locus-tag	class	description
GD578_RS00040	COG1047	Peptidyl-prolyl cis-trans
GD578_RS00050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GD578_RS00055	COG0196	riboflavin kinase activity
GD578_RS00065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GD578_RS00070	COG1309	transcriptional regulator
GD578_RS00075	COG1116	anion transmembrane transporter activity
GD578_RS00080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD578_RS00085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GD578_RS00090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD578_RS00095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD578_RS00100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GD578_RS00100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GD578_RS00115	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS00120	COG0546	phosphoglycolate phosphatase activity
GD578_RS00175	COG3023	N-Acetylmuramoyl-L-alanine amidase
GD578_RS00180	COG0728	peptidoglycan biosynthetic process
GD578_RS00205	COG1596	polysaccharide export
GD578_RS00210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GD578_RS00220	COG0463	Glycosyl transferase, family 2
GD578_RS00220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GD578_RS00230	COG0438	transferase activity, transferring glycosyl groups
GD578_RS00240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GD578_RS00245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GD578_RS00260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GD578_RS00270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GD578_RS00280	COG2186	Transcriptional regulator
GD578_RS00290	COG0277	FAD linked oxidase domain protein
GD578_RS00295	COG1448	Aminotransferase
GD578_RS00305	COG1802	Transcriptional regulator
GD578_RS00320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GD578_RS00425	COG0564	pseudouridine synthase activity
GD578_RS00465	COG0251	oxidation-reduction process
GD578_RS00470	COG1113	amino acid transport
GD578_RS00475	COG1113	amino acid transport
GD578_RS00495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GD578_RS00500	COG1960	acyl-CoA dehydrogenase activity
GD578_RS00505	COG1024	Enoyl-CoA hydratase
GD578_RS00510	COG1024	Enoyl-CoA hydratase
GD578_RS00515	COG0477	Major facilitator Superfamily
GD578_RS00520	COG3916	Acyl-homoserine-lactone synthase
GD578_RS00530	COG2197	response regulator
GD578_RS00535	COG0318	PFAM AMP-dependent synthetase and ligase
GD578_RS00540	COG1960	acyl-CoA dehydrogenase activity
GD578_RS00585	COG0271	Belongs to the BolA IbaG family
GD578_RS00595	COG1192	Involved in chromosome partitioning
GD578_RS00610	COG0586	Pfam SNARE associated Golgi protein
GD578_RS00620	COG4399	Belongs to the UPF0754 family
GD578_RS00620	COG4399	Belongs to the UPF0754 family
GD578_RS00625	COG0519	Catalyzes the synthesis of GMP from XMP
GD578_RS00625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GD578_RS00630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD578_RS00640	COG0735	belongs to the Fur family
GD578_RS00675	COG0281	malic enzyme
GD578_RS00685	COG2837	iron assimilation
GD578_RS00690	COG1280	lysine exporter protein (LysE YggA)
GD578_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GD578_RS00700	COG1121	(ABC) transporter
GD578_RS00755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GD578_RS00765	COG0386	Belongs to the glutathione peroxidase family
GD578_RS00780	COG1309	transcriptional regulator
GD578_RS00785	COG0697	spore germination
GD578_RS00795	COG0758	DNA mediated transformation
GD578_RS00830	COG1309	transcriptional regulator
GD578_RS00865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GD578_RS00880	COG0655	NAD(P)H dehydrogenase (quinone) activity
GD578_RS00915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GD578_RS00925	COG2814	Major facilitator Superfamily
GD578_RS00935	COG1253	flavin adenine dinucleotide binding
GD578_RS00940	COG3012	SEC-C Motif Domain Protein
GD578_RS00945	COG2860	membrane
GD578_RS00950	COG0477	Major facilitator Superfamily
GD578_RS00960	COG0318	PFAM AMP-dependent synthetase and ligase
GD578_RS00975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GD578_RS00990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GD578_RS00995	COG0235	Class ii aldolase
GD578_RS01000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD578_RS01005	COG0606	chelatase, subunit chli
GD578_RS01045	COG0589	response to stress
GD578_RS01050	COG0659	secondary active sulfate transmembrane transporter activity
GD578_RS01060	COG0606	chelatase, subunit chli
GD578_RS01070	COG0347	Belongs to the P(II) protein family
GD578_RS01075	COG0004	ammonium transporteR
GD578_RS01085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD578_RS01085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD578_RS01125	COG0795	lipopolysaccharide-transporting ATPase activity
GD578_RS01130	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GD578_RS01135	COG0793	Belongs to the peptidase S41A family
GD578_RS01150	COG2197	response regulator
GD578_RS01160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GD578_RS01170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GD578_RS01175	COG4974	Belongs to the 'phage' integrase family
GD578_RS01200	COG0772	Belongs to the SEDS family
GD578_RS01205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GD578_RS01210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GD578_RS01215	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GD578_RS01220	COG0494	nUDIX hydrolase
GD578_RS01240	COG0697	spore germination
GD578_RS01245	COG1538	Outer membrane efflux protein
GD578_RS01265	COG3275	phosphorelay sensor kinase activity
GD578_RS01275	COG0181	hydroxymethylbilane synthase activity
GD578_RS01320	COG1716	ATPase activity
GD578_RS01325	COG0546	phosphoglycolate phosphatase activity
GD578_RS01420	COG0596	Alpha beta hydrolase
GD578_RS01425	COG2056	Na+-H+ antiporter family
GD578_RS01445	COG0326	Molecular chaperone. Has ATPase activity
GD578_RS01460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GD578_RS01475	COG3545	Serine hydrolase
GD578_RS01520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GD578_RS01525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GD578_RS01525	COG2169	Transcriptional regulator
GD578_RS01540	COG1289	transmembrane transporter activity
