RS06770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S57_RS06775	COG0076	glutamate decarboxylase activity
H0S57_RS06780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S57_RS06785	COG0573	inorganic phosphate transmembrane transporter activity
H0S57_RS06795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S57_RS06800	COG0616	signal peptide processing
H0S57_RS06805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S57_RS06810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S57_RS06815	COG1067	ATP-dependent peptidase activity
H0S57_RS06835	COG0254	rRNA binding
H0S57_RS06855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0S57_RS06860	COG1966	Carbon starvation protein
H0S57_RS06865	COG2879	small protein
H0S57_RS06885	COG0714	Associated with various cellular activities
H0S57_RS06920	COG1538	Outer membrane efflux protein
H0S57_RS06955	COG1131	(ABC) transporter
H0S57_RS06960	COG0842	Transport permease protein
H0S57_RS06965	COG0842	Transport permease protein
H0S57_RS06990	COG1309	transcriptional regulator
H0S57_RS07060	COG1733	regulation of RNA biosynthetic process
H0S57_RS07065	COG0604	alcohol dehydrogenase
H0S57_RS07080	COG1278	Cold shock
H0S57_RS07100	COG3038	cytochrome b561
H0S57_RS07110	COG2070	2-Nitropropane dioxygenase
H0S57_RS07135	COG3634	alkyl hydroperoxide reductase activity
H0S57_RS07155	COG0436	Aminotransferase
H0S57_RS07160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_RS07165	COG0386	Belongs to the glutathione peroxidase family
H0S57_RS07185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H0S57_RS07200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S57_RS07225	COG0012	GTP binding
H0S57_RS07235	COG2011	ABC-type metal ion transport system permease component
H0S57_RS07240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S57_RS07245	COG1464	Belongs to the NlpA lipoprotein family
H0S57_RS07250	COG1464	Belongs to the NlpA lipoprotein family
H0S57_RS07295	COG3293	Transposase
H0S57_RS07340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_RS07345	COG0183	Belongs to the thiolase family
H0S57_RS07365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_RS07370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S57_RS07375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_RS07395	COG1484	DNA-dependent DNA replication
H0S57_RS07495	COG2009	succinate dehydrogenase
H0S57_RS07505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S57_RS07515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H0S57_RS07550	COG0625	glutathione transferase activity
H0S57_RS07555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_RS07610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S57_RS07655	COG0582	viral genome integration into host DNA
H0S57_RS07695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S57_RS07700	COG0730	response to heat
H0S57_RS07720	COG4773	Receptor
H0S57_RS07725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S57_RS07730	COG1944	ATP diphosphatase activity
H0S57_RS07735	COG2207	Transcriptional regulator
H0S57_RS07740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S57_RS07745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S57_RS07775	COG2223	nitrite transmembrane transporter activity
H0S57_RS07790	COG1346	cytolysis
H0S57_RS07795	COG1380	Effector of murein hydrolase LrgA
H0S57_RS07820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S57_RS08080	COG4387	Mu-like prophage protein GP36
H0S57_RS08170	COG3772	lysozyme
H0S57_RS08185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S57_RS08255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S57_RS08260	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S57_RS08275	COG3300	MHYT domain
H0S57_RS08275	COG5001	Diguanylate cyclase
H0S57_RS08280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S57_RS08290	COG2814	Major facilitator Superfamily
H0S57_RS08305	COG1132	(ABC) transporter
H0S57_RS08315	COG0668	transmembrane transport
H0S57_RS08320	COG3122	Protein conserved in bacteria
H0S57_RS08340	COG0640	Transcriptional regulator
H0S57_RS08345	COG0596	Alpha beta hydrolase
H0S57_RS08350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S57_RS08355	COG1335	isochorismatase
H0S57_RS08360	COG0251	oxidation-reduction process
H0S57_RS08365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_RS08370	COG2233	PERMEase
H0S57_RS08380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S57_RS08390	COG0183	Belongs to the thiolase family
H0S57_RS08395	COG0583	DNA-binding transcription factor activity
H0S57_RS08410	COG0439	Biotin carboxylase
H0S57_RS08425	COG0511	ligase activity, forming carbon-carbon bonds
H0S57_RS08435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S57_RS08440	COG0183	Belongs to the thiolase family
H0S57_RS08445	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S57_RS08450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S57_RS08455	COG3135	benzoate transporter
