locus-tag	class	description
DT536_RS00010	COG1289	transmembrane transporter activity
DT536_RS00020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DT536_RS00090	COG2832	Protein of unknown function (DUF454)
DT536_RS00105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DT536_RS00115	COG0643	Histidine kinase
DT536_RS00115	COG2198	Histidine kinase
DT536_RS00115	COG0784	Response regulator, receiver
DT536_RS00120	COG0840	transmembrane signaling receptor activity
DT536_RS00190	COG2358	TRAP transporter, solute receptor (TAXI family
DT536_RS00205	COG0489	protein tyrosine kinase activity
DT536_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DT536_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DT536_RS00240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DT536_RS00265	COG4716	Myosin-crossreactive antigen
DT536_RS00295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DT536_RS00300	COG2081	HI0933 family
DT536_RS00310	COG0668	transmembrane transport
DT536_RS00330	COG0765	amino acid transport
DT536_RS00335	COG0765	amino acid transport
DT536_RS00340	COG1126	abc transporter atp-binding protein
DT536_RS00350	COG0004	ammonium transporteR
DT536_RS00355	COG0546	phosphoglycolate phosphatase activity
DT536_RS00365	COG0642	Histidine kinase
DT536_RS00370	COG0745	RESPONSE REGULATOR receiver
DT536_RS00410	COG1752	Esterase of the alpha-beta hydrolase superfamily
DT536_RS00425	COG0142	geranyltranstransferase activity
DT536_RS00430	COG2828	Protein conserved in bacteria
DT536_RS00435	COG1113	amino acid transport
DT536_RS00450	COG1113	amino acid transport
DT536_RS00470	COG0625	glutathione transferase activity
DT536_RS00485	COG0431	NADPH-dependent FMN reductase
DT536_RS00490	COG0798	PFAM Bile acid sodium symporter
DT536_RS00500	COG0640	Transcriptional regulator
DT536_RS00555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DT536_RS00565	COG0424	maF-like protein
DT536_RS00570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DT536_RS00575	COG1792	Involved in formation and maintenance of cell shape
DT536_RS00580	COG1077	Cell shape determining protein MreB Mrl
DT536_RS00585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DT536_RS00595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DT536_RS00600	COG0653	protein targeting
DT536_RS00630	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DT536_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS00645	COG2610	gluconate transmembrane transporter activity
DT536_RS00650	COG0583	DNA-binding transcription factor activity
DT536_RS00660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DT536_RS00670	COG4772	TonB-dependent receptor
DT536_RS00690	COG1294	oxidase, subunit
DT536_RS00700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DT536_RS00710	COG1346	cytolysis
DT536_RS00720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DT536_RS00730	COG1522	sequence-specific DNA binding
DT536_RS00760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DT536_RS00830	COG0642	Histidine kinase
DT536_RS00845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DT536_RS00875	COG2323	membrane
DT536_RS00905	COG0582	viral genome integration into host DNA
DT536_RS00925	COG3177	Filamentation induced by cAMP protein fic
DT536_RS00930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DT536_RS00980	COG2801	Transposase and inactivated derivatives
DT536_RS01060	COG2184	nucleotidyltransferase activity
DT536_RS01125	COG0582	viral genome integration into host DNA
DT536_RS01135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DT536_RS01140	COG2814	Major facilitator Superfamily
DT536_RS01145	COG1566	PFAM secretion protein HlyD family protein
DT536_RS01160	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DT536_RS01175	COG2050	protein possibly involved in aromatic compounds catabolism
DT536_RS01200	COG2203	Gaf domain
DT536_RS01200	COG3706	GGDEF domain
DT536_RS01200	COG4251	negative regulation of phosphorylation
DT536_RS01200	COG5001	Diguanylate cyclase
DT536_RS01205	COG0420	3'-5' exonuclease activity
DT536_RS01235	COG0735	belongs to the Fur family
DT536_RS01240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DT536_RS01245	COG2914	Belongs to the UPF0125 (RnfH) family
DT536_RS01260	COG0121	glutamine amidotransferase
DT536_RS01275	COG0756	dUTP diphosphatase activity
DT536_RS01280	COG0210	DNA helicase
DT536_RS01285	COG2885	chlorophyll binding
DT536_RS01290	COG0204	Acyl-transferase
DT536_RS01300	COG0850	regulation of cytokinetic process
DT536_RS01305	COG2894	cell division
DT536_RS01310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DT536_RS01325	COG0531	amino acid
DT536_RS01325	COG1674	ftsk spoiiie
DT536_RS01330	COG0492	ferredoxin-NADP+ reductase activity
DT536_RS01335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DT536_RS01345	COG0456	acetyltransferase
DT536_RS01370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DT536_RS01385	COG1981	membrane
DT536_RS01395	COG1113	amino acid transport
DT536_RS01400	COG0251	oxidation-reduction process
DT536_RS01430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DT536_RS01430	COG0352	thiamine-phosphate diphosphorylase activity
DT536_RS01430	COG0351	phosphomethylpyrimidine kinase
DT536_RS01440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DT536_RS01465	COG2132	Multicopper oxidase
DT536_RS01475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DT536_RS01525	COG1968	undecaprenyl-diphosphatase activity
DT536_RS01530	COG1214	PFAM Peptidase M22, glycoprotease
DT536_RS01535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DT536_RS01540	COG0494	nUDIX hydrolase
DT536_RS01590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DT536_RS01600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DT536_RS01670	COG2853	Lipoprotein
DT536_RS01675	COG2208	phosphoserine phosphatase activity
DT536_RS01685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DT536_RS01695	COG1764	response to oxidative stress
DT536_RS01725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DT536_RS01725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DT536_RS01740	COG0037	tRNA processing
DT536_RS01750	COG0248	Ppx GppA phosphatase
DT536_RS01775	COG0072	phenylalanine-tRNA ligase activity
DT536_RS01825	COG1238	metal cluster binding
DT536_RS01835	COG0625	glutathione transferase activity
DT536_RS01855	COG0318	PFAM AMP-dependent synthetase and ligase
DT536_RS01860	COG3028	Belongs to the UPF0307 family
DT536_RS01870	COG1660	Displays ATPase and GTPase activities
DT536_RS01875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DT536_RS01885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DT536_RS01890	COG0617	tRNA 3'-terminal CCA addition
DT536_RS01895	COG1555	photosystem II stabilization
DT536_RS01900	COG3956	TIGRFAM MazG family protein
DT536_RS01910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DT536_RS01925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DT536_RS01930	COG0784	Response regulator, receiver
DT536_RS01930	COG2205	protein histidine kinase activity
DT536_RS01930	COG5002	protein histidine kinase activity
DT536_RS01935	COG1024	Enoyl-CoA hydratase
DT536_RS01940	COG2084	Dehydrogenase
DT536_RS01945	COG3622	Belongs to the hyi family
DT536_RS01960	COG0004	ammonium transporteR
DT536_RS01985	COG2814	Major facilitator Superfamily
DT536_RS02045	COG0210	DNA helicase
DT536_RS02050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DT536_RS02135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DT536_RS02150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DT536_RS02160	COG0084	hydrolase, TatD family'
DT536_RS02175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DT536_RS02185	COG0793	Belongs to the peptidase S41A family
DT536_RS02200	COG2267	carboxylic ester hydrolase activity
DT536_RS02210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DT536_RS02215	COG0280	phosphate acetyltransferase
DT536_RS02215	COG0857	belongs to the CobB CobQ family
DT536_RS02225	COG2318	DinB family
DT536_RS02230	COG0697	spore germination
DT536_RS02235	COG2207	Transcriptional regulator
DT536_RS02235	COG1917	Cupin 2, conserved barrel domain protein
DT536_RS02245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DT536_RS02245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DT536_RS02265	COG0740	serine-type endopeptidase activity
DT536_RS02280	COG4774	siderophore transport
DT536_RS02295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DT536_RS02305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DT536_RS02305	COG2813	Specifically methylates the guanine in position
DT536_RS02410	COG0788	formyltetrahydrofolate deformylase activity
DT536_RS02435	COG4651	solute:proton antiporter activity
DT536_RS02435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DT536_RS02460	COG0210	DNA helicase
DT536_RS02505	COG2900	Belongs to the SlyX family
DT536_RS02510	COG0488	(ABC) transporter
DT536_RS02515	COG1560	Kdo2-lipid A biosynthetic process
DT536_RS02575	COG0473	3-isopropylmalate dehydrogenase activity
DT536_RS02590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DT536_RS02600	COG0583	DNA-binding transcription factor activity
DT536_RS02635	COG1280	lysine exporter protein (LysE YggA)
DT536_RS02650	COG1960	acyl-CoA dehydrogenase activity
DT536_RS02670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DT536_RS02685	COG0583	DNA-binding transcription factor activity
DT536_RS02700	COG0564	pseudouridine synthase activity
DT536_RS02710	COG1530	ribonuclease E activity
DT536_RS02715	COG0318	PFAM AMP-dependent synthetase and ligase
DT536_RS02740	COG1983	PspC domain protein
DT536_RS02765	COG0751	glycine-tRNA ligase activity
DT536_RS02790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DT536_RS02805	COG2226	methyltransferase
DT536_RS02820	COG0493	'glutamate synthase
DT536_RS02820	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DT536_RS02830	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DT536_RS02840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DT536_RS02845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DT536_RS02855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DT536_RS02865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DT536_RS02865	COG0644	oxidoreductase
DT536_RS02890	COG0425	Belongs to the sulfur carrier protein TusA family
DT536_RS02895	COG4535	Mg2 and Co2 transporter CorC
DT536_RS02900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DT536_RS02905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DT536_RS02925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DT536_RS02935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DT536_RS02955	COG2841	Protein conserved in bacteria
DT536_RS02960	COG0598	Magnesium transport protein CorA
DT536_RS02965	COG1185	polyribonucleotide nucleotidyltransferase activity
DT536_RS02975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DT536_RS02980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DT536_RS02985	COG1074	ATP-dependent DNA helicase activity
DT536_RS02990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DT536_RS03020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DT536_RS03035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DT536_RS03045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DT536_RS03050	COG2111	Na H antiporter
DT536_RS03050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DT536_RS03055	COG1006	Multisubunit Na H antiporter MnhC subunit
DT536_RS03060	COG0651	ATP synthesis coupled electron transport
DT536_RS03065	COG1863	multisubunit Na H antiporter MnhE subunit
DT536_RS03070	COG2212	antiporter activity
DT536_RS03075	COG1320	monovalent cation:proton antiporter activity
DT536_RS03080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DT536_RS03090	COG0195	Participates in both transcription termination and antitermination
DT536_RS03145	COG0237	dephospho-CoA kinase activity
DT536_RS03155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DT536_RS03165	COG0497	DNA recombination
DT536_RS03175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DT536_RS03190	COG1289	transmembrane transporter activity
DT536_RS03205	COG1132	(ABC) transporter
DT536_RS03210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DT536_RS03280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DT536_RS03315	COG0326	Molecular chaperone. Has ATPase activity
DT536_RS03325	COG3047	cAMP biosynthetic process
DT536_RS03330	COG2056	Na+-H+ antiporter family
DT536_RS03355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DT536_RS03360	COG0085	RNA polymerase activity
DT536_RS03365	COG0222	ribosome binding
DT536_RS03370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DT536_RS03375	COG0081	regulation of translation
DT536_RS03380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DT536_RS03430	COG0546	phosphoglycolate phosphatase activity
DT536_RS03460	COG0824	Thioesterase
DT536_RS03480	COG0181	hydroxymethylbilane synthase activity
DT536_RS03490	COG3275	phosphorelay sensor kinase activity
DT536_RS03510	COG1538	Outer membrane efflux protein
DT536_RS03530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DT536_RS03535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DT536_RS03540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DT536_RS03545	COG0772	Belongs to the SEDS family
DT536_RS03550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DT536_RS03570	COG4974	Belongs to the 'phage' integrase family
DT536_RS03575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DT536_RS03585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DT536_RS03590	COG1686	Belongs to the peptidase S11 family
DT536_RS03595	COG2197	response regulator
DT536_RS03610	COG0793	Belongs to the peptidase S41A family
DT536_RS03615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DT536_RS03620	COG0795	lipopolysaccharide-transporting ATPase activity
DT536_RS03625	COG0795	lipopolysaccharide-transporting ATPase activity
DT536_RS03645	COG0586	Pfam SNARE associated Golgi protein
DT536_RS03660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DT536_RS03660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DT536_RS03670	COG0004	ammonium transporteR
DT536_RS03675	COG0347	Belongs to the P(II) protein family
DT536_RS03685	COG0606	chelatase, subunit chli
DT536_RS03705	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DT536_RS03720	COG0318	PFAM AMP-dependent synthetase and ligase
DT536_RS03730	COG0477	Major facilitator Superfamily
DT536_RS03735	COG2860	membrane
DT536_RS03740	COG3012	SEC-C Motif Domain Protein
DT536_RS03745	COG1253	flavin adenine dinucleotide binding
DT536_RS03765	COG2814	Major facilitator Superfamily
DT536_RS03775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DT536_RS03855	COG0758	DNA mediated transformation
DT536_RS03865	COG0697	spore germination
DT536_RS03875	COG0386	Belongs to the glutathione peroxidase family
DT536_RS03910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DT536_RS03960	COG1121	(ABC) transporter
DT536_RS03965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DT536_RS03970	COG1683	Conserved Protein
DT536_RS03980	COG2837	iron assimilation
DT536_RS03990	COG1388	LysM domain
DT536_RS03990	COG3409	Peptidoglycan-binding domain 1 protein
DT536_RS03990	COG5632	N-Acetylmuramoyl-L-alanine amidase
DT536_RS04000	COG0281	malic enzyme
DT536_RS04055	COG0519	Catalyzes the synthesis of GMP from XMP
DT536_RS04055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DT536_RS04060	COG3111	PFAM Bacterial OB fold (BOF) protein
DT536_RS04070	COG0586	Pfam SNARE associated Golgi protein
DT536_RS04085	COG1192	Involved in chromosome partitioning
DT536_RS04095	COG0271	Belongs to the BolA IbaG family
DT536_RS04135	COG3756	Protein conserved in bacteria
DT536_RS04180	COG2304	oxidoreductase activity
DT536_RS04220	COG1358	cellular component organization or biogenesis
DT536_RS04245	COG4245	von Willebrand factor, type A
DT536_RS04255	COG4245	von Willebrand factor, type A
DT536_RS04335	COG1696	Membrane protein involved in D-alanine export
DT536_RS04345	COG4372	Transposase
DT536_RS04405	COG4628	conserved protein (DUF2132)
DT536_RS04415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DT536_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS04460	COG2986	histidine ammonia-lyase
DT536_RS04475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DT536_RS04485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DT536_RS04505	COG0583	DNA-binding transcription factor activity
DT536_RS04510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DT536_RS04525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DT536_RS04535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DT536_RS04540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DT536_RS04550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DT536_RS04555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DT536_RS04565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DT536_RS04580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DT536_RS04585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DT536_RS04605	COG0438	transferase activity, transferring glycosyl groups
DT536_RS04645	COG1091	dTDP-4-dehydrorhamnose reductase activity
DT536_RS04660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DT536_RS04670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DT536_RS04675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DT536_RS04680	COG0438	transferase activity, transferring glycosyl groups
DT536_RS04685	COG0438	transferase activity, transferring glycosyl groups
DT536_RS04690	COG0438	transferase activity, transferring glycosyl groups
DT536_RS04715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DT536_RS04745	COG0728	peptidoglycan biosynthetic process
DT536_RS04750	COG3023	N-Acetylmuramoyl-L-alanine amidase
DT536_RS04760	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DT536_RS04770	COG3307	-O-antigen
DT536_RS04775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DT536_RS04780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DT536_RS04785	COG0546	phosphoglycolate phosphatase activity
DT536_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS04810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DT536_RS04810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DT536_RS04815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DT536_RS04820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DT536_RS04825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DT536_RS04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DT536_RS04835	COG1116	anion transmembrane transporter activity
DT536_RS04840	COG1309	transcriptional regulator
DT536_RS04855	COG0196	riboflavin kinase activity
DT536_RS04860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DT536_RS04865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DT536_RS04870	COG1047	Peptidyl-prolyl cis-trans
DT536_RS04885	COG3335	DDE superfamily endonuclease
DT536_RS04895	COG2133	pyrroloquinoline quinone binding
DT536_RS04925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DT536_RS04935	COG0657	acetylesterase activity
DT536_RS05000	COG0488	(ABC) transporter
DT536_RS05010	COG0187	DNA topoisomerase II activity
DT536_RS05020	COG0592	DNA-directed DNA polymerase activity
DT536_RS05025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DT536_RS05040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DT536_RS05045	COG0706	membrane insertase activity
DT536_RS05065	COG1230	cation diffusion facilitator family transporter
DT536_RS05085	COG0402	S-adenosylhomocysteine deaminase activity
DT536_RS05095	COG0754	glutathionylspermidine amidase activity
DT536_RS05105	COG0861	Integral membrane protein TerC family
DT536_RS05125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DT536_RS05140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DT536_RS05145	COG2951	lytic endotransglycosylase activity
DT536_RS05150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DT536_RS05155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DT536_RS05185	COG2814	Major facilitator Superfamily
DT536_RS05195	COG0733	neurotransmitter:sodium symporter activity
DT536_RS05240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DT536_RS05240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DT536_RS05260	COG0129	dihydroxy-acid dehydratase activity
DT536_RS05270	COG4774	siderophore transport
DT536_RS05280	COG0583	DNA-binding transcription factor activity
DT536_RS05285	COG2233	PERMEase
DT536_RS05295	COG1309	transcriptional regulator
DT536_RS05340	COG0436	Aminotransferase
DT536_RS05345	COG1064	alcohol dehydrogenase
DT536_RS05350	COG2818	Glycosylase
DT536_RS05380	COG5487	UPF0391 membrane protein
DT536_RS05385	COG2983	Belongs to the UPF0260 family
DT536_RS05390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DT536_RS05410	COG4160	amino acid transport
DT536_RS05415	COG4215	(ABC) transporter
DT536_RS05435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DT536_RS05440	COG1335	isochorismatase
DT536_RS05445	COG0385	Bile acid
DT536_RS05515	COG0534	Mate efflux family protein
DT536_RS05520	COG0436	Aminotransferase
DT536_RS05525	COG2733	membrane
DT536_RS05540	COG2918	glutathione biosynthetic process
DT536_RS05545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DT536_RS05555	COG3150	esterase
DT536_RS05655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DT536_RS05670	COG1393	Belongs to the ArsC family
DT536_RS05675	COG0708	Exodeoxyribonuclease III
DT536_RS05685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DT536_RS05700	COG1846	Transcriptional regulator
DT536_RS05705	COG0386	Belongs to the glutathione peroxidase family
DT536_RS05710	COG0189	ligase activity
DT536_RS05720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DT536_RS05730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DT536_RS05740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DT536_RS05770	COG2119	membrane
DT536_RS05775	COG0426	domain, Protein
DT536_RS05775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DT536_RS05810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DT536_RS05835	COG1902	pentaerythritol trinitrate reductase activity
DT536_RS05840	COG1519	Transferase
DT536_RS05845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DT536_RS05850	COG0668	transmembrane transport
DT536_RS05855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DT536_RS05860	COG0307	riboflavin synthase, alpha
DT536_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS05880	COG0431	NADPH-dependent FMN reductase
DT536_RS05895	COG2205	protein histidine kinase activity
DT536_RS05895	COG0784	Response regulator, receiver
DT536_RS05900	COG3162	membrane
DT536_RS05915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DT536_RS05925	COG3706	GGDEF domain
DT536_RS05945	COG3335	DDE superfamily endonuclease
DT536_RS05955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DT536_RS05955	COG0352	thiamine-phosphate diphosphorylase activity
DT536_RS05955	COG0351	phosphomethylpyrimidine kinase
DT536_RS05965	COG2814	Major facilitator Superfamily
DT536_RS05970	COG0629	single-stranded DNA binding
DT536_RS06020	COG2132	Multicopper oxidase
DT536_RS06035	COG2205	protein histidine kinase activity
DT536_RS06040	COG3174	membrane
DT536_RS06045	COG2217	Heavy metal translocating P-type atpase
DT536_RS06150	COG0583	DNA-binding transcription factor activity
DT536_RS06155	COG1301	dicarboxylic acid transport
DT536_RS06175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DT536_RS06200	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DT536_RS06245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DT536_RS06275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DT536_RS06280	COG1278	Cold shock
DT536_RS06300	COG0531	amino acid
DT536_RS06305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DT536_RS06340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DT536_RS06375	COG0427	acetyl-CoA hydrolase
DT536_RS06405	COG4221	oxidoreductase activity
DT536_RS06410	COG2873	o-acetylhomoserine
DT536_RS06415	COG0488	(ABC) transporter
DT536_RS06435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DT536_RS06450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DT536_RS06470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DT536_RS06475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DT536_RS06485	COG2226	methyltransferase
DT536_RS06535	COG0070	glutamate synthase
DT536_RS06535	COG0067	glutamate synthase
DT536_RS06535	COG0069	glutamate synthase activity
DT536_RS06540	COG0493	'glutamate synthase
DT536_RS06550	COG1704	LemA family
DT536_RS06555	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DT536_RS06590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DT536_RS06595	COG1758	RNA polymerase activity
DT536_RS06600	COG0194	GDP metabolic process
DT536_RS06610	COG4969	Belongs to the N-Me-Phe pilin family
DT536_RS06645	COG0228	four-way junction DNA binding
DT536_RS06650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DT536_RS06660	COG0335	large ribosomal subunit rRNA binding
DT536_RS06675	COG5380	lipid catabolic process
DT536_RS06680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DT536_RS06700	COG5006	permease, DMT superfamily
DT536_RS06705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DT536_RS06710	COG0277	FAD linked oxidase domain protein
DT536_RS06730	COG2814	Major facilitator Superfamily
DT536_RS06735	COG1289	transmembrane transporter activity
DT536_RS06740	COG2032	superoxide dismutase activity
DT536_RS06745	COG0628	permease
DT536_RS06750	COG1192	Involved in chromosome partitioning
DT536_RS06760	COG2226	methyltransferase
DT536_RS06775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DT536_RS06780	COG0254	rRNA binding
DT536_RS06785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DT536_RS06795	COG0534	Mate efflux family protein
DT536_RS06805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DT536_RS06815	COG1960	acyl-CoA dehydrogenase activity
DT536_RS06835	COG0408	coproporphyrinogen oxidase activity
DT536_RS06840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DT536_RS06860	COG0513	Belongs to the DEAD box helicase family
DT536_RS06865	COG1127	ABC transporter
DT536_RS06870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DT536_RS06875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DT536_RS06880	COG2854	intermembrane phospholipid transfer
DT536_RS06890	COG0598	Magnesium transport protein CorA
DT536_RS06900	COG0494	nUDIX hydrolase
DT536_RS06905	COG1040	competence protein
DT536_RS06910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DT536_RS06935	COG2937	Belongs to the GPAT DAPAT family
DT536_RS06940	COG1946	Acyl-CoA thioesterase
DT536_RS06945	COG1301	dicarboxylic acid transport
DT536_RS06960	COG1959	2 iron, 2 sulfur cluster binding
DT536_RS06970	COG0433	COG0433 Predicted ATPase
DT536_RS06990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DT536_RS06995	COG0088	Forms part of the polypeptide exit tunnel
DT536_RS07010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DT536_RS07060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DT536_RS07065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DT536_RS07075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DT536_RS07100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DT536_RS07115	COG0202	RNA polymerase activity
DT536_RS07120	COG0203	ribosomal protein L17
DT536_RS07125	COG2072	flavoprotein involved in K transport
DT536_RS07140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DT536_RS07170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DT536_RS07175	COG0339	signal peptide processing
DT536_RS07180	COG2720	vancomycin resistance protein
DT536_RS07185	COG0557	exoribonuclease II activity
DT536_RS07215	COG0179	Fumarylacetoacetate (FAA) hydrolase
DT536_RS07230	COG1295	ribonuclease BN
DT536_RS07275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DT536_RS07280	COG1702	phosphate starvation-inducible protein PhoH
DT536_RS07285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DT536_RS07290	COG1196	nuclear chromosome segregation
DT536_RS07290	COG0741	lytic transglycosylase activity
DT536_RS07290	COG0739	heme binding
DT536_RS07300	COG0039	L-malate dehydrogenase activity
DT536_RS07325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DT536_RS07330	COG1183	phosphatidylcholine synthase activity
DT536_RS07390	COG1607	acyl-coa hydrolase
DT536_RS07405	COG1666	GTP binding
DT536_RS07425	COG2350	Protein conserved in bacteria
DT536_RS07435	COG0613	PHP domain protein
DT536_RS07440	COG3781	membrane
DT536_RS07450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DT536_RS07475	COG1162	GTPase activity
DT536_RS07480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DT536_RS07505	COG1538	Outer membrane efflux protein
DT536_RS07510	COG1136	(ABC) transporter
DT536_RS07510	COG0577	efflux transmembrane transporter activity
DT536_RS07515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DT536_RS07540	COG0028	Belongs to the TPP enzyme family
DT536_RS07545	COG0440	acetolactate synthase activity
DT536_RS07605	COG1426	Protein conserved in bacteria
DT536_RS07625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DT536_RS07650	COG1862	Preprotein translocase
DT536_RS07660	COG1704	LemA family
DT536_RS07670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DT536_RS07680	COG5002	protein histidine kinase activity
DT536_RS07685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DT536_RS07735	COG4641	Protein conserved in bacteria
DT536_RS07735	COG0438	transferase activity, transferring glycosyl groups
DT536_RS07750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DT536_RS07780	COG3223	Belongs to the PsiE family
DT536_RS07785	COG1960	acyl-CoA dehydrogenase activity
DT536_RS07790	COG1960	acyl-CoA dehydrogenase activity
DT536_RS07800	COG2205	protein histidine kinase activity
DT536_RS07805	COG0745	RESPONSE REGULATOR receiver
DT536_RS07810	COG1113	amino acid transport
DT536_RS07815	COG2315	Protein conserved in bacteria
DT536_RS07820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DT536_RS07840	COG2096	Adenosyltransferase
DT536_RS07845	COG4206	TonB-dependent receptor
DT536_RS07905	COG0285	dihydrofolate synthase activity
DT536_RS07925	COG0450	alkyl hydroperoxide reductase
DT536_RS07945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DT536_RS07950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DT536_RS07980	COG2199	diguanylate cyclase activity
DT536_RS08040	COG2969	positive regulation of protein catabolic process
DT536_RS08045	COG0625	glutathione transferase activity
DT536_RS08055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DT536_RS08060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DT536_RS08070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DT536_RS08075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DT536_RS08100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DT536_RS08110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DT536_RS08115	COG1408	metallophosphoesterase
DT536_RS08125	COG0477	Major facilitator Superfamily
DT536_RS08130	COG1272	protein, Hemolysin III
DT536_RS08150	COG1250	3-hydroxyacyl-CoA dehydrogenase
DT536_RS08150	COG1024	Enoyl-CoA hydratase
DT536_RS08155	COG0183	Belongs to the thiolase family
DT536_RS08160	COG2207	Transcriptional regulator
DT536_RS08165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DT536_RS08180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DT536_RS08200	COG0183	Belongs to the thiolase family
DT536_RS08215	COG0833	amino acid
DT536_RS08220	COG2813	Specifically methylates the guanine in position
DT536_RS08225	COG2233	PERMEase
DT536_RS08230	COG1217	gtp-binding protein TYPA
DT536_RS08235	COG1970	mechanosensitive ion channel activity
DT536_RS08245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DT536_RS08255	COG3659	wide pore channel activity
DT536_RS08260	COG1902	pentaerythritol trinitrate reductase activity
DT536_RS08295	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DT536_RS08305	COG3293	Transposase
DT536_RS08345	COG0346	lactoylglutathione lyase activity
DT536_RS08350	COG0564	pseudouridine synthase activity
DT536_RS08370	COG3189	MarR family transcriptional regulator
DT536_RS08375	COG2824	Alkylphosphonate utilization operon protein PhnA
DT536_RS08390	COG3422	double-strand break repair
DT536_RS08415	COG0488	(ABC) transporter
DT536_RS08430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DT536_RS08450	COG0730	response to heat
DT536_RS08460	COG1196	nuclear chromosome segregation
DT536_RS08465	COG3115	cell septum assembly
DT536_RS08470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DT536_RS08475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DT536_RS08495	COG2193	ferroxidase activity
DT536_RS08500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DT536_RS08510	COG0596	Alpha beta hydrolase
DT536_RS08510	COG2226	methyltransferase
DT536_RS08510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DT536_RS08525	COG4106	trans-aconitate 2-methyltransferase activity
DT536_RS08555	COG4206	TonB-dependent receptor
DT536_RS08595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DT536_RS08600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DT536_RS08610	COG0009	L-threonylcarbamoyladenylate synthase
DT536_RS08615	COG3101	peptidyl-lysine hydroxylation
DT536_RS08620	COG1399	metal-binding, possibly nucleic acid-binding protein
DT536_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS08645	COG1652	LysM domain
DT536_RS08650	COG1802	Transcriptional regulator
DT536_RS08655	COG0439	Biotin carboxylase
DT536_RS08675	COG3209	COG3209 Rhs family protein
DT536_RS08690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DT536_RS08700	COG0745	RESPONSE REGULATOR receiver
DT536_RS08705	COG2205	protein histidine kinase activity
DT536_RS08715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DT536_RS08735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DT536_RS08750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DT536_RS08760	COG0713	ATP synthesis coupled electron transport
DT536_RS08765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DT536_RS08770	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DT536_RS08785	COG1278	Cold shock
DT536_RS08790	COG1278	Cold shock
DT536_RS08795	COG0583	DNA-binding transcription factor activity
DT536_RS08840	COG0525	valine-tRNA ligase activity
DT536_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS08865	COG0393	Putative heavy-metal-binding
DT536_RS08870	COG1538	Outer membrane efflux protein
DT536_RS08880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DT536_RS08885	COG0671	phosphoesterase, PA-phosphatase related
DT536_RS08905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DT536_RS08920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DT536_RS08930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DT536_RS08935	COG1648	precorrin-2 dehydrogenase activity
DT536_RS08935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DT536_RS08940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DT536_RS08960	COG0531	amino acid
DT536_RS08975	COG0321	lipoyl(octanoyl) transferase activity
DT536_RS08980	COG2921	Belongs to the UPF0250 family
DT536_RS09000	COG1280	lysine exporter protein (LysE YggA)
DT536_RS09015	COG0586	Pfam SNARE associated Golgi protein
DT536_RS09045	COG3335	DDE superfamily endonuclease
DT536_RS09055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DT536_RS09085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DT536_RS09115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DT536_RS09130	COG0358	DNA primase activity
DT536_RS09140	COG0564	pseudouridine synthase activity
DT536_RS09165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DT536_RS09190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DT536_RS09190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DT536_RS09205	COG0300	oxidoreductase activity
DT536_RS09210	COG2072	flavoprotein involved in K transport
DT536_RS09220	COG2009	succinate dehydrogenase
DT536_RS09225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DT536_RS09230	COG1053	succinate dehydrogenase
DT536_RS09235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DT536_RS09250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DT536_RS09260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DT536_RS09270	COG2268	Band 7 protein
DT536_RS09275	COG1585	Membrane protein implicated in regulation of membrane protease activity
DT536_RS09285	COG2354	Protein conserved in bacteria
DT536_RS09290	COG2321	neutral zinc metallopeptidase
DT536_RS09305	COG3695	enzyme binding
DT536_RS09330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DT536_RS09335	COG0505	Belongs to the CarA family
DT536_RS09360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DT536_RS09365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DT536_RS09405	COG2851	Citrate transporter
DT536_RS09410	COG1253	flavin adenine dinucleotide binding
DT536_RS09440	COG2239	Acts as a magnesium transporter
DT536_RS09455	COG0501	Belongs to the peptidase M48B family
DT536_RS09460	COG0741	lytic transglycosylase activity
DT536_RS09465	COG0037	tRNA processing
DT536_RS09475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DT536_RS09480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DT536_RS09520	COG1309	transcriptional regulator
DT536_RS09535	COG1741	Belongs to the pirin family
DT536_RS09555	COG3739	integral membrane protein
DT536_RS09570	COG3706	GGDEF domain
DT536_RS09580	COG0302	gtp cyclohydrolase
DT536_RS09590	COG0300	oxidoreductase activity
DT536_RS09615	COG0134	indole-3-glycerol-phosphate synthase activity
DT536_RS09620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DT536_RS09625	COG0512	Glutamine amidotransferase of anthranilate synthase
DT536_RS09630	COG0174	glutamine synthetase
DT536_RS09640	COG3161	chorismate lyase activity
DT536_RS09645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DT536_RS09685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DT536_RS09690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DT536_RS09695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DT536_RS09700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DT536_RS09715	COG1115	amino acid carrier protein
DT536_RS09720	COG1113	amino acid transport
DT536_RS09730	COG0019	diaminopimelate decarboxylase activity
DT536_RS09740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DT536_RS09750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DT536_RS09755	COG1522	sequence-specific DNA binding
DT536_RS09760	COG1280	lysine exporter protein (LysE YggA)
DT536_RS09795	COG0842	Transport permease protein
DT536_RS09800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DT536_RS09815	COG2175	clavaminate synthase activity
DT536_RS09835	COG0052	Belongs to the universal ribosomal protein uS2 family
DT536_RS09870	COG2951	lytic endotransglycosylase activity
DT536_RS09885	COG0842	Transport permease protein
DT536_RS09890	COG1131	(ABC) transporter
DT536_RS09905	COG0303	'Molybdopterin
DT536_RS09910	COG0521	Mo-molybdopterin cofactor biosynthetic process
DT536_RS09910	COG0315	cyclic pyranopterin monophosphate synthase activity
DT536_RS09940	COG0725	ABC transporter, periplasmic molybdate-binding protein
DT536_RS09945	COG4149	molybdate abc transporter
DT536_RS09965	COG3335	DDE superfamily endonuclease
DT536_RS10015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DT536_RS10040	COG3634	alkyl hydroperoxide reductase activity
DT536_RS10050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DT536_RS10055	COG0826	peptidase U32
DT536_RS10115	COG1720	tRNA m6t6A37 methyltransferase activity
DT536_RS10135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DT536_RS10150	COG0642	Histidine kinase
DT536_RS10160	COG0494	nUDIX hydrolase
DT536_RS10170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DT536_RS10175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DT536_RS10180	COG3139	Protein of unknown function (DUF1315)
DT536_RS10195	COG1301	dicarboxylic acid transport
DT536_RS10200	COG1960	acyl-CoA dehydrogenase activity
DT536_RS10205	COG0693	protein deglycase activity
DT536_RS10215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DT536_RS10220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DT536_RS10250	COG0415	Belongs to the DNA photolyase family
DT536_RS10260	COG2252	PERMEase
DT536_RS10265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DT536_RS10290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DT536_RS10300	COG0527	aspartate kinase activity
DT536_RS10310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DT536_RS10325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DT536_RS10330	COG1522	sequence-specific DNA binding
DT536_RS10345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DT536_RS10360	COG0667	Aldo Keto reductase
DT536_RS10370	COG1765	OsmC-like protein
DT536_RS10395	COG0540	Belongs to the ATCase OTCase family
DT536_RS10415	COG2031	fatty acid transporter
DT536_RS10420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DT536_RS10435	COG4770	biotin carboxylase activity
DT536_RS10445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DT536_RS10450	COG1960	acyl-CoA dehydrogenase activity
DT536_RS10455	COG1309	transcriptional regulator
DT536_RS10460	COG0318	PFAM AMP-dependent synthetase and ligase
DT536_RS10490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DT536_RS10500	COG0659	secondary active sulfate transmembrane transporter activity
DT536_RS10505	COG0625	glutathione transferase activity
DT536_RS10510	COG2249	NAD(P)H dehydrogenase (quinone) activity
DT536_RS10535	COG2363	Small membrane protein
DT536_RS10550	COG1278	Cold shock
DT536_RS10555	COG0513	Belongs to the DEAD box helicase family
DT536_RS10565	COG0778	Nitroreductase
DT536_RS10590	COG0167	dihydroorotate dehydrogenase activity
DT536_RS10620	COG4783	chaperone-mediated protein folding
DT536_RS10625	COG1610	YqeY-like protein
DT536_RS10655	COG2815	serine threonine protein kinase
DT536_RS10655	COG0515	serine threonine protein kinase
DT536_RS10695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DT536_RS10705	COG1643	Atp-dependent helicase
DT536_RS10725	COG1116	anion transmembrane transporter activity
DT536_RS10725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DT536_RS10735	COG2223	nitrite transmembrane transporter activity
DT536_RS10740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DT536_RS10745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DT536_RS10750	COG0243	molybdopterin cofactor binding
DT536_RS10760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DT536_RS10795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DT536_RS10810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DT536_RS10810	COG0517	IMP dehydrogenase activity
DT536_RS10815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DT536_RS10825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DT536_RS10830	COG1137	ATPase activity
DT536_RS10855	COG4122	O-methyltransferase activity
DT536_RS10865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DT536_RS10905	COG2011	ABC-type metal ion transport system permease component
DT536_RS10910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DT536_RS10945	COG0151	Belongs to the GarS family
DT536_RS10950	COG0138	bifunctional purine biosynthesis protein purh
DT536_RS10955	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DT536_RS10985	COG0445	tRNA wobble uridine modification
DT536_RS11000	COG2308	Evidence 4 Homologs of previously reported genes of
DT536_RS11010	COG1305	Transglutaminase-like
DT536_RS11025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DT536_RS11030	COG0305	Participates in initiation and elongation during chromosome replication
DT536_RS11045	COG0360	Binds together with S18 to 16S ribosomal RNA
DT536_RS11065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DT536_RS11070	COG1845	cytochrome c oxidase, subunit III
DT536_RS11075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DT536_RS11080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DT536_RS11110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DT536_RS11125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DT536_RS11130	COG2890	protein-(glutamine-N5) methyltransferase activity
DT536_RS11135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DT536_RS11140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DT536_RS11175	COG1960	acyl-CoA dehydrogenase activity
DT536_RS11180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DT536_RS11195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DT536_RS11220	COG0729	surface antigen
DT536_RS11265	COG4773	Receptor
DT536_RS11270	COG0786	glutamate:sodium symporter activity
DT536_RS11280	COG1113	amino acid transport
DT536_RS11305	COG0024	Methionine aminopeptidase
DT536_RS11310	COG0583	DNA-binding transcription factor activity
DT536_RS11315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DT536_RS11330	COG3852	Histidine kinase
DT536_RS11350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DT536_RS11355	COG0575	Belongs to the CDS family
DT536_RS11370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DT536_RS11390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DT536_RS11415	COG2137	regulation of response to DNA damage stimulus
DT536_RS11420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DT536_RS11425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DT536_RS11430	COG1011	Hydrolase
DT536_RS11470	COG0702	epimerase
DT536_RS11475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DT536_RS11485	COG2267	carboxylic ester hydrolase activity
DT536_RS11495	COG1902	pentaerythritol trinitrate reductase activity
DT536_RS11495	COG0446	pyridine nucleotide-disulphide oxidoreductase
DT536_RS11510	COG2814	Major facilitator Superfamily
DT536_RS11520	COG0583	DNA-binding transcription factor activity
DT536_RS11540	COG0148	phosphopyruvate hydratase activity
DT536_RS11555	COG0772	Belongs to the SEDS family
DT536_RS11570	COG0579	oxidoreductase
DT536_RS11585	COG1012	belongs to the aldehyde dehydrogenase family
DT536_RS11590	COG1309	transcriptional regulator
DT536_RS11595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DT536_RS11610	COG4890	Cyd operon protein YbgT
DT536_RS11615	COG1294	oxidase, subunit
DT536_RS11635	COG1585	Membrane protein implicated in regulation of membrane protease activity
DT536_RS11645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DT536_RS11665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DT536_RS11670	COG0569	domain protein
DT536_RS11680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DT536_RS11685	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DT536_RS11710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DT536_RS11715	COG0542	response to heat
DT536_RS11745	COG0372	Belongs to the citrate synthase family
DT536_RS11755	COG2819	hydrolase of the alpha beta superfamily
DT536_RS11760	COG0318	PFAM AMP-dependent synthetase and ligase
DT536_RS11785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DT536_RS11785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DT536_RS11790	COG1254	Belongs to the acylphosphatase family
DT536_RS11795	COG1047	Peptidyl-prolyl cis-trans
DT536_RS11800	COG1252	NADH dehydrogenase
DT536_RS11805	COG1686	Belongs to the peptidase S11 family
DT536_RS11815	COG2351	hydroxyisourate hydrolase activity
DT536_RS11840	COG1131	(ABC) transporter
DT536_RS11845	COG0842	Transport permease protein
DT536_RS11850	COG0842	Transport permease protein
DT536_RS11875	COG1309	transcriptional regulator
DT536_RS11960	COG1278	Cold shock
DT536_RS12035	COG2070	2-Nitropropane dioxygenase
DT536_RS12060	COG3634	alkyl hydroperoxide reductase activity
DT536_RS12080	COG0436	Aminotransferase
DT536_RS12085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DT536_RS12090	COG0386	Belongs to the glutathione peroxidase family
DT536_RS12115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DT536_RS12130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DT536_RS12155	COG0012	GTP binding
DT536_RS12165	COG2011	ABC-type metal ion transport system permease component
DT536_RS12170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DT536_RS12175	COG1464	Belongs to the NlpA lipoprotein family
DT536_RS12180	COG1464	Belongs to the NlpA lipoprotein family
DT536_RS12220	COG0204	Acyl-transferase
DT536_RS12255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DT536_RS12260	COG0730	response to heat
DT536_RS12285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DT536_RS12290	COG1944	ATP diphosphatase activity
DT536_RS12295	COG2207	Transcriptional regulator
DT536_RS12300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DT536_RS12305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DT536_RS12335	COG2223	nitrite transmembrane transporter activity
DT536_RS12350	COG1346	cytolysis
DT536_RS12355	COG1380	Effector of murein hydrolase LrgA
DT536_RS12360	COG0583	DNA-binding transcription factor activity
DT536_RS12415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DT536_RS12530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DT536_RS12540	COG3300	MHYT domain
DT536_RS12540	COG5001	Diguanylate cyclase
DT536_RS12545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DT536_RS12555	COG2814	Major facilitator Superfamily
DT536_RS12570	COG1132	(ABC) transporter
DT536_RS12580	COG0668	transmembrane transport
DT536_RS12585	COG3122	Protein conserved in bacteria
DT536_RS12605	COG0640	Transcriptional regulator
DT536_RS12610	COG0596	Alpha beta hydrolase
DT536_RS12615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DT536_RS12620	COG1335	isochorismatase
DT536_RS12625	COG0251	oxidation-reduction process
DT536_RS12630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DT536_RS12635	COG2233	PERMEase
DT536_RS12645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DT536_RS12655	COG0183	Belongs to the thiolase family
DT536_RS12660	COG0583	DNA-binding transcription factor activity
DT536_RS12675	COG0439	Biotin carboxylase
DT536_RS12690	COG0511	ligase activity, forming carbon-carbon bonds
DT536_RS12710	COG4829	muconolactone delta-isomerase
DT536_RS12715	COG4948	Mandelate Racemase Muconate Lactonizing
DT536_RS12720	COG0583	DNA-binding transcription factor activity
DT536_RS12725	COG2814	Major facilitator Superfamily
DT536_RS12830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DT536_RS12835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DT536_RS12840	COG0022	dehydrogenase e1 component
DT536_RS12845	COG0508	dehydrogenase complex catalyzes the overall conversion of
DT536_RS12850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DT536_RS12860	COG1063	alcohol dehydrogenase
DT536_RS12865	COG4628	conserved protein (DUF2132)
DT536_RS13065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DT536_RS13070	COG1129	ABC transporter
DT536_RS13070	COG0842	Transport permease protein
DT536_RS13075	COG0842	Transport permease protein
DT536_RS13080	COG1283	sodium-dependent phosphate transmembrane transporter activity
DT536_RS13180	COG2814	Major facilitator Superfamily
DT536_RS13255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DT536_RS13260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DT536_RS13280	COG2801	Transposase and inactivated derivatives
DT536_RS13450	COG0596	Alpha beta hydrolase
DT536_RS13520	COG0864	Transcriptional regulator
DT536_RS13545	COG2814	Major facilitator Superfamily
DT536_RS13555	COG2199	diguanylate cyclase activity
DT536_RS13600	COG1960	acyl-CoA dehydrogenase activity
DT536_RS13605	COG1960	acyl-CoA dehydrogenase activity
DT536_RS13655	COG0552	protein localization to endoplasmic reticulum
DT536_RS13660	COG0612	Peptidase, M16
DT536_RS13690	COG0517	IMP dehydrogenase activity
DT536_RS13695	COG0133	tryptophan synthase activity
DT536_RS13705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DT536_RS13720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DT536_RS13725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DT536_RS13765	COG0537	adenosine 5'-monophosphoramidase activity
DT536_RS13790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DT536_RS13795	COG0776	regulation of translation
DT536_RS13810	COG1959	2 iron, 2 sulfur cluster binding
DT536_RS13820	COG0822	iron-sulfur transferase activity
DT536_RS13825	COG0316	Belongs to the HesB IscA family
DT536_RS13855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DT536_RS13870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DT536_RS13880	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DT536_RS13880	COG0506	proline dehydrogenase activity
DT536_RS13880	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DT536_RS13915	COG3781	membrane
DT536_RS13920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DT536_RS13930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DT536_RS13950	COG0697	spore germination
DT536_RS13965	COG0126	phosphoglycerate kinase activity
DT536_RS13975	COG0424	maF-like protein
DT536_RS13985	COG2850	peptidyl-arginine hydroxylation
DT536_RS13990	COG4585	Histidine kinase
DT536_RS13995	COG2197	response regulator
DT536_RS14000	COG0069	glutamate synthase activity
DT536_RS14020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DT536_RS14025	COG1454	alcohol dehydrogenase
DT536_RS14030	COG0824	Thioesterase
DT536_RS14035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DT536_RS14055	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS14060	COG0183	Belongs to the thiolase family
DT536_RS14080	COG0583	DNA-binding transcription factor activity
DT536_RS14085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DT536_RS14095	COG3135	benzoate transporter
DT536_RS14100	COG1309	transcriptional regulator
DT536_RS14105	COG2076	Multidrug Resistance protein
DT536_RS14120	COG0589	response to stress
DT536_RS14130	COG0308	aminopeptidase N
DT536_RS14155	COG1253	flavin adenine dinucleotide binding
DT536_RS14175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DT536_RS14180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DT536_RS14195	COG2431	L-lysine efflux transmembrane transporter activity
DT536_RS14210	COG0776	regulation of translation
DT536_RS14230	COG0590	tRNA wobble adenosine to inosine editing
DT536_RS14240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DT536_RS14275	COG0084	hydrolase, TatD family'
DT536_RS14295	COG1663	tetraacyldisaccharide 4'-kinase activity
DT536_RS14300	COG1132	(ABC) transporter
DT536_RS14310	COG0811	peptide transport
DT536_RS14315	COG1475	DNA binding
DT536_RS14320	COG1192	Involved in chromosome partitioning
DT536_RS14330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DT536_RS14345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DT536_RS14350	COG1923	regulation of RNA biosynthetic process
DT536_RS14360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DT536_RS14365	COG0802	atpase or kinase
DT536_RS14370	COG0564	pseudouridine synthase activity
DT536_RS14385	COG1187	pseudouridine synthase activity
DT536_RS14390	COG2707	UPF0756 membrane protein
DT536_RS14395	COG2814	Major facilitator Superfamily
DT536_RS14400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DT536_RS14405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DT536_RS14415	COG1454	alcohol dehydrogenase
DT536_RS14435	COG0531	amino acid
DT536_RS14440	COG4303	Ethanolamine ammonia lyase large subunit
DT536_RS14445	COG4302	ethanolamine ammonia-lyase activity
DT536_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
DT536_RS14465	COG0519	Catalyzes the synthesis of GMP from XMP
DT536_RS14465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DT536_RS14475	COG0456	acetyltransferase
DT536_RS14485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DT536_RS14490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DT536_RS14535	COG0352	thiamine-phosphate diphosphorylase activity
DT536_RS14570	COG0612	Peptidase, M16
DT536_RS14580	COG1823	symporter activity
DT536_RS14585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DT536_RS14605	COG0582	viral genome integration into host DNA
DT536_RS14640	COG1570	exodeoxyribonuclease VII activity
DT536_RS14655	COG1877	trehalose-phosphatase activity
DT536_RS14660	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DT536_RS14665	COG2223	nitrite transmembrane transporter activity
DT536_RS14710	COG2323	membrane
DT536_RS14725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DT536_RS14745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DT536_RS14880	COG0714	Associated with various cellular activities
DT536_RS14885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DT536_RS14890	COG2879	small protein
DT536_RS14895	COG1966	Carbon starvation protein
DT536_RS14900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DT536_RS14920	COG0254	rRNA binding
DT536_RS14940	COG1067	ATP-dependent peptidase activity
DT536_RS14945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DT536_RS14950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DT536_RS14955	COG0616	signal peptide processing
DT536_RS14960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DT536_RS14970	COG0573	inorganic phosphate transmembrane transporter activity
DT536_RS14975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DT536_RS14980	COG0076	glutamate decarboxylase activity
DT536_RS14985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DT536_RS15000	COG0671	phosphoesterase, PA-phosphatase related
DT536_RS15005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DT536_RS15015	COG1733	regulation of RNA biosynthetic process
DT536_RS15020	COG0702	epimerase
DT536_RS15035	COG3335	DDE superfamily endonuclease
DT536_RS15060	COG0556	nucleotide-excision repair
DT536_RS15075	COG2199	diguanylate cyclase activity
DT536_RS15085	COG0436	Aminotransferase
DT536_RS15120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DT536_RS15125	COG1381	Involved in DNA repair and RecF pathway recombination
DT536_RS15135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DT536_RS15140	COG0571	ribonuclease III activity
DT536_RS15150	COG0681	Belongs to the peptidase S26 family
DT536_RS15180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DT536_RS15200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DT536_RS15210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DT536_RS15225	COG4208	sulfate ABC transporter
DT536_RS15230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DT536_RS15235	COG0583	DNA-binding transcription factor activity
DT536_RS15255	COG0602	queuosine metabolic process
DT536_RS15260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DT536_RS15275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DT536_RS15285	COG0583	DNA-binding transcription factor activity
DT536_RS15290	COG2353	YceI-like domain
DT536_RS15295	COG1051	belongs to the nudix hydrolase family
DT536_RS15295	COG1056	cytidyltransferase-related domain
DT536_RS15300	COG1024	Enoyl-CoA hydratase
DT536_RS15305	COG0778	Nitroreductase
DT536_RS15320	COG3323	Protein of unknown function (DUF1653)
DT536_RS15320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DT536_RS15330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DT536_RS15330	COG0047	phosphoribosylformylglycinamidine synthase activity
DT536_RS15340	COG0632	four-way junction helicase activity
DT536_RS15345	COG2255	four-way junction helicase activity
DT536_RS15360	COG0824	Thioesterase
DT536_RS15380	COG0823	Involved in the tonB-independent uptake of proteins
DT536_RS15400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DT536_RS15435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DT536_RS15440	COG0628	permease
DT536_RS15445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DT536_RS15450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DT536_RS15470	COG0658	competence protein
DT536_RS15470	COG2333	competence protein COMEC
DT536_RS15475	COG1136	(ABC) transporter
DT536_RS15480	COG4591	ABC-type transport system involved in lipoprotein release permease component
DT536_RS15495	COG1671	Belongs to the UPF0178 family
DT536_RS15505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DT536_RS15510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DT536_RS15560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DT536_RS15565	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DT536_RS15570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DT536_RS15580	COG0281	malic enzyme
DT536_RS15580	COG0280	phosphate acetyltransferase
DT536_RS15610	COG1902	pentaerythritol trinitrate reductase activity
DT536_RS15610	COG0446	pyridine nucleotide-disulphide oxidoreductase
DT536_RS15615	COG0277	FAD linked oxidase domain protein
DT536_RS15625	COG2186	Transcriptional regulator
DT536_RS15640	COG4251	negative regulation of phosphorylation
DT536_RS15640	COG3706	GGDEF domain
DT536_RS15640	COG2203	Gaf domain
DT536_RS15640	COG5001	Diguanylate cyclase
DT536_RS15645	COG0418	dihydroorotase activity
DT536_RS15650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DT536_RS15670	COG0833	amino acid
DT536_RS15695	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DT536_RS15710	COG4172	Belongs to the ABC transporter superfamily
DT536_RS15715	COG4239	(ABC) transporter, permease
DT536_RS15720	COG4174	ABC transporter (Permease)
DT536_RS15725	COG4166	transmembrane transport
DT536_RS15730	COG0741	lytic transglycosylase activity
DT536_RS15730	COG1388	LysM domain
DT536_RS15735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DT536_RS15745	COG2816	NAD+ diphosphatase activity
DT536_RS15750	COG0657	acetylesterase activity
DT536_RS15770	COG0583	DNA-binding transcription factor activity
DT536_RS15790	COG0753	catalase activity
DT536_RS15810	COG1686	Belongs to the peptidase S11 family
DT536_RS15815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DT536_RS15820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DT536_RS15825	COG2267	carboxylic ester hydrolase activity
DT536_RS15830	COG2453	phosphatase
DT536_RS15830	COG0671	phosphoesterase, PA-phosphatase related
DT536_RS15845	COG4589	Belongs to the CDS family
DT536_RS15860	COG2915	High frequency lysogenization protein hflD homolog
DT536_RS15880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DT536_RS15885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DT536_RS15900	COG0006	proline dipeptidase activity
DT536_RS15970	COG1785	Belongs to the alkaline phosphatase family
DT536_RS15975	COG1785	Belongs to the alkaline phosphatase family
DT536_RS15990	COG4770	biotin carboxylase activity
DT536_RS16010	COG1914	H( )-stimulated, divalent metal cation uptake system
DT536_RS16015	COG0583	DNA-binding transcription factor activity
DT536_RS16020	COG2217	Heavy metal translocating P-type atpase
DT536_RS16030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DT536_RS16045	COG2234	aminopeptidase activity
DT536_RS16055	COG3384	dioxygenase
DT536_RS16065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DT536_RS16070	COG2878	Part of a membrane complex involved in electron transport
DT536_RS16080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DT536_RS16105	COG0768	penicillin binding
DT536_RS16110	COG0742	ribosomal rna small subunit methyltransferase
DT536_RS16205	COG1597	lipid kinase activity
DT536_RS16225	COG0477	Major facilitator Superfamily
DT536_RS16265	COG4221	oxidoreductase activity
DT536_RS16265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DT536_RS16265	COG0604	alcohol dehydrogenase
DT536_RS16265	COG3321	synthase
DT536_RS16280	COG1695	Transcriptional regulator
DT536_RS16315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DT536_RS16320	COG1773	rubredoxin
DT536_RS16325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DT536_RS16335	COG0583	DNA-binding transcription factor activity
DT536_RS16355	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DT536_RS16360	COG4181	ATPase activity
DT536_RS16405	COG0306	phosphate transporter
DT536_RS16415	COG2223	nitrite transmembrane transporter activity
DT536_RS16420	COG2207	Transcriptional regulator
DT536_RS16425	COG0242	peptide deformylase activity
DT536_RS16430	COG0477	Major facilitator Superfamily
DT536_RS16475	COG2199	diguanylate cyclase activity
DT536_RS16475	COG2203	Gaf domain
DT536_RS16485	COG4681	YaeQ
DT536_RS16490	COG0523	cobalamin synthesis protein
DT536_RS16500	COG1607	acyl-coa hydrolase
DT536_RS16505	COG1752	Esterase of the alpha-beta hydrolase superfamily
DT536_RS16515	COG1115	amino acid carrier protein
DT536_RS16520	COG0786	glutamate:sodium symporter activity
DT536_RS16530	COG2814	Major facilitator Superfamily