GD578_RS01555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GD578_RS01565	COG0497	DNA recombination
GD578_RS01580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GD578_RS01590	COG0237	dephospho-CoA kinase activity
GD578_RS01640	COG0195	Participates in both transcription termination and antitermination
GD578_RS01650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GD578_RS01655	COG1320	monovalent cation:proton antiporter activity
GD578_RS01660	COG2212	antiporter activity
GD578_RS01665	COG1863	multisubunit Na H antiporter MnhE subunit
GD578_RS01670	COG0651	ATP synthesis coupled electron transport
GD578_RS01675	COG1006	Multisubunit Na H antiporter MnhC subunit
GD578_RS01680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GD578_RS01680	COG2111	Na H antiporter
GD578_RS01695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GD578_RS01705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GD578_RS01715	COG2226	methyltransferase
GD578_RS01740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GD578_RS01745	COG1074	ATP-dependent DNA helicase activity
GD578_RS01750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD578_RS01755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GD578_RS01765	COG1185	polyribonucleotide nucleotidyltransferase activity
GD578_RS01770	COG0598	Magnesium transport protein CorA
GD578_RS01775	COG0789	Transcriptional regulator
GD578_RS01780	COG0484	heat shock protein binding
GD578_RS01790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GD578_RS01795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GD578_RS01795	COG0475	glutathione-regulated potassium exporter activity
GD578_RS01800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GD578_RS01825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD578_RS01835	COG4535	Mg2 and Co2 transporter CorC
GD578_RS01850	COG0644	oxidoreductase
GD578_RS01850	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GD578_RS01860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GD578_RS01875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD578_RS01880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GD578_RS01890	COG0493	'glutamate synthase
GD578_RS01890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GD578_RS01920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GD578_RS01935	COG0534	Mate efflux family protein
GD578_RS01945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GD578_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS01955	COG0583	DNA-binding transcription factor activity
GD578_RS01970	COG0318	PFAM AMP-dependent synthetase and ligase
GD578_RS01975	COG1530	ribonuclease E activity
GD578_RS01990	COG2378	regulation of single-species biofilm formation
GD578_RS01995	COG0625	glutathione transferase activity
GD578_RS02005	COG0583	DNA-binding transcription factor activity
GD578_RS02050	COG0583	DNA-binding transcription factor activity
GD578_RS02075	COG0473	3-isopropylmalate dehydrogenase activity
GD578_RS02130	COG1301	dicarboxylic acid transport
GD578_RS02140	COG1560	Kdo2-lipid A biosynthetic process
GD578_RS02145	COG1280	lysine exporter protein (LysE YggA)
GD578_RS02155	COG0488	(ABC) transporter
GD578_RS02160	COG2900	Belongs to the SlyX family
GD578_RS02170	COG1733	regulation of RNA biosynthetic process
GD578_RS02195	COG0210	DNA helicase
GD578_RS02200	COG0724	RNA recognition motif
GD578_RS02220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GD578_RS02220	COG4651	solute:proton antiporter activity
GD578_RS02245	COG0788	formyltetrahydrofolate deformylase activity
GD578_RS02350	COG2813	Specifically methylates the guanine in position
GD578_RS02350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GD578_RS02360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GD578_RS02370	COG4774	siderophore transport
GD578_RS02380	COG0740	serine-type endopeptidase activity
GD578_RS02400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GD578_RS02400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GD578_RS02405	COG0857	belongs to the CobB CobQ family
GD578_RS02405	COG0280	phosphate acetyltransferase
GD578_RS02410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GD578_RS02420	COG0800	Aldolase
GD578_RS02430	COG3265	gluconokinase activity
GD578_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS02445	COG2267	carboxylic ester hydrolase activity
GD578_RS02460	COG0793	Belongs to the peptidase S41A family
GD578_RS02495	COG1426	Protein conserved in bacteria
GD578_RS02515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GD578_RS02535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GD578_RS02545	COG1162	GTPase activity
GD578_RS02550	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GD578_RS02565	COG1538	Outer membrane efflux protein
GD578_RS02570	COG0577	efflux transmembrane transporter activity
GD578_RS02570	COG1136	(ABC) transporter
GD578_RS02575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD578_RS02600	COG0028	Belongs to the TPP enzyme family
GD578_RS02605	COG0440	acetolactate synthase activity
GD578_RS02775	COG4221	oxidoreductase activity
GD578_RS02780	COG0583	DNA-binding transcription factor activity
GD578_RS02785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GD578_RS02805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GD578_RS02815	COG1979	alcohol dehydrogenase
GD578_RS02835	COG1309	transcriptional regulator
GD578_RS02840	COG2130	NADP-dependent
GD578_RS02865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GD578_RS02880	COG0084	hydrolase, TatD family'
GD578_RS02890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GD578_RS02910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GD578_RS02990	COG2205	protein histidine kinase activity
GD578_RS03005	COG2132	Multicopper oxidase
GD578_RS03035	COG3293	Transposase
GD578_RS03075	COG0640	Transcriptional regulator
GD578_RS03085	COG0798	PFAM Bile acid sodium symporter
GD578_RS03090	COG0431	NADPH-dependent FMN reductase
GD578_RS03095	COG0492	ferredoxin-NADP+ reductase activity
GD578_RS03100	COG2072	flavoprotein involved in K transport
GD578_RS03125	COG2814	Major facilitator Superfamily
GD578_RS03135	COG0697	spore germination
GD578_RS03165	COG3622	Belongs to the hyi family
GD578_RS03170	COG2084	Dehydrogenase
GD578_RS03175	COG1024	Enoyl-CoA hydratase
GD578_RS03180	COG5002	protein histidine kinase activity