H0S57_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS08465	COG0543	2 iron, 2 sulfur cluster binding
H0S57_RS08465	COG0633	Ferredoxin
H0S57_RS08470	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S57_RS08475	COG4638	Rieske (2fe-2S)
H0S57_RS08485	COG4829	muconolactone delta-isomerase
H0S57_RS08490	COG4948	Mandelate Racemase Muconate Lactonizing
H0S57_RS08495	COG0583	DNA-binding transcription factor activity
H0S57_RS08500	COG2814	Major facilitator Superfamily
H0S57_RS08590	COG0583	DNA-binding transcription factor activity
H0S57_RS08680	COG0596	Alpha beta hydrolase
H0S57_RS08750	COG0864	Transcriptional regulator
H0S57_RS08775	COG2814	Major facilitator Superfamily
H0S57_RS08830	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS08835	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS08875	COG3293	Transposase
H0S57_RS08895	COG0552	protein localization to endoplasmic reticulum
H0S57_RS08900	COG0612	Peptidase, M16
H0S57_RS08930	COG0517	IMP dehydrogenase activity
H0S57_RS08930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S57_RS08935	COG0133	tryptophan synthase activity
H0S57_RS08945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S57_RS08960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H0S57_RS08965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S57_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS09010	COG0537	adenosine 5'-monophosphoramidase activity
H0S57_RS09035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S57_RS09040	COG0776	regulation of translation
H0S57_RS09055	COG1959	2 iron, 2 sulfur cluster binding
H0S57_RS09065	COG0822	iron-sulfur transferase activity
H0S57_RS09070	COG0316	Belongs to the HesB IscA family
H0S57_RS09100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S57_RS09110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S57_RS09125	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S57_RS09125	COG0506	proline dehydrogenase activity
H0S57_RS09125	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S57_RS09155	COG3781	membrane
H0S57_RS09160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S57_RS09185	COG0697	spore germination
H0S57_RS09200	COG0126	phosphoglycerate kinase activity
H0S57_RS09210	COG0424	maF-like protein
H0S57_RS09220	COG2850	peptidyl-arginine hydroxylation
H0S57_RS09225	COG4585	Histidine kinase
H0S57_RS09230	COG2197	response regulator
H0S57_RS09260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S57_RS09270	COG0824	Thioesterase
H0S57_RS09275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0S57_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS09300	COG0183	Belongs to the thiolase family
H0S57_RS09315	COG0583	DNA-binding transcription factor activity
H0S57_RS09320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S57_RS09330	COG3135	benzoate transporter
H0S57_RS09335	COG1309	transcriptional regulator
H0S57_RS09340	COG2076	Multidrug Resistance protein
H0S57_RS09355	COG0589	response to stress
H0S57_RS09365	COG0308	aminopeptidase N
H0S57_RS09390	COG1253	flavin adenine dinucleotide binding
H0S57_RS09410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S57_RS09415	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S57_RS09430	COG2431	L-lysine efflux transmembrane transporter activity
H0S57_RS09455	COG0776	regulation of translation
H0S57_RS09475	COG0590	tRNA wobble adenosine to inosine editing
H0S57_RS09485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0S57_RS09495	COG3156	type II secretion system protein K
H0S57_RS09520	COG0084	hydrolase, TatD family'
H0S57_RS09540	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S57_RS09545	COG1132	(ABC) transporter
H0S57_RS09555	COG0811	peptide transport
H0S57_RS09560	COG1475	DNA binding
H0S57_RS09565	COG1192	Involved in chromosome partitioning
H0S57_RS09575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S57_RS09590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S57_RS09595	COG3293	Transposase
H0S57_RS09600	COG1923	regulation of RNA biosynthetic process
H0S57_RS09610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S57_RS09615	COG0802	atpase or kinase
H0S57_RS09620	COG0564	pseudouridine synthase activity
H0S57_RS09640	COG2707	UPF0756 membrane protein
H0S57_RS09645	COG2814	Major facilitator Superfamily
H0S57_RS09650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S57_RS09655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S57_RS09665	COG1454	alcohol dehydrogenase
H0S57_RS09685	COG0531	amino acid
H0S57_RS09690	COG4303	Ethanolamine ammonia lyase large subunit
H0S57_RS09695	COG4302	ethanolamine ammonia-lyase activity
H0S57_RS09705	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS09715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S57_RS09715	COG0519	Catalyzes the synthesis of GMP from XMP
H0S57_RS09735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S57_RS09740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0S57_RS09785	COG0352	thiamine-phosphate diphosphorylase activity
