locus-tag	class	description
JW980_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JW980_RS00010	COG0592	DNA-directed DNA polymerase activity
JW980_RS00020	COG0187	DNA topoisomerase II activity
JW980_RS00030	COG4372	Transposase
JW980_RS00045	COG0488	(ABC) transporter
JW980_RS00105	COG0657	acetylesterase activity
JW980_RS00115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JW980_RS00145	COG2814	Major facilitator Superfamily
JW980_RS00155	COG0733	neurotransmitter:sodium symporter activity
JW980_RS00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JW980_RS00180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JW980_RS00195	COG0129	dihydroxy-acid dehydratase activity
JW980_RS00220	COG4372	Transposase
JW980_RS00235	COG0583	DNA-binding transcription factor activity
JW980_RS00240	COG2233	PERMEase
JW980_RS00250	COG1309	transcriptional regulator
JW980_RS00270	COG0484	heat shock protein binding
JW980_RS00295	COG0675	Transposase, IS605 OrfB family
JW980_RS00310	COG0436	Aminotransferase
JW980_RS00315	COG1064	alcohol dehydrogenase
JW980_RS00320	COG2818	Glycosylase
JW980_RS00350	COG3293	Transposase
JW980_RS00355	COG5487	UPF0391 membrane protein
JW980_RS00360	COG2983	Belongs to the UPF0260 family
JW980_RS00365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JW980_RS00385	COG4160	amino acid transport
JW980_RS00390	COG4215	(ABC) transporter
JW980_RS00410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JW980_RS00415	COG1335	isochorismatase
JW980_RS00420	COG0385	Bile acid
JW980_RS00440	COG4372	Transposase
JW980_RS00465	COG3385	transposase activity
JW980_RS00510	COG0534	Mate efflux family protein
JW980_RS00515	COG0436	Aminotransferase
JW980_RS00520	COG2733	membrane
JW980_RS00535	COG2918	glutathione biosynthetic process
JW980_RS00540	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JW980_RS00550	COG3150	esterase
JW980_RS00640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JW980_RS00655	COG1393	Belongs to the ArsC family
JW980_RS00660	COG0708	Exodeoxyribonuclease III
JW980_RS00670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JW980_RS00685	COG1846	Transcriptional regulator
JW980_RS00690	COG0386	Belongs to the glutathione peroxidase family
JW980_RS00695	COG0189	ligase activity
JW980_RS00705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JW980_RS00715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JW980_RS00725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JW980_RS00755	COG2119	membrane
JW980_RS00785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JW980_RS00810	COG1902	pentaerythritol trinitrate reductase activity
JW980_RS00815	COG1519	Transferase
JW980_RS00820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JW980_RS00825	COG0668	transmembrane transport
JW980_RS00830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JW980_RS00835	COG0307	riboflavin synthase, alpha
JW980_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS00855	COG0431	NADPH-dependent FMN reductase
JW980_RS00870	COG0784	Response regulator, receiver
JW980_RS00870	COG2205	protein histidine kinase activity
JW980_RS00875	COG3162	membrane
JW980_RS00880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JW980_RS00890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JW980_RS00900	COG3706	GGDEF domain
JW980_RS00925	COG0352	thiamine-phosphate diphosphorylase activity
JW980_RS00925	COG0351	phosphomethylpyrimidine kinase
JW980_RS00925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JW980_RS00935	COG2814	Major facilitator Superfamily
JW980_RS00940	COG0629	single-stranded DNA binding
JW980_RS00945	COG0629	single-stranded DNA binding
JW980_RS00955	COG0583	DNA-binding transcription factor activity
JW980_RS00975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JW980_RS00985	COG0583	DNA-binding transcription factor activity
JW980_RS00990	COG1335	isochorismatase
JW980_RS01000	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
JW980_RS01095	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
JW980_RS01105	COG0732	type I restriction modification DNA specificity domain
JW980_RS01145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JW980_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS01155	COG3118	belongs to the thioredoxin family
JW980_RS01160	COG1902	pentaerythritol trinitrate reductase activity
JW980_RS01215	COG2826	transposase and inactivated derivatives, IS30 family
JW980_RS01260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JW980_RS01265	COG1278	Cold shock
JW980_RS01280	COG0531	amino acid
JW980_RS01285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JW980_RS01315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JW980_RS01350	COG0427	acetyl-CoA hydrolase
JW980_RS01395	COG4221	oxidoreductase activity
JW980_RS01400	COG2873	o-acetylhomoserine
JW980_RS01405	COG0488	(ABC) transporter
JW980_RS01425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JW980_RS01450	COG2433	Pfam Transposase IS66
JW980_RS01480	COG4372	Transposase
JW980_RS01500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JW980_RS01520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JW980_RS01525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JW980_RS01535	COG2226	methyltransferase
JW980_RS01585	COG0070	glutamate synthase
JW980_RS01585	COG0067	glutamate synthase
JW980_RS01585	COG0069	glutamate synthase activity
JW980_RS01590	COG0493	'glutamate synthase
JW980_RS01600	COG1704	LemA family
JW980_RS01605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JW980_RS01670	COG4969	Belongs to the N-Me-Phe pilin family
JW980_RS01680	COG4969	Belongs to the N-Me-Phe pilin family
JW980_RS01700	COG2906	2 iron, 2 sulfur cluster binding
JW980_RS01710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JW980_RS01715	COG1758	RNA polymerase activity
JW980_RS01720	COG0194	GDP metabolic process
JW980_RS01770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JW980_RS01780	COG0335	large ribosomal subunit rRNA binding
JW980_RS01795	COG5380	lipid catabolic process
JW980_RS01800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JW980_RS01820	COG5006	permease, DMT superfamily
JW980_RS01825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JW980_RS01830	COG0277	FAD linked oxidase domain protein
JW980_RS01875	COG2814	Major facilitator Superfamily
JW980_RS01880	COG1289	transmembrane transporter activity
JW980_RS01885	COG2032	superoxide dismutase activity
JW980_RS01890	COG0628	permease
JW980_RS01895	COG1192	Involved in chromosome partitioning
JW980_RS01905	COG2226	methyltransferase
JW980_RS01920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JW980_RS01925	COG0254	rRNA binding
JW980_RS01930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JW980_RS01940	COG0534	Mate efflux family protein
JW980_RS01950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JW980_RS01970	COG1960	acyl-CoA dehydrogenase activity
JW980_RS01990	COG0408	coproporphyrinogen oxidase activity
JW980_RS01995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JW980_RS02005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JW980_RS02015	COG0513	Belongs to the DEAD box helicase family
JW980_RS02020	COG1127	ABC transporter
JW980_RS02025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JW980_RS02030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JW980_RS02035	COG2854	intermembrane phospholipid transfer
JW980_RS02045	COG0598	Magnesium transport protein CorA
JW980_RS02055	COG0494	nUDIX hydrolase
JW980_RS02060	COG1040	competence protein
JW980_RS02065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JW980_RS02085	COG2937	Belongs to the GPAT DAPAT family
JW980_RS02090	COG1946	Acyl-CoA thioesterase
JW980_RS02095	COG1301	dicarboxylic acid transport
JW980_RS02110	COG1959	2 iron, 2 sulfur cluster binding
JW980_RS02120	COG0433	COG0433 Predicted ATPase
JW980_RS02140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JW980_RS02145	COG0088	Forms part of the polypeptide exit tunnel
JW980_RS02160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JW980_RS02210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JW980_RS02215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JW980_RS02225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JW980_RS02250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JW980_RS02265	COG0202	RNA polymerase activity
JW980_RS02270	COG0203	ribosomal protein L17
JW980_RS02275	COG2072	flavoprotein involved in K transport
JW980_RS02285	COG1960	acyl-CoA dehydrogenase activity
JW980_RS02290	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JW980_RS02320	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JW980_RS02325	COG0339	signal peptide processing