GD578_RS03180	COG2205	protein histidine kinase activity
GD578_RS03180	COG0784	Response regulator, receiver
GD578_RS03200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GD578_RS03210	COG3956	TIGRFAM MazG family protein
GD578_RS03215	COG1555	photosystem II stabilization
GD578_RS03220	COG0617	tRNA 3'-terminal CCA addition
GD578_RS03225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GD578_RS03245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GD578_RS03250	COG3028	Belongs to the UPF0307 family
GD578_RS03255	COG0318	PFAM AMP-dependent synthetase and ligase
GD578_RS03270	COG0625	glutathione transferase activity
GD578_RS03275	COG1238	metal cluster binding
GD578_RS03285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GD578_RS03315	COG0072	phenylalanine-tRNA ligase activity
GD578_RS03345	COG0248	Ppx GppA phosphatase
GD578_RS03355	COG0037	tRNA processing
GD578_RS03375	COG3328	transposase activity
GD578_RS03400	COG1764	response to oxidative stress
GD578_RS03405	COG1846	Transcriptional regulator
GD578_RS03415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GD578_RS03475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GD578_RS03480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GD578_RS03485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GD578_RS03495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GD578_RS03545	COG1214	PFAM Peptidase M22, glycoprotease
GD578_RS03570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GD578_RS03575	COG0561	phosphatase activity
GD578_RS03585	COG2132	Multicopper oxidase
GD578_RS03605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GD578_RS03610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GD578_RS03615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GD578_RS03645	COG4695	Portal protein
GD578_RS03695	COG0860	N-Acetylmuramoyl-L-alanine amidase
GD578_RS03695	COG3409	Peptidoglycan-binding domain 1 protein
GD578_RS03820	COG3646	Phage regulatory protein
GD578_RS03850	COG1122	ATPase activity
GD578_RS03880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GD578_RS03885	COG0582	viral genome integration into host DNA
GD578_RS03900	COG1063	alcohol dehydrogenase
GD578_RS03905	COG0583	DNA-binding transcription factor activity
GD578_RS03910	COG1960	acyl-CoA dehydrogenase activity
GD578_RS03915	COG2814	Major facilitator Superfamily
GD578_RS03920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GD578_RS03925	COG1309	transcriptional regulator
GD578_RS03940	COG1053	succinate dehydrogenase
GD578_RS03945	COG0583	DNA-binding transcription factor activity
GD578_RS03960	COG0583	DNA-binding transcription factor activity
GD578_RS03970	COG0583	DNA-binding transcription factor activity
GD578_RS03985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GD578_RS03990	COG1309	transcriptional regulator
GD578_RS03995	COG3328	transposase activity
GD578_RS04005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GD578_RS04055	COG3328	transposase activity
GD578_RS04090	COG0745	RESPONSE REGULATOR receiver
GD578_RS04105	COG3706	GGDEF domain
GD578_RS04130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GD578_RS04160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GD578_RS04165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GD578_RS04190	COG0583	DNA-binding transcription factor activity
GD578_RS04210	COG0668	transmembrane transport
GD578_RS04220	COG2081	HI0933 family
GD578_RS04225	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GD578_RS04260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD578_RS04260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD578_RS04270	COG0489	protein tyrosine kinase activity
GD578_RS04330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GD578_RS04345	COG0730	response to heat
GD578_RS04355	COG1196	nuclear chromosome segregation
GD578_RS04375	COG2223	nitrite transmembrane transporter activity
GD578_RS04380	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GD578_RS04385	COG1877	trehalose-phosphatase activity
GD578_RS04390	COG0596	Alpha beta hydrolase
GD578_RS04390	COG2226	methyltransferase
GD578_RS04390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GD578_RS04405	COG4106	trans-aconitate 2-methyltransferase activity
GD578_RS04420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GD578_RS04425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GD578_RS04430	COG0009	L-threonylcarbamoyladenylate synthase
GD578_RS04435	COG3101	peptidyl-lysine hydroxylation
GD578_RS04440	COG1399	metal-binding, possibly nucleic acid-binding protein
GD578_RS04465	COG1652	LysM domain
GD578_RS04470	COG0352	thiamine-phosphate diphosphorylase activity
GD578_RS04470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GD578_RS04470	COG0351	phosphomethylpyrimidine kinase
GD578_RS04480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GD578_RS04510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GD578_RS04540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GD578_RS04555	COG0358	DNA primase activity
GD578_RS04595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GD578_RS04625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GD578_RS04625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GD578_RS04645	COG1981	membrane
GD578_RS04660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GD578_RS04690	COG0456	acetyltransferase
GD578_RS04700	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GD578_RS04705	COG0492	ferredoxin-NADP+ reductase activity
GD578_RS04710	COG1674	ftsk spoiiie
GD578_RS04715	COG1280	lysine exporter protein (LysE YggA)
GD578_RS04730	COG2894	cell division
GD578_RS04745	COG0204	Acyl-transferase
GD578_RS04750	COG2885	chlorophyll binding
GD578_RS04755	COG0210	DNA helicase
GD578_RS04765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GD578_RS04780	COG0121	glutamine amidotransferase
GD578_RS04805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GD578_RS04810	COG0735	belongs to the Fur family
GD578_RS04830	COG1968	undecaprenyl-diphosphatase activity
GD578_RS04840	COG0420	3'-5' exonuclease activity
GD578_RS04860	COG1090	epimerase
GD578_RS04875	COG2050	protein possibly involved in aromatic compounds catabolism
GD578_RS04885	COG2814	Major facilitator Superfamily
GD578_RS04890	COG0405	Gamma-glutamyltransferase
GD578_RS04930	COG0531	amino acid