H0S57_RS09820	COG0612	Peptidase, M16
H0S57_RS09830	COG1823	symporter activity
H0S57_RS09835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_RS09875	COG2351	hydroxyisourate hydrolase activity
H0S57_RS09885	COG1686	Belongs to the peptidase S11 family
H0S57_RS09890	COG1252	NADH dehydrogenase
H0S57_RS09895	COG1047	Peptidyl-prolyl cis-trans
H0S57_RS09900	COG1254	Belongs to the acylphosphatase family
H0S57_RS09905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S57_RS09905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S57_RS09925	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_RS09930	COG2819	hydrolase of the alpha beta superfamily
H0S57_RS09940	COG0372	Belongs to the citrate synthase family
H0S57_RS09970	COG0542	response to heat
H0S57_RS09975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S57_RS09990	COG3706	GGDEF domain
H0S57_RS10000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0S57_RS10005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S57_RS10015	COG0569	domain protein
H0S57_RS10020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S57_RS10040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S57_RS10050	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S57_RS10065	COG1294	oxidase, subunit
H0S57_RS10070	COG4890	Cyd operon protein YbgT
H0S57_RS10085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S57_RS10090	COG1309	transcriptional regulator
H0S57_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
H0S57_RS10105	COG0579	oxidoreductase
H0S57_RS10120	COG0772	Belongs to the SEDS family
H0S57_RS10135	COG0148	phosphopyruvate hydratase activity
H0S57_RS10155	COG0583	DNA-binding transcription factor activity
H0S57_RS10165	COG2814	Major facilitator Superfamily
H0S57_RS10180	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S57_RS10180	COG1902	pentaerythritol trinitrate reductase activity
H0S57_RS10190	COG2267	carboxylic ester hydrolase activity
H0S57_RS10200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S57_RS10205	COG0702	epimerase
H0S57_RS10250	COG1011	Hydrolase
H0S57_RS10255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S57_RS10260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0S57_RS10265	COG2137	regulation of response to DNA damage stimulus
H0S57_RS10290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S57_RS10310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S57_RS10325	COG0575	Belongs to the CDS family
H0S57_RS10330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S57_RS10350	COG3852	Histidine kinase
H0S57_RS10370	COG0583	DNA-binding transcription factor activity
H0S57_RS10375	COG0024	Methionine aminopeptidase
H0S57_RS10400	COG1113	amino acid transport
H0S57_RS10410	COG0786	glutamate:sodium symporter activity
H0S57_RS10415	COG4773	Receptor
H0S57_RS10465	COG0729	surface antigen
H0S57_RS10490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H0S57_RS10500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0S57_RS10505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S57_RS10510	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS10540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_RS10545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S57_RS10550	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S57_RS10555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0S57_RS10570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S57_RS10600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0S57_RS10605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S57_RS10610	COG1845	cytochrome c oxidase, subunit III
H0S57_RS10615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S57_RS10635	COG0360	Binds together with S18 to 16S ribosomal RNA
H0S57_RS10650	COG0305	Participates in initiation and elongation during chromosome replication
H0S57_RS10655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S57_RS10670	COG1305	Transglutaminase-like
H0S57_RS10680	COG2308	Evidence 4 Homologs of previously reported genes of
H0S57_RS10695	COG0445	tRNA wobble uridine modification
H0S57_RS10725	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S57_RS10730	COG0138	bifunctional purine biosynthesis protein purh
H0S57_RS10735	COG0151	Belongs to the GarS family
H0S57_RS10745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S57_RS10750	COG2011	ABC-type metal ion transport system permease component
H0S57_RS10790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S57_RS10800	COG4122	O-methyltransferase activity
H0S57_RS10820	COG1137	ATPase activity
H0S57_RS10825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S57_RS10835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S57_RS10840	COG0517	IMP dehydrogenase activity
H0S57_RS10840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S57_RS10850	COG0406	alpha-ribazole phosphatase activity
