locus-tag	class	description
ABCA12_RS00025	COG0187	DNA topoisomerase II activity
ABCA12_RS00035	COG0586	Pfam SNARE associated Golgi protein
ABCA12_RS00040	COG0488	(ABC) transporter
ABCA12_RS00075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ABCA12_RS00080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ABCA12_RS00130	COG0733	neurotransmitter:sodium symporter activity
ABCA12_RS00165	COG2233	PERMEase
ABCA12_RS00175	COG1309	transcriptional regulator
ABCA12_RS00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_RS00210	COG2814	Major facilitator Superfamily
ABCA12_RS00215	COG0656	L-ascorbic acid biosynthetic process
ABCA12_RS00220	COG0583	DNA-binding transcription factor activity
ABCA12_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABCA12_RS00235	COG1064	alcohol dehydrogenase
ABCA12_RS00240	COG2818	Glycosylase
ABCA12_RS00250	COG0739	heme binding
ABCA12_RS00265	COG5487	UPF0391 membrane protein
ABCA12_RS00270	COG2983	Belongs to the UPF0260 family
ABCA12_RS00275	COG2133	pyrroloquinoline quinone binding
ABCA12_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ABCA12_RS00300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ABCA12_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ABCA12_RS00315	COG1335	isochorismatase
ABCA12_RS00330	COG4372	Transposase
ABCA12_RS00375	COG2963	transposase activity
ABCA12_RS00410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ABCA12_RS00420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ABCA12_RS00425	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ABCA12_RS00430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ABCA12_RS00450	COG0560	Phosphoserine phosphatase
ABCA12_RS00450	COG3830	Belongs to the UPF0237 family
ABCA12_RS00490	COG0583	DNA-binding transcription factor activity
ABCA12_RS00525	COG0534	Mate efflux family protein
ABCA12_RS00530	COG0436	Aminotransferase
ABCA12_RS00540	COG2733	membrane
ABCA12_RS00555	COG2918	glutathione biosynthetic process
ABCA12_RS00570	COG1705	Flagellar rod assembly protein muramidase FlgJ
ABCA12_RS00570	COG1388	LysM domain
ABCA12_RS00600	COG3150	esterase
ABCA12_RS00610	COG0534	Mate efflux family protein
ABCA12_RS00645	COG1247	-acetyltransferase
ABCA12_RS00695	COG1393	Belongs to the ArsC family
ABCA12_RS00700	COG0708	Exodeoxyribonuclease III
ABCA12_RS00760	COG1846	Transcriptional regulator
ABCA12_RS00765	COG0386	Belongs to the glutathione peroxidase family
ABCA12_RS00770	COG0189	ligase activity
ABCA12_RS00790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ABCA12_RS00800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ABCA12_RS00835	COG2119	membrane
ABCA12_RS00840	COG4774	siderophore transport
ABCA12_RS00845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABCA12_RS00845	COG0426	domain, Protein
ABCA12_RS00865	COG0259	pyridoxamine-phosphate oxidase activity
ABCA12_RS00870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ABCA12_RS00895	COG1902	pentaerythritol trinitrate reductase activity
ABCA12_RS00900	COG1519	Transferase
ABCA12_RS00905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ABCA12_RS00910	COG0668	transmembrane transport
ABCA12_RS00920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABCA12_RS00925	COG1335	isochorismatase
ABCA12_RS00970	COG1309	transcriptional regulator
ABCA12_RS00975	COG3321	synthase
ABCA12_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_RS00975	COG0604	alcohol dehydrogenase
ABCA12_RS00985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ABCA12_RS00995	COG2814	Major facilitator Superfamily
ABCA12_RS01000	COG0629	single-stranded DNA binding
ABCA12_RS01005	COG1113	amino acid transport
ABCA12_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ABCA12_RS01020	COG1012	belongs to the aldehyde dehydrogenase family
ABCA12_RS01030	COG1335	isochorismatase
ABCA12_RS01040	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ABCA12_RS01070	COG3293	Transposase
ABCA12_RS01205	COG0305	Participates in initiation and elongation during chromosome replication
ABCA12_RS01235	COG0582	viral genome integration into host DNA
ABCA12_RS01285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ABCA12_RS01305	COG2329	Antibiotic biosynthesis monooxygenase
ABCA12_RS01315	COG1396	sequence-specific DNA binding
ABCA12_RS01320	COG0659	secondary active sulfate transmembrane transporter activity
ABCA12_RS01340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ABCA12_RS01370	COG0427	acetyl-CoA hydrolase
ABCA12_RS01420	COG0477	Major facilitator Superfamily
ABCA12_RS01425	COG0789	Transcriptional regulator
ABCA12_RS01430	COG3320	Male sterility
ABCA12_RS01430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ABCA12_RS01435	COG4221	oxidoreductase activity
ABCA12_RS01445	COG0488	(ABC) transporter
ABCA12_RS01525	COG0833	amino acid
ABCA12_RS01570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ABCA12_RS01575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ABCA12_RS01585	COG2226	methyltransferase
ABCA12_RS01635	COG0069	glutamate synthase activity
ABCA12_RS01635	COG0070	glutamate synthase
ABCA12_RS01635	COG0067	glutamate synthase
ABCA12_RS01640	COG0493	'glutamate synthase
ABCA12_RS01645	COG4372	Transposase
ABCA12_RS01655	COG2963	transposase activity
ABCA12_RS01660	COG1704	LemA family
ABCA12_RS01710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABCA12_RS01720	COG0194	GDP metabolic process
ABCA12_RS01725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ABCA12_RS01745	COG4969	Belongs to the N-Me-Phe pilin family
ABCA12_RS01795	COG4372	Transposase
ABCA12_RS01805	COG0228	four-way junction DNA binding
ABCA12_RS01810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ABCA12_RS01820	COG0335	large ribosomal subunit rRNA binding
ABCA12_RS01825	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ABCA12_RS01830	COG5380	lipid catabolic process
ABCA12_RS01835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ABCA12_RS01855	COG5006	permease, DMT superfamily
ABCA12_RS01860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ABCA12_RS01865	COG0277	FAD linked oxidase domain protein
ABCA12_RS01885	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ABCA12_RS01890	COG2249	NAD(P)H dehydrogenase (quinone) activity
ABCA12_RS01910	COG1289	transmembrane transporter activity
ABCA12_RS01915	COG2032	superoxide dismutase activity
ABCA12_RS01920	COG0628	permease
ABCA12_RS01925	COG1192	Involved in chromosome partitioning
ABCA12_RS01935	COG2226	methyltransferase
ABCA12_RS01950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ABCA12_RS02015	COG0471	metal ion transport
ABCA12_RS02025	COG0517	IMP dehydrogenase activity
ABCA12_RS02025	COG0617	tRNA 3'-terminal CCA addition
ABCA12_RS02025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ABCA12_RS02030	COG1983	PspC domain protein
ABCA12_RS02040	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS02055	COG0408	coproporphyrinogen oxidase activity
ABCA12_RS02075	COG0513	Belongs to the DEAD box helicase family
ABCA12_RS02080	COG3293	Transposase
ABCA12_RS02085	COG1127	ABC transporter
ABCA12_RS02090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ABCA12_RS02095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ABCA12_RS02100	COG2854	intermembrane phospholipid transfer
ABCA12_RS02115	COG0598	Magnesium transport protein CorA
ABCA12_RS02130	COG1040	competence protein
ABCA12_RS02135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ABCA12_RS02150	COG2937	Belongs to the GPAT DAPAT family
ABCA12_RS02155	COG1946	Acyl-CoA thioesterase
