locus-tag	class	description
HLV59_RS00010	COG0592	DNA-directed DNA polymerase activity
HLV59_RS00020	COG0187	DNA topoisomerase II activity
HLV59_RS00035	COG0488	(ABC) transporter
HLV59_RS00060	COG0596	Alpha beta hydrolase
HLV59_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HLV59_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLV59_RS00100	COG0625	glutathione transferase activity
HLV59_RS00110	COG0733	neurotransmitter:sodium symporter activity
HLV59_RS00150	COG2233	PERMEase
HLV59_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLV59_RS00200	COG2814	Major facilitator Superfamily
HLV59_RS00205	COG0656	L-ascorbic acid biosynthetic process
HLV59_RS00210	COG0583	DNA-binding transcription factor activity
HLV59_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLV59_RS00230	COG1064	alcohol dehydrogenase
HLV59_RS00235	COG2818	Glycosylase
HLV59_RS00250	COG1194	a g-specific adenine glycosylase
HLV59_RS00265	COG5487	UPF0391 membrane protein
HLV59_RS00270	COG2983	Belongs to the UPF0260 family
HLV59_RS00275	COG2133	pyrroloquinoline quinone binding
HLV59_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLV59_RS00285	COG2116	formate transmembrane transporter activity
HLV59_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLV59_RS00310	COG1335	isochorismatase
HLV59_RS00315	COG0385	Bile acid
HLV59_RS00320	COG0534	Mate efflux family protein
HLV59_RS00325	COG1683	Conserved Protein
HLV59_RS00340	COG0346	lactoylglutathione lyase activity
HLV59_RS00345	COG0625	glutathione transferase activity
HLV59_RS00355	COG1113	amino acid transport
HLV59_RS00365	COG0523	cobalamin synthesis protein
HLV59_RS00375	COG2188	Transcriptional regulator
HLV59_RS00405	COG0010	Belongs to the arginase family
HLV59_RS00415	COG0546	phosphoglycolate phosphatase activity
HLV59_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLV59_RS00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLV59_RS00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLV59_RS00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HLV59_RS00550	COG0534	Mate efflux family protein
HLV59_RS00555	COG0436	Aminotransferase
HLV59_RS00560	COG2733	membrane
HLV59_RS00575	COG2918	glutathione biosynthetic process
HLV59_RS00585	COG3501	Rhs element vgr protein
HLV59_RS00610	COG3150	esterase
HLV59_RS00620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HLV59_RS00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLV59_RS00640	COG2233	PERMEase
HLV59_RS00645	COG2351	hydroxyisourate hydrolase activity
HLV59_RS00680	COG3706	GGDEF domain
HLV59_RS00695	COG1393	Belongs to the ArsC family
HLV59_RS00700	COG0708	Exodeoxyribonuclease III
HLV59_RS00730	COG0189	ligase activity
HLV59_RS00750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLV59_RS00760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLV59_RS00775	COG4942	peptidase
HLV59_RS00785	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLV59_RS00795	COG2119	membrane
HLV59_RS00800	COG4774	siderophore transport
HLV59_RS00805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLV59_RS00805	COG0426	domain, Protein
HLV59_RS00825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLV59_RS00850	COG1902	pentaerythritol trinitrate reductase activity
HLV59_RS00855	COG1519	Transferase
HLV59_RS00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLV59_RS00865	COG0668	transmembrane transport
HLV59_RS00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLV59_RS00880	COG1335	isochorismatase
HLV59_RS00885	COG1522	sequence-specific DNA binding
HLV59_RS00910	COG0784	Response regulator, receiver
HLV59_RS00910	COG2198	Histidine kinase
HLV59_RS00910	COG2205	protein histidine kinase activity
HLV59_RS00915	COG3162	membrane
HLV59_RS00920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLV59_RS00930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLV59_RS00940	COG3706	GGDEF domain
HLV59_RS00950	COG1309	transcriptional regulator
HLV59_RS00970	COG0300	oxidoreductase activity
HLV59_RS00980	COG0352	thiamine-phosphate diphosphorylase activity
HLV59_RS00980	COG0351	phosphomethylpyrimidine kinase
HLV59_RS00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLV59_RS00990	COG2814	Major facilitator Superfamily
HLV59_RS01005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLV59_RS01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLV59_RS01030	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS01040	COG1335	isochorismatase
HLV59_RS01120	COG0667	Aldo Keto reductase
HLV59_RS01130	COG1309	transcriptional regulator
HLV59_RS01155	COG1733	regulation of RNA biosynthetic process
HLV59_RS01160	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLV59_RS01175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLV59_RS01190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLV59_RS01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLV59_RS01260	COG0697	spore germination
HLV59_RS01270	COG4619	ABC transporter
HLV59_RS01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLV59_RS01320	COG0427	acetyl-CoA hydrolase
HLV59_RS01330	COG2205	protein histidine kinase activity
HLV59_RS01335	COG0745	RESPONSE REGULATOR receiver
HLV59_RS01345	COG0659	secondary active sulfate transmembrane transporter activity
HLV59_RS01350	COG4221	oxidoreductase activity
HLV59_RS01355	COG2873	o-acetylhomoserine
HLV59_RS01360	COG0488	(ABC) transporter
HLV59_RS01440	COG0833	amino acid
HLV59_RS01485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLV59_RS01490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLV59_RS01505	COG2226	methyltransferase
HLV59_RS01555	COG0070	glutamate synthase
HLV59_RS01555	COG0067	glutamate synthase
HLV59_RS01555	COG0069	glutamate synthase activity
HLV59_RS01560	COG0493	'glutamate synthase
HLV59_RS01570	COG1704	LemA family
HLV59_RS01575	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HLV59_RS01595	COG3307	-O-antigen
HLV59_RS01615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLV59_RS01630	COG0194	GDP metabolic process
HLV59_RS01680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLV59_RS01690	COG0335	large ribosomal subunit rRNA binding
HLV59_RS01700	COG5380	lipid catabolic process
HLV59_RS01705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLV59_RS01725	COG5006	permease, DMT superfamily
HLV59_RS01730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLV59_RS01735	COG0277	FAD linked oxidase domain protein
HLV59_RS01745	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HLV59_RS01750	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLV59_RS01765	COG1289	transmembrane transporter activity
HLV59_RS01775	COG0628	permease
HLV59_RS01780	COG1192	Involved in chromosome partitioning
HLV59_RS01810	COG0833	amino acid
HLV59_RS01815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLV59_RS01820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLV59_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS01855	COG1404	Belongs to the peptidase S8 family
HLV59_RS01870	COG0583	DNA-binding transcription factor activity
HLV59_RS01895	COG0752	glycyl-tRNA synthetase alpha subunit
HLV59_RS01920	COG0517	IMP dehydrogenase activity
HLV59_RS01920	COG0617	tRNA 3'-terminal CCA addition
HLV59_RS01920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLV59_RS01925	COG1983	PspC domain protein
HLV59_RS01935	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS01950	COG0408	coproporphyrinogen oxidase activity
HLV59_RS01970	COG0513	Belongs to the DEAD box helicase family
HLV59_RS01980	COG1127	ABC transporter
HLV59_RS01985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLV59_RS01995	COG2854	intermembrane phospholipid transfer
HLV59_RS02005	COG0598	Magnesium transport protein CorA
HLV59_RS02015	COG0494	nUDIX hydrolase
HLV59_RS02020	COG1040	competence protein
HLV59_RS02025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLV59_RS02040	COG2937	Belongs to the GPAT DAPAT family
HLV59_RS02045	COG1946	Acyl-CoA thioesterase
HLV59_RS02050	COG1301	dicarboxylic acid transport
HLV59_RS02065	COG1959	2 iron, 2 sulfur cluster binding
HLV59_RS02070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLV59_RS02070	COG1017	nitric oxide dioxygenase activity
HLV59_RS02080	COG0433	COG0433 Predicted ATPase
HLV59_RS02085	COG0626	cystathionine gamma-synthase activity
HLV59_RS02100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLV59_RS02105	COG0088	Forms part of the polypeptide exit tunnel
HLV59_RS02240	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS02245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HLV59_RS02275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HLV59_RS02280	COG0339	signal peptide processing
HLV59_RS02285	COG0557	exoribonuclease II activity
HLV59_RS02330	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLV59_RS02335	COG1295	ribonuclease BN
HLV59_RS02370	COG1702	phosphate starvation-inducible protein PhoH
HLV59_RS02380	COG0739	heme binding
HLV59_RS02380	COG1196	nuclear chromosome segregation
HLV59_RS02380	COG0741	lytic transglycosylase activity
HLV59_RS02410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HLV59_RS02415	COG1183	phosphatidylcholine synthase activity
HLV59_RS02460	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS02465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLV59_RS02470	COG1309	transcriptional regulator
HLV59_RS02485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLV59_RS02490	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS02510	COG2969	positive regulation of protein catabolic process
HLV59_RS02520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLV59_RS02525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLV59_RS02530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLV59_RS02535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLV59_RS02540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLV59_RS02560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLV59_RS02570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLV59_RS02575	COG1408	metallophosphoesterase
HLV59_RS02580	COG2885	chlorophyll binding
