locus-tag	class	description
H0S56_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S56_RS00010	COG0592	DNA-directed DNA polymerase activity
H0S56_RS00020	COG0187	DNA topoisomerase II activity
H0S56_RS00025	COG1063	alcohol dehydrogenase
H0S56_RS00030	COG0488	(ABC) transporter
H0S56_RS00085	COG0657	acetylesterase activity
H0S56_RS00095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S56_RS00125	COG2814	Major facilitator Superfamily
H0S56_RS00130	COG2814	Major facilitator Superfamily
H0S56_RS00140	COG0666	response to abiotic stimulus
H0S56_RS00145	COG0693	protein deglycase activity
H0S56_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_RS00160	COG0733	neurotransmitter:sodium symporter activity
H0S56_RS00170	COG0428	transporter
H0S56_RS00175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0S56_RS00190	COG0129	dihydroxy-acid dehydratase activity
H0S56_RS00205	COG2233	PERMEase
H0S56_RS00215	COG1309	transcriptional regulator
H0S56_RS00255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0S56_RS00265	COG1064	alcohol dehydrogenase
H0S56_RS00270	COG2818	Glycosylase
H0S56_RS00280	COG0739	heme binding
H0S56_RS00285	COG1194	a g-specific adenine glycosylase
H0S56_RS00320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S56_RS00325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S56_RS00345	COG0438	transferase activity, transferring glycosyl groups
H0S56_RS00350	COG0438	transferase activity, transferring glycosyl groups
H0S56_RS00355	COG0438	transferase activity, transferring glycosyl groups
H0S56_RS00365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S56_RS00375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0S56_RS00390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0S56_RS00405	COG2030	dehydratase
H0S56_RS00425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0S56_RS00450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S56_RS00455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S56_RS00470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S56_RS00480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S56_RS00485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S56_RS00495	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S56_RS00500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S56_RS00510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0S56_RS00530	COG0281	malic enzyme
H0S56_RS00585	COG1538	Outer membrane efflux protein
H0S56_RS00655	COG3756	Protein conserved in bacteria
H0S56_RS00690	COG0271	Belongs to the BolA IbaG family
H0S56_RS00700	COG1192	Involved in chromosome partitioning
H0S56_RS00715	COG0586	Pfam SNARE associated Golgi protein
H0S56_RS00720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S56_RS00720	COG0519	Catalyzes the synthesis of GMP from XMP
H0S56_RS00725	COG3706	GGDEF domain
H0S56_RS00730	COG3706	GGDEF domain
H0S56_RS00765	COG0534	Mate efflux family protein
H0S56_RS00770	COG0436	Aminotransferase
H0S56_RS00790	COG2837	iron assimilation
H0S56_RS00800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S56_RS00805	COG1121	(ABC) transporter
H0S56_RS00855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0S56_RS00870	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_RS00885	COG0386	Belongs to the glutathione peroxidase family
H0S56_RS00890	COG0697	spore germination
H0S56_RS00900	COG0758	DNA mediated transformation
H0S56_RS00950	COG2814	Major facilitator Superfamily
H0S56_RS00970	COG0477	Major facilitator Superfamily
H0S56_RS00975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S56_RS01010	COG1253	flavin adenine dinucleotide binding
H0S56_RS01020	COG2860	membrane
H0S56_RS01025	COG0477	Major facilitator Superfamily
H0S56_RS01035	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_RS01050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S56_RS01065	COG0606	chelatase, subunit chli
H0S56_RS01075	COG0347	Belongs to the P(II) protein family
H0S56_RS01080	COG0004	ammonium transporteR
H0S56_RS01090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S56_RS01090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S56_RS01105	COG0586	Pfam SNARE associated Golgi protein
H0S56_RS01125	COG0795	lipopolysaccharide-transporting ATPase activity
H0S56_RS01130	COG0795	lipopolysaccharide-transporting ATPase activity
H0S56_RS01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S56_RS01140	COG0793	Belongs to the peptidase S41A family
H0S56_RS01140	COG3409	Peptidoglycan-binding domain 1 protein
H0S56_RS01150	COG4191	Histidine kinase
H0S56_RS01155	COG2197	response regulator
H0S56_RS01160	COG1686	Belongs to the peptidase S11 family
H0S56_RS01165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S56_RS01175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S56_RS01180	COG4974	Belongs to the 'phage' integrase family
H0S56_RS01205	COG0772	Belongs to the SEDS family
H0S56_RS01215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S56_RS01220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S56_RS01225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S56_RS01230	COG0494	nUDIX hydrolase
H0S56_RS01245	COG1538	Outer membrane efflux protein
H0S56_RS01255	COG1132	(ABC) transporter
H0S56_RS01265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S56_RS01295	COG0497	DNA recombination
H0S56_RS01300	COG3123	guanosine phosphorylase activity
H0S56_RS01305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S56_RS01315	COG0237	dephospho-CoA kinase activity
H0S56_RS01370	COG0779	Required for maturation of 30S ribosomal subunits
H0S56_RS01375	COG0195	Participates in both transcription termination and antitermination
H0S56_RS01385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0S56_RS01390	COG1320	monovalent cation:proton antiporter activity
H0S56_RS01395	COG2212	antiporter activity
H0S56_RS01400	COG1863	multisubunit Na H antiporter MnhE subunit
H0S56_RS01405	COG0651	ATP synthesis coupled electron transport
H0S56_RS01410	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S56_RS01415	COG2111	Na H antiporter
H0S56_RS01415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S56_RS01430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S56_RS01435	COG4221	oxidoreductase activity
H0S56_RS01440	COG2873	o-acetylhomoserine
H0S56_RS01445	COG0488	(ABC) transporter
H0S56_RS01465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S56_RS01480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S56_RS01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S56_RS01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S56_RS01510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0S56_RS01515	COG2226	methyltransferase
H0S56_RS01520	COG3385	transposase activity
H0S56_RS01570	COG0070	glutamate synthase
H0S56_RS01570	COG0069	glutamate synthase activity
H0S56_RS01570	COG0067	glutamate synthase
H0S56_RS01575	COG0493	'glutamate synthase
H0S56_RS01580	COG1704	LemA family
H0S56_RS01600	COG3307	-O-antigen
H0S56_RS01610	COG3307	-O-antigen
H0S56_RS01635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S56_RS01640	COG1758	RNA polymerase activity
H0S56_RS01645	COG0194	GDP metabolic process
H0S56_RS01690	COG0228	four-way junction DNA binding
H0S56_RS01695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S56_RS01705	COG0335	large ribosomal subunit rRNA binding
H0S56_RS01715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H0S56_RS01725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H0S56_RS01730	COG5380	lipid catabolic process
H0S56_RS01735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S56_RS01755	COG5006	permease, DMT superfamily
H0S56_RS01760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S56_RS01765	COG0277	FAD linked oxidase domain protein