GD578_RS04935	COG2040	homocysteine
GD578_RS04960	COG1309	transcriptional regulator
GD578_RS04965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GD578_RS04970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GD578_RS04980	COG1607	acyl-coa hydrolase
GD578_RS04990	COG0523	cobalamin synthesis protein
GD578_RS05000	COG4681	YaeQ
GD578_RS05010	COG1649	PFAM Uncharacterised BCR, COG1649
GD578_RS05010	COG0726	polysaccharide deacetylase
GD578_RS05015	COG1215	transferase activity, transferring glycosyl groups
GD578_RS05025	COG1024	Enoyl-CoA hydratase
GD578_RS05070	COG0028	Belongs to the TPP enzyme family
GD578_RS05080	COG0477	Major facilitator Superfamily
GD578_RS05085	COG0242	peptide deformylase activity
GD578_RS05090	COG2066	Belongs to the glutaminase family
GD578_RS05120	COG0306	phosphate transporter
GD578_RS05140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GD578_RS05185	COG4181	ATPase activity
GD578_RS05190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GD578_RS05215	COG0583	DNA-binding transcription factor activity
GD578_RS05225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GD578_RS05230	COG1773	rubredoxin
GD578_RS05280	COG2851	Citrate transporter
GD578_RS05285	COG1253	flavin adenine dinucleotide binding
GD578_RS05305	COG3293	Transposase
GD578_RS05340	COG0804	urea catabolic process
GD578_RS05350	COG0830	nickel cation binding
GD578_RS05370	COG0742	ribosomal rna small subunit methyltransferase
GD578_RS05375	COG0768	penicillin binding
GD578_RS05400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GD578_RS05405	COG2878	Part of a membrane complex involved in electron transport
GD578_RS05410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GD578_RS05420	COG3384	dioxygenase
GD578_RS05465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GD578_RS05500	COG0006	proline dipeptidase activity
GD578_RS05505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GD578_RS05510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GD578_RS05530	COG1279	arginine transmembrane transporter activity
GD578_RS05535	COG0583	DNA-binding transcription factor activity
GD578_RS05580	COG0741	lytic transglycosylase activity
GD578_RS05580	COG1388	LysM domain
GD578_RS05580	COG0741	lytic transglycosylase activity
GD578_RS05580	COG1388	LysM domain
GD578_RS05590	COG4174	ABC transporter (Permease)
GD578_RS05595	COG4239	(ABC) transporter, permease
GD578_RS05600	COG4172	Belongs to the ABC transporter superfamily
GD578_RS05625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GD578_RS05635	COG5001	Diguanylate cyclase
GD578_RS05635	COG4251	negative regulation of phosphorylation
GD578_RS05635	COG3706	GGDEF domain
GD578_RS05635	COG2203	Gaf domain
GD578_RS05650	COG1902	pentaerythritol trinitrate reductase activity
GD578_RS05650	COG0446	pyridine nucleotide-disulphide oxidoreductase
GD578_RS05785	COG1113	amino acid transport
GD578_RS05795	COG0531	amino acid
GD578_RS05815	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS05835	COG1113	amino acid transport
GD578_RS05855	COG0697	spore germination
GD578_RS05875	COG1960	acyl-CoA dehydrogenase activity
GD578_RS05885	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS05890	COG1024	Enoyl-CoA hydratase
GD578_RS05895	COG2814	Major facilitator Superfamily
GD578_RS05910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GD578_RS05930	COG1944	ATP diphosphatase activity
GD578_RS05960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GD578_RS05965	COG2072	flavoprotein involved in K transport
GD578_RS05980	COG1309	transcriptional regulator
GD578_RS05985	COG1741	Belongs to the pirin family
GD578_RS06000	COG2072	flavoprotein involved in K transport
GD578_RS06010	COG2252	PERMEase
GD578_RS06015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GD578_RS06020	COG3038	cytochrome b561
GD578_RS06030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GD578_RS06040	COG0527	aspartate kinase activity
GD578_RS06085	COG5410	chromosome segregation
GD578_RS06165	COG1598	PFAM Uncharacterised protein family UPF0150
GD578_RS06265	COG2194	sulfuric ester hydrolase activity
GD578_RS06270	COG0582	viral genome integration into host DNA
GD578_RS06290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GD578_RS06305	COG0667	Aldo Keto reductase
GD578_RS06315	COG1765	OsmC-like protein
GD578_RS06330	COG0542	response to heat
GD578_RS06365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GD578_RS06365	COG2885	chlorophyll binding
GD578_RS06380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GD578_RS06400	COG3634	alkyl hydroperoxide reductase activity
GD578_RS06420	COG0450	alkyl hydroperoxide reductase
GD578_RS06425	COG1643	Atp-dependent helicase
GD578_RS06440	COG2814	Major facilitator Superfamily
GD578_RS06450	COG3135	benzoate transporter
GD578_RS06455	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS06460	COG0543	2 iron, 2 sulfur cluster binding
GD578_RS06460	COG0633	Ferredoxin
GD578_RS06465	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GD578_RS06470	COG4638	Rieske (2fe-2S)
GD578_RS06475	COG0583	DNA-binding transcription factor activity
GD578_RS06485	COG2871	sodium ion transport
GD578_RS06580	COG1570	exodeoxyribonuclease VII activity
GD578_RS06610	COG1280	lysine exporter protein (LysE YggA)
GD578_RS06900	COG0517	IMP dehydrogenase activity
GD578_RS06900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GD578_RS06905	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GD578_RS06915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GD578_RS06920	COG1137	ATPase activity
GD578_RS06925	COG1538	Outer membrane efflux protein
GD578_RS06955	COG4122	O-methyltransferase activity
GD578_RS06965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GD578_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS07000	COG1960	acyl-CoA dehydrogenase activity
GD578_RS07040	COG2814	Major facilitator Superfamily
GD578_RS07075	COG1522	sequence-specific DNA binding
GD578_RS07095	COG0626	cystathionine gamma-synthase activity
GD578_RS07105	COG1278	Cold shock
GD578_RS07110	COG0789	Transcriptional regulator
GD578_RS07125	COG1250	3-hydroxyacyl-CoA dehydrogenase
GD578_RS07205	COG3220	belongs to the UPF0276 family
GD578_RS07215	COG1595	DNA-templated transcription, initiation
GD578_RS07225	COG0583	DNA-binding transcription factor activity
