locus-tag	class	description
I6I51_RS00015	COG4372	Transposase
I6I51_RS00030	COG2132	Multicopper oxidase
I6I51_RS00045	COG2205	protein histidine kinase activity
I6I51_RS00065	COG4372	Transposase
I6I51_RS00075	COG2217	Heavy metal translocating P-type atpase
I6I51_RS00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I51_RS00150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I51_RS00175	COG1192	Involved in chromosome partitioning
I6I51_RS00295	COG0589	response to stress
I6I51_RS00300	COG0659	secondary active sulfate transmembrane transporter activity
I6I51_RS00355	COG0842	Transport permease protein
I6I51_RS00360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_RS00375	COG2175	clavaminate synthase activity
I6I51_RS00395	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I51_RS00430	COG2951	lytic endotransglycosylase activity
I6I51_RS00445	COG0842	Transport permease protein
I6I51_RS00450	COG1131	(ABC) transporter
I6I51_RS00460	COG0303	'Molybdopterin
I6I51_RS00465	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I51_RS00465	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I51_RS00480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I51_RS00490	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I51_RS00495	COG4149	molybdate abc transporter
I6I51_RS00520	COG0235	Class ii aldolase
I6I51_RS00530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I51_RS00540	COG3293	Transposase
I6I51_RS00545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I51_RS00545	COG0475	glutathione-regulated potassium exporter activity
I6I51_RS00550	COG3706	GGDEF domain
I6I51_RS00615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I51_RS00640	COG3634	alkyl hydroperoxide reductase activity
I6I51_RS00645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I51_RS00650	COG0826	peptidase U32
I6I51_RS00685	COG1720	tRNA m6t6A37 methyltransferase activity
I6I51_RS00705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I51_RS00720	COG0642	Histidine kinase
I6I51_RS00730	COG0494	nUDIX hydrolase
I6I51_RS00740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I51_RS00745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I51_RS00750	COG3139	Protein of unknown function (DUF1315)
I6I51_RS00760	COG1301	dicarboxylic acid transport
I6I51_RS00770	COG0693	protein deglycase activity
I6I51_RS00780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I51_RS00785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I51_RS00835	COG0415	Belongs to the DNA photolyase family
I6I51_RS00845	COG2252	PERMEase
I6I51_RS00850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I51_RS00860	COG3038	cytochrome b561
I6I51_RS00875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I51_RS00885	COG0527	aspartate kinase activity
I6I51_RS00890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I51_RS00895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I51_RS00910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I51_RS00915	COG1522	sequence-specific DNA binding
I6I51_RS00930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I51_RS00945	COG0667	Aldo Keto reductase
I6I51_RS00955	COG1765	OsmC-like protein
I6I51_RS00980	COG0540	Belongs to the ATCase OTCase family
I6I51_RS01045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I51_RS01055	COG0659	secondary active sulfate transmembrane transporter activity
I6I51_RS01060	COG0625	glutathione transferase activity
I6I51_RS01065	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I51_RS01090	COG2363	Small membrane protein
I6I51_RS01105	COG1278	Cold shock
I6I51_RS01110	COG0513	Belongs to the DEAD box helicase family
I6I51_RS01120	COG0778	Nitroreductase
I6I51_RS01175	COG4783	chaperone-mediated protein folding
I6I51_RS01180	COG1610	YqeY-like protein
I6I51_RS01210	COG0515	serine threonine protein kinase
I6I51_RS01210	COG2815	serine threonine protein kinase
I6I51_RS01250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I51_RS01260	COG1643	Atp-dependent helicase
I6I51_RS01280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I51_RS01280	COG1116	anion transmembrane transporter activity
I6I51_RS01290	COG2223	nitrite transmembrane transporter activity
I6I51_RS01295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_RS01300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_RS01305	COG0243	molybdopterin cofactor binding
I6I51_RS01315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I51_RS01350	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I51_RS01355	COG0406	alpha-ribazole phosphatase activity
I6I51_RS01365	COG0517	IMP dehydrogenase activity
I6I51_RS01365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I51_RS01370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I51_RS01380	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I51_RS01385	COG1137	ATPase activity
I6I51_RS01405	COG4122	O-methyltransferase activity
I6I51_RS01415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I51_RS01460	COG2011	ABC-type metal ion transport system permease component
I6I51_RS01465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I51_RS01485	COG0151	Belongs to the GarS family
I6I51_RS01490	COG0138	bifunctional purine biosynthesis protein purh
I6I51_RS01495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I51_RS01525	COG0445	tRNA wobble uridine modification
I6I51_RS01540	COG2308	Evidence 4 Homologs of previously reported genes of
I6I51_RS01550	COG1305	Transglutaminase-like
I6I51_RS01565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I51_RS01570	COG0305	Participates in initiation and elongation during chromosome replication
I6I51_RS01585	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I51_RS01605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I51_RS01610	COG1845	cytochrome c oxidase, subunit III
I6I51_RS01615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I51_RS01620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I51_RS01650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I51_RS01665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I51_RS01670	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I51_RS01675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I51_RS01680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I51_RS01715	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS01720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I51_RS01735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I51_RS01760	COG0729	surface antigen
I6I51_RS01810	COG1113	amino acid transport
I6I51_RS01835	COG0024	Methionine aminopeptidase
I6I51_RS01840	COG0583	DNA-binding transcription factor activity
I6I51_RS01845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I51_RS01860	COG3852	Histidine kinase
I6I51_RS01880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I51_RS01885	COG0575	Belongs to the CDS family
I6I51_RS01900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I51_RS01920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I51_RS01935	COG2137	regulation of response to DNA damage stimulus
I6I51_RS01940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I51_RS01945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I51_RS01950	COG1011	Hydrolase
I6I51_RS01985	COG3293	Transposase
I6I51_RS02000	COG0702	epimerase
I6I51_RS02005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I51_RS02055	COG2814	Major facilitator Superfamily
I6I51_RS02065	COG0583	DNA-binding transcription factor activity
I6I51_RS02085	COG0148	phosphopyruvate hydratase activity
I6I51_RS02100	COG0772	Belongs to the SEDS family
I6I51_RS02115	COG0579	oxidoreductase
I6I51_RS02125	COG1012	belongs to the aldehyde dehydrogenase family
I6I51_RS02130	COG1309	transcriptional regulator
I6I51_RS02135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I51_RS02150	COG4890	Cyd operon protein YbgT
I6I51_RS02155	COG1294	oxidase, subunit
I6I51_RS02170	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I51_RS02180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I51_RS02200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I51_RS02205	COG0569	domain protein
I6I51_RS02215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I51_RS02220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I51_RS02245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I51_RS02250	COG0542	response to heat