H0S57_RS10855	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0S57_RS10890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S57_RS10900	COG0243	molybdopterin cofactor binding
H0S57_RS10905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_RS10910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_RS10910	COG2146	nitrite reductase [NAD(P)H] activity
H0S57_RS10915	COG2223	nitrite transmembrane transporter activity
H0S57_RS10925	COG1116	anion transmembrane transporter activity
H0S57_RS10925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_RS10945	COG1643	Atp-dependent helicase
H0S57_RS10955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S57_RS10995	COG0515	serine threonine protein kinase
H0S57_RS10995	COG2815	serine threonine protein kinase
H0S57_RS11025	COG1610	YqeY-like protein
H0S57_RS11030	COG4783	chaperone-mediated protein folding
H0S57_RS11060	COG0167	dihydroorotate dehydrogenase activity
H0S57_RS11085	COG0778	Nitroreductase
H0S57_RS11095	COG0513	Belongs to the DEAD box helicase family
H0S57_RS11100	COG1278	Cold shock
H0S57_RS11115	COG2363	Small membrane protein
H0S57_RS11145	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S57_RS11150	COG0625	glutathione transferase activity
H0S57_RS11155	COG0659	secondary active sulfate transmembrane transporter activity
H0S57_RS11165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S57_RS11195	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_RS11200	COG1309	transcriptional regulator
H0S57_RS11205	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS11210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S57_RS11220	COG4770	biotin carboxylase activity
H0S57_RS11235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S57_RS11240	COG2031	fatty acid transporter
H0S57_RS11260	COG0540	Belongs to the ATCase OTCase family
H0S57_RS11280	COG0542	response to heat
H0S57_RS11285	COG1765	OsmC-like protein
H0S57_RS11295	COG0667	Aldo Keto reductase
H0S57_RS11310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S57_RS11325	COG1522	sequence-specific DNA binding
H0S57_RS11330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S57_RS11345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0S57_RS11355	COG0527	aspartate kinase activity
H0S57_RS11365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S57_RS11390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S57_RS11395	COG2252	PERMEase
H0S57_RS11405	COG0415	Belongs to the DNA photolyase family
H0S57_RS11435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S57_RS11440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0S57_RS11450	COG0693	protein deglycase activity
H0S57_RS11455	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS11460	COG1301	dicarboxylic acid transport
H0S57_RS11475	COG3139	Protein of unknown function (DUF1315)
H0S57_RS11480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S57_RS11485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S57_RS11495	COG0494	nUDIX hydrolase
H0S57_RS11505	COG0642	Histidine kinase
H0S57_RS11520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0S57_RS11540	COG1720	tRNA m6t6A37 methyltransferase activity
H0S57_RS11600	COG0826	peptidase U32
H0S57_RS11605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S57_RS11610	COG3634	alkyl hydroperoxide reductase activity
H0S57_RS11630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S57_RS11695	COG0697	spore germination
H0S57_RS11700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S57_RS11705	COG0235	Class ii aldolase
H0S57_RS11710	COG2169	Transcriptional regulator
H0S57_RS11755	COG4149	molybdate abc transporter
H0S57_RS11760	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S57_RS11770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0S57_RS11775	COG0243	molybdopterin cofactor binding
H0S57_RS11780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S57_RS11785	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S57_RS11785	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S57_RS11790	COG0303	'Molybdopterin
H0S57_RS11810	COG2365	Tyrosine phosphatase family
H0S57_RS11815	COG3293	Transposase
H0S57_RS11830	COG1131	(ABC) transporter
H0S57_RS11835	COG0842	Transport permease protein
H0S57_RS11850	COG2951	lytic endotransglycosylase activity
H0S57_RS11885	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S57_RS11905	COG2175	clavaminate synthase activity
H0S57_RS11920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S57_RS11925	COG0842	Transport permease protein
H0S57_RS11965	COG1522	sequence-specific DNA binding
H0S57_RS11970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S57_RS11980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S57_RS11990	COG0019	diaminopimelate decarboxylase activity
H0S57_RS12000	COG1113	amino acid transport
H0S57_RS12005	COG1115	amino acid carrier protein