GD578_RS07230	COG1914	H( )-stimulated, divalent metal cation uptake system
GD578_RS07250	COG4770	biotin carboxylase activity
GD578_RS07255	COG0038	chloride channel
GD578_RS07290	COG1063	alcohol dehydrogenase
GD578_RS07305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GD578_RS07315	COG0789	Transcriptional regulator
GD578_RS07325	COG1760	l-serine dehydratase
GD578_RS07330	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS07330	COG2030	dehydratase
GD578_RS07335	COG3396	Phenylacetate-CoA oxygenase
GD578_RS07340	COG3460	Phenylacetate-CoA oxygenase
GD578_RS07345	COG3396	Phenylacetate-CoA oxygenase
GD578_RS07350	COG2151	metal-sulfur cluster biosynthetic enzyme
GD578_RS07355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GD578_RS07360	COG1024	Enoyl-CoA hydratase
GD578_RS07365	COG1024	Enoyl-CoA hydratase
GD578_RS07370	COG1250	3-hydroxyacyl-CoA dehydrogenase
GD578_RS07375	COG0183	Belongs to the thiolase family
GD578_RS07380	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GD578_RS07385	COG3327	negative regulation of DNA-templated transcription, initiation
GD578_RS07395	COG2050	protein possibly involved in aromatic compounds catabolism
GD578_RS07400	COG0583	DNA-binding transcription factor activity
GD578_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS07425	COG1414	Transcriptional regulator
GD578_RS07430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GD578_RS07445	COG3842	ATPase activity
GD578_RS07460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GD578_RS07465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GD578_RS07470	COG2814	Major facilitator Superfamily
GD578_RS07475	COG1960	acyl-CoA dehydrogenase activity
GD578_RS07490	COG1024	Enoyl-CoA hydratase
GD578_RS07500	COG2814	Major facilitator Superfamily
GD578_RS07510	COG0183	Belongs to the thiolase family
GD578_RS07515	COG1250	3-hydroxyacyl-CoA dehydrogenase
GD578_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS07525	COG1024	Enoyl-CoA hydratase
GD578_RS07530	COG1960	acyl-CoA dehydrogenase activity
GD578_RS07535	COG2814	Major facilitator Superfamily
GD578_RS07540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GD578_RS07545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GD578_RS07555	COG2814	Major facilitator Superfamily
GD578_RS07565	COG1960	acyl-CoA dehydrogenase activity
GD578_RS07580	COG0583	DNA-binding transcription factor activity
GD578_RS07590	COG4770	biotin carboxylase activity
GD578_RS07595	COG1024	Enoyl-CoA hydratase
GD578_RS07600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GD578_RS07605	COG1960	acyl-CoA dehydrogenase activity
GD578_RS07610	COG1309	transcriptional regulator
GD578_RS07615	COG0318	PFAM AMP-dependent synthetase and ligase
GD578_RS07635	COG0583	DNA-binding transcription factor activity
GD578_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS07725	COG2205	protein histidine kinase activity
GD578_RS07725	COG0784	Response regulator, receiver
GD578_RS07770	COG0765	amino acid transport
GD578_RS07775	COG0765	amino acid transport
GD578_RS07780	COG1126	abc transporter atp-binding protein
GD578_RS07785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD578_RS07790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD578_RS07805	COG1280	lysine exporter protein (LysE YggA)
GD578_RS07810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GD578_RS07815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GD578_RS07820	COG1045	serine acetyltransferase
GD578_RS07840	COG0625	glutathione transferase activity
GD578_RS07845	COG0625	glutathione transferase activity
GD578_RS07850	COG0583	DNA-binding transcription factor activity
GD578_RS07860	COG1346	cytolysis
GD578_RS07880	COG2814	Major facilitator Superfamily
GD578_RS07890	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GD578_RS07895	COG3052	prosthetic group binding
GD578_RS07915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GD578_RS07935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD578_RS07945	COG1294	oxidase, subunit
GD578_RS07950	COG1271	oxidase subunit
GD578_RS07970	COG0477	Major facilitator Superfamily
GD578_RS07980	COG4521	taurine ABC transporter
GD578_RS07985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GD578_RS07990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD578_RS07995	COG2175	clavaminate synthase activity
GD578_RS08005	COG1953	Uracil, thiamine, allantoin
GD578_RS08015	COG0583	DNA-binding transcription factor activity
GD578_RS08025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GD578_RS08040	COG0640	Transcriptional regulator
GD578_RS08045	COG0798	PFAM Bile acid sodium symporter
GD578_RS08050	COG0583	DNA-binding transcription factor activity
GD578_RS08065	COG3634	alkyl hydroperoxide reductase activity
GD578_RS08100	COG1301	dicarboxylic acid transport
GD578_RS08105	COG0436	Aminotransferase
GD578_RS08115	COG0386	Belongs to the glutathione peroxidase family
GD578_RS08125	COG1280	lysine exporter protein (LysE YggA)
GD578_RS08155	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GD578_RS08180	COG0012	GTP binding
GD578_RS08185	COG2011	ABC-type metal ion transport system permease component
GD578_RS08190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GD578_RS08200	COG1464	Belongs to the NlpA lipoprotein family
GD578_RS08230	COG0765	amino acid transport
GD578_RS08235	COG0765	amino acid transport
GD578_RS08240	COG1126	abc transporter atp-binding protein
GD578_RS08250	COG1522	sequence-specific DNA binding
GD578_RS08315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GD578_RS08325	COG0697	spore germination
GD578_RS08360	COG3121	Chaperone
GD578_RS08365	COG3539	Fimbrial protein
GD578_RS08390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GD578_RS08390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GD578_RS08430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GD578_RS08440	COG2353	YceI-like domain
GD578_RS08450	COG3698	Phosphodiester glycosidase
GD578_RS08465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GD578_RS08470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GD578_RS08470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GD578_RS08470	COG0506	proline dehydrogenase activity
GD578_RS08480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GD578_RS08485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GD578_RS08505	COG1132	(ABC) transporter
