locus-tag	class	description
E0Z08_RS00010	COG0592	DNA-directed DNA polymerase activity
E0Z08_RS00020	COG0187	DNA topoisomerase II activity
E0Z08_RS00035	COG2951	lytic endotransglycosylase activity
E0Z08_RS00040	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E0Z08_RS00045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E0Z08_RS00075	COG2133	pyrroloquinoline quinone binding
E0Z08_RS00090	COG1047	Peptidyl-prolyl cis-trans
E0Z08_RS00095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E0Z08_RS00100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E0Z08_RS00105	COG0196	riboflavin kinase activity
E0Z08_RS00120	COG1309	transcriptional regulator
E0Z08_RS00125	COG1116	anion transmembrane transporter activity
E0Z08_RS00130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0Z08_RS00135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0Z08_RS00140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0Z08_RS00145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0Z08_RS00150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0Z08_RS00150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E0Z08_RS00170	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS00175	COG0546	phosphoglycolate phosphatase activity
E0Z08_RS00180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0Z08_RS00185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0Z08_RS00190	COG3385	transposase activity
E0Z08_RS00195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E0Z08_RS00205	COG3307	-O-antigen
E0Z08_RS00210	COG3385	transposase activity
E0Z08_RS00220	COG3023	N-Acetylmuramoyl-L-alanine amidase
E0Z08_RS00225	COG0728	peptidoglycan biosynthetic process
E0Z08_RS00255	COG1596	polysaccharide export
E0Z08_RS00260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0Z08_RS00275	COG5039	Polysaccharide pyruvyl transferase
E0Z08_RS00280	COG1442	glycosyl transferase family 8
E0Z08_RS00280	COG1216	Glycosyl transferase, family 2
E0Z08_RS00285	COG0438	transferase activity, transferring glycosyl groups
E0Z08_RS00295	COG0463	Glycosyl transferase, family 2
E0Z08_RS00305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E0Z08_RS00315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E0Z08_RS00325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E0Z08_RS00340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E0Z08_RS00345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0Z08_RS00385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E0Z08_RS00395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E0Z08_RS00400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E0Z08_RS00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E0Z08_RS00425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E0Z08_RS00430	COG0583	DNA-binding transcription factor activity
E0Z08_RS00435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0Z08_RS00435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0Z08_RS00440	COG1105	Belongs to the carbohydrate kinase PfkB family
E0Z08_RS00445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0Z08_RS00445	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E0Z08_RS00445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0Z08_RS00450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E0Z08_RS00505	COG0271	Belongs to the BolA IbaG family
E0Z08_RS00515	COG1192	Involved in chromosome partitioning
E0Z08_RS00530	COG0586	Pfam SNARE associated Golgi protein
E0Z08_RS00545	COG0519	Catalyzes the synthesis of GMP from XMP
E0Z08_RS00545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E0Z08_RS00595	COG0281	malic enzyme
E0Z08_RS00605	COG3409	Peptidoglycan-binding domain 1 protein
E0Z08_RS00605	COG1388	LysM domain
E0Z08_RS00605	COG5632	N-Acetylmuramoyl-L-alanine amidase
E0Z08_RS00615	COG2837	iron assimilation
E0Z08_RS00625	COG1683	Conserved Protein
E0Z08_RS00630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E0Z08_RS00635	COG1121	(ABC) transporter
E0Z08_RS00685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E0Z08_RS00720	COG0386	Belongs to the glutathione peroxidase family
E0Z08_RS00730	COG0697	spore germination
E0Z08_RS00740	COG0758	DNA mediated transformation
E0Z08_RS00820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0Z08_RS00830	COG2814	Major facilitator Superfamily
E0Z08_RS00850	COG1253	flavin adenine dinucleotide binding
E0Z08_RS00855	COG3012	SEC-C Motif Domain Protein
E0Z08_RS00860	COG2860	membrane
E0Z08_RS00865	COG0477	Major facilitator Superfamily
E0Z08_RS00875	COG0318	PFAM AMP-dependent synthetase and ligase
E0Z08_RS00890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E0Z08_RS00910	COG0606	chelatase, subunit chli
E0Z08_RS00965	COG0633	Ferredoxin
E0Z08_RS01005	COG2814	Major facilitator Superfamily
E0Z08_RS01045	COG0789	Transcriptional regulator
E0Z08_RS01055	COG0640	Transcriptional regulator
E0Z08_RS01065	COG1230	cation diffusion facilitator family transporter
E0Z08_RS01070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z08_RS01160	COG0347	Belongs to the P(II) protein family
E0Z08_RS01165	COG0004	ammonium transporteR
E0Z08_RS01175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0Z08_RS01175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0Z08_RS01190	COG0586	Pfam SNARE associated Golgi protein
E0Z08_RS01210	COG0795	lipopolysaccharide-transporting ATPase activity
E0Z08_RS01215	COG0795	lipopolysaccharide-transporting ATPase activity
E0Z08_RS01220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E0Z08_RS01225	COG0793	Belongs to the peptidase S41A family
E0Z08_RS01240	COG2197	response regulator
E0Z08_RS01245	COG1686	Belongs to the peptidase S11 family
E0Z08_RS01250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E0Z08_RS01260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0Z08_RS01265	COG4974	Belongs to the 'phage' integrase family
E0Z08_RS01285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E0Z08_RS01290	COG0772	Belongs to the SEDS family
E0Z08_RS01295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0Z08_RS01300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E0Z08_RS01305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E0Z08_RS01325	COG1538	Outer membrane efflux protein
E0Z08_RS01345	COG3275	phosphorelay sensor kinase activity
E0Z08_RS01355	COG0181	hydroxymethylbilane synthase activity
E0Z08_RS01375	COG0824	Thioesterase
E0Z08_RS01405	COG0546	phosphoglycolate phosphatase activity
E0Z08_RS01455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E0Z08_RS01460	COG0081	regulation of translation
E0Z08_RS01465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E0Z08_RS01470	COG0222	ribosome binding
E0Z08_RS01475	COG0085	RNA polymerase activity
E0Z08_RS01480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E0Z08_RS01515	COG2056	Na+-H+ antiporter family
E0Z08_RS01520	COG3047	cAMP biosynthetic process
E0Z08_RS01530	COG0326	Molecular chaperone. Has ATPase activity
E0Z08_RS01560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E0Z08_RS01630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E0Z08_RS01635	COG1132	(ABC) transporter
E0Z08_RS01650	COG1289	transmembrane transporter activity
E0Z08_RS01670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E0Z08_RS01680	COG0497	DNA recombination
E0Z08_RS01690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0Z08_RS01700	COG0237	dephospho-CoA kinase activity
E0Z08_RS01755	COG0195	Participates in both transcription termination and antitermination
E0Z08_RS01765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E0Z08_RS01770	COG1320	monovalent cation:proton antiporter activity
E0Z08_RS01775	COG2212	antiporter activity
E0Z08_RS01780	COG1863	multisubunit Na H antiporter MnhE subunit
E0Z08_RS01785	COG0651	ATP synthesis coupled electron transport
E0Z08_RS01790	COG1006	Multisubunit Na H antiporter MnhC subunit
E0Z08_RS01795	COG2111	Na H antiporter
E0Z08_RS01795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0Z08_RS01800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E0Z08_RS01810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E0Z08_RS01825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E0Z08_RS01855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E0Z08_RS01860	COG1074	ATP-dependent DNA helicase activity
E0Z08_RS01865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0Z08_RS01870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0Z08_RS01880	COG1185	polyribonucleotide nucleotidyltransferase activity
E0Z08_RS01885	COG0598	Magnesium transport protein CorA
E0Z08_RS01890	COG2841	Protein conserved in bacteria
E0Z08_RS01910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E0Z08_RS01920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E0Z08_RS01940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0Z08_RS01945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E0Z08_RS01950	COG4535	Mg2 and Co2 transporter CorC
E0Z08_RS01955	COG0425	Belongs to the sulfur carrier protein TusA family
E0Z08_RS01980	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E0Z08_RS01980	COG0644	oxidoreductase
E0Z08_RS01990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E0Z08_RS02000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E0Z08_RS02005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0Z08_RS02015	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E0Z08_RS02025	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0Z08_RS02025	COG0493	'glutamate synthase
E0Z08_RS02040	COG2226	methyltransferase
E0Z08_RS02055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E0Z08_RS02080	COG0751	glycine-tRNA ligase activity
E0Z08_RS02100	COG1983	PspC domain protein
E0Z08_RS02125	COG0318	PFAM AMP-dependent synthetase and ligase
E0Z08_RS02130	COG1530	ribonuclease E activity
E0Z08_RS02140	COG0564	pseudouridine synthase activity
E0Z08_RS02155	COG0583	DNA-binding transcription factor activity
E0Z08_RS02170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E0Z08_RS02190	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS02205	COG1280	lysine exporter protein (LysE YggA)
E0Z08_RS02240	COG0583	DNA-binding transcription factor activity
E0Z08_RS02250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E0Z08_RS02265	COG0473	3-isopropylmalate dehydrogenase activity
E0Z08_RS02325	COG1560	Kdo2-lipid A biosynthetic process
E0Z08_RS02330	COG0488	(ABC) transporter
E0Z08_RS02335	COG2900	Belongs to the SlyX family
E0Z08_RS02380	COG0210	DNA helicase
E0Z08_RS02405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0Z08_RS02405	COG4651	solute:proton antiporter activity
E0Z08_RS02430	COG0788	formyltetrahydrofolate deformylase activity
E0Z08_RS02535	COG2813	Specifically methylates the guanine in position
E0Z08_RS02535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0Z08_RS02545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0Z08_RS02560	COG4774	siderophore transport
E0Z08_RS02565	COG4771	TonB-dependent receptor
E0Z08_RS02575	COG0740	serine-type endopeptidase activity
E0Z08_RS02595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E0Z08_RS02595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E0Z08_RS02605	COG2207	Transcriptional regulator
E0Z08_RS02605	COG1917	Cupin 2, conserved barrel domain protein
E0Z08_RS02615	COG2318	DinB family
E0Z08_RS02625	COG0857	belongs to the CobB CobQ family
E0Z08_RS02625	COG0280	phosphate acetyltransferase
E0Z08_RS02630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E0Z08_RS02640	COG2267	carboxylic ester hydrolase activity
E0Z08_RS02655	COG0793	Belongs to the peptidase S41A family
E0Z08_RS02670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E0Z08_RS02685	COG0084	hydrolase, TatD family'
E0Z08_RS02695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E0Z08_RS02710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0Z08_RS02750	COG2207	Transcriptional regulator
E0Z08_RS02800	COG0640	Transcriptional regulator
E0Z08_RS02810	COG0798	PFAM Bile acid sodium symporter
E0Z08_RS02815	COG0431	NADPH-dependent FMN reductase
E0Z08_RS02820	COG0492	ferredoxin-NADP+ reductase activity
E0Z08_RS02845	COG1294	oxidase, subunit
E0Z08_RS02850	COG1271	oxidase subunit
E0Z08_RS02880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E0Z08_RS02885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E0Z08_RS02895	COG2205	protein histidine kinase activity
E0Z08_RS02900	COG0745	RESPONSE REGULATOR receiver
E0Z08_RS02905	COG0174	glutamine synthetase
E0Z08_RS02930	COG2814	Major facilitator Superfamily
E0Z08_RS02960	COG0675	Transposase, IS605 OrfB family
E0Z08_RS02965	COG0004	ammonium transporteR
E0Z08_RS02985	COG3622	Belongs to the hyi family
E0Z08_RS02990	COG2084	Dehydrogenase
E0Z08_RS02995	COG1024	Enoyl-CoA hydratase
E0Z08_RS03000	COG0784	Response regulator, receiver
E0Z08_RS03000	COG2205	protein histidine kinase activity
E0Z08_RS03000	COG5002	protein histidine kinase activity
E0Z08_RS03005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E0Z08_RS03020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0Z08_RS03030	COG3956	TIGRFAM MazG family protein
E0Z08_RS03035	COG1555	photosystem II stabilization
E0Z08_RS03040	COG0617	tRNA 3'-terminal CCA addition
E0Z08_RS03045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E0Z08_RS03055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E0Z08_RS03060	COG1660	Displays ATPase and GTPase activities
E0Z08_RS03070	COG3028	Belongs to the UPF0307 family
E0Z08_RS03075	COG0318	PFAM AMP-dependent synthetase and ligase
E0Z08_RS03095	COG0625	glutathione transferase activity
E0Z08_RS03110	COG1238	metal cluster binding
E0Z08_RS03155	COG0072	phenylalanine-tRNA ligase activity
E0Z08_RS03180	COG0248	Ppx GppA phosphatase
E0Z08_RS03190	COG0037	tRNA processing
E0Z08_RS03205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0Z08_RS03205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0Z08_RS03235	COG1764	response to oxidative stress
E0Z08_RS03240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0Z08_RS03250	COG2208	phosphoserine phosphatase activity
E0Z08_RS03255	COG2853	Lipoprotein
E0Z08_RS03285	COG2814	Major facilitator Superfamily
E0Z08_RS03300	COG0693	protein deglycase activity
E0Z08_RS03325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E0Z08_RS03335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E0Z08_RS03385	COG0494	nUDIX hydrolase
E0Z08_RS03390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E0Z08_RS03395	COG1214	PFAM Peptidase M22, glycoprotease
E0Z08_RS03400	COG1968	undecaprenyl-diphosphatase activity
E0Z08_RS03435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0Z08_RS03445	COG2132	Multicopper oxidase
E0Z08_RS03470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0Z08_RS03480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E0Z08_RS03480	COG0352	thiamine-phosphate diphosphorylase activity
E0Z08_RS03480	COG0351	phosphomethylpyrimidine kinase
E0Z08_RS03510	COG0251	oxidation-reduction process
E0Z08_RS03515	COG1113	amino acid transport
E0Z08_RS03525	COG1981	membrane
E0Z08_RS03540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E0Z08_RS03565	COG0456	acetyltransferase
E0Z08_RS03575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E0Z08_RS03580	COG0492	ferredoxin-NADP+ reductase activity
E0Z08_RS03585	COG1674	ftsk spoiiie
E0Z08_RS03585	COG0531	amino acid
E0Z08_RS03600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E0Z08_RS03610	COG0850	regulation of cytokinetic process
E0Z08_RS03620	COG0204	Acyl-transferase
E0Z08_RS03625	COG2885	chlorophyll binding
E0Z08_RS03630	COG0210	DNA helicase
E0Z08_RS03635	COG0756	dUTP diphosphatase activity
E0Z08_RS03650	COG0121	glutamine amidotransferase
E0Z08_RS03655	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS03665	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E0Z08_RS03670	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS03685	COG2914	Belongs to the UPF0125 (RnfH) family
E0Z08_RS03690	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0Z08_RS03695	COG0735	belongs to the Fur family
E0Z08_RS03725	COG0420	3'-5' exonuclease activity
E0Z08_RS03730	COG5001	Diguanylate cyclase
E0Z08_RS03730	COG4251	negative regulation of phosphorylation
E0Z08_RS03730	COG3706	GGDEF domain
E0Z08_RS03730	COG2203	Gaf domain
E0Z08_RS03740	COG1090	epimerase
E0Z08_RS03755	COG2050	protein possibly involved in aromatic compounds catabolism
E0Z08_RS03760	COG1566	PFAM secretion protein HlyD family protein
E0Z08_RS03765	COG2814	Major facilitator Superfamily
E0Z08_RS03770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E0Z08_RS03855	COG3046	protein related to deoxyribodipyrimidine photolyase
E0Z08_RS03860	COG2816	NAD+ diphosphatase activity
E0Z08_RS03885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E0Z08_RS03900	COG0642	Histidine kinase
E0Z08_RS03935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E0Z08_RS03945	COG3177	Filamentation induced by cAMP protein fic
E0Z08_RS03965	COG4221	oxidoreductase activity
E0Z08_RS03970	COG0583	DNA-binding transcription factor activity
E0Z08_RS03975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E0Z08_RS03980	COG3321	synthase
E0Z08_RS03980	COG0604	alcohol dehydrogenase
E0Z08_RS03995	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E0Z08_RS04010	COG1979	alcohol dehydrogenase
E0Z08_RS04020	COG1902	pentaerythritol trinitrate reductase activity
E0Z08_RS04030	COG1309	transcriptional regulator
E0Z08_RS04035	COG2130	NADP-dependent
E0Z08_RS04065	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS04110	COG1522	sequence-specific DNA binding
E0Z08_RS04120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0Z08_RS04130	COG1346	cytolysis
E0Z08_RS04140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0Z08_RS04150	COG1294	oxidase, subunit
E0Z08_RS04155	COG1271	oxidase subunit
E0Z08_RS04170	COG1113	amino acid transport
E0Z08_RS04180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E0Z08_RS04185	COG1012	belongs to the aldehyde dehydrogenase family
E0Z08_RS04200	COG1522	sequence-specific DNA binding
E0Z08_RS04205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E0Z08_RS04215	COG3138	arginine N-succinyltransferase
E0Z08_RS04220	COG1012	belongs to the aldehyde dehydrogenase family
E0Z08_RS04225	COG3724	N-succinylarginine dihydrolase activity
E0Z08_RS04260	COG1414	Transcriptional regulator
E0Z08_RS04265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E0Z08_RS04270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0Z08_RS04275	COG0183	Belongs to the thiolase family
E0Z08_RS04280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E0Z08_RS04285	COG0596	Alpha beta hydrolase
E0Z08_RS04290	COG2271	Major facilitator Superfamily
E0Z08_RS04295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0Z08_RS04300	COG3485	protocatechuate 3,4-dioxygenase
E0Z08_RS04305	COG3485	protocatechuate 3,4-dioxygenase
E0Z08_RS04310	COG0710	3-dehydroquinate dehydratase activity
E0Z08_RS04315	COG3420	alginic acid biosynthetic process
E0Z08_RS04320	COG3659	wide pore channel activity
E0Z08_RS04325	COG4993	Dehydrogenase
E0Z08_RS04330	COG4772	TonB-dependent receptor
E0Z08_RS04340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0Z08_RS04350	COG0583	DNA-binding transcription factor activity
E0Z08_RS04355	COG2610	gluconate transmembrane transporter activity
E0Z08_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS04370	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E0Z08_RS04415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E0Z08_RS04425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E0Z08_RS04430	COG1077	Cell shape determining protein MreB Mrl
E0Z08_RS04435	COG1792	Involved in formation and maintenance of cell shape
E0Z08_RS04440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E0Z08_RS04445	COG0424	maF-like protein
E0Z08_RS04455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E0Z08_RS04510	COG0640	Transcriptional regulator
E0Z08_RS04520	COG0798	PFAM Bile acid sodium symporter
E0Z08_RS04525	COG0431	NADPH-dependent FMN reductase
E0Z08_RS04530	COG2072	flavoprotein involved in K transport
E0Z08_RS04540	COG0625	glutathione transferase activity
E0Z08_RS04555	COG1448	Aminotransferase
E0Z08_RS04560	COG1113	amino acid transport
E0Z08_RS04635	COG4197	protein conserved in bacteria, prophage-related
E0Z08_RS04830	COG0582	viral genome integration into host DNA
E0Z08_RS04840	COG1113	amino acid transport
E0Z08_RS04845	COG2828	Protein conserved in bacteria
E0Z08_RS04850	COG0142	geranyltranstransferase activity
E0Z08_RS04865	COG1752	Esterase of the alpha-beta hydrolase superfamily
E0Z08_RS04890	COG0745	RESPONSE REGULATOR receiver
E0Z08_RS04895	COG0642	Histidine kinase
E0Z08_RS04910	COG0004	ammonium transporteR
E0Z08_RS04920	COG1126	abc transporter atp-binding protein
E0Z08_RS04925	COG0765	amino acid transport
E0Z08_RS04930	COG0765	amino acid transport
E0Z08_RS04950	COG0668	transmembrane transport
E0Z08_RS04960	COG2081	HI0933 family
E0Z08_RS04965	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E0Z08_RS04995	COG4716	Myosin-crossreactive antigen
E0Z08_RS05030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0Z08_RS05030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0Z08_RS05055	COG0489	protein tyrosine kinase activity
E0Z08_RS05070	COG2358	TRAP transporter, solute receptor (TAXI family
E0Z08_RS05140	COG0840	transmembrane signaling receptor activity
E0Z08_RS05145	COG2198	Histidine kinase
E0Z08_RS05145	COG0784	Response regulator, receiver
E0Z08_RS05145	COG0643	Histidine kinase
E0Z08_RS05155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E0Z08_RS05170	COG2832	Protein of unknown function (DUF454)
E0Z08_RS05240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E0Z08_RS05250	COG1289	transmembrane transporter activity
E0Z08_RS05255	COG2814	Major facilitator Superfamily
E0Z08_RS05275	COG0786	glutamate:sodium symporter activity
E0Z08_RS05280	COG1115	amino acid carrier protein
E0Z08_RS05290	COG1752	Esterase of the alpha-beta hydrolase superfamily
E0Z08_RS05295	COG1607	acyl-coa hydrolase
E0Z08_RS05305	COG0523	cobalamin synthesis protein
E0Z08_RS05310	COG4681	YaeQ
E0Z08_RS05320	COG2199	diguanylate cyclase activity
E0Z08_RS05320	COG2203	Gaf domain
E0Z08_RS05325	COG0456	acetyltransferase
E0Z08_RS05365	COG0477	Major facilitator Superfamily
E0Z08_RS05370	COG0242	peptide deformylase activity
E0Z08_RS05375	COG2207	Transcriptional regulator
E0Z08_RS05380	COG2223	nitrite transmembrane transporter activity
E0Z08_RS05390	COG2852	Protein conserved in bacteria
E0Z08_RS05405	COG3293	Transposase
E0Z08_RS05415	COG0306	phosphate transporter
E0Z08_RS05435	COG4771	TonB-dependent receptor
E0Z08_RS05460	COG4181	ATPase activity
E0Z08_RS05465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E0Z08_RS05485	COG0583	DNA-binding transcription factor activity
E0Z08_RS05495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0Z08_RS05500	COG1773	rubredoxin
E0Z08_RS05505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E0Z08_RS05550	COG1695	Transcriptional regulator
E0Z08_RS05565	COG4221	oxidoreductase activity
E0Z08_RS05565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E0Z08_RS05565	COG0604	alcohol dehydrogenase
E0Z08_RS05565	COG3321	synthase
E0Z08_RS05590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E0Z08_RS05605	COG0477	Major facilitator Superfamily
E0Z08_RS05625	COG1597	lipid kinase activity
E0Z08_RS05745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E0Z08_RS05750	COG1335	isochorismatase
E0Z08_RS05780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E0Z08_RS05795	COG2323	membrane
E0Z08_RS05835	COG2223	nitrite transmembrane transporter activity
E0Z08_RS05840	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E0Z08_RS05845	COG1877	trehalose-phosphatase activity
E0Z08_RS05860	COG1570	exodeoxyribonuclease VII activity
E0Z08_RS05915	COG0582	viral genome integration into host DNA
E0Z08_RS05925	COG0641	radical SAM
E0Z08_RS05930	COG3119	arylsulfatase activity
E0Z08_RS05955	COG0742	ribosomal rna small subunit methyltransferase
E0Z08_RS05960	COG0768	penicillin binding
E0Z08_RS05985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E0Z08_RS05990	COG2878	Part of a membrane complex involved in electron transport
E0Z08_RS05995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E0Z08_RS06005	COG3384	dioxygenase
E0Z08_RS06015	COG2234	aminopeptidase activity
E0Z08_RS06030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E0Z08_RS06040	COG2217	Heavy metal translocating P-type atpase
E0Z08_RS06045	COG0583	DNA-binding transcription factor activity
E0Z08_RS06050	COG1914	H( )-stimulated, divalent metal cation uptake system
E0Z08_RS06070	COG4770	biotin carboxylase activity
E0Z08_RS06095	COG1785	Belongs to the alkaline phosphatase family
E0Z08_RS06100	COG1785	Belongs to the alkaline phosphatase family
E0Z08_RS06175	COG0006	proline dipeptidase activity
E0Z08_RS06190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0Z08_RS06195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0Z08_RS06215	COG2915	High frequency lysogenization protein hflD homolog
E0Z08_RS06235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E0Z08_RS06240	COG1686	Belongs to the peptidase S11 family
E0Z08_RS06270	COG0753	catalase activity
E0Z08_RS06350	COG2801	Transposase and inactivated derivatives
E0Z08_RS06355	COG2801	Transposase and inactivated derivatives
E0Z08_RS06360	COG2801	Transposase and inactivated derivatives
E0Z08_RS06390	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS06395	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS06400	COG2814	Major facilitator Superfamily
E0Z08_RS06405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E0Z08_RS06410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0Z08_RS06450	COG2814	Major facilitator Superfamily
E0Z08_RS06460	COG2814	Major facilitator Superfamily
E0Z08_RS06465	COG1024	Enoyl-CoA hydratase
E0Z08_RS06470	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0Z08_RS06475	COG0183	Belongs to the thiolase family
E0Z08_RS06485	COG0235	Class ii aldolase
E0Z08_RS06495	COG1024	Enoyl-CoA hydratase
E0Z08_RS06505	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS06525	COG0318	PFAM AMP-dependent synthetase and ligase
E0Z08_RS06530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0Z08_RS06535	COG2814	Major facilitator Superfamily
E0Z08_RS06540	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E0Z08_RS06540	COG0644	oxidoreductase
E0Z08_RS06545	COG3385	transposase activity
E0Z08_RS06550	COG2814	Major facilitator Superfamily
E0Z08_RS06555	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS06560	COG1024	Enoyl-CoA hydratase
E0Z08_RS06565	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0Z08_RS06570	COG0183	Belongs to the thiolase family
E0Z08_RS06575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0Z08_RS06590	COG0582	viral genome integration into host DNA
E0Z08_RS06600	COG1388	LysM domain
E0Z08_RS06600	COG4942	peptidase
E0Z08_RS06605	COG0583	DNA-binding transcription factor activity
E0Z08_RS06625	COG0657	acetylesterase activity
E0Z08_RS06630	COG2816	NAD+ diphosphatase activity
E0Z08_RS06640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0Z08_RS06645	COG0741	lytic transglycosylase activity
E0Z08_RS06645	COG1388	LysM domain
E0Z08_RS06650	COG4166	transmembrane transport
E0Z08_RS06655	COG4174	ABC transporter (Permease)
E0Z08_RS06660	COG4239	(ABC) transporter, permease
E0Z08_RS06665	COG4172	Belongs to the ABC transporter superfamily
E0Z08_RS06680	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E0Z08_RS06705	COG0833	amino acid
E0Z08_RS06715	COG0833	amino acid
E0Z08_RS06725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0Z08_RS06730	COG0418	dihydroorotase activity
E0Z08_RS06735	COG3706	GGDEF domain
E0Z08_RS06735	COG5001	Diguanylate cyclase
E0Z08_RS06735	COG4251	negative regulation of phosphorylation
E0Z08_RS06735	COG2203	Gaf domain
E0Z08_RS06750	COG2186	Transcriptional regulator
E0Z08_RS06760	COG0277	FAD linked oxidase domain protein
E0Z08_RS06765	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0Z08_RS06765	COG1902	pentaerythritol trinitrate reductase activity
E0Z08_RS06800	COG0280	phosphate acetyltransferase
E0Z08_RS06800	COG0281	malic enzyme
E0Z08_RS06805	COG5001	Diguanylate cyclase
E0Z08_RS06805	COG1716	ATPase activity
E0Z08_RS06810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E0Z08_RS06815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E0Z08_RS06820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E0Z08_RS06865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E0Z08_RS06870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0Z08_RS06880	COG1671	Belongs to the UPF0178 family
E0Z08_RS06895	COG4591	ABC-type transport system involved in lipoprotein release permease component
E0Z08_RS06900	COG1136	(ABC) transporter
E0Z08_RS06905	COG0658	competence protein
E0Z08_RS06905	COG2333	competence protein COMEC
E0Z08_RS06925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0Z08_RS06930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E0Z08_RS06935	COG0628	permease
E0Z08_RS06940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E0Z08_RS06975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0Z08_RS06995	COG0823	Involved in the tonB-independent uptake of proteins
E0Z08_RS07015	COG0824	Thioesterase
E0Z08_RS07030	COG2255	four-way junction helicase activity
E0Z08_RS07035	COG0632	four-way junction helicase activity
E0Z08_RS07045	COG3293	Transposase
E0Z08_RS07055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E0Z08_RS07055	COG0047	phosphoribosylformylglycinamidine synthase activity
E0Z08_RS07065	COG3323	Protein of unknown function (DUF1653)
E0Z08_RS07065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E0Z08_RS07070	COG0778	Nitroreductase
E0Z08_RS07075	COG1024	Enoyl-CoA hydratase
E0Z08_RS07080	COG1056	cytidyltransferase-related domain
E0Z08_RS07080	COG1051	belongs to the nudix hydrolase family
E0Z08_RS07085	COG2353	YceI-like domain
E0Z08_RS07090	COG0583	DNA-binding transcription factor activity
E0Z08_RS07100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0Z08_RS07115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E0Z08_RS07120	COG0602	queuosine metabolic process
E0Z08_RS07140	COG0583	DNA-binding transcription factor activity
E0Z08_RS07145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E0Z08_RS07150	COG4208	sulfate ABC transporter
E0Z08_RS07165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E0Z08_RS07175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E0Z08_RS07195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0Z08_RS07210	COG0681	Belongs to the peptidase S26 family
E0Z08_RS07225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E0Z08_RS07235	COG1381	Involved in DNA repair and RecF pathway recombination
E0Z08_RS07240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E0Z08_RS07275	COG0436	Aminotransferase
E0Z08_RS07280	COG3293	Transposase
E0Z08_RS07290	COG2199	diguanylate cyclase activity
E0Z08_RS07305	COG0556	nucleotide-excision repair
E0Z08_RS07335	COG0702	epimerase
E0Z08_RS07340	COG1733	regulation of RNA biosynthetic process
E0Z08_RS07350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E0Z08_RS07355	COG0671	phosphoesterase, PA-phosphatase related
E0Z08_RS07370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E0Z08_RS07375	COG0076	glutamate decarboxylase activity
E0Z08_RS07380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E0Z08_RS07385	COG0573	inorganic phosphate transmembrane transporter activity
E0Z08_RS07395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E0Z08_RS07400	COG0616	signal peptide processing
E0Z08_RS07405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0Z08_RS07410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E0Z08_RS07415	COG3385	transposase activity
E0Z08_RS07420	COG1067	ATP-dependent peptidase activity
E0Z08_RS07440	COG0254	rRNA binding
E0Z08_RS07455	COG1509	lysine 2,3-aminomutase activity
E0Z08_RS07460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E0Z08_RS07465	COG1966	Carbon starvation protein
E0Z08_RS07470	COG2879	small protein
E0Z08_RS07480	COG0714	Associated with various cellular activities
E0Z08_RS07615	COG2369	cell adhesion
E0Z08_RS07620	COG4383	Mu-like prophage protein gp29
E0Z08_RS07630	COG4373	Mu-like prophage FluMu protein gp28
E0Z08_RS07945	COG4695	Portal protein
E0Z08_RS07980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0Z08_RS07985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E0Z08_RS08005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E0Z08_RS08080	COG1131	(ABC) transporter
E0Z08_RS08085	COG0842	Transport permease protein
E0Z08_RS08090	COG0842	Transport permease protein
E0Z08_RS08115	COG1309	transcriptional regulator
E0Z08_RS08180	COG1733	regulation of RNA biosynthetic process
E0Z08_RS08185	COG0604	alcohol dehydrogenase
E0Z08_RS08195	COG1278	Cold shock
E0Z08_RS08215	COG3038	cytochrome b561
E0Z08_RS08225	COG2070	2-Nitropropane dioxygenase
E0Z08_RS08250	COG3634	alkyl hydroperoxide reductase activity
E0Z08_RS08270	COG0436	Aminotransferase
E0Z08_RS08275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0Z08_RS08280	COG0386	Belongs to the glutathione peroxidase family
E0Z08_RS08305	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E0Z08_RS08320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E0Z08_RS08345	COG0012	GTP binding
E0Z08_RS08350	COG2011	ABC-type metal ion transport system permease component
E0Z08_RS08355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E0Z08_RS08365	COG1464	Belongs to the NlpA lipoprotein family
E0Z08_RS08405	COG0204	Acyl-transferase
E0Z08_RS08560	COG1783	phage Terminase large subunit
E0Z08_RS08720	COG3772	lysozyme
E0Z08_RS08745	COG4372	Transposase
E0Z08_RS08760	COG1058	Belongs to the CinA family
E0Z08_RS08760	COG1546	Belongs to the CinA family
E0Z08_RS08780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0Z08_RS08785	COG0730	response to heat
E0Z08_RS08810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0Z08_RS08815	COG1944	ATP diphosphatase activity
E0Z08_RS08820	COG2207	Transcriptional regulator
E0Z08_RS08825	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0Z08_RS08830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E0Z08_RS08860	COG2223	nitrite transmembrane transporter activity
E0Z08_RS08875	COG1346	cytolysis
E0Z08_RS08880	COG1380	Effector of murein hydrolase LrgA
E0Z08_RS08885	COG0583	DNA-binding transcription factor activity
E0Z08_RS08890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0Z08_RS09060	COG5410	chromosome segregation
E0Z08_RS09070	COG2369	cell adhesion
E0Z08_RS09190	COG3772	lysozyme
E0Z08_RS09200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E0Z08_RS09270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0Z08_RS09275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E0Z08_RS09290	COG5001	Diguanylate cyclase
E0Z08_RS09290	COG3300	MHYT domain
E0Z08_RS09295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0Z08_RS09320	COG1132	(ABC) transporter
E0Z08_RS09330	COG0668	transmembrane transport
E0Z08_RS09335	COG3122	Protein conserved in bacteria
E0Z08_RS09355	COG0640	Transcriptional regulator
E0Z08_RS09360	COG0596	Alpha beta hydrolase
E0Z08_RS09365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0Z08_RS09370	COG1335	isochorismatase
E0Z08_RS09375	COG0251	oxidation-reduction process
E0Z08_RS09380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0Z08_RS09385	COG2233	PERMEase
E0Z08_RS09395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E0Z08_RS09405	COG0183	Belongs to the thiolase family
E0Z08_RS09410	COG0583	DNA-binding transcription factor activity
E0Z08_RS09425	COG0439	Biotin carboxylase
E0Z08_RS09440	COG0511	ligase activity, forming carbon-carbon bonds
E0Z08_RS09450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0Z08_RS09455	COG0183	Belongs to the thiolase family
E0Z08_RS09460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0Z08_RS09465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E0Z08_RS09470	COG3135	benzoate transporter
E0Z08_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS09480	COG0543	2 iron, 2 sulfur cluster binding
E0Z08_RS09480	COG0633	Ferredoxin
E0Z08_RS09485	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E0Z08_RS09490	COG4638	Rieske (2fe-2S)
E0Z08_RS09500	COG4829	muconolactone delta-isomerase
E0Z08_RS09505	COG4948	Mandelate Racemase Muconate Lactonizing
E0Z08_RS09510	COG0583	DNA-binding transcription factor activity
E0Z08_RS09515	COG2814	Major facilitator Superfamily
E0Z08_RS09600	COG0583	DNA-binding transcription factor activity
E0Z08_RS09610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z08_RS09615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0Z08_RS09625	COG5002	protein histidine kinase activity
E0Z08_RS09630	COG0745	RESPONSE REGULATOR receiver
E0Z08_RS09640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E0Z08_RS09645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E0Z08_RS09650	COG0022	dehydrogenase e1 component
E0Z08_RS09655	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0Z08_RS09660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0Z08_RS09670	COG1063	alcohol dehydrogenase
E0Z08_RS09680	COG0456	acetyltransferase
E0Z08_RS09730	COG1309	transcriptional regulator
E0Z08_RS09735	COG0604	alcohol dehydrogenase
E0Z08_RS09745	COG1253	flavin adenine dinucleotide binding
E0Z08_RS09785	COG2814	Major facilitator Superfamily
E0Z08_RS09855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0Z08_RS09860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E0Z08_RS10000	COG0596	Alpha beta hydrolase
E0Z08_RS10070	COG0864	Transcriptional regulator
E0Z08_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS10095	COG2814	Major facilitator Superfamily
E0Z08_RS10150	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS10155	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS10205	COG0552	protein localization to endoplasmic reticulum
E0Z08_RS10210	COG0612	Peptidase, M16
E0Z08_RS10240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E0Z08_RS10240	COG0517	IMP dehydrogenase activity
E0Z08_RS10245	COG0133	tryptophan synthase activity
E0Z08_RS10255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0Z08_RS10270	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E0Z08_RS10275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E0Z08_RS10310	COG0537	adenosine 5'-monophosphoramidase activity
E0Z08_RS10335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0Z08_RS10340	COG0776	regulation of translation
E0Z08_RS10355	COG1959	2 iron, 2 sulfur cluster binding
E0Z08_RS10365	COG0822	iron-sulfur transferase activity
E0Z08_RS10370	COG0316	Belongs to the HesB IscA family
E0Z08_RS10400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E0Z08_RS10410	COG1027	Aspartate ammonia-lyase
E0Z08_RS10420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0Z08_RS10430	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0Z08_RS10430	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0Z08_RS10430	COG0506	proline dehydrogenase activity
E0Z08_RS10465	COG3781	membrane
E0Z08_RS10470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0Z08_RS10480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0Z08_RS10505	COG0697	spore germination
E0Z08_RS10520	COG0126	phosphoglycerate kinase activity
E0Z08_RS10530	COG0424	maF-like protein
E0Z08_RS10540	COG2850	peptidyl-arginine hydroxylation
E0Z08_RS10545	COG4585	Histidine kinase
E0Z08_RS10560	COG0069	glutamate synthase activity
E0Z08_RS10580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E0Z08_RS10585	COG1454	alcohol dehydrogenase
E0Z08_RS10590	COG0824	Thioesterase
E0Z08_RS10595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E0Z08_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS10620	COG0183	Belongs to the thiolase family
E0Z08_RS10635	COG0583	DNA-binding transcription factor activity
E0Z08_RS10640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E0Z08_RS10650	COG3135	benzoate transporter
E0Z08_RS10660	COG1309	transcriptional regulator
E0Z08_RS10665	COG2076	Multidrug Resistance protein
E0Z08_RS10680	COG0589	response to stress
E0Z08_RS10690	COG0308	aminopeptidase N
E0Z08_RS10715	COG1253	flavin adenine dinucleotide binding
E0Z08_RS10735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E0Z08_RS10740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E0Z08_RS10755	COG2431	L-lysine efflux transmembrane transporter activity
E0Z08_RS10770	COG0776	regulation of translation
E0Z08_RS10790	COG0590	tRNA wobble adenosine to inosine editing
E0Z08_RS10800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E0Z08_RS10835	COG0084	hydrolase, TatD family'
E0Z08_RS10855	COG1663	tetraacyldisaccharide 4'-kinase activity
E0Z08_RS10860	COG1132	(ABC) transporter
E0Z08_RS10870	COG0811	peptide transport
E0Z08_RS10875	COG1475	DNA binding
E0Z08_RS10880	COG1192	Involved in chromosome partitioning
E0Z08_RS10890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E0Z08_RS10895	COG3178	'Phosphotransferase
E0Z08_RS10905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0Z08_RS10910	COG1923	regulation of RNA biosynthetic process
E0Z08_RS10920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E0Z08_RS10925	COG0802	atpase or kinase
E0Z08_RS10930	COG0564	pseudouridine synthase activity
E0Z08_RS10945	COG1187	pseudouridine synthase activity
E0Z08_RS10950	COG2707	UPF0756 membrane protein
E0Z08_RS10955	COG2814	Major facilitator Superfamily
E0Z08_RS10960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0Z08_RS10965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0Z08_RS10975	COG1454	alcohol dehydrogenase
E0Z08_RS10995	COG0531	amino acid
E0Z08_RS11000	COG4303	Ethanolamine ammonia lyase large subunit
E0Z08_RS11005	COG4302	ethanolamine ammonia-lyase activity
E0Z08_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS11025	COG0519	Catalyzes the synthesis of GMP from XMP
E0Z08_RS11025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E0Z08_RS11035	COG0456	acetyltransferase
E0Z08_RS11045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E0Z08_RS11050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E0Z08_RS11095	COG0352	thiamine-phosphate diphosphorylase activity
E0Z08_RS11130	COG0612	Peptidase, M16
E0Z08_RS11150	COG1823	symporter activity
E0Z08_RS11155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0Z08_RS11190	COG2351	hydroxyisourate hydrolase activity
E0Z08_RS11200	COG1686	Belongs to the peptidase S11 family
E0Z08_RS11205	COG1252	NADH dehydrogenase
E0Z08_RS11210	COG1047	Peptidyl-prolyl cis-trans
E0Z08_RS11215	COG1254	Belongs to the acylphosphatase family
E0Z08_RS11220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E0Z08_RS11220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E0Z08_RS11245	COG0318	PFAM AMP-dependent synthetase and ligase
E0Z08_RS11270	COG0372	Belongs to the citrate synthase family
E0Z08_RS11300	COG0542	response to heat
E0Z08_RS11305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E0Z08_RS11320	COG3706	GGDEF domain
E0Z08_RS11330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E0Z08_RS11335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0Z08_RS11345	COG0569	domain protein
E0Z08_RS11350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E0Z08_RS11370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0Z08_RS11380	COG1585	Membrane protein implicated in regulation of membrane protease activity
E0Z08_RS11395	COG1294	oxidase, subunit
E0Z08_RS11400	COG4890	Cyd operon protein YbgT
E0Z08_RS11415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E0Z08_RS11420	COG1309	transcriptional regulator
E0Z08_RS11425	COG1012	belongs to the aldehyde dehydrogenase family
E0Z08_RS11435	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS11440	COG0579	oxidoreductase
E0Z08_RS11455	COG0772	Belongs to the SEDS family
E0Z08_RS11470	COG0148	phosphopyruvate hydratase activity
E0Z08_RS11490	COG0583	DNA-binding transcription factor activity
E0Z08_RS11495	COG0656	L-ascorbic acid biosynthetic process
E0Z08_RS11500	COG2814	Major facilitator Superfamily
E0Z08_RS11515	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0Z08_RS11515	COG1902	pentaerythritol trinitrate reductase activity
E0Z08_RS11525	COG2267	carboxylic ester hydrolase activity
E0Z08_RS11535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E0Z08_RS11540	COG0702	epimerase
E0Z08_RS11600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E0Z08_RS11600	COG2755	lipolytic protein G-D-S-L family
E0Z08_RS11760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0Z08_RS11785	COG1011	Hydrolase
E0Z08_RS11790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E0Z08_RS11795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E0Z08_RS11800	COG2137	regulation of response to DNA damage stimulus
E0Z08_RS11810	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS11835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0Z08_RS11855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0Z08_RS11870	COG0575	Belongs to the CDS family
E0Z08_RS11875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E0Z08_RS11895	COG3852	Histidine kinase
E0Z08_RS11910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0Z08_RS11915	COG0583	DNA-binding transcription factor activity
E0Z08_RS11920	COG0024	Methionine aminopeptidase
E0Z08_RS11945	COG1113	amino acid transport
E0Z08_RS11955	COG0786	glutamate:sodium symporter activity
E0Z08_RS11960	COG4773	Receptor
E0Z08_RS12005	COG0729	surface antigen
E0Z08_RS12030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E0Z08_RS12045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0Z08_RS12050	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS12085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0Z08_RS12090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0Z08_RS12095	COG2890	protein-(glutamine-N5) methyltransferase activity
E0Z08_RS12100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E0Z08_RS12115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0Z08_RS12145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0Z08_RS12150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0Z08_RS12155	COG1845	cytochrome c oxidase, subunit III
E0Z08_RS12160	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E0Z08_RS12180	COG0360	Binds together with S18 to 16S ribosomal RNA
E0Z08_RS12195	COG0305	Participates in initiation and elongation during chromosome replication
E0Z08_RS12200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E0Z08_RS12215	COG1305	Transglutaminase-like
E0Z08_RS12225	COG2308	Evidence 4 Homologs of previously reported genes of
E0Z08_RS12245	COG0445	tRNA wobble uridine modification
E0Z08_RS12275	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E0Z08_RS12280	COG0138	bifunctional purine biosynthesis protein purh
E0Z08_RS12285	COG0151	Belongs to the GarS family
E0Z08_RS12295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E0Z08_RS12300	COG2011	ABC-type metal ion transport system permease component
E0Z08_RS12340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E0Z08_RS12350	COG4122	O-methyltransferase activity
E0Z08_RS12370	COG1137	ATPase activity
E0Z08_RS12375	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E0Z08_RS12385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E0Z08_RS12390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E0Z08_RS12390	COG0517	IMP dehydrogenase activity
E0Z08_RS12400	COG0406	alpha-ribazole phosphatase activity
E0Z08_RS12405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E0Z08_RS12440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E0Z08_RS12450	COG0243	molybdopterin cofactor binding
E0Z08_RS12455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0Z08_RS12460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0Z08_RS12465	COG2223	nitrite transmembrane transporter activity
E0Z08_RS12475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0Z08_RS12475	COG1116	anion transmembrane transporter activity
E0Z08_RS12495	COG1643	Atp-dependent helicase
E0Z08_RS12505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0Z08_RS12545	COG0515	serine threonine protein kinase
E0Z08_RS12545	COG2815	serine threonine protein kinase
E0Z08_RS12575	COG1610	YqeY-like protein
E0Z08_RS12580	COG4783	chaperone-mediated protein folding
E0Z08_RS12610	COG0167	dihydroorotate dehydrogenase activity
E0Z08_RS12635	COG0778	Nitroreductase
E0Z08_RS12645	COG0513	Belongs to the DEAD box helicase family
E0Z08_RS12650	COG1278	Cold shock
E0Z08_RS12665	COG2363	Small membrane protein
E0Z08_RS12690	COG2249	NAD(P)H dehydrogenase (quinone) activity
E0Z08_RS12695	COG0625	glutathione transferase activity
E0Z08_RS12700	COG0659	secondary active sulfate transmembrane transporter activity
E0Z08_RS12710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E0Z08_RS12740	COG0318	PFAM AMP-dependent synthetase and ligase
E0Z08_RS12745	COG1309	transcriptional regulator
E0Z08_RS12750	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS12755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E0Z08_RS12765	COG4770	biotin carboxylase activity
E0Z08_RS12780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0Z08_RS12785	COG2031	fatty acid transporter
E0Z08_RS12805	COG0540	Belongs to the ATCase OTCase family
E0Z08_RS12830	COG1765	OsmC-like protein
E0Z08_RS12840	COG0667	Aldo Keto reductase
E0Z08_RS12855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E0Z08_RS12870	COG1522	sequence-specific DNA binding
E0Z08_RS12875	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E0Z08_RS12890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0Z08_RS12900	COG0527	aspartate kinase activity
E0Z08_RS12910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E0Z08_RS12925	COG3038	cytochrome b561
E0Z08_RS12935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E0Z08_RS12940	COG2252	PERMEase
E0Z08_RS12950	COG0415	Belongs to the DNA photolyase family
E0Z08_RS12980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E0Z08_RS12985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E0Z08_RS12995	COG0693	protein deglycase activity
E0Z08_RS13000	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS13010	COG1301	dicarboxylic acid transport
E0Z08_RS13025	COG3139	Protein of unknown function (DUF1315)
E0Z08_RS13030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E0Z08_RS13035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E0Z08_RS13045	COG0494	nUDIX hydrolase
E0Z08_RS13055	COG0642	Histidine kinase
E0Z08_RS13070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E0Z08_RS13080	COG1720	tRNA m6t6A37 methyltransferase activity
E0Z08_RS13135	COG0826	peptidase U32
E0Z08_RS13140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0Z08_RS13145	COG3634	alkyl hydroperoxide reductase activity
E0Z08_RS13165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0Z08_RS13215	COG3706	GGDEF domain
E0Z08_RS13220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0Z08_RS13220	COG0475	glutathione-regulated potassium exporter activity
E0Z08_RS13225	COG0697	spore germination
E0Z08_RS13230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0Z08_RS13235	COG0235	Class ii aldolase
E0Z08_RS13240	COG2169	Transcriptional regulator
E0Z08_RS13260	COG4149	molybdate abc transporter
E0Z08_RS13265	COG0725	ABC transporter, periplasmic molybdate-binding protein
E0Z08_RS13275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E0Z08_RS13280	COG0243	molybdopterin cofactor binding
E0Z08_RS13285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E0Z08_RS13290	COG0315	cyclic pyranopterin monophosphate synthase activity
E0Z08_RS13290	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0Z08_RS13295	COG0303	'Molybdopterin
E0Z08_RS13305	COG1131	(ABC) transporter
E0Z08_RS13310	COG0842	Transport permease protein
E0Z08_RS13325	COG2951	lytic endotransglycosylase activity
E0Z08_RS13360	COG0052	Belongs to the universal ribosomal protein uS2 family
E0Z08_RS13380	COG2175	clavaminate synthase activity
E0Z08_RS13395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z08_RS13400	COG0842	Transport permease protein
E0Z08_RS13435	COG1280	lysine exporter protein (LysE YggA)
E0Z08_RS13440	COG1522	sequence-specific DNA binding
E0Z08_RS13445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E0Z08_RS13455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E0Z08_RS13465	COG0019	diaminopimelate decarboxylase activity
E0Z08_RS13475	COG1113	amino acid transport
E0Z08_RS13480	COG1115	amino acid carrier protein
E0Z08_RS13495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0Z08_RS13500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E0Z08_RS13505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0Z08_RS13510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0Z08_RS13550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E0Z08_RS13555	COG3161	chorismate lyase activity
E0Z08_RS13565	COG0174	glutamine synthetase
E0Z08_RS13570	COG0512	Glutamine amidotransferase of anthranilate synthase
E0Z08_RS13575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E0Z08_RS13580	COG0134	indole-3-glycerol-phosphate synthase activity
E0Z08_RS13595	COG0302	gtp cyclohydrolase
E0Z08_RS13605	COG3706	GGDEF domain
E0Z08_RS13620	COG3739	integral membrane protein
E0Z08_RS13640	COG1741	Belongs to the pirin family
E0Z08_RS13655	COG1309	transcriptional regulator
E0Z08_RS13665	COG0697	spore germination
E0Z08_RS13685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0Z08_RS13690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E0Z08_RS13700	COG0037	tRNA processing
E0Z08_RS13705	COG0741	lytic transglycosylase activity
E0Z08_RS13710	COG0501	Belongs to the peptidase M48B family
E0Z08_RS13725	COG2239	Acts as a magnesium transporter
E0Z08_RS13755	COG1253	flavin adenine dinucleotide binding
E0Z08_RS13760	COG2851	Citrate transporter
E0Z08_RS13800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E0Z08_RS13805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0Z08_RS13830	COG0505	Belongs to the CarA family
E0Z08_RS13835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0Z08_RS13860	COG3695	enzyme binding
E0Z08_RS13875	COG2321	neutral zinc metallopeptidase
E0Z08_RS13880	COG2354	Protein conserved in bacteria
E0Z08_RS13890	COG1585	Membrane protein implicated in regulation of membrane protease activity
E0Z08_RS13895	COG2268	Band 7 protein
E0Z08_RS13905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0Z08_RS13915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0Z08_RS13930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E0Z08_RS13935	COG1053	succinate dehydrogenase
E0Z08_RS13940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E0Z08_RS13945	COG2009	succinate dehydrogenase
E0Z08_RS13955	COG2072	flavoprotein involved in K transport
E0Z08_RS13975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E0Z08_RS13975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0Z08_RS14000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0Z08_RS14025	COG0564	pseudouridine synthase activity
E0Z08_RS14035	COG0358	DNA primase activity
E0Z08_RS14050	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E0Z08_RS14080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E0Z08_RS14085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E0Z08_RS14110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E0Z08_RS14135	COG0586	Pfam SNARE associated Golgi protein
E0Z08_RS14150	COG1280	lysine exporter protein (LysE YggA)
E0Z08_RS14170	COG2921	Belongs to the UPF0250 family
E0Z08_RS14175	COG0321	lipoyl(octanoyl) transferase activity
E0Z08_RS14190	COG0531	amino acid
E0Z08_RS14210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E0Z08_RS14215	COG1648	precorrin-2 dehydrogenase activity
E0Z08_RS14215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E0Z08_RS14220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E0Z08_RS14230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E0Z08_RS14240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E0Z08_RS14260	COG0671	phosphoesterase, PA-phosphatase related
E0Z08_RS14265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z08_RS14275	COG1538	Outer membrane efflux protein
E0Z08_RS14280	COG0393	Putative heavy-metal-binding
E0Z08_RS14295	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS14305	COG0525	valine-tRNA ligase activity
E0Z08_RS14315	COG0525	valine-tRNA ligase activity
E0Z08_RS14325	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS14330	COG2852	Protein conserved in bacteria
E0Z08_RS14350	COG0583	DNA-binding transcription factor activity
E0Z08_RS14355	COG1278	Cold shock
E0Z08_RS14360	COG1278	Cold shock
E0Z08_RS14380	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0Z08_RS14385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0Z08_RS14390	COG0713	ATP synthesis coupled electron transport
E0Z08_RS14400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0Z08_RS14415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E0Z08_RS14435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0Z08_RS14445	COG2205	protein histidine kinase activity
E0Z08_RS14450	COG0745	RESPONSE REGULATOR receiver
E0Z08_RS14460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0Z08_RS14495	COG0439	Biotin carboxylase
E0Z08_RS14500	COG1802	Transcriptional regulator
E0Z08_RS14505	COG1652	LysM domain
E0Z08_RS14515	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z08_RS14530	COG1399	metal-binding, possibly nucleic acid-binding protein
E0Z08_RS14535	COG3101	peptidyl-lysine hydroxylation
E0Z08_RS14540	COG0009	L-threonylcarbamoyladenylate synthase
E0Z08_RS14550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E0Z08_RS14555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E0Z08_RS14645	COG4397	Mu-like prophage major head subunit gpT
E0Z08_RS14665	COG2369	cell adhesion
E0Z08_RS14670	COG4383	Mu-like prophage protein gp29
E0Z08_RS14690	COG4373	Mu-like prophage FluMu protein gp28
E0Z08_RS14730	COG2932	Transcriptional regulator
E0Z08_RS14810	COG4382	Mu-like prophage protein Gp16
E0Z08_RS14850	COG4206	TonB-dependent receptor
E0Z08_RS14880	COG4106	trans-aconitate 2-methyltransferase activity
E0Z08_RS14895	COG2267	carboxylic ester hydrolase activity
E0Z08_RS14900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0Z08_RS14905	COG2193	ferroxidase activity
E0Z08_RS14925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0Z08_RS14930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E0Z08_RS14935	COG3115	cell septum assembly
E0Z08_RS14940	COG1196	nuclear chromosome segregation
E0Z08_RS14950	COG0730	response to heat
E0Z08_RS14970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E0Z08_RS14985	COG0488	(ABC) transporter
E0Z08_RS15010	COG3422	double-strand break repair
E0Z08_RS15020	COG2824	Alkylphosphonate utilization operon protein PhnA
E0Z08_RS15025	COG3189	MarR family transcriptional regulator
E0Z08_RS15045	COG0564	pseudouridine synthase activity
E0Z08_RS15050	COG0346	lactoylglutathione lyase activity
E0Z08_RS15085	COG1487	ribonuclease activity
E0Z08_RS15090	COG4456	Virulence-associated protein
E0Z08_RS15105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0Z08_RS15135	COG1902	pentaerythritol trinitrate reductase activity
E0Z08_RS15140	COG3659	wide pore channel activity
E0Z08_RS15150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0Z08_RS15160	COG1970	mechanosensitive ion channel activity
E0Z08_RS15165	COG1217	gtp-binding protein TYPA
E0Z08_RS15170	COG2233	PERMEase
E0Z08_RS15175	COG2813	Specifically methylates the guanine in position
E0Z08_RS15180	COG0833	amino acid
E0Z08_RS15195	COG0183	Belongs to the thiolase family
E0Z08_RS15215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0Z08_RS15230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0Z08_RS15235	COG2207	Transcriptional regulator
E0Z08_RS15240	COG0183	Belongs to the thiolase family
E0Z08_RS15245	COG1024	Enoyl-CoA hydratase
E0Z08_RS15245	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0Z08_RS15265	COG1272	protein, Hemolysin III
E0Z08_RS15270	COG0477	Major facilitator Superfamily
E0Z08_RS15280	COG1408	metallophosphoesterase
E0Z08_RS15285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0Z08_RS15295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E0Z08_RS15320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E0Z08_RS15325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E0Z08_RS15330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E0Z08_RS15335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E0Z08_RS15340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E0Z08_RS15350	COG0625	glutathione transferase activity
E0Z08_RS15355	COG2969	positive regulation of protein catabolic process
E0Z08_RS15455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E0Z08_RS15460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E0Z08_RS15480	COG0450	alkyl hydroperoxide reductase
E0Z08_RS15500	COG0285	dihydrofolate synthase activity
E0Z08_RS15530	COG3083	sulfuric ester hydrolase activity
E0Z08_RS15555	COG4206	TonB-dependent receptor
E0Z08_RS15560	COG2096	Adenosyltransferase
E0Z08_RS15580	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E0Z08_RS15585	COG2315	Protein conserved in bacteria
E0Z08_RS15590	COG1113	amino acid transport
E0Z08_RS15595	COG0745	RESPONSE REGULATOR receiver
E0Z08_RS15600	COG2205	protein histidine kinase activity
E0Z08_RS15610	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS15615	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS15620	COG3223	Belongs to the PsiE family
E0Z08_RS15650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E0Z08_RS15700	COG0438	transferase activity, transferring glycosyl groups
E0Z08_RS15720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E0Z08_RS15725	COG5002	protein histidine kinase activity
E0Z08_RS15735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E0Z08_RS15745	COG1704	LemA family
E0Z08_RS15755	COG1862	Preprotein translocase
E0Z08_RS15795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0Z08_RS15815	COG1426	Protein conserved in bacteria
E0Z08_RS15880	COG0440	acetolactate synthase activity
E0Z08_RS15885	COG0028	Belongs to the TPP enzyme family
E0Z08_RS15910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z08_RS15915	COG1136	(ABC) transporter
E0Z08_RS15915	COG0577	efflux transmembrane transporter activity
E0Z08_RS15920	COG1538	Outer membrane efflux protein
E0Z08_RS15945	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E0Z08_RS15950	COG1162	GTPase activity
E0Z08_RS15975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E0Z08_RS15985	COG3781	membrane
E0Z08_RS15990	COG0613	PHP domain protein
E0Z08_RS16000	COG2350	Protein conserved in bacteria
E0Z08_RS16020	COG1666	GTP binding
E0Z08_RS16035	COG1607	acyl-coa hydrolase
E0Z08_RS16060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0Z08_RS16095	COG1183	phosphatidylcholine synthase activity
E0Z08_RS16100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E0Z08_RS16125	COG0039	L-malate dehydrogenase activity
E0Z08_RS16135	COG1196	nuclear chromosome segregation
E0Z08_RS16135	COG0739	heme binding
E0Z08_RS16135	COG0741	lytic transglycosylase activity
E0Z08_RS16140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0Z08_RS16145	COG1702	phosphate starvation-inducible protein PhoH
E0Z08_RS16150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E0Z08_RS16195	COG1295	ribonuclease BN
E0Z08_RS16210	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0Z08_RS16245	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS16260	COG0339	signal peptide processing
E0Z08_RS16265	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E0Z08_RS16295	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E0Z08_RS16300	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS16310	COG2072	flavoprotein involved in K transport
E0Z08_RS16315	COG0203	ribosomal protein L17
E0Z08_RS16320	COG0202	RNA polymerase activity
E0Z08_RS16335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E0Z08_RS16360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E0Z08_RS16370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E0Z08_RS16375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E0Z08_RS16425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E0Z08_RS16440	COG0088	Forms part of the polypeptide exit tunnel
E0Z08_RS16445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E0Z08_RS16465	COG0433	COG0433 Predicted ATPase
E0Z08_RS16475	COG1959	2 iron, 2 sulfur cluster binding
E0Z08_RS16490	COG1301	dicarboxylic acid transport
E0Z08_RS16495	COG1946	Acyl-CoA thioesterase
E0Z08_RS16500	COG2937	Belongs to the GPAT DAPAT family
E0Z08_RS16520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E0Z08_RS16525	COG1040	competence protein
E0Z08_RS16540	COG0598	Magnesium transport protein CorA
E0Z08_RS16550	COG2854	intermembrane phospholipid transfer
E0Z08_RS16555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0Z08_RS16560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E0Z08_RS16565	COG1127	ABC transporter
E0Z08_RS16570	COG0513	Belongs to the DEAD box helicase family
E0Z08_RS16590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0Z08_RS16595	COG0408	coproporphyrinogen oxidase activity
E0Z08_RS16615	COG1960	acyl-CoA dehydrogenase activity
E0Z08_RS16635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0Z08_RS16645	COG0534	Mate efflux family protein
E0Z08_RS16655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E0Z08_RS16660	COG0254	rRNA binding
E0Z08_RS16665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E0Z08_RS16680	COG2226	methyltransferase
E0Z08_RS16690	COG1192	Involved in chromosome partitioning
E0Z08_RS16695	COG0628	permease
E0Z08_RS16700	COG2032	superoxide dismutase activity
E0Z08_RS16705	COG1289	transmembrane transporter activity
E0Z08_RS16710	COG2814	Major facilitator Superfamily
E0Z08_RS16735	COG0277	FAD linked oxidase domain protein
E0Z08_RS16740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0Z08_RS16745	COG5006	permease, DMT superfamily
E0Z08_RS16765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E0Z08_RS16770	COG5380	lipid catabolic process
E0Z08_RS16785	COG0335	large ribosomal subunit rRNA binding
E0Z08_RS16795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E0Z08_RS16800	COG0228	four-way junction DNA binding
E0Z08_RS16850	COG0194	GDP metabolic process
E0Z08_RS16855	COG1758	RNA polymerase activity
E0Z08_RS16860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0Z08_RS16910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E0Z08_RS16915	COG1704	LemA family
E0Z08_RS16930	COG0493	'glutamate synthase
E0Z08_RS16935	COG0070	glutamate synthase
E0Z08_RS16935	COG0069	glutamate synthase activity
E0Z08_RS16935	COG0067	glutamate synthase
E0Z08_RS16995	COG3385	transposase activity
E0Z08_RS17000	COG2226	methyltransferase
E0Z08_RS17010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E0Z08_RS17015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0Z08_RS17035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E0Z08_RS17100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0Z08_RS17120	COG0488	(ABC) transporter
E0Z08_RS17125	COG2873	o-acetylhomoserine
E0Z08_RS17130	COG4221	oxidoreductase activity
E0Z08_RS17160	COG0427	acetyl-CoA hydrolase
E0Z08_RS17195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E0Z08_RS17225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0Z08_RS17230	COG0531	amino acid
E0Z08_RS17245	COG1278	Cold shock
E0Z08_RS17250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E0Z08_RS17280	COG0675	Transposase, IS605 OrfB family
E0Z08_RS17320	COG0582	viral genome integration into host DNA
E0Z08_RS17385	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E0Z08_RS17410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0Z08_RS17430	COG1301	dicarboxylic acid transport
E0Z08_RS17435	COG0583	DNA-binding transcription factor activity
E0Z08_RS17455	COG0732	type I restriction modification DNA specificity domain
E0Z08_RS17525	COG2217	Heavy metal translocating P-type atpase
E0Z08_RS17530	COG3174	membrane
E0Z08_RS17535	COG2205	protein histidine kinase activity
E0Z08_RS17550	COG2132	Multicopper oxidase
E0Z08_RS17585	COG2826	transposase and inactivated derivatives, IS30 family
E0Z08_RS17605	COG0629	single-stranded DNA binding
E0Z08_RS17610	COG2814	Major facilitator Superfamily
E0Z08_RS17620	COG0352	thiamine-phosphate diphosphorylase activity
E0Z08_RS17620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E0Z08_RS17620	COG0351	phosphomethylpyrimidine kinase
E0Z08_RS17640	COG3706	GGDEF domain
E0Z08_RS17650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E0Z08_RS17660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0Z08_RS17665	COG3162	membrane
E0Z08_RS17670	COG2205	protein histidine kinase activity
E0Z08_RS17670	COG0784	Response regulator, receiver
E0Z08_RS17685	COG0431	NADPH-dependent FMN reductase
E0Z08_RS17705	COG0307	riboflavin synthase, alpha
E0Z08_RS17710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0Z08_RS17715	COG0668	transmembrane transport
E0Z08_RS17720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E0Z08_RS17725	COG1519	Transferase
E0Z08_RS17730	COG1902	pentaerythritol trinitrate reductase activity
E0Z08_RS17760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E0Z08_RS17785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0Z08_RS17785	COG0426	domain, Protein
E0Z08_RS17790	COG2119	membrane
E0Z08_RS17820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E0Z08_RS17830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E0Z08_RS17840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0Z08_RS17850	COG0189	ligase activity
E0Z08_RS17855	COG0386	Belongs to the glutathione peroxidase family
E0Z08_RS17860	COG1846	Transcriptional regulator
E0Z08_RS17885	COG0708	Exodeoxyribonuclease III
E0Z08_RS17890	COG1393	Belongs to the ArsC family
E0Z08_RS17905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E0Z08_RS17990	COG3150	esterase
E0Z08_RS18000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E0Z08_RS18005	COG2918	glutathione biosynthetic process
E0Z08_RS18020	COG2733	membrane
E0Z08_RS18025	COG0436	Aminotransferase
E0Z08_RS18030	COG0534	Mate efflux family protein
E0Z08_RS18100	COG0385	Bile acid
E0Z08_RS18105	COG1335	isochorismatase
E0Z08_RS18115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0Z08_RS18140	COG4215	(ABC) transporter
E0Z08_RS18145	COG4160	amino acid transport
E0Z08_RS18155	COG1522	sequence-specific DNA binding
E0Z08_RS18165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E0Z08_RS18170	COG2983	Belongs to the UPF0260 family
E0Z08_RS18175	COG5487	UPF0391 membrane protein
E0Z08_RS18205	COG2818	Glycosylase
E0Z08_RS18210	COG1064	alcohol dehydrogenase
E0Z08_RS18215	COG0436	Aminotransferase
E0Z08_RS18230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E0Z08_RS18260	COG1309	transcriptional regulator
E0Z08_RS18270	COG2233	PERMEase
E0Z08_RS18275	COG0583	DNA-binding transcription factor activity
E0Z08_RS18285	COG4774	siderophore transport
E0Z08_RS18295	COG0129	dihydroxy-acid dehydratase activity
E0Z08_RS18305	COG3293	Transposase
E0Z08_RS18315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E0Z08_RS18315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0Z08_RS18340	COG0733	neurotransmitter:sodium symporter activity
E0Z08_RS18350	COG2814	Major facilitator Superfamily
E0Z08_RS18380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E0Z08_RS18390	COG0657	acetylesterase activity
E0Z08_RS18405	COG3293	Transposase
E0Z08_RS18460	COG0488	(ABC) transporter
E0Z08_RS18470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E0Z08_RS18485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0Z08_RS18515	COG0861	Integral membrane protein TerC family
E0Z08_RS18525	COG0754	glutathionylspermidine amidase activity
E0Z08_RS18535	COG0402	S-adenosylhomocysteine deaminase activity
E0Z08_RS18555	COG1230	cation diffusion facilitator family transporter
E0Z08_RS18570	COG0583	DNA-binding transcription factor activity
E0Z08_RS18585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E0Z08_RS18590	COG0281	malic enzyme
E0Z08_RS18600	COG0706	membrane insertase activity
E0Z08_RS18605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E0Z08_RS18640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E0Z08_RS18645	COG2948	multi-organism process
E0Z08_RS18655	COG3504	Conjugal transfer protein
E0Z08_RS18660	COG3701	Conjugal transfer protein
E0Z08_RS18665	COG3846	protein secretion by the type IV secretion system
E0Z08_RS18680	COG3451	type IV secretory pathway VirB4
E0Z08_RS18695	COG4962	Type ii secretion system protein e
E0Z08_RS18800	COG0739	heme binding
E0Z08_RS18800	COG1196	nuclear chromosome segregation
E0Z08_RS18800	COG0741	lytic transglycosylase activity