H0S57_RS12020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S57_RS12025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S57_RS12030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S57_RS12035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S57_RS12075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S57_RS12080	COG3161	chorismate lyase activity
H0S57_RS12090	COG0174	glutamine synthetase
H0S57_RS12095	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S57_RS12100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S57_RS12105	COG0134	indole-3-glycerol-phosphate synthase activity
H0S57_RS12120	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_RS12125	COG0300	oxidoreductase activity
H0S57_RS12135	COG0302	gtp cyclohydrolase
H0S57_RS12160	COG3739	integral membrane protein
H0S57_RS12180	COG1741	Belongs to the pirin family
H0S57_RS12195	COG1309	transcriptional regulator
H0S57_RS12205	COG5006	permease, DMT superfamily
H0S57_RS12210	COG0697	spore germination
H0S57_RS12230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S57_RS12235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H0S57_RS12245	COG0037	tRNA processing
H0S57_RS12250	COG0741	lytic transglycosylase activity
H0S57_RS12255	COG0501	Belongs to the peptidase M48B family
H0S57_RS12270	COG2239	Acts as a magnesium transporter
H0S57_RS12300	COG1253	flavin adenine dinucleotide binding
H0S57_RS12305	COG2851	Citrate transporter
H0S57_RS12345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S57_RS12350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S57_RS12375	COG0505	Belongs to the CarA family
H0S57_RS12380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0S57_RS12405	COG3695	enzyme binding
H0S57_RS12420	COG2321	neutral zinc metallopeptidase
H0S57_RS12425	COG2354	Protein conserved in bacteria
H0S57_RS12435	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S57_RS12440	COG2268	Band 7 protein
H0S57_RS12450	COG0726	polysaccharide deacetylase
H0S57_RS12450	COG1649	PFAM Uncharacterised BCR, COG1649
H0S57_RS12460	COG1215	transferase activity, transferring glycosyl groups
H0S57_RS12465	COG0726	polysaccharide deacetylase
H0S57_RS12465	COG1649	PFAM Uncharacterised BCR, COG1649
H0S57_RS12475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0S57_RS12485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S57_RS12500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S57_RS12505	COG1053	succinate dehydrogenase
H0S57_RS12510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S57_RS12515	COG2009	succinate dehydrogenase
H0S57_RS12530	COG0300	oxidoreductase activity
H0S57_RS12545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0S57_RS12545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_RS12570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S57_RS12595	COG0564	pseudouridine synthase activity
H0S57_RS12605	COG0358	DNA primase activity
H0S57_RS12620	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0S57_RS12650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S57_RS12655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0S57_RS12705	COG0586	Pfam SNARE associated Golgi protein
H0S57_RS12715	COG0583	DNA-binding transcription factor activity
H0S57_RS12740	COG2921	Belongs to the UPF0250 family
H0S57_RS12745	COG0321	lipoyl(octanoyl) transferase activity
H0S57_RS12765	COG0531	amino acid
H0S57_RS12785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S57_RS12790	COG1648	precorrin-2 dehydrogenase activity
H0S57_RS12790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S57_RS12795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0S57_RS12805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S57_RS12815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0S57_RS12835	COG0671	phosphoesterase, PA-phosphatase related
H0S57_RS12840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S57_RS12850	COG1538	Outer membrane efflux protein
H0S57_RS12855	COG0393	Putative heavy-metal-binding
H0S57_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS12880	COG0525	valine-tRNA ligase activity
H0S57_RS12920	COG0583	DNA-binding transcription factor activity
H0S57_RS12925	COG1278	Cold shock
H0S57_RS12930	COG1278	Cold shock
H0S57_RS12945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S57_RS12950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S57_RS12955	COG0713	ATP synthesis coupled electron transport
H0S57_RS12965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S57_RS12980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S57_RS13000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S57_RS13010	COG2205	protein histidine kinase activity
H0S57_RS13015	COG0745	RESPONSE REGULATOR receiver
H0S57_RS13030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S57_RS13050	COG0535	radical SAM domain protein
H0S57_RS13155	COG0439	Biotin carboxylase
H0S57_RS13160	COG1802	Transcriptional regulator
H0S57_RS13165	COG1652	LysM domain
H0S57_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS13190	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S57_RS13195	COG3101	peptidyl-lysine hydroxylation