ABCA12_RS02160	COG1301	dicarboxylic acid transport
ABCA12_RS02185	COG0433	COG0433 Predicted ATPase
ABCA12_RS02205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ABCA12_RS02225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ABCA12_RS02250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ABCA12_RS02275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ABCA12_RS02290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ABCA12_RS02355	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS02360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ABCA12_RS02405	COG0697	spore germination
ABCA12_RS02420	COG0339	signal peptide processing
ABCA12_RS02430	COG0557	exoribonuclease II activity
ABCA12_RS02470	COG0179	Fumarylacetoacetate (FAA) hydrolase
ABCA12_RS02490	COG1295	ribonuclease BN
ABCA12_RS02525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ABCA12_RS02550	COG2813	Specifically methylates the guanine in position
ABCA12_RS02550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_RS02560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ABCA12_RS02570	COG4774	siderophore transport
ABCA12_RS02580	COG0740	serine-type endopeptidase activity
ABCA12_RS02600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ABCA12_RS02600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ABCA12_RS02615	COG0857	belongs to the CobB CobQ family
ABCA12_RS02615	COG0280	phosphate acetyltransferase
ABCA12_RS02620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ABCA12_RS02630	COG2267	carboxylic ester hydrolase activity
ABCA12_RS02645	COG0793	Belongs to the peptidase S41A family
ABCA12_RS02670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ABCA12_RS02680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ABCA12_RS02685	COG1408	metallophosphoesterase
ABCA12_RS02695	COG2199	diguanylate cyclase activity
ABCA12_RS02755	COG1607	acyl-coa hydrolase
ABCA12_RS02785	COG1666	GTP binding
ABCA12_RS02805	COG2350	Protein conserved in bacteria
ABCA12_RS02815	COG0613	PHP domain protein
ABCA12_RS02820	COG3781	membrane
ABCA12_RS02825	COG2003	Belongs to the UPF0758 family
ABCA12_RS02830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ABCA12_RS02865	COG1162	GTPase activity
ABCA12_RS02870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ABCA12_RS02895	COG1538	Outer membrane efflux protein
ABCA12_RS02900	COG0577	efflux transmembrane transporter activity
ABCA12_RS02900	COG1136	(ABC) transporter
ABCA12_RS02905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_RS02915	COG1466	dna polymerase III delta subunit
ABCA12_RS02935	COG0028	Belongs to the TPP enzyme family
ABCA12_RS02940	COG0440	acetolactate synthase activity
ABCA12_RS02945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ABCA12_RS02965	COG0640	Transcriptional regulator
ABCA12_RS02975	COG0798	PFAM Bile acid sodium symporter
ABCA12_RS02980	COG0431	NADPH-dependent FMN reductase
ABCA12_RS02995	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ABCA12_RS03005	COG0726	polysaccharide deacetylase
ABCA12_RS03010	COG0084	hydrolase, TatD family'
ABCA12_RS03025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ABCA12_RS03035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ABCA12_RS03100	COG3152	Membrane
ABCA12_RS03160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ABCA12_RS03180	COG2814	Major facilitator Superfamily
ABCA12_RS03210	COG0300	oxidoreductase activity
ABCA12_RS03215	COG0004	ammonium transporteR
ABCA12_RS03230	COG3622	Belongs to the hyi family
ABCA12_RS03235	COG2084	Dehydrogenase
ABCA12_RS03240	COG1024	Enoyl-CoA hydratase
ABCA12_RS03245	COG0784	Response regulator, receiver
ABCA12_RS03245	COG2205	protein histidine kinase activity
ABCA12_RS03245	COG5002	protein histidine kinase activity
ABCA12_RS03265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABCA12_RS03275	COG3956	TIGRFAM MazG family protein
ABCA12_RS03280	COG1555	photosystem II stabilization
ABCA12_RS03285	COG0617	tRNA 3'-terminal CCA addition
ABCA12_RS03290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ABCA12_RS03315	COG3028	Belongs to the UPF0307 family
ABCA12_RS03320	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_RS03340	COG0625	glutathione transferase activity
ABCA12_RS03345	COG1238	metal cluster binding
ABCA12_RS03380	COG0072	phenylalanine-tRNA ligase activity
ABCA12_RS03405	COG0248	Ppx GppA phosphatase
ABCA12_RS03415	COG0037	tRNA processing
ABCA12_RS03430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ABCA12_RS03430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ABCA12_RS03455	COG1764	response to oxidative stress
ABCA12_RS03465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ABCA12_RS03525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ABCA12_RS03530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ABCA12_RS03535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ABCA12_RS03585	COG0494	nUDIX hydrolase
ABCA12_RS03600	COG1968	undecaprenyl-diphosphatase activity
ABCA12_RS03625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ABCA12_RS03635	COG2132	Multicopper oxidase
ABCA12_RS03665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ABCA12_RS03670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ABCA12_RS03720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ABCA12_RS03725	COG1063	alcohol dehydrogenase
ABCA12_RS03745	COG1309	transcriptional regulator
ABCA12_RS03750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ABCA12_RS03765	COG2814	Major facilitator Superfamily
ABCA12_RS03820	COG0484	heat shock protein binding
ABCA12_RS03855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ABCA12_RS03870	COG0745	RESPONSE REGULATOR receiver
ABCA12_RS03875	COG2205	protein histidine kinase activity
ABCA12_RS03890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_RS03900	COG0649	NAD binding
ABCA12_RS03900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_RS03910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ABCA12_RS03925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_RS03940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ABCA12_RS03945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ABCA12_RS03965	COG4372	Transposase
ABCA12_RS03980	COG1278	Cold shock
ABCA12_RS03985	COG0583	DNA-binding transcription factor activity
ABCA12_RS03990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ABCA12_RS04005	COG0668	transmembrane transport
ABCA12_RS04015	COG2081	HI0933 family
ABCA12_RS04025	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ABCA12_RS04055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ABCA12_RS04065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABCA12_RS04065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABCA12_RS04090	COG0489	protein tyrosine kinase activity
ABCA12_RS04155	COG4372	Transposase
ABCA12_RS04160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ABCA12_RS04170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ABCA12_RS04190	COG0730	response to heat
ABCA12_RS04200	COG1196	nuclear chromosome segregation
ABCA12_RS04210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ABCA12_RS04230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ABCA12_RS04235	COG2226	methyltransferase
ABCA12_RS04235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_RS04235	COG0596	Alpha beta hydrolase
ABCA12_RS04250	COG4106	trans-aconitate 2-methyltransferase activity
ABCA12_RS04325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ABCA12_RS04330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ABCA12_RS04340	COG0009	L-threonylcarbamoyladenylate synthase