HLV59_RS02580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HLV59_RS02585	COG2199	diguanylate cyclase activity
HLV59_RS02630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLV59_RS02655	COG1607	acyl-coa hydrolase
HLV59_RS02690	COG2350	Protein conserved in bacteria
HLV59_RS02705	COG3781	membrane
HLV59_RS02715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLV59_RS02730	COG1862	Preprotein translocase
HLV59_RS02755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLV59_RS02775	COG0726	polysaccharide deacetylase
HLV59_RS02780	COG0463	Glycosyl transferase, family 2
HLV59_RS02785	COG0438	transferase activity, transferring glycosyl groups
HLV59_RS02845	COG0625	glutathione transferase activity
HLV59_RS02850	COG0583	DNA-binding transcription factor activity
HLV59_RS02855	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS02860	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS02870	COG2205	protein histidine kinase activity
HLV59_RS02875	COG0745	RESPONSE REGULATOR receiver
HLV59_RS02885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLV59_RS02905	COG2096	Adenosyltransferase
HLV59_RS02910	COG4206	TonB-dependent receptor
HLV59_RS02955	COG0285	dihydrofolate synthase activity
HLV59_RS02980	COG0450	alkyl hydroperoxide reductase
HLV59_RS02995	COG0477	Major facilitator Superfamily
HLV59_RS03000	COG1272	protein, Hemolysin III
HLV59_RS03010	COG2153	protein acetylation
HLV59_RS03030	COG0183	Belongs to the thiolase family
HLV59_RS03035	COG2207	Transcriptional regulator
HLV59_RS03055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLV59_RS03075	COG0183	Belongs to the thiolase family
HLV59_RS03085	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HLV59_RS03085	COG2885	chlorophyll binding
HLV59_RS03095	COG1690	Belongs to the RtcB family
HLV59_RS03100	COG0833	amino acid
HLV59_RS03110	COG2233	PERMEase
HLV59_RS03140	COG2094	Belongs to the DNA glycosylase MPG family
HLV59_RS03145	COG4772	TonB-dependent receptor
HLV59_RS03150	COG1902	pentaerythritol trinitrate reductase activity
HLV59_RS03155	COG0679	Auxin Efflux Carrier
HLV59_RS03165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLV59_RS03170	COG0354	folic acid binding
HLV59_RS03185	COG3189	MarR family transcriptional regulator
HLV59_RS03190	COG2824	Alkylphosphonate utilization operon protein PhnA
HLV59_RS03195	COG3422	double-strand break repair
HLV59_RS03235	COG0840	transmembrane signaling receptor activity
HLV59_RS03250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLV59_RS03265	COG5510	response to toxic substance
HLV59_RS03275	COG2832	Protein of unknown function (DUF454)
HLV59_RS03280	COG1376	ErfK ybiS ycfS ynhG family protein
HLV59_RS03320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLV59_RS03330	COG1289	transmembrane transporter activity
HLV59_RS03335	COG2814	Major facilitator Superfamily
HLV59_RS03355	COG1115	amino acid carrier protein
HLV59_RS03360	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLV59_RS03365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLV59_RS03370	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HLV59_RS03395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLV59_RS03405	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLV59_RS03410	COG1077	Cell shape determining protein MreB Mrl
HLV59_RS03415	COG1792	Involved in formation and maintenance of cell shape
HLV59_RS03420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HLV59_RS03425	COG0424	maF-like protein
HLV59_RS03430	COG1530	ribonuclease E activity
HLV59_RS03440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLV59_RS03460	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLV59_RS03485	COG2207	Transcriptional regulator
HLV59_RS03510	COG1113	amino acid transport
HLV59_RS03520	COG0142	geranyltranstransferase activity
HLV59_RS03525	COG2315	Protein conserved in bacteria
HLV59_RS03540	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLV59_RS03565	COG2194	sulfuric ester hydrolase activity
HLV59_RS03570	COG0745	RESPONSE REGULATOR receiver
HLV59_RS03575	COG0642	Histidine kinase
HLV59_RS03585	COG0004	ammonium transporteR
HLV59_RS03590	COG0583	DNA-binding transcription factor activity
HLV59_RS03610	COG0525	valine-tRNA ligase activity
HLV59_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS03630	COG0393	Putative heavy-metal-binding
HLV59_RS03635	COG0393	Putative heavy-metal-binding
HLV59_RS03640	COG1538	Outer membrane efflux protein
HLV59_RS03650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLV59_RS03655	COG0671	phosphoesterase, PA-phosphatase related
HLV59_RS03680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLV59_RS03695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLV59_RS03695	COG1648	precorrin-2 dehydrogenase activity
HLV59_RS03700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLV59_RS03735	COG0531	amino acid
HLV59_RS03750	COG0321	lipoyl(octanoyl) transferase activity
HLV59_RS03755	COG2921	Belongs to the UPF0250 family
HLV59_RS03795	COG2009	succinate dehydrogenase
HLV59_RS03800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HLV59_RS03805	COG1053	succinate dehydrogenase
HLV59_RS03810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLV59_RS03835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLV59_RS03855	COG2354	Protein conserved in bacteria
HLV59_RS03860	COG2321	neutral zinc metallopeptidase
HLV59_RS03880	COG2843	Capsule synthesis protein
HLV59_RS03895	COG0589	response to stress
HLV59_RS03915	COG0505	Belongs to the CarA family
HLV59_RS03945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLV59_RS03950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLV59_RS04000	COG0477	Major facilitator Superfamily
HLV59_RS04005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLV59_RS04020	COG1597	lipid kinase activity
HLV59_RS04025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLV59_RS04055	COG0584	glycerophosphoryl diester phosphodiesterase
HLV59_RS04075	COG0741	lytic transglycosylase activity
HLV59_RS04090	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HLV59_RS04095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLV59_RS04110	COG1940	carbohydrate kinase activity
HLV59_RS04120	COG1309	transcriptional regulator
HLV59_RS04125	COG1902	pentaerythritol trinitrate reductase activity
HLV59_RS04130	COG0596	Alpha beta hydrolase
HLV59_RS04130	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLV59_RS04135	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLV59_RS04135	COG0596	Alpha beta hydrolase
HLV59_RS04140	COG0596	Alpha beta hydrolase
HLV59_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS04150	COG0583	DNA-binding transcription factor activity
HLV59_RS04155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HLV59_RS04160	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLV59_RS04190	COG0778	Nitroreductase
HLV59_RS04205	COG1929	Belongs to the glycerate kinase type-1 family
HLV59_RS04210	COG0243	molybdopterin cofactor binding
HLV59_RS04215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLV59_RS04220	COG3339	Conserved Protein
HLV59_RS04245	COG1115	amino acid carrier protein
HLV59_RS04250	COG1113	amino acid transport
HLV59_RS04260	COG0019	diaminopimelate decarboxylase activity
HLV59_RS04270	COG1280	lysine exporter protein (LysE YggA)
HLV59_RS04275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLV59_RS04305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLV59_RS04340	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLV59_RS04345	COG1136	(ABC) transporter
HLV59_RS04350	COG0658	competence protein
HLV59_RS04350	COG2333	competence protein COMEC
HLV59_RS04360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLV59_RS04360	COG0616	signal peptide processing
HLV59_RS04365	COG0596	Alpha beta hydrolase
HLV59_RS04370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLV59_RS04380	COG0628	permease
HLV59_RS04415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLV59_RS04435	COG0823	Involved in the tonB-independent uptake of proteins
HLV59_RS04455	COG0824	Thioesterase
HLV59_RS04460	COG1473	amidohydrolase
HLV59_RS04480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLV59_RS04480	COG0047	phosphoribosylformylglycinamidine synthase activity
HLV59_RS04485	COG2814	Major facilitator Superfamily
HLV59_RS04490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLV59_RS04495	COG1024	Enoyl-CoA hydratase
HLV59_RS04500	COG1051	belongs to the nudix hydrolase family
HLV59_RS04500	COG1056	cytidyltransferase-related domain
HLV59_RS04515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLV59_RS04530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLV59_RS04535	COG0602	queuosine metabolic process
HLV59_RS04545	COG4625	pathogenesis
HLV59_RS04550	COG0583	DNA-binding transcription factor activity
HLV59_RS04555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HLV59_RS04560	COG4208	sulfate ABC transporter
HLV59_RS04565	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLV59_RS04575	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HLV59_RS04580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLV59_RS04585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLV59_RS04605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLV59_RS04615	COG0481	GTPase activity
HLV59_RS04620	COG0681	Belongs to the peptidase S26 family
HLV59_RS04630	COG0571	ribonuclease III activity
HLV59_RS04635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLV59_RS04645	COG1381	Involved in DNA repair and RecF pathway recombination
HLV59_RS04650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HLV59_RS04660	COG4221	oxidoreductase activity
HLV59_RS04690	COG0436	Aminotransferase
HLV59_RS04710	COG0556	nucleotide-excision repair
HLV59_RS04720	COG2962	Rard protein
HLV59_RS04765	COG2070	2-Nitropropane dioxygenase
HLV59_RS04790	COG1215	transferase activity, transferring glycosyl groups
HLV59_RS04805	COG0415	Belongs to the DNA photolyase family
HLV59_RS04815	COG1252	NADH dehydrogenase
HLV59_RS04820	COG1686	Belongs to the peptidase S11 family
HLV59_RS04835	COG1187	pseudouridine synthase activity