JW980_RS02330	COG2720	vancomycin resistance protein
JW980_RS02335	COG0557	exoribonuclease II activity
JW980_RS02365	COG0179	Fumarylacetoacetate (FAA) hydrolase
JW980_RS02380	COG1295	ribonuclease BN
JW980_RS02425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JW980_RS02430	COG1702	phosphate starvation-inducible protein PhoH
JW980_RS02435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JW980_RS02440	COG0739	heme binding
JW980_RS02440	COG0741	lytic transglycosylase activity
JW980_RS02440	COG1196	nuclear chromosome segregation
JW980_RS02450	COG0039	L-malate dehydrogenase activity
JW980_RS02475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JW980_RS02480	COG1183	phosphatidylcholine synthase activity
JW980_RS02515	COG4372	Transposase
JW980_RS02530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW980_RS02555	COG1607	acyl-coa hydrolase
JW980_RS02570	COG1666	GTP binding
JW980_RS02590	COG2350	Protein conserved in bacteria
JW980_RS02600	COG0613	PHP domain protein
JW980_RS02605	COG3781	membrane
JW980_RS02615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JW980_RS02640	COG1162	GTPase activity
JW980_RS02645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JW980_RS02670	COG1538	Outer membrane efflux protein
JW980_RS02675	COG1136	(ABC) transporter
JW980_RS02675	COG0577	efflux transmembrane transporter activity
JW980_RS02680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW980_RS02705	COG0028	Belongs to the TPP enzyme family
JW980_RS02710	COG0440	acetolactate synthase activity
JW980_RS02740	COG0438	transferase activity, transferring glycosyl groups
JW980_RS02770	COG1426	Protein conserved in bacteria
JW980_RS02790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JW980_RS02815	COG1862	Preprotein translocase
JW980_RS02830	COG0675	Transposase, IS605 OrfB family
JW980_RS02845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JW980_RS02855	COG5002	protein histidine kinase activity
JW980_RS02860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JW980_RS02880	COG0463	Glycosyl transferase, family 2
JW980_RS02890	COG0438	transferase activity, transferring glycosyl groups
JW980_RS02930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JW980_RS02960	COG3223	Belongs to the PsiE family
JW980_RS02965	COG4372	Transposase
JW980_RS02980	COG1960	acyl-CoA dehydrogenase activity
JW980_RS02985	COG1960	acyl-CoA dehydrogenase activity
JW980_RS02995	COG2205	protein histidine kinase activity
JW980_RS03000	COG0745	RESPONSE REGULATOR receiver
JW980_RS03005	COG1113	amino acid transport
JW980_RS03015	COG2315	Protein conserved in bacteria
JW980_RS03020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JW980_RS03040	COG2096	Adenosyltransferase
JW980_RS03045	COG4206	TonB-dependent receptor
JW980_RS03105	COG0285	dihydrofolate synthase activity
JW980_RS03125	COG0450	alkyl hydroperoxide reductase
JW980_RS03150	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JW980_RS03155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JW980_RS03185	COG2199	diguanylate cyclase activity
JW980_RS03245	COG2969	positive regulation of protein catabolic process
JW980_RS03250	COG0625	glutathione transferase activity
JW980_RS03260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JW980_RS03265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JW980_RS03270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JW980_RS03275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JW980_RS03280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JW980_RS03305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JW980_RS03315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JW980_RS03320	COG1408	metallophosphoesterase
JW980_RS03330	COG0477	Major facilitator Superfamily
JW980_RS03335	COG1272	protein, Hemolysin III
JW980_RS03355	COG1250	3-hydroxyacyl-CoA dehydrogenase
JW980_RS03355	COG1024	Enoyl-CoA hydratase
JW980_RS03360	COG0183	Belongs to the thiolase family
JW980_RS03365	COG2207	Transcriptional regulator
JW980_RS03370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JW980_RS03385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW980_RS03410	COG0183	Belongs to the thiolase family
JW980_RS03425	COG0833	amino acid
JW980_RS03430	COG2813	Specifically methylates the guanine in position
JW980_RS03435	COG2233	PERMEase
JW980_RS03440	COG1217	gtp-binding protein TYPA
JW980_RS03445	COG1970	mechanosensitive ion channel activity
JW980_RS03455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW980_RS03465	COG3659	wide pore channel activity
JW980_RS03510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JW980_RS03555	COG0346	lactoylglutathione lyase activity
JW980_RS03560	COG0564	pseudouridine synthase activity
JW980_RS03580	COG3189	MarR family transcriptional regulator
JW980_RS03585	COG2824	Alkylphosphonate utilization operon protein PhnA
JW980_RS03595	COG3422	double-strand break repair
JW980_RS03615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JW980_RS03620	COG0488	(ABC) transporter
JW980_RS03635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JW980_RS03655	COG0730	response to heat
JW980_RS03665	COG1196	nuclear chromosome segregation
JW980_RS03670	COG3115	cell septum assembly
JW980_RS03675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JW980_RS03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JW980_RS03705	COG2193	ferroxidase activity
JW980_RS03710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JW980_RS03715	COG0596	Alpha beta hydrolase
JW980_RS03715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JW980_RS03715	COG2226	methyltransferase
JW980_RS03730	COG4106	trans-aconitate 2-methyltransferase activity
JW980_RS03800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JW980_RS03805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JW980_RS03820	COG0009	L-threonylcarbamoyladenylate synthase
JW980_RS03825	COG3101	peptidyl-lysine hydroxylation
JW980_RS03830	COG1399	metal-binding, possibly nucleic acid-binding protein
JW980_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS03855	COG1652	LysM domain
JW980_RS03860	COG1802	Transcriptional regulator
JW980_RS03865	COG0439	Biotin carboxylase
JW980_RS03905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JW980_RS03915	COG0745	RESPONSE REGULATOR receiver
JW980_RS03920	COG2205	protein histidine kinase activity
JW980_RS03930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW980_RS03950	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JW980_RS03965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW980_RS03975	COG0713	ATP synthesis coupled electron transport
JW980_RS03980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JW980_RS03985	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW980_RS04000	COG1278	Cold shock
JW980_RS04010	COG0583	DNA-binding transcription factor activity
JW980_RS04040	COG0525	valine-tRNA ligase activity
JW980_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS04065	COG0393	Putative heavy-metal-binding
JW980_RS04070	COG1538	Outer membrane efflux protein
JW980_RS04080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW980_RS04085	COG0671	phosphoesterase, PA-phosphatase related
JW980_RS04105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JW980_RS04115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JW980_RS04125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JW980_RS04130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JW980_RS04130	COG1648	precorrin-2 dehydrogenase activity
JW980_RS04135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JW980_RS04155	COG0531	amino acid
JW980_RS04170	COG0321	lipoyl(octanoyl) transferase activity
JW980_RS04175	COG2921	Belongs to the UPF0250 family
JW980_RS04195	COG1280	lysine exporter protein (LysE YggA)
JW980_RS04200	COG0583	DNA-binding transcription factor activity
JW980_RS04210	COG0586	Pfam SNARE associated Golgi protein
JW980_RS04265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JW980_RS04295	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JW980_RS04310	COG0358	DNA primase activity
JW980_RS04320	COG0564	pseudouridine synthase activity
JW980_RS04345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW980_RS04370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JW980_RS04370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JW980_RS04395	COG2072	flavoprotein involved in K transport
JW980_RS04405	COG2009	succinate dehydrogenase
JW980_RS04410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JW980_RS04415	COG1053	succinate dehydrogenase