H0S57_RS13200	COG0009	L-threonylcarbamoyladenylate synthase
H0S57_RS13215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S57_RS13220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S57_RS13260	COG4206	TonB-dependent receptor
H0S57_RS13290	COG4106	trans-aconitate 2-methyltransferase activity
H0S57_RS13305	COG2267	carboxylic ester hydrolase activity
H0S57_RS13310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S57_RS13315	COG2193	ferroxidase activity
H0S57_RS13335	COG4774	siderophore transport
H0S57_RS13340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S57_RS13345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0S57_RS13350	COG3115	cell septum assembly
H0S57_RS13355	COG1196	nuclear chromosome segregation
H0S57_RS13365	COG0730	response to heat
H0S57_RS13385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S57_RS13400	COG0488	(ABC) transporter
H0S57_RS13415	COG0494	nUDIX hydrolase
H0S57_RS13425	COG3422	double-strand break repair
H0S57_RS13435	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S57_RS13440	COG3189	MarR family transcriptional regulator
H0S57_RS13460	COG0564	pseudouridine synthase activity
H0S57_RS13465	COG0346	lactoylglutathione lyase activity
H0S57_RS13510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0S57_RS13540	COG1902	pentaerythritol trinitrate reductase activity
H0S57_RS13545	COG3659	wide pore channel activity
H0S57_RS13555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S57_RS13565	COG1970	mechanosensitive ion channel activity
H0S57_RS13570	COG1217	gtp-binding protein TYPA
H0S57_RS13575	COG2233	PERMEase
H0S57_RS13580	COG2813	Specifically methylates the guanine in position
H0S57_RS13585	COG0833	amino acid
H0S57_RS13600	COG0183	Belongs to the thiolase family
H0S57_RS13625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_RS13640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S57_RS13645	COG2207	Transcriptional regulator
H0S57_RS13650	COG0183	Belongs to the thiolase family
H0S57_RS13655	COG1024	Enoyl-CoA hydratase
H0S57_RS13655	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S57_RS13680	COG1272	protein, Hemolysin III
H0S57_RS13685	COG0477	Major facilitator Superfamily
H0S57_RS13695	COG1408	metallophosphoesterase
H0S57_RS13700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S57_RS13710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S57_RS13735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S57_RS13740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S57_RS13745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0S57_RS13750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S57_RS13755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S57_RS13765	COG0625	glutathione transferase activity
H0S57_RS13770	COG2969	positive regulation of protein catabolic process
H0S57_RS13830	COG2199	diguanylate cyclase activity
H0S57_RS13860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S57_RS13865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S57_RS13885	COG0450	alkyl hydroperoxide reductase
H0S57_RS13905	COG0285	dihydrofolate synthase activity
H0S57_RS13955	COG4206	TonB-dependent receptor
H0S57_RS13960	COG2096	Adenosyltransferase
H0S57_RS13980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0S57_RS13985	COG2315	Protein conserved in bacteria
H0S57_RS14000	COG1113	amino acid transport
H0S57_RS14005	COG0745	RESPONSE REGULATOR receiver
H0S57_RS14010	COG2205	protein histidine kinase activity
H0S57_RS14020	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS14025	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS14030	COG3223	Belongs to the PsiE family
H0S57_RS14065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0S57_RS14090	COG3306	glycosyltransferase involved in LPS biosynthesis
H0S57_RS14115	COG0438	transferase activity, transferring glycosyl groups
H0S57_RS14150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S57_RS14155	COG5002	protein histidine kinase activity
H0S57_RS14165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0S57_RS14175	COG1704	LemA family
H0S57_RS14185	COG1862	Preprotein translocase
H0S57_RS14210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S57_RS14230	COG1426	Protein conserved in bacteria
H0S57_RS14290	COG0440	acetolactate synthase activity
H0S57_RS14295	COG0028	Belongs to the TPP enzyme family
H0S57_RS14320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S57_RS14325	COG1136	(ABC) transporter
H0S57_RS14325	COG0577	efflux transmembrane transporter activity
H0S57_RS14330	COG1538	Outer membrane efflux protein
H0S57_RS14365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S57_RS14370	COG1162	GTPase activity
H0S57_RS14395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S57_RS14405	COG3781	membrane
H0S57_RS14410	COG0613	PHP domain protein
H0S57_RS14420	COG2350	Protein conserved in bacteria
H0S57_RS14440	COG1666	GTP binding
H0S57_RS14455	COG1607	acyl-coa hydrolase