I6I51_RS02280	COG0372	Belongs to the citrate synthase family
I6I51_RS02310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I51_RS02315	COG0730	response to heat
I6I51_RS02330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I51_RS02335	COG1944	ATP diphosphatase activity
I6I51_RS02345	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I51_RS02350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I51_RS02385	COG2223	nitrite transmembrane transporter activity
I6I51_RS02400	COG1346	cytolysis
I6I51_RS02405	COG1380	Effector of murein hydrolase LrgA
I6I51_RS02410	COG0583	DNA-binding transcription factor activity
I6I51_RS02415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I51_RS02445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I51_RS02465	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS02480	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I51_RS02525	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I51_RS02540	COG5001	Diguanylate cyclase
I6I51_RS02540	COG3300	MHYT domain
I6I51_RS02550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I51_RS02560	COG2814	Major facilitator Superfamily
I6I51_RS02575	COG1132	(ABC) transporter
I6I51_RS02590	COG0668	transmembrane transport
I6I51_RS02600	COG3122	Protein conserved in bacteria
I6I51_RS02620	COG0640	Transcriptional regulator
I6I51_RS02625	COG0596	Alpha beta hydrolase
I6I51_RS02635	COG1335	isochorismatase
I6I51_RS02640	COG0251	oxidation-reduction process
I6I51_RS02645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_RS02650	COG2233	PERMEase
I6I51_RS02660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I51_RS02670	COG0183	Belongs to the thiolase family
I6I51_RS02675	COG0583	DNA-binding transcription factor activity
I6I51_RS02690	COG0439	Biotin carboxylase
I6I51_RS02705	COG0511	ligase activity, forming carbon-carbon bonds
I6I51_RS02715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I51_RS02720	COG0183	Belongs to the thiolase family
I6I51_RS02725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I51_RS02730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I51_RS02735	COG3135	benzoate transporter
I6I51_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_RS02745	COG0633	Ferredoxin
I6I51_RS02745	COG0543	2 iron, 2 sulfur cluster binding
I6I51_RS02750	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I51_RS02755	COG4638	Rieske (2fe-2S)
I6I51_RS02765	COG4829	muconolactone delta-isomerase
I6I51_RS02770	COG4948	Mandelate Racemase Muconate Lactonizing
I6I51_RS02775	COG0583	DNA-binding transcription factor activity
I6I51_RS02780	COG2814	Major facilitator Superfamily
I6I51_RS02875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I51_RS02880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I51_RS02885	COG0022	dehydrogenase e1 component
I6I51_RS02890	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I51_RS02895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I51_RS02905	COG1063	alcohol dehydrogenase
I6I51_RS03010	COG4372	Transposase
I6I51_RS03170	COG2801	Transposase and inactivated derivatives
I6I51_RS03275	COG0596	Alpha beta hydrolase
I6I51_RS03345	COG0864	Transcriptional regulator
I6I51_RS03370	COG2814	Major facilitator Superfamily
I6I51_RS03425	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS03430	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS03490	COG0552	protein localization to endoplasmic reticulum
I6I51_RS03495	COG0612	Peptidase, M16
I6I51_RS03520	COG0517	IMP dehydrogenase activity
I6I51_RS03520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I51_RS03530	COG0133	tryptophan synthase activity
I6I51_RS03540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I51_RS03555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I51_RS03560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I51_RS03590	COG0537	adenosine 5'-monophosphoramidase activity
I6I51_RS03615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I51_RS03620	COG0776	regulation of translation
I6I51_RS03635	COG1959	2 iron, 2 sulfur cluster binding
I6I51_RS03645	COG0822	iron-sulfur transferase activity
I6I51_RS03650	COG0316	Belongs to the HesB IscA family
I6I51_RS03680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I51_RS03695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I51_RS03705	COG0506	proline dehydrogenase activity
I6I51_RS03705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I51_RS03705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I51_RS03735	COG3781	membrane
I6I51_RS03740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I51_RS03770	COG0697	spore germination
I6I51_RS03785	COG0126	phosphoglycerate kinase activity
I6I51_RS03795	COG0424	maF-like protein
I6I51_RS03800	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS03805	COG2850	peptidyl-arginine hydroxylation
I6I51_RS03815	COG2197	response regulator
I6I51_RS03820	COG0069	glutamate synthase activity
I6I51_RS03840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I51_RS03845	COG1454	alcohol dehydrogenase
I6I51_RS03850	COG0824	Thioesterase
I6I51_RS03855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I51_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_RS03880	COG0183	Belongs to the thiolase family
I6I51_RS03895	COG0583	DNA-binding transcription factor activity
I6I51_RS03900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I51_RS03910	COG3135	benzoate transporter
I6I51_RS03915	COG1309	transcriptional regulator
I6I51_RS03920	COG2076	Multidrug Resistance protein
I6I51_RS03935	COG0589	response to stress
I6I51_RS03945	COG0308	aminopeptidase N
I6I51_RS03970	COG1253	flavin adenine dinucleotide binding
I6I51_RS03990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I51_RS03995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I51_RS04010	COG2431	L-lysine efflux transmembrane transporter activity
I6I51_RS04025	COG0776	regulation of translation
I6I51_RS04045	COG0590	tRNA wobble adenosine to inosine editing
I6I51_RS04055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I51_RS04090	COG0084	hydrolase, TatD family'
I6I51_RS04110	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I51_RS04115	COG1132	(ABC) transporter
I6I51_RS04125	COG0811	peptide transport
I6I51_RS04130	COG1475	DNA binding
I6I51_RS04135	COG1192	Involved in chromosome partitioning
I6I51_RS04145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I51_RS04150	COG3178	'Phosphotransferase
I6I51_RS04160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I51_RS04165	COG1923	regulation of RNA biosynthetic process
I6I51_RS04175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I51_RS04180	COG0802	atpase or kinase
I6I51_RS04200	COG1187	pseudouridine synthase activity
I6I51_RS04205	COG2707	UPF0756 membrane protein
I6I51_RS04215	COG2814	Major facilitator Superfamily
I6I51_RS04220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I51_RS04225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I51_RS04235	COG1454	alcohol dehydrogenase
I6I51_RS04255	COG0531	amino acid
I6I51_RS04260	COG4303	Ethanolamine ammonia lyase large subunit
I6I51_RS04265	COG4302	ethanolamine ammonia-lyase activity
I6I51_RS04285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I51_RS04285	COG0519	Catalyzes the synthesis of GMP from XMP
I6I51_RS04305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I51_RS04310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I51_RS04360	COG0352	thiamine-phosphate diphosphorylase activity
I6I51_RS04395	COG0612	Peptidase, M16
I6I51_RS04405	COG1823	symporter activity
I6I51_RS04410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_RS04450	COG2351	hydroxyisourate hydrolase activity
I6I51_RS04460	COG1686	Belongs to the peptidase S11 family
I6I51_RS04465	COG1252	NADH dehydrogenase
I6I51_RS04470	COG1047	Peptidyl-prolyl cis-trans
I6I51_RS04475	COG1254	Belongs to the acylphosphatase family
I6I51_RS04480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I51_RS04480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I51_RS04530	COG4372	Transposase
I6I51_RS04585	COG1464	Belongs to the NlpA lipoprotein family
I6I51_RS04590	COG1464	Belongs to the NlpA lipoprotein family
I6I51_RS04595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I51_RS04600	COG2011	ABC-type metal ion transport system permease component
I6I51_RS04605	COG0012	GTP binding
I6I51_RS04630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I51_RS04645	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I51_RS04660	COG0386	Belongs to the glutathione peroxidase family
I6I51_RS04665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I51_RS04670	COG0436	Aminotransferase
I6I51_RS04690	COG3634	alkyl hydroperoxide reductase activity
I6I51_RS04715	COG2070	2-Nitropropane dioxygenase
I6I51_RS04750	COG3293	Transposase
I6I51_RS04790	COG1309	transcriptional regulator
I6I51_RS04815	COG0842	Transport permease protein
I6I51_RS04835	COG0783	Belongs to the Dps family
I6I51_RS04840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I51_RS04870	COG0745	RESPONSE REGULATOR receiver
I6I51_RS04875	COG0642	Histidine kinase
I6I51_RS04890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I51_RS04935	COG2816	NAD+ diphosphatase activity
I6I51_RS04940	COG3046	protein related to deoxyribodipyrimidine photolyase
I6I51_RS04960	COG2351	hydroxyisourate hydrolase activity
I6I51_RS04995	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS05035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I51_RS05040	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS05050	COG0582	viral genome integration into host DNA
I6I51_RS05070	COG0714	Associated with various cellular activities
I6I51_RS05075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I51_RS05080	COG2879	small protein
I6I51_RS05085	COG1966	Carbon starvation protein
I6I51_RS05090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I51_RS05110	COG0254	rRNA binding
I6I51_RS05130	COG1067	ATP-dependent peptidase activity
I6I51_RS05135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I51_RS05140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I51_RS05145	COG0616	signal peptide processing
I6I51_RS05150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I51_RS05160	COG0573	inorganic phosphate transmembrane transporter activity
I6I51_RS05165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I51_RS05170	COG0076	glutamate decarboxylase activity
I6I51_RS05175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I51_RS05190	COG0671	phosphoesterase, PA-phosphatase related
I6I51_RS05195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I51_RS05205	COG1733	regulation of RNA biosynthetic process
I6I51_RS05210	COG0702	epimerase
I6I51_RS05240	COG0556	nucleotide-excision repair
I6I51_RS05255	COG2199	diguanylate cyclase activity
I6I51_RS05265	COG0436	Aminotransferase
I6I51_RS05305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I51_RS05310	COG1381	Involved in DNA repair and RecF pathway recombination
I6I51_RS05320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I51_RS05325	COG0571	ribonuclease III activity
I6I51_RS05335	COG0681	Belongs to the peptidase S26 family
I6I51_RS05350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I51_RS05370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I51_RS05380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I51_RS05395	COG4208	sulfate ABC transporter
I6I51_RS05400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I51_RS05405	COG0583	DNA-binding transcription factor activity
I6I51_RS05415	COG4625	pathogenesis
I6I51_RS05425	COG0602	queuosine metabolic process
I6I51_RS05430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I51_RS05445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I51_RS05450	COG1279	arginine transmembrane transporter activity
I6I51_RS05455	COG0583	DNA-binding transcription factor activity
I6I51_RS05460	COG2353	YceI-like domain
I6I51_RS05465	COG1051	belongs to the nudix hydrolase family
I6I51_RS05465	COG1056	cytidyltransferase-related domain
I6I51_RS05470	COG1024	Enoyl-CoA hydratase
I6I51_RS05475	COG0778	Nitroreductase
I6I51_RS05480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I51_RS05480	COG3323	Protein of unknown function (DUF1653)
I6I51_RS05490	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I51_RS05490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I51_RS05505	COG2255	four-way junction helicase activity
I6I51_RS05530	COG0824	Thioesterase
I6I51_RS05550	COG0823	Involved in the tonB-independent uptake of proteins
I6I51_RS05570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I51_RS05600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I51_RS05605	COG0628	permease
I6I51_RS05610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I51_RS05615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I51_RS05635	COG0658	competence protein
I6I51_RS05635	COG2333	competence protein COMEC
I6I51_RS05640	COG1136	(ABC) transporter
I6I51_RS05645	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I51_RS05660	COG1671	Belongs to the UPF0178 family
I6I51_RS05675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I51_RS05680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I51_RS05735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I51_RS05740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I51_RS05745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I51_RS05750	COG5001	Diguanylate cyclase
I6I51_RS05750	COG1716	ATPase activity
I6I51_RS05755	COG0280	phosphate acetyltransferase
I6I51_RS05755	COG0281	malic enzyme
I6I51_RS05785	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I51_RS05785	COG1902	pentaerythritol trinitrate reductase activity
I6I51_RS05790	COG0277	FAD linked oxidase domain protein
I6I51_RS05800	COG2186	Transcriptional regulator
I6I51_RS05815	COG2203	Gaf domain
I6I51_RS05815	COG3706	GGDEF domain
I6I51_RS05815	COG5001	Diguanylate cyclase
I6I51_RS05815	COG4251	negative regulation of phosphorylation
I6I51_RS05820	COG0418	dihydroorotase activity
I6I51_RS05825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I51_RS05855	COG0833	amino acid
I6I51_RS05880	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6I51_RS05895	COG4172	Belongs to the ABC transporter superfamily
I6I51_RS05900	COG4239	(ABC) transporter, permease
I6I51_RS05905	COG4174	ABC transporter (Permease)
I6I51_RS05910	COG4166	transmembrane transport
I6I51_RS05915	COG1388	LysM domain
I6I51_RS05915	COG0741	lytic transglycosylase activity
I6I51_RS05920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I51_RS05935	COG0657	acetylesterase activity
I6I51_RS05955	COG0583	DNA-binding transcription factor activity
I6I51_RS05960	COG4942	peptidase
I6I51_RS05960	COG1388	LysM domain
I6I51_RS05990	COG0753	catalase activity
I6I51_RS06015	COG1686	Belongs to the peptidase S11 family
I6I51_RS06020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I51_RS06025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I51_RS06030	COG2267	carboxylic ester hydrolase activity
I6I51_RS06035	COG0671	phosphoesterase, PA-phosphatase related
I6I51_RS06035	COG2453	phosphatase
I6I51_RS06050	COG4589	Belongs to the CDS family
I6I51_RS06065	COG2915	High frequency lysogenization protein hflD homolog
I6I51_RS06085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I51_RS06090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I51_RS06100	COG2801	Transposase and inactivated derivatives
I6I51_RS06110	COG0006	proline dipeptidase activity
I6I51_RS06135	COG4770	biotin carboxylase activity
I6I51_RS06155	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I51_RS06160	COG0583	DNA-binding transcription factor activity
I6I51_RS06165	COG2217	Heavy metal translocating P-type atpase
I6I51_RS06175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I51_RS06190	COG2234	aminopeptidase activity
I6I51_RS06200	COG3384	dioxygenase
I6I51_RS06210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I51_RS06215	COG2878	Part of a membrane complex involved in electron transport
I6I51_RS06220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I51_RS06245	COG0768	penicillin binding
I6I51_RS06250	COG0742	ribosomal rna small subunit methyltransferase
I6I51_RS06280	COG0653	protein targeting
I6I51_RS06295	COG0582	viral genome integration into host DNA
I6I51_RS06335	COG1570	exodeoxyribonuclease VII activity
I6I51_RS06345	COG1877	trehalose-phosphatase activity
I6I51_RS06350	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I51_RS06355	COG2223	nitrite transmembrane transporter activity
I6I51_RS06400	COG2323	membrane
I6I51_RS06420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I51_RS06440	COG1335	isochorismatase
I6I51_RS06445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I51_RS06545	COG1597	lipid kinase activity
I6I51_RS06550	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I51_RS06565	COG0477	Major facilitator Superfamily
I6I51_RS06615	COG0604	alcohol dehydrogenase
I6I51_RS06615	COG4221	oxidoreductase activity
I6I51_RS06615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I51_RS06615	COG3321	synthase
I6I51_RS06630	COG1695	Transcriptional regulator
I6I51_RS06665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I51_RS06670	COG1773	rubredoxin
I6I51_RS06675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_RS06685	COG0583	DNA-binding transcription factor activity
I6I51_RS06705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I51_RS06710	COG4181	ATPase activity
I6I51_RS06735	COG4771	TonB-dependent receptor
I6I51_RS06755	COG0306	phosphate transporter
I6I51_RS06785	COG2223	nitrite transmembrane transporter activity
I6I51_RS06790	COG2207	Transcriptional regulator
I6I51_RS06795	COG0242	peptide deformylase activity
I6I51_RS06800	COG0477	Major facilitator Superfamily
I6I51_RS06840	COG0456	acetyltransferase
I6I51_RS06845	COG2199	diguanylate cyclase activity
I6I51_RS06845	COG2203	Gaf domain
I6I51_RS06855	COG4681	YaeQ
I6I51_RS06860	COG0523	cobalamin synthesis protein
I6I51_RS06870	COG1607	acyl-coa hydrolase
I6I51_RS06875	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I51_RS06880	COG3293	Transposase
I6I51_RS06890	COG1115	amino acid carrier protein
I6I51_RS06895	COG0786	glutamate:sodium symporter activity
I6I51_RS06910	COG1289	transmembrane transporter activity
I6I51_RS06920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I51_RS06990	COG2832	Protein of unknown function (DUF454)
I6I51_RS07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I51_RS07015	COG0643	Histidine kinase
I6I51_RS07015	COG2198	Histidine kinase
I6I51_RS07015	COG0784	Response regulator, receiver
I6I51_RS07020	COG0840	transmembrane signaling receptor activity
I6I51_RS07090	COG2358	TRAP transporter, solute receptor (TAXI family
I6I51_RS07105	COG0489	protein tyrosine kinase activity
I6I51_RS07130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I51_RS07130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I51_RS07180	COG4716	Myosin-crossreactive antigen
I6I51_RS07210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I51_RS07215	COG2081	HI0933 family
I6I51_RS07230	COG0668	transmembrane transport
I6I51_RS07250	COG0765	amino acid transport
I6I51_RS07255	COG0765	amino acid transport
I6I51_RS07260	COG1126	abc transporter atp-binding protein
I6I51_RS07270	COG0004	ammonium transporteR
I6I51_RS07285	COG0642	Histidine kinase
I6I51_RS07290	COG0745	RESPONSE REGULATOR receiver
I6I51_RS07315	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I51_RS07330	COG0142	geranyltranstransferase activity
I6I51_RS07335	COG2828	Protein conserved in bacteria
I6I51_RS07340	COG1113	amino acid transport
I6I51_RS07350	COG0582	viral genome integration into host DNA
I6I51_RS07390	COG0305	Participates in initiation and elongation during chromosome replication
I6I51_RS07455	COG4372	Transposase
I6I51_RS07495	COG0629	single-stranded DNA binding
I6I51_RS07525	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS07555	COG1113	amino acid transport
I6I51_RS07590	COG0431	NADPH-dependent FMN reductase
I6I51_RS07595	COG0798	PFAM Bile acid sodium symporter
I6I51_RS07605	COG0640	Transcriptional regulator
I6I51_RS07655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I51_RS07670	COG0424	maF-like protein
I6I51_RS07675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I51_RS07680	COG1792	Involved in formation and maintenance of cell shape
I6I51_RS07685	COG1077	Cell shape determining protein MreB Mrl
I6I51_RS07690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I51_RS07700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I51_RS07725	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS07760	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I51_RS07780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I51_RS07805	COG0640	Transcriptional regulator
I6I51_RS07810	COG1136	(ABC) transporter
I6I51_RS07820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_RS07845	COG0582	viral genome integration into host DNA
I6I51_RS07965	COG4373	Mu-like prophage FluMu protein gp28
I6I51_RS07975	COG4383	Mu-like prophage protein gp29
I6I51_RS07980	COG2369	cell adhesion
I6I51_RS08075	COG3561	AntA/AntB antirepressor
I6I51_RS08130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I51_RS08135	COG2814	Major facilitator Superfamily
I6I51_RS08140	COG1566	PFAM secretion protein HlyD family protein
I6I51_RS08145	COG2050	protein possibly involved in aromatic compounds catabolism
I6I51_RS08160	COG1090	epimerase
I6I51_RS08170	COG5001	Diguanylate cyclase
I6I51_RS08170	COG3706	GGDEF domain
I6I51_RS08170	COG4251	negative regulation of phosphorylation
I6I51_RS08170	COG2203	Gaf domain
I6I51_RS08175	COG0420	3'-5' exonuclease activity
I6I51_RS08205	COG0735	belongs to the Fur family
I6I51_RS08210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I51_RS08215	COG2914	Belongs to the UPF0125 (RnfH) family
I6I51_RS08240	COG0121	glutamine amidotransferase
I6I51_RS08255	COG0756	dUTP diphosphatase activity
I6I51_RS08260	COG0210	DNA helicase
I6I51_RS08265	COG2885	chlorophyll binding
I6I51_RS08270	COG0204	Acyl-transferase
I6I51_RS08280	COG0850	regulation of cytokinetic process
I6I51_RS08290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I51_RS08305	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I51_RS08305	COG1674	ftsk spoiiie
I6I51_RS08310	COG0492	ferredoxin-NADP+ reductase activity
I6I51_RS08315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I51_RS08325	COG0456	acetyltransferase
I6I51_RS08335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I51_RS08350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I51_RS08365	COG1981	membrane
I6I51_RS08375	COG1113	amino acid transport
I6I51_RS08380	COG0251	oxidation-reduction process
I6I51_RS08390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I51_RS08420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I51_RS08445	COG2132	Multicopper oxidase
I6I51_RS08455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I51_RS08490	COG1968	undecaprenyl-diphosphatase activity
I6I51_RS08495	COG1214	PFAM Peptidase M22, glycoprotease
I6I51_RS08500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I51_RS08505	COG0494	nUDIX hydrolase
I6I51_RS08540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I51_RS08550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I51_RS08575	COG0693	protein deglycase activity
I6I51_RS08590	COG2814	Major facilitator Superfamily
I6I51_RS08650	COG2199	diguanylate cyclase activity
I6I51_RS08655	COG2885	chlorophyll binding
I6I51_RS08680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I51_RS08685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I51_RS08705	COG0450	alkyl hydroperoxide reductase
I6I51_RS08725	COG0285	dihydrofolate synthase activity
I6I51_RS08795	COG4206	TonB-dependent receptor
I6I51_RS08800	COG2096	Adenosyltransferase
I6I51_RS08820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I51_RS08825	COG2315	Protein conserved in bacteria
I6I51_RS08830	COG1113	amino acid transport
I6I51_RS08835	COG0745	RESPONSE REGULATOR receiver
I6I51_RS08840	COG2205	protein histidine kinase activity
I6I51_RS08850	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS08855	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS08860	COG3223	Belongs to the PsiE family
I6I51_RS08890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I51_RS08910	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS08920	COG0438	transferase activity, transferring glycosyl groups
I6I51_RS08930	COG0463	Glycosyl transferase, family 2
I6I51_RS08950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I51_RS08955	COG5002	protein histidine kinase activity
I6I51_RS08965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I51_RS08975	COG1704	LemA family
I6I51_RS08985	COG1862	Preprotein translocase
I6I51_RS09010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I51_RS09030	COG1426	Protein conserved in bacteria
I6I51_RS09090	COG0440	acetolactate synthase activity
I6I51_RS09095	COG0028	Belongs to the TPP enzyme family
I6I51_RS09120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_RS09125	COG0577	efflux transmembrane transporter activity
I6I51_RS09125	COG1136	(ABC) transporter
I6I51_RS09130	COG1538	Outer membrane efflux protein
I6I51_RS09145	COG2815	serine threonine protein kinase
I6I51_RS09145	COG0515	serine threonine protein kinase
I6I51_RS09160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I51_RS09165	COG1162	GTPase activity
I6I51_RS09190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I51_RS09200	COG3781	membrane
I6I51_RS09205	COG0613	PHP domain protein
I6I51_RS09215	COG2350	Protein conserved in bacteria
I6I51_RS09235	COG1666	GTP binding
I6I51_RS09250	COG1607	acyl-coa hydrolase
I6I51_RS09310	COG1183	phosphatidylcholine synthase activity
I6I51_RS09315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I51_RS09340	COG0039	L-malate dehydrogenase activity
I6I51_RS09350	COG1196	nuclear chromosome segregation
I6I51_RS09350	COG0739	heme binding
I6I51_RS09350	COG0741	lytic transglycosylase activity
I6I51_RS09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I51_RS09360	COG1702	phosphate starvation-inducible protein PhoH
I6I51_RS09365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I51_RS09415	COG1295	ribonuclease BN
I6I51_RS09430	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I51_RS09465	COG0557	exoribonuclease II activity
I6I51_RS09470	COG2720	vancomycin resistance protein
I6I51_RS09475	COG0339	signal peptide processing
I6I51_RS09480	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I51_RS09510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I51_RS09515	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS09525	COG2072	flavoprotein involved in K transport
I6I51_RS09530	COG0203	ribosomal protein L17
I6I51_RS09535	COG0202	RNA polymerase activity
I6I51_RS09550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I51_RS09575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I51_RS09585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I51_RS09590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I51_RS09640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I51_RS09655	COG0088	Forms part of the polypeptide exit tunnel
I6I51_RS09660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I51_RS09680	COG0433	COG0433 Predicted ATPase
I6I51_RS09690	COG1959	2 iron, 2 sulfur cluster binding
I6I51_RS09705	COG1301	dicarboxylic acid transport
I6I51_RS09710	COG1946	Acyl-CoA thioesterase
I6I51_RS09715	COG2937	Belongs to the GPAT DAPAT family
I6I51_RS09740	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS09765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I51_RS09770	COG1040	competence protein
I6I51_RS09775	COG0494	nUDIX hydrolase
I6I51_RS09785	COG0598	Magnesium transport protein CorA
I6I51_RS09795	COG2854	intermembrane phospholipid transfer
I6I51_RS09800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I51_RS09805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I51_RS09810	COG1127	ABC transporter
I6I51_RS09815	COG0513	Belongs to the DEAD box helicase family
I6I51_RS09835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I51_RS09845	COG0408	coproporphyrinogen oxidase activity
I6I51_RS09865	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS09870	COG1910	domain protein
I6I51_RS09890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I51_RS09900	COG0534	Mate efflux family protein
I6I51_RS09910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I51_RS09915	COG0254	rRNA binding
I6I51_RS09920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I51_RS09935	COG2226	methyltransferase
I6I51_RS09945	COG1192	Involved in chromosome partitioning
I6I51_RS09950	COG0628	permease
I6I51_RS09955	COG2032	superoxide dismutase activity
I6I51_RS09965	COG2814	Major facilitator Superfamily
I6I51_RS09990	COG0277	FAD linked oxidase domain protein
I6I51_RS09995	COG3293	Transposase
I6I51_RS10000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I51_RS10005	COG5006	permease, DMT superfamily
I6I51_RS10025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I51_RS10030	COG5380	lipid catabolic process
I6I51_RS10045	COG0335	large ribosomal subunit rRNA binding
I6I51_RS10055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I51_RS10060	COG0228	four-way junction DNA binding
I6I51_RS10095	COG4969	Belongs to the N-Me-Phe pilin family
I6I51_RS10105	COG0194	GDP metabolic process
I6I51_RS10110	COG1758	RNA polymerase activity
I6I51_RS10115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I51_RS10135	COG3307	-O-antigen
I6I51_RS10140	COG3307	-O-antigen
I6I51_RS10160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I51_RS10165	COG1704	LemA family
I6I51_RS10175	COG0493	'glutamate synthase
I6I51_RS10180	COG0069	glutamate synthase activity
I6I51_RS10180	COG0070	glutamate synthase
I6I51_RS10180	COG0067	glutamate synthase
I6I51_RS10230	COG2226	methyltransferase
I6I51_RS10240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I51_RS10245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I51_RS10265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I51_RS10280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I51_RS10300	COG0488	(ABC) transporter
I6I51_RS10305	COG2873	o-acetylhomoserine
I6I51_RS10310	COG4221	oxidoreductase activity
I6I51_RS10340	COG0427	acetyl-CoA hydrolase
I6I51_RS10375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I51_RS10410	COG1278	Cold shock
I6I51_RS10415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I51_RS10440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I51_RS10475	COG0582	viral genome integration into host DNA
I6I51_RS10500	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I51_RS10570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_RS10590	COG0583	DNA-binding transcription factor activity
I6I51_RS10600	COG0629	single-stranded DNA binding
I6I51_RS10640	COG0629	single-stranded DNA binding
I6I51_RS10645	COG2814	Major facilitator Superfamily
I6I51_RS10655	COG0351	phosphomethylpyrimidine kinase
I6I51_RS10655	COG0352	thiamine-phosphate diphosphorylase activity
I6I51_RS10655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I51_RS10685	COG3706	GGDEF domain
I6I51_RS10695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I51_RS10705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I51_RS10710	COG3162	membrane
I6I51_RS10715	COG2205	protein histidine kinase activity
I6I51_RS10715	COG0784	Response regulator, receiver
I6I51_RS10730	COG0431	NADPH-dependent FMN reductase
I6I51_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_RS10750	COG0307	riboflavin synthase, alpha
I6I51_RS10755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I51_RS10760	COG0668	transmembrane transport
I6I51_RS10765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I51_RS10770	COG1519	Transferase
I6I51_RS10775	COG1902	pentaerythritol trinitrate reductase activity
I6I51_RS10805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I51_RS10840	COG0426	domain, Protein
I6I51_RS10840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_RS10845	COG2119	membrane
I6I51_RS10875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I51_RS10885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I51_RS10895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I51_RS10905	COG0189	ligase activity
I6I51_RS10910	COG0386	Belongs to the glutathione peroxidase family
I6I51_RS10940	COG0708	Exodeoxyribonuclease III
I6I51_RS10945	COG1393	Belongs to the ArsC family
I6I51_RS10960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I51_RS11045	COG3150	esterase
I6I51_RS11055	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I51_RS11060	COG2918	glutathione biosynthetic process
I6I51_RS11075	COG2733	membrane
I6I51_RS11080	COG0436	Aminotransferase
I6I51_RS11085	COG0534	Mate efflux family protein
I6I51_RS11155	COG0385	Bile acid
I6I51_RS11160	COG1335	isochorismatase
I6I51_RS11165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I51_RS11185	COG4215	(ABC) transporter
I6I51_RS11190	COG4160	amino acid transport
I6I51_RS11210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I51_RS11215	COG2983	Belongs to the UPF0260 family
I6I51_RS11220	COG5487	UPF0391 membrane protein
I6I51_RS11250	COG2818	Glycosylase
I6I51_RS11255	COG1064	alcohol dehydrogenase
I6I51_RS11260	COG0436	Aminotransferase
I6I51_RS11275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I51_RS11285	COG0484	heat shock protein binding
I6I51_RS11305	COG1309	transcriptional regulator
I6I51_RS11315	COG2233	PERMEase
I6I51_RS11320	COG0583	DNA-binding transcription factor activity
I6I51_RS11350	COG0129	dihydroxy-acid dehydratase activity
I6I51_RS11415	COG0733	neurotransmitter:sodium symporter activity
I6I51_RS11455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I51_RS11460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I51_RS11465	COG2951	lytic endotransglycosylase activity
I6I51_RS11470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I51_RS11485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I51_RS11510	COG0861	Integral membrane protein TerC family
I6I51_RS11520	COG0754	glutathionylspermidine amidase activity
I6I51_RS11530	COG0402	S-adenosylhomocysteine deaminase activity
I6I51_RS11550	COG1230	cation diffusion facilitator family transporter
I6I51_RS11565	COG0583	DNA-binding transcription factor activity
I6I51_RS11580	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I51_RS11585	COG0281	malic enzyme
I6I51_RS11595	COG0706	membrane insertase activity
I6I51_RS11600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I51_RS11615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I51_RS11620	COG0592	DNA-directed DNA polymerase activity
I6I51_RS11630	COG0187	DNA topoisomerase II activity
I6I51_RS11645	COG0488	(ABC) transporter
I6I51_RS11655	COG3293	Transposase
I6I51_RS11710	COG0657	acetylesterase activity
I6I51_RS11720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I51_RS11775	COG1047	Peptidyl-prolyl cis-trans
I6I51_RS11780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I51_RS11785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I51_RS11790	COG0196	riboflavin kinase activity
I6I51_RS11805	COG1309	transcriptional regulator
I6I51_RS11810	COG3293	Transposase
I6I51_RS11815	COG1116	anion transmembrane transporter activity
I6I51_RS11845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I51_RS11850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I51_RS11850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I51_RS11875	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_RS11880	COG0546	phosphoglycolate phosphatase activity
I6I51_RS11885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I51_RS11890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I51_RS11895	COG3307	-O-antigen
I6I51_RS11905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I51_RS11930	COG3293	Transposase
I6I51_RS11940	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I51_RS11945	COG0728	peptidoglycan biosynthetic process
I6I51_RS11975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I51_RS12000	COG0438	transferase activity, transferring glycosyl groups
I6I51_RS12005	COG0438	transferase activity, transferring glycosyl groups
I6I51_RS12010	COG0438	transferase activity, transferring glycosyl groups
I6I51_RS12015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I51_RS12020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I51_RS12030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I51_RS12045	COG1442	glycosyl transferase family 8
I6I51_RS12045	COG1216	Glycosyl transferase, family 2
I6I51_RS12070	COG1216	Glycosyl transferase, family 2
I6I51_RS12075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I51_RS12080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I51_RS12095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I51_RS12105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I51_RS12110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I51_RS12120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I51_RS12125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I51_RS12135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I51_RS12150	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I51_RS12155	COG0583	DNA-binding transcription factor activity
I6I51_RS12160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I51_RS12160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I51_RS12165	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I51_RS12170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_RS12170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I51_RS12170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_RS12175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I51_RS12235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I51_RS12250	COG0531	amino acid
I6I51_RS12255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I51_RS12255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I51_RS12260	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I51_RS12265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_RS12265	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I51_RS12265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_RS12275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I51_RS12295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I51_RS12300	COG0410	ABC transporter
I6I51_RS12325	COG0784	Response regulator, receiver
I6I51_RS12325	COG2205	protein histidine kinase activity
I6I51_RS12340	COG0830	nickel cation binding
I6I51_RS12355	COG0829	nickel cation binding
I6I51_RS12360	COG0831	urea catabolic process
I6I51_RS12370	COG0804	urea catabolic process
I6I51_RS12375	COG3293	Transposase
I6I51_RS12380	COG1278	Cold shock
I6I51_RS12415	COG0402	S-adenosylhomocysteine deaminase activity
I6I51_RS12425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I51_RS12430	COG3550	peptidyl-serine autophosphorylation
I6I51_RS12485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_RS12490	COG0842	Transport permease protein
I6I51_RS12490	COG1129	ABC transporter
I6I51_RS12495	COG0842	Transport permease protein
I6I51_RS12500	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I51_RS12530	COG3756	Protein conserved in bacteria
I6I51_RS12570	COG0271	Belongs to the BolA IbaG family
I6I51_RS12580	COG1192	Involved in chromosome partitioning
I6I51_RS12595	COG0586	Pfam SNARE associated Golgi protein
I6I51_RS12610	COG0519	Catalyzes the synthesis of GMP from XMP
I6I51_RS12610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I51_RS12665	COG0281	malic enzyme
I6I51_RS12680	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS12695	COG2837	iron assimilation
I6I51_RS12705	COG1683	Conserved Protein
I6I51_RS12710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I51_RS12715	COG1121	(ABC) transporter
I6I51_RS12765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I51_RS12800	COG0386	Belongs to the glutathione peroxidase family
I6I51_RS12810	COG0697	spore germination
I6I51_RS12820	COG0758	DNA mediated transformation
I6I51_RS12900	COG3293	Transposase
I6I51_RS12940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I51_RS12950	COG2814	Major facilitator Superfamily
I6I51_RS12970	COG1253	flavin adenine dinucleotide binding
I6I51_RS12975	COG3012	SEC-C Motif Domain Protein
I6I51_RS12980	COG2860	membrane
I6I51_RS12985	COG0477	Major facilitator Superfamily
I6I51_RS12995	COG0318	PFAM AMP-dependent synthetase and ligase
I6I51_RS13010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I51_RS13030	COG0606	chelatase, subunit chli
I6I51_RS13040	COG0347	Belongs to the P(II) protein family
I6I51_RS13045	COG0004	ammonium transporteR
I6I51_RS13055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I51_RS13055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I51_RS13070	COG0586	Pfam SNARE associated Golgi protein
I6I51_RS13090	COG0795	lipopolysaccharide-transporting ATPase activity
I6I51_RS13095	COG0795	lipopolysaccharide-transporting ATPase activity
I6I51_RS13100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I51_RS13105	COG0793	Belongs to the peptidase S41A family
I6I51_RS13120	COG2197	response regulator
I6I51_RS13125	COG1686	Belongs to the peptidase S11 family
I6I51_RS13130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I51_RS13140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I51_RS13145	COG4974	Belongs to the 'phage' integrase family
I6I51_RS13165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I51_RS13170	COG0772	Belongs to the SEDS family