ABCA12_RS04345	COG3101	peptidyl-lysine hydroxylation
ABCA12_RS04350	COG1399	metal-binding, possibly nucleic acid-binding protein
ABCA12_RS04355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ABCA12_RS04375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ABCA12_RS04385	COG0351	phosphomethylpyrimidine kinase
ABCA12_RS04385	COG0352	thiamine-phosphate diphosphorylase activity
ABCA12_RS04385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ABCA12_RS04395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ABCA12_RS04430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ABCA12_RS04460	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ABCA12_RS04485	COG0564	pseudouridine synthase activity
ABCA12_RS04535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ABCA12_RS04535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ABCA12_RS04550	COG1981	membrane
ABCA12_RS04570	COG0049	tRNA binding
ABCA12_RS04580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ABCA12_RS04595	COG0456	acetyltransferase
ABCA12_RS04605	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ABCA12_RS04610	COG0500	methyltransferase
ABCA12_RS04615	COG0492	ferredoxin-NADP+ reductase activity
ABCA12_RS04620	COG1674	ftsk spoiiie
ABCA12_RS04625	COG1280	lysine exporter protein (LysE YggA)
ABCA12_RS04635	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ABCA12_RS04645	COG0850	regulation of cytokinetic process
ABCA12_RS04660	COG2885	chlorophyll binding
ABCA12_RS04665	COG0210	DNA helicase
ABCA12_RS04670	COG0756	dUTP diphosphatase activity
ABCA12_RS04675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ABCA12_RS04690	COG0121	glutamine amidotransferase
ABCA12_RS04710	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ABCA12_RS04740	COG0420	3'-5' exonuclease activity
ABCA12_RS04800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ABCA12_RS04815	COG1566	PFAM secretion protein HlyD family protein
ABCA12_RS04820	COG2814	Major facilitator Superfamily
ABCA12_RS04830	COG0789	Transcriptional regulator
ABCA12_RS04835	COG2217	Heavy metal translocating P-type atpase
ABCA12_RS04840	COG0629	single-stranded DNA binding
ABCA12_RS04880	COG0582	viral genome integration into host DNA
ABCA12_RS04915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABCA12_RS04920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ABCA12_RS04930	COG1012	belongs to the aldehyde dehydrogenase family
ABCA12_RS04945	COG0833	amino acid
ABCA12_RS04960	COG4372	Transposase
ABCA12_RS04975	COG3046	protein related to deoxyribodipyrimidine photolyase
ABCA12_RS04980	COG0725	ABC transporter, periplasmic molybdate-binding protein
ABCA12_RS04985	COG4149	molybdate abc transporter
ABCA12_RS05000	COG1230	cation diffusion facilitator family transporter
ABCA12_RS05010	COG4521	taurine ABC transporter
ABCA12_RS05015	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ABCA12_RS05025	COG2175	clavaminate synthase activity
ABCA12_RS05030	COG0589	response to stress
ABCA12_RS05050	COG0242	peptide deformylase activity
ABCA12_RS05055	COG2852	Protein conserved in bacteria
ABCA12_RS05070	COG0306	phosphate transporter
ABCA12_RS05075	COG3293	Transposase
ABCA12_RS05090	COG1115	amino acid carrier protein
ABCA12_RS05095	COG1113	amino acid transport
ABCA12_RS05105	COG0019	diaminopimelate decarboxylase activity
ABCA12_RS05110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ABCA12_RS05160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_RS05180	COG1671	Belongs to the UPF0178 family
ABCA12_RS05195	COG4591	ABC-type transport system involved in lipoprotein release permease component
ABCA12_RS05200	COG1136	(ABC) transporter
ABCA12_RS05215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ABCA12_RS05215	COG0616	signal peptide processing
ABCA12_RS05225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ABCA12_RS05235	COG0628	permease
ABCA12_RS05240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ABCA12_RS05270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ABCA12_RS05290	COG0823	Involved in the tonB-independent uptake of proteins
ABCA12_RS05310	COG0824	Thioesterase
ABCA12_RS05335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ABCA12_RS05335	COG0047	phosphoribosylformylglycinamidine synthase activity
ABCA12_RS05340	COG2814	Major facilitator Superfamily
ABCA12_RS05355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ABCA12_RS05355	COG3323	Protein of unknown function (DUF1653)
ABCA12_RS05360	COG0778	Nitroreductase
ABCA12_RS05365	COG1024	Enoyl-CoA hydratase
ABCA12_RS05370	COG1056	cytidyltransferase-related domain
ABCA12_RS05370	COG1051	belongs to the nudix hydrolase family
ABCA12_RS05385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ABCA12_RS05400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ABCA12_RS05405	COG0602	queuosine metabolic process
ABCA12_RS05420	COG0583	DNA-binding transcription factor activity
ABCA12_RS05425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ABCA12_RS05430	COG4208	sulfate ABC transporter
ABCA12_RS05435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ABCA12_RS05445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ABCA12_RS05450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ABCA12_RS05455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ABCA12_RS05470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ABCA12_RS05480	COG0481	GTPase activity
ABCA12_RS05495	COG0571	ribonuclease III activity
ABCA12_RS05500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ABCA12_RS05515	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ABCA12_RS05535	COG0436	Aminotransferase
ABCA12_RS05560	COG0556	nucleotide-excision repair
ABCA12_RS05615	COG0583	DNA-binding transcription factor activity
ABCA12_RS05620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_RS05625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_RS05630	COG1773	rubredoxin
ABCA12_RS05640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ABCA12_RS05650	COG0175	sulfate reduction
ABCA12_RS05665	COG0222	ribosome binding
ABCA12_RS05670	COG1253	flavin adenine dinucleotide binding
ABCA12_RS05700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ABCA12_RS05700	COG0517	IMP dehydrogenase activity
ABCA12_RS05705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ABCA12_RS05715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ABCA12_RS05720	COG1137	ATPase activity
ABCA12_RS05750	COG1739	Uncharacterized protein family UPF0029
ABCA12_RS05755	COG0110	maltose O-acetyltransferase activity
ABCA12_RS05775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ABCA12_RS05785	COG3293	Transposase
ABCA12_RS05815	COG1840	ABC-type Fe3 transport system, periplasmic component
ABCA12_RS05820	COG3842	ATPase activity
ABCA12_RS05830	COG1253	flavin adenine dinucleotide binding
ABCA12_RS05865	COG5002	protein histidine kinase activity
ABCA12_RS05880	COG2351	hydroxyisourate hydrolase activity
ABCA12_RS05895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ABCA12_RS05900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ABCA12_RS05940	COG4783	chaperone-mediated protein folding
ABCA12_RS05955	COG1610	YqeY-like protein
ABCA12_RS05975	COG0697	spore germination
ABCA12_RS05995	COG2815	serine threonine protein kinase
ABCA12_RS05995	COG0515	serine threonine protein kinase
ABCA12_RS06020	COG1414	Transcriptional regulator
ABCA12_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_RS06095	COG0482	sulfurtransferase activity