HLV59_RS04850	COG0477	Major facilitator Superfamily
HLV59_RS04855	COG0583	DNA-binding transcription factor activity
HLV59_RS04870	COG0612	Peptidase, M16
HLV59_RS04895	COG0352	thiamine-phosphate diphosphorylase activity
HLV59_RS04930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLV59_RS04955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLV59_RS04960	COG0076	glutamate decarboxylase activity
HLV59_RS04970	COG1522	sequence-specific DNA binding
HLV59_RS04975	COG3961	Belongs to the TPP enzyme family
HLV59_RS04980	COG1113	amino acid transport
HLV59_RS04985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLV59_RS04990	COG0573	inorganic phosphate transmembrane transporter activity
HLV59_RS05000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLV59_RS05005	COG0616	signal peptide processing
HLV59_RS05040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLV59_RS05045	COG1686	Belongs to the peptidase S11 family
HLV59_RS05070	COG0583	DNA-binding transcription factor activity
HLV59_RS05075	COG1067	ATP-dependent peptidase activity
HLV59_RS05080	COG2211	Major facilitator Superfamily
HLV59_RS05115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLV59_RS05120	COG1966	Carbon starvation protein
HLV59_RS05125	COG2879	small protein
HLV59_RS05135	COG0582	viral genome integration into host DNA
HLV59_RS05190	COG0583	DNA-binding transcription factor activity
HLV59_RS05195	COG0006	proline dipeptidase activity
HLV59_RS05200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLV59_RS05205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLV59_RS05215	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS05220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLV59_RS05225	COG0723	plastoquinol--plastocyanin reductase activity
HLV59_RS05225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLV59_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS05285	COG1741	Belongs to the pirin family
HLV59_RS05300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLV59_RS05305	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLV59_RS05310	COG4605	iron ion homeostasis
HLV59_RS05315	COG4604	ABC transporter, ATP-binding protein
HLV59_RS05320	COG4607	ABC-type enterochelin transport system periplasmic component
HLV59_RS05325	COG4774	siderophore transport
HLV59_RS05335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLV59_RS05340	COG1021	2,3-dihydroxybenzoate-AMP ligase
HLV59_RS05345	COG1535	isochorismatase
HLV59_RS05345	COG3433	isochorismatase activity
HLV59_RS05360	COG1132	(ABC) transporter
HLV59_RS05365	COG5265	(ABC) transporter
HLV59_RS05370	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HLV59_RS05380	COG1169	isochorismate synthase
HLV59_RS05395	COG3739	integral membrane protein
HLV59_RS05425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLV59_RS05450	COG0512	Glutamine amidotransferase of anthranilate synthase
HLV59_RS05465	COG3104	oligopeptide transport
HLV59_RS05470	COG0174	glutamine synthetase
HLV59_RS05480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLV59_RS05515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLV59_RS05520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLV59_RS05525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLV59_RS05545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLV59_RS05550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLV59_RS05555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HLV59_RS05570	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS05575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLV59_RS05580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLV59_RS05590	COG2223	nitrite transmembrane transporter activity
HLV59_RS05600	COG0024	Methionine aminopeptidase
HLV59_RS05605	COG0052	Belongs to the universal ribosomal protein uS2 family
HLV59_RS05620	COG2207	Transcriptional regulator
HLV59_RS05645	COG2951	lytic endotransglycosylase activity
HLV59_RS05650	COG0772	Belongs to the SEDS family
HLV59_RS05665	COG0842	Transport permease protein
HLV59_RS05670	COG1131	(ABC) transporter
HLV59_RS05845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLV59_RS05855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLV59_RS05860	COG4215	(ABC) transporter
HLV59_RS05865	COG4160	amino acid transport
HLV59_RS05870	COG4598	ABC transporter
HLV59_RS05880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLV59_RS05890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLV59_RS05895	COG0384	phenazine biosynthesis protein PhzF
HLV59_RS05905	COG1720	tRNA m6t6A37 methyltransferase activity
HLV59_RS05925	COG0745	RESPONSE REGULATOR receiver
HLV59_RS05930	COG0642	Histidine kinase
HLV59_RS05940	COG0494	nUDIX hydrolase
HLV59_RS05950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLV59_RS05955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLV59_RS05960	COG3139	Protein of unknown function (DUF1315)
HLV59_RS05965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLV59_RS05970	COG1301	dicarboxylic acid transport
HLV59_RS05975	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS05995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLV59_RS06005	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLV59_RS06025	COG1690	Belongs to the RtcB family
HLV59_RS06030	COG1234	tRNA 3'-trailer cleavage
HLV59_RS06035	COG4650	regulator
HLV59_RS06060	COG2363	Small membrane protein
HLV59_RS06080	COG0513	Belongs to the DEAD box helicase family
HLV59_RS06090	COG0778	Nitroreductase
HLV59_RS06120	COG1286	toxin biosynthetic process
HLV59_RS06145	COG4783	chaperone-mediated protein folding
HLV59_RS06150	COG1610	YqeY-like protein
HLV59_RS06205	COG1278	Cold shock
HLV59_RS06230	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLV59_RS06235	COG1335	isochorismatase
HLV59_RS06240	COG0583	DNA-binding transcription factor activity
HLV59_RS06245	COG0786	glutamate:sodium symporter activity
HLV59_RS06250	COG0475	glutathione-regulated potassium exporter activity
HLV59_RS06250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLV59_RS06265	COG1309	transcriptional regulator
HLV59_RS06275	COG2985	domain, Protein
HLV59_RS06285	COG2995	paraquat-inducible protein a
HLV59_RS06290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLV59_RS06290	COG3008	intermembrane lipid transfer
HLV59_RS06300	COG2351	hydroxyisourate hydrolase activity
HLV59_RS06315	COG5002	protein histidine kinase activity
HLV59_RS06340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLV59_RS06350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLV59_RS06355	COG0642	Histidine kinase
HLV59_RS06360	COG0745	RESPONSE REGULATOR receiver
HLV59_RS06380	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HLV59_RS06385	COG1794	racemase activity, acting on amino acids and derivatives
HLV59_RS06395	COG2175	clavaminate synthase activity
HLV59_RS06400	COG3246	L-lysine catabolic process to acetate
HLV59_RS06405	COG2814	Major facilitator Superfamily
HLV59_RS06420	COG2855	membrane
HLV59_RS06455	COG2814	Major facilitator Superfamily
HLV59_RS06480	COG1301	dicarboxylic acid transport
HLV59_RS06490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLV59_RS06495	COG2011	ABC-type metal ion transport system permease component
HLV59_RS06500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLV59_RS06510	COG0151	Belongs to the GarS family
HLV59_RS06520	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HLV59_RS06575	COG2308	Evidence 4 Homologs of previously reported genes of
HLV59_RS06585	COG1305	Transglutaminase-like
HLV59_RS06595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLV59_RS06600	COG0305	Participates in initiation and elongation during chromosome replication
HLV59_RS06625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HLV59_RS06635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLV59_RS06665	COG1649	PFAM Uncharacterised BCR, COG1649
HLV59_RS06665	COG0726	polysaccharide deacetylase
HLV59_RS06670	COG1215	transferase activity, transferring glycosyl groups
HLV59_RS06675	COG3658	cytochrome
HLV59_RS06685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLV59_RS06700	COG0583	DNA-binding transcription factor activity
HLV59_RS06715	COG2890	protein-(glutamine-N5) methyltransferase activity
HLV59_RS06720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLV59_RS06725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLV59_RS06740	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS06745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLV59_RS06750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLV59_RS06760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLV59_RS06770	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HLV59_RS06775	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HLV59_RS06785	COG2205	protein histidine kinase activity
HLV59_RS06790	COG0745	RESPONSE REGULATOR receiver
HLV59_RS06795	COG0174	glutamine synthetase
HLV59_RS06810	COG0477	Major facilitator Superfamily
HLV59_RS06815	COG0729	surface antigen
HLV59_RS06855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLV59_RS06860	COG2814	Major facilitator Superfamily
HLV59_RS06870	COG0583	DNA-binding transcription factor activity
HLV59_RS06885	COG1187	pseudouridine synthase activity
HLV59_RS06905	COG0802	atpase or kinase
HLV59_RS06910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLV59_RS06920	COG1923	regulation of RNA biosynthetic process
HLV59_RS06925	COG0697	spore germination
HLV59_RS06935	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLV59_RS06945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLV59_RS06950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLV59_RS06950	COG0519	Catalyzes the synthesis of GMP from XMP
HLV59_RS06955	COG4302	ethanolamine ammonia-lyase activity
HLV59_RS06960	COG4303	Ethanolamine ammonia lyase large subunit
HLV59_RS06965	COG0531	amino acid
HLV59_RS06985	COG1454	alcohol dehydrogenase
HLV59_RS06990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLV59_RS07000	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HLV59_RS07020	COG0308	aminopeptidase N