JW980_RS04420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JW980_RS04435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW980_RS04445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JW980_RS04460	COG2268	Band 7 protein
JW980_RS04465	COG1585	Membrane protein implicated in regulation of membrane protease activity
JW980_RS04475	COG2354	Protein conserved in bacteria
JW980_RS04480	COG2321	neutral zinc metallopeptidase
JW980_RS04510	COG0110	maltose O-acetyltransferase activity
JW980_RS04520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JW980_RS04525	COG0505	Belongs to the CarA family
JW980_RS04550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JW980_RS04555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JW980_RS04595	COG2851	Citrate transporter
JW980_RS04600	COG1253	flavin adenine dinucleotide binding
JW980_RS04630	COG2239	Acts as a magnesium transporter
JW980_RS04645	COG0501	Belongs to the peptidase M48B family
JW980_RS04650	COG0741	lytic transglycosylase activity
JW980_RS04655	COG0037	tRNA processing
JW980_RS04665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JW980_RS04670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JW980_RS04700	COG1309	transcriptional regulator
JW980_RS04715	COG1741	Belongs to the pirin family
JW980_RS04735	COG3739	integral membrane protein
JW980_RS04750	COG3706	GGDEF domain
JW980_RS04760	COG0302	gtp cyclohydrolase
JW980_RS04770	COG0300	oxidoreductase activity
JW980_RS04775	COG0318	PFAM AMP-dependent synthetase and ligase
JW980_RS04785	COG2909	trisaccharide binding
JW980_RS04790	COG0134	indole-3-glycerol-phosphate synthase activity
JW980_RS04795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JW980_RS04800	COG0512	Glutamine amidotransferase of anthranilate synthase
JW980_RS04805	COG0174	glutamine synthetase
JW980_RS04815	COG3161	chorismate lyase activity
JW980_RS04820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JW980_RS04860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JW980_RS04865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JW980_RS04870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JW980_RS04875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JW980_RS04890	COG1115	amino acid carrier protein
JW980_RS04895	COG1113	amino acid transport
JW980_RS04905	COG0019	diaminopimelate decarboxylase activity
JW980_RS04915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JW980_RS04925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JW980_RS04930	COG1522	sequence-specific DNA binding
JW980_RS04935	COG1280	lysine exporter protein (LysE YggA)
JW980_RS04970	COG0842	Transport permease protein
JW980_RS04975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW980_RS04990	COG2175	clavaminate synthase activity
JW980_RS05010	COG0052	Belongs to the universal ribosomal protein uS2 family
JW980_RS05045	COG2951	lytic endotransglycosylase activity
JW980_RS05060	COG0842	Transport permease protein
JW980_RS05065	COG1131	(ABC) transporter
JW980_RS05075	COG0303	'Molybdopterin
JW980_RS05080	COG0315	cyclic pyranopterin monophosphate synthase activity
JW980_RS05080	COG0521	Mo-molybdopterin cofactor biosynthetic process
JW980_RS05090	COG0243	molybdopterin cofactor binding
JW980_RS05095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JW980_RS05105	COG0725	ABC transporter, periplasmic molybdate-binding protein
JW980_RS05110	COG4149	molybdate abc transporter
JW980_RS05170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JW980_RS05195	COG3634	alkyl hydroperoxide reductase activity
JW980_RS05200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW980_RS05205	COG0826	peptidase U32
JW980_RS05265	COG1720	tRNA m6t6A37 methyltransferase activity
JW980_RS05275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JW980_RS05290	COG0642	Histidine kinase
JW980_RS05300	COG0494	nUDIX hydrolase
JW980_RS05310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JW980_RS05315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JW980_RS05320	COG3139	Protein of unknown function (DUF1315)
JW980_RS05335	COG1301	dicarboxylic acid transport
JW980_RS05340	COG1960	acyl-CoA dehydrogenase activity
JW980_RS05345	COG0693	protein deglycase activity
JW980_RS05355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JW980_RS05360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JW980_RS05390	COG0415	Belongs to the DNA photolyase family
JW980_RS05400	COG2252	PERMEase
JW980_RS05405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JW980_RS05415	COG3038	cytochrome b561
JW980_RS05430	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JW980_RS05440	COG0527	aspartate kinase activity
JW980_RS05445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JW980_RS05450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JW980_RS05465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JW980_RS05470	COG1522	sequence-specific DNA binding
JW980_RS05485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JW980_RS05500	COG0667	Aldo Keto reductase
JW980_RS05510	COG1765	OsmC-like protein
JW980_RS05535	COG0540	Belongs to the ATCase OTCase family
JW980_RS05555	COG2031	fatty acid transporter
JW980_RS05560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JW980_RS05575	COG4770	biotin carboxylase activity
JW980_RS05585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JW980_RS05590	COG1960	acyl-CoA dehydrogenase activity
JW980_RS05595	COG1309	transcriptional regulator
JW980_RS05600	COG0318	PFAM AMP-dependent synthetase and ligase
JW980_RS05630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JW980_RS05640	COG0659	secondary active sulfate transmembrane transporter activity
JW980_RS05645	COG0625	glutathione transferase activity
JW980_RS05650	COG2249	NAD(P)H dehydrogenase (quinone) activity
JW980_RS05675	COG2363	Small membrane protein
JW980_RS05690	COG1278	Cold shock
JW980_RS05695	COG0513	Belongs to the DEAD box helicase family
JW980_RS05705	COG0778	Nitroreductase
JW980_RS05730	COG0167	dihydroorotate dehydrogenase activity
JW980_RS05760	COG4783	chaperone-mediated protein folding
JW980_RS05765	COG1610	YqeY-like protein
JW980_RS05795	COG0515	serine threonine protein kinase
JW980_RS05795	COG2815	serine threonine protein kinase
JW980_RS05825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JW980_RS05835	COG1643	Atp-dependent helicase
JW980_RS05855	COG1116	anion transmembrane transporter activity
JW980_RS05855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JW980_RS05865	COG2223	nitrite transmembrane transporter activity
JW980_RS05870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW980_RS05875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW980_RS05880	COG0243	molybdopterin cofactor binding
JW980_RS05890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JW980_RS05925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JW980_RS05930	COG0406	alpha-ribazole phosphatase activity
JW980_RS05940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JW980_RS05940	COG0517	IMP dehydrogenase activity
JW980_RS05945	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JW980_RS05955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JW980_RS05960	COG1137	ATPase activity
JW980_RS05980	COG4122	O-methyltransferase activity
JW980_RS05990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JW980_RS06030	COG2011	ABC-type metal ion transport system permease component
JW980_RS06035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JW980_RS06040	COG1464	Belongs to the NlpA lipoprotein family
JW980_RS06065	COG0151	Belongs to the GarS family
JW980_RS06070	COG0138	bifunctional purine biosynthesis protein purh
JW980_RS06075	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JW980_RS06105	COG0445	tRNA wobble uridine modification
JW980_RS06120	COG2308	Evidence 4 Homologs of previously reported genes of
JW980_RS06130	COG1305	Transglutaminase-like
JW980_RS06145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JW980_RS06150	COG0305	Participates in initiation and elongation during chromosome replication
JW980_RS06165	COG0360	Binds together with S18 to 16S ribosomal RNA
JW980_RS06185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JW980_RS06190	COG1845	cytochrome c oxidase, subunit III
JW980_RS06195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JW980_RS06200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JW980_RS06230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JW980_RS06245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JW980_RS06250	COG2890	protein-(glutamine-N5) methyltransferase activity
JW980_RS06255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JW980_RS06260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JW980_RS06290	COG1960	acyl-CoA dehydrogenase activity
JW980_RS06295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JW980_RS06310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JW980_RS06335	COG0729	surface antigen
JW980_RS06490	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
JW980_RS06550	COG4695	Portal protein
JW980_RS06590	COG3561	AntA/AntB antirepressor
JW980_RS06675	COG3179	chitinase
JW980_RS06740	COG0786	glutamate:sodium symporter activity
JW980_RS06750	COG1113	amino acid transport
JW980_RS06775	COG0024	Methionine aminopeptidase
JW980_RS06780	COG0583	DNA-binding transcription factor activity
JW980_RS06785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JW980_RS06800	COG3852	Histidine kinase
JW980_RS06820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JW980_RS06825	COG0575	Belongs to the CDS family
JW980_RS06840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JW980_RS06860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JW980_RS06885	COG2137	regulation of response to DNA damage stimulus
JW980_RS06890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JW980_RS06895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JW980_RS06900	COG1011	Hydrolase
JW980_RS06940	COG0702	epimerase
JW980_RS06945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JW980_RS06965	COG0446	pyridine nucleotide-disulphide oxidoreductase
JW980_RS06965	COG1902	pentaerythritol trinitrate reductase activity
JW980_RS06980	COG2814	Major facilitator Superfamily
JW980_RS06990	COG0583	DNA-binding transcription factor activity
JW980_RS07010	COG0148	phosphopyruvate hydratase activity
JW980_RS07025	COG0772	Belongs to the SEDS family
JW980_RS07055	COG0579	oxidoreductase
JW980_RS07065	COG1012	belongs to the aldehyde dehydrogenase family
JW980_RS07070	COG1309	transcriptional regulator
JW980_RS07075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JW980_RS07090	COG4890	Cyd operon protein YbgT
JW980_RS07095	COG1294	oxidase, subunit
JW980_RS07110	COG1585	Membrane protein implicated in regulation of membrane protease activity
JW980_RS07120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW980_RS07140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JW980_RS07145	COG0569	domain protein
JW980_RS07155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JW980_RS07160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JW980_RS07185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JW980_RS07190	COG0542	response to heat
JW980_RS07220	COG0372	Belongs to the citrate synthase family
JW980_RS07230	COG2819	hydrolase of the alpha beta superfamily
JW980_RS07235	COG0318	PFAM AMP-dependent synthetase and ligase
JW980_RS07255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JW980_RS07255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JW980_RS07260	COG1254	Belongs to the acylphosphatase family
JW980_RS07265	COG1047	Peptidyl-prolyl cis-trans
JW980_RS07270	COG1252	NADH dehydrogenase
JW980_RS07275	COG1686	Belongs to the peptidase S11 family
JW980_RS07285	COG2351	hydroxyisourate hydrolase activity
JW980_RS07310	COG1131	(ABC) transporter
JW980_RS07315	COG0842	Transport permease protein
JW980_RS07320	COG0842	Transport permease protein
JW980_RS07345	COG1309	transcriptional regulator
JW980_RS07410	COG1278	Cold shock
JW980_RS07490	COG1230	cation diffusion facilitator family transporter
JW980_RS07495	COG1937	Protein conserved in bacteria
JW980_RS07535	COG2814	Major facilitator Superfamily
JW980_RS07540	COG1238	metal cluster binding
JW980_RS07580	COG2826	transposase and inactivated derivatives, IS30 family
JW980_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW980_RS07600	COG0842	Transport permease protein
JW980_RS07600	COG1129	ABC transporter
JW980_RS07605	COG0842	Transport permease protein
JW980_RS07655	COG2070	2-Nitropropane dioxygenase
JW980_RS07680	COG3634	alkyl hydroperoxide reductase activity
JW980_RS07700	COG0436	Aminotransferase
JW980_RS07705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW980_RS07710	COG0386	Belongs to the glutathione peroxidase family
JW980_RS07735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JW980_RS07750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JW980_RS07775	COG0012	GTP binding
JW980_RS07785	COG2011	ABC-type metal ion transport system permease component
JW980_RS07790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JW980_RS07795	COG1464	Belongs to the NlpA lipoprotein family
JW980_RS07800	COG1464	Belongs to the NlpA lipoprotein family
JW980_RS07840	COG0204	Acyl-transferase
JW980_RS07855	COG0582	viral genome integration into host DNA
JW980_RS07870	COG2801	Transposase and inactivated derivatives
JW980_RS07945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JW980_RS07950	COG0730	response to heat
JW980_RS07970	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JW980_RS07975	COG1944	ATP diphosphatase activity
JW980_RS07980	COG2207	Transcriptional regulator
JW980_RS07985	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JW980_RS07990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JW980_RS08020	COG2223	nitrite transmembrane transporter activity
JW980_RS08035	COG1346	cytolysis
JW980_RS08040	COG1380	Effector of murein hydrolase LrgA
JW980_RS08045	COG0583	DNA-binding transcription factor activity
JW980_RS08050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JW980_RS08235	COG5410	chromosome segregation
JW980_RS08240	COG3567	Phage-associated protein, HI1409 family
JW980_RS08245	COG2369	cell adhesion
JW980_RS08365	COG3772	lysozyme
JW980_RS08380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JW980_RS08465	COG3300	MHYT domain
JW980_RS08465	COG5001	Diguanylate cyclase
JW980_RS08470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JW980_RS08495	COG1132	(ABC) transporter
JW980_RS08505	COG0668	transmembrane transport
JW980_RS08510	COG3122	Protein conserved in bacteria
JW980_RS08530	COG0640	Transcriptional regulator
JW980_RS08535	COG0596	Alpha beta hydrolase
JW980_RS08540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JW980_RS08545	COG1335	isochorismatase
JW980_RS08550	COG0251	oxidation-reduction process
JW980_RS08555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JW980_RS08560	COG2233	PERMEase
JW980_RS08570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JW980_RS08580	COG0183	Belongs to the thiolase family
JW980_RS08585	COG0583	DNA-binding transcription factor activity
JW980_RS08600	COG0439	Biotin carboxylase
JW980_RS08615	COG0511	ligase activity, forming carbon-carbon bonds
JW980_RS08635	COG4829	muconolactone delta-isomerase
JW980_RS08640	COG4948	Mandelate Racemase Muconate Lactonizing
JW980_RS08650	COG2814	Major facilitator Superfamily
JW980_RS08745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JW980_RS08750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JW980_RS08755	COG0022	dehydrogenase e1 component
JW980_RS08760	COG0508	dehydrogenase complex catalyzes the overall conversion of
JW980_RS08765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW980_RS08775	COG1063	alcohol dehydrogenase
JW980_RS08780	COG4628	conserved protein (DUF2132)
JW980_RS09155	COG0596	Alpha beta hydrolase
JW980_RS09225	COG0864	Transcriptional regulator
JW980_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS09250	COG2814	Major facilitator Superfamily
JW980_RS09260	COG2199	diguanylate cyclase activity
JW980_RS09305	COG1960	acyl-CoA dehydrogenase activity
JW980_RS09310	COG1960	acyl-CoA dehydrogenase activity
JW980_RS09360	COG0552	protein localization to endoplasmic reticulum
JW980_RS09365	COG0612	Peptidase, M16
JW980_RS09390	COG0517	IMP dehydrogenase activity
JW980_RS09395	COG0133	tryptophan synthase activity
JW980_RS09405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JW980_RS09420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JW980_RS09425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JW980_RS09465	COG0537	adenosine 5'-monophosphoramidase activity
JW980_RS09490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW980_RS09495	COG0776	regulation of translation
JW980_RS09510	COG1959	2 iron, 2 sulfur cluster binding
JW980_RS09520	COG0822	iron-sulfur transferase activity
JW980_RS09525	COG0316	Belongs to the HesB IscA family
JW980_RS09555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JW980_RS09565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JW980_RS09605	COG3781	membrane
JW980_RS09610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JW980_RS09620	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JW980_RS09640	COG0697	spore germination
JW980_RS09655	COG0126	phosphoglycerate kinase activity
JW980_RS09665	COG0424	maF-like protein
JW980_RS09675	COG2850	peptidyl-arginine hydroxylation
JW980_RS09680	COG4585	Histidine kinase
JW980_RS09685	COG2197	response regulator
JW980_RS09690	COG0069	glutamate synthase activity
JW980_RS09710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JW980_RS09715	COG1454	alcohol dehydrogenase
JW980_RS09720	COG0824	Thioesterase
JW980_RS09725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JW980_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS09750	COG0183	Belongs to the thiolase family
JW980_RS09800	COG0583	DNA-binding transcription factor activity
JW980_RS09805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JW980_RS09815	COG3135	benzoate transporter
JW980_RS09820	COG1309	transcriptional regulator
JW980_RS09825	COG2076	Multidrug Resistance protein
JW980_RS09840	COG0589	response to stress
JW980_RS09850	COG0308	aminopeptidase N
JW980_RS09875	COG1253	flavin adenine dinucleotide binding
JW980_RS09895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JW980_RS09900	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JW980_RS09915	COG2431	L-lysine efflux transmembrane transporter activity
JW980_RS09930	COG0776	regulation of translation
JW980_RS09950	COG0590	tRNA wobble adenosine to inosine editing
JW980_RS09960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JW980_RS09980	COG2165	general secretion pathway protein
JW980_RS09995	COG0084	hydrolase, TatD family'
JW980_RS10015	COG1663	tetraacyldisaccharide 4'-kinase activity
JW980_RS10020	COG1132	(ABC) transporter
JW980_RS10030	COG0811	peptide transport
JW980_RS10035	COG1475	DNA binding
JW980_RS10040	COG1192	Involved in chromosome partitioning
JW980_RS10050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JW980_RS10055	COG3178	'Phosphotransferase
JW980_RS10065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW980_RS10070	COG1923	regulation of RNA biosynthetic process
JW980_RS10080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JW980_RS10085	COG0802	atpase or kinase
JW980_RS10110	COG2707	UPF0756 membrane protein
JW980_RS10115	COG2814	Major facilitator Superfamily
JW980_RS10120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JW980_RS10125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JW980_RS10135	COG1454	alcohol dehydrogenase
JW980_RS10155	COG0531	amino acid
JW980_RS10160	COG4303	Ethanolamine ammonia lyase large subunit
JW980_RS10165	COG4302	ethanolamine ammonia-lyase activity
JW980_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS10185	COG0519	Catalyzes the synthesis of GMP from XMP
JW980_RS10185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JW980_RS10190	COG2353	YceI-like domain
JW980_RS10195	COG0456	acetyltransferase
JW980_RS10205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JW980_RS10210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JW980_RS10255	COG0352	thiamine-phosphate diphosphorylase activity
JW980_RS10290	COG0612	Peptidase, M16
JW980_RS10300	COG1823	symporter activity
JW980_RS10305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JW980_RS10375	COG0714	Associated with various cellular activities
JW980_RS10380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JW980_RS10385	COG2879	small protein
JW980_RS10390	COG1966	Carbon starvation protein
JW980_RS10395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JW980_RS10420	COG0254	rRNA binding
JW980_RS10440	COG1067	ATP-dependent peptidase activity
JW980_RS10445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JW980_RS10450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JW980_RS10455	COG0616	signal peptide processing
JW980_RS10460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JW980_RS10470	COG0573	inorganic phosphate transmembrane transporter activity
JW980_RS10475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JW980_RS10480	COG0076	glutamate decarboxylase activity
JW980_RS10485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JW980_RS10495	COG4772	TonB-dependent receptor
JW980_RS10500	COG0671	phosphoesterase, PA-phosphatase related
JW980_RS10505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JW980_RS10515	COG1733	regulation of RNA biosynthetic process
JW980_RS10520	COG0702	epimerase
JW980_RS10555	COG0556	nucleotide-excision repair
JW980_RS10575	COG0436	Aminotransferase
JW980_RS10610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JW980_RS10615	COG1381	Involved in DNA repair and RecF pathway recombination
JW980_RS10625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JW980_RS10640	COG0681	Belongs to the peptidase S26 family
JW980_RS10660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JW980_RS10680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JW980_RS10690	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JW980_RS10705	COG4208	sulfate ABC transporter
JW980_RS10710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JW980_RS10715	COG0583	DNA-binding transcription factor activity
JW980_RS10735	COG0602	queuosine metabolic process
JW980_RS10740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JW980_RS10755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JW980_RS10765	COG0583	DNA-binding transcription factor activity
JW980_RS10770	COG2353	YceI-like domain
JW980_RS10775	COG1056	cytidyltransferase-related domain
JW980_RS10775	COG1051	belongs to the nudix hydrolase family
JW980_RS10780	COG1024	Enoyl-CoA hydratase
JW980_RS10785	COG0778	Nitroreductase
JW980_RS10790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JW980_RS10790	COG3323	Protein of unknown function (DUF1653)
JW980_RS10800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JW980_RS10800	COG0047	phosphoribosylformylglycinamidine synthase activity
JW980_RS10815	COG2255	four-way junction helicase activity
JW980_RS10820	COG0824	Thioesterase
JW980_RS10840	COG0823	Involved in the tonB-independent uptake of proteins
JW980_RS10860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JW980_RS10905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JW980_RS10910	COG0628	permease
JW980_RS10915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JW980_RS10920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JW980_RS10940	COG0658	competence protein
JW980_RS10940	COG2333	competence protein COMEC
JW980_RS10945	COG1136	(ABC) transporter
JW980_RS10950	COG4591	ABC-type transport system involved in lipoprotein release permease component
JW980_RS10965	COG1671	Belongs to the UPF0178 family
JW980_RS10980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW980_RS10985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JW980_RS10990	COG1960	acyl-CoA dehydrogenase activity
JW980_RS11035	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JW980_RS11040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JW980_RS11045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JW980_RS11050	COG5001	Diguanylate cyclase
JW980_RS11050	COG1716	ATPase activity
JW980_RS11055	COG0281	malic enzyme
JW980_RS11055	COG0280	phosphate acetyltransferase
JW980_RS11085	COG0446	pyridine nucleotide-disulphide oxidoreductase
JW980_RS11085	COG1902	pentaerythritol trinitrate reductase activity
JW980_RS11090	COG0277	FAD linked oxidase domain protein
JW980_RS11100	COG2186	Transcriptional regulator
JW980_RS11115	COG5001	Diguanylate cyclase
JW980_RS11115	COG2203	Gaf domain
JW980_RS11115	COG3706	GGDEF domain
JW980_RS11115	COG4251	negative regulation of phosphorylation
JW980_RS11120	COG0418	dihydroorotase activity
JW980_RS11125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JW980_RS11150	COG0833	amino acid
JW980_RS11225	COG0582	viral genome integration into host DNA
JW980_RS11230	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
JW980_RS11245	COG4172	Belongs to the ABC transporter superfamily
JW980_RS11250	COG4239	(ABC) transporter, permease
JW980_RS11255	COG4174	ABC transporter (Permease)
JW980_RS11260	COG4166	transmembrane transport
JW980_RS11265	COG1388	LysM domain
JW980_RS11265	COG0741	lytic transglycosylase activity
JW980_RS11270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JW980_RS11280	COG2816	NAD+ diphosphatase activity
JW980_RS11285	COG0657	acetylesterase activity
JW980_RS11305	COG0583	DNA-binding transcription factor activity
JW980_RS11325	COG0753	catalase activity
JW980_RS11345	COG1686	Belongs to the peptidase S11 family
JW980_RS11350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JW980_RS11370	COG2915	High frequency lysogenization protein hflD homolog
JW980_RS11390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JW980_RS11395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JW980_RS11420	COG0006	proline dipeptidase activity
JW980_RS11485	COG1785	Belongs to the alkaline phosphatase family
JW980_RS11490	COG1785	Belongs to the alkaline phosphatase family
JW980_RS11500	COG4770	biotin carboxylase activity
JW980_RS11520	COG1914	H( )-stimulated, divalent metal cation uptake system
JW980_RS11525	COG0583	DNA-binding transcription factor activity
JW980_RS11530	COG2217	Heavy metal translocating P-type atpase
JW980_RS11540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JW980_RS11555	COG2234	aminopeptidase activity
JW980_RS11565	COG3384	dioxygenase
JW980_RS11575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JW980_RS11580	COG2878	Part of a membrane complex involved in electron transport
JW980_RS11585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JW980_RS11610	COG0768	penicillin binding
JW980_RS11615	COG0742	ribosomal rna small subunit methyltransferase
JW980_RS11660	COG1597	lipid kinase activity
JW980_RS11680	COG0477	Major facilitator Superfamily
JW980_RS11720	COG3321	synthase
JW980_RS11720	COG4221	oxidoreductase activity
JW980_RS11720	COG0604	alcohol dehydrogenase
JW980_RS11720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JW980_RS11735	COG1695	Transcriptional regulator
JW980_RS11770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JW980_RS11775	COG1773	rubredoxin
JW980_RS11780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW980_RS11790	COG0583	DNA-binding transcription factor activity
JW980_RS11810	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JW980_RS11815	COG4181	ATPase activity
JW980_RS11865	COG0306	phosphate transporter
JW980_RS11875	COG2223	nitrite transmembrane transporter activity
JW980_RS11880	COG2207	Transcriptional regulator
JW980_RS11885	COG0242	peptide deformylase activity
JW980_RS11930	COG0456	acetyltransferase
JW980_RS11945	COG4681	YaeQ
JW980_RS11950	COG0523	cobalamin synthesis protein
JW980_RS11960	COG1607	acyl-coa hydrolase
JW980_RS11965	COG1752	Esterase of the alpha-beta hydrolase superfamily
JW980_RS11975	COG1115	amino acid carrier protein
JW980_RS11980	COG0786	glutamate:sodium symporter activity
JW980_RS11995	COG2814	Major facilitator Superfamily
JW980_RS12000	COG1289	transmembrane transporter activity
JW980_RS12010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JW980_RS12080	COG2832	Protein of unknown function (DUF454)
JW980_RS12095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JW980_RS12105	COG0784	Response regulator, receiver
JW980_RS12105	COG0643	Histidine kinase
JW980_RS12105	COG2198	Histidine kinase
JW980_RS12110	COG0840	transmembrane signaling receptor activity
JW980_RS12180	COG2358	TRAP transporter, solute receptor (TAXI family
JW980_RS12195	COG0489	protein tyrosine kinase activity
JW980_RS12220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW980_RS12220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW980_RS12240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JW980_RS12270	COG4716	Myosin-crossreactive antigen
JW980_RS12300	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JW980_RS12305	COG2081	HI0933 family
JW980_RS12320	COG0668	transmembrane transport
JW980_RS12340	COG0765	amino acid transport
JW980_RS12345	COG0765	amino acid transport
JW980_RS12350	COG1126	abc transporter atp-binding protein
JW980_RS12360	COG0004	ammonium transporteR
JW980_RS12375	COG0642	Histidine kinase
JW980_RS12380	COG0745	RESPONSE REGULATOR receiver
JW980_RS12405	COG1752	Esterase of the alpha-beta hydrolase superfamily
JW980_RS12420	COG0142	geranyltranstransferase activity
JW980_RS12425	COG2828	Protein conserved in bacteria
JW980_RS12430	COG1113	amino acid transport
JW980_RS12435	COG3293	Transposase
JW980_RS12455	COG1113	amino acid transport
JW980_RS12475	COG0625	glutathione transferase activity
JW980_RS12490	COG0431	NADPH-dependent FMN reductase
JW980_RS12495	COG0798	PFAM Bile acid sodium symporter
JW980_RS12505	COG0640	Transcriptional regulator
JW980_RS12555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JW980_RS12570	COG0424	maF-like protein
JW980_RS12575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JW980_RS12580	COG1792	Involved in formation and maintenance of cell shape
JW980_RS12585	COG1077	Cell shape determining protein MreB Mrl
JW980_RS12590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JW980_RS12600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JW980_RS12610	COG0693	protein deglycase activity
JW980_RS12630	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
JW980_RS12645	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS12650	COG2610	gluconate transmembrane transporter activity
JW980_RS12655	COG0583	DNA-binding transcription factor activity
JW980_RS12665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JW980_RS12675	COG4772	TonB-dependent receptor
JW980_RS12680	COG4993	Dehydrogenase
JW980_RS12690	COG1012	belongs to the aldehyde dehydrogenase family
JW980_RS12695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JW980_RS12705	COG1113	amino acid transport
JW980_RS12715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW980_RS12725	COG1346	cytolysis
JW980_RS12745	COG1522	sequence-specific DNA binding
JW980_RS12760	COG2130	NADP-dependent
JW980_RS12765	COG1309	transcriptional regulator
JW980_RS12775	COG1902	pentaerythritol trinitrate reductase activity
JW980_RS12785	COG1979	alcohol dehydrogenase
JW980_RS12795	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JW980_RS12810	COG0604	alcohol dehydrogenase
JW980_RS12810	COG3321	synthase
JW980_RS12815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JW980_RS12820	COG0583	DNA-binding transcription factor activity
JW980_RS12825	COG4221	oxidoreductase activity
JW980_RS12900	COG4969	Belongs to the N-Me-Phe pilin family
JW980_RS12975	COG0642	Histidine kinase
JW980_RS12990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JW980_RS13040	COG2816	NAD+ diphosphatase activity
JW980_RS13045	COG3046	protein related to deoxyribodipyrimidine photolyase
JW980_RS13060	COG2351	hydroxyisourate hydrolase activity
JW980_RS13090	COG2323	membrane
JW980_RS13110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JW980_RS13130	COG1335	isochorismatase
JW980_RS13170	COG3177	Filamentation induced by cAMP protein fic
JW980_RS13175	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JW980_RS13230	COG3177	Filamentation induced by cAMP protein fic
JW980_RS13250	COG0531	amino acid
JW980_RS13265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JW980_RS13270	COG0582	viral genome integration into host DNA
JW980_RS13280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JW980_RS13285	COG2814	Major facilitator Superfamily
JW980_RS13290	COG1566	PFAM secretion protein HlyD family protein
JW980_RS13295	COG2050	protein possibly involved in aromatic compounds catabolism
JW980_RS13310	COG1090	epimerase
JW980_RS13320	COG2203	Gaf domain
JW980_RS13320	COG4251	negative regulation of phosphorylation
JW980_RS13320	COG5001	Diguanylate cyclase
JW980_RS13320	COG3706	GGDEF domain
JW980_RS13325	COG0420	3'-5' exonuclease activity
JW980_RS13355	COG0735	belongs to the Fur family
JW980_RS13360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JW980_RS13365	COG2914	Belongs to the UPF0125 (RnfH) family
JW980_RS13380	COG0121	glutamine amidotransferase
JW980_RS13395	COG0756	dUTP diphosphatase activity
JW980_RS13400	COG0210	DNA helicase
JW980_RS13405	COG2885	chlorophyll binding
JW980_RS13410	COG0204	Acyl-transferase
JW980_RS13420	COG0850	regulation of cytokinetic process
JW980_RS13425	COG2894	cell division
JW980_RS13430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JW980_RS13445	COG0531	amino acid
JW980_RS13445	COG1674	ftsk spoiiie
JW980_RS13450	COG0492	ferredoxin-NADP+ reductase activity
JW980_RS13455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JW980_RS13465	COG0456	acetyltransferase
JW980_RS13490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JW980_RS13505	COG1981	membrane
JW980_RS13515	COG1113	amino acid transport
JW980_RS13520	COG0251	oxidation-reduction process
JW980_RS13550	COG0351	phosphomethylpyrimidine kinase
JW980_RS13550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JW980_RS13550	COG0352	thiamine-phosphate diphosphorylase activity
JW980_RS13560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JW980_RS13585	COG2132	Multicopper oxidase
JW980_RS13595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JW980_RS13630	COG1968	undecaprenyl-diphosphatase activity
JW980_RS13635	COG1214	PFAM Peptidase M22, glycoprotease
JW980_RS13640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JW980_RS13645	COG0494	nUDIX hydrolase
JW980_RS13665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JW980_RS13675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JW980_RS13700	COG0693	protein deglycase activity
JW980_RS13745	COG2853	Lipoprotein
JW980_RS13750	COG2208	phosphoserine phosphatase activity
JW980_RS13760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JW980_RS13765	COG1764	response to oxidative stress
JW980_RS13800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW980_RS13800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW980_RS13815	COG0037	tRNA processing
JW980_RS13825	COG0248	Ppx GppA phosphatase
JW980_RS13850	COG0072	phenylalanine-tRNA ligase activity
JW980_RS13905	COG1238	metal cluster binding
JW980_RS13915	COG0625	glutathione transferase activity
JW980_RS13935	COG0318	PFAM AMP-dependent synthetase and ligase
JW980_RS13940	COG3028	Belongs to the UPF0307 family
JW980_RS13950	COG1660	Displays ATPase and GTPase activities
JW980_RS13955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JW980_RS13965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JW980_RS13970	COG0617	tRNA 3'-terminal CCA addition
JW980_RS13975	COG1555	photosystem II stabilization
JW980_RS13980	COG3956	TIGRFAM MazG family protein
JW980_RS13990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JW980_RS14005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JW980_RS14010	COG5002	protein histidine kinase activity
JW980_RS14010	COG0784	Response regulator, receiver
JW980_RS14010	COG2205	protein histidine kinase activity
JW980_RS14015	COG1024	Enoyl-CoA hydratase
JW980_RS14020	COG2084	Dehydrogenase
JW980_RS14025	COG3622	Belongs to the hyi family
JW980_RS14040	COG0004	ammonium transporteR
JW980_RS14065	COG2814	Major facilitator Superfamily
JW980_RS14085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JW980_RS14095	COG0732	type I restriction modification DNA specificity domain
JW980_RS14105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JW980_RS14120	COG0174	glutamine synthetase
JW980_RS14135	COG0745	RESPONSE REGULATOR receiver
JW980_RS14140	COG2205	protein histidine kinase activity
JW980_RS14150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JW980_RS14155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JW980_RS14250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JW980_RS14265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JW980_RS14275	COG0084	hydrolase, TatD family'
JW980_RS14290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JW980_RS14300	COG0793	Belongs to the peptidase S41A family
JW980_RS14315	COG2267	carboxylic ester hydrolase activity
JW980_RS14320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JW980_RS14325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JW980_RS14330	COG0857	belongs to the CobB CobQ family
JW980_RS14330	COG0280	phosphate acetyltransferase
JW980_RS14345	COG2318	DinB family
JW980_RS14350	COG0697	spore germination
JW980_RS14355	COG2207	Transcriptional regulator
JW980_RS14355	COG1917	Cupin 2, conserved barrel domain protein
JW980_RS14365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JW980_RS14365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JW980_RS14385	COG0740	serine-type endopeptidase activity
JW980_RS14395	COG4771	TonB-dependent receptor
JW980_RS14400	COG4774	siderophore transport
JW980_RS14415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JW980_RS14425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JW980_RS14425	COG2813	Specifically methylates the guanine in position
JW980_RS14530	COG0788	formyltetrahydrofolate deformylase activity
JW980_RS14555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JW980_RS14555	COG4651	solute:proton antiporter activity
JW980_RS14580	COG0210	DNA helicase
JW980_RS14585	COG1929	Belongs to the glycerate kinase type-1 family
JW980_RS14625	COG2900	Belongs to the SlyX family
JW980_RS14630	COG0488	(ABC) transporter
JW980_RS14635	COG1560	Kdo2-lipid A biosynthetic process
JW980_RS14690	COG0473	3-isopropylmalate dehydrogenase activity
JW980_RS14705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JW980_RS14715	COG0583	DNA-binding transcription factor activity
JW980_RS14750	COG1280	lysine exporter protein (LysE YggA)
JW980_RS14780	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JW980_RS14795	COG0583	DNA-binding transcription factor activity
JW980_RS14810	COG0564	pseudouridine synthase activity
JW980_RS14815	COG1530	ribonuclease E activity
JW980_RS14820	COG0318	PFAM AMP-dependent synthetase and ligase
JW980_RS14845	COG1983	PspC domain protein
JW980_RS14870	COG0751	glycine-tRNA ligase activity
JW980_RS14895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JW980_RS14910	COG2226	methyltransferase
JW980_RS14925	COG0493	'glutamate synthase
JW980_RS14925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW980_RS14935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JW980_RS14950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JW980_RS14955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JW980_RS14965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JW980_RS14975	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
JW980_RS14975	COG0644	oxidoreductase
JW980_RS14985	COG0425	Belongs to the sulfur carrier protein TusA family
JW980_RS14990	COG4535	Mg2 and Co2 transporter CorC
JW980_RS14995	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JW980_RS15000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW980_RS15020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JW980_RS15030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JW980_RS15050	COG2841	Protein conserved in bacteria
JW980_RS15055	COG0598	Magnesium transport protein CorA
JW980_RS15060	COG1185	polyribonucleotide nucleotidyltransferase activity
JW980_RS15070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JW980_RS15075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JW980_RS15080	COG1074	ATP-dependent DNA helicase activity
JW980_RS15085	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JW980_RS15115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JW980_RS15135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JW980_RS15145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JW980_RS15150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JW980_RS15150	COG2111	Na H antiporter
JW980_RS15155	COG1006	Multisubunit Na H antiporter MnhC subunit
JW980_RS15160	COG0651	ATP synthesis coupled electron transport
JW980_RS15165	COG1863	multisubunit Na H antiporter MnhE subunit
JW980_RS15170	COG2212	antiporter activity
JW980_RS15175	COG1320	monovalent cation:proton antiporter activity
JW980_RS15180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JW980_RS15190	COG0195	Participates in both transcription termination and antitermination
JW980_RS15250	COG0237	dephospho-CoA kinase activity
JW980_RS15260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JW980_RS15270	COG0497	DNA recombination
JW980_RS15275	COG1678	Uncharacterized ACR, COG1678
JW980_RS15280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JW980_RS15295	COG1289	transmembrane transporter activity
JW980_RS15310	COG1132	(ABC) transporter
JW980_RS15315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JW980_RS15385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JW980_RS15415	COG0326	Molecular chaperone. Has ATPase activity
JW980_RS15425	COG3047	cAMP biosynthetic process
JW980_RS15430	COG2056	Na+-H+ antiporter family
JW980_RS15455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JW980_RS15460	COG0085	RNA polymerase activity
JW980_RS15465	COG0222	ribosome binding
JW980_RS15470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JW980_RS15475	COG0081	regulation of translation
JW980_RS15480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JW980_RS15530	COG0546	phosphoglycolate phosphatase activity
JW980_RS15560	COG0824	Thioesterase
JW980_RS15580	COG0181	hydroxymethylbilane synthase activity
JW980_RS15590	COG3275	phosphorelay sensor kinase activity
JW980_RS15610	COG1538	Outer membrane efflux protein
JW980_RS15620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JW980_RS15630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JW980_RS15635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JW980_RS15640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JW980_RS15645	COG0772	Belongs to the SEDS family