GD578_RS08510	COG3122	Protein conserved in bacteria
GD578_RS08515	COG3619	membrane
GD578_RS08525	COG0640	Transcriptional regulator
GD578_RS08535	COG2850	peptidyl-arginine hydroxylation
GD578_RS08540	COG0424	maF-like protein
GD578_RS08560	COG0191	fructose-bisphosphate aldolase activity
GD578_RS08565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GD578_RS08580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GD578_RS08590	COG1192	Involved in chromosome partitioning
GD578_RS08595	COG1475	DNA binding
GD578_RS08600	COG0811	peptide transport
GD578_RS08610	COG1132	(ABC) transporter
GD578_RS08615	COG1663	tetraacyldisaccharide 4'-kinase activity
GD578_RS08635	COG0084	hydrolase, TatD family'
GD578_RS08700	COG0776	regulation of translation
GD578_RS08715	COG2431	L-lysine efflux transmembrane transporter activity
GD578_RS08730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GD578_RS08735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GD578_RS08760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GD578_RS08785	COG0339	signal peptide processing
GD578_RS08790	COG0601	transmembrane transport
GD578_RS08795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GD578_RS08800	COG4172	Belongs to the ABC transporter superfamily
GD578_RS08830	COG0702	epimerase
GD578_RS08835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GD578_RS08855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GD578_RS08885	COG0316	Belongs to the HesB IscA family
GD578_RS08890	COG0822	iron-sulfur transferase activity
GD578_RS08915	COG0776	regulation of translation
GD578_RS08920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GD578_RS08925	COG2207	Transcriptional regulator
GD578_RS08930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD578_RS08935	COG1960	acyl-CoA dehydrogenase activity
GD578_RS08940	COG1960	acyl-CoA dehydrogenase activity
GD578_RS08955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GD578_RS08975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GD578_RS08980	COG0406	alpha-ribazole phosphatase activity
GD578_RS08995	COG4772	TonB-dependent receptor
GD578_RS09005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GD578_RS09010	COG0730	response to heat
GD578_RS09030	COG4773	Receptor
GD578_RS09035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GD578_RS09050	COG1131	(ABC) transporter
GD578_RS09055	COG0842	Transport permease protein
GD578_RS09060	COG0842	Transport permease protein
GD578_RS09115	COG2226	methyltransferase
GD578_RS09140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GD578_RS09175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GD578_RS09185	COG0133	tryptophan synthase activity
GD578_RS09215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GD578_RS09220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GD578_RS09225	COG0022	dehydrogenase e1 component
GD578_RS09230	COG0508	dehydrogenase complex catalyzes the overall conversion of
GD578_RS09235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD578_RS09245	COG1063	alcohol dehydrogenase
GD578_RS09250	COG3781	membrane
GD578_RS09260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD578_RS09260	COG3453	Protein conserved in bacteria
GD578_RS09270	COG0730	response to heat
GD578_RS09285	COG2207	Transcriptional regulator
GD578_RS09285	COG3708	Transcriptional regulator
GD578_RS09295	COG2188	Transcriptional regulator
GD578_RS09310	COG4521	taurine ABC transporter
GD578_RS09315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD578_RS09335	COG0477	Major facilitator Superfamily
GD578_RS09345	COG1027	Aspartate ammonia-lyase
GD578_RS09360	COG0583	DNA-binding transcription factor activity
GD578_RS09365	COG0583	DNA-binding transcription factor activity
GD578_RS09370	COG0183	Belongs to the thiolase family
GD578_RS09375	COG2031	fatty acid transporter
GD578_RS09390	COG0583	DNA-binding transcription factor activity
GD578_RS09405	COG1309	transcriptional regulator
GD578_RS09435	COG2610	gluconate transmembrane transporter activity
GD578_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS09445	COG2207	Transcriptional regulator
GD578_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS09470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GD578_RS09485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GD578_RS09485	COG0543	2 iron, 2 sulfur cluster binding
GD578_RS09490	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GD578_RS09495	COG4638	Rieske (2fe-2S)
GD578_RS09505	COG0725	ABC transporter, periplasmic molybdate-binding protein
GD578_RS09510	COG4149	molybdate abc transporter
GD578_RS09515	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GD578_RS09545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GD578_RS09550	COG3251	PFAM MbtH domain protein
GD578_RS09555	COG2382	esterase
GD578_RS09560	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS09565	COG1169	isochorismate synthase
GD578_RS09570	COG1021	2,3-dihydroxybenzoate-AMP ligase
GD578_RS09575	COG1535	isochorismatase
GD578_RS09575	COG3433	isochorismatase activity
GD578_RS09580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD578_RS09585	COG4771	TonB-dependent receptor
GD578_RS09650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GD578_RS09665	COG0753	catalase activity
GD578_RS09680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GD578_RS09705	COG3539	Fimbrial protein
GD578_RS09715	COG1538	Outer membrane efflux protein
GD578_RS09720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD578_RS09725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD578_RS09730	COG0745	RESPONSE REGULATOR receiver
GD578_RS09735	COG2205	protein histidine kinase activity
GD578_RS09740	COG0583	DNA-binding transcription factor activity
GD578_RS09815	COG1309	transcriptional regulator
GD578_RS09825	COG1309	transcriptional regulator
GD578_RS09840	COG0789	Transcriptional regulator
GD578_RS09850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GD578_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS09895	COG2186	Transcriptional regulator
GD578_RS09905	COG0583	DNA-binding transcription factor activity
GD578_RS09910	COG4948	Mandelate Racemase Muconate Lactonizing
GD578_RS09915	COG4829	muconolactone delta-isomerase
GD578_RS09925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GD578_RS09930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GD578_RS09935	COG0183	Belongs to the thiolase family
