locus-tag	class	description
DKE50_RS00060	COG0596	Alpha beta hydrolase
DKE50_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE50_RS00205	COG2814	Major facilitator Superfamily
DKE50_RS00210	COG0656	L-ascorbic acid biosynthetic process
DKE50_RS00235	COG1064	alcohol dehydrogenase
DKE50_RS00255	COG1194	a g-specific adenine glycosylase
DKE50_RS00270	COG5487	UPF0391 membrane protein
DKE50_RS00325	COG1335	isochorismatase
DKE50_RS00330	COG0385	Bile acid
DKE50_RS00335	COG0534	Mate efflux family protein
DKE50_RS00360	COG0625	glutathione transferase activity
DKE50_RS00435	COG0546	phosphoglycolate phosphatase activity
DKE50_RS00440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE50_RS00545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKE50_RS00550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DKE50_RS00660	COG0436	Aminotransferase
DKE50_RS00665	COG2733	membrane
DKE50_RS00810	COG2351	hydroxyisourate hydrolase activity
DKE50_RS00865	COG1393	Belongs to the ArsC family
DKE50_RS00870	COG0708	Exodeoxyribonuclease III
DKE50_RS00915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKE50_RS00960	COG2119	membrane
DKE50_RS00965	COG0426	domain, Protein
DKE50_RS00965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_RS01015	COG1519	Transferase
DKE50_RS01045	COG1522	sequence-specific DNA binding
DKE50_RS01075	COG3162	membrane
DKE50_RS01080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE50_RS01110	COG1309	transcriptional regulator
DKE50_RS01265	COG0583	DNA-binding transcription factor activity
DKE50_RS01285	COG0667	Aldo Keto reductase
DKE50_RS01335	COG1733	regulation of RNA biosynthetic process
DKE50_RS01535	COG2329	Antibiotic biosynthesis monooxygenase
DKE50_RS01625	COG0659	secondary active sulfate transmembrane transporter activity
DKE50_RS01760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKE50_RS01775	COG2226	methyltransferase
DKE50_RS01830	COG0493	'glutamate synthase
DKE50_RS01840	COG1704	LemA family
DKE50_RS01950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE50_RS01970	COG5380	lipid catabolic process
DKE50_RS02020	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE50_RS02025	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE50_RS02045	COG2032	superoxide dismutase activity
DKE50_RS02095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE50_RS02165	COG0752	glycyl-tRNA synthetase alpha subunit
DKE50_RS02245	COG1127	ABC transporter
DKE50_RS02250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE50_RS02280	COG0494	nUDIX hydrolase
DKE50_RS02285	COG1040	competence protein
DKE50_RS02310	COG1946	Acyl-CoA thioesterase
DKE50_RS02335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE50_RS02335	COG1017	nitric oxide dioxygenase activity
DKE50_RS02510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKE50_RS02540	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE50_RS02595	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE50_RS02600	COG2207	Transcriptional regulator
DKE50_RS02690	COG1183	phosphatidylcholine synthase activity
DKE50_RS02805	COG2969	positive regulation of protein catabolic process
DKE50_RS02815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE50_RS02830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE50_RS02855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKE50_RS02945	COG1607	acyl-coa hydrolase
DKE50_RS02995	COG3781	membrane
DKE50_RS03010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE50_RS03020	COG1862	Preprotein translocase
DKE50_RS03265	COG0285	dihydrofolate synthase activity
DKE50_RS03380	COG0183	Belongs to the thiolase family
DKE50_RS03450	COG1902	pentaerythritol trinitrate reductase activity
DKE50_RS03485	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE50_RS03700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE50_RS03705	COG1077	Cell shape determining protein MreB Mrl
DKE50_RS03710	COG1792	Involved in formation and maintenance of cell shape
DKE50_RS03720	COG0424	maF-like protein
DKE50_RS03725	COG1530	ribonuclease E activity
DKE50_RS03755	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE50_RS03825	COG2816	NAD+ diphosphatase activity
DKE50_RS03845	COG2315	Protein conserved in bacteria
DKE50_RS03860	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE50_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_RS03950	COG0393	Putative heavy-metal-binding
DKE50_RS03955	COG0393	Putative heavy-metal-binding