H0S56_RS01780	COG2814	Major facilitator Superfamily
H0S56_RS01785	COG1289	transmembrane transporter activity
H0S56_RS01795	COG0628	permease
H0S56_RS01815	COG2226	methyltransferase
H0S56_RS01830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0S56_RS01835	COG0254	rRNA binding
H0S56_RS01840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S56_RS01850	COG0534	Mate efflux family protein
H0S56_RS01860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S56_RS01870	COG1278	Cold shock
H0S56_RS01875	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS01890	COG0408	coproporphyrinogen oxidase activity
H0S56_RS01895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S56_RS01915	COG0513	Belongs to the DEAD box helicase family
H0S56_RS01920	COG1127	ABC transporter
H0S56_RS01925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S56_RS01930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S56_RS01945	COG0598	Magnesium transport protein CorA
H0S56_RS01955	COG0494	nUDIX hydrolase
H0S56_RS01960	COG1040	competence protein
H0S56_RS01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S56_RS01975	COG2937	Belongs to the GPAT DAPAT family
H0S56_RS01980	COG1946	Acyl-CoA thioesterase
H0S56_RS01985	COG1301	dicarboxylic acid transport
H0S56_RS01995	COG1959	2 iron, 2 sulfur cluster binding
H0S56_RS02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S56_RS02000	COG1017	nitric oxide dioxygenase activity
H0S56_RS02005	COG0433	COG0433 Predicted ATPase
H0S56_RS02010	COG0626	cystathionine gamma-synthase activity
H0S56_RS02030	COG0088	Forms part of the polypeptide exit tunnel
H0S56_RS02035	COG0089	rRNA binding
H0S56_RS02045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0S56_RS02095	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0S56_RS02100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0S56_RS02110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0S56_RS02135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0S56_RS02145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0S56_RS02150	COG0202	RNA polymerase activity
H0S56_RS02155	COG0203	ribosomal protein L17
H0S56_RS02160	COG2072	flavoprotein involved in K transport
H0S56_RS02170	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S56_RS02205	COG0697	spore germination
H0S56_RS02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S56_RS02220	COG0339	signal peptide processing
H0S56_RS02230	COG0557	exoribonuclease II activity
H0S56_RS02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S56_RS02295	COG1295	ribonuclease BN
H0S56_RS02350	COG1702	phosphate starvation-inducible protein PhoH
H0S56_RS02355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0S56_RS02360	COG0739	heme binding
H0S56_RS02360	COG0741	lytic transglycosylase activity
H0S56_RS02360	COG1196	nuclear chromosome segregation
H0S56_RS02400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S56_RS02405	COG1183	phosphatidylcholine synthase activity
H0S56_RS02440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S56_RS02470	COG1607	acyl-coa hydrolase
H0S56_RS02500	COG2350	Protein conserved in bacteria
H0S56_RS02515	COG3781	membrane
H0S56_RS02520	COG2003	Belongs to the UPF0758 family
H0S56_RS02525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S56_RS02535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S56_RS02590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0S56_RS02595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0S56_RS02605	COG2205	protein histidine kinase activity
H0S56_RS02610	COG0745	RESPONSE REGULATOR receiver
H0S56_RS02625	COG0174	glutamine synthetase
H0S56_RS02635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0S56_RS02645	COG0732	type I restriction modification DNA specificity domain
H0S56_RS02660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H0S56_RS02675	COG2814	Major facilitator Superfamily
H0S56_RS02700	COG3622	Belongs to the hyi family
H0S56_RS02705	COG2084	Dehydrogenase
H0S56_RS02720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S56_RS02735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S56_RS02745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0S56_RS02755	COG1862	Preprotein translocase
H0S56_RS02770	COG1704	LemA family
H0S56_RS02780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0S56_RS02830	COG0285	dihydrofolate synthase activity
H0S56_RS02845	COG0450	alkyl hydroperoxide reductase
H0S56_RS02850	COG0653	protein targeting
H0S56_RS02860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S56_RS02865	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S56_RS02920	COG2969	positive regulation of protein catabolic process
H0S56_RS02925	COG0625	glutathione transferase activity
H0S56_RS02930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S56_RS02935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S56_RS02940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0S56_RS02945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S56_RS02950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S56_RS02985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S56_RS02995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S56_RS03000	COG1408	metallophosphoesterase
H0S56_RS03010	COG0477	Major facilitator Superfamily
H0S56_RS03015	COG1272	protein, Hemolysin III
H0S56_RS03035	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_RS03035	COG1024	Enoyl-CoA hydratase
H0S56_RS03040	COG0183	Belongs to the thiolase family
H0S56_RS03045	COG2207	Transcriptional regulator
H0S56_RS03050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S56_RS03055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_RS03070	COG0183	Belongs to the thiolase family
H0S56_RS03090	COG0833	amino acid
H0S56_RS03100	COG2233	PERMEase
H0S56_RS03105	COG1217	gtp-binding protein TYPA
H0S56_RS03130	COG1902	pentaerythritol trinitrate reductase activity
H0S56_RS03150	COG0354	folic acid binding
H0S56_RS03155	COG2132	Multicopper oxidase
H0S56_RS03195	COG0564	pseudouridine synthase activity
H0S56_RS03215	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S56_RS03230	COG0628	permease
H0S56_RS03240	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_RS03240	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S56_RS03240	COG0351	phosphomethylpyrimidine kinase
H0S56_RS03255	COG3152	Membrane
H0S56_RS03270	COG4772	TonB-dependent receptor
H0S56_RS03275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S56_RS03280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S56_RS03280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0S56_RS03285	COG0745	RESPONSE REGULATOR receiver
H0S56_RS03290	COG2205	protein histidine kinase activity
H0S56_RS03305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S56_RS03325	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S56_RS03340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S56_RS03350	COG0713	ATP synthesis coupled electron transport
H0S56_RS03355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S56_RS03360	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S56_RS03385	COG1278	Cold shock
H0S56_RS03390	COG0583	DNA-binding transcription factor activity
H0S56_RS03430	COG0668	transmembrane transport
H0S56_RS03445	COG2081	HI0933 family
H0S56_RS03455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S56_RS03475	COG0004	ammonium transporteR
H0S56_RS03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S56_RS03495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S56_RS03495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S56_RS03515	COG0489	protein tyrosine kinase activity