JW980_RS15650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JW980_RS15670	COG4974	Belongs to the 'phage' integrase family
JW980_RS15675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JW980_RS15685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JW980_RS15690	COG1686	Belongs to the peptidase S11 family
JW980_RS15695	COG2197	response regulator
JW980_RS15710	COG0793	Belongs to the peptidase S41A family
JW980_RS15715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JW980_RS15720	COG0795	lipopolysaccharide-transporting ATPase activity
JW980_RS15725	COG0795	lipopolysaccharide-transporting ATPase activity
JW980_RS15745	COG0586	Pfam SNARE associated Golgi protein
JW980_RS15760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JW980_RS15760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JW980_RS15770	COG0004	ammonium transporteR
JW980_RS15775	COG0347	Belongs to the P(II) protein family
JW980_RS15785	COG0606	chelatase, subunit chli
JW980_RS15805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JW980_RS15820	COG0318	PFAM AMP-dependent synthetase and ligase
JW980_RS15830	COG0477	Major facilitator Superfamily
JW980_RS15835	COG2860	membrane
JW980_RS15840	COG3012	SEC-C Motif Domain Protein
JW980_RS15845	COG1253	flavin adenine dinucleotide binding
JW980_RS15875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JW980_RS15950	COG0758	DNA mediated transformation
JW980_RS15960	COG0697	spore germination
JW980_RS15970	COG0386	Belongs to the glutathione peroxidase family
JW980_RS16005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JW980_RS16055	COG1121	(ABC) transporter
JW980_RS16060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JW980_RS16065	COG1683	Conserved Protein
JW980_RS16075	COG2837	iron assimilation
JW980_RS16085	COG5632	N-Acetylmuramoyl-L-alanine amidase
JW980_RS16085	COG3409	Peptidoglycan-binding domain 1 protein
JW980_RS16085	COG1388	LysM domain
JW980_RS16095	COG0281	malic enzyme
JW980_RS16150	COG0519	Catalyzes the synthesis of GMP from XMP
JW980_RS16150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JW980_RS16160	COG2259	Doxx family
JW980_RS16165	COG0586	Pfam SNARE associated Golgi protein
JW980_RS16180	COG1192	Involved in chromosome partitioning
JW980_RS16190	COG0271	Belongs to the BolA IbaG family
JW980_RS16365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JW980_RS16370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JW980_RS16370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JW980_RS16370	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JW980_RS16375	COG1105	Belongs to the carbohydrate kinase PfkB family
JW980_RS16380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JW980_RS16380	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW980_RS16390	COG2986	histidine ammonia-lyase
JW980_RS16405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JW980_RS16415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JW980_RS16435	COG0583	DNA-binding transcription factor activity
JW980_RS16440	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JW980_RS16455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JW980_RS16465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JW980_RS16470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JW980_RS16480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JW980_RS16525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JW980_RS16540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JW980_RS16545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JW980_RS16550	COG1216	Glycosyl transferase, family 2
JW980_RS16580	COG2030	dehydratase
JW980_RS16595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JW980_RS16610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JW980_RS16620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JW980_RS16625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JW980_RS16630	COG0438	transferase activity, transferring glycosyl groups
JW980_RS16635	COG0438	transferase activity, transferring glycosyl groups
JW980_RS16640	COG0438	transferase activity, transferring glycosyl groups
JW980_RS16665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JW980_RS16695	COG0728	peptidoglycan biosynthetic process
JW980_RS16700	COG3023	N-Acetylmuramoyl-L-alanine amidase
JW980_RS16710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JW980_RS16720	COG3307	-O-antigen
JW980_RS16725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JW980_RS16730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JW980_RS16735	COG0546	phosphoglycolate phosphatase activity
JW980_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
JW980_RS16765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JW980_RS16765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JW980_RS16770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JW980_RS16775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JW980_RS16780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JW980_RS16785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JW980_RS16790	COG1116	anion transmembrane transporter activity
JW980_RS16795	COG1309	transcriptional regulator
JW980_RS16810	COG0196	riboflavin kinase activity
JW980_RS16815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JW980_RS16820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JW980_RS16825	COG1047	Peptidyl-prolyl cis-trans
JW980_RS16840	COG2133	pyrroloquinoline quinone binding
JW980_RS16870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JW980_RS16875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JW980_RS16880	COG2951	lytic endotransglycosylase activity
JW980_RS16885	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JW980_RS16900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JW980_RS16920	COG0861	Integral membrane protein TerC family
JW980_RS16930	COG0754	glutathionylspermidine amidase activity
JW980_RS16940	COG0402	S-adenosylhomocysteine deaminase activity
JW980_RS16960	COG1230	cation diffusion facilitator family transporter
JW980_RS16980	COG0629	single-stranded DNA binding
JW980_RS17010	COG0582	viral genome integration into host DNA
JW980_RS17020	COG0706	membrane insertase activity
JW980_RS17025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JW980_RS17045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW980_RS17060	COG2009	succinate dehydrogenase
JW980_RS17070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JW980_RS17080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JW980_RS17115	COG0625	glutathione transferase activity
JW980_RS17120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW980_RS17190	COG4680	protein conserved in bacteria
JW980_RS17195	COG1373	ATPase (AAA superfamily
JW980_RS17205	COG0582	viral genome integration into host DNA
JW980_RS17280	COG4977	sequence-specific DNA binding
JW980_RS17280	COG1917	Cupin 2, conserved barrel domain protein
JW980_RS17285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW980_RS17305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW980_RS17310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW980_RS17325	COG0251	oxidation-reduction process
JW980_RS17335	COG3158	transport of potassium into the cell
JW980_RS17365	COG1764	response to oxidative stress
JW980_RS17370	COG1846	Transcriptional regulator
JW980_RS17385	COG3842	ATPase activity
JW980_RS17390	COG1840	ABC-type Fe3 transport system, periplasmic component
JW980_RS17405	COG3335	DDE superfamily endonuclease
JW980_RS17435	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JW980_RS17455	COG0604	alcohol dehydrogenase
JW980_RS17475	COG1063	alcohol dehydrogenase
JW980_RS17490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JW980_RS17565	COG0515	serine threonine protein kinase
JW980_RS17570	COG2116	formate transmembrane transporter activity
JW980_RS17600	COG1192	Involved in chromosome partitioning
JW980_RS17605	COG1475	DNA binding
JW980_RS17625	COG2814	Major facilitator Superfamily
JW980_RS17640	COG2026	Addiction module toxin, RelE StbE family
JW980_RS17645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JW980_RS17665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JW980_RS17690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JW980_RS17695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JW980_RS17760	COG0789	Transcriptional regulator
JW980_RS17810	COG2217	Heavy metal translocating P-type atpase
JW980_RS17815	COG3174	membrane
JW980_RS17820	COG2205	protein histidine kinase activity
JW980_RS17835	COG2132	Multicopper oxidase