H0S57_RS14515	COG1183	phosphatidylcholine synthase activity
H0S57_RS14520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S57_RS14545	COG0039	L-malate dehydrogenase activity
H0S57_RS14555	COG1196	nuclear chromosome segregation
H0S57_RS14555	COG0739	heme binding
H0S57_RS14555	COG0741	lytic transglycosylase activity
H0S57_RS14560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0S57_RS14565	COG1702	phosphate starvation-inducible protein PhoH
H0S57_RS14570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0S57_RS14600	COG3293	Transposase
H0S57_RS14620	COG1295	ribonuclease BN
H0S57_RS14635	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S57_RS14670	COG0557	exoribonuclease II activity
H0S57_RS14675	COG2720	vancomycin resistance protein
H0S57_RS14680	COG0339	signal peptide processing
H0S57_RS14685	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S57_RS14725	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S57_RS14730	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS14735	COG2267	carboxylic ester hydrolase activity
H0S57_RS14740	COG2072	flavoprotein involved in K transport
H0S57_RS14745	COG0203	ribosomal protein L17
H0S57_RS14750	COG0202	RNA polymerase activity
H0S57_RS14765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0S57_RS14790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0S57_RS14800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0S57_RS14805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0S57_RS14855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0S57_RS14870	COG0088	Forms part of the polypeptide exit tunnel
H0S57_RS14875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0S57_RS14895	COG0433	COG0433 Predicted ATPase
H0S57_RS14905	COG1959	2 iron, 2 sulfur cluster binding
H0S57_RS14920	COG1301	dicarboxylic acid transport
H0S57_RS14925	COG1946	Acyl-CoA thioesterase
H0S57_RS14930	COG2937	Belongs to the GPAT DAPAT family
H0S57_RS14940	COG3293	Transposase
H0S57_RS14965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S57_RS14970	COG1040	competence protein
H0S57_RS14975	COG0494	nUDIX hydrolase
H0S57_RS14985	COG0598	Magnesium transport protein CorA
H0S57_RS14995	COG2854	intermembrane phospholipid transfer
H0S57_RS15000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S57_RS15005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S57_RS15010	COG1127	ABC transporter
H0S57_RS15015	COG0513	Belongs to the DEAD box helicase family
H0S57_RS15035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S57_RS15040	COG0408	coproporphyrinogen oxidase activity
H0S57_RS15060	COG1960	acyl-CoA dehydrogenase activity
H0S57_RS15095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S57_RS15105	COG0534	Mate efflux family protein
H0S57_RS15115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S57_RS15120	COG0254	rRNA binding
H0S57_RS15125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0S57_RS15140	COG2226	methyltransferase
H0S57_RS15150	COG1192	Involved in chromosome partitioning
H0S57_RS15155	COG0628	permease
H0S57_RS15160	COG2032	superoxide dismutase activity
H0S57_RS15165	COG1289	transmembrane transporter activity
H0S57_RS15170	COG2814	Major facilitator Superfamily
H0S57_RS15185	COG2131	deaminase
H0S57_RS15190	COG3293	Transposase
H0S57_RS15205	COG0277	FAD linked oxidase domain protein
H0S57_RS15210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S57_RS15215	COG5006	permease, DMT superfamily
H0S57_RS15235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S57_RS15240	COG5380	lipid catabolic process
H0S57_RS15255	COG0335	large ribosomal subunit rRNA binding
H0S57_RS15265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S57_RS15310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H0S57_RS15315	COG0194	GDP metabolic process
H0S57_RS15320	COG1758	RNA polymerase activity
H0S57_RS15325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S57_RS15345	COG3307	-O-antigen
H0S57_RS15365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0S57_RS15370	COG1704	LemA family
H0S57_RS15380	COG0493	'glutamate synthase
H0S57_RS15385	COG0067	glutamate synthase
H0S57_RS15385	COG0070	glutamate synthase
H0S57_RS15385	COG0069	glutamate synthase activity
H0S57_RS15435	COG2226	methyltransferase
H0S57_RS15445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S57_RS15450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S57_RS15470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S57_RS15485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S57_RS15505	COG0488	(ABC) transporter
H0S57_RS15510	COG2873	o-acetylhomoserine
H0S57_RS15515	COG4221	oxidoreductase activity
H0S57_RS15545	COG0427	acetyl-CoA hydrolase
H0S57_RS15580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S57_RS15610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S57_RS15615	COG0531	amino acid
H0S57_RS15640	COG1278	Cold shock
H0S57_RS15645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S57_RS15705	COG2132	Multicopper oxidase