H0S56_RS03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_RS03585	COG0840	transmembrane signaling receptor activity
H0S56_RS03590	COG2198	Histidine kinase
H0S56_RS03590	COG0784	Response regulator, receiver
H0S56_RS03590	COG0643	Histidine kinase
H0S56_RS03615	COG2832	Protein of unknown function (DUF454)
H0S56_RS03675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S56_RS03685	COG1289	transmembrane transporter activity
H0S56_RS03690	COG2814	Major facilitator Superfamily
H0S56_RS03700	COG0786	glutamate:sodium symporter activity
H0S56_RS03705	COG1115	amino acid carrier protein
H0S56_RS03710	COG2059	Chromate
H0S56_RS03715	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S56_RS03725	COG1607	acyl-coa hydrolase
H0S56_RS03735	COG2814	Major facilitator Superfamily
H0S56_RS03760	COG0523	cobalamin synthesis protein
H0S56_RS03765	COG4681	YaeQ
H0S56_RS03780	COG2203	Gaf domain
H0S56_RS03780	COG3706	GGDEF domain
H0S56_RS03780	COG4251	negative regulation of phosphorylation
H0S56_RS03780	COG5001	Diguanylate cyclase
H0S56_RS03810	COG0393	Putative heavy-metal-binding
H0S56_RS03815	COG0393	Putative heavy-metal-binding
H0S56_RS03830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_RS03835	COG0671	phosphoesterase, PA-phosphatase related
H0S56_RS03850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0S56_RS03860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S56_RS03870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0S56_RS03875	COG1648	precorrin-2 dehydrogenase activity
H0S56_RS03875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S56_RS03880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S56_RS03890	COG0531	amino acid
H0S56_RS03905	COG0321	lipoyl(octanoyl) transferase activity
H0S56_RS03940	COG0586	Pfam SNARE associated Golgi protein
H0S56_RS03965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S56_RS03990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0S56_RS03995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S56_RS04025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0S56_RS04035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0S56_RS04040	COG0358	DNA primase activity
H0S56_RS04050	COG0564	pseudouridine synthase activity
H0S56_RS04075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S56_RS04100	COG0251	oxidation-reduction process
H0S56_RS04105	COG1309	transcriptional regulator
H0S56_RS04115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0S56_RS04120	COG0505	Belongs to the CarA family
H0S56_RS04150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S56_RS04160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S56_RS04195	COG1253	flavin adenine dinucleotide binding
H0S56_RS04215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S56_RS04225	COG2239	Acts as a magnesium transporter
H0S56_RS04235	COG0501	Belongs to the peptidase M48B family
H0S56_RS04240	COG0739	heme binding
H0S56_RS04240	COG0741	lytic transglycosylase activity
H0S56_RS04240	COG1196	nuclear chromosome segregation
H0S56_RS04245	COG0037	tRNA processing
H0S56_RS04260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S56_RS04280	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H0S56_RS04295	COG1716	ATPase activity
H0S56_RS04295	COG5001	Diguanylate cyclase
H0S56_RS04300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S56_RS04305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0S56_RS04310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S56_RS04355	COG1115	amino acid carrier protein
H0S56_RS04360	COG1113	amino acid transport
H0S56_RS04370	COG0019	diaminopimelate decarboxylase activity
H0S56_RS04385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S56_RS04395	COG1522	sequence-specific DNA binding
H0S56_RS04400	COG1280	lysine exporter protein (LysE YggA)
H0S56_RS04440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_RS04460	COG1671	Belongs to the UPF0178 family
H0S56_RS04480	COG1136	(ABC) transporter
H0S56_RS04500	COG2267	carboxylic ester hydrolase activity
H0S56_RS04510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S56_RS04515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0S56_RS04520	COG0628	permease
H0S56_RS04555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S56_RS04575	COG0823	Involved in the tonB-independent uptake of proteins
H0S56_RS04595	COG0824	Thioesterase
H0S56_RS04600	COG1473	amidohydrolase
H0S56_RS04615	COG2255	four-way junction helicase activity
H0S56_RS04635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S56_RS04635	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S56_RS04655	COG0583	DNA-binding transcription factor activity
H0S56_RS04665	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H0S56_RS04680	COG0778	Nitroreductase
H0S56_RS04690	COG1056	cytidyltransferase-related domain
H0S56_RS04690	COG1051	belongs to the nudix hydrolase family
H0S56_RS04695	COG0583	DNA-binding transcription factor activity
H0S56_RS04705	COG2353	YceI-like domain
H0S56_RS04710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S56_RS04720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S56_RS04725	COG0602	queuosine metabolic process
H0S56_RS04745	COG0583	DNA-binding transcription factor activity
H0S56_RS04750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S56_RS04755	COG4208	sulfate ABC transporter
H0S56_RS04770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S56_RS04775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S56_RS04785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S56_RS04805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S56_RS04820	COG0681	Belongs to the peptidase S26 family
H0S56_RS04830	COG0571	ribonuclease III activity
H0S56_RS04835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S56_RS04845	COG1381	Involved in DNA repair and RecF pathway recombination
H0S56_RS04850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S56_RS04880	COG0436	Aminotransferase
H0S56_RS04890	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S56_RS04915	COG2951	lytic endotransglycosylase activity
H0S56_RS04930	COG0842	Transport permease protein
H0S56_RS04935	COG1131	(ABC) transporter
H0S56_RS04945	COG3706	GGDEF domain
H0S56_RS04980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S56_RS05000	COG3634	alkyl hydroperoxide reductase activity
H0S56_RS05005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S56_RS05010	COG0826	peptidase U32
H0S56_RS05040	COG1720	tRNA m6t6A37 methyltransferase activity
H0S56_RS05050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0S56_RS05065	COG0642	Histidine kinase
H0S56_RS05075	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_RS05085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S56_RS05090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S56_RS05095	COG3139	Protein of unknown function (DUF1315)
H0S56_RS05105	COG1301	dicarboxylic acid transport
H0S56_RS05115	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS05120	COG0693	protein deglycase activity
H0S56_RS05130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0S56_RS05135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S56_RS05160	COG2252	PERMEase
H0S56_RS05165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S56_RS05185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S56_RS05195	COG0527	aspartate kinase activity
H0S56_RS05200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0S56_RS05205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0S56_RS05235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S56_RS05255	COG1252	NADH dehydrogenase
H0S56_RS05260	COG1686	Belongs to the peptidase S11 family
H0S56_RS05280	COG2351	hydroxyisourate hydrolase activity