DKE50_RS04005	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKE50_RS04025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE50_RS04040	COG0531	amino acid
DKE50_RS04060	COG2921	Belongs to the UPF0250 family
DKE50_RS04095	COG2009	succinate dehydrogenase
DKE50_RS04100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DKE50_RS04155	COG2354	Protein conserved in bacteria
DKE50_RS04160	COG2321	neutral zinc metallopeptidase
DKE50_RS04270	COG0589	response to stress
DKE50_RS04285	COG1309	transcriptional regulator
DKE50_RS04300	COG0505	Belongs to the CarA family
DKE50_RS04515	COG2814	Major facilitator Superfamily
DKE50_RS04635	COG3811	Belongs to the UPF0386 family
DKE50_RS04755	COG0778	Nitroreductase
DKE50_RS04770	COG1929	Belongs to the glycerate kinase type-1 family
DKE50_RS04780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE50_RS04785	COG3339	Conserved Protein
DKE50_RS04840	COG1280	lysine exporter protein (LysE YggA)
DKE50_RS04950	COG1136	(ABC) transporter
DKE50_RS04975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE50_RS05060	COG0824	Thioesterase
DKE50_RS05095	COG2814	Major facilitator Superfamily
DKE50_RS05110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE50_RS05115	COG1024	Enoyl-CoA hydratase
DKE50_RS05155	COG0602	queuosine metabolic process
DKE50_RS05175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKE50_RS05185	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKE50_RS05200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DKE50_RS05260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DKE50_RS05415	COG1215	transferase activity, transferring glycosyl groups
DKE50_RS05430	COG3293	Transposase
DKE50_RS05450	COG1252	NADH dehydrogenase
DKE50_RS05505	COG1823	symporter activity
DKE50_RS05690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE50_RS05695	COG1686	Belongs to the peptidase S11 family
DKE50_RS05765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKE50_RS05820	COG1741	Belongs to the pirin family
DKE50_RS05860	COG0302	gtp cyclohydrolase
DKE50_RS05920	COG0174	glutamine synthetase
DKE50_RS05930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DKE50_RS05965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE50_RS05970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE50_RS05995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKE50_RS06000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE50_RS06025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE50_RS06095	COG2951	lytic endotransglycosylase activity
DKE50_RS06125	COG0582	viral genome integration into host DNA
DKE50_RS06505	COG4160	amino acid transport
DKE50_RS06525	COG0826	peptidase U32
DKE50_RS06535	COG0384	phenazine biosynthesis protein PhzF
DKE50_RS06545	COG1720	tRNA m6t6A37 methyltransferase activity
DKE50_RS06560	COG3111	PFAM Bacterial OB fold (BOF) protein
DKE50_RS06570	COG0642	Histidine kinase
DKE50_RS06580	COG0494	nUDIX hydrolase
DKE50_RS06595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE50_RS06600	COG3139	Protein of unknown function (DUF1315)
DKE50_RS06620	COG1960	acyl-CoA dehydrogenase activity
DKE50_RS06685	COG2363	Small membrane protein
DKE50_RS06700	COG1278	Cold shock
DKE50_RS06745	COG1286	toxin biosynthetic process
DKE50_RS06775	COG1610	YqeY-like protein
DKE50_RS06895	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DKE50_RS06935	COG2801	Transposase and inactivated derivatives
DKE50_RS07000	COG2226	methyltransferase
DKE50_RS07040	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_RS07155	COG2995	paraquat-inducible protein a
DKE50_RS07170	COG2351	hydroxyisourate hydrolase activity
DKE50_RS07185	COG5002	protein histidine kinase activity
DKE50_RS07210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DKE50_RS07225	COG0642	Histidine kinase
DKE50_RS07230	COG0745	RESPONSE REGULATOR receiver
DKE50_RS07270	COG1301	dicarboxylic acid transport
DKE50_RS07315	COG0151	Belongs to the GarS family
DKE50_RS07325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DKE50_RS07370	COG1305	Transglutaminase-like
DKE50_RS07410	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE50_RS07420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE50_RS07475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE50_RS07510	COG2890	protein-(glutamine-N5) methyltransferase activity
DKE50_RS07545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_RS07580	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DKE50_RS07685	COG3620	sequence-specific DNA binding
DKE50_RS08030	COG0802	atpase or kinase
DKE50_RS08045	COG1923	regulation of RNA biosynthetic process
DKE50_RS08080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE50_RS08080	COG0519	Catalyzes the synthesis of GMP from XMP
DKE50_RS08095	COG0531	amino acid
DKE50_RS08130	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DKE50_RS08195	COG0625	glutathione transferase activity
DKE50_RS08210	COG1605	Chorismate mutase
DKE50_RS08280	COG0668	transmembrane transport
DKE50_RS08325	COG0488	(ABC) transporter
DKE50_RS08445	COG1454	alcohol dehydrogenase
DKE50_RS08470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKE50_RS08560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DKE50_RS08560	COG1116	anion transmembrane transporter activity
DKE50_RS08565	COG0745	RESPONSE REGULATOR receiver
DKE50_RS08580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE50_RS08605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKE50_RS08660	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DKE50_RS08665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE50_RS08805	COG2137	regulation of response to DNA damage stimulus
DKE50_RS08870	COG0659	secondary active sulfate transmembrane transporter activity
DKE50_RS08875	COG0659	secondary active sulfate transmembrane transporter activity
DKE50_RS08885	COG3328	transposase activity
DKE50_RS08965	COG0583	DNA-binding transcription factor activity
DKE50_RS08980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE50_RS08985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DKE50_RS08985	COG0517	IMP dehydrogenase activity
DKE50_RS09035	COG4890	Cyd operon protein YbgT
DKE50_RS09090	COG0569	domain protein
DKE50_RS09125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKE50_RS09195	COG2323	membrane
DKE50_RS09205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE50_RS09215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE50_RS09240	COG2271	Major facilitator Superfamily
DKE50_RS09245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE50_RS09255	COG3485	protocatechuate 3,4-dioxygenase
DKE50_RS09285	COG2391	methyltransferase activity
DKE50_RS09305	COG0583	DNA-binding transcription factor activity
DKE50_RS09385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_RS09425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE50_RS09440	COG4829	muconolactone delta-isomerase
DKE50_RS09460	COG2186	Transcriptional regulator
DKE50_RS09505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DKE50_RS09555	COG1309	transcriptional regulator
DKE50_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
DKE50_RS09665	COG2084	Dehydrogenase
DKE50_RS09680	COG1120	ATPase activity
DKE50_RS09700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE50_RS09765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DKE50_RS09810	COG4221	oxidoreductase activity
DKE50_RS09850	COG0745	RESPONSE REGULATOR receiver
DKE50_RS09900	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE50_RS09935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE50_RS10015	COG1535	isochorismatase
DKE50_RS10015	COG3433	isochorismatase activity
DKE50_RS10080	COG4149	molybdate abc transporter
DKE50_RS10085	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE50_RS10100	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE50_RS10120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE50_RS10215	COG0183	Belongs to the thiolase family
DKE50_RS10220	COG0583	DNA-binding transcription factor activity
DKE50_RS10320	COG0730	response to heat
DKE50_RS10350	COG1063	alcohol dehydrogenase
DKE50_RS10360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE50_RS10370	COG0022	dehydrogenase e1 component
DKE50_RS10375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE50_RS10380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE50_RS10395	COG3706	GGDEF domain
DKE50_RS10420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE50_RS10480	COG2226	methyltransferase
DKE50_RS10565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE50_RS10590	COG0730	response to heat
DKE50_RS10650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKE50_RS10670	COG1960	acyl-CoA dehydrogenase activity
DKE50_RS10675	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKE50_RS10680	COG2207	Transcriptional regulator
DKE50_RS10805	COG4172	Belongs to the ABC transporter superfamily
DKE50_RS10975	COG0084	hydrolase, TatD family'
DKE50_RS11050	COG0191	fructose-bisphosphate aldolase activity
DKE50_RS11075	COG2850	peptidyl-arginine hydroxylation
DKE50_RS11085	COG0640	Transcriptional regulator
DKE50_RS11100	COG3122	Protein conserved in bacteria
DKE50_RS11105	COG1132	(ABC) transporter
DKE50_RS11125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKE50_RS11130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE50_RS11145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE50_RS11170	COG2353	YceI-like domain
DKE50_RS11250	COG3121	Chaperone
DKE50_RS11280	COG0697	spore germination
DKE50_RS11320	COG1309	transcriptional regulator
DKE50_RS11340	COG1522	sequence-specific DNA binding
DKE50_RS11405	COG2011	ABC-type metal ion transport system permease component
DKE50_RS11435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DKE50_RS11575	COG1271	oxidase subunit
DKE50_RS11590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE50_RS11625	COG1346	cytolysis
DKE50_RS11635	COG0583	DNA-binding transcription factor activity
DKE50_RS11645	COG0625	glutathione transferase activity
DKE50_RS11650	COG0583	DNA-binding transcription factor activity
DKE50_RS11700	COG1126	abc transporter atp-binding protein
DKE50_RS11875	COG1309	transcriptional regulator
DKE50_RS11880	COG1960	acyl-CoA dehydrogenase activity
DKE50_RS11940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE50_RS11960	COG1024	Enoyl-CoA hydratase
DKE50_RS12015	COG1960	acyl-CoA dehydrogenase activity
DKE50_RS12075	COG0583	DNA-binding transcription factor activity
DKE50_RS12100	COG1073	alpha beta
DKE50_RS12115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE50_RS12160	COG0406	alpha-ribazole phosphatase activity
DKE50_RS12170	COG2050	protein possibly involved in aromatic compounds catabolism
DKE50_RS12180	COG3327	negative regulation of DNA-templated transcription, initiation
DKE50_RS12205	COG1024	Enoyl-CoA hydratase
DKE50_RS12225	COG3460	Phenylacetate-CoA oxygenase
DKE50_RS12230	COG3396	Phenylacetate-CoA oxygenase
DKE50_RS12240	COG1760	l-serine dehydratase
DKE50_RS12250	COG0789	Transcriptional regulator
DKE50_RS12265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKE50_RS12285	COG0590	tRNA wobble adenosine to inosine editing
DKE50_RS12330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE50_RS12340	COG0864	Transcriptional regulator
DKE50_RS12355	COG1733	regulation of RNA biosynthetic process
DKE50_RS12405	COG2801	Transposase and inactivated derivatives
DKE50_RS12455	COG1914	H( )-stimulated, divalent metal cation uptake system
DKE50_RS12480	COG3220	belongs to the UPF0276 family
DKE50_RS12505	COG3713	MltA-interacting MipA family protein
DKE50_RS12510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE50_RS12570	COG2801	Transposase and inactivated derivatives
DKE50_RS12645	COG1278	Cold shock
DKE50_RS12665	COG1522	sequence-specific DNA binding
DKE50_RS12740	COG1960	acyl-CoA dehydrogenase activity
DKE50_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_RS12755	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_RS12775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE50_RS12785	COG4122	O-methyltransferase activity
DKE50_RS12820	COG1137	ATPase activity
DKE50_RS12825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE50_RS12840	COG0517	IMP dehydrogenase activity
DKE50_RS12840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DKE50_RS13030	COG2871	sodium ion transport
DKE50_RS13050	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE50_RS13110	COG3634	alkyl hydroperoxide reductase activity
DKE50_RS13130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE50_RS13135	COG0625	glutathione transferase activity
DKE50_RS13205	COG0667	Aldo Keto reductase
DKE50_RS13220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE50_RS13335	COG3567	Phage-associated protein, HI1409 family
DKE50_RS13340	COG5410	chromosome segregation
DKE50_RS13440	COG1309	transcriptional regulator
DKE50_RS13530	COG1024	Enoyl-CoA hydratase
DKE50_RS13535	COG1012	belongs to the aldehyde dehydrogenase family
DKE50_RS13565	COG0697	spore germination
DKE50_RS13770	COG4239	(ABC) transporter, permease
DKE50_RS13940	COG3384	dioxygenase
DKE50_RS13990	COG0742	ribosomal rna small subunit methyltransferase
DKE50_RS14120	COG1773	rubredoxin
DKE50_RS14290	COG0242	peptide deformylase activity
DKE50_RS14350	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_RS14370	COG1414	Transcriptional regulator
DKE50_RS14395	COG1024	Enoyl-CoA hydratase
DKE50_RS14420	COG4681	YaeQ
DKE50_RS14440	COG1607	acyl-coa hydrolase
DKE50_RS14485	COG2040	homocysteine
DKE50_RS14670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DKE50_RS14900	COG0420	3'-5' exonuclease activity
DKE50_RS14910	COG1968	undecaprenyl-diphosphatase activity
DKE50_RS14930	COG0735	belongs to the Fur family
DKE50_RS14935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE50_RS14980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKE50_RS14990	COG0210	DNA helicase
DKE50_RS14995	COG2885	chlorophyll binding
DKE50_RS15055	COG0456	acetyltransferase
DKE50_RS15120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE50_RS15120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DKE50_RS15140	COG1012	belongs to the aldehyde dehydrogenase family
DKE50_RS15150	COG0657	acetylesterase activity
DKE50_RS15195	COG0582	viral genome integration into host DNA
DKE50_RS15550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE50_RS15580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE50_RS15590	COG0352	thiamine-phosphate diphosphorylase activity
DKE50_RS15590	COG0351	phosphomethylpyrimidine kinase
DKE50_RS15590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE50_RS15620	COG1399	metal-binding, possibly nucleic acid-binding protein
DKE50_RS15625	COG3101	peptidyl-lysine hydroxylation
DKE50_RS15630	COG0009	L-threonylcarbamoyladenylate synthase
DKE50_RS15640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE50_RS15680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DKE50_RS15715	COG0730	response to heat
DKE50_RS15845	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DKE50_RS15880	COG0583	DNA-binding transcription factor activity
DKE50_RS15980	COG0745	RESPONSE REGULATOR receiver
DKE50_RS16035	COG0583	DNA-binding transcription factor activity
DKE50_RS16070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DKE50_RS16090	COG1063	alcohol dehydrogenase
DKE50_RS16390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DKE50_RS16395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKE50_RS16430	COG0561	phosphatase activity
DKE50_RS16445	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE50_RS16515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE50_RS16580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE50_RS16590	COG1846	Transcriptional regulator
DKE50_RS16595	COG1764	response to oxidative stress
DKE50_RS16645	COG0248	Ppx GppA phosphatase
DKE50_RS16700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE50_RS16715	COG0625	glutathione transferase activity
DKE50_RS16740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_RS16770	COG1555	photosystem II stabilization
DKE50_RS16785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKE50_RS16890	COG0492	ferredoxin-NADP+ reductase activity
DKE50_RS16910	COG0640	Transcriptional regulator
DKE50_RS16935	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DKE50_RS17075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE50_RS17095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DKE50_RS17105	COG0084	hydrolase, TatD family'
DKE50_RS17155	COG0440	acetolactate synthase activity
DKE50_RS17215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DKE50_RS17230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE50_RS17250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE50_RS17360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKE50_RS17420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE50_RS17420	COG2813	Specifically methylates the guanine in position
DKE50_RS17600	COG1733	regulation of RNA biosynthetic process
DKE50_RS17610	COG2900	Belongs to the SlyX family
DKE50_RS17695	COG0473	3-isopropylmalate dehydrogenase activity
DKE50_RS17720	COG0583	DNA-binding transcription factor activity
DKE50_RS17765	COG0583	DNA-binding transcription factor activity
DKE50_RS17780	COG0625	glutathione transferase activity
DKE50_RS17785	COG2378	regulation of single-species biofilm formation
DKE50_RS17860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKE50_RS17895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE50_RS17940	COG4535	Mg2 and Co2 transporter CorC
DKE50_RS17950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE50_RS17985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE50_RS18005	COG0598	Magnesium transport protein CorA