GD578_RS09940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GD578_RS09945	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS09965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GD578_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS09985	COG4638	Rieske (2fe-2S)
GD578_RS10005	COG0154	amidase activity
GD578_RS10015	COG2814	Major facilitator Superfamily
GD578_RS10040	COG1960	acyl-CoA dehydrogenase activity
GD578_RS10045	COG0583	DNA-binding transcription factor activity
GD578_RS10050	COG1414	Transcriptional regulator
GD578_RS10065	COG2391	methyltransferase activity
GD578_RS10075	COG4993	Dehydrogenase
GD578_RS10080	COG3659	wide pore channel activity
GD578_RS10085	COG3420	alginic acid biosynthetic process
GD578_RS10090	COG0710	3-dehydroquinate dehydratase activity
GD578_RS10095	COG3485	protocatechuate 3,4-dioxygenase
GD578_RS10100	COG3485	protocatechuate 3,4-dioxygenase
GD578_RS10105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GD578_RS10110	COG2271	Major facilitator Superfamily
GD578_RS10115	COG0596	Alpha beta hydrolase
GD578_RS10120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GD578_RS10125	COG0183	Belongs to the thiolase family
GD578_RS10130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GD578_RS10135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GD578_RS10145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GD578_RS10155	COG2323	membrane
GD578_RS10195	COG1902	pentaerythritol trinitrate reductase activity
GD578_RS10195	COG0446	pyridine nucleotide-disulphide oxidoreductase
GD578_RS10210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GD578_RS10220	COG0542	response to heat
GD578_RS10225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GD578_RS10255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GD578_RS10260	COG0569	domain protein
GD578_RS10265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GD578_RS10280	COG4774	siderophore transport
GD578_RS10285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GD578_RS10295	COG1585	Membrane protein implicated in regulation of membrane protease activity
GD578_RS10310	COG1294	oxidase, subunit
GD578_RS10315	COG4890	Cyd operon protein YbgT
GD578_RS10330	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GD578_RS10340	COG0552	protein localization to endoplasmic reticulum
GD578_RS10365	COG0517	IMP dehydrogenase activity
GD578_RS10365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GD578_RS10370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GD578_RS10375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GD578_RS10385	COG0583	DNA-binding transcription factor activity
GD578_RS10390	COG0024	Methionine aminopeptidase
GD578_RS10420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GD578_RS10420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GD578_RS10425	COG1105	Belongs to the carbohydrate kinase PfkB family
GD578_RS10430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GD578_RS10430	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GD578_RS10430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GD578_RS10450	COG3300	MHYT domain
GD578_RS10450	COG5001	Diguanylate cyclase
GD578_RS10465	COG2135	peptidase activity
GD578_RS10470	COG0659	secondary active sulfate transmembrane transporter activity
GD578_RS10485	COG1113	amino acid transport
GD578_RS10495	COG1522	sequence-specific DNA binding
GD578_RS10515	COG1011	Hydrolase
GD578_RS10520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GD578_RS10530	COG2137	regulation of response to DNA damage stimulus
GD578_RS10545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GD578_RS10580	COG0575	Belongs to the CDS family
GD578_RS10585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GD578_RS10610	COG3852	Histidine kinase
GD578_RS10615	COG2204	response regulator
GD578_RS10670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GD578_RS10675	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GD578_RS10695	COG0697	spore germination
GD578_RS10700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD578_RS10710	COG0303	'Molybdopterin
GD578_RS10715	COG0315	cyclic pyranopterin monophosphate synthase activity
GD578_RS10715	COG0521	Mo-molybdopterin cofactor biosynthetic process
GD578_RS10720	COG0314	molybdopterin synthase activity
GD578_RS10730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GD578_RS10735	COG0243	molybdopterin cofactor binding
GD578_RS10745	COG0243	molybdopterin cofactor binding
GD578_RS10750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GD578_RS10755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GD578_RS10755	COG2146	nitrite reductase [NAD(P)H] activity
GD578_RS10765	COG0745	RESPONSE REGULATOR receiver
GD578_RS10770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD578_RS10770	COG1116	anion transmembrane transporter activity
GD578_RS10790	COG0511	ligase activity, forming carbon-carbon bonds
GD578_RS10795	COG0439	Biotin carboxylase
GD578_RS10805	COG2814	Major facilitator Superfamily
GD578_RS10840	COG0069	glutamate synthase activity
GD578_RS10870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GD578_RS10885	COG1335	isochorismatase
GD578_RS10895	COG1454	alcohol dehydrogenase
GD578_RS10900	COG0824	Thioesterase
GD578_RS10910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GD578_RS10935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GD578_RS10940	COG2030	dehydratase
GD578_RS10950	COG0183	Belongs to the thiolase family
GD578_RS10960	COG0583	DNA-binding transcription factor activity
GD578_RS10965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GD578_RS10975	COG1522	sequence-specific DNA binding
GD578_RS10980	COG3135	benzoate transporter
GD578_RS10990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GD578_RS11005	COG0589	response to stress
GD578_RS11010	COG0488	(ABC) transporter
GD578_RS11055	COG0668	transmembrane transport
GD578_RS11060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GD578_RS11065	COG2423	ornithine cyclodeaminase activity
GD578_RS11070	COG4264	IucA IucC family
GD578_RS11080	COG4264	IucA IucC family
GD578_RS11110	COG1605	Chorismate mutase
GD578_RS11165	COG0308	aminopeptidase N