H0S56_RS05305	COG0436	Aminotransferase
H0S56_RS05310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S56_RS05315	COG0386	Belongs to the glutathione peroxidase family
H0S56_RS05325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H0S56_RS05345	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S56_RS05355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S56_RS05360	COG0012	GTP binding
H0S56_RS05390	COG0204	Acyl-transferase
H0S56_RS05420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S56_RS05420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S56_RS05425	COG1254	Belongs to the acylphosphatase family
H0S56_RS05455	COG3634	alkyl hydroperoxide reductase activity
H0S56_RS05480	COG1643	Atp-dependent helicase
H0S56_RS05500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S56_RS05535	COG0802	atpase or kinase
H0S56_RS05540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S56_RS05550	COG1923	regulation of RNA biosynthetic process
H0S56_RS05555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S56_RS05565	COG3178	'Phosphotransferase
H0S56_RS05570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S56_RS05580	COG1192	Involved in chromosome partitioning
H0S56_RS05585	COG1475	DNA binding
H0S56_RS05590	COG0811	peptide transport
H0S56_RS05600	COG1132	(ABC) transporter
H0S56_RS05605	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S56_RS05625	COG0084	hydrolase, TatD family'
H0S56_RS05630	COG1309	transcriptional regulator
H0S56_RS05660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0S56_RS05680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0S56_RS05690	COG0776	regulation of translation
H0S56_RS05710	COG2431	L-lysine efflux transmembrane transporter activity
H0S56_RS05725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S56_RS05730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S56_RS05750	COG1253	flavin adenine dinucleotide binding
H0S56_RS05770	COG0308	aminopeptidase N
H0S56_RS05780	COG0589	response to stress
H0S56_RS05785	COG0589	response to stress
H0S56_RS05800	COG3135	benzoate transporter
H0S56_RS05810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S56_RS05815	COG0583	DNA-binding transcription factor activity
H0S56_RS05830	COG0183	Belongs to the thiolase family
H0S56_RS05855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0S56_RS05860	COG0824	Thioesterase
H0S56_RS05865	COG1454	alcohol dehydrogenase
H0S56_RS05870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S56_RS05890	COG0069	glutamate synthase activity
H0S56_RS05900	COG2308	Evidence 4 Homologs of previously reported genes of
H0S56_RS05910	COG1305	Transglutaminase-like
H0S56_RS05925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S56_RS05930	COG0305	Participates in initiation and elongation during chromosome replication
H0S56_RS05945	COG0360	Binds together with S18 to 16S ribosomal RNA
H0S56_RS05955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S56_RS05960	COG1845	cytochrome c oxidase, subunit III
H0S56_RS05965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S56_RS05970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0S56_RS05995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S56_RS06010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0S56_RS06015	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S56_RS06035	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS06040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S56_RS06050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0S56_RS06085	COG0477	Major facilitator Superfamily
H0S56_RS06090	COG0729	surface antigen
H0S56_RS06130	COG1570	exodeoxyribonuclease VII activity
H0S56_RS06165	COG0786	glutamate:sodium symporter activity
H0S56_RS06205	COG3723	Recombinational DNA repair protein, rece pathway
H0S56_RS06290	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H0S56_RS06325	COG3728	DNA packaging
H0S56_RS06325	COG5484	DNA packaging
H0S56_RS06505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0S56_RS06540	COG0583	DNA-binding transcription factor activity
H0S56_RS06545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0S56_RS06560	COG1902	pentaerythritol trinitrate reductase activity
H0S56_RS06560	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S56_RS06590	COG0148	phosphopyruvate hydratase activity
H0S56_RS06605	COG3293	Transposase
H0S56_RS06610	COG0772	Belongs to the SEDS family
H0S56_RS06620	COG4890	Cyd operon protein YbgT
H0S56_RS06625	COG1294	oxidase, subunit
H0S56_RS06675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S56_RS06695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S56_RS06705	COG0133	tryptophan synthase activity
H0S56_RS06710	COG0517	IMP dehydrogenase activity
H0S56_RS06740	COG0612	Peptidase, M16
H0S56_RS06745	COG0552	protein localization to endoplasmic reticulum
H0S56_RS06805	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS06870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S56_RS06875	COG0730	response to heat
H0S56_RS06880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S56_RS06885	COG2207	Transcriptional regulator
H0S56_RS06890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S56_RS06895	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS06900	COG2169	Transcriptional regulator
H0S56_RS06920	COG1294	oxidase, subunit
H0S56_RS06930	COG1525	nuclease
H0S56_RS06985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S56_RS06990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S56_RS07000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S56_RS07005	COG2801	Transposase and inactivated derivatives
H0S56_RS07020	COG2814	Major facilitator Superfamily
H0S56_RS07025	COG0509	glycine decarboxylation via glycine cleavage system
H0S56_RS07035	COG1132	(ABC) transporter
H0S56_RS07040	COG0668	transmembrane transport
H0S56_RS07045	COG3122	Protein conserved in bacteria
H0S56_RS07055	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H0S56_RS07065	COG0640	Transcriptional regulator
H0S56_RS07070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S56_RS07080	COG0789	Transcriptional regulator
H0S56_RS07095	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS07100	COG0183	Belongs to the thiolase family
H0S56_RS07120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S56_RS07125	COG0183	Belongs to the thiolase family
H0S56_RS07130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S56_RS07135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S56_RS07140	COG3135	benzoate transporter
H0S56_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_RS07150	COG0633	Ferredoxin
H0S56_RS07150	COG0543	2 iron, 2 sulfur cluster binding
H0S56_RS07155	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S56_RS07160	COG4638	Rieske (2fe-2S)
H0S56_RS07170	COG4829	muconolactone delta-isomerase
H0S56_RS07175	COG4948	Mandelate Racemase Muconate Lactonizing
H0S56_RS07180	COG0583	DNA-binding transcription factor activity
H0S56_RS07185	COG2814	Major facilitator Superfamily
H0S56_RS07195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S56_RS07200	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_RS07205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S56_RS07205	COG1017	nitric oxide dioxygenase activity
H0S56_RS07220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S56_RS07240	COG0439	Biotin carboxylase
H0S56_RS07250	COG0864	Transcriptional regulator
H0S56_RS07260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S56_RS07285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S56_RS07290	COG3293	Transposase
H0S56_RS07295	COG1116	anion transmembrane transporter activity