HLV59_RS07060	COG1605	Chorismate mutase
HLV59_RS07070	COG4772	TonB-dependent receptor
HLV59_RS07075	COG4774	siderophore transport
HLV59_RS07120	COG3772	lysozyme
HLV59_RS07145	COG0583	DNA-binding transcription factor activity
HLV59_RS07190	COG0488	(ABC) transporter
HLV59_RS07195	COG0589	response to stress
HLV59_RS07215	COG3135	benzoate transporter
HLV59_RS07220	COG1522	sequence-specific DNA binding
HLV59_RS07230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLV59_RS07235	COG0583	DNA-binding transcription factor activity
HLV59_RS07245	COG0183	Belongs to the thiolase family
HLV59_RS07250	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS07255	COG2030	dehydratase
HLV59_RS07285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLV59_RS07295	COG0824	Thioesterase
HLV59_RS07300	COG1454	alcohol dehydrogenase
HLV59_RS07310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLV59_RS07340	COG0069	glutamate synthase activity
HLV59_RS07365	COG2814	Major facilitator Superfamily
HLV59_RS07375	COG0439	Biotin carboxylase
HLV59_RS07380	COG0511	ligase activity, forming carbon-carbon bonds
HLV59_RS07400	COG4264	IucA IucC family
HLV59_RS07410	COG2814	Major facilitator Superfamily
HLV59_RS07415	COG4264	IucA IucC family
HLV59_RS07420	COG4264	IucA IucC family
HLV59_RS07430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLV59_RS07445	COG1116	anion transmembrane transporter activity
HLV59_RS07445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLV59_RS07460	COG2146	nitrite reductase [NAD(P)H] activity
HLV59_RS07460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLV59_RS07465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLV59_RS07470	COG0243	molybdopterin cofactor binding
HLV59_RS07480	COG0243	molybdopterin cofactor binding
HLV59_RS07485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLV59_RS07500	COG0315	cyclic pyranopterin monophosphate synthase activity
HLV59_RS07500	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLV59_RS07505	COG0303	'Molybdopterin
HLV59_RS07515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLV59_RS07520	COG0697	spore germination
HLV59_RS07545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLV59_RS07610	COG2204	response regulator
HLV59_RS07615	COG3852	Histidine kinase
HLV59_RS07640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLV59_RS07645	COG0575	Belongs to the CDS family
HLV59_RS07660	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLV59_RS07680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLV59_RS07695	COG2137	regulation of response to DNA damage stimulus
HLV59_RS07705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLV59_RS07710	COG1011	Hydrolase
HLV59_RS07725	COG1522	sequence-specific DNA binding
HLV59_RS07735	COG1113	amino acid transport
HLV59_RS07755	COG0659	secondary active sulfate transmembrane transporter activity
HLV59_RS07775	COG3300	MHYT domain
HLV59_RS07775	COG5001	Diguanylate cyclase
HLV59_RS07790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLV59_RS07790	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLV59_RS07790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLV59_RS07795	COG1105	Belongs to the carbohydrate kinase PfkB family
HLV59_RS07800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLV59_RS07800	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLV59_RS07820	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HLV59_RS07830	COG0024	Methionine aminopeptidase
HLV59_RS07835	COG0583	DNA-binding transcription factor activity
HLV59_RS07845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLV59_RS07850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLV59_RS07855	COG0516	GMP reductase activity
HLV59_RS07855	COG0517	IMP dehydrogenase activity
HLV59_RS07880	COG0552	protein localization to endoplasmic reticulum
HLV59_RS07890	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HLV59_RS07900	COG4890	Cyd operon protein YbgT
HLV59_RS07905	COG1294	oxidase, subunit
HLV59_RS07920	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLV59_RS07930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLV59_RS07945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLV59_RS07950	COG0569	domain protein
HLV59_RS07955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLV59_RS07985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLV59_RS07990	COG0542	response to heat
HLV59_RS08000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLV59_RS08015	COG1902	pentaerythritol trinitrate reductase activity
HLV59_RS08015	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLV59_RS08055	COG0148	phosphopyruvate hydratase activity
HLV59_RS08060	COG2323	membrane
HLV59_RS08070	COG4773	Receptor
HLV59_RS08075	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HLV59_RS08085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLV59_RS08090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLV59_RS08095	COG0183	Belongs to the thiolase family
HLV59_RS08100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLV59_RS08105	COG0596	Alpha beta hydrolase
HLV59_RS08110	COG2271	Major facilitator Superfamily
HLV59_RS08115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLV59_RS08120	COG3485	protocatechuate 3,4-dioxygenase
HLV59_RS08125	COG3485	protocatechuate 3,4-dioxygenase
HLV59_RS08130	COG0710	3-dehydroquinate dehydratase activity
HLV59_RS08135	COG3420	alginic acid biosynthetic process
HLV59_RS08140	COG3659	wide pore channel activity
HLV59_RS08145	COG4993	Dehydrogenase
HLV59_RS08155	COG2391	methyltransferase activity
HLV59_RS08170	COG1414	Transcriptional regulator
HLV59_RS08175	COG0583	DNA-binding transcription factor activity
HLV59_RS08180	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS08205	COG2814	Major facilitator Superfamily
HLV59_RS08215	COG0154	amidase activity
HLV59_RS08235	COG4638	Rieske (2fe-2S)
HLV59_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLV59_RS08265	COG3733	amine oxidase
HLV59_RS08280	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS08285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLV59_RS08290	COG0183	Belongs to the thiolase family
HLV59_RS08295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLV59_RS08300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLV59_RS08310	COG4829	muconolactone delta-isomerase
HLV59_RS08315	COG4948	Mandelate Racemase Muconate Lactonizing
HLV59_RS08320	COG0583	DNA-binding transcription factor activity
HLV59_RS08330	COG2186	Transcriptional regulator
HLV59_RS08350	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS08355	COG1309	transcriptional regulator
HLV59_RS08360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLV59_RS08390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLV59_RS08395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLV59_RS08400	COG0745	RESPONSE REGULATOR receiver
HLV59_RS08405	COG2205	protein histidine kinase activity
HLV59_RS08435	COG2072	flavoprotein involved in K transport
HLV59_RS08440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLV59_RS08475	COG1946	Acyl-CoA thioesterase
HLV59_RS08480	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS08485	COG0583	DNA-binding transcription factor activity
HLV59_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08525	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS08530	COG0183	Belongs to the thiolase family
HLV59_RS08540	COG2271	Major facilitator Superfamily
HLV59_RS08545	COG0251	oxidation-reduction process
HLV59_RS08555	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS08575	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS08580	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08585	COG3829	transcription factor binding
HLV59_RS08605	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08610	COG1414	Transcriptional regulator
HLV59_RS08630	COG3659	wide pore channel activity
HLV59_RS08635	COG1309	transcriptional regulator
HLV59_RS08655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLV59_RS08665	COG1053	succinate dehydrogenase
HLV59_RS08670	COG1053	succinate dehydrogenase
HLV59_RS08680	COG1846	Transcriptional regulator
HLV59_RS08685	COG1024	Enoyl-CoA hydratase
HLV59_RS08690	COG2814	Major facilitator Superfamily
HLV59_RS08710	COG0644	oxidoreductase
HLV59_RS08710	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HLV59_RS08720	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS08725	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS08735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLV59_RS08745	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS08755	COG3971	2-oxopent-4-enoate hydratase activity
HLV59_RS08760	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HLV59_RS08780	COG0583	DNA-binding transcription factor activity
HLV59_RS08785	COG4638	Rieske (2fe-2S)
HLV59_RS08790	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLV59_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08805	COG3384	dioxygenase
HLV59_RS08810	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLV59_RS08815	COG2814	Major facilitator Superfamily
HLV59_RS08820	COG2814	Major facilitator Superfamily
HLV59_RS08825	COG0583	DNA-binding transcription factor activity
HLV59_RS08845	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLV59_RS08845	COG1902	pentaerythritol trinitrate reductase activity
HLV59_RS08890	COG1309	transcriptional regulator
HLV59_RS08895	COG4221	oxidoreductase activity
HLV59_RS08895	COG0604	alcohol dehydrogenase
HLV59_RS08895	COG3321	synthase
HLV59_RS08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLV59_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS08910	COG1733	regulation of RNA biosynthetic process
HLV59_RS08915	COG0702	epimerase
HLV59_RS08930	COG4689	acetoacetate decarboxylase
HLV59_RS08940	COG1902	pentaerythritol trinitrate reductase activity
HLV59_RS09060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLV59_RS09075	COG2271	Major facilitator Superfamily
HLV59_RS09080	COG1566	PFAM secretion protein HlyD family protein
HLV59_RS09095	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS09100	COG0129	dihydroxy-acid dehydratase activity
HLV59_RS09110	COG0583	DNA-binding transcription factor activity
HLV59_RS09115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLV59_RS09125	COG2084	Dehydrogenase
HLV59_RS09130	COG2207	Transcriptional regulator
HLV59_RS09135	COG1064	alcohol dehydrogenase
HLV59_RS09140	COG1309	transcriptional regulator
HLV59_RS09170	COG1120	ATPase activity
HLV59_RS09185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLV59_RS09290	COG1073	alpha beta
HLV59_RS09310	COG0747	negative chemotaxis
HLV59_RS09335	COG3539	Fimbrial protein
HLV59_RS09360	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HLV59_RS09390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLV59_RS09455	COG3433	isochorismatase activity
HLV59_RS09455	COG1535	isochorismatase
HLV59_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS09475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HLV59_RS09480	COG4149	molybdate abc transporter
HLV59_RS09485	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLV59_RS09495	COG4638	Rieske (2fe-2S)
HLV59_RS09500	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLV59_RS09505	COG0543	2 iron, 2 sulfur cluster binding
HLV59_RS09505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLV59_RS09520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLV59_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS09550	COG2207	Transcriptional regulator
HLV59_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS09560	COG2610	gluconate transmembrane transporter activity
HLV59_RS09580	COG0583	DNA-binding transcription factor activity
HLV59_RS09595	COG2031	fatty acid transporter
HLV59_RS09600	COG0183	Belongs to the thiolase family
HLV59_RS09605	COG0583	DNA-binding transcription factor activity
HLV59_RS09610	COG0583	DNA-binding transcription factor activity
HLV59_RS09625	COG1027	Aspartate ammonia-lyase
HLV59_RS09635	COG0477	Major facilitator Superfamily
HLV59_RS09660	COG4521	taurine ABC transporter
HLV59_RS09675	COG2188	Transcriptional regulator
HLV59_RS09690	COG1733	regulation of RNA biosynthetic process
HLV59_RS09695	COG3708	Transcriptional regulator
HLV59_RS09695	COG2207	Transcriptional regulator
HLV59_RS09710	COG0730	response to heat
HLV59_RS09720	COG3453	Protein conserved in bacteria
HLV59_RS09720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLV59_RS09730	COG3781	membrane
HLV59_RS09735	COG1063	alcohol dehydrogenase
HLV59_RS09745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLV59_RS09750	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLV59_RS09755	COG0022	dehydrogenase e1 component
HLV59_RS09760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLV59_RS09765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLV59_RS09780	COG3706	GGDEF domain
HLV59_RS09800	COG0133	tryptophan synthase activity
HLV59_RS09810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLV59_RS09840	COG0583	DNA-binding transcription factor activity
HLV59_RS09845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLV59_RS09855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLV59_RS09910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLV59_RS09915	COG4773	Receptor
HLV59_RS09935	COG0730	response to heat
HLV59_RS09940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLV59_RS09960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLV59_RS09975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLV59_RS09980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLV59_RS09995	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS10000	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS10005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLV59_RS10010	COG2207	Transcriptional regulator
HLV59_RS10015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLV59_RS10020	COG0776	regulation of translation
HLV59_RS10045	COG0822	iron-sulfur transferase activity
HLV59_RS10050	COG0316	Belongs to the HesB IscA family
HLV59_RS10080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLV59_RS10100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLV59_RS10105	COG0702	epimerase
HLV59_RS10145	COG0601	transmembrane transport
HLV59_RS10150	COG0339	signal peptide processing
HLV59_RS10155	COG4166	transmembrane transport
HLV59_RS10195	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLV59_RS10200	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLV59_RS10215	COG2431	L-lysine efflux transmembrane transporter activity
HLV59_RS10230	COG0776	regulation of translation
HLV59_RS10295	COG0084	hydrolase, TatD family'
HLV59_RS10315	COG1663	tetraacyldisaccharide 4'-kinase activity
HLV59_RS10320	COG1132	(ABC) transporter
HLV59_RS10330	COG0811	peptide transport
HLV59_RS10335	COG1475	DNA binding
HLV59_RS10340	COG1192	Involved in chromosome partitioning
HLV59_RS10350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLV59_RS10355	COG3178	'Phosphotransferase
HLV59_RS10365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLV59_RS10390	COG0424	maF-like protein
HLV59_RS10395	COG2850	peptidyl-arginine hydroxylation
HLV59_RS10405	COG0640	Transcriptional regulator
HLV59_RS10415	COG3619	membrane
HLV59_RS10420	COG3122	Protein conserved in bacteria
HLV59_RS10445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLV59_RS10450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLV59_RS10460	COG0506	proline dehydrogenase activity
HLV59_RS10460	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLV59_RS10460	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLV59_RS10465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLV59_RS10480	COG3698	Phosphodiester glycosidase
HLV59_RS10490	COG2353	YceI-like domain
HLV59_RS10500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLV59_RS10530	COG1247	-acetyltransferase
HLV59_RS10545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLV59_RS10545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLV59_RS10570	COG3539	Fimbrial protein
HLV59_RS10575	COG3121	Chaperone
HLV59_RS10605	COG0583	DNA-binding transcription factor activity
HLV59_RS10610	COG0697	spore germination
HLV59_RS10620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLV59_RS10630	COG0583	DNA-binding transcription factor activity
HLV59_RS10645	COG1309	transcriptional regulator
HLV59_RS10660	COG1522	sequence-specific DNA binding
HLV59_RS10670	COG1126	abc transporter atp-binding protein
HLV59_RS10675	COG0765	amino acid transport
HLV59_RS10680	COG0765	amino acid transport
HLV59_RS10710	COG1464	Belongs to the NlpA lipoprotein family
HLV59_RS10720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLV59_RS10725	COG2011	ABC-type metal ion transport system permease component
HLV59_RS10730	COG0012	GTP binding
HLV59_RS10750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLV59_RS10785	COG1917	Cupin 2, conserved barrel domain protein
HLV59_RS10785	COG2207	Transcriptional regulator
HLV59_RS10790	COG0386	Belongs to the glutathione peroxidase family
HLV59_RS10800	COG0436	Aminotransferase
HLV59_RS10805	COG1301	dicarboxylic acid transport
HLV59_RS10840	COG3634	alkyl hydroperoxide reductase activity
HLV59_RS10855	COG0583	DNA-binding transcription factor activity
HLV59_RS10860	COG0431	NADPH-dependent FMN reductase
HLV59_RS10865	COG0798	PFAM Bile acid sodium symporter
HLV59_RS10875	COG0640	Transcriptional regulator
HLV59_RS10890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLV59_RS10900	COG0583	DNA-binding transcription factor activity
HLV59_RS10910	COG1953	Uracil, thiamine, allantoin
HLV59_RS10920	COG2175	clavaminate synthase activity
HLV59_RS10925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLV59_RS10930	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HLV59_RS10935	COG4521	taurine ABC transporter
HLV59_RS10945	COG0477	Major facilitator Superfamily
HLV59_RS10965	COG1271	oxidase subunit
HLV59_RS10970	COG1294	oxidase, subunit
HLV59_RS10980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLV59_RS11000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLV59_RS11020	COG3052	prosthetic group binding
HLV59_RS11025	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HLV59_RS11050	COG2814	Major facilitator Superfamily
HLV59_RS11070	COG1346	cytolysis
HLV59_RS11080	COG0583	DNA-binding transcription factor activity
HLV59_RS11085	COG0625	glutathione transferase activity
HLV59_RS11090	COG0625	glutathione transferase activity
HLV59_RS11095	COG0583	DNA-binding transcription factor activity
HLV59_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS11110	COG1045	serine acetyltransferase
HLV59_RS11115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLV59_RS11120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLV59_RS11125	COG1280	lysine exporter protein (LysE YggA)
HLV59_RS11135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLV59_RS11140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLV59_RS11150	COG0765	amino acid transport
HLV59_RS11155	COG0765	amino acid transport
HLV59_RS11175	COG0784	Response regulator, receiver
HLV59_RS11175	COG2205	protein histidine kinase activity
HLV59_RS11195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLV59_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS11260	COG0583	DNA-binding transcription factor activity
HLV59_RS11270	COG2814	Major facilitator Superfamily
HLV59_RS11280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLV59_RS11285	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS11290	COG1309	transcriptional regulator
HLV59_RS11295	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS11300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLV59_RS11305	COG1024	Enoyl-CoA hydratase
HLV59_RS11310	COG4770	biotin carboxylase activity
HLV59_RS11320	COG0583	DNA-binding transcription factor activity
HLV59_RS11335	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS11345	COG2814	Major facilitator Superfamily
HLV59_RS11355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLV59_RS11360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLV59_RS11365	COG2814	Major facilitator Superfamily
HLV59_RS11370	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS11375	COG1024	Enoyl-CoA hydratase
HLV59_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS11385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLV59_RS11390	COG0183	Belongs to the thiolase family
HLV59_RS11400	COG2814	Major facilitator Superfamily
HLV59_RS11410	COG1024	Enoyl-CoA hydratase
HLV59_RS11425	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS11430	COG2814	Major facilitator Superfamily
HLV59_RS11435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLV59_RS11440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLV59_RS11455	COG3842	ATPase activity
HLV59_RS11460	COG1840	ABC-type Fe3 transport system, periplasmic component
HLV59_RS11475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLV59_RS11480	COG1414	Transcriptional regulator
HLV59_RS11485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLV59_RS11490	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS11500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLV59_RS11510	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS11515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLV59_RS11520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLV59_RS11525	COG2267	carboxylic ester hydrolase activity
HLV59_RS11565	COG1278	Cold shock
HLV59_RS11595	COG1309	transcriptional regulator
HLV59_RS11600	COG1309	transcriptional regulator
HLV59_RS11615	COG4221	oxidoreductase activity
HLV59_RS11620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLV59_RS11640	COG0300	oxidoreductase activity
HLV59_RS11655	COG0534	Mate efflux family protein
HLV59_RS11660	COG1309	transcriptional regulator
HLV59_RS11680	COG0406	alpha-ribazole phosphatase activity
HLV59_RS11695	COG2050	protein possibly involved in aromatic compounds catabolism
HLV59_RS11705	COG3327	negative regulation of DNA-templated transcription, initiation
HLV59_RS11710	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HLV59_RS11715	COG0183	Belongs to the thiolase family
HLV59_RS11720	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLV59_RS11725	COG1024	Enoyl-CoA hydratase
HLV59_RS11730	COG1024	Enoyl-CoA hydratase
HLV59_RS11735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLV59_RS11740	COG2151	metal-sulfur cluster biosynthetic enzyme
HLV59_RS11745	COG3396	Phenylacetate-CoA oxygenase
HLV59_RS11750	COG3460	Phenylacetate-CoA oxygenase
HLV59_RS11755	COG3396	Phenylacetate-CoA oxygenase
HLV59_RS11760	COG2030	dehydratase
HLV59_RS11760	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS11765	COG1760	l-serine dehydratase
HLV59_RS11770	COG0697	spore germination
HLV59_RS11780	COG0789	Transcriptional regulator
HLV59_RS11790	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLV59_RS11795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLV59_RS11810	COG2807	transmembrane transport
HLV59_RS11815	COG0590	tRNA wobble adenosine to inosine editing
HLV59_RS11965	COG3209	COG3209 Rhs family protein
HLV59_RS11985	COG1116	anion transmembrane transporter activity
HLV59_RS12000	COG0864	Transcriptional regulator
HLV59_RS12010	COG1733	regulation of RNA biosynthetic process
HLV59_RS12015	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLV59_RS12020	COG0439	Biotin carboxylase
HLV59_RS12035	COG1063	alcohol dehydrogenase
HLV59_RS12040	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLV59_RS12100	COG0038	chloride channel
HLV59_RS12105	COG4770	biotin carboxylase activity
HLV59_RS12125	COG1914	H( )-stimulated, divalent metal cation uptake system
HLV59_RS12140	COG1595	DNA-templated transcription, initiation
HLV59_RS12150	COG3220	belongs to the UPF0276 family
HLV59_RS12185	COG0598	Magnesium transport protein CorA
HLV59_RS12220	COG1234	tRNA 3'-trailer cleavage
HLV59_RS12225	COG1309	transcriptional regulator
HLV59_RS12255	COG1595	DNA-templated transcription, initiation
HLV59_RS12260	COG3712	iron ion homeostasis
HLV59_RS12285	COG0402	S-adenosylhomocysteine deaminase activity
HLV59_RS12315	COG3038	cytochrome b561
HLV59_RS12320	COG0753	catalase activity
HLV59_RS12325	COG1733	regulation of RNA biosynthetic process
HLV59_RS12355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HLV59_RS12365	COG4122	O-methyltransferase activity
HLV59_RS12375	COG0110	maltose O-acetyltransferase activity
HLV59_RS12395	COG1538	Outer membrane efflux protein
HLV59_RS12400	COG1137	ATPase activity
HLV59_RS12405	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HLV59_RS12415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HLV59_RS12455	COG2814	Major facilitator Superfamily
HLV59_RS12465	COG0668	transmembrane transport
HLV59_RS12510	COG1309	transcriptional regulator
HLV59_RS12540	COG2226	methyltransferase
HLV59_RS12565	COG1278	Cold shock
HLV59_RS12570	COG1560	Kdo2-lipid A biosynthetic process
HLV59_RS12575	COG1280	lysine exporter protein (LysE YggA)
HLV59_RS12610	COG1570	exodeoxyribonuclease VII activity
HLV59_RS12690	COG2871	sodium ion transport
HLV59_RS12700	COG0583	DNA-binding transcription factor activity
HLV59_RS12710	COG4638	Rieske (2fe-2S)
HLV59_RS12715	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLV59_RS12720	COG0543	2 iron, 2 sulfur cluster binding
HLV59_RS12720	COG0633	Ferredoxin
HLV59_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS12730	COG3135	benzoate transporter
HLV59_RS12735	COG2814	Major facilitator Superfamily
HLV59_RS12750	COG1643	Atp-dependent helicase
HLV59_RS12775	COG3634	alkyl hydroperoxide reductase activity
HLV59_RS12795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLV59_RS12810	COG0625	glutathione transferase activity
HLV59_RS12820	COG2885	chlorophyll binding
HLV59_RS12850	COG1546	Belongs to the CinA family
HLV59_RS12850	COG1058	Belongs to the CinA family
HLV59_RS12855	COG0542	response to heat
HLV59_RS12870	COG1765	OsmC-like protein
HLV59_RS12885	COG0667	Aldo Keto reductase
HLV59_RS12900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLV59_RS12915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLV59_RS12925	COG0527	aspartate kinase activity
HLV59_RS12935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLV59_RS12945	COG3038	cytochrome b561
HLV59_RS12950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLV59_RS12955	COG2252	PERMEase
HLV59_RS12965	COG1741	Belongs to the pirin family
HLV59_RS12970	COG1309	transcriptional regulator
HLV59_RS12985	COG2072	flavoprotein involved in K transport
HLV59_RS12990	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLV59_RS12995	COG0583	DNA-binding transcription factor activity
HLV59_RS13010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLV59_RS13040	COG1944	ATP diphosphatase activity
HLV59_RS13060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLV59_RS13075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLV59_RS13090	COG2814	Major facilitator Superfamily
HLV59_RS13095	COG1024	Enoyl-CoA hydratase
HLV59_RS13100	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS13110	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS13135	COG2186	Transcriptional regulator
HLV59_RS13140	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS13150	COG4948	Mandelate Racemase Muconate Lactonizing
HLV59_RS13155	COG2271	Major facilitator Superfamily
HLV59_RS13160	COG2721	sulfolactate sulfo-lyase activity
HLV59_RS13165	COG0697	spore germination
HLV59_RS13195	COG1113	amino acid transport
HLV59_RS13215	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS13235	COG0531	amino acid
HLV59_RS13245	COG1113	amino acid transport
HLV59_RS13290	COG1902	pentaerythritol trinitrate reductase activity
HLV59_RS13290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLV59_RS13300	COG4251	negative regulation of phosphorylation
HLV59_RS13300	COG2203	Gaf domain
HLV59_RS13300	COG3706	GGDEF domain
HLV59_RS13300	COG5001	Diguanylate cyclase
HLV59_RS13310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLV59_RS13330	COG4172	Belongs to the ABC transporter superfamily
HLV59_RS13335	COG4239	(ABC) transporter, permease
HLV59_RS13340	COG4174	ABC transporter (Permease)
HLV59_RS13345	COG4166	transmembrane transport
HLV59_RS13350	COG1388	LysM domain
HLV59_RS13350	COG0741	lytic transglycosylase activity
HLV59_RS13395	COG0583	DNA-binding transcription factor activity
HLV59_RS13400	COG1279	arginine transmembrane transporter activity
HLV59_RS13420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLV59_RS13425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLV59_RS13430	COG0006	proline dipeptidase activity
HLV59_RS13470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLV59_RS13485	COG3384	dioxygenase
HLV59_RS13495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLV59_RS13500	COG2878	Part of a membrane complex involved in electron transport
HLV59_RS13505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLV59_RS13530	COG0768	penicillin binding
HLV59_RS13535	COG0742	ribosomal rna small subunit methyltransferase
HLV59_RS13550	COG0830	nickel cation binding
HLV59_RS13560	COG0804	urea catabolic process
HLV59_RS13585	COG3015	lipoprotein NlpE involved in copper resistance
HLV59_RS13600	COG1253	flavin adenine dinucleotide binding
HLV59_RS13605	COG2851	Citrate transporter
HLV59_RS13660	COG1773	rubredoxin
HLV59_RS13665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLV59_RS13670	COG2267	carboxylic ester hydrolase activity
HLV59_RS13675	COG0583	DNA-binding transcription factor activity
HLV59_RS13705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HLV59_RS13710	COG4181	ATPase activity
HLV59_RS13735	COG4771	TonB-dependent receptor
HLV59_RS13755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLV59_RS13775	COG0306	phosphate transporter
HLV59_RS13785	COG3958	Transketolase
HLV59_RS13790	COG3959	Transketolase, thiamine diphosphate binding domain
HLV59_RS13795	COG2271	Major facilitator Superfamily
HLV59_RS13800	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS13805	COG0583	DNA-binding transcription factor activity
HLV59_RS13820	COG2223	nitrite transmembrane transporter activity
HLV59_RS13825	COG2207	Transcriptional regulator
HLV59_RS13830	COG2066	Belongs to the glutaminase family
HLV59_RS13835	COG0242	peptide deformylase activity
HLV59_RS13840	COG0477	Major facilitator Superfamily
HLV59_RS13850	COG0028	Belongs to the TPP enzyme family
HLV59_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS13870	COG2267	carboxylic ester hydrolase activity
HLV59_RS13880	COG2271	Major facilitator Superfamily
HLV59_RS13915	COG1414	Transcriptional regulator
HLV59_RS13940	COG1215	transferase activity, transferring glycosyl groups
HLV59_RS13945	COG1649	PFAM Uncharacterised BCR, COG1649
HLV59_RS13945	COG0726	polysaccharide deacetylase
HLV59_RS13955	COG4681	YaeQ
HLV59_RS13965	COG0523	cobalamin synthesis protein
HLV59_RS13975	COG1607	acyl-coa hydrolase
HLV59_RS13985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLV59_RS13990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLV59_RS13995	COG1309	transcriptional regulator
HLV59_RS14020	COG2040	homocysteine
HLV59_RS14025	COG0531	amino acid
HLV59_RS14080	COG1595	DNA-templated transcription, initiation
HLV59_RS14090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLV59_RS14095	COG0477	Major facilitator Superfamily
HLV59_RS14125	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLV59_RS14135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLV59_RS14145	COG0405	Gamma-glutamyltransferase
HLV59_RS14150	COG2814	Major facilitator Superfamily
HLV59_RS14160	COG2050	protein possibly involved in aromatic compounds catabolism
HLV59_RS14175	COG1090	epimerase
HLV59_RS14195	COG0420	3'-5' exonuclease activity
HLV59_RS14220	COG0735	belongs to the Fur family
HLV59_RS14225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLV59_RS14230	COG2914	Belongs to the UPF0125 (RnfH) family
HLV59_RS14245	COG0121	glutamine amidotransferase
HLV59_RS14260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLV59_RS14270	COG0210	DNA helicase
HLV59_RS14275	COG2885	chlorophyll binding
HLV59_RS14280	COG0204	Acyl-transferase
HLV59_RS14295	COG2894	cell division
HLV59_RS14310	COG1280	lysine exporter protein (LysE YggA)
HLV59_RS14315	COG1674	ftsk spoiiie
HLV59_RS14320	COG0492	ferredoxin-NADP+ reductase activity
HLV59_RS14325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HLV59_RS14335	COG0456	acetyltransferase
HLV59_RS14350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLV59_RS14355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLV59_RS14365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLV59_RS14390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLV59_RS14390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLV59_RS14410	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS14415	COG4638	Rieske (2fe-2S)
HLV59_RS14430	COG0473	3-isopropylmalate dehydrogenase activity
HLV59_RS14435	COG0583	DNA-binding transcription factor activity
HLV59_RS14455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLV59_RS14490	COG0358	DNA primase activity
HLV59_RS14505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HLV59_RS14535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLV59_RS14565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLV59_RS14575	COG0351	phosphomethylpyrimidine kinase
HLV59_RS14575	COG0352	thiamine-phosphate diphosphorylase activity
HLV59_RS14575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLV59_RS14580	COG1652	LysM domain
HLV59_RS14605	COG1399	metal-binding, possibly nucleic acid-binding protein
HLV59_RS14610	COG3101	peptidyl-lysine hydroxylation
HLV59_RS14615	COG0009	L-threonylcarbamoyladenylate synthase
HLV59_RS14620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HLV59_RS14625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLV59_RS14640	COG4106	trans-aconitate 2-methyltransferase activity
HLV59_RS14655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLV59_RS14655	COG2226	methyltransferase
HLV59_RS14655	COG0596	Alpha beta hydrolase
HLV59_RS14665	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HLV59_RS14670	COG2223	nitrite transmembrane transporter activity
HLV59_RS14690	COG1196	nuclear chromosome segregation
HLV59_RS14700	COG0730	response to heat
HLV59_RS14715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLV59_RS14770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLV59_RS14775	COG0489	protein tyrosine kinase activity
HLV59_RS14785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLV59_RS14785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLV59_RS14820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HLV59_RS14825	COG2081	HI0933 family
HLV59_RS14835	COG0668	transmembrane transport
HLV59_RS14855	COG0583	DNA-binding transcription factor activity
HLV59_RS14860	COG1278	Cold shock
HLV59_RS14875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLV59_RS14880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLV59_RS14910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HLV59_RS14935	COG2199	diguanylate cyclase activity
HLV59_RS14945	COG2205	protein histidine kinase activity
HLV59_RS14950	COG0745	RESPONSE REGULATOR receiver
HLV59_RS14965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLV59_RS15005	COG0110	maltose O-acetyltransferase activity
HLV59_RS15010	COG0438	transferase activity, transferring glycosyl groups
HLV59_RS15045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLV59_RS15060	COG0583	DNA-binding transcription factor activity
HLV59_RS15080	COG1473	amidohydrolase
HLV59_RS15115	COG0583	DNA-binding transcription factor activity
HLV59_RS15130	COG0583	DNA-binding transcription factor activity
HLV59_RS15135	COG1053	succinate dehydrogenase
HLV59_RS15150	COG1309	transcriptional regulator
HLV59_RS15160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLV59_RS15165	COG2814	Major facilitator Superfamily
HLV59_RS15170	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS15175	COG0583	DNA-binding transcription factor activity
HLV59_RS15180	COG1063	alcohol dehydrogenase
HLV59_RS15210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HLV59_RS15215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLV59_RS15220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLV59_RS15240	COG2132	Multicopper oxidase
HLV59_RS15250	COG0561	phosphatase activity
HLV59_RS15255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLV59_RS15265	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLV59_RS15280	COG1214	PFAM Peptidase M22, glycoprotease
HLV59_RS15340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLV59_RS15345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLV59_RS15350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLV59_RS15410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLV59_RS15420	COG1846	Transcriptional regulator
HLV59_RS15425	COG1764	response to oxidative stress
HLV59_RS15465	COG0037	tRNA processing
HLV59_RS15475	COG0248	Ppx GppA phosphatase
HLV59_RS15505	COG0072	phenylalanine-tRNA ligase activity
HLV59_RS15530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLV59_RS15545	COG1238	metal cluster binding
HLV59_RS15550	COG0625	glutathione transferase activity
HLV59_RS15565	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS15570	COG3028	Belongs to the UPF0307 family
HLV59_RS15575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLV59_RS15595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLV59_RS15600	COG0617	tRNA 3'-terminal CCA addition
HLV59_RS15605	COG1555	photosystem II stabilization
HLV59_RS15610	COG3956	TIGRFAM MazG family protein
HLV59_RS15620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLV59_RS15640	COG2205	protein histidine kinase activity
HLV59_RS15640	COG0784	Response regulator, receiver
HLV59_RS15640	COG5002	protein histidine kinase activity
HLV59_RS15645	COG1024	Enoyl-CoA hydratase
HLV59_RS15650	COG2084	Dehydrogenase
HLV59_RS15655	COG3622	Belongs to the hyi family
HLV59_RS15665	COG4221	oxidoreductase activity
HLV59_RS15685	COG0697	spore germination
HLV59_RS15695	COG2814	Major facilitator Superfamily
HLV59_RS15700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLV59_RS15710	COG0583	DNA-binding transcription factor activity
HLV59_RS15720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLV59_RS15730	COG0084	hydrolase, TatD family'
HLV59_RS15745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLV59_RS15765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLV59_RS15770	COG0440	acetolactate synthase activity
HLV59_RS15775	COG0028	Belongs to the TPP enzyme family
HLV59_RS15795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLV59_RS15800	COG1136	(ABC) transporter
HLV59_RS15800	COG0577	efflux transmembrane transporter activity
HLV59_RS15820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLV59_RS15825	COG1162	GTPase activity
HLV59_RS15835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLV59_RS15855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLV59_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS15910	COG1216	Glycosyl transferase, family 2
HLV59_RS15915	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS15925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLV59_RS15950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLV59_RS15970	COG1426	Protein conserved in bacteria
HLV59_RS16005	COG0793	Belongs to the peptidase S41A family
HLV59_RS16020	COG2267	carboxylic ester hydrolase activity
HLV59_RS16030	COG1012	belongs to the aldehyde dehydrogenase family
HLV59_RS16035	COG3265	gluconokinase activity
HLV59_RS16060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLV59_RS16065	COG0857	belongs to the CobB CobQ family
HLV59_RS16065	COG0280	phosphate acetyltransferase
HLV59_RS16070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLV59_RS16070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLV59_RS16090	COG0740	serine-type endopeptidase activity
HLV59_RS16100	COG4774	siderophore transport
HLV59_RS16110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLV59_RS16120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLV59_RS16120	COG2813	Specifically methylates the guanine in position