GD578_RS11185	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GD578_RS11195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD578_RS11200	COG1454	alcohol dehydrogenase
GD578_RS11220	COG0531	amino acid
GD578_RS11225	COG4303	Ethanolamine ammonia lyase large subunit
GD578_RS11230	COG4302	ethanolamine ammonia-lyase activity
GD578_RS11235	COG0519	Catalyzes the synthesis of GMP from XMP
GD578_RS11235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GD578_RS11250	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GD578_RS11265	COG0697	spore germination
GD578_RS11270	COG1923	regulation of RNA biosynthetic process
GD578_RS11280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GD578_RS11285	COG0802	atpase or kinase
GD578_RS11305	COG1187	pseudouridine synthase activity
GD578_RS11320	COG0583	DNA-binding transcription factor activity
GD578_RS11330	COG2814	Major facilitator Superfamily
GD578_RS11335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GD578_RS11365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GD578_RS11435	COG0592	DNA-directed DNA polymerase activity
GD578_RS11650	COG1484	DNA-dependent DNA replication
GD578_RS11740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GD578_RS11780	COG0729	surface antigen
GD578_RS11800	COG0174	glutamine synthetase
GD578_RS11805	COG0745	RESPONSE REGULATOR receiver
GD578_RS11810	COG2205	protein histidine kinase activity
GD578_RS11820	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GD578_RS11825	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GD578_RS11850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GD578_RS11855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GD578_RS11860	COG1960	acyl-CoA dehydrogenase activity
GD578_RS11875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD578_RS11880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD578_RS11905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GD578_RS11915	COG3658	cytochrome
GD578_RS11920	COG1215	transferase activity, transferring glycosyl groups
GD578_RS11925	COG0726	polysaccharide deacetylase
GD578_RS11925	COG1649	PFAM Uncharacterised BCR, COG1649
GD578_RS11955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GD578_RS11965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GD578_RS11990	COG0305	Participates in initiation and elongation during chromosome replication
GD578_RS11995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GD578_RS12005	COG1305	Transglutaminase-like
GD578_RS12015	COG2308	Evidence 4 Homologs of previously reported genes of
GD578_RS12045	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GD578_RS12050	COG0138	bifunctional purine biosynthesis protein purh
GD578_RS12055	COG0151	Belongs to the GarS family
GD578_RS12065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GD578_RS12070	COG2011	ABC-type metal ion transport system permease component
GD578_RS12075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD578_RS12085	COG1301	dicarboxylic acid transport
GD578_RS12130	COG0745	RESPONSE REGULATOR receiver
GD578_RS12140	COG0642	Histidine kinase
GD578_RS12145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GD578_RS12155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GD578_RS12180	COG5002	protein histidine kinase activity
GD578_RS12195	COG2351	hydroxyisourate hydrolase activity
GD578_RS12205	COG3008	intermembrane lipid transfer
GD578_RS12205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GD578_RS12210	COG2995	paraquat-inducible protein a
GD578_RS12225	COG2985	domain, Protein
GD578_RS12255	COG2207	Transcriptional regulator
GD578_RS12310	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS12315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GD578_RS12325	COG2186	Transcriptional regulator
GD578_RS12335	COG0475	glutathione-regulated potassium exporter activity
GD578_RS12335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GD578_RS12340	COG0786	glutamate:sodium symporter activity
GD578_RS12350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD578_RS12360	COG0596	Alpha beta hydrolase
GD578_RS12375	COG0583	DNA-binding transcription factor activity
GD578_RS12380	COG1335	isochorismatase
GD578_RS12415	COG3243	poly(R)-hydroxyalkanoic acid synthase
GD578_RS12430	COG3111	PFAM Bacterial OB fold (BOF) protein
GD578_RS12440	COG2226	methyltransferase
GD578_RS12520	COG3210	domain, Protein
GD578_RS12520	COG3210	domain, Protein
GD578_RS12550	COG2815	serine threonine protein kinase
GD578_RS12550	COG0515	serine threonine protein kinase
GD578_RS12580	COG1610	YqeY-like protein
GD578_RS12610	COG1286	toxin biosynthetic process
GD578_RS12640	COG0778	Nitroreductase
GD578_RS12650	COG0513	Belongs to the DEAD box helicase family
GD578_RS12670	COG2363	Small membrane protein
GD578_RS12695	COG1234	tRNA 3'-trailer cleavage
GD578_RS12700	COG2195	Cleaves the N-terminal amino acid of tripeptides
GD578_RS12705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GD578_RS12715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GD578_RS12740	COG1301	dicarboxylic acid transport
GD578_RS12745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GD578_RS12750	COG3139	Protein of unknown function (DUF1315)
GD578_RS12755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GD578_RS12760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD578_RS12770	COG0494	nUDIX hydrolase
GD578_RS12780	COG0642	Histidine kinase
GD578_RS12790	COG3111	PFAM Bacterial OB fold (BOF) protein
GD578_RS12795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GD578_RS12805	COG1720	tRNA m6t6A37 methyltransferase activity
GD578_RS12815	COG0384	phenazine biosynthesis protein PhzF
GD578_RS12820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD578_RS12825	COG0826	peptidase U32
GD578_RS12830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GD578_RS12840	COG4598	ABC transporter
GD578_RS12845	COG4160	amino acid transport
GD578_RS12850	COG4215	(ABC) transporter
GD578_RS12865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD578_RS13035	COG3646	Phage regulatory protein
GD578_RS13110	COG2357	RelA SpoT domain protein
GD578_RS13165	COG0305	Participates in initiation and elongation during chromosome replication
GD578_RS13250	COG0582	viral genome integration into host DNA
GD578_RS13255	COG1131	(ABC) transporter
GD578_RS13260	COG0842	Transport permease protein
GD578_RS13275	COG0772	Belongs to the SEDS family