H0S56_RS07295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S56_RS07305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_RS07310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_RS07315	COG0243	molybdopterin cofactor binding
H0S56_RS07325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S56_RS07335	COG0314	molybdopterin synthase activity
H0S56_RS07340	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S56_RS07340	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S56_RS07345	COG0303	'Molybdopterin
H0S56_RS07350	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S56_RS07355	COG4149	molybdate abc transporter
H0S56_RS07360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0S56_RS07365	COG2223	nitrite transmembrane transporter activity
H0S56_RS07370	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H0S56_RS07375	COG2116	formate transmembrane transporter activity
H0S56_RS07380	COG0515	serine threonine protein kinase
H0S56_RS07395	COG0583	DNA-binding transcription factor activity
H0S56_RS07410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S56_RS07415	COG1309	transcriptional regulator
H0S56_RS07435	COG1944	ATP diphosphatase activity
H0S56_RS07440	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S56_RS07440	COG0644	oxidoreductase
H0S56_RS07450	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS07455	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS07460	COG2814	Major facilitator Superfamily
H0S56_RS07465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S56_RS07470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S56_RS07475	COG5001	Diguanylate cyclase
H0S56_RS07480	COG2814	Major facilitator Superfamily
H0S56_RS07490	COG2814	Major facilitator Superfamily
H0S56_RS07500	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_RS07505	COG0183	Belongs to the thiolase family
H0S56_RS07515	COG0235	Class ii aldolase
H0S56_RS07520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S56_RS07525	COG1024	Enoyl-CoA hydratase
H0S56_RS07535	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS07550	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_RS07555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S56_RS07560	COG2814	Major facilitator Superfamily
H0S56_RS07595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S56_RS07600	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS07605	COG1024	Enoyl-CoA hydratase
H0S56_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_RS07635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S56_RS07640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S56_RS07645	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_RS07655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S56_RS07670	COG2194	sulfuric ester hydrolase activity
H0S56_RS07675	COG0745	RESPONSE REGULATOR receiver
H0S56_RS07680	COG0642	Histidine kinase
H0S56_RS07710	COG0596	Alpha beta hydrolase
H0S56_RS07745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S56_RS07780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S56_RS07795	COG0439	Biotin carboxylase
H0S56_RS07820	COG2814	Major facilitator Superfamily
H0S56_RS07825	COG0753	catalase activity
H0S56_RS07870	COG0372	Belongs to the citrate synthase family
H0S56_RS07900	COG0542	response to heat
H0S56_RS07905	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S56_RS07925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0S56_RS07930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S56_RS07935	COG0569	domain protein
H0S56_RS07940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S56_RS07960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S56_RS07970	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S56_RS07990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S56_RS07995	COG0776	regulation of translation
H0S56_RS08020	COG0822	iron-sulfur transferase activity
H0S56_RS08025	COG0316	Belongs to the HesB IscA family
H0S56_RS08055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S56_RS08065	COG1027	Aspartate ammonia-lyase
H0S56_RS08070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S56_RS08100	COG3781	membrane
H0S56_RS08130	COG0778	Nitroreductase
H0S56_RS08140	COG0697	spore germination
H0S56_RS08165	COG0424	maF-like protein
H0S56_RS08170	COG2850	peptidyl-arginine hydroxylation
H0S56_RS08195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S56_RS08200	COG0702	epimerase
H0S56_RS08205	COG0268	Binds directly to 16S ribosomal RNA
H0S56_RS08220	COG1011	Hydrolase
H0S56_RS08225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S56_RS08230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0S56_RS08235	COG2137	regulation of response to DNA damage stimulus
H0S56_RS08250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S56_RS08255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0S56_RS08270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S56_RS08285	COG0575	Belongs to the CDS family
H0S56_RS08290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S56_RS08310	COG3852	Histidine kinase
H0S56_RS08325	COG2814	Major facilitator Superfamily
H0S56_RS08360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S56_RS08365	COG0138	bifunctional purine biosynthesis protein purh
H0S56_RS08385	COG1464	Belongs to the NlpA lipoprotein family
H0S56_RS08390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S56_RS08395	COG2011	ABC-type metal ion transport system permease component
H0S56_RS08430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S56_RS08440	COG4122	O-methyltransferase activity
H0S56_RS08470	COG1538	Outer membrane efflux protein
H0S56_RS08475	COG1137	ATPase activity
H0S56_RS08480	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S56_RS08490	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S56_RS08495	COG0517	IMP dehydrogenase activity
H0S56_RS08495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S56_RS08525	COG0625	glutathione transferase activity
H0S56_RS08530	COG0505	Belongs to the CarA family
H0S56_RS08555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S56_RS08565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0S56_RS08575	COG2391	methyltransferase activity
H0S56_RS08630	COG1309	transcriptional regulator
H0S56_RS08680	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_RS08695	COG3025	triphosphatase activity
H0S56_RS08715	COG0612	Peptidase, M16
H0S56_RS08810	COG2199	diguanylate cyclase activity
H0S56_RS08810	COG2203	Gaf domain
H0S56_RS08840	COG4783	chaperone-mediated protein folding
H0S56_RS08855	COG0501	Belongs to the peptidase M48B family
H0S56_RS08870	COG0167	dihydroorotate dehydrogenase activity
H0S56_RS08895	COG0778	Nitroreductase
H0S56_RS08905	COG0513	Belongs to the DEAD box helicase family
H0S56_RS08910	COG1278	Cold shock
H0S56_RS08925	COG2363	Small membrane protein
H0S56_RS08940	COG0625	glutathione transferase activity
H0S56_RS08945	COG0659	secondary active sulfate transmembrane transporter activity
H0S56_RS08950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S56_RS08970	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_RS08975	COG1309	transcriptional regulator
H0S56_RS08980	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS08985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S56_RS08990	COG1024	Enoyl-CoA hydratase
H0S56_RS08995	COG4770	biotin carboxylase activity
H0S56_RS09010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S56_RS09015	COG2031	fatty acid transporter
H0S56_RS09030	COG0540	Belongs to the ATCase OTCase family
H0S56_RS09055	COG0667	Aldo Keto reductase
H0S56_RS09065	COG1765	OsmC-like protein
H0S56_RS09070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S56_RS09105	COG0640	Transcriptional regulator
H0S56_RS09115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0S56_RS09120	COG4232	protein-disulfide reductase activity
H0S56_RS09125	COG0745	RESPONSE REGULATOR receiver
H0S56_RS09130	COG0642	Histidine kinase
H0S56_RS09140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S56_RS09145	COG2072	flavoprotein involved in K transport
H0S56_RS09150	COG0431	NADPH-dependent FMN reductase
H0S56_RS09155	COG0798	PFAM Bile acid sodium symporter
H0S56_RS09165	COG0640	Transcriptional regulator
H0S56_RS09180	COG2203	Gaf domain
H0S56_RS09180	COG2199	diguanylate cyclase activity
H0S56_RS09205	COG0714	Associated with various cellular activities
H0S56_RS09210	COG2879	small protein
H0S56_RS09215	COG1966	Carbon starvation protein
H0S56_RS09220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0S56_RS09225	COG1509	lysine 2,3-aminomutase activity
H0S56_RS09240	COG0254	rRNA binding
H0S56_RS09260	COG1067	ATP-dependent peptidase activity
H0S56_RS09265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S56_RS09270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S56_RS09275	COG0583	DNA-binding transcription factor activity
H0S56_RS09285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0S56_RS09300	COG1686	Belongs to the peptidase S11 family
H0S56_RS09305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S56_RS09310	COG3293	Transposase
H0S56_RS09335	COG0482	sulfurtransferase activity
H0S56_RS09340	COG2915	High frequency lysogenization protein hflD homolog
H0S56_RS09365	COG0616	signal peptide processing
H0S56_RS09375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S56_RS09385	COG0573	inorganic phosphate transmembrane transporter activity
H0S56_RS09390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S56_RS09395	COG0076	glutamate decarboxylase activity
H0S56_RS09400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S56_RS09415	COG0671	phosphoesterase, PA-phosphatase related
H0S56_RS09420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0S56_RS09430	COG1733	regulation of RNA biosynthetic process
H0S56_RS09460	COG0556	nucleotide-excision repair
H0S56_RS09485	COG2175	clavaminate synthase activity
H0S56_RS09495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S56_RS09500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S56_RS09505	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS09515	COG2084	Dehydrogenase
H0S56_RS09520	COG2233	PERMEase
H0S56_RS09525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S56_RS09530	COG0251	oxidation-reduction process
H0S56_RS09535	COG1335	isochorismatase
H0S56_RS09540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S56_RS09545	COG0596	Alpha beta hydrolase
H0S56_RS09555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S56_RS09560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S56_RS09565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S56_RS09605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S56_RS09620	COG0174	glutamine synthetase
H0S56_RS09625	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S56_RS09630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S56_RS09645	COG0302	gtp cyclohydrolase
H0S56_RS09660	COG3706	GGDEF domain
H0S56_RS09675	COG3739	integral membrane protein
H0S56_RS09690	COG1741	Belongs to the pirin family
H0S56_RS09705	COG1902	pentaerythritol trinitrate reductase activity
H0S56_RS09705	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S56_RS09720	COG2203	Gaf domain
H0S56_RS09720	COG4251	negative regulation of phosphorylation
H0S56_RS09720	COG5001	Diguanylate cyclase
H0S56_RS09720	COG3706	GGDEF domain
H0S56_RS09725	COG0418	dihydroorotase activity
H0S56_RS09740	COG4771	TonB-dependent receptor
H0S56_RS09755	COG0833	amino acid
H0S56_RS09795	COG4239	(ABC) transporter, permease
H0S56_RS09800	COG4174	ABC transporter (Permease)
H0S56_RS09805	COG4166	transmembrane transport
H0S56_RS09810	COG0741	lytic transglycosylase activity
H0S56_RS09810	COG0741	lytic transglycosylase activity
H0S56_RS09810	COG1388	LysM domain
H0S56_RS09810	COG1388	LysM domain
H0S56_RS09830	COG0657	acetylesterase activity
H0S56_RS09845	COG3107	peptidoglycan biosynthetic process
H0S56_RS09860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S56_RS09865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S56_RS09875	COG2155	Conserved Protein
H0S56_RS09880	COG0006	proline dipeptidase activity
H0S56_RS09915	COG1802	Transcriptional regulator
H0S56_RS09940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S56_RS09950	COG2234	aminopeptidase activity
H0S56_RS09960	COG3384	dioxygenase
H0S56_RS09970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S56_RS09975	COG2878	Part of a membrane complex involved in electron transport
H0S56_RS09980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S56_RS10005	COG0768	penicillin binding
H0S56_RS10010	COG0742	ribosomal rna small subunit methyltransferase
H0S56_RS10070	COG1597	lipid kinase activity
H0S56_RS10095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0S56_RS10120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S56_RS10120	COG3321	synthase
H0S56_RS10120	COG4221	oxidoreductase activity
H0S56_RS10120	COG0604	alcohol dehydrogenase
H0S56_RS10125	COG3118	belongs to the thioredoxin family
H0S56_RS10150	COG3293	Transposase
H0S56_RS10160	COG2268	Band 7 protein
H0S56_RS10175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S56_RS10195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S56_RS10200	COG1053	succinate dehydrogenase
H0S56_RS10205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S56_RS10240	COG0589	response to stress
H0S56_RS10260	COG2321	neutral zinc metallopeptidase
H0S56_RS10265	COG2354	Protein conserved in bacteria
H0S56_RS10290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0S56_RS10295	COG1773	rubredoxin
H0S56_RS10300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S56_RS10305	COG2267	carboxylic ester hydrolase activity
H0S56_RS10310	COG0583	DNA-binding transcription factor activity
H0S56_RS10325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S56_RS10335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S56_RS10340	COG4181	ATPase activity
H0S56_RS10365	COG4771	TonB-dependent receptor
H0S56_RS10385	COG0306	phosphate transporter
H0S56_RS10400	COG2852	Protein conserved in bacteria
H0S56_RS10405	COG2376	Dihydroxyacetone kinase
H0S56_RS10410	COG2066	Belongs to the glutaminase family
H0S56_RS10415	COG3706	GGDEF domain
H0S56_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_RS10430	COG0525	valine-tRNA ligase activity
H0S56_RS10445	COG2852	Protein conserved in bacteria
H0S56_RS10460	COG2323	membrane
H0S56_RS10465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S56_RS10485	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S56_RS10500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S56_RS10510	COG0142	geranyltranstransferase activity
H0S56_RS10515	COG2828	Protein conserved in bacteria
H0S56_RS10520	COG1113	amino acid transport
H0S56_RS10550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S56_RS10570	COG0424	maF-like protein
H0S56_RS10575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0S56_RS10580	COG1792	Involved in formation and maintenance of cell shape
H0S56_RS10585	COG1077	Cell shape determining protein MreB Mrl
H0S56_RS10590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S56_RS10600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S56_RS10615	COG3293	Transposase
H0S56_RS10635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0S56_RS10650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0S56_RS10655	COG2223	nitrite transmembrane transporter activity
H0S56_RS10665	COG0500	methyltransferase
H0S56_RS10690	COG0783	Belongs to the Dps family
H0S56_RS10695	COG1136	(ABC) transporter
H0S56_RS10700	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0S56_RS10715	COG2271	Major facilitator Superfamily
H0S56_RS10740	COG3177	Filamentation induced by cAMP protein fic
H0S56_RS10785	COG3586	endonuclease activity
H0S56_RS10840	COG0582	viral genome integration into host DNA
H0S56_RS10850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S56_RS10855	COG2050	protein possibly involved in aromatic compounds catabolism
H0S56_RS10865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S56_RS10870	COG1090	epimerase
H0S56_RS10880	COG0420	3'-5' exonuclease activity
H0S56_RS10895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0S56_RS10910	COG0735	belongs to the Fur family
H0S56_RS10915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S56_RS10920	COG2914	Belongs to the UPF0125 (RnfH) family
H0S56_RS10935	COG0121	glutamine amidotransferase
H0S56_RS10940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S56_RS10945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S56_RS10955	COG0756	dUTP diphosphatase activity
H0S56_RS10960	COG0210	DNA helicase
H0S56_RS10965	COG2885	chlorophyll binding
H0S56_RS10970	COG0204	Acyl-transferase
H0S56_RS10985	COG2894	cell division
H0S56_RS11000	COG1674	ftsk spoiiie
H0S56_RS11000	COG0531	amino acid
H0S56_RS11005	COG0492	ferredoxin-NADP+ reductase activity
H0S56_RS11010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S56_RS11020	COG0456	acetyltransferase
H0S56_RS11030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S56_RS11035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0S56_RS11045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S56_RS11060	COG1981	membrane
H0S56_RS11065	COG1113	amino acid transport
H0S56_RS11070	COG0251	oxidation-reduction process
H0S56_RS11090	COG1652	LysM domain
H0S56_RS11095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S56_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_RS11105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0S56_RS11115	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S56_RS11120	COG3101	peptidyl-lysine hydroxylation
H0S56_RS11125	COG0009	L-threonylcarbamoyladenylate synthase
H0S56_RS11140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S56_RS11145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S56_RS11170	COG0339	signal peptide processing
H0S56_RS11180	COG4166	transmembrane transport
H0S56_RS11210	COG2193	ferroxidase activity
H0S56_RS11215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S56_RS11220	COG3385	transposase activity
H0S56_RS11225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0S56_RS11235	COG1196	nuclear chromosome segregation
H0S56_RS11245	COG0730	response to heat
H0S56_RS11270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S56_RS11280	COG4106	trans-aconitate 2-methyltransferase activity
H0S56_RS11290	COG3327	negative regulation of DNA-templated transcription, initiation
H0S56_RS11295	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0S56_RS11300	COG0183	Belongs to the thiolase family
H0S56_RS11305	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_RS11310	COG1024	Enoyl-CoA hydratase
H0S56_RS11315	COG1024	Enoyl-CoA hydratase
H0S56_RS11320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S56_RS11325	COG2151	metal-sulfur cluster biosynthetic enzyme
H0S56_RS11330	COG3396	Phenylacetate-CoA oxygenase
H0S56_RS11335	COG3460	Phenylacetate-CoA oxygenase
H0S56_RS11340	COG3396	Phenylacetate-CoA oxygenase
H0S56_RS11345	COG2030	dehydratase
H0S56_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
H0S56_RS11350	COG2814	Major facilitator Superfamily
H0S56_RS11360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S56_RS11370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S56_RS11405	COG1968	undecaprenyl-diphosphatase activity
H0S56_RS11410	COG1214	PFAM Peptidase M22, glycoprotease
H0S56_RS11420	COG0494	nUDIX hydrolase
H0S56_RS11470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S56_RS11475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S56_RS11540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S56_RS11545	COG1764	response to oxidative stress
H0S56_RS11590	COG0037	tRNA processing
H0S56_RS11600	COG0248	Ppx GppA phosphatase
H0S56_RS11625	COG0072	phenylalanine-tRNA ligase activity
H0S56_RS11655	COG1238	metal cluster binding
H0S56_RS11670	COG0625	glutathione transferase activity
H0S56_RS11685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0S56_RS11705	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_RS11720	COG4206	TonB-dependent receptor
H0S56_RS11725	COG2096	Adenosyltransferase
H0S56_RS11740	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0S56_RS11755	COG0745	RESPONSE REGULATOR receiver
H0S56_RS11760	COG2205	protein histidine kinase activity
H0S56_RS11770	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS11775	COG1960	acyl-CoA dehydrogenase activity
H0S56_RS11820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0S56_RS11865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S56_RS11875	COG2205	protein histidine kinase activity
H0S56_RS11890	COG1660	Displays ATPase and GTPase activities
H0S56_RS11905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S56_RS11910	COG0617	tRNA 3'-terminal CCA addition
H0S56_RS11915	COG1596	polysaccharide export
H0S56_RS11915	COG1555	photosystem II stabilization
H0S56_RS11920	COG3956	TIGRFAM MazG family protein
H0S56_RS11925	COG0300	oxidoreductase activity
H0S56_RS11940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S56_RS11960	COG1426	Protein conserved in bacteria
H0S56_RS11980	COG2975	iron-sulfur cluster assembly
H0S56_RS12010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0S56_RS12015	COG0440	acetolactate synthase activity
H0S56_RS12020	COG0028	Belongs to the TPP enzyme family
H0S56_RS12045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S56_RS12050	COG0577	efflux transmembrane transporter activity
H0S56_RS12050	COG1136	(ABC) transporter
H0S56_RS12055	COG1538	Outer membrane efflux protein
H0S56_RS12065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S56_RS12070	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S56_RS12075	COG1162	GTPase activity
H0S56_RS12085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S56_RS12100	COG0084	hydrolase, TatD family'
H0S56_RS12115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S56_RS12125	COG0793	Belongs to the peptidase S41A family
H0S56_RS12150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S56_RS12155	COG0280	phosphate acetyltransferase
H0S56_RS12155	COG0857	belongs to the CobB CobQ family
H0S56_RS12165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S56_RS12165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S56_RS12180	COG0740	serine-type endopeptidase activity
H0S56_RS12190	COG4771	TonB-dependent receptor
H0S56_RS12195	COG4774	siderophore transport
H0S56_RS12205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S56_RS12215	COG2813	Specifically methylates the guanine in position
H0S56_RS12215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S56_RS12330	COG0788	formyltetrahydrofolate deformylase activity
H0S56_RS12355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S56_RS12355	COG4651	solute:proton antiporter activity
H0S56_RS12375	COG0210	DNA helicase
H0S56_RS12380	COG1929	Belongs to the glycerate kinase type-1 family
H0S56_RS12410	COG2900	Belongs to the SlyX family
H0S56_RS12415	COG0488	(ABC) transporter
H0S56_RS12420	COG1560	Kdo2-lipid A biosynthetic process
H0S56_RS12480	COG0473	3-isopropylmalate dehydrogenase activity