HLV59_RS16220	COG0788	formyltetrahydrofolate deformylase activity
HLV59_RS16245	COG4651	solute:proton antiporter activity
HLV59_RS16245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLV59_RS16265	COG0724	RNA recognition motif
HLV59_RS16270	COG0210	DNA helicase
HLV59_RS16295	COG1733	regulation of RNA biosynthetic process
HLV59_RS16305	COG2900	Belongs to the SlyX family
HLV59_RS16320	COG1560	Kdo2-lipid A biosynthetic process
HLV59_RS16330	COG1301	dicarboxylic acid transport
HLV59_RS16385	COG0473	3-isopropylmalate dehydrogenase activity
HLV59_RS16410	COG0583	DNA-binding transcription factor activity
HLV59_RS16450	COG0583	DNA-binding transcription factor activity
HLV59_RS16460	COG0625	glutathione transferase activity
HLV59_RS16465	COG2378	regulation of single-species biofilm formation
HLV59_RS16470	COG0546	phosphoglycolate phosphatase activity
HLV59_RS16480	COG1530	ribonuclease E activity
HLV59_RS16485	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS16500	COG0583	DNA-binding transcription factor activity
HLV59_RS16505	COG4221	oxidoreductase activity
HLV59_RS16510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLV59_RS16520	COG0534	Mate efflux family protein
HLV59_RS16535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLV59_RS16560	COG0493	'glutamate synthase
HLV59_RS16570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HLV59_RS16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLV59_RS16590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLV59_RS16600	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HLV59_RS16600	COG0644	oxidoreductase
HLV59_RS16615	COG4535	Mg2 and Co2 transporter CorC
HLV59_RS16625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLV59_RS16625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLV59_RS16645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLV59_RS16655	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLV59_RS16665	COG0484	heat shock protein binding
HLV59_RS16670	COG0789	Transcriptional regulator
HLV59_RS16675	COG0598	Magnesium transport protein CorA
HLV59_RS16680	COG1185	polyribonucleotide nucleotidyltransferase activity
HLV59_RS16695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLV59_RS16700	COG1074	ATP-dependent DNA helicase activity
HLV59_RS16705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HLV59_RS16725	COG2226	methyltransferase
HLV59_RS16735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLV59_RS16745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLV59_RS16760	COG2111	Na H antiporter
HLV59_RS16760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLV59_RS16765	COG1006	Multisubunit Na H antiporter MnhC subunit
HLV59_RS16770	COG0651	ATP synthesis coupled electron transport
HLV59_RS16780	COG2212	antiporter activity
HLV59_RS16790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLV59_RS16800	COG0195	Participates in both transcription termination and antitermination
HLV59_RS16850	COG0237	dephospho-CoA kinase activity
HLV59_RS16860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLV59_RS16875	COG0497	DNA recombination
HLV59_RS16885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLV59_RS16920	COG2169	Transcriptional regulator
HLV59_RS16920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLV59_RS16925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLV59_RS16995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLV59_RS17010	COG0326	Molecular chaperone. Has ATPase activity
HLV59_RS17025	COG2056	Na+-H+ antiporter family
HLV59_RS17095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLV59_RS17125	COG0546	phosphoglycolate phosphatase activity
HLV59_RS17130	COG1716	ATPase activity
HLV59_RS17175	COG0181	hydroxymethylbilane synthase activity
HLV59_RS17185	COG3275	phosphorelay sensor kinase activity
HLV59_RS17205	COG1538	Outer membrane efflux protein
HLV59_RS17215	COG0697	spore germination
HLV59_RS17235	COG0494	nUDIX hydrolase
HLV59_RS17240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLV59_RS17245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLV59_RS17250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLV59_RS17255	COG0772	Belongs to the SEDS family
HLV59_RS17280	COG4974	Belongs to the 'phage' integrase family
HLV59_RS17285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLV59_RS17295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLV59_RS17305	COG2197	response regulator
HLV59_RS17320	COG0793	Belongs to the peptidase S41A family
HLV59_RS17325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLV59_RS17330	COG0795	lipopolysaccharide-transporting ATPase activity
HLV59_RS17335	COG0795	lipopolysaccharide-transporting ATPase activity
HLV59_RS17370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLV59_RS17370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLV59_RS17380	COG0004	ammonium transporteR
HLV59_RS17385	COG0347	Belongs to the P(II) protein family
HLV59_RS17395	COG0606	chelatase, subunit chli
HLV59_RS17400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLV59_RS17405	COG0235	Class ii aldolase
HLV59_RS17430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLV59_RS17445	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS17455	COG0477	Major facilitator Superfamily
HLV59_RS17460	COG2860	membrane
HLV59_RS17470	COG1253	flavin adenine dinucleotide binding
HLV59_RS17485	COG2814	Major facilitator Superfamily
HLV59_RS17495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLV59_RS17530	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLV59_RS17540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLV59_RS17575	COG1309	transcriptional regulator
HLV59_RS17610	COG0758	DNA mediated transformation
HLV59_RS17620	COG0697	spore germination
HLV59_RS17625	COG1309	transcriptional regulator
HLV59_RS17640	COG0386	Belongs to the glutathione peroxidase family
HLV59_RS17660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLV59_RS17670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLV59_RS17710	COG1121	(ABC) transporter
HLV59_RS17715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLV59_RS17720	COG1280	lysine exporter protein (LysE YggA)
HLV59_RS17725	COG2837	iron assimilation
HLV59_RS17730	COG0281	malic enzyme
HLV59_RS17760	COG0519	Catalyzes the synthesis of GMP from XMP
HLV59_RS17760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLV59_RS17765	COG4399	Belongs to the UPF0754 family
HLV59_RS17770	COG2259	Doxx family
HLV59_RS17775	COG0586	Pfam SNARE associated Golgi protein
HLV59_RS17790	COG1192	Involved in chromosome partitioning
HLV59_RS17800	COG0271	Belongs to the BolA IbaG family
HLV59_RS17840	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HLV59_RS17840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLV59_RS17840	COG3321	synthase
HLV59_RS17840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLV59_RS17845	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS17850	COG0318	PFAM AMP-dependent synthetase and ligase
HLV59_RS17855	COG2197	response regulator
HLV59_RS17865	COG3916	Acyl-homoserine-lactone synthase
HLV59_RS17870	COG0477	Major facilitator Superfamily
HLV59_RS17875	COG1024	Enoyl-CoA hydratase
HLV59_RS17880	COG1024	Enoyl-CoA hydratase
HLV59_RS17885	COG1960	acyl-CoA dehydrogenase activity
HLV59_RS17890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLV59_RS17930	COG1113	amino acid transport
HLV59_RS17935	COG1113	amino acid transport
HLV59_RS17940	COG0251	oxidation-reduction process
HLV59_RS17980	COG0564	pseudouridine synthase activity
HLV59_RS18055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLV59_RS18070	COG1802	Transcriptional regulator
HLV59_RS18080	COG1448	Aminotransferase
HLV59_RS18085	COG0277	FAD linked oxidase domain protein
HLV59_RS18095	COG2186	Transcriptional regulator
HLV59_RS18105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLV59_RS18110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLV59_RS18125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLV59_RS18135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HLV59_RS18145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLV59_RS18160	COG1063	alcohol dehydrogenase
HLV59_RS18185	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLV59_RS18190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLV59_RS18195	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLV59_RS18225	COG0728	peptidoglycan biosynthetic process
HLV59_RS18230	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLV59_RS18285	COG0546	phosphoglycolate phosphatase activity
HLV59_RS18290	COG1028	Short-chain dehydrogenase reductase Sdr
HLV59_RS18305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLV59_RS18305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLV59_RS18310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLV59_RS18315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLV59_RS18320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLV59_RS18325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLV59_RS18330	COG1116	anion transmembrane transporter activity
HLV59_RS18335	COG1309	transcriptional regulator
HLV59_RS18340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLV59_RS18350	COG0196	riboflavin kinase activity
HLV59_RS18355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLV59_RS18365	COG1047	Peptidyl-prolyl cis-trans
HLV59_RS18405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLV59_RS18460	COG2951	lytic endotransglycosylase activity
HLV59_RS18465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLV59_RS18485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLV59_RS18495	COG0671	phosphoesterase, PA-phosphatase related
HLV59_RS18500	COG0861	Integral membrane protein TerC family
HLV59_RS18510	COG0754	glutathionylspermidine amidase activity
HLV59_RS18520	COG0402	S-adenosylhomocysteine deaminase activity
HLV59_RS18535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLV59_RS18540	COG1230	cation diffusion facilitator family transporter
HLV59_RS18555	COG0706	membrane insertase activity