H0S57_RS15720	COG2205	protein histidine kinase activity
H0S57_RS15760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S57_RS15765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H0S57_RS15795	COG3293	Transposase
H0S57_RS15800	COG0753	catalase activity
H0S57_RS15810	COG3077	Addiction module antitoxin, RelB DinJ family
H0S57_RS15845	COG3842	ATPase activity
H0S57_RS15850	COG1840	ABC-type Fe3 transport system, periplasmic component
H0S57_RS15960	COG0582	viral genome integration into host DNA
H0S57_RS16005	COG4942	peptidase
H0S57_RS16070	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H0S57_RS16080	COG1335	isochorismatase
H0S57_RS16110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_RS16125	COG1301	dicarboxylic acid transport
H0S57_RS16130	COG0583	DNA-binding transcription factor activity
H0S57_RS16140	COG0629	single-stranded DNA binding
H0S57_RS16175	COG3293	Transposase
H0S57_RS16180	COG0629	single-stranded DNA binding
H0S57_RS16185	COG2814	Major facilitator Superfamily
H0S57_RS16195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S57_RS16195	COG0352	thiamine-phosphate diphosphorylase activity
H0S57_RS16195	COG0351	phosphomethylpyrimidine kinase
H0S57_RS16220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S57_RS16230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S57_RS16235	COG3162	membrane
H0S57_RS16240	COG2205	protein histidine kinase activity
H0S57_RS16240	COG0784	Response regulator, receiver
H0S57_RS16255	COG0431	NADPH-dependent FMN reductase
H0S57_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_RS16275	COG0307	riboflavin synthase, alpha
H0S57_RS16280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S57_RS16285	COG0668	transmembrane transport
H0S57_RS16290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S57_RS16295	COG1519	Transferase
H0S57_RS16300	COG1902	pentaerythritol trinitrate reductase activity
H0S57_RS16325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S57_RS16350	COG0426	domain, Protein
H0S57_RS16350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_RS16355	COG2119	membrane
H0S57_RS16385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0S57_RS16395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S57_RS16405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S57_RS16420	COG0189	ligase activity
H0S57_RS16425	COG0386	Belongs to the glutathione peroxidase family
H0S57_RS16430	COG1846	Transcriptional regulator
H0S57_RS16445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S57_RS16455	COG0708	Exodeoxyribonuclease III
H0S57_RS16460	COG1393	Belongs to the ArsC family
H0S57_RS16475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H0S57_RS16560	COG3150	esterase
H0S57_RS16570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H0S57_RS16575	COG2918	glutathione biosynthetic process
H0S57_RS16590	COG2733	membrane
H0S57_RS16595	COG0436	Aminotransferase
H0S57_RS16600	COG0534	Mate efflux family protein
H0S57_RS16675	COG0385	Bile acid
H0S57_RS16680	COG1335	isochorismatase
H0S57_RS16685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S57_RS16700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S57_RS16705	COG4215	(ABC) transporter
H0S57_RS16710	COG4160	amino acid transport
H0S57_RS16730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0S57_RS16735	COG2983	Belongs to the UPF0260 family
H0S57_RS16740	COG5487	UPF0391 membrane protein
H0S57_RS16770	COG2818	Glycosylase
H0S57_RS16775	COG1064	alcohol dehydrogenase
H0S57_RS16780	COG0436	Aminotransferase
H0S57_RS16795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0S57_RS16825	COG1309	transcriptional regulator
H0S57_RS16835	COG2233	PERMEase
H0S57_RS16840	COG0583	DNA-binding transcription factor activity
H0S57_RS16850	COG4774	siderophore transport
H0S57_RS16860	COG0129	dihydroxy-acid dehydratase activity
H0S57_RS16880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0S57_RS16880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0S57_RS16910	COG0733	neurotransmitter:sodium symporter activity
H0S57_RS16920	COG2814	Major facilitator Superfamily
H0S57_RS16950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S57_RS16955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S57_RS16960	COG2951	lytic endotransglycosylase activity
H0S57_RS16965	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S57_RS16980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S57_RS17000	COG0861	Integral membrane protein TerC family
H0S57_RS17010	COG0754	glutathionylspermidine amidase activity
H0S57_RS17020	COG0402	S-adenosylhomocysteine deaminase activity
H0S57_RS17040	COG1230	cation diffusion facilitator family transporter
H0S57_RS17055	COG0583	DNA-binding transcription factor activity
H0S57_RS17070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S57_RS17075	COG0281	malic enzyme
H0S57_RS17085	COG0706	membrane insertase activity
H0S57_RS17090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane