locus-tag	class	description
I6G67_RS00030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G67_RS00035	COG1280	lysine exporter protein (LysE YggA)
I6G67_RS00110	COG2733	membrane
I6G67_RS00125	COG2918	glutathione biosynthetic process
I6G67_RS00130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G67_RS00140	COG3150	esterase
I6G67_RS00230	COG3706	GGDEF domain
I6G67_RS00235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G67_RS00255	COG1393	Belongs to the ArsC family
I6G67_RS00260	COG0708	Exodeoxyribonuclease III
I6G67_RS00270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G67_RS00285	COG1846	Transcriptional regulator
I6G67_RS00290	COG0386	Belongs to the glutathione peroxidase family
I6G67_RS00295	COG0189	ligase activity
I6G67_RS00305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G67_RS00315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G67_RS00325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G67_RS00355	COG2119	membrane
I6G67_RS00360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G67_RS00360	COG0426	domain, Protein
I6G67_RS00385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G67_RS00410	COG1902	pentaerythritol trinitrate reductase activity
I6G67_RS00415	COG1519	Transferase
I6G67_RS00420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G67_RS00425	COG0668	transmembrane transport
I6G67_RS00430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G67_RS00435	COG0307	riboflavin synthase, alpha
I6G67_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS00455	COG0431	NADPH-dependent FMN reductase
I6G67_RS00475	COG2205	protein histidine kinase activity
I6G67_RS00475	COG0784	Response regulator, receiver
I6G67_RS00480	COG3162	membrane
I6G67_RS00495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G67_RS00505	COG3706	GGDEF domain
I6G67_RS00530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G67_RS00530	COG0352	thiamine-phosphate diphosphorylase activity
I6G67_RS00530	COG0351	phosphomethylpyrimidine kinase
I6G67_RS00540	COG2814	Major facilitator Superfamily
I6G67_RS00545	COG0629	single-stranded DNA binding
I6G67_RS00605	COG0583	DNA-binding transcription factor activity
I6G67_RS00610	COG1301	dicarboxylic acid transport
I6G67_RS00625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G67_RS00635	COG0583	DNA-binding transcription factor activity
I6G67_RS00640	COG1335	isochorismatase
I6G67_RS00650	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6G67_RS00675	COG1570	exodeoxyribonuclease VII activity
I6G67_RS00765	COG0305	Participates in initiation and elongation during chromosome replication
I6G67_RS00795	COG0582	viral genome integration into host DNA
I6G67_RS00825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G67_RS00850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G67_RS00855	COG1278	Cold shock
I6G67_RS00890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G67_RS00925	COG0427	acetyl-CoA hydrolase
I6G67_RS00950	COG4221	oxidoreductase activity
I6G67_RS00960	COG0488	(ABC) transporter
I6G67_RS00980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G67_RS01045	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G67_RS01065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G67_RS01070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G67_RS01080	COG2226	methyltransferase
I6G67_RS01130	COG0067	glutamate synthase
I6G67_RS01130	COG0069	glutamate synthase activity
I6G67_RS01130	COG0070	glutamate synthase
I6G67_RS01135	COG0493	'glutamate synthase
I6G67_RS01145	COG1704	LemA family
I6G67_RS01150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G67_RS01210	COG4969	Belongs to the N-Me-Phe pilin family
I6G67_RS01245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G67_RS01250	COG1758	RNA polymerase activity
I6G67_RS01255	COG0194	GDP metabolic process
I6G67_RS01260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G67_RS01300	COG0228	four-way junction DNA binding
I6G67_RS01305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G67_RS01315	COG0335	large ribosomal subunit rRNA binding
I6G67_RS01330	COG5380	lipid catabolic process
I6G67_RS01335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G67_RS01355	COG5006	permease, DMT superfamily
I6G67_RS01360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G67_RS01365	COG0277	FAD linked oxidase domain protein
I6G67_RS01400	COG2814	Major facilitator Superfamily
I6G67_RS01405	COG1289	transmembrane transporter activity
I6G67_RS01410	COG2032	superoxide dismutase activity
I6G67_RS01415	COG0628	permease
I6G67_RS01420	COG1192	Involved in chromosome partitioning
I6G67_RS01430	COG2226	methyltransferase
I6G67_RS01445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G67_RS01450	COG0254	rRNA binding
I6G67_RS01455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G67_RS01465	COG0534	Mate efflux family protein
I6G67_RS01475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G67_RS01495	COG1910	domain protein
I6G67_RS01500	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS01520	COG0408	coproporphyrinogen oxidase activity
I6G67_RS01525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G67_RS01535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G67_RS01545	COG0513	Belongs to the DEAD box helicase family
I6G67_RS01550	COG1127	ABC transporter
I6G67_RS01555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G67_RS01560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G67_RS01565	COG2854	intermembrane phospholipid transfer
I6G67_RS01575	COG0598	Magnesium transport protein CorA
I6G67_RS01585	COG0494	nUDIX hydrolase
I6G67_RS01590	COG1040	competence protein
I6G67_RS01595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G67_RS01615	COG2801	Transposase and inactivated derivatives
I6G67_RS01625	COG2937	Belongs to the GPAT DAPAT family
I6G67_RS01630	COG1946	Acyl-CoA thioesterase
I6G67_RS01635	COG1301	dicarboxylic acid transport
I6G67_RS01650	COG1959	2 iron, 2 sulfur cluster binding
I6G67_RS01660	COG0433	COG0433 Predicted ATPase
I6G67_RS01680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G67_RS01685	COG0088	Forms part of the polypeptide exit tunnel
I6G67_RS01700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G67_RS01750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G67_RS01755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G67_RS01765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G67_RS01790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G67_RS01805	COG0202	RNA polymerase activity
I6G67_RS01810	COG0203	ribosomal protein L17
I6G67_RS01815	COG2072	flavoprotein involved in K transport
I6G67_RS01825	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS01830	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G67_RS01865	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G67_RS01870	COG0339	signal peptide processing
I6G67_RS01875	COG2720	vancomycin resistance protein
I6G67_RS01880	COG0557	exoribonuclease II activity
I6G67_RS01910	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G67_RS01925	COG1295	ribonuclease BN
I6G67_RS01965	COG4773	Receptor
I6G67_RS01975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G67_RS01980	COG1702	phosphate starvation-inducible protein PhoH
I6G67_RS01985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G67_RS01990	COG1196	nuclear chromosome segregation
I6G67_RS01990	COG0739	heme binding
I6G67_RS01990	COG0741	lytic transglycosylase activity
I6G67_RS02000	COG0039	L-malate dehydrogenase activity
I6G67_RS02025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G67_RS02030	COG1183	phosphatidylcholine synthase activity
I6G67_RS02090	COG1607	acyl-coa hydrolase
I6G67_RS02105	COG1666	GTP binding
I6G67_RS02125	COG2350	Protein conserved in bacteria
I6G67_RS02135	COG0613	PHP domain protein
I6G67_RS02140	COG3781	membrane
I6G67_RS02150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G67_RS02175	COG1162	GTPase activity
I6G67_RS02180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G67_RS02195	COG1538	Outer membrane efflux protein
I6G67_RS02200	COG1136	(ABC) transporter
I6G67_RS02200	COG0577	efflux transmembrane transporter activity
I6G67_RS02205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G67_RS02230	COG0028	Belongs to the TPP enzyme family
I6G67_RS02235	COG0440	acetolactate synthase activity
I6G67_RS02295	COG1426	Protein conserved in bacteria
I6G67_RS02315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G67_RS02340	COG1862	Preprotein translocase
I6G67_RS02350	COG1704	LemA family
I6G67_RS02360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G67_RS02370	COG5002	protein histidine kinase activity
I6G67_RS02375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G67_RS02385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G67_RS02395	COG0438	transferase activity, transferring glycosyl groups
I6G67_RS02425	COG3306	glycosyltransferase involved in LPS biosynthesis
I6G67_RS02445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G67_RS02475	COG3223	Belongs to the PsiE family
I6G67_RS02480	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS02485	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS02495	COG2205	protein histidine kinase activity
I6G67_RS02500	COG0745	RESPONSE REGULATOR receiver
I6G67_RS02505	COG1113	amino acid transport
I6G67_RS02510	COG2315	Protein conserved in bacteria
I6G67_RS02515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6G67_RS02535	COG2096	Adenosyltransferase
I6G67_RS02540	COG4206	TonB-dependent receptor
I6G67_RS02590	COG0285	dihydrofolate synthase activity
I6G67_RS02610	COG0450	alkyl hydroperoxide reductase
I6G67_RS02630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G67_RS02635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G67_RS02665	COG2199	diguanylate cyclase activity
I6G67_RS02725	COG2969	positive regulation of protein catabolic process
I6G67_RS02730	COG0625	glutathione transferase activity
I6G67_RS02740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G67_RS02745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G67_RS02750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G67_RS02755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G67_RS02760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G67_RS02785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G67_RS02795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G67_RS02800	COG1408	metallophosphoesterase
I6G67_RS02815	COG0477	Major facilitator Superfamily
I6G67_RS02820	COG1272	protein, Hemolysin III
I6G67_RS02840	COG1024	Enoyl-CoA hydratase
I6G67_RS02840	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G67_RS02845	COG0183	Belongs to the thiolase family
I6G67_RS02850	COG2207	Transcriptional regulator
I6G67_RS02855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G67_RS02870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_RS02900	COG0183	Belongs to the thiolase family
I6G67_RS02915	COG0833	amino acid
I6G67_RS02920	COG2813	Specifically methylates the guanine in position
I6G67_RS02925	COG2233	PERMEase
I6G67_RS02930	COG1217	gtp-binding protein TYPA
I6G67_RS02935	COG1970	mechanosensitive ion channel activity
I6G67_RS02945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G67_RS02955	COG3659	wide pore channel activity
I6G67_RS02960	COG1902	pentaerythritol trinitrate reductase activity
I6G67_RS02990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G67_RS03035	COG0346	lactoylglutathione lyase activity
I6G67_RS03040	COG0564	pseudouridine synthase activity
I6G67_RS03060	COG3189	MarR family transcriptional regulator
I6G67_RS03065	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G67_RS03075	COG3422	double-strand break repair
I6G67_RS03095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G67_RS03100	COG0488	(ABC) transporter
I6G67_RS03120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G67_RS03140	COG0730	response to heat
I6G67_RS03150	COG1196	nuclear chromosome segregation
I6G67_RS03155	COG3115	cell septum assembly
I6G67_RS03165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G67_RS03190	COG4372	Transposase
I6G67_RS03240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G67_RS03245	COG4774	siderophore transport
I6G67_RS03265	COG2193	ferroxidase activity
I6G67_RS03270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G67_RS03275	COG0596	Alpha beta hydrolase
I6G67_RS03275	COG2226	methyltransferase
I6G67_RS03275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_RS03290	COG4106	trans-aconitate 2-methyltransferase activity
I6G67_RS03370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G67_RS03375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G67_RS03385	COG0009	L-threonylcarbamoyladenylate synthase
I6G67_RS03390	COG3101	peptidyl-lysine hydroxylation
I6G67_RS03395	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G67_RS03410	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS03420	COG1652	LysM domain
I6G67_RS03425	COG1802	Transcriptional regulator
I6G67_RS03430	COG0439	Biotin carboxylase
I6G67_RS03475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G67_RS03495	COG0745	RESPONSE REGULATOR receiver
I6G67_RS03500	COG2205	protein histidine kinase activity
I6G67_RS03510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G67_RS03530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6G67_RS03545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G67_RS03555	COG0713	ATP synthesis coupled electron transport
I6G67_RS03560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G67_RS03565	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G67_RS03580	COG1278	Cold shock
I6G67_RS03590	COG0583	DNA-binding transcription factor activity
I6G67_RS03620	COG0525	valine-tRNA ligase activity
I6G67_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS03645	COG0393	Putative heavy-metal-binding
I6G67_RS03650	COG1538	Outer membrane efflux protein
I6G67_RS03660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G67_RS03665	COG0671	phosphoesterase, PA-phosphatase related
I6G67_RS03685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G67_RS03710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G67_RS03720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G67_RS03725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G67_RS03725	COG1648	precorrin-2 dehydrogenase activity
I6G67_RS03730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G67_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS03750	COG0531	amino acid
I6G67_RS03765	COG0321	lipoyl(octanoyl) transferase activity
I6G67_RS03770	COG2921	Belongs to the UPF0250 family
I6G67_RS03790	COG1280	lysine exporter protein (LysE YggA)
I6G67_RS03805	COG0586	Pfam SNARE associated Golgi protein
I6G67_RS03855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G67_RS03860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G67_RS03890	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G67_RS03905	COG0358	DNA primase activity
I6G67_RS03915	COG0564	pseudouridine synthase activity
I6G67_RS03940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G67_RS03970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G67_RS03970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G67_RS03985	COG0300	oxidoreductase activity
I6G67_RS03990	COG2072	flavoprotein involved in K transport
I6G67_RS04000	COG2009	succinate dehydrogenase
I6G67_RS04005	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G67_RS04010	COG1053	succinate dehydrogenase
I6G67_RS04015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G67_RS04030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G67_RS04040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G67_RS04050	COG2268	Band 7 protein
I6G67_RS04055	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G67_RS04065	COG2354	Protein conserved in bacteria
I6G67_RS04070	COG2321	neutral zinc metallopeptidase
I6G67_RS04085	COG3695	enzyme binding
I6G67_RS04105	COG0110	maltose O-acetyltransferase activity
I6G67_RS04115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G67_RS04120	COG0505	Belongs to the CarA family
I6G67_RS04145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G67_RS04150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G67_RS04190	COG2851	Citrate transporter
I6G67_RS04195	COG1253	flavin adenine dinucleotide binding
I6G67_RS04225	COG2239	Acts as a magnesium transporter
I6G67_RS04240	COG0501	Belongs to the peptidase M48B family
I6G67_RS04245	COG0741	lytic transglycosylase activity
I6G67_RS04250	COG0037	tRNA processing
I6G67_RS04260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G67_RS04265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G67_RS04295	COG1309	transcriptional regulator
I6G67_RS04310	COG1741	Belongs to the pirin family
I6G67_RS04330	COG3739	integral membrane protein
I6G67_RS04345	COG3706	GGDEF domain
I6G67_RS04355	COG0302	gtp cyclohydrolase
I6G67_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS04370	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_RS04380	COG2909	trisaccharide binding
I6G67_RS04390	COG0134	indole-3-glycerol-phosphate synthase activity
I6G67_RS04395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G67_RS04400	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G67_RS04405	COG0174	glutamine synthetase
I6G67_RS04415	COG3161	chorismate lyase activity
I6G67_RS04420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G67_RS04445	COG3550	peptidyl-serine autophosphorylation
I6G67_RS04475	COG0471	metal ion transport
I6G67_RS04515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G67_RS04565	COG2217	Heavy metal translocating P-type atpase
I6G67_RS04570	COG3174	membrane
I6G67_RS04575	COG2205	protein histidine kinase activity
I6G67_RS04590	COG2132	Multicopper oxidase
I6G67_RS04610	COG2433	Pfam Transposase IS66
I6G67_RS04675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G67_RS04690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G67_RS04695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G67_RS04700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G67_RS04720	COG1115	amino acid carrier protein
I6G67_RS04725	COG1113	amino acid transport
I6G67_RS04735	COG0019	diaminopimelate decarboxylase activity
I6G67_RS04745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6G67_RS04755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G67_RS04760	COG1522	sequence-specific DNA binding
I6G67_RS04805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G67_RS04820	COG2175	clavaminate synthase activity
I6G67_RS04840	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G67_RS04885	COG2951	lytic endotransglycosylase activity
I6G67_RS04900	COG0842	Transport permease protein
I6G67_RS04905	COG1131	(ABC) transporter
I6G67_RS04970	COG3723	Recombinational DNA repair protein, rece pathway
I6G67_RS05175	COG3646	Phage regulatory protein
I6G67_RS05195	COG2357	RelA SpoT domain protein
I6G67_RS05265	COG2365	Tyrosine phosphatase family
I6G67_RS05285	COG0303	'Molybdopterin
I6G67_RS05290	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G67_RS05290	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G67_RS05295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G67_RS05300	COG0243	molybdopterin cofactor binding
I6G67_RS05305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G67_RS05315	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G67_RS05320	COG4149	molybdate abc transporter
I6G67_RS05360	COG2169	Transcriptional regulator
I6G67_RS05365	COG0235	Class ii aldolase
I6G67_RS05370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G67_RS05375	COG0697	spore germination
I6G67_RS05380	COG0475	glutathione-regulated potassium exporter activity
I6G67_RS05380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G67_RS05385	COG3706	GGDEF domain
I6G67_RS05430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G67_RS05455	COG3634	alkyl hydroperoxide reductase activity
I6G67_RS05460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G67_RS05465	COG0826	peptidase U32
I6G67_RS05495	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_RS05555	COG1720	tRNA m6t6A37 methyltransferase activity
I6G67_RS05580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G67_RS05595	COG0642	Histidine kinase
I6G67_RS05605	COG0494	nUDIX hydrolase
I6G67_RS05615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G67_RS05620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G67_RS05625	COG3139	Protein of unknown function (DUF1315)
I6G67_RS05635	COG1301	dicarboxylic acid transport
I6G67_RS05640	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS05645	COG0693	protein deglycase activity
I6G67_RS05655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G67_RS05660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G67_RS05690	COG0415	Belongs to the DNA photolyase family
I6G67_RS05700	COG2252	PERMEase
I6G67_RS05705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G67_RS05715	COG3038	cytochrome b561
I6G67_RS05730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G67_RS05740	COG0527	aspartate kinase activity
I6G67_RS05750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G67_RS05765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G67_RS05770	COG1522	sequence-specific DNA binding
I6G67_RS05785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G67_RS05800	COG0667	Aldo Keto reductase
I6G67_RS05810	COG1765	OsmC-like protein
I6G67_RS05835	COG0540	Belongs to the ATCase OTCase family
I6G67_RS05855	COG2031	fatty acid transporter
I6G67_RS05860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_RS05875	COG4770	biotin carboxylase activity
I6G67_RS05885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G67_RS05890	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS05895	COG1309	transcriptional regulator
I6G67_RS05900	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_RS05930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G67_RS05940	COG0659	secondary active sulfate transmembrane transporter activity
I6G67_RS05945	COG0625	glutathione transferase activity
I6G67_RS05950	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G67_RS05975	COG2363	Small membrane protein
I6G67_RS05990	COG1278	Cold shock
I6G67_RS05995	COG0513	Belongs to the DEAD box helicase family
I6G67_RS06005	COG0778	Nitroreductase
I6G67_RS06060	COG4783	chaperone-mediated protein folding
I6G67_RS06065	COG1610	YqeY-like protein
I6G67_RS06095	COG2815	serine threonine protein kinase
I6G67_RS06095	COG0515	serine threonine protein kinase
I6G67_RS06135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G67_RS06145	COG1643	Atp-dependent helicase
I6G67_RS06165	COG1116	anion transmembrane transporter activity
I6G67_RS06165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_RS06175	COG2223	nitrite transmembrane transporter activity
I6G67_RS06180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_RS06185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_RS06190	COG0243	molybdopterin cofactor binding
I6G67_RS06200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G67_RS06235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6G67_RS06240	COG0406	alpha-ribazole phosphatase activity
I6G67_RS06250	COG0517	IMP dehydrogenase activity
I6G67_RS06250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G67_RS06255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G67_RS06265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G67_RS06270	COG1137	ATPase activity
I6G67_RS06290	COG4122	O-methyltransferase activity
I6G67_RS06300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G67_RS06340	COG2011	ABC-type metal ion transport system permease component
I6G67_RS06345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G67_RS06380	COG0138	bifunctional purine biosynthesis protein purh
I6G67_RS06385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6G67_RS06415	COG0445	tRNA wobble uridine modification
I6G67_RS06440	COG2308	Evidence 4 Homologs of previously reported genes of
I6G67_RS06450	COG1305	Transglutaminase-like
I6G67_RS06470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G67_RS06475	COG0305	Participates in initiation and elongation during chromosome replication
I6G67_RS06490	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G67_RS06510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G67_RS06515	COG1845	cytochrome c oxidase, subunit III
I6G67_RS06520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G67_RS06525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G67_RS06555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G67_RS06570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G67_RS06575	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G67_RS06580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G67_RS06585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_RS06615	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS06620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G67_RS06635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G67_RS06660	COG0729	surface antigen
I6G67_RS06705	COG4773	Receptor
I6G67_RS06710	COG0786	glutamate:sodium symporter activity
I6G67_RS06720	COG1113	amino acid transport
I6G67_RS06745	COG0024	Methionine aminopeptidase
I6G67_RS06750	COG0583	DNA-binding transcription factor activity
I6G67_RS06755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G67_RS06770	COG3852	Histidine kinase
I6G67_RS06790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G67_RS06795	COG0575	Belongs to the CDS family
I6G67_RS06810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G67_RS06830	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G67_RS06855	COG2137	regulation of response to DNA damage stimulus
I6G67_RS06860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G67_RS06865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G67_RS06870	COG1011	Hydrolase
I6G67_RS06910	COG0702	epimerase
I6G67_RS06915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G67_RS06925	COG2267	carboxylic ester hydrolase activity
I6G67_RS06935	COG1902	pentaerythritol trinitrate reductase activity
I6G67_RS06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G67_RS06950	COG2814	Major facilitator Superfamily
I6G67_RS06960	COG0583	DNA-binding transcription factor activity
I6G67_RS06980	COG0148	phosphopyruvate hydratase activity
I6G67_RS06995	COG0772	Belongs to the SEDS family
I6G67_RS07010	COG0579	oxidoreductase
I6G67_RS07020	COG1012	belongs to the aldehyde dehydrogenase family
I6G67_RS07025	COG1309	transcriptional regulator
I6G67_RS07030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G67_RS07045	COG4890	Cyd operon protein YbgT
I6G67_RS07050	COG1294	oxidase, subunit
I6G67_RS07065	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G67_RS07075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G67_RS07095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G67_RS07100	COG0569	domain protein
I6G67_RS07110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G67_RS07115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G67_RS07125	COG3706	GGDEF domain
I6G67_RS07140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G67_RS07145	COG0542	response to heat
I6G67_RS07175	COG0372	Belongs to the citrate synthase family
I6G67_RS07185	COG2819	hydrolase of the alpha beta superfamily
I6G67_RS07190	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_RS07210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G67_RS07210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G67_RS07215	COG1254	Belongs to the acylphosphatase family
I6G67_RS07220	COG1047	Peptidyl-prolyl cis-trans
I6G67_RS07225	COG1252	NADH dehydrogenase
I6G67_RS07230	COG1686	Belongs to the peptidase S11 family
I6G67_RS07240	COG2351	hydroxyisourate hydrolase activity
I6G67_RS07295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G67_RS07300	COG1823	symporter activity
I6G67_RS07310	COG0612	Peptidase, M16
I6G67_RS07345	COG0352	thiamine-phosphate diphosphorylase activity
I6G67_RS07390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G67_RS07395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G67_RS07410	COG2353	YceI-like domain
I6G67_RS07415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G67_RS07415	COG0519	Catalyzes the synthesis of GMP from XMP
I6G67_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS07435	COG4302	ethanolamine ammonia-lyase activity
I6G67_RS07440	COG4303	Ethanolamine ammonia lyase large subunit
I6G67_RS07445	COG0531	amino acid
I6G67_RS07465	COG1454	alcohol dehydrogenase
I6G67_RS07475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G67_RS07480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G67_RS07485	COG2814	Major facilitator Superfamily
I6G67_RS07490	COG2707	UPF0756 membrane protein
I6G67_RS07515	COG0802	atpase or kinase
I6G67_RS07520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G67_RS07530	COG1923	regulation of RNA biosynthetic process
I6G67_RS07535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G67_RS07545	COG3178	'Phosphotransferase
I6G67_RS07550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G67_RS07560	COG1192	Involved in chromosome partitioning
I6G67_RS07565	COG1475	DNA binding
I6G67_RS07570	COG0811	peptide transport
I6G67_RS07580	COG1132	(ABC) transporter
I6G67_RS07585	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G67_RS07605	COG0084	hydrolase, TatD family'
I6G67_RS07640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G67_RS07650	COG0590	tRNA wobble adenosine to inosine editing
I6G67_RS07670	COG0776	regulation of translation
I6G67_RS07685	COG2431	L-lysine efflux transmembrane transporter activity
I6G67_RS07700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G67_RS07705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G67_RS07725	COG1253	flavin adenine dinucleotide binding
I6G67_RS07750	COG0308	aminopeptidase N
I6G67_RS07760	COG0589	response to stress
I6G67_RS07775	COG2076	Multidrug Resistance protein
I6G67_RS07780	COG1309	transcriptional regulator
I6G67_RS07785	COG3135	benzoate transporter
I6G67_RS07795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G67_RS07800	COG0583	DNA-binding transcription factor activity
I6G67_RS07815	COG0183	Belongs to the thiolase family
I6G67_RS07820	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS07840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G67_RS07845	COG0824	Thioesterase
I6G67_RS07850	COG1454	alcohol dehydrogenase
I6G67_RS07855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G67_RS07875	COG0069	glutamate synthase activity
I6G67_RS07880	COG2197	response regulator
I6G67_RS07885	COG4585	Histidine kinase
I6G67_RS07890	COG2850	peptidyl-arginine hydroxylation
I6G67_RS07905	COG0424	maF-like protein
I6G67_RS07915	COG0126	phosphoglycerate kinase activity
I6G67_RS07930	COG0697	spore germination
I6G67_RS07960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G67_RS07965	COG3781	membrane
I6G67_RS07995	COG0506	proline dehydrogenase activity
I6G67_RS07995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G67_RS07995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G67_RS08005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G67_RS08010	COG1027	Aspartate ammonia-lyase
I6G67_RS08020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G67_RS08050	COG0316	Belongs to the HesB IscA family
I6G67_RS08055	COG0822	iron-sulfur transferase activity
I6G67_RS08065	COG1959	2 iron, 2 sulfur cluster binding
I6G67_RS08080	COG0776	regulation of translation
I6G67_RS08085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G67_RS08110	COG0537	adenosine 5'-monophosphoramidase activity
I6G67_RS08160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G67_RS08190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G67_RS08200	COG0133	tryptophan synthase activity
I6G67_RS08205	COG0517	IMP dehydrogenase activity
I6G67_RS08230	COG0612	Peptidase, M16
I6G67_RS08235	COG0552	protein localization to endoplasmic reticulum
I6G67_RS08290	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS08295	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS08340	COG2199	diguanylate cyclase activity
I6G67_RS08350	COG2814	Major facilitator Superfamily
I6G67_RS08375	COG0864	Transcriptional regulator
I6G67_RS08445	COG0596	Alpha beta hydrolase
I6G67_RS08535	COG2801	Transposase and inactivated derivatives
I6G67_RS08605	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_RS08650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G67_RS08655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G67_RS08665	COG3293	Transposase
I6G67_RS08670	COG0456	acetyltransferase
I6G67_RS08675	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_RS08685	COG1063	alcohol dehydrogenase
I6G67_RS08695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G67_RS08840	COG2814	Major facilitator Superfamily
I6G67_RS08845	COG0583	DNA-binding transcription factor activity
I6G67_RS08850	COG4948	Mandelate Racemase Muconate Lactonizing
I6G67_RS08855	COG4829	muconolactone delta-isomerase
I6G67_RS08865	COG4638	Rieske (2fe-2S)
I6G67_RS08870	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6G67_RS08875	COG0633	Ferredoxin
I6G67_RS08875	COG0543	2 iron, 2 sulfur cluster binding
I6G67_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS08885	COG3135	benzoate transporter
I6G67_RS08890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G67_RS08895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_RS08900	COG0183	Belongs to the thiolase family
I6G67_RS08905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_RS08915	COG0511	ligase activity, forming carbon-carbon bonds
I6G67_RS08930	COG0439	Biotin carboxylase
I6G67_RS08945	COG0583	DNA-binding transcription factor activity
I6G67_RS08950	COG0183	Belongs to the thiolase family
I6G67_RS08960	COG3293	Transposase
I6G67_RS08965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G67_RS08970	COG0640	Transcriptional regulator
I6G67_RS08990	COG3122	Protein conserved in bacteria
I6G67_RS08995	COG0668	transmembrane transport
I6G67_RS09005	COG1132	(ABC) transporter
I6G67_RS09020	COG2814	Major facilitator Superfamily
I6G67_RS09030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G67_RS09055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6G67_RS09060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G67_RS09115	COG3293	Transposase
I6G67_RS09170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G67_RS09200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G67_RS09205	COG0583	DNA-binding transcription factor activity
I6G67_RS09210	COG1380	Effector of murein hydrolase LrgA
I6G67_RS09215	COG1346	cytolysis
I6G67_RS09230	COG2223	nitrite transmembrane transporter activity
I6G67_RS09245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G67_RS09250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G67_RS09255	COG2207	Transcriptional regulator
I6G67_RS09260	COG1944	ATP diphosphatase activity
I6G67_RS09265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G67_RS09285	COG0730	response to heat
I6G67_RS09290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G67_RS09460	COG0204	Acyl-transferase
I6G67_RS09500	COG1464	Belongs to the NlpA lipoprotein family
I6G67_RS09505	COG1464	Belongs to the NlpA lipoprotein family
I6G67_RS09510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G67_RS09515	COG2011	ABC-type metal ion transport system permease component
I6G67_RS09525	COG0012	GTP binding
I6G67_RS09550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G67_RS09565	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G67_RS09595	COG0386	Belongs to the glutathione peroxidase family
I6G67_RS09600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G67_RS09605	COG0436	Aminotransferase
I6G67_RS09625	COG3634	alkyl hydroperoxide reductase activity
I6G67_RS09650	COG2070	2-Nitropropane dioxygenase
I6G67_RS09660	COG3038	cytochrome b561
I6G67_RS09680	COG1278	Cold shock
I6G67_RS09690	COG0604	alcohol dehydrogenase
I6G67_RS09695	COG1733	regulation of RNA biosynthetic process
I6G67_RS09715	COG3293	Transposase
I6G67_RS09765	COG1309	transcriptional regulator
I6G67_RS09790	COG0842	Transport permease protein
I6G67_RS09795	COG0842	Transport permease protein
I6G67_RS09800	COG1131	(ABC) transporter
I6G67_RS09840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G67_RS09860	COG1404	Belongs to the peptidase S8 family
I6G67_RS09865	COG4771	TonB-dependent receptor
I6G67_RS09880	COG2801	Transposase and inactivated derivatives
I6G67_RS09900	COG0714	Associated with various cellular activities
I6G67_RS09910	COG2879	small protein
I6G67_RS09915	COG1966	Carbon starvation protein
I6G67_RS09920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G67_RS09940	COG0254	rRNA binding
I6G67_RS09960	COG1067	ATP-dependent peptidase activity
I6G67_RS09965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G67_RS09970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G67_RS09975	COG0616	signal peptide processing
I6G67_RS09980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G67_RS09990	COG0573	inorganic phosphate transmembrane transporter activity
I6G67_RS09995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G67_RS10005	COG0076	glutamate decarboxylase activity
I6G67_RS10010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G67_RS10025	COG0671	phosphoesterase, PA-phosphatase related
I6G67_RS10030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G67_RS10040	COG1733	regulation of RNA biosynthetic process
I6G67_RS10045	COG0702	epimerase
I6G67_RS10075	COG0556	nucleotide-excision repair
I6G67_RS10090	COG2199	diguanylate cyclase activity
I6G67_RS10100	COG0436	Aminotransferase
I6G67_RS10135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G67_RS10140	COG1381	Involved in DNA repair and RecF pathway recombination
I6G67_RS10150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G67_RS10165	COG0681	Belongs to the peptidase S26 family
I6G67_RS10210	COG3772	lysozyme
I6G67_RS10325	COG4383	Mu-like prophage protein gp29
I6G67_RS10500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G67_RS10515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G67_RS10520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G67_RS10530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G67_RS10545	COG4208	sulfate ABC transporter
I6G67_RS10550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G67_RS10555	COG0583	DNA-binding transcription factor activity
I6G67_RS10575	COG0602	queuosine metabolic process
I6G67_RS10580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G67_RS10600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G67_RS10610	COG0583	DNA-binding transcription factor activity
I6G67_RS10615	COG2353	YceI-like domain
I6G67_RS10620	COG1056	cytidyltransferase-related domain
I6G67_RS10620	COG1051	belongs to the nudix hydrolase family
I6G67_RS10625	COG1024	Enoyl-CoA hydratase
I6G67_RS10630	COG0778	Nitroreductase
I6G67_RS10635	COG3323	Protein of unknown function (DUF1653)
I6G67_RS10635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G67_RS10645	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G67_RS10645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G67_RS10660	COG2255	four-way junction helicase activity
I6G67_RS10675	COG0824	Thioesterase
I6G67_RS10695	COG0823	Involved in the tonB-independent uptake of proteins
I6G67_RS10715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G67_RS10745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G67_RS10750	COG0628	permease
I6G67_RS10755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G67_RS10760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G67_RS10780	COG2333	competence protein COMEC
I6G67_RS10780	COG0658	competence protein
I6G67_RS10785	COG1136	(ABC) transporter
I6G67_RS10790	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G67_RS10805	COG1671	Belongs to the UPF0178 family
I6G67_RS10820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G67_RS10825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G67_RS10830	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS10870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6G67_RS10875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G67_RS10880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G67_RS10885	COG1716	ATPase activity
I6G67_RS10885	COG5001	Diguanylate cyclase
I6G67_RS10890	COG0280	phosphate acetyltransferase
I6G67_RS10890	COG0281	malic enzyme
I6G67_RS10905	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6G67_RS10920	COG1773	rubredoxin
I6G67_RS10925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G67_RS10970	COG1024	Enoyl-CoA hydratase
I6G67_RS10975	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS10980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G67_RS11005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G67_RS11025	COG0583	DNA-binding transcription factor activity
I6G67_RS11035	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G67_RS11035	COG1902	pentaerythritol trinitrate reductase activity
I6G67_RS11040	COG0277	FAD linked oxidase domain protein
I6G67_RS11050	COG2186	Transcriptional regulator
I6G67_RS11065	COG4251	negative regulation of phosphorylation
I6G67_RS11065	COG2203	Gaf domain
I6G67_RS11065	COG3706	GGDEF domain
I6G67_RS11065	COG5001	Diguanylate cyclase
I6G67_RS11070	COG0418	dihydroorotase activity
I6G67_RS11075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G67_RS11090	COG0833	amino acid
I6G67_RS11100	COG0833	amino acid
I6G67_RS11125	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6G67_RS11140	COG4172	Belongs to the ABC transporter superfamily
I6G67_RS11145	COG4239	(ABC) transporter, permease
I6G67_RS11150	COG4174	ABC transporter (Permease)
I6G67_RS11155	COG4166	transmembrane transport
I6G67_RS11160	COG0741	lytic transglycosylase activity
I6G67_RS11160	COG1388	LysM domain
I6G67_RS11165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G67_RS11175	COG2816	NAD+ diphosphatase activity
I6G67_RS11180	COG0657	acetylesterase activity
I6G67_RS11200	COG0583	DNA-binding transcription factor activity
I6G67_RS11205	COG1388	LysM domain
I6G67_RS11205	COG4942	peptidase
I6G67_RS11215	COG0582	viral genome integration into host DNA
I6G67_RS11515	COG0753	catalase activity
I6G67_RS11530	COG0789	Transcriptional regulator
I6G67_RS11545	COG1686	Belongs to the peptidase S11 family
I6G67_RS11550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G67_RS11555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G67_RS11560	COG2267	carboxylic ester hydrolase activity
I6G67_RS11565	COG2453	phosphatase
I6G67_RS11565	COG0671	phosphoesterase, PA-phosphatase related
I6G67_RS11580	COG4589	Belongs to the CDS family
I6G67_RS11595	COG2915	High frequency lysogenization protein hflD homolog
I6G67_RS11615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G67_RS11620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G67_RS11625	COG2801	Transposase and inactivated derivatives
I6G67_RS11635	COG2801	Transposase and inactivated derivatives
I6G67_RS11645	COG0006	proline dipeptidase activity
I6G67_RS11705	COG1785	Belongs to the alkaline phosphatase family
I6G67_RS11710	COG1785	Belongs to the alkaline phosphatase family
I6G67_RS11725	COG4770	biotin carboxylase activity
I6G67_RS11745	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G67_RS11750	COG0583	DNA-binding transcription factor activity
I6G67_RS11760	COG2217	Heavy metal translocating P-type atpase
I6G67_RS11770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G67_RS11785	COG2234	aminopeptidase activity
I6G67_RS11795	COG3384	dioxygenase
I6G67_RS11805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G67_RS11810	COG2878	Part of a membrane complex involved in electron transport
I6G67_RS11815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G67_RS11840	COG0768	penicillin binding
I6G67_RS11845	COG0742	ribosomal rna small subunit methyltransferase
I6G67_RS11875	COG3119	arylsulfatase activity
I6G67_RS11895	COG1388	LysM domain
I6G67_RS11895	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G67_RS11920	COG1597	lipid kinase activity
I6G67_RS11925	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6G67_RS11935	COG0477	Major facilitator Superfamily
I6G67_RS11950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G67_RS11975	COG0604	alcohol dehydrogenase
I6G67_RS11975	COG4221	oxidoreductase activity
I6G67_RS11975	COG3321	synthase
I6G67_RS11975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G67_RS11990	COG1695	Transcriptional regulator
I6G67_RS12000	COG0210	DNA helicase
I6G67_RS12035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G67_RS12040	COG1773	rubredoxin
I6G67_RS12045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_RS12055	COG0583	DNA-binding transcription factor activity
I6G67_RS12070	COG0705	Rhomboid family
I6G67_RS12070	COG0457	Tetratricopeptide repeat
I6G67_RS12075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G67_RS12080	COG4181	ATPase activity
I6G67_RS12105	COG4771	TonB-dependent receptor
I6G67_RS12130	COG0306	phosphate transporter
I6G67_RS12145	COG2852	Protein conserved in bacteria
I6G67_RS12160	COG2223	nitrite transmembrane transporter activity
I6G67_RS12170	COG0242	peptide deformylase activity
I6G67_RS12175	COG0477	Major facilitator Superfamily
I6G67_RS12220	COG2199	diguanylate cyclase activity
I6G67_RS12220	COG2203	Gaf domain
I6G67_RS12230	COG4681	YaeQ
I6G67_RS12235	COG0523	cobalamin synthesis protein
I6G67_RS12245	COG1607	acyl-coa hydrolase
I6G67_RS12250	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G67_RS12260	COG1115	amino acid carrier protein
I6G67_RS12265	COG0786	glutamate:sodium symporter activity
I6G67_RS12280	COG2814	Major facilitator Superfamily
I6G67_RS12285	COG1289	transmembrane transporter activity
I6G67_RS12295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G67_RS12365	COG2832	Protein of unknown function (DUF454)
I6G67_RS12380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G67_RS12390	COG0643	Histidine kinase
I6G67_RS12390	COG0784	Response regulator, receiver
I6G67_RS12390	COG2198	Histidine kinase
I6G67_RS12395	COG0840	transmembrane signaling receptor activity
I6G67_RS12445	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_RS12475	COG2358	TRAP transporter, solute receptor (TAXI family
I6G67_RS12490	COG0489	protein tyrosine kinase activity
I6G67_RS12510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G67_RS12510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G67_RS12520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G67_RS12545	COG4716	Myosin-crossreactive antigen
I6G67_RS12575	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G67_RS12580	COG2081	HI0933 family
I6G67_RS12595	COG0668	transmembrane transport
I6G67_RS12615	COG0765	amino acid transport
I6G67_RS12620	COG0765	amino acid transport
I6G67_RS12625	COG1126	abc transporter atp-binding protein
I6G67_RS12635	COG0004	ammonium transporteR
I6G67_RS12640	COG0546	phosphoglycolate phosphatase activity
I6G67_RS12650	COG0642	Histidine kinase
I6G67_RS12655	COG0745	RESPONSE REGULATOR receiver
I6G67_RS12680	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G67_RS12695	COG0142	geranyltranstransferase activity
I6G67_RS12700	COG2828	Protein conserved in bacteria
I6G67_RS12705	COG1113	amino acid transport
I6G67_RS12720	COG1113	amino acid transport
I6G67_RS12730	COG2433	Pfam Transposase IS66
I6G67_RS12755	COG0625	glutathione transferase activity
I6G67_RS12770	COG0431	NADPH-dependent FMN reductase
I6G67_RS12775	COG0798	PFAM Bile acid sodium symporter
I6G67_RS12785	COG0640	Transcriptional regulator
I6G67_RS12835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G67_RS12850	COG2433	Pfam Transposase IS66
I6G67_RS12860	COG0424	maF-like protein
I6G67_RS12865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G67_RS12870	COG1792	Involved in formation and maintenance of cell shape
I6G67_RS12875	COG1077	Cell shape determining protein MreB Mrl
I6G67_RS12880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G67_RS12890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G67_RS12905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G67_RS12915	COG3293	Transposase
I6G67_RS12940	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6G67_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS12970	COG0583	DNA-binding transcription factor activity
I6G67_RS12980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_RS12990	COG4772	TonB-dependent receptor
I6G67_RS12995	COG4993	Dehydrogenase
I6G67_RS13000	COG3659	wide pore channel activity
I6G67_RS13005	COG3420	alginic acid biosynthetic process
I6G67_RS13010	COG0710	3-dehydroquinate dehydratase activity
I6G67_RS13015	COG3485	protocatechuate 3,4-dioxygenase
I6G67_RS13020	COG3485	protocatechuate 3,4-dioxygenase
I6G67_RS13025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G67_RS13030	COG2271	Major facilitator Superfamily
I6G67_RS13035	COG0596	Alpha beta hydrolase
I6G67_RS13040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G67_RS13045	COG0183	Belongs to the thiolase family
I6G67_RS13050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_RS13055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G67_RS13060	COG1414	Transcriptional regulator
I6G67_RS13070	COG1113	amino acid transport
I6G67_RS13080	COG3724	N-succinylarginine dihydrolase activity
I6G67_RS13085	COG1012	belongs to the aldehyde dehydrogenase family
I6G67_RS13090	COG3138	arginine N-succinyltransferase
I6G67_RS13100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G67_RS13105	COG1522	sequence-specific DNA binding
I6G67_RS13125	COG1012	belongs to the aldehyde dehydrogenase family
I6G67_RS13130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G67_RS13140	COG1113	amino acid transport
I6G67_RS13145	COG4772	TonB-dependent receptor
I6G67_RS13155	COG1271	oxidase subunit
I6G67_RS13160	COG1294	oxidase, subunit
I6G67_RS13170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G67_RS13180	COG1346	cytolysis
I6G67_RS13190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_RS13200	COG1522	sequence-specific DNA binding
I6G67_RS13215	COG2814	Major facilitator Superfamily
I6G67_RS13240	COG0732	type I restriction modification DNA specificity domain
I6G67_RS13270	COG2184	nucleotidyltransferase activity
I6G67_RS13300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G67_RS13305	COG2814	Major facilitator Superfamily
I6G67_RS13310	COG1566	PFAM secretion protein HlyD family protein
I6G67_RS13315	COG2050	protein possibly involved in aromatic compounds catabolism
I6G67_RS13330	COG1090	epimerase
I6G67_RS13340	COG5001	Diguanylate cyclase
I6G67_RS13340	COG4251	negative regulation of phosphorylation
I6G67_RS13340	COG3706	GGDEF domain
I6G67_RS13340	COG2203	Gaf domain
I6G67_RS13345	COG0420	3'-5' exonuclease activity
I6G67_RS13375	COG0735	belongs to the Fur family
I6G67_RS13380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G67_RS13385	COG2914	Belongs to the UPF0125 (RnfH) family
I6G67_RS13400	COG0121	glutamine amidotransferase
I6G67_RS13425	COG0756	dUTP diphosphatase activity
I6G67_RS13430	COG0210	DNA helicase
I6G67_RS13435	COG2885	chlorophyll binding
I6G67_RS13440	COG0204	Acyl-transferase
I6G67_RS13450	COG0850	regulation of cytokinetic process
I6G67_RS13455	COG2894	cell division
I6G67_RS13460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G67_RS13475	COG0531	amino acid
I6G67_RS13475	COG1674	ftsk spoiiie
I6G67_RS13480	COG0492	ferredoxin-NADP+ reductase activity
I6G67_RS13485	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G67_RS13495	COG0456	acetyltransferase
I6G67_RS13515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G67_RS13530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G67_RS13545	COG1981	membrane
I6G67_RS13555	COG1113	amino acid transport
I6G67_RS13560	COG0251	oxidation-reduction process
I6G67_RS13600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G67_RS13625	COG2132	Multicopper oxidase
I6G67_RS13635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G67_RS13670	COG1968	undecaprenyl-diphosphatase activity
I6G67_RS13675	COG1214	PFAM Peptidase M22, glycoprotease
I6G67_RS13680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G67_RS13685	COG0494	nUDIX hydrolase
I6G67_RS13735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G67_RS13745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G67_RS13810	COG2853	Lipoprotein
I6G67_RS13815	COG2208	phosphoserine phosphatase activity
I6G67_RS13825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G67_RS13830	COG1764	response to oxidative stress
I6G67_RS13860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G67_RS13860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G67_RS13875	COG0037	tRNA processing
I6G67_RS13885	COG0248	Ppx GppA phosphatase
I6G67_RS13910	COG0072	phenylalanine-tRNA ligase activity
I6G67_RS13960	COG1238	metal cluster binding
I6G67_RS13970	COG0625	glutathione transferase activity
I6G67_RS13990	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_RS13995	COG3028	Belongs to the UPF0307 family
I6G67_RS14005	COG1660	Displays ATPase and GTPase activities
I6G67_RS14010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G67_RS14020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G67_RS14025	COG0617	tRNA 3'-terminal CCA addition
I6G67_RS14030	COG1555	photosystem II stabilization
I6G67_RS14035	COG3956	TIGRFAM MazG family protein
I6G67_RS14045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G67_RS14060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G67_RS14065	COG0784	Response regulator, receiver
I6G67_RS14065	COG5002	protein histidine kinase activity
I6G67_RS14065	COG2205	protein histidine kinase activity
I6G67_RS14070	COG1024	Enoyl-CoA hydratase
I6G67_RS14075	COG2084	Dehydrogenase
I6G67_RS14080	COG3622	Belongs to the hyi family
I6G67_RS14095	COG0004	ammonium transporteR
I6G67_RS14120	COG2814	Major facilitator Superfamily
I6G67_RS14140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G67_RS14150	COG0732	type I restriction modification DNA specificity domain
I6G67_RS14160	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G67_RS14175	COG0174	glutamine synthetase
I6G67_RS14190	COG0745	RESPONSE REGULATOR receiver
I6G67_RS14195	COG2205	protein histidine kinase activity
I6G67_RS14205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G67_RS14210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G67_RS14290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G67_RS14305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G67_RS14315	COG0084	hydrolase, TatD family'
I6G67_RS14330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G67_RS14345	COG0793	Belongs to the peptidase S41A family
I6G67_RS14370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G67_RS14375	COG0857	belongs to the CobB CobQ family
I6G67_RS14375	COG0280	phosphate acetyltransferase
I6G67_RS14385	COG2318	DinB family
I6G67_RS14390	COG0697	spore germination
I6G67_RS14395	COG2207	Transcriptional regulator
I6G67_RS14395	COG3708	Transcriptional regulator
I6G67_RS14405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G67_RS14405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G67_RS14425	COG0740	serine-type endopeptidase activity
I6G67_RS14435	COG4771	TonB-dependent receptor
I6G67_RS14440	COG4774	siderophore transport
I6G67_RS14460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G67_RS14465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_RS14470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_RS14470	COG2813	Specifically methylates the guanine in position
I6G67_RS14575	COG0788	formyltetrahydrofolate deformylase activity
I6G67_RS14600	COG4651	solute:proton antiporter activity
I6G67_RS14600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G67_RS14625	COG0210	DNA helicase
I6G67_RS14630	COG1929	Belongs to the glycerate kinase type-1 family
I6G67_RS14675	COG2900	Belongs to the SlyX family
I6G67_RS14680	COG0488	(ABC) transporter
I6G67_RS14690	COG1560	Kdo2-lipid A biosynthetic process
I6G67_RS14745	COG0473	3-isopropylmalate dehydrogenase activity
I6G67_RS14760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G67_RS14770	COG0583	DNA-binding transcription factor activity
I6G67_RS14805	COG1280	lysine exporter protein (LysE YggA)
I6G67_RS14820	COG1960	acyl-CoA dehydrogenase activity
I6G67_RS14845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6G67_RS14860	COG0583	DNA-binding transcription factor activity
I6G67_RS14875	COG0564	pseudouridine synthase activity
I6G67_RS14880	COG1530	ribonuclease E activity
I6G67_RS14885	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_RS14910	COG1983	PspC domain protein
I6G67_RS14930	COG0751	glycine-tRNA ligase activity
I6G67_RS14965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G67_RS14980	COG2226	methyltransferase
I6G67_RS14995	COG0493	'glutamate synthase
I6G67_RS14995	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G67_RS15005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6G67_RS15010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G67_RS15015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G67_RS15025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G67_RS15035	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G67_RS15035	COG0644	oxidoreductase
I6G67_RS15065	COG0425	Belongs to the sulfur carrier protein TusA family
I6G67_RS15070	COG4535	Mg2 and Co2 transporter CorC
I6G67_RS15075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G67_RS15080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G67_RS15100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G67_RS15110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G67_RS15130	COG2841	Protein conserved in bacteria
I6G67_RS15135	COG0598	Magnesium transport protein CorA
I6G67_RS15140	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G67_RS15150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G67_RS15155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G67_RS15160	COG1074	ATP-dependent DNA helicase activity
I6G67_RS15165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G67_RS15185	COG2226	methyltransferase
I6G67_RS15195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G67_RS15210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G67_RS15220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G67_RS15225	COG2111	Na H antiporter
I6G67_RS15225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G67_RS15230	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G67_RS15235	COG0651	ATP synthesis coupled electron transport
I6G67_RS15240	COG1863	multisubunit Na H antiporter MnhE subunit
I6G67_RS15245	COG2212	antiporter activity
I6G67_RS15250	COG1320	monovalent cation:proton antiporter activity
I6G67_RS15255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G67_RS15265	COG0195	Participates in both transcription termination and antitermination
I6G67_RS15325	COG0237	dephospho-CoA kinase activity
I6G67_RS15335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G67_RS15345	COG0497	DNA recombination
I6G67_RS15350	COG1678	Uncharacterized ACR, COG1678
I6G67_RS15355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G67_RS15370	COG1289	transmembrane transporter activity
I6G67_RS15385	COG1132	(ABC) transporter
I6G67_RS15395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G67_RS15445	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_RS15485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G67_RS15515	COG0326	Molecular chaperone. Has ATPase activity
I6G67_RS15525	COG3047	cAMP biosynthetic process
I6G67_RS15530	COG2056	Na+-H+ antiporter family
I6G67_RS15560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G67_RS15565	COG0085	RNA polymerase activity
I6G67_RS15570	COG0222	ribosome binding
I6G67_RS15575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G67_RS15580	COG0081	regulation of translation
I6G67_RS15585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G67_RS15605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G67_RS15635	COG0546	phosphoglycolate phosphatase activity
I6G67_RS15665	COG0824	Thioesterase
I6G67_RS15685	COG0181	hydroxymethylbilane synthase activity
I6G67_RS15695	COG3275	phosphorelay sensor kinase activity
I6G67_RS15715	COG1538	Outer membrane efflux protein