ABCA12_RS06110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ABCA12_RS06115	COG1686	Belongs to the peptidase S11 family
ABCA12_RS06180	COG1509	lysine 2,3-aminomutase activity
ABCA12_RS06185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ABCA12_RS06190	COG1966	Carbon starvation protein
ABCA12_RS06195	COG2879	small protein
ABCA12_RS06200	COG0714	Associated with various cellular activities
ABCA12_RS06255	COG1741	Belongs to the pirin family
ABCA12_RS06265	COG1902	pentaerythritol trinitrate reductase activity
ABCA12_RS06265	COG0446	pyridine nucleotide-disulphide oxidoreductase
ABCA12_RS06310	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS06350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ABCA12_RS06360	COG4106	trans-aconitate 2-methyltransferase activity
ABCA12_RS06365	COG0642	Histidine kinase
ABCA12_RS06370	COG0745	RESPONSE REGULATOR receiver
ABCA12_RS06395	COG2351	hydroxyisourate hydrolase activity
ABCA12_RS06415	COG3293	Transposase
ABCA12_RS06425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_RS06455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_RS06460	COG1116	anion transmembrane transporter activity
ABCA12_RS06490	COG2188	Transcriptional regulator
ABCA12_RS06520	COG0010	Belongs to the arginase family
ABCA12_RS06525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABCA12_RS06545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ABCA12_RS06565	COG1309	transcriptional regulator
ABCA12_RS06585	COG2072	flavoprotein involved in K transport
ABCA12_RS06590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ABCA12_RS06595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ABCA12_RS06600	COG1984	allophanate hydrolase subunit 2
ABCA12_RS06605	COG4770	biotin carboxylase activity
ABCA12_RS06610	COG0501	Belongs to the peptidase M48B family
ABCA12_RS06620	COG1765	OsmC-like protein
ABCA12_RS06690	COG3634	alkyl hydroperoxide reductase activity
ABCA12_RS06705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABCA12_RS06725	COG1643	Atp-dependent helicase
ABCA12_RS06740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ABCA12_RS06745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABCA12_RS06765	COG2951	lytic endotransglycosylase activity
ABCA12_RS06770	COG0772	Belongs to the SEDS family
ABCA12_RS06785	COG0842	Transport permease protein
ABCA12_RS06790	COG1131	(ABC) transporter
ABCA12_RS06825	COG3177	Filamentation induced by cAMP protein fic
ABCA12_RS06835	COG2186	Transcriptional regulator
ABCA12_RS06845	COG0277	FAD linked oxidase domain protein
ABCA12_RS06870	COG4221	oxidoreductase activity
ABCA12_RS06875	COG0583	DNA-binding transcription factor activity
ABCA12_RS06880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ABCA12_RS06900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ABCA12_RS06915	COG1979	alcohol dehydrogenase
ABCA12_RS06930	COG1309	transcriptional regulator
ABCA12_RS06950	COG3293	Transposase
ABCA12_RS06990	COG3539	Fimbrial protein
ABCA12_RS06995	COG3293	Transposase
ABCA12_RS07020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ABCA12_RS07020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ABCA12_RS07040	COG1278	Cold shock
ABCA12_RS07080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ABCA12_RS07085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ABCA12_RS07095	COG2353	YceI-like domain
ABCA12_RS07105	COG3811	Belongs to the UPF0386 family
ABCA12_RS07110	COG0590	tRNA wobble adenosine to inosine editing
ABCA12_RS07120	COG3698	Phosphodiester glycosidase
ABCA12_RS07130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ABCA12_RS07135	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ABCA12_RS07135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ABCA12_RS07135	COG0506	proline dehydrogenase activity
ABCA12_RS07145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ABCA12_RS07165	COG1132	(ABC) transporter
ABCA12_RS07180	COG0668	transmembrane transport
ABCA12_RS07185	COG3122	Protein conserved in bacteria
ABCA12_RS07235	COG2850	peptidyl-arginine hydroxylation
ABCA12_RS07240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ABCA12_RS07245	COG0824	Thioesterase
ABCA12_RS07250	COG1454	alcohol dehydrogenase
ABCA12_RS07255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ABCA12_RS07310	COG0625	glutathione transferase activity
ABCA12_RS07320	COG1113	amino acid transport
ABCA12_RS07325	COG2814	Major facilitator Superfamily
ABCA12_RS07355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_RS07355	COG1116	anion transmembrane transporter activity
ABCA12_RS07365	COG2223	nitrite transmembrane transporter activity
ABCA12_RS07370	COG2146	nitrite reductase [NAD(P)H] activity
ABCA12_RS07370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_RS07375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_RS07380	COG0243	molybdopterin cofactor binding
ABCA12_RS07415	COG0521	Mo-molybdopterin cofactor biosynthetic process
ABCA12_RS07415	COG0315	cyclic pyranopterin monophosphate synthase activity
ABCA12_RS07420	COG0303	'Molybdopterin
ABCA12_RS07495	COG2204	response regulator
ABCA12_RS07500	COG3852	Histidine kinase
ABCA12_RS07515	COG0233	cytoplasmic translational termination
ABCA12_RS07520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ABCA12_RS07525	COG0575	Belongs to the CDS family
ABCA12_RS07550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABCA12_RS07560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABCA12_RS07565	COG2207	Transcriptional regulator
ABCA12_RS07570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABCA12_RS07580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABCA12_RS07590	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS07605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ABCA12_RS07635	COG2223	nitrite transmembrane transporter activity
ABCA12_RS07650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ABCA12_RS07665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ABCA12_RS07705	COG4771	TonB-dependent receptor
ABCA12_RS07720	COG0730	response to heat
ABCA12_RS07735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ABCA12_RS07760	COG0537	adenosine 5'-monophosphoramidase activity
ABCA12_RS07790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ABCA12_RS07810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABCA12_RS07820	COG0133	tryptophan synthase activity
ABCA12_RS07835	COG3706	GGDEF domain
ABCA12_RS07865	COG3293	Transposase
ABCA12_RS07890	COG4628	conserved protein (DUF2132)
ABCA12_RS07910	COG0730	response to heat
ABCA12_RS07940	COG0583	DNA-binding transcription factor activity
ABCA12_RS07960	COG2814	Major facilitator Superfamily
ABCA12_RS07975	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_RS07980	COG1309	transcriptional regulator
ABCA12_RS07985	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS07995	COG1024	Enoyl-CoA hydratase
ABCA12_RS08000	COG4770	biotin carboxylase activity
ABCA12_RS08010	COG0583	DNA-binding transcription factor activity
ABCA12_RS08025	COG2963	transposase activity
ABCA12_RS08035	COG4372	Transposase
ABCA12_RS08045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABCA12_RS08055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_RS08060	COG0864	Transcriptional regulator
ABCA12_RS08065	COG1196	nuclear chromosome segregation
ABCA12_RS08070	COG0439	Biotin carboxylase
ABCA12_RS08085	COG1522	sequence-specific DNA binding
ABCA12_RS08110	COG1944	ATP diphosphatase activity
ABCA12_RS08120	COG0583	DNA-binding transcription factor activity
ABCA12_RS08125	COG4948	Mandelate Racemase Muconate Lactonizing
ABCA12_RS08130	COG4829	muconolactone delta-isomerase
ABCA12_RS08140	COG4638	Rieske (2fe-2S)
ABCA12_RS08145	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ABCA12_RS08150	COG0633	Ferredoxin
ABCA12_RS08150	COG0543	2 iron, 2 sulfur cluster binding
ABCA12_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_RS08160	COG3135	benzoate transporter
ABCA12_RS08165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ABCA12_RS08170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ABCA12_RS08175	COG0183	Belongs to the thiolase family
ABCA12_RS08180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ABCA12_RS08195	COG2814	Major facilitator Superfamily
ABCA12_RS08205	COG1454	alcohol dehydrogenase
ABCA12_RS08225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ABCA12_RS08235	COG1063	alcohol dehydrogenase
ABCA12_RS08250	COG1802	Transcriptional regulator
ABCA12_RS08300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ABCA12_RS08305	COG0148	phosphopyruvate hydratase activity
ABCA12_RS08350	COG1902	pentaerythritol trinitrate reductase activity
ABCA12_RS08350	COG0446	pyridine nucleotide-disulphide oxidoreductase
ABCA12_RS08365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ABCA12_RS08370	COG0488	(ABC) transporter
ABCA12_RS08380	COG0542	response to heat
ABCA12_RS08385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ABCA12_RS08390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ABCA12_RS08415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ABCA12_RS08420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ABCA12_RS08425	COG0569	domain protein
ABCA12_RS08430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ABCA12_RS08450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ABCA12_RS08475	COG1294	oxidase, subunit
ABCA12_RS08480	COG4890	Cyd operon protein YbgT
ABCA12_RS08495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ABCA12_RS08510	COG0552	protein localization to endoplasmic reticulum
ABCA12_RS08535	COG0517	IMP dehydrogenase activity
ABCA12_RS08535	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ABCA12_RS08540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ABCA12_RS08545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ABCA12_RS08555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ABCA12_RS08560	COG0583	DNA-binding transcription factor activity
ABCA12_RS08565	COG0024	Methionine aminopeptidase
ABCA12_RS08600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ABCA12_RS08605	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ABCA12_RS08645	COG4372	Transposase
ABCA12_RS08655	COG0776	regulation of translation
ABCA12_RS08720	COG0084	hydrolase, TatD family'
ABCA12_RS08740	COG1663	tetraacyldisaccharide 4'-kinase activity
ABCA12_RS08745	COG1132	(ABC) transporter
ABCA12_RS08755	COG0811	peptide transport
ABCA12_RS08760	COG1475	DNA binding
ABCA12_RS08765	COG1192	Involved in chromosome partitioning
ABCA12_RS08775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ABCA12_RS08780	COG3178	'Phosphotransferase
ABCA12_RS08790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABCA12_RS08800	COG0513	Belongs to the DEAD box helicase family
ABCA12_RS08870	COG4650	regulator
ABCA12_RS08880	COG1690	Belongs to the RtcB family
ABCA12_RS08900	COG2195	Cleaves the N-terminal amino acid of tripeptides
ABCA12_RS08940	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS08980	COG3139	Protein of unknown function (DUF1315)
ABCA12_RS08985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ABCA12_RS08990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ABCA12_RS09000	COG0494	nUDIX hydrolase
ABCA12_RS09010	COG0642	Histidine kinase
ABCA12_RS09040	COG1720	tRNA m6t6A37 methyltransferase activity
ABCA12_RS09060	COG3293	Transposase
ABCA12_RS09070	COG0583	DNA-binding transcription factor activity
ABCA12_RS09075	COG2814	Major facilitator Superfamily
ABCA12_RS09080	COG3647	Membrane
ABCA12_RS09095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ABCA12_RS09130	COG0729	surface antigen
ABCA12_RS09155	COG3293	Transposase
ABCA12_RS09170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ABCA12_RS09195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABCA12_RS09210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ABCA12_RS09225	COG2808	Putative FMN-binding domain
ABCA12_RS09240	COG4682	membrane
ABCA12_RS09255	COG0826	peptidase U32
ABCA12_RS09260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ABCA12_RS09305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABCA12_RS09335	COG4372	Transposase
ABCA12_RS09380	COG1560	Kdo2-lipid A biosynthetic process
ABCA12_RS09400	COG0204	Acyl-transferase
ABCA12_RS09435	COG1464	Belongs to the NlpA lipoprotein family
ABCA12_RS09440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ABCA12_RS09445	COG2011	ABC-type metal ion transport system permease component
ABCA12_RS09450	COG0012	GTP binding
ABCA12_RS09515	COG0386	Belongs to the glutathione peroxidase family
ABCA12_RS09525	COG0436	Aminotransferase
ABCA12_RS09560	COG2267	carboxylic ester hydrolase activity
ABCA12_RS09565	COG3634	alkyl hydroperoxide reductase activity
ABCA12_RS09615	COG1286	toxin biosynthetic process
ABCA12_RS09645	COG0778	Nitroreductase
ABCA12_RS09670	COG0424	maF-like protein
ABCA12_RS09700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ABCA12_RS09705	COG2030	dehydratase
ABCA12_RS09730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ABCA12_RS09735	COG0702	epimerase
ABCA12_RS09740	COG0268	Binds directly to 16S ribosomal RNA
ABCA12_RS09760	COG1011	Hydrolase
ABCA12_RS09765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ABCA12_RS09775	COG2137	regulation of response to DNA damage stimulus
ABCA12_RS09790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABCA12_RS09820	COG0822	iron-sulfur transferase activity
ABCA12_RS09825	COG0316	Belongs to the HesB IscA family
ABCA12_RS09855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ABCA12_RS09870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ABCA12_RS09880	COG3135	benzoate transporter
ABCA12_RS09885	COG0475	glutathione-regulated potassium exporter activity
ABCA12_RS09885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ABCA12_RS09890	COG1714	RDD family
ABCA12_RS09900	COG1760	l-serine dehydratase
ABCA12_RS09905	COG0308	aminopeptidase N
ABCA12_RS09965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ABCA12_RS09975	COG0531	amino acid
ABCA12_RS09985	COG0519	Catalyzes the synthesis of GMP from XMP
ABCA12_RS09985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ABCA12_RS10015	COG0697	spore germination
ABCA12_RS10020	COG1923	regulation of RNA biosynthetic process
ABCA12_RS10030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ABCA12_RS10035	COG0802	atpase or kinase
ABCA12_RS10045	COG0564	pseudouridine synthase activity
ABCA12_RS10070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ABCA12_RS10095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ABCA12_RS10100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ABCA12_RS10105	COG1845	cytochrome c oxidase, subunit III
ABCA12_RS10110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ABCA12_RS10145	COG0305	Participates in initiation and elongation during chromosome replication
ABCA12_RS10150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ABCA12_RS10160	COG1305	Transglutaminase-like
ABCA12_RS10170	COG2308	Evidence 4 Homologs of previously reported genes of
ABCA12_RS10180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ABCA12_RS10195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ABCA12_RS10205	COG0527	aspartate kinase activity
ABCA12_RS10215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ABCA12_RS10230	COG3038	cytochrome b561
ABCA12_RS10235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ABCA12_RS10240	COG2252	PERMEase
ABCA12_RS10290	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ABCA12_RS10295	COG0138	bifunctional purine biosynthesis protein purh
ABCA12_RS10300	COG0151	Belongs to the GarS family
ABCA12_RS10310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ABCA12_RS10315	COG2011	ABC-type metal ion transport system permease component
ABCA12_RS10340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ABCA12_RS10350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ABCA12_RS10360	COG0280	phosphate acetyltransferase
ABCA12_RS10360	COG0281	malic enzyme
ABCA12_RS10375	COG0052	Belongs to the universal ribosomal protein uS2 family
ABCA12_RS10380	COG0024	Methionine aminopeptidase
ABCA12_RS10390	COG2223	nitrite transmembrane transporter activity
ABCA12_RS10400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ABCA12_RS10405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ABCA12_RS10410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ABCA12_RS10450	COG3161	chorismate lyase activity
ABCA12_RS10455	COG0174	glutamine synthetase
ABCA12_RS10460	COG0512	Glutamine amidotransferase of anthranilate synthase
ABCA12_RS10465	COG1823	symporter activity
ABCA12_RS10470	COG0633	Ferredoxin
ABCA12_RS10470	COG3217	Mosc domain protein beta barrel domain protein
ABCA12_RS10485	COG3293	Transposase
ABCA12_RS10500	COG0302	gtp cyclohydrolase
ABCA12_RS10530	COG3739	integral membrane protein
ABCA12_RS10555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ABCA12_RS10575	COG4172	Belongs to the ABC transporter superfamily
ABCA12_RS10580	COG4239	(ABC) transporter, permease
ABCA12_RS10585	COG4174	ABC transporter (Permease)
ABCA12_RS10590	COG4166	transmembrane transport
ABCA12_RS10595	COG0741	lytic transglycosylase activity
ABCA12_RS10595	COG1388	LysM domain
ABCA12_RS10600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ABCA12_RS10660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_RS10665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_RS10670	COG0006	proline dipeptidase activity
ABCA12_RS10705	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ABCA12_RS10755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ABCA12_RS10770	COG3384	dioxygenase
ABCA12_RS10780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ABCA12_RS10785	COG2878	Part of a membrane complex involved in electron transport
ABCA12_RS10790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ABCA12_RS10815	COG0768	penicillin binding
ABCA12_RS10820	COG0742	ribosomal rna small subunit methyltransferase
ABCA12_RS10845	COG0616	signal peptide processing
ABCA12_RS10855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ABCA12_RS10865	COG0573	inorganic phosphate transmembrane transporter activity
ABCA12_RS10880	COG0076	glutamate decarboxylase activity
ABCA12_RS10885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ABCA12_RS10895	COG1309	transcriptional regulator
ABCA12_RS10915	COG1309	transcriptional regulator
ABCA12_RS10930	COG0783	Belongs to the Dps family
ABCA12_RS10945	COG0564	pseudouridine synthase activity
ABCA12_RS10955	COG0352	thiamine-phosphate diphosphorylase activity
ABCA12_RS10980	COG1203	CRISPR-associated helicase, Cas3
ABCA12_RS11020	COG0612	Peptidase, M16
ABCA12_RS11025	COG0384	phenazine biosynthesis protein PhzF
ABCA12_RS11035	COG1187	pseudouridine synthase activity
ABCA12_RS11055	COG1686	Belongs to the peptidase S11 family
ABCA12_RS11060	COG1252	NADH dehydrogenase
ABCA12_RS11070	COG0415	Belongs to the DNA photolyase family
ABCA12_RS11090	COG1294	oxidase, subunit
ABCA12_RS11095	COG2070	2-Nitropropane dioxygenase
ABCA12_RS11110	COG0705	Rhomboid family
ABCA12_RS11110	COG0457	Tetratricopeptide repeat
ABCA12_RS11120	COG4181	ATPase activity
ABCA12_RS11130	COG0288	reversible hydration of carbon dioxide
ABCA12_RS11160	COG3293	Transposase
ABCA12_RS11175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ABCA12_RS11210	COG1597	lipid kinase activity
ABCA12_RS11215	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ABCA12_RS11230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ABCA12_RS11240	COG2388	GCN5-related N-acetyl-transferase
ABCA12_RS11280	COG1215	transferase activity, transferring glycosyl groups
ABCA12_RS11285	COG1649	PFAM Uncharacterised BCR, COG1649
ABCA12_RS11285	COG0726	polysaccharide deacetylase
ABCA12_RS11300	COG4681	YaeQ
ABCA12_RS11305	COG0523	cobalamin synthesis protein
ABCA12_RS11315	COG1607	acyl-coa hydrolase
ABCA12_RS11340	COG0583	DNA-binding transcription factor activity
ABCA12_RS11350	COG1301	dicarboxylic acid transport
ABCA12_RS11355	COG0582	viral genome integration into host DNA
ABCA12_RS11380	COG2814	Major facilitator Superfamily
ABCA12_RS11460	COG3311	Transcriptional regulator
ABCA12_RS11480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ABCA12_RS11505	COG2132	Multicopper oxidase
ABCA12_RS11520	COG2205	protein histidine kinase activity
ABCA12_RS11525	COG2217	Heavy metal translocating P-type atpase
ABCA12_RS11545	COG2184	nucleotidyltransferase activity
ABCA12_RS11605	COG0789	Transcriptional regulator
ABCA12_RS11650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ABCA12_RS11655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ABCA12_RS11670	COG0741	lytic transglycosylase activity
ABCA12_RS11675	COG0501	Belongs to the peptidase M48B family
ABCA12_RS11685	COG2239	Acts as a magnesium transporter
ABCA12_RS11695	COG2194	sulfuric ester hydrolase activity
ABCA12_RS11700	COG0584	glycerophosphoryl diester phosphodiesterase
ABCA12_RS11705	COG3201	nicotinamide mononucleotide transporter
ABCA12_RS11725	COG2304	oxidoreductase activity
ABCA12_RS11730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ABCA12_RS11735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ABCA12_RS11760	COG0505	Belongs to the CarA family
ABCA12_RS11785	COG0589	response to stress
ABCA12_RS11805	COG4372	Transposase
ABCA12_RS11825	COG2321	neutral zinc metallopeptidase
ABCA12_RS11830	COG2354	Protein conserved in bacteria
ABCA12_RS11840	COG1585	Membrane protein implicated in regulation of membrane protease activity
ABCA12_RS11890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ABCA12_RS11905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ABCA12_RS11910	COG1053	succinate dehydrogenase
ABCA12_RS11915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ABCA12_RS11920	COG2009	succinate dehydrogenase
ABCA12_RS11945	COG1054	Belongs to the UPF0176 family
ABCA12_RS11950	COG0586	Pfam SNARE associated Golgi protein
ABCA12_RS11955	COG0500	methyltransferase
ABCA12_RS12000	COG0321	lipoyl(octanoyl) transferase activity
ABCA12_RS12015	COG0531	amino acid
ABCA12_RS12030	COG1733	regulation of RNA biosynthetic process
ABCA12_RS12035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ABCA12_RS12040	COG1648	precorrin-2 dehydrogenase activity
ABCA12_RS12040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ABCA12_RS12055	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ABCA12_RS12085	COG0671	phosphoesterase, PA-phosphatase related
ABCA12_RS12090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ABCA12_RS12100	COG1538	Outer membrane efflux protein
ABCA12_RS12105	COG0393	Putative heavy-metal-binding
ABCA12_RS12110	COG0393	Putative heavy-metal-binding
ABCA12_RS12120	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_RS12130	COG0525	valine-tRNA ligase activity
ABCA12_RS12140	COG0004	ammonium transporteR
ABCA12_RS12155	COG0642	Histidine kinase
ABCA12_RS12160	COG0745	RESPONSE REGULATOR receiver
ABCA12_RS12165	COG2194	sulfuric ester hydrolase activity
ABCA12_RS12185	COG1752	Esterase of the alpha-beta hydrolase superfamily
ABCA12_RS12200	COG2814	Major facilitator Superfamily
ABCA12_RS12205	COG0142	geranyltranstransferase activity
ABCA12_RS12215	COG1113	amino acid transport
ABCA12_RS12225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ABCA12_RS12230	COG0210	DNA helicase
ABCA12_RS12240	COG0174	glutamine synthetase
ABCA12_RS12245	COG0671	phosphoesterase, PA-phosphatase related
ABCA12_RS12255	COG2851	Citrate transporter
ABCA12_RS12280	COG0745	RESPONSE REGULATOR receiver
ABCA12_RS12290	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ABCA12_RS12295	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ABCA12_RS12300	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ABCA12_RS12315	COG0560	Phosphoserine phosphatase
ABCA12_RS12325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ABCA12_RS12330	COG1530	ribonuclease E activity
ABCA12_RS12335	COG0424	maF-like protein
ABCA12_RS12345	COG1792	Involved in formation and maintenance of cell shape
ABCA12_RS12350	COG1077	Cell shape determining protein MreB Mrl
ABCA12_RS12355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ABCA12_RS12365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ABCA12_RS12385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ABCA12_RS12425	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ABCA12_RS12430	COG1752	Esterase of the alpha-beta hydrolase superfamily
ABCA12_RS12435	COG1115	amino acid carrier protein
ABCA12_RS12455	COG2814	Major facilitator Superfamily
ABCA12_RS12460	COG1289	transmembrane transporter activity
ABCA12_RS12515	COG1376	ErfK ybiS ycfS ynhG family protein
ABCA12_RS12520	COG2832	Protein of unknown function (DUF454)
ABCA12_RS12530	COG5510	response to toxic substance
ABCA12_RS12545	COG0643	Histidine kinase
ABCA12_RS12545	COG0643	Histidine kinase
ABCA12_RS12545	COG2198	Histidine kinase
ABCA12_RS12545	COG2198	Histidine kinase
ABCA12_RS12550	COG0840	transmembrane signaling receptor activity
ABCA12_RS12580	COG3422	double-strand break repair
ABCA12_RS12585	COG2824	Alkylphosphonate utilization operon protein PhnA
ABCA12_RS12590	COG3189	MarR family transcriptional regulator
ABCA12_RS12600	COG0354	folic acid binding
ABCA12_RS12610	COG4772	TonB-dependent receptor
ABCA12_RS12620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ABCA12_RS12635	COG1217	gtp-binding protein TYPA
ABCA12_RS12640	COG2233	PERMEase
ABCA12_RS12650	COG0833	amino acid
ABCA12_RS12655	COG1690	Belongs to the RtcB family
ABCA12_RS12675	COG0183	Belongs to the thiolase family
ABCA12_RS12695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ABCA12_RS12710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ABCA12_RS12715	COG2207	Transcriptional regulator
ABCA12_RS12730	COG0183	Belongs to the thiolase family
ABCA12_RS12765	COG1272	protein, Hemolysin III
ABCA12_RS12770	COG0477	Major facilitator Superfamily
ABCA12_RS12790	COG0450	alkyl hydroperoxide reductase
ABCA12_RS12815	COG0285	dihydrofolate synthase activity
ABCA12_RS12870	COG4206	TonB-dependent receptor
ABCA12_RS12875	COG2096	Adenosyltransferase
ABCA12_RS12895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ABCA12_RS12910	COG0745	RESPONSE REGULATOR receiver
ABCA12_RS12915	COG2205	protein histidine kinase activity
ABCA12_RS12925	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS12930	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS13000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ABCA12_RS13040	COG0438	transferase activity, transferring glycosyl groups
ABCA12_RS13060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ABCA12_RS13065	COG2205	protein histidine kinase activity
ABCA12_RS13065	COG0784	Response regulator, receiver
ABCA12_RS13075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ABCA12_RS13095	COG1862	Preprotein translocase
ABCA12_RS13175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ABCA12_RS13180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ABCA12_RS13185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ABCA12_RS13200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ABCA12_RS13205	COG0625	glutathione transferase activity
ABCA12_RS13210	COG2969	positive regulation of protein catabolic process
ABCA12_RS13250	COG3293	Transposase
ABCA12_RS13280	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS13285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ABCA12_RS13300	COG1309	transcriptional regulator
ABCA12_RS13360	COG1183	phosphatidylcholine synthase activity
ABCA12_RS13365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ABCA12_RS13395	COG1196	nuclear chromosome segregation
ABCA12_RS13395	COG0741	lytic transglycosylase activity
ABCA12_RS13395	COG0739	heme binding
ABCA12_RS13405	COG1702	phosphate starvation-inducible protein PhoH
ABCA12_RS13425	COG4773	Receptor
ABCA12_RS13490	COG0788	formyltetrahydrofolate deformylase activity
ABCA12_RS13515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ABCA12_RS13515	COG4651	solute:proton antiporter activity
ABCA12_RS13535	COG0724	RNA recognition motif
ABCA12_RS13540	COG0210	DNA helicase
ABCA12_RS13575	COG2900	Belongs to the SlyX family
ABCA12_RS13580	COG0488	(ABC) transporter
ABCA12_RS13590	COG1560	Kdo2-lipid A biosynthetic process
ABCA12_RS13645	COG0473	3-isopropylmalate dehydrogenase activity
ABCA12_RS13670	COG0583	DNA-binding transcription factor activity
ABCA12_RS13695	COG0494	nUDIX hydrolase
ABCA12_RS13715	COG3011	Protein conserved in bacteria
ABCA12_RS13730	COG0583	DNA-binding transcription factor activity
ABCA12_RS13755	COG1530	ribonuclease E activity
ABCA12_RS13760	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_RS13780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ABCA12_RS13795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ABCA12_RS13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ABCA12_RS13855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ABCA12_RS13880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ABCA12_RS13890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ABCA12_RS13890	COG0644	oxidoreductase
ABCA12_RS13900	COG1595	DNA-templated transcription, initiation
ABCA12_RS13910	COG3220	belongs to the UPF0276 family
ABCA12_RS13925	COG1279	arginine transmembrane transporter activity
ABCA12_RS13930	COG0425	Belongs to the sulfur carrier protein TusA family
ABCA12_RS13935	COG4535	Mg2 and Co2 transporter CorC
ABCA12_RS13960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ABCA12_RS13970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ABCA12_RS13985	COG0789	Transcriptional regulator
ABCA12_RS13990	COG0598	Magnesium transport protein CorA
ABCA12_RS13995	COG1185	polyribonucleotide nucleotidyltransferase activity
ABCA12_RS14000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ABCA12_RS14005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ABCA12_RS14010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ABCA12_RS14020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ABCA12_RS14040	COG2226	methyltransferase
ABCA12_RS14050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ABCA12_RS14065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ABCA12_RS14080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ABCA12_RS14095	COG2111	Na H antiporter
ABCA12_RS14095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ABCA12_RS14100	COG1006	Multisubunit Na H antiporter MnhC subunit
ABCA12_RS14105	COG0651	ATP synthesis coupled electron transport
ABCA12_RS14110	COG1863	multisubunit Na H antiporter MnhE subunit
ABCA12_RS14115	COG2212	antiporter activity
ABCA12_RS14120	COG1320	monovalent cation:proton antiporter activity
ABCA12_RS14125	COG4372	Transposase
ABCA12_RS14140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ABCA12_RS14150	COG0195	Participates in both transcription termination and antitermination
ABCA12_RS14200	COG0237	dephospho-CoA kinase activity
ABCA12_RS14210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ABCA12_RS14220	COG0497	DNA recombination
ABCA12_RS14230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ABCA12_RS14255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ABCA12_RS14285	COG3706	GGDEF domain
ABCA12_RS14320	COG1132	(ABC) transporter
ABCA12_RS14335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ABCA12_RS14355	COG0326	Molecular chaperone. Has ATPase activity
ABCA12_RS14370	COG2056	Na+-H+ antiporter family
ABCA12_RS14415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ABCA12_RS14435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ABCA12_RS14465	COG0546	phosphoglycolate phosphatase activity
ABCA12_RS14470	COG1716	ATPase activity
ABCA12_RS14515	COG0181	hydroxymethylbilane synthase activity
ABCA12_RS14525	COG3275	phosphorelay sensor kinase activity
ABCA12_RS14565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ABCA12_RS14570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ABCA12_RS14575	COG0772	Belongs to the SEDS family
ABCA12_RS14600	COG4974	Belongs to the 'phage' integrase family
ABCA12_RS14605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ABCA12_RS14615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ABCA12_RS14635	COG2197	response regulator
ABCA12_RS14650	COG0793	Belongs to the peptidase S41A family
ABCA12_RS14655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ABCA12_RS14660	COG0795	lipopolysaccharide-transporting ATPase activity
ABCA12_RS14665	COG0795	lipopolysaccharide-transporting ATPase activity
ABCA12_RS14700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ABCA12_RS14700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ABCA12_RS14710	COG0004	ammonium transporteR
ABCA12_RS14715	COG0347	Belongs to the P(II) protein family
ABCA12_RS14745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ABCA12_RS14760	COG0318	PFAM AMP-dependent synthetase and ligase
ABCA12_RS14770	COG2860	membrane
ABCA12_RS14780	COG1253	flavin adenine dinucleotide binding
ABCA12_RS14795	COG2814	Major facilitator Superfamily
ABCA12_RS14810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ABCA12_RS14815	COG0745	RESPONSE REGULATOR receiver
ABCA12_RS14820	COG2205	protein histidine kinase activity
ABCA12_RS14825	COG4452	Inner membrane protein CreD
ABCA12_RS14870	COG0655	NAD(P)H dehydrogenase (quinone) activity
ABCA12_RS14890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ABCA12_RS14895	COG1283	sodium-dependent phosphate transmembrane transporter activity
ABCA12_RS14925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ABCA12_RS14945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ABCA12_RS14950	COG3162	membrane
ABCA12_RS14955	COG0784	Response regulator, receiver
ABCA12_RS14955	COG2205	protein histidine kinase activity
ABCA12_RS14980	COG1652	LysM domain
ABCA12_RS14985	COG0758	DNA mediated transformation
ABCA12_RS15000	COG1309	transcriptional regulator
ABCA12_RS15015	COG0386	Belongs to the glutathione peroxidase family
ABCA12_RS15030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ABCA12_RS15070	COG0803	Belongs to the bacterial solute-binding protein 9 family
ABCA12_RS15080	COG1121	(ABC) transporter
ABCA12_RS15085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ABCA12_RS15095	COG2837	iron assimilation
ABCA12_RS15105	COG0281	malic enzyme
ABCA12_RS15140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ABCA12_RS15140	COG0519	Catalyzes the synthesis of GMP from XMP
ABCA12_RS15145	COG4399	Belongs to the UPF0754 family
ABCA12_RS15165	COG0586	Pfam SNARE associated Golgi protein
ABCA12_RS15180	COG1192	Involved in chromosome partitioning
ABCA12_RS15190	COG0271	Belongs to the BolA IbaG family
ABCA12_RS15225	COG3756	Protein conserved in bacteria
ABCA12_RS15240	COG0494	nUDIX hydrolase
ABCA12_RS15285	COG3550	peptidyl-serine autophosphorylation
ABCA12_RS15290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ABCA12_RS15345	COG4372	Transposase
ABCA12_RS15350	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ABCA12_RS15390	COG0477	Major facilitator Superfamily
ABCA12_RS15395	COG1024	Enoyl-CoA hydratase
ABCA12_RS15400	COG1024	Enoyl-CoA hydratase
ABCA12_RS15405	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS15410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ABCA12_RS15430	COG1113	amino acid transport
ABCA12_RS15435	COG0251	oxidation-reduction process
ABCA12_RS15470	COG0564	pseudouridine synthase activity
ABCA12_RS15515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ABCA12_RS15530	COG1802	Transcriptional regulator
ABCA12_RS15535	COG1448	Aminotransferase
ABCA12_RS15540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ABCA12_RS15545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ABCA12_RS15560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ABCA12_RS15575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ABCA12_RS15595	COG0438	transferase activity, transferring glycosyl groups
ABCA12_RS15615	COG0438	transferase activity, transferring glycosyl groups
ABCA12_RS15635	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ABCA12_RS15640	COG1596	polysaccharide export
ABCA12_RS15660	COG0545	Peptidyl-prolyl cis-trans isomerase
ABCA12_RS15670	COG3023	N-Acetylmuramoyl-L-alanine amidase
ABCA12_RS15685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ABCA12_RS15720	COG0546	phosphoglycolate phosphatase activity
ABCA12_RS15725	COG1028	Short-chain dehydrogenase reductase Sdr
ABCA12_RS15735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ABCA12_RS15735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ABCA12_RS15740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ABCA12_RS15745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ABCA12_RS15750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ABCA12_RS15755	COG1116	anion transmembrane transporter activity
ABCA12_RS15760	COG1309	transcriptional regulator
ABCA12_RS15775	COG0196	riboflavin kinase activity
ABCA12_RS15780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ABCA12_RS15790	COG1047	Peptidyl-prolyl cis-trans
ABCA12_RS15800	COG0653	protein targeting
ABCA12_RS15840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ABCA12_RS15845	COG0657	acetylesterase activity
ABCA12_RS15870	COG0443	Heat shock 70 kDa protein
ABCA12_RS15875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ABCA12_RS15910	COG2951	lytic endotransglycosylase activity
ABCA12_RS15915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ABCA12_RS15935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ABCA12_RS15955	COG1960	acyl-CoA dehydrogenase activity
ABCA12_RS15960	COG0583	DNA-binding transcription factor activity
ABCA12_RS15970	COG0861	Integral membrane protein TerC family
ABCA12_RS15980	COG0754	glutathionylspermidine amidase activity
ABCA12_RS15990	COG0402	S-adenosylhomocysteine deaminase activity
ABCA12_RS16020	COG0706	membrane insertase activity