I6I51_RS13175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I51_RS13180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I51_RS13185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I51_RS13195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I51_RS13205	COG1538	Outer membrane efflux protein
I6I51_RS13225	COG3275	phosphorelay sensor kinase activity
I6I51_RS13235	COG0181	hydroxymethylbilane synthase activity
I6I51_RS13255	COG0824	Thioesterase
I6I51_RS13285	COG0546	phosphoglycolate phosphatase activity
I6I51_RS13315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I51_RS13335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I51_RS13340	COG0081	regulation of translation
I6I51_RS13345	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I51_RS13350	COG0222	ribosome binding
I6I51_RS13355	COG0085	RNA polymerase activity
I6I51_RS13360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I51_RS13385	COG2056	Na+-H+ antiporter family
I6I51_RS13390	COG3047	cAMP biosynthetic process
I6I51_RS13400	COG0326	Molecular chaperone. Has ATPase activity
I6I51_RS13430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I51_RS13505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I51_RS13535	COG1289	transmembrane transporter activity
I6I51_RS13550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I51_RS13560	COG0497	DNA recombination
I6I51_RS13570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I51_RS13580	COG0237	dephospho-CoA kinase activity
I6I51_RS13640	COG0195	Participates in both transcription termination and antitermination
I6I51_RS13650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I51_RS13655	COG1320	monovalent cation:proton antiporter activity
I6I51_RS13660	COG2212	antiporter activity
I6I51_RS13665	COG1863	multisubunit Na H antiporter MnhE subunit
I6I51_RS13670	COG0651	ATP synthesis coupled electron transport
I6I51_RS13675	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I51_RS13680	COG2111	Na H antiporter
I6I51_RS13680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I51_RS13685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I51_RS13695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I51_RS13710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I51_RS13740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I51_RS13745	COG1074	ATP-dependent DNA helicase activity
I6I51_RS13750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I51_RS13755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I51_RS13765	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I51_RS13800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I51_RS13810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I51_RS13830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I51_RS13835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I51_RS13840	COG4535	Mg2 and Co2 transporter CorC
I6I51_RS13845	COG0425	Belongs to the sulfur carrier protein TusA family
I6I51_RS13855	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I51_RS13855	COG0644	oxidoreductase
I6I51_RS13865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I51_RS13880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I51_RS13885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I51_RS13895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I51_RS13895	COG0493	'glutamate synthase
I6I51_RS13910	COG2226	methyltransferase
I6I51_RS13925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I51_RS13950	COG0751	glycine-tRNA ligase activity
I6I51_RS13975	COG1983	PspC domain protein
I6I51_RS14000	COG0318	PFAM AMP-dependent synthetase and ligase
I6I51_RS14005	COG1530	ribonuclease E activity
I6I51_RS14010	COG0564	pseudouridine synthase activity
I6I51_RS14025	COG0583	DNA-binding transcription factor activity
I6I51_RS14055	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS14060	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6I51_RS14070	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS14085	COG1960	acyl-CoA dehydrogenase activity
I6I51_RS14100	COG1280	lysine exporter protein (LysE YggA)
I6I51_RS14135	COG0583	DNA-binding transcription factor activity
I6I51_RS14145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I51_RS14160	COG0473	3-isopropylmalate dehydrogenase activity
I6I51_RS14220	COG1560	Kdo2-lipid A biosynthetic process
I6I51_RS14225	COG0488	(ABC) transporter
I6I51_RS14230	COG2900	Belongs to the SlyX family
I6I51_RS14275	COG0210	DNA helicase
I6I51_RS14300	COG4651	solute:proton antiporter activity
I6I51_RS14300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I51_RS14325	COG0788	formyltetrahydrofolate deformylase activity
I6I51_RS14430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I51_RS14430	COG2813	Specifically methylates the guanine in position
I6I51_RS14440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I51_RS14455	COG4774	siderophore transport
I6I51_RS14460	COG4771	TonB-dependent receptor
I6I51_RS14470	COG0740	serine-type endopeptidase activity
I6I51_RS14490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I51_RS14490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I51_RS14495	COG1917	Cupin 2, conserved barrel domain protein
I6I51_RS14495	COG2207	Transcriptional regulator
I6I51_RS14505	COG2318	DinB family
I6I51_RS14515	COG0280	phosphate acetyltransferase
I6I51_RS14515	COG0857	belongs to the CobB CobQ family
I6I51_RS14520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I51_RS14530	COG2267	carboxylic ester hydrolase activity
I6I51_RS14545	COG0793	Belongs to the peptidase S41A family
I6I51_RS14555	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I51_RS14570	COG0084	hydrolase, TatD family'
I6I51_RS14580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I51_RS14595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I51_RS14605	COG2814	Major facilitator Superfamily
I6I51_RS14630	COG0004	ammonium transporteR
I6I51_RS14645	COG3622	Belongs to the hyi family
I6I51_RS14650	COG2084	Dehydrogenase
I6I51_RS14655	COG1024	Enoyl-CoA hydratase
I6I51_RS14660	COG5002	protein histidine kinase activity
I6I51_RS14660	COG2205	protein histidine kinase activity
I6I51_RS14660	COG0784	Response regulator, receiver
I6I51_RS14665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I51_RS14680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I51_RS14690	COG3956	TIGRFAM MazG family protein
I6I51_RS14695	COG1555	photosystem II stabilization
I6I51_RS14700	COG0617	tRNA 3'-terminal CCA addition
I6I51_RS14705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I51_RS14715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I51_RS14720	COG1660	Displays ATPase and GTPase activities
I6I51_RS14730	COG3028	Belongs to the UPF0307 family
I6I51_RS14735	COG0318	PFAM AMP-dependent synthetase and ligase
I6I51_RS14755	COG0625	glutathione transferase activity
I6I51_RS14765	COG1238	metal cluster binding
I6I51_RS14810	COG0072	phenylalanine-tRNA ligase activity
I6I51_RS14835	COG0248	Ppx GppA phosphatase
I6I51_RS14845	COG0037	tRNA processing
I6I51_RS14865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I51_RS14865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I51_RS14910	COG1764	response to oxidative stress
I6I51_RS14915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I51_RS14925	COG2208	phosphoserine phosphatase activity
I6I51_RS14930	COG2853	Lipoprotein
I6I51_RS14985	COG2969	positive regulation of protein catabolic process
I6I51_RS14990	COG0625	glutathione transferase activity
I6I51_RS15000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I51_RS15005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I51_RS15015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I51_RS15020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I51_RS15025	COG4372	Transposase
I6I51_RS15060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I51_RS15070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I51_RS15075	COG1408	metallophosphoesterase
I6I51_RS15085	COG0477	Major facilitator Superfamily
I6I51_RS15090	COG1272	protein, Hemolysin III
I6I51_RS15110	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I51_RS15110	COG1024	Enoyl-CoA hydratase
I6I51_RS15115	COG0183	Belongs to the thiolase family
I6I51_RS15120	COG2207	Transcriptional regulator
I6I51_RS15125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I51_RS15140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_RS15160	COG0183	Belongs to the thiolase family
I6I51_RS15185	COG0833	amino acid
I6I51_RS15190	COG2813	Specifically methylates the guanine in position
I6I51_RS15195	COG2233	PERMEase
I6I51_RS15200	COG1217	gtp-binding protein TYPA
I6I51_RS15205	COG1970	mechanosensitive ion channel activity
I6I51_RS15220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I51_RS15230	COG3659	wide pore channel activity
I6I51_RS15235	COG1902	pentaerythritol trinitrate reductase activity
I6I51_RS15325	COG0346	lactoylglutathione lyase activity
I6I51_RS15330	COG0564	pseudouridine synthase activity
I6I51_RS15350	COG3189	MarR family transcriptional regulator
I6I51_RS15355	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I51_RS15365	COG3422	double-strand break repair
I6I51_RS15395	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS15405	COG2801	Transposase and inactivated derivatives
I6I51_RS15415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I51_RS15435	COG0730	response to heat
I6I51_RS15445	COG1196	nuclear chromosome segregation
I6I51_RS15450	COG3115	cell septum assembly
I6I51_RS15455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I51_RS15460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I51_RS15465	COG4774	siderophore transport
I6I51_RS15485	COG2193	ferroxidase activity
I6I51_RS15490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I51_RS15495	COG0596	Alpha beta hydrolase
I6I51_RS15495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I51_RS15495	COG2226	methyltransferase
I6I51_RS15510	COG4106	trans-aconitate 2-methyltransferase activity
I6I51_RS15555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I51_RS15560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I51_RS15570	COG0009	L-threonylcarbamoyladenylate synthase
I6I51_RS15575	COG3101	peptidyl-lysine hydroxylation
I6I51_RS15580	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I51_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_RS15605	COG1652	LysM domain
I6I51_RS15610	COG1802	Transcriptional regulator
I6I51_RS15615	COG0439	Biotin carboxylase
I6I51_RS15645	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS15675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I51_RS15690	COG0745	RESPONSE REGULATOR receiver
I6I51_RS15695	COG2205	protein histidine kinase activity
I6I51_RS15705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I51_RS15725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I51_RS15740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I51_RS15750	COG0713	ATP synthesis coupled electron transport
I6I51_RS15755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I51_RS15760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I51_RS15775	COG1278	Cold shock
I6I51_RS15780	COG1278	Cold shock
I6I51_RS15785	COG0583	DNA-binding transcription factor activity
I6I51_RS15815	COG0525	valine-tRNA ligase activity
I6I51_RS15825	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_RS15840	COG0393	Putative heavy-metal-binding
I6I51_RS15845	COG1538	Outer membrane efflux protein
I6I51_RS15855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_RS15860	COG0671	phosphoesterase, PA-phosphatase related
I6I51_RS15880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I51_RS15895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I51_RS15905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I51_RS15910	COG1648	precorrin-2 dehydrogenase activity
I6I51_RS15910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I51_RS15915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I51_RS15935	COG0531	amino acid
I6I51_RS15950	COG0321	lipoyl(octanoyl) transferase activity
I6I51_RS15955	COG2921	Belongs to the UPF0250 family
I6I51_RS15990	COG0586	Pfam SNARE associated Golgi protein
I6I51_RS16015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I51_RS16025	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_RS16050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I51_RS16055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I51_RS16085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I51_RS16100	COG0358	DNA primase activity
I6I51_RS16110	COG0564	pseudouridine synthase activity
I6I51_RS16135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I51_RS16160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I51_RS16160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I51_RS16180	COG2072	flavoprotein involved in K transport
I6I51_RS16190	COG2009	succinate dehydrogenase
I6I51_RS16195	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I51_RS16200	COG1053	succinate dehydrogenase
I6I51_RS16205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I51_RS16220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I51_RS16230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I51_RS16240	COG0726	polysaccharide deacetylase
I6I51_RS16240	COG1649	PFAM Uncharacterised BCR, COG1649
I6I51_RS16245	COG1215	transferase activity, transferring glycosyl groups
I6I51_RS16255	COG0726	polysaccharide deacetylase
I6I51_RS16255	COG1649	PFAM Uncharacterised BCR, COG1649
I6I51_RS16265	COG2268	Band 7 protein
I6I51_RS16280	COG2354	Protein conserved in bacteria
I6I51_RS16285	COG2321	neutral zinc metallopeptidase
I6I51_RS16305	COG3695	enzyme binding
I6I51_RS16330	COG0110	maltose O-acetyltransferase activity
I6I51_RS16340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I51_RS16345	COG0505	Belongs to the CarA family
I6I51_RS16370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I51_RS16375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I51_RS16415	COG2851	Citrate transporter
I6I51_RS16420	COG1253	flavin adenine dinucleotide binding
I6I51_RS16450	COG2239	Acts as a magnesium transporter
I6I51_RS16465	COG0501	Belongs to the peptidase M48B family
I6I51_RS16470	COG0741	lytic transglycosylase activity
I6I51_RS16475	COG0037	tRNA processing
I6I51_RS16485	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I51_RS16490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I51_RS16515	COG5006	permease, DMT superfamily
I6I51_RS16525	COG1309	transcriptional regulator
I6I51_RS16540	COG1741	Belongs to the pirin family
I6I51_RS16560	COG3739	integral membrane protein
I6I51_RS16585	COG0302	gtp cyclohydrolase
I6I51_RS16595	COG0300	oxidoreductase activity
I6I51_RS16615	COG0134	indole-3-glycerol-phosphate synthase activity
I6I51_RS16620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I51_RS16625	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I51_RS16630	COG0174	glutamine synthetase
I6I51_RS16640	COG3161	chorismate lyase activity
I6I51_RS16645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I51_RS16685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I51_RS16690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I51_RS16695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I51_RS16700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I51_RS16715	COG1115	amino acid carrier protein
I6I51_RS16720	COG1113	amino acid transport
I6I51_RS16730	COG0019	diaminopimelate decarboxylase activity
I6I51_RS16740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I51_RS16750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I51_RS16755	COG1522	sequence-specific DNA binding
I6I51_RS16760	COG1280	lysine exporter protein (LysE YggA)
I6I51_RS16825	COG2963	transposase activity
I6I51_RS16830	COG1979	alcohol dehydrogenase
I6I51_RS16845	COG1012	belongs to the aldehyde dehydrogenase family
I6I51_RS16850	COG1902	pentaerythritol trinitrate reductase activity
I6I51_RS16860	COG1309	transcriptional regulator
I6I51_RS16865	COG2130	NADP-dependent
I6I51_RS16875	COG1764	response to oxidative stress
I6I51_RS16880	COG1846	Transcriptional regulator
I6I51_RS16895	COG3842	ATPase activity
I6I51_RS16900	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I51_RS16915	COG3335	DDE superfamily endonuclease
I6I51_RS16945	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I51_RS16965	COG0604	alcohol dehydrogenase
I6I51_RS16985	COG1063	alcohol dehydrogenase
I6I51_RS17000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I51_RS17085	COG4372	Transposase
I6I51_RS17095	COG2963	transposase activity
I6I51_RS17110	COG1475	DNA binding
I6I51_RS17115	COG1192	Involved in chromosome partitioning
I6I51_RS17170	COG4456	Virulence-associated protein
I6I51_RS17225	COG3077	Addiction module antitoxin, RelB DinJ family
I6I51_RS17240	COG3128	pkhd-type hydroxylase