H0S56_RS12495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0S56_RS12505	COG0583	DNA-binding transcription factor activity
H0S56_RS12555	COG0753	catalase activity
H0S56_RS12560	COG3011	Protein conserved in bacteria
H0S56_RS12585	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S56_RS12590	COG3384	dioxygenase
H0S56_RS12595	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_RS12610	COG4638	Rieske (2fe-2S)
H0S56_RS12615	COG0583	DNA-binding transcription factor activity
H0S56_RS12635	COG4569	acetaldehyde dehydrogenase (acetylating) activity
H0S56_RS12640	COG3971	2-oxopent-4-enoate hydratase activity
H0S56_RS12645	COG0546	phosphoglycolate phosphatase activity
H0S56_RS12650	COG0564	pseudouridine synthase activity
H0S56_RS12655	COG1530	ribonuclease E activity
H0S56_RS12660	COG0318	PFAM AMP-dependent synthetase and ligase
H0S56_RS12685	COG1983	PspC domain protein
H0S56_RS12695	COG0471	metal ion transport
H0S56_RS12715	COG0751	glycine-tRNA ligase activity
H0S56_RS12735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0S56_RS12760	COG0493	'glutamate synthase
H0S56_RS12770	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S56_RS12775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S56_RS12790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S56_RS12800	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S56_RS12800	COG0644	oxidoreductase
H0S56_RS12810	COG0425	Belongs to the sulfur carrier protein TusA family
H0S56_RS12815	COG4535	Mg2 and Co2 transporter CorC
H0S56_RS12820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0S56_RS12840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S56_RS12850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0S56_RS12860	COG0789	Transcriptional regulator
H0S56_RS12865	COG2841	Protein conserved in bacteria
H0S56_RS12870	COG1185	polyribonucleotide nucleotidyltransferase activity
H0S56_RS12875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0S56_RS12880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S56_RS12885	COG1074	ATP-dependent DNA helicase activity
H0S56_RS12890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S56_RS12920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S56_RS12950	COG0427	acetyl-CoA hydrolase
H0S56_RS12955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S56_RS12985	COG0326	Molecular chaperone. Has ATPase activity
H0S56_RS12995	COG3047	cAMP biosynthetic process
H0S56_RS13000	COG2056	Na+-H+ antiporter family
H0S56_RS13020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0S56_RS13025	COG0085	RNA polymerase activity
H0S56_RS13030	COG0222	ribosome binding
H0S56_RS13035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0S56_RS13040	COG0081	regulation of translation
H0S56_RS13065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S56_RS13095	COG0546	phosphoglycolate phosphatase activity
H0S56_RS13125	COG0824	Thioesterase
H0S56_RS13145	COG0181	hydroxymethylbilane synthase activity
H0S56_RS13155	COG3275	phosphorelay sensor kinase activity
H0S56_RS13175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S56_RS13200	COG1024	Enoyl-CoA hydratase
H0S56_RS13200	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S56_RS13275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S56_RS13310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S56_RS13345	COG3158	transport of potassium into the cell
H0S56_RS13370	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H0S56_RS13385	COG2814	Major facilitator Superfamily
H0S56_RS13395	COG0351	phosphomethylpyrimidine kinase
H0S56_RS13395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S56_RS13395	COG0352	thiamine-phosphate diphosphorylase activity
H0S56_RS13440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S56_RS13450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S56_RS13455	COG3162	membrane
H0S56_RS13460	COG2205	protein histidine kinase activity
H0S56_RS13460	COG0784	Response regulator, receiver
H0S56_RS13475	COG0431	NADPH-dependent FMN reductase
H0S56_RS13485	COG0415	Belongs to the DNA photolyase family
H0S56_RS13495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S56_RS13500	COG3152	Membrane
H0S56_RS13505	COG0668	transmembrane transport
H0S56_RS13510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S56_RS13515	COG1519	Transferase
H0S56_RS13520	COG1902	pentaerythritol trinitrate reductase activity
H0S56_RS13545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S56_RS13570	COG0426	domain, Protein
H0S56_RS13570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S56_RS13575	COG2119	membrane
H0S56_RS13580	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S56_RS13615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S56_RS13625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S56_RS13640	COG0189	ligase activity
H0S56_RS13655	COG2132	Multicopper oxidase
H0S56_RS13670	COG1278	Cold shock
H0S56_RS13675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0S56_RS13680	COG0708	Exodeoxyribonuclease III
H0S56_RS13710	COG3706	GGDEF domain
H0S56_RS13740	COG1247	-acetyltransferase
H0S56_RS13785	COG3150	esterase
H0S56_RS13795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H0S56_RS13800	COG2918	glutathione biosynthetic process
H0S56_RS13815	COG2733	membrane
H0S56_RS13855	COG0753	catalase activity
H0S56_RS13890	COG0385	Bile acid
H0S56_RS13895	COG1335	isochorismatase
H0S56_RS13900	COG2814	Major facilitator Superfamily
H0S56_RS13905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S56_RS13915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0S56_RS13920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0S56_RS13925	COG5001	Diguanylate cyclase
H0S56_RS13925	COG3300	MHYT domain
H0S56_RS13930	COG2983	Belongs to the UPF0260 family
H0S56_RS13935	COG5487	UPF0391 membrane protein
H0S56_RS13940	COG0728	peptidoglycan biosynthetic process
H0S56_RS13945	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0S56_RS13960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S56_RS13970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S56_RS13975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0S56_RS13980	COG0546	phosphoglycolate phosphatase activity
H0S56_RS13985	COG1028	Short-chain dehydrogenase reductase Sdr
H0S56_RS14010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S56_RS14010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0S56_RS14015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S56_RS14020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S56_RS14025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S56_RS14030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S56_RS14035	COG1116	anion transmembrane transporter activity
H0S56_RS14040	COG1309	transcriptional regulator
H0S56_RS14050	COG0196	riboflavin kinase activity
H0S56_RS14055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S56_RS14060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0S56_RS14065	COG1047	Peptidyl-prolyl cis-trans
H0S56_RS14080	COG2133	pyrroloquinoline quinone binding
H0S56_RS14115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S56_RS14120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S56_RS14125	COG2951	lytic endotransglycosylase activity
H0S56_RS14130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S56_RS14145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S56_RS14170	COG2388	GCN5-related N-acetyl-transferase
H0S56_RS14175	COG2814	Major facilitator Superfamily
H0S56_RS14180	COG0861	Integral membrane protein TerC family
H0S56_RS14190	COG0402	S-adenosylhomocysteine deaminase activity
H0S56_RS14220	COG0706	membrane insertase activity
H0S56_RS14225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0S56_RS14230	COG0594	ribonuclease P activity