I6G67_RS15725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G67_RS15735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G67_RS15740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G67_RS15745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G67_RS15750	COG0772	Belongs to the SEDS family
I6G67_RS15755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G67_RS15775	COG4974	Belongs to the 'phage' integrase family
I6G67_RS15780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G67_RS15790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G67_RS15795	COG1686	Belongs to the peptidase S11 family
I6G67_RS15800	COG2197	response regulator
I6G67_RS15815	COG0793	Belongs to the peptidase S41A family
I6G67_RS15820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G67_RS15825	COG0795	lipopolysaccharide-transporting ATPase activity
I6G67_RS15830	COG0795	lipopolysaccharide-transporting ATPase activity
I6G67_RS15850	COG0586	Pfam SNARE associated Golgi protein
I6G67_RS15865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G67_RS15865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G67_RS15875	COG0004	ammonium transporteR
I6G67_RS15880	COG0347	Belongs to the P(II) protein family
I6G67_RS15905	COG0625	glutathione transferase activity
I6G67_RS15960	COG0606	chelatase, subunit chli
I6G67_RS15980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G67_RS15995	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_RS16005	COG0477	Major facilitator Superfamily
I6G67_RS16010	COG2860	membrane
I6G67_RS16015	COG3012	SEC-C Motif Domain Protein
I6G67_RS16020	COG1253	flavin adenine dinucleotide binding
I6G67_RS16040	COG2814	Major facilitator Superfamily
I6G67_RS16050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G67_RS16125	COG0758	DNA mediated transformation
I6G67_RS16135	COG0697	spore germination
I6G67_RS16150	COG0386	Belongs to the glutathione peroxidase family
I6G67_RS16185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G67_RS16235	COG1121	(ABC) transporter
I6G67_RS16240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G67_RS16245	COG1683	Conserved Protein
I6G67_RS16255	COG2837	iron assimilation
I6G67_RS16280	COG0281	malic enzyme
I6G67_RS16325	COG1715	Restriction endonuclease
I6G67_RS16330	COG0519	Catalyzes the synthesis of GMP from XMP
I6G67_RS16330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G67_RS16335	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G67_RS16345	COG0586	Pfam SNARE associated Golgi protein
I6G67_RS16360	COG1192	Involved in chromosome partitioning
I6G67_RS16370	COG0271	Belongs to the BolA IbaG family
I6G67_RS16410	COG3756	Protein conserved in bacteria
I6G67_RS16430	COG4372	Transposase
I6G67_RS16505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G67_RS16510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G67_RS16510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G67_RS16510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G67_RS16515	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G67_RS16520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G67_RS16520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G67_RS16535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G67_RS16540	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS16580	COG2986	histidine ammonia-lyase
I6G67_RS16595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G67_RS16605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G67_RS16610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G67_RS16625	COG0583	DNA-binding transcription factor activity
I6G67_RS16630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G67_RS16645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G67_RS16655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G67_RS16660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G67_RS16670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G67_RS16715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G67_RS16725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G67_RS16740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G67_RS16750	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6G67_RS16750	COG0662	Cupin 2, conserved barrel domain protein
I6G67_RS16755	COG0297	glycogen (starch) synthase activity
I6G67_RS16760	COG0438	transferase activity, transferring glycosyl groups
I6G67_RS16770	COG1215	transferase activity, transferring glycosyl groups
I6G67_RS16815	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G67_RS16825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G67_RS16835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G67_RS16840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G67_RS16845	COG0438	transferase activity, transferring glycosyl groups
I6G67_RS16850	COG0438	transferase activity, transferring glycosyl groups
I6G67_RS16855	COG0438	transferase activity, transferring glycosyl groups
I6G67_RS16880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G67_RS16910	COG0728	peptidoglycan biosynthetic process
I6G67_RS16915	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G67_RS16925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G67_RS16935	COG3307	-O-antigen
I6G67_RS16940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G67_RS16945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G67_RS16950	COG0546	phosphoglycolate phosphatase activity
I6G67_RS16955	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_RS16990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G67_RS16990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G67_RS16995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_RS17000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_RS17005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G67_RS17010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G67_RS17015	COG1116	anion transmembrane transporter activity
I6G67_RS17020	COG1309	transcriptional regulator
I6G67_RS17035	COG0196	riboflavin kinase activity
I6G67_RS17040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G67_RS17045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G67_RS17050	COG1047	Peptidyl-prolyl cis-trans
I6G67_RS17065	COG2133	pyrroloquinoline quinone binding
I6G67_RS17095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G67_RS17100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G67_RS17105	COG2951	lytic endotransglycosylase activity
I6G67_RS17110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G67_RS17125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G67_RS17145	COG0861	Integral membrane protein TerC family
I6G67_RS17155	COG0754	glutathionylspermidine amidase activity
I6G67_RS17165	COG0402	S-adenosylhomocysteine deaminase activity
I6G67_RS17185	COG1230	cation diffusion facilitator family transporter
I6G67_RS17280	COG2433	Pfam Transposase IS66
I6G67_RS17295	COG0582	viral genome integration into host DNA
I6G67_RS17305	COG0706	membrane insertase activity
I6G67_RS17310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G67_RS17325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G67_RS17330	COG0592	DNA-directed DNA polymerase activity
I6G67_RS17340	COG0187	DNA topoisomerase II activity
I6G67_RS17350	COG0488	(ABC) transporter
I6G67_RS17390	COG0443	Heat shock 70 kDa protein
I6G67_RS17410	COG0657	acetylesterase activity
I6G67_RS17420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G67_RS17450	COG2814	Major facilitator Superfamily
I6G67_RS17460	COG0733	neurotransmitter:sodium symporter activity
I6G67_RS17490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G67_RS17490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G67_RS17510	COG0129	dihydroxy-acid dehydratase activity
I6G67_RS17520	COG4774	siderophore transport
I6G67_RS17530	COG0583	DNA-binding transcription factor activity
I6G67_RS17535	COG2233	PERMEase
I6G67_RS17545	COG1309	transcriptional regulator
I6G67_RS17565	COG0484	heat shock protein binding
I6G67_RS17575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G67_RS17590	COG0436	Aminotransferase
I6G67_RS17595	COG1064	alcohol dehydrogenase
I6G67_RS17600	COG2818	Glycosylase
I6G67_RS17630	COG5487	UPF0391 membrane protein
I6G67_RS17635	COG2983	Belongs to the UPF0260 family
I6G67_RS17640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G67_RS17660	COG4160	amino acid transport
I6G67_RS17665	COG4215	(ABC) transporter
I6G67_RS17685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G67_RS17690	COG1335	isochorismatase
I6G67_RS17695	COG0385	Bile acid
I6G67_RS17765	COG0534	Mate efflux family protein
I6G67_RS17770	COG0436	Aminotransferase