DKE50_RS18060	COG2226	methyltransferase
DKE50_RS18070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKE50_RS18105	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE50_RS18110	COG0651	ATP synthesis coupled electron transport
DKE50_RS18120	COG2212	antiporter activity
DKE50_RS18190	COG0237	dephospho-CoA kinase activity
DKE50_RS18200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE50_RS18225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DKE50_RS18240	COG1289	transmembrane transporter activity
DKE50_RS18255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE50_RS18255	COG2169	Transcriptional regulator
DKE50_RS18260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE50_RS18370	COG0596	Alpha beta hydrolase
DKE50_RS18520	COG0181	hydroxymethylbilane synthase activity
DKE50_RS18555	COG0697	spore germination
DKE50_RS18585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE50_RS18595	COG0772	Belongs to the SEDS family
DKE50_RS18620	COG4974	Belongs to the 'phage' integrase family
DKE50_RS18635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE50_RS18670	COG0795	lipopolysaccharide-transporting ATPase activity
DKE50_RS18795	COG0640	Transcriptional regulator
DKE50_RS18805	COG0789	Transcriptional regulator
DKE50_RS18860	COG0606	chelatase, subunit chli
DKE50_RS18870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE50_RS18875	COG0235	Class ii aldolase
DKE50_RS18925	COG2860	membrane
DKE50_RS18990	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE50_RS19040	COG1309	transcriptional regulator
DKE50_RS19115	COG0386	Belongs to the glutathione peroxidase family
DKE50_RS19240	COG0735	belongs to the Fur family
DKE50_RS19250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE50_RS19255	COG0519	Catalyzes the synthesis of GMP from XMP
DKE50_RS19255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE50_RS19260	COG4399	Belongs to the UPF0754 family
DKE50_RS19260	COG4399	Belongs to the UPF0754 family
DKE50_RS19330	COG3756	Protein conserved in bacteria
DKE50_RS19410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DKE50_RS19410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_RS19415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_RS19415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE50_RS19455	COG3916	Acyl-homoserine-lactone synthase
DKE50_RS19460	COG0477	Major facilitator Superfamily
DKE50_RS19465	COG1024	Enoyl-CoA hydratase
DKE50_RS19470	COG1024	Enoyl-CoA hydratase
DKE50_RS19485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE50_RS19515	COG1113	amino acid transport
DKE50_RS19520	COG0251	oxidation-reduction process
DKE50_RS19560	COG0564	pseudouridine synthase activity
DKE50_RS19605	COG1802	Transcriptional regulator
DKE50_RS19630	COG2186	Transcriptional regulator
DKE50_RS19675	COG1216	Glycosyl transferase, family 2
DKE50_RS19770	COG3023	N-Acetylmuramoyl-L-alanine amidase
DKE50_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
DKE50_RS19860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE50_RS19865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE50_RS19880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE50_RS19945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE50_RS19950	COG0657	acetylesterase activity
DKE50_RS20000	COG2951	lytic endotransglycosylase activity
DKE50_RS20020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE50_RS20030	COG3328	transposase activity
DKE50_RS20055	COG0754	glutathionylspermidine amidase activity
DKE50_RS20190	COG3118	belongs to the thioredoxin family
DKE50_RS20275	COG1192	Involved in chromosome partitioning
DKE50_RS20385	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
DKE50_RS20455	COG2801	Transposase and inactivated derivatives
DKE50_RS20545	COG1979	alcohol dehydrogenase
DKE50_RS20565	COG1309	transcriptional regulator
DKE50_RS20635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKE50_RS21005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DKE50_RS21210	COG3657	addiction module killer protein
DKE50_RS21215	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE50_RS21400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE50_RS21565	COG3736	Type IV secretory pathway, component VirB8
DKE50_RS21585	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DKE50_RS21655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone