locus-tag	class	description
CS557_RS00010	COG0592	DNA-directed DNA polymerase activity
CS557_RS00020	COG0187	DNA topoisomerase II activity
CS557_RS00030	COG0586	Pfam SNARE associated Golgi protein
CS557_RS00035	COG0488	(ABC) transporter
CS557_RS00070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CS557_RS00075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CS557_RS00120	COG1012	belongs to the aldehyde dehydrogenase family
CS557_RS00125	COG0733	neurotransmitter:sodium symporter activity
CS557_RS00160	COG0583	DNA-binding transcription factor activity
CS557_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS00170	COG2233	PERMEase
CS557_RS00180	COG1309	transcriptional regulator
CS557_RS00185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS557_RS00215	COG2814	Major facilitator Superfamily
CS557_RS00220	COG0656	L-ascorbic acid biosynthetic process
CS557_RS00225	COG0583	DNA-binding transcription factor activity
CS557_RS00235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS557_RS00240	COG1064	alcohol dehydrogenase
CS557_RS00245	COG2818	Glycosylase
CS557_RS00255	COG0739	heme binding
CS557_RS00270	COG5487	UPF0391 membrane protein
CS557_RS00275	COG2983	Belongs to the UPF0260 family
CS557_RS00280	COG2133	pyrroloquinoline quinone binding
CS557_RS00290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CS557_RS00295	COG0697	spore germination
CS557_RS00305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CS557_RS00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS557_RS00320	COG1335	isochorismatase
CS557_RS00335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CS557_RS00345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CS557_RS00350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CS557_RS00355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS557_RS00375	COG3830	Belongs to the UPF0237 family
CS557_RS00375	COG0560	Phosphoserine phosphatase
CS557_RS00425	COG0583	DNA-binding transcription factor activity
CS557_RS00460	COG0534	Mate efflux family protein
CS557_RS00465	COG0436	Aminotransferase
CS557_RS00475	COG2733	membrane
CS557_RS00490	COG2918	glutathione biosynthetic process
CS557_RS00540	COG3150	esterase
CS557_RS00550	COG0534	Mate efflux family protein
CS557_RS00585	COG1247	-acetyltransferase
CS557_RS00635	COG1393	Belongs to the ArsC family
CS557_RS00640	COG0708	Exodeoxyribonuclease III
CS557_RS00675	COG0386	Belongs to the glutathione peroxidase family
CS557_RS00680	COG0189	ligase activity
CS557_RS00700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CS557_RS00710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS557_RS00750	COG2119	membrane
CS557_RS00755	COG4774	siderophore transport
CS557_RS00760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS557_RS00760	COG0426	domain, Protein
CS557_RS00780	COG0259	pyridoxamine-phosphate oxidase activity
CS557_RS00785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CS557_RS00810	COG1902	pentaerythritol trinitrate reductase activity
CS557_RS00815	COG1519	Transferase
CS557_RS00820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CS557_RS00825	COG0668	transmembrane transport
CS557_RS00835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS557_RS00840	COG1335	isochorismatase
CS557_RS00880	COG1309	transcriptional regulator
CS557_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS00885	COG3321	synthase
CS557_RS00885	COG0604	alcohol dehydrogenase
CS557_RS00895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CS557_RS00905	COG2814	Major facilitator Superfamily
CS557_RS00910	COG0629	single-stranded DNA binding
CS557_RS00915	COG1113	amino acid transport
CS557_RS00925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS557_RS00930	COG1012	belongs to the aldehyde dehydrogenase family
CS557_RS00940	COG1335	isochorismatase
CS557_RS00950	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CS557_RS01090	COG2815	serine threonine protein kinase
CS557_RS01090	COG0515	serine threonine protein kinase
CS557_RS01095	COG0582	viral genome integration into host DNA
CS557_RS01170	COG0305	Participates in initiation and elongation during chromosome replication
CS557_RS01205	COG0582	viral genome integration into host DNA
CS557_RS01250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS557_RS01270	COG2329	Antibiotic biosynthesis monooxygenase
CS557_RS01280	COG1396	sequence-specific DNA binding
CS557_RS01285	COG0659	secondary active sulfate transmembrane transporter activity
CS557_RS01305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CS557_RS01335	COG0427	acetyl-CoA hydrolase
CS557_RS01375	COG0477	Major facilitator Superfamily
CS557_RS01380	COG0789	Transcriptional regulator
CS557_RS01385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS557_RS01385	COG3320	Male sterility
CS557_RS01390	COG4221	oxidoreductase activity
CS557_RS01400	COG0488	(ABC) transporter
CS557_RS01475	COG0833	amino acid
CS557_RS01500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CS557_RS01520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CS557_RS01525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS557_RS01535	COG2226	methyltransferase
CS557_RS01585	COG0067	glutamate synthase
CS557_RS01585	COG0069	glutamate synthase activity
CS557_RS01585	COG0070	glutamate synthase
CS557_RS01590	COG0493	'glutamate synthase
CS557_RS01600	COG1704	LemA family
CS557_RS01605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CS557_RS01625	COG3307	-O-antigen
CS557_RS01635	COG3307	-O-antigen
CS557_RS01655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS557_RS01665	COG0194	GDP metabolic process
CS557_RS01670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CS557_RS01675	COG4969	Belongs to the N-Me-Phe pilin family
CS557_RS01710	COG0228	four-way junction DNA binding
CS557_RS01715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CS557_RS01725	COG0335	large ribosomal subunit rRNA binding
CS557_RS01730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CS557_RS01735	COG5380	lipid catabolic process
CS557_RS01740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CS557_RS01760	COG5006	permease, DMT superfamily
CS557_RS01765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS557_RS01770	COG0277	FAD linked oxidase domain protein
CS557_RS01790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CS557_RS01795	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS557_RS01815	COG1289	transmembrane transporter activity
CS557_RS01820	COG2032	superoxide dismutase activity
CS557_RS01825	COG0628	permease
CS557_RS01830	COG1192	Involved in chromosome partitioning
CS557_RS01840	COG2226	methyltransferase
CS557_RS01855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS557_RS01875	COG1404	Belongs to the peptidase S8 family
CS557_RS01885	COG2072	flavoprotein involved in K transport
CS557_RS01920	COG0471	metal ion transport
CS557_RS01930	COG0517	IMP dehydrogenase activity
CS557_RS01935	COG1983	PspC domain protein
CS557_RS01945	COG1960	acyl-CoA dehydrogenase activity
CS557_RS01960	COG0408	coproporphyrinogen oxidase activity
CS557_RS01980	COG0513	Belongs to the DEAD box helicase family
CS557_RS01990	COG1127	ABC transporter
CS557_RS01995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CS557_RS02000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CS557_RS02005	COG2854	intermembrane phospholipid transfer
CS557_RS02020	COG0598	Magnesium transport protein CorA
CS557_RS02035	COG1040	competence protein
CS557_RS02040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CS557_RS02055	COG2937	Belongs to the GPAT DAPAT family
CS557_RS02060	COG1946	Acyl-CoA thioesterase
CS557_RS02065	COG1301	dicarboxylic acid transport
CS557_RS02080	COG1959	2 iron, 2 sulfur cluster binding
CS557_RS02090	COG0433	COG0433 Predicted ATPase
CS557_RS02095	COG0626	cystathionine gamma-synthase activity
CS557_RS02110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CS557_RS02130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CS557_RS02155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CS557_RS02180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CS557_RS02195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CS557_RS02260	COG1960	acyl-CoA dehydrogenase activity
CS557_RS02265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CS557_RS02305	COG0697	spore germination
CS557_RS02320	COG0339	signal peptide processing
CS557_RS02365	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS557_RS02385	COG1295	ribonuclease BN
CS557_RS02415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS557_RS02440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CS557_RS02440	COG2813	Specifically methylates the guanine in position
CS557_RS02450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS557_RS02465	COG4774	siderophore transport
CS557_RS02475	COG0740	serine-type endopeptidase activity
CS557_RS02495	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CS557_RS02495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CS557_RS02510	COG0280	phosphate acetyltransferase
CS557_RS02510	COG0857	belongs to the CobB CobQ family
CS557_RS02515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CS557_RS02525	COG2267	carboxylic ester hydrolase activity
CS557_RS02540	COG0793	Belongs to the peptidase S41A family
CS557_RS02565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CS557_RS02575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS557_RS02580	COG1408	metallophosphoesterase
CS557_RS02590	COG2199	diguanylate cyclase activity
CS557_RS02645	COG1607	acyl-coa hydrolase
CS557_RS02650	COG1956	GAF domain-containing protein
CS557_RS02665	COG1666	GTP binding
CS557_RS02685	COG2350	Protein conserved in bacteria
CS557_RS02695	COG0613	PHP domain protein
CS557_RS02700	COG3781	membrane
CS557_RS02705	COG2003	Belongs to the UPF0758 family
CS557_RS02710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CS557_RS02745	COG1162	GTPase activity
CS557_RS02750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CS557_RS02770	COG1538	Outer membrane efflux protein
CS557_RS02775	COG1136	(ABC) transporter
CS557_RS02775	COG0577	efflux transmembrane transporter activity
CS557_RS02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS557_RS02790	COG1466	dna polymerase III delta subunit
CS557_RS02810	COG0028	Belongs to the TPP enzyme family
CS557_RS02815	COG0440	acetolactate synthase activity
CS557_RS02830	COG3243	poly(R)-hydroxyalkanoic acid synthase
CS557_RS02840	COG0640	Transcriptional regulator
CS557_RS02850	COG0798	PFAM Bile acid sodium symporter
CS557_RS02855	COG0431	NADPH-dependent FMN reductase
CS557_RS02870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CS557_RS02880	COG0726	polysaccharide deacetylase
CS557_RS02885	COG0084	hydrolase, TatD family'
CS557_RS02905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CS557_RS02915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CS557_RS02920	COG2814	Major facilitator Superfamily
CS557_RS02930	COG0789	Transcriptional regulator
CS557_RS02950	COG0300	oxidoreductase activity
CS557_RS02955	COG0004	ammonium transporteR
CS557_RS02970	COG3622	Belongs to the hyi family
CS557_RS02975	COG2084	Dehydrogenase
CS557_RS02980	COG1024	Enoyl-CoA hydratase
CS557_RS02985	COG0784	Response regulator, receiver
CS557_RS02985	COG2205	protein histidine kinase activity
CS557_RS02985	COG5002	protein histidine kinase activity
CS557_RS03005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS557_RS03015	COG3956	TIGRFAM MazG family protein
CS557_RS03020	COG1555	photosystem II stabilization
CS557_RS03025	COG0617	tRNA 3'-terminal CCA addition
CS557_RS03030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CS557_RS03055	COG3028	Belongs to the UPF0307 family
CS557_RS03060	COG0318	PFAM AMP-dependent synthetase and ligase
CS557_RS03085	COG0625	glutathione transferase activity
CS557_RS03095	COG1238	metal cluster binding
CS557_RS03130	COG0072	phenylalanine-tRNA ligase activity
CS557_RS03155	COG0248	Ppx GppA phosphatase
CS557_RS03165	COG0037	tRNA processing
CS557_RS03180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS557_RS03180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS557_RS03205	COG1764	response to oxidative stress
CS557_RS03215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS557_RS03275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CS557_RS03280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CS557_RS03285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CS557_RS03350	COG1968	undecaprenyl-diphosphatase activity
CS557_RS03375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CS557_RS03385	COG2132	Multicopper oxidase
CS557_RS03415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CS557_RS03420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CS557_RS03470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CS557_RS03475	COG1063	alcohol dehydrogenase
CS557_RS03495	COG1309	transcriptional regulator
CS557_RS03500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CS557_RS03515	COG2814	Major facilitator Superfamily
CS557_RS03525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS557_RS03540	COG0745	RESPONSE REGULATOR receiver
CS557_RS03545	COG2205	protein histidine kinase activity
CS557_RS03555	COG3706	GGDEF domain
CS557_RS03560	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CS557_RS03570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CS557_RS03570	COG0649	NAD binding
CS557_RS03580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CS557_RS03595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CS557_RS03610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CS557_RS03615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CS557_RS03635	COG1278	Cold shock
CS557_RS03640	COG0583	DNA-binding transcription factor activity
CS557_RS03645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS557_RS03660	COG0668	transmembrane transport
CS557_RS03670	COG2081	HI0933 family
CS557_RS03680	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CS557_RS03710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS557_RS03720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS557_RS03720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS557_RS03745	COG0489	protein tyrosine kinase activity
CS557_RS03750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CS557_RS03805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CS557_RS03825	COG0730	response to heat
CS557_RS03835	COG1196	nuclear chromosome segregation
CS557_RS03845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CS557_RS03860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CS557_RS03865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CS557_RS03865	COG2226	methyltransferase
CS557_RS03865	COG0596	Alpha beta hydrolase
CS557_RS03880	COG4106	trans-aconitate 2-methyltransferase activity
CS557_RS03920	COG4166	transmembrane transport
CS557_RS03945	COG4172	Belongs to the ABC transporter superfamily
CS557_RS03955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CS557_RS03960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CS557_RS03975	COG0009	L-threonylcarbamoyladenylate synthase
CS557_RS03980	COG3101	peptidyl-lysine hydroxylation
CS557_RS03985	COG1399	metal-binding, possibly nucleic acid-binding protein
CS557_RS03990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CS557_RS04010	COG1652	LysM domain
CS557_RS04015	COG0351	phosphomethylpyrimidine kinase
CS557_RS04015	COG0352	thiamine-phosphate diphosphorylase activity
CS557_RS04015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CS557_RS04025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS557_RS04060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CS557_RS04090	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CS557_RS04105	COG0358	DNA primase activity
CS557_RS04115	COG0564	pseudouridine synthase activity
CS557_RS04140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CS557_RS04165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CS557_RS04165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS557_RS04180	COG1981	membrane
CS557_RS04200	COG0049	tRNA binding
CS557_RS04210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CS557_RS04225	COG0456	acetyltransferase
CS557_RS04235	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CS557_RS04240	COG0500	methyltransferase
CS557_RS04245	COG0492	ferredoxin-NADP+ reductase activity
CS557_RS04250	COG1674	ftsk spoiiie
CS557_RS04255	COG1280	lysine exporter protein (LysE YggA)
CS557_RS04265	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CS557_RS04275	COG0850	regulation of cytokinetic process
CS557_RS04285	COG0204	Acyl-transferase
CS557_RS04290	COG2885	chlorophyll binding
CS557_RS04295	COG0210	DNA helicase
CS557_RS04300	COG0756	dUTP diphosphatase activity
CS557_RS04305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS557_RS04320	COG0121	glutamine amidotransferase
CS557_RS04340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CS557_RS04370	COG0420	3'-5' exonuclease activity
CS557_RS04405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS557_RS04420	COG1566	PFAM secretion protein HlyD family protein
CS557_RS04425	COG2814	Major facilitator Superfamily
CS557_RS04435	COG0789	Transcriptional regulator
CS557_RS04440	COG2217	Heavy metal translocating P-type atpase
CS557_RS04475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS557_RS04480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS557_RS04490	COG1012	belongs to the aldehyde dehydrogenase family
CS557_RS04505	COG0833	amino acid
CS557_RS04510	COG3040	lipid binding
CS557_RS04520	COG3046	protein related to deoxyribodipyrimidine photolyase
CS557_RS04615	COG0725	ABC transporter, periplasmic molybdate-binding protein
CS557_RS04620	COG4149	molybdate abc transporter
CS557_RS04635	COG1230	cation diffusion facilitator family transporter
CS557_RS04645	COG4521	taurine ABC transporter
CS557_RS04650	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CS557_RS04655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS557_RS04660	COG2175	clavaminate synthase activity
CS557_RS04665	COG0589	response to stress
CS557_RS04685	COG0242	peptide deformylase activity
CS557_RS04710	COG0306	phosphate transporter
CS557_RS04725	COG1115	amino acid carrier protein
CS557_RS04730	COG1113	amino acid transport
CS557_RS04740	COG0019	diaminopimelate decarboxylase activity
CS557_RS04745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CS557_RS04755	COG1280	lysine exporter protein (LysE YggA)
CS557_RS04785	COG0842	Transport permease protein
CS557_RS04815	COG1671	Belongs to the UPF0178 family
CS557_RS04830	COG4591	ABC-type transport system involved in lipoprotein release permease component
CS557_RS04835	COG1136	(ABC) transporter
CS557_RS04840	COG0658	competence protein
CS557_RS04840	COG2333	competence protein COMEC
CS557_RS04850	COG0616	signal peptide processing
CS557_RS04850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CS557_RS04860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CS557_RS04870	COG0628	permease
CS557_RS04875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CS557_RS04910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS557_RS04930	COG0823	Involved in the tonB-independent uptake of proteins
CS557_RS04950	COG0824	Thioesterase
CS557_RS04985	COG0047	phosphoribosylformylglycinamidine synthase activity
CS557_RS04985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CS557_RS04990	COG2814	Major facilitator Superfamily
CS557_RS05000	COG3323	Protein of unknown function (DUF1653)
CS557_RS05000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CS557_RS05005	COG0778	Nitroreductase
CS557_RS05010	COG1024	Enoyl-CoA hydratase
CS557_RS05015	COG1056	cytidyltransferase-related domain
CS557_RS05015	COG1051	belongs to the nudix hydrolase family
CS557_RS05025	COG0625	glutathione transferase activity
CS557_RS05030	COG1942	4-Oxalocrotonate Tautomerase
CS557_RS05050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CS557_RS05065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CS557_RS05070	COG0602	queuosine metabolic process
CS557_RS05085	COG0583	DNA-binding transcription factor activity
CS557_RS05090	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CS557_RS05095	COG4208	sulfate ABC transporter
CS557_RS05100	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CS557_RS05110	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CS557_RS05115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS557_RS05120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CS557_RS05135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS557_RS05145	COG0481	GTPase activity
CS557_RS05160	COG0571	ribonuclease III activity
CS557_RS05165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CS557_RS05180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CS557_RS05200	COG0436	Aminotransferase
CS557_RS05225	COG0556	nucleotide-excision repair
CS557_RS05280	COG0583	DNA-binding transcription factor activity
CS557_RS05285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CS557_RS05290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS557_RS05295	COG1773	rubredoxin
CS557_RS05305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CS557_RS05315	COG0175	sulfate reduction
CS557_RS05330	COG0222	ribosome binding
CS557_RS05335	COG1253	flavin adenine dinucleotide binding
CS557_RS05350	COG3015	lipoprotein NlpE involved in copper resistance
CS557_RS05365	COG0517	IMP dehydrogenase activity
CS557_RS05365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS557_RS05370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CS557_RS05380	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CS557_RS05385	COG1137	ATPase activity
CS557_RS05395	COG1538	Outer membrane efflux protein
CS557_RS05410	COG1739	Uncharacterized protein family UPF0029
CS557_RS05435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CS557_RS05460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CS557_RS05485	COG1401	restriction endodeoxyribonuclease activity
CS557_RS05505	COG2175	clavaminate synthase activity
CS557_RS05510	COG3246	L-lysine catabolic process to acetate
CS557_RS05530	COG2855	membrane
CS557_RS05560	COG2828	Protein conserved in bacteria
CS557_RS05565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CS557_RS05570	COG3038	cytochrome b561
CS557_RS05575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS557_RS05585	COG1840	ABC-type Fe3 transport system, periplasmic component
CS557_RS05590	COG3842	ATPase activity
CS557_RS05600	COG1253	flavin adenine dinucleotide binding
CS557_RS05625	COG5002	protein histidine kinase activity
CS557_RS05640	COG2351	hydroxyisourate hydrolase activity
CS557_RS05655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS557_RS05660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CS557_RS05695	COG4783	chaperone-mediated protein folding
CS557_RS05710	COG1610	YqeY-like protein
CS557_RS05730	COG0697	spore germination
CS557_RS05775	COG1414	Transcriptional regulator
CS557_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS05810	COG2271	Major facilitator Superfamily
CS557_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS05840	COG0028	Belongs to the TPP enzyme family
CS557_RS05885	COG0482	sulfurtransferase activity
CS557_RS05900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CS557_RS05905	COG1686	Belongs to the peptidase S11 family
CS557_RS05930	COG0583	DNA-binding transcription factor activity
CS557_RS05935	COG1067	ATP-dependent peptidase activity
CS557_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS05980	COG1509	lysine 2,3-aminomutase activity
CS557_RS05985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CS557_RS05990	COG1966	Carbon starvation protein
CS557_RS05995	COG2879	small protein
CS557_RS06000	COG0714	Associated with various cellular activities
CS557_RS06055	COG1741	Belongs to the pirin family
CS557_RS06065	COG0446	pyridine nucleotide-disulphide oxidoreductase
CS557_RS06065	COG1902	pentaerythritol trinitrate reductase activity
CS557_RS06075	COG2207	Transcriptional regulator
CS557_RS06090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CS557_RS06095	COG0183	Belongs to the thiolase family
CS557_RS06100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS557_RS06105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS557_RS06115	COG4829	muconolactone delta-isomerase
CS557_RS06120	COG4948	Mandelate Racemase Muconate Lactonizing
CS557_RS06125	COG0543	2 iron, 2 sulfur cluster binding
CS557_RS06125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS557_RS06130	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CS557_RS06135	COG4638	Rieske (2fe-2S)
CS557_RS06165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS557_RS06170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CS557_RS06170	COG4451	ribulose bisphosphate carboxylase, small
CS557_RS06175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CS557_RS06180	COG1469	GTP cyclohydrolase I activity
CS557_RS06195	COG0523	cobalamin synthesis protein
CS557_RS06240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CS557_RS06250	COG4106	trans-aconitate 2-methyltransferase activity
CS557_RS06255	COG0642	Histidine kinase
CS557_RS06260	COG0745	RESPONSE REGULATOR receiver
CS557_RS06285	COG2985	domain, Protein
CS557_RS06320	COG1414	Transcriptional regulator
CS557_RS06325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS557_RS06330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS557_RS06335	COG0183	Belongs to the thiolase family
CS557_RS06340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CS557_RS06345	COG0596	Alpha beta hydrolase
CS557_RS06350	COG2271	Major facilitator Superfamily
CS557_RS06355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CS557_RS06360	COG3485	protocatechuate 3,4-dioxygenase
CS557_RS06365	COG3485	protocatechuate 3,4-dioxygenase
CS557_RS06370	COG0710	3-dehydroquinate dehydratase activity
CS557_RS06375	COG3420	alginic acid biosynthetic process
CS557_RS06380	COG3659	wide pore channel activity
CS557_RS06385	COG4993	Dehydrogenase
CS557_RS06395	COG2351	hydroxyisourate hydrolase activity
CS557_RS06400	COG2233	PERMEase
CS557_RS06410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CS557_RS06415	COG2186	Transcriptional regulator
CS557_RS06440	COG0583	DNA-binding transcription factor activity
CS557_RS06450	COG2188	Transcriptional regulator
CS557_RS06480	COG0010	Belongs to the arginase family
CS557_RS06485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS557_RS06505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS557_RS06530	COG0243	molybdopterin cofactor binding
CS557_RS06535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CS557_RS06540	COG1309	transcriptional regulator
CS557_RS06560	COG2072	flavoprotein involved in K transport
CS557_RS06565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CS557_RS06570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CS557_RS06575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CS557_RS06580	COG4770	biotin carboxylase activity
CS557_RS06585	COG0501	Belongs to the peptidase M48B family
CS557_RS06595	COG1765	OsmC-like protein
CS557_RS06645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CS557_RS06685	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS557_RS06705	COG1643	Atp-dependent helicase
CS557_RS06720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CS557_RS06725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS557_RS06750	COG2951	lytic endotransglycosylase activity
CS557_RS06755	COG0772	Belongs to the SEDS family
CS557_RS06770	COG0842	Transport permease protein
CS557_RS06775	COG1131	(ABC) transporter
CS557_RS06780	COG0583	DNA-binding transcription factor activity
CS557_RS06800	COG3659	wide pore channel activity
CS557_RS06855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CS557_RS06860	COG0826	peptidase U32
CS557_RS06870	COG4682	membrane
CS557_RS06885	COG2808	Putative FMN-binding domain
CS557_RS06900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS557_RS06905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS557_RS06915	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CS557_RS06940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CS557_RS06960	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CS557_RS06970	COG0729	surface antigen
CS557_RS07000	COG0471	metal ion transport
CS557_RS07005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS557_RS07015	COG3647	Membrane
CS557_RS07020	COG2814	Major facilitator Superfamily
CS557_RS07025	COG0583	DNA-binding transcription factor activity
CS557_RS07055	COG1720	tRNA m6t6A37 methyltransferase activity
CS557_RS07065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CS557_RS07080	COG0642	Histidine kinase
CS557_RS07090	COG0494	nUDIX hydrolase
CS557_RS07100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS557_RS07110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS557_RS07115	COG3139	Protein of unknown function (DUF1315)
CS557_RS07165	COG1960	acyl-CoA dehydrogenase activity
CS557_RS07180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CS557_RS07190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CS557_RS07195	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS557_RS07200	COG0430	RNA-3'-phosphate cyclase activity
CS557_RS07215	COG1690	Belongs to the RtcB family
CS557_RS07220	COG1234	tRNA 3'-trailer cleavage
CS557_RS07230	COG4650	regulator
CS557_RS07295	COG0513	Belongs to the DEAD box helicase family
CS557_RS07305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS557_RS07315	COG3178	'Phosphotransferase
CS557_RS07320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CS557_RS07330	COG1192	Involved in chromosome partitioning
CS557_RS07335	COG1475	DNA binding
CS557_RS07340	COG0811	peptide transport
CS557_RS07350	COG1132	(ABC) transporter
CS557_RS07355	COG1663	tetraacyldisaccharide 4'-kinase activity
CS557_RS07375	COG0084	hydrolase, TatD family'
CS557_RS07440	COG0776	regulation of translation
CS557_RS07475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CS557_RS07480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CS557_RS07515	COG0024	Methionine aminopeptidase
CS557_RS07520	COG0583	DNA-binding transcription factor activity
CS557_RS07525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS557_RS07535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CS557_RS07540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS557_RS07545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS557_RS07545	COG0517	IMP dehydrogenase activity
CS557_RS07570	COG0552	protein localization to endoplasmic reticulum
CS557_RS07580	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CS557_RS07595	COG4890	Cyd operon protein YbgT
CS557_RS07600	COG1294	oxidase, subunit
CS557_RS07625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS557_RS07645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS557_RS07650	COG0569	domain protein
CS557_RS07655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CS557_RS07660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CS557_RS07685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CS557_RS07690	COG0542	response to heat
CS557_RS07700	COG0488	(ABC) transporter
CS557_RS07705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CS557_RS07710	COG2267	carboxylic ester hydrolase activity
CS557_RS07720	COG0446	pyridine nucleotide-disulphide oxidoreductase
CS557_RS07720	COG1902	pentaerythritol trinitrate reductase activity
CS557_RS07760	COG0148	phosphopyruvate hydratase activity
CS557_RS07765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CS557_RS07805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS557_RS07810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CS557_RS07825	COG1802	Transcriptional regulator
CS557_RS07835	COG2207	Transcriptional regulator
CS557_RS07840	COG1063	alcohol dehydrogenase
CS557_RS07850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS557_RS07870	COG1454	alcohol dehydrogenase
CS557_RS07880	COG2814	Major facilitator Superfamily
CS557_RS07885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CS557_RS07890	COG0183	Belongs to the thiolase family
CS557_RS07895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS557_RS07900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS557_RS07905	COG3135	benzoate transporter
CS557_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS07915	COG0633	Ferredoxin
CS557_RS07915	COG0543	2 iron, 2 sulfur cluster binding
CS557_RS07920	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CS557_RS07925	COG4638	Rieske (2fe-2S)
CS557_RS07935	COG4829	muconolactone delta-isomerase
CS557_RS07945	COG0583	DNA-binding transcription factor activity
CS557_RS07950	COG3618	amidohydrolase
CS557_RS07955	COG1944	ATP diphosphatase activity
CS557_RS07965	COG4221	oxidoreductase activity
CS557_RS07980	COG0439	Biotin carboxylase
CS557_RS07985	COG0864	Transcriptional regulator
CS557_RS07990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS557_RS08000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS557_RS08025	COG0583	DNA-binding transcription factor activity
CS557_RS08035	COG4770	biotin carboxylase activity
CS557_RS08040	COG1024	Enoyl-CoA hydratase
CS557_RS08045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS557_RS08050	COG1960	acyl-CoA dehydrogenase activity
CS557_RS08055	COG1309	transcriptional regulator
CS557_RS08060	COG0318	PFAM AMP-dependent synthetase and ligase
CS557_RS08075	COG2814	Major facilitator Superfamily
CS557_RS08095	COG0583	DNA-binding transcription factor activity
CS557_RS08120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS557_RS08125	COG0730	response to heat
CS557_RS08145	COG4628	conserved protein (DUF2132)
CS557_RS08165	COG1960	acyl-CoA dehydrogenase activity
CS557_RS08175	COG0318	PFAM AMP-dependent synthetase and ligase
CS557_RS08210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS557_RS08305	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS557_RS08315	COG3706	GGDEF domain
CS557_RS08330	COG0133	tryptophan synthase activity
CS557_RS08340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS557_RS08360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CS557_RS08390	COG0537	adenosine 5'-monophosphoramidase activity
CS557_RS08415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS557_RS08435	COG0730	response to heat
CS557_RS08450	COG4771	TonB-dependent receptor
CS557_RS08470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CS557_RS08485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS557_RS08500	COG2223	nitrite transmembrane transporter activity
CS557_RS08530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS557_RS08545	COG1960	acyl-CoA dehydrogenase activity
CS557_RS08550	COG1960	acyl-CoA dehydrogenase activity
CS557_RS08555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS557_RS08560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS557_RS08565	COG2207	Transcriptional regulator
CS557_RS08570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS557_RS08590	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CS557_RS08605	COG0575	Belongs to the CDS family
CS557_RS08610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CS557_RS08615	COG0233	cytoplasmic translational termination
CS557_RS08635	COG3852	Histidine kinase
CS557_RS08640	COG2204	response regulator
CS557_RS08710	COG0697	spore germination
CS557_RS08715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS557_RS08725	COG0303	'Molybdopterin
CS557_RS08730	COG0521	Mo-molybdopterin cofactor biosynthetic process
CS557_RS08730	COG0315	cyclic pyranopterin monophosphate synthase activity
CS557_RS08745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CS557_RS08750	COG0243	molybdopterin cofactor binding
CS557_RS08765	COG0243	molybdopterin cofactor binding
CS557_RS08770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS557_RS08775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS557_RS08775	COG2146	nitrite reductase [NAD(P)H] activity
CS557_RS08780	COG2223	nitrite transmembrane transporter activity
CS557_RS08790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS557_RS08790	COG1116	anion transmembrane transporter activity
CS557_RS08820	COG2814	Major facilitator Superfamily
CS557_RS08825	COG1113	amino acid transport
CS557_RS08835	COG0625	glutathione transferase activity
CS557_RS08855	COG0069	glutamate synthase activity
CS557_RS08890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CS557_RS08895	COG1454	alcohol dehydrogenase
CS557_RS08900	COG0824	Thioesterase
CS557_RS08905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CS557_RS08910	COG2850	peptidyl-arginine hydroxylation
CS557_RS08955	COG3122	Protein conserved in bacteria
CS557_RS08960	COG0668	transmembrane transport
CS557_RS08975	COG1132	(ABC) transporter
CS557_RS08995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS557_RS09005	COG0506	proline dehydrogenase activity
CS557_RS09005	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CS557_RS09005	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CS557_RS09015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS557_RS09025	COG3698	Phosphodiester glycosidase
CS557_RS09035	COG0590	tRNA wobble adenosine to inosine editing
CS557_RS09040	COG3811	Belongs to the UPF0386 family
CS557_RS09050	COG2353	YceI-like domain
CS557_RS09060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CS557_RS09065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CS557_RS09100	COG1278	Cold shock
CS557_RS09120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CS557_RS09120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CS557_RS09145	COG3539	Fimbrial protein
CS557_RS09180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS557_RS09185	COG0753	catalase activity
CS557_RS09190	COG1560	Kdo2-lipid A biosynthetic process
CS557_RS09215	COG0204	Acyl-transferase
CS557_RS09250	COG1464	Belongs to the NlpA lipoprotein family
CS557_RS09260	COG2011	ABC-type metal ion transport system permease component
CS557_RS09265	COG0012	GTP binding
CS557_RS09280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS557_RS09325	COG0386	Belongs to the glutathione peroxidase family
CS557_RS09335	COG0436	Aminotransferase
CS557_RS09370	COG2267	carboxylic ester hydrolase activity
CS557_RS09375	COG3634	alkyl hydroperoxide reductase activity
CS557_RS09425	COG1286	toxin biosynthetic process
CS557_RS09455	COG0778	Nitroreductase
CS557_RS09480	COG0424	maF-like protein
CS557_RS09510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CS557_RS09515	COG2030	dehydratase
CS557_RS09525	COG0183	Belongs to the thiolase family
CS557_RS09540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CS557_RS09545	COG0702	epimerase
CS557_RS09550	COG0268	Binds directly to 16S ribosomal RNA
CS557_RS09570	COG1011	Hydrolase
CS557_RS09575	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CS557_RS09580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CS557_RS09585	COG2137	regulation of response to DNA damage stimulus
CS557_RS09600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS557_RS09630	COG0822	iron-sulfur transferase activity
CS557_RS09635	COG0316	Belongs to the HesB IscA family
CS557_RS09665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CS557_RS09680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CS557_RS09690	COG3135	benzoate transporter
CS557_RS09695	COG0475	glutathione-regulated potassium exporter activity
CS557_RS09695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CS557_RS09710	COG1760	l-serine dehydratase
CS557_RS09715	COG0308	aminopeptidase N
CS557_RS09750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS557_RS09760	COG0531	amino acid
CS557_RS09765	COG4303	Ethanolamine ammonia lyase large subunit
CS557_RS09770	COG4302	ethanolamine ammonia-lyase activity
CS557_RS09775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS557_RS09780	COG0519	Catalyzes the synthesis of GMP from XMP
CS557_RS09780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CS557_RS09785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS557_RS09795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS557_RS09800	COG0778	Nitroreductase
CS557_RS09805	COG0697	spore germination
CS557_RS09810	COG1923	regulation of RNA biosynthetic process
CS557_RS09820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CS557_RS09825	COG0802	atpase or kinase
CS557_RS09860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS557_RS09885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CS557_RS09890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CS557_RS09895	COG1845	cytochrome c oxidase, subunit III
CS557_RS09900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CS557_RS09935	COG0305	Participates in initiation and elongation during chromosome replication
CS557_RS09940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CS557_RS09950	COG1305	Transglutaminase-like
CS557_RS09960	COG2308	Evidence 4 Homologs of previously reported genes of
CS557_RS09970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CS557_RS09985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CS557_RS09995	COG0527	aspartate kinase activity
CS557_RS10005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CS557_RS10020	COG3038	cytochrome b561
CS557_RS10025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CS557_RS10030	COG2252	PERMEase
CS557_RS10085	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CS557_RS10090	COG0138	bifunctional purine biosynthesis protein purh
CS557_RS10095	COG0151	Belongs to the GarS family
CS557_RS10105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS557_RS10110	COG2011	ABC-type metal ion transport system permease component
CS557_RS10135	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CS557_RS10140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CS557_RS10145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CS557_RS10155	COG0281	malic enzyme
CS557_RS10155	COG0280	phosphate acetyltransferase
CS557_RS10170	COG0052	Belongs to the universal ribosomal protein uS2 family
CS557_RS10175	COG0024	Methionine aminopeptidase
CS557_RS10185	COG2223	nitrite transmembrane transporter activity
CS557_RS10195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS557_RS10200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CS557_RS10205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS557_RS10240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CS557_RS10245	COG3161	chorismate lyase activity
CS557_RS10250	COG0174	glutamine synthetase
CS557_RS10255	COG0512	Glutamine amidotransferase of anthranilate synthase
CS557_RS10260	COG1823	symporter activity
CS557_RS10265	COG0633	Ferredoxin
CS557_RS10265	COG3217	Mosc domain protein beta barrel domain protein
CS557_RS10290	COG0302	gtp cyclohydrolase
CS557_RS10310	COG3739	integral membrane protein
CS557_RS10325	COG5001	Diguanylate cyclase
CS557_RS10325	COG4251	negative regulation of phosphorylation
CS557_RS10325	COG2203	Gaf domain
CS557_RS10325	COG3706	GGDEF domain
CS557_RS10335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CS557_RS10355	COG4172	Belongs to the ABC transporter superfamily
CS557_RS10360	COG4239	(ABC) transporter, permease
CS557_RS10365	COG4174	ABC transporter (Permease)
CS557_RS10370	COG4166	transmembrane transport
CS557_RS10375	COG1388	LysM domain
CS557_RS10375	COG0741	lytic transglycosylase activity
CS557_RS10380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CS557_RS10435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CS557_RS10440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CS557_RS10445	COG0006	proline dipeptidase activity
CS557_RS10480	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CS557_RS10490	COG0714	Associated with various cellular activities
CS557_RS10495	COG3831	ATPase activity
CS557_RS10510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CS557_RS10525	COG3384	dioxygenase
CS557_RS10535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS557_RS10540	COG2878	Part of a membrane complex involved in electron transport
CS557_RS10545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CS557_RS10570	COG0768	penicillin binding
CS557_RS10575	COG0742	ribosomal rna small subunit methyltransferase
CS557_RS10600	COG0616	signal peptide processing
CS557_RS10605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CS557_RS10615	COG0573	inorganic phosphate transmembrane transporter activity
CS557_RS10630	COG0076	glutamate decarboxylase activity
CS557_RS10635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS557_RS10645	COG1309	transcriptional regulator
CS557_RS10665	COG1309	transcriptional regulator
CS557_RS10675	COG0783	Belongs to the Dps family
CS557_RS10685	COG0564	pseudouridine synthase activity
CS557_RS10695	COG0352	thiamine-phosphate diphosphorylase activity
CS557_RS10725	COG0612	Peptidase, M16
CS557_RS10740	COG1187	pseudouridine synthase activity
CS557_RS10760	COG1686	Belongs to the peptidase S11 family
CS557_RS10765	COG1252	NADH dehydrogenase
CS557_RS10775	COG0415	Belongs to the DNA photolyase family
CS557_RS10790	COG1215	transferase activity, transferring glycosyl groups
CS557_RS10825	COG1271	oxidase subunit
CS557_RS10830	COG1294	oxidase, subunit
CS557_RS10835	COG2070	2-Nitropropane dioxygenase
CS557_RS10850	COG0705	Rhomboid family
CS557_RS10850	COG0457	Tetratricopeptide repeat
CS557_RS10855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CS557_RS10860	COG4181	ATPase activity
CS557_RS10870	COG0288	reversible hydration of carbon dioxide
CS557_RS10885	COG4771	TonB-dependent receptor
CS557_RS10910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CS557_RS10950	COG1597	lipid kinase activity
CS557_RS10955	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CS557_RS10970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CS557_RS10980	COG2388	GCN5-related N-acetyl-transferase
CS557_RS11020	COG1215	transferase activity, transferring glycosyl groups
CS557_RS11025	COG1649	PFAM Uncharacterised BCR, COG1649
CS557_RS11025	COG0726	polysaccharide deacetylase
CS557_RS11040	COG4681	YaeQ
CS557_RS11045	COG0523	cobalamin synthesis protein
CS557_RS11055	COG1607	acyl-coa hydrolase
CS557_RS11070	COG0583	DNA-binding transcription factor activity
CS557_RS11075	COG1301	dicarboxylic acid transport
CS557_RS11085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CS557_RS11090	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CS557_RS11105	COG0741	lytic transglycosylase activity
CS557_RS11110	COG0501	Belongs to the peptidase M48B family
CS557_RS11120	COG2239	Acts as a magnesium transporter
CS557_RS11130	COG2194	sulfuric ester hydrolase activity
CS557_RS11135	COG0584	glycerophosphoryl diester phosphodiesterase
CS557_RS11140	COG3201	nicotinamide mononucleotide transporter
CS557_RS11160	COG2304	oxidoreductase activity
CS557_RS11165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CS557_RS11170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS557_RS11195	COG0505	Belongs to the CarA family
CS557_RS11215	COG0589	response to stress
CS557_RS11260	COG2321	neutral zinc metallopeptidase
CS557_RS11265	COG2354	Protein conserved in bacteria
CS557_RS11275	COG1585	Membrane protein implicated in regulation of membrane protease activity
CS557_RS11280	COG2268	Band 7 protein
CS557_RS11290	COG1215	transferase activity, transferring glycosyl groups
CS557_RS11295	COG1649	PFAM Uncharacterised BCR, COG1649
CS557_RS11295	COG0726	polysaccharide deacetylase
CS557_RS11315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS557_RS11335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CS557_RS11340	COG1053	succinate dehydrogenase
CS557_RS11345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CS557_RS11350	COG2009	succinate dehydrogenase
CS557_RS11375	COG1054	Belongs to the UPF0176 family
CS557_RS11380	COG0586	Pfam SNARE associated Golgi protein
CS557_RS11385	COG0500	methyltransferase
CS557_RS11395	COG0583	DNA-binding transcription factor activity
CS557_RS11430	COG0321	lipoyl(octanoyl) transferase activity
CS557_RS11445	COG0531	amino acid
CS557_RS11455	COG1733	regulation of RNA biosynthetic process
CS557_RS11460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CS557_RS11465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CS557_RS11465	COG1648	precorrin-2 dehydrogenase activity
CS557_RS11480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CS557_RS11510	COG0671	phosphoesterase, PA-phosphatase related
CS557_RS11515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS557_RS11525	COG1538	Outer membrane efflux protein
CS557_RS11530	COG0393	Putative heavy-metal-binding
CS557_RS11535	COG0393	Putative heavy-metal-binding
CS557_RS11545	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS11560	COG0525	valine-tRNA ligase activity
CS557_RS11575	COG0004	ammonium transporteR
CS557_RS11590	COG0642	Histidine kinase
CS557_RS11595	COG0745	RESPONSE REGULATOR receiver
CS557_RS11600	COG2194	sulfuric ester hydrolase activity
CS557_RS11620	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS557_RS11635	COG2814	Major facilitator Superfamily
CS557_RS11640	COG0142	geranyltranstransferase activity
CS557_RS11650	COG1113	amino acid transport
CS557_RS11665	COG0174	glutamine synthetase
CS557_RS11670	COG0671	phosphoesterase, PA-phosphatase related
CS557_RS11680	COG2851	Citrate transporter
CS557_RS11690	COG0745	RESPONSE REGULATOR receiver
CS557_RS11695	COG2205	protein histidine kinase activity
CS557_RS11700	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CS557_RS11705	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CS557_RS11710	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CS557_RS11735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS557_RS11745	COG1530	ribonuclease E activity
CS557_RS11750	COG0424	maF-like protein
CS557_RS11760	COG1792	Involved in formation and maintenance of cell shape
CS557_RS11765	COG1077	Cell shape determining protein MreB Mrl
CS557_RS11770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CS557_RS11780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CS557_RS11835	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CS557_RS11840	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS557_RS11845	COG1115	amino acid carrier protein
CS557_RS11850	COG0786	glutamate:sodium symporter activity
CS557_RS11865	COG2814	Major facilitator Superfamily
CS557_RS11870	COG1289	transmembrane transporter activity
CS557_RS11880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CS557_RS11925	COG1376	ErfK ybiS ycfS ynhG family protein
CS557_RS11930	COG2832	Protein of unknown function (DUF454)
CS557_RS11940	COG5510	response to toxic substance
CS557_RS11955	COG2198	Histidine kinase
CS557_RS11955	COG0643	Histidine kinase
CS557_RS11955	COG2198	Histidine kinase
CS557_RS11955	COG0643	Histidine kinase
CS557_RS11960	COG0840	transmembrane signaling receptor activity
CS557_RS11990	COG3422	double-strand break repair
CS557_RS11995	COG2824	Alkylphosphonate utilization operon protein PhnA
CS557_RS12000	COG3189	MarR family transcriptional regulator
CS557_RS12010	COG0354	folic acid binding
CS557_RS12025	COG4772	TonB-dependent receptor
CS557_RS12035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS557_RS12045	COG1970	mechanosensitive ion channel activity
CS557_RS12050	COG1217	gtp-binding protein TYPA
CS557_RS12055	COG2233	PERMEase
CS557_RS12065	COG0833	amino acid
CS557_RS12070	COG1690	Belongs to the RtcB family
CS557_RS12075	COG2885	chlorophyll binding
CS557_RS12075	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CS557_RS12085	COG0183	Belongs to the thiolase family
CS557_RS12105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS557_RS12120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CS557_RS12125	COG2207	Transcriptional regulator
CS557_RS12140	COG0183	Belongs to the thiolase family
CS557_RS12145	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS557_RS12145	COG1024	Enoyl-CoA hydratase
CS557_RS12175	COG1272	protein, Hemolysin III
CS557_RS12180	COG0477	Major facilitator Superfamily
CS557_RS12200	COG0450	alkyl hydroperoxide reductase
CS557_RS12225	COG0285	dihydrofolate synthase activity
CS557_RS12280	COG4206	TonB-dependent receptor
CS557_RS12285	COG2096	Adenosyltransferase
CS557_RS12305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CS557_RS12320	COG0745	RESPONSE REGULATOR receiver
CS557_RS12325	COG2205	protein histidine kinase activity
CS557_RS12335	COG1960	acyl-CoA dehydrogenase activity
CS557_RS12340	COG1960	acyl-CoA dehydrogenase activity
CS557_RS12405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CS557_RS12420	COG3306	glycosyltransferase involved in LPS biosynthesis
CS557_RS12450	COG0438	transferase activity, transferring glycosyl groups
CS557_RS12470	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CS557_RS12475	COG2205	protein histidine kinase activity
CS557_RS12475	COG0784	Response regulator, receiver
CS557_RS12490	COG4695	Portal protein
CS557_RS12545	COG4416	COG NOG18757 non supervised orthologous group
CS557_RS12635	COG1598	PFAM Uncharacterised protein family UPF0150
CS557_RS12640	COG1724	mRNA binding
CS557_RS12735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CS557_RS12755	COG1862	Preprotein translocase
CS557_RS12765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS557_RS12835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CS557_RS12840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CS557_RS12845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CS557_RS12860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CS557_RS12870	COG0625	glutathione transferase activity
CS557_RS12875	COG2969	positive regulation of protein catabolic process
CS557_RS12930	COG1960	acyl-CoA dehydrogenase activity
CS557_RS12935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS557_RS12950	COG1309	transcriptional regulator
CS557_RS12965	COG1960	acyl-CoA dehydrogenase activity
CS557_RS12970	COG1960	acyl-CoA dehydrogenase activity
CS557_RS13015	COG1183	phosphatidylcholine synthase activity
CS557_RS13020	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CS557_RS13050	COG0741	lytic transglycosylase activity
CS557_RS13050	COG0739	heme binding
CS557_RS13050	COG1196	nuclear chromosome segregation
CS557_RS13060	COG1702	phosphate starvation-inducible protein PhoH
CS557_RS13075	COG4773	Receptor
CS557_RS13140	COG0788	formyltetrahydrofolate deformylase activity
CS557_RS13165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CS557_RS13165	COG4651	solute:proton antiporter activity
CS557_RS13185	COG0724	RNA recognition motif
CS557_RS13190	COG0210	DNA helicase
CS557_RS13215	COG1733	regulation of RNA biosynthetic process
CS557_RS13220	COG0604	alcohol dehydrogenase
CS557_RS13225	COG2900	Belongs to the SlyX family
CS557_RS13230	COG0488	(ABC) transporter
CS557_RS13240	COG1560	Kdo2-lipid A biosynthetic process
CS557_RS13315	COG0473	3-isopropylmalate dehydrogenase activity
CS557_RS13340	COG0583	DNA-binding transcription factor activity
CS557_RS13365	COG0494	nUDIX hydrolase
CS557_RS13385	COG3011	Protein conserved in bacteria
CS557_RS13400	COG0583	DNA-binding transcription factor activity
CS557_RS13415	COG0546	phosphoglycolate phosphatase activity
CS557_RS13430	COG1530	ribonuclease E activity
CS557_RS13435	COG0318	PFAM AMP-dependent synthetase and ligase
CS557_RS13455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS557_RS13465	COG0534	Mate efflux family protein
CS557_RS13470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CS557_RS13500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS557_RS13515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CS557_RS13515	COG0493	'glutamate synthase
CS557_RS13525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CS557_RS13530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS557_RS13545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CS557_RS13555	COG0644	oxidoreductase
CS557_RS13555	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CS557_RS13565	COG1595	DNA-templated transcription, initiation
CS557_RS13575	COG3220	belongs to the UPF0276 family
CS557_RS13590	COG1279	arginine transmembrane transporter activity
CS557_RS13595	COG0425	Belongs to the sulfur carrier protein TusA family
CS557_RS13600	COG4535	Mg2 and Co2 transporter CorC
CS557_RS13625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CS557_RS13635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CS557_RS13640	COG0484	heat shock protein binding
CS557_RS13645	COG0789	Transcriptional regulator
CS557_RS13650	COG0598	Magnesium transport protein CorA
CS557_RS13655	COG1185	polyribonucleotide nucleotidyltransferase activity
CS557_RS13660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CS557_RS13665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CS557_RS13670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS557_RS13675	COG1074	ATP-dependent DNA helicase activity
CS557_RS13680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CS557_RS13705	COG2226	methyltransferase
CS557_RS13715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CS557_RS13735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CS557_RS13750	COG2111	Na H antiporter
CS557_RS13750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CS557_RS13755	COG1006	Multisubunit Na H antiporter MnhC subunit
CS557_RS13760	COG0651	ATP synthesis coupled electron transport
CS557_RS13765	COG1863	multisubunit Na H antiporter MnhE subunit
CS557_RS13770	COG2212	antiporter activity
CS557_RS13775	COG1320	monovalent cation:proton antiporter activity
CS557_RS13780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CS557_RS13790	COG0195	Participates in both transcription termination and antitermination
CS557_RS13840	COG0237	dephospho-CoA kinase activity
CS557_RS13850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS557_RS13860	COG0497	DNA recombination
CS557_RS13870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CS557_RS13895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CS557_RS13925	COG3706	GGDEF domain
CS557_RS13960	COG1132	(ABC) transporter
CS557_RS13970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS557_RS13990	COG0326	Molecular chaperone. Has ATPase activity
CS557_RS14005	COG2056	Na+-H+ antiporter family
CS557_RS14050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CS557_RS14070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CS557_RS14100	COG0546	phosphoglycolate phosphatase activity
CS557_RS14105	COG1716	ATPase activity
CS557_RS14150	COG0181	hydroxymethylbilane synthase activity
CS557_RS14160	COG3275	phosphorelay sensor kinase activity
CS557_RS14200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS557_RS14205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS557_RS14210	COG0772	Belongs to the SEDS family
CS557_RS14235	COG4974	Belongs to the 'phage' integrase family
CS557_RS14240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CS557_RS14250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CS557_RS14270	COG2197	response regulator
CS557_RS14285	COG0793	Belongs to the peptidase S41A family
CS557_RS14290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CS557_RS14295	COG0795	lipopolysaccharide-transporting ATPase activity
CS557_RS14300	COG0795	lipopolysaccharide-transporting ATPase activity
CS557_RS14335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS557_RS14335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS557_RS14345	COG0004	ammonium transporteR
CS557_RS14350	COG0347	Belongs to the P(II) protein family
CS557_RS14380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CS557_RS14395	COG0318	PFAM AMP-dependent synthetase and ligase
CS557_RS14410	COG2860	membrane
CS557_RS14420	COG1253	flavin adenine dinucleotide binding
CS557_RS14440	COG2814	Major facilitator Superfamily
CS557_RS14455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CS557_RS14460	COG0745	RESPONSE REGULATOR receiver
CS557_RS14465	COG2205	protein histidine kinase activity
CS557_RS14470	COG4452	Inner membrane protein CreD
CS557_RS14495	COG2814	Major facilitator Superfamily
CS557_RS14515	COG0655	NAD(P)H dehydrogenase (quinone) activity
CS557_RS14535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS557_RS14570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CS557_RS14590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS557_RS14595	COG3162	membrane
CS557_RS14600	COG0784	Response regulator, receiver
CS557_RS14600	COG2205	protein histidine kinase activity
CS557_RS14625	COG1652	LysM domain
CS557_RS14630	COG0758	DNA mediated transformation
CS557_RS14645	COG1309	transcriptional regulator
CS557_RS14660	COG0386	Belongs to the glutathione peroxidase family
CS557_RS14675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CS557_RS14715	COG0803	Belongs to the bacterial solute-binding protein 9 family
CS557_RS14725	COG1121	(ABC) transporter
CS557_RS14730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CS557_RS14740	COG2837	iron assimilation
CS557_RS14745	COG0281	malic enzyme
CS557_RS14780	COG0519	Catalyzes the synthesis of GMP from XMP
CS557_RS14780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CS557_RS14785	COG4399	Belongs to the UPF0754 family
CS557_RS14795	COG2259	Doxx family
CS557_RS14800	COG0586	Pfam SNARE associated Golgi protein
CS557_RS14815	COG1192	Involved in chromosome partitioning
CS557_RS14825	COG0271	Belongs to the BolA IbaG family
CS557_RS14840	COG0477	Major facilitator Superfamily
CS557_RS14845	COG1024	Enoyl-CoA hydratase
CS557_RS14850	COG1024	Enoyl-CoA hydratase
CS557_RS14855	COG1960	acyl-CoA dehydrogenase activity
CS557_RS14860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS557_RS14880	COG1113	amino acid transport
CS557_RS14885	COG0251	oxidation-reduction process
CS557_RS14920	COG0564	pseudouridine synthase activity
CS557_RS14980	COG1802	Transcriptional regulator
CS557_RS14985	COG1448	Aminotransferase
CS557_RS14990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS557_RS15005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS557_RS15020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS557_RS15050	COG1086	Polysaccharide biosynthesis protein
CS557_RS15055	COG0438	transferase activity, transferring glycosyl groups
CS557_RS15080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS557_RS15085	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CS557_RS15090	COG1596	polysaccharide export
CS557_RS15110	COG0545	Peptidyl-prolyl cis-trans isomerase
CS557_RS15115	COG0728	peptidoglycan biosynthetic process
CS557_RS15120	COG3023	N-Acetylmuramoyl-L-alanine amidase
CS557_RS15140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CS557_RS15175	COG0546	phosphoglycolate phosphatase activity
CS557_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
CS557_RS15190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CS557_RS15190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CS557_RS15195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS557_RS15200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS557_RS15205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS557_RS15210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS557_RS15215	COG1116	anion transmembrane transporter activity
CS557_RS15220	COG1309	transcriptional regulator
CS557_RS15235	COG0196	riboflavin kinase activity
CS557_RS15240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CS557_RS15250	COG1047	Peptidyl-prolyl cis-trans
CS557_RS15290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CS557_RS15295	COG0657	acetylesterase activity
CS557_RS15310	COG0583	DNA-binding transcription factor activity
CS557_RS15320	COG0443	Heat shock 70 kDa protein
CS557_RS15325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CS557_RS15350	COG2951	lytic endotransglycosylase activity
CS557_RS15355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CS557_RS15375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CS557_RS15395	COG1960	acyl-CoA dehydrogenase activity
CS557_RS15400	COG0583	DNA-binding transcription factor activity
CS557_RS15410	COG0861	Integral membrane protein TerC family
CS557_RS15420	COG0754	glutathionylspermidine amidase activity
CS557_RS15430	COG0402	S-adenosylhomocysteine deaminase activity
CS557_RS15465	COG0706	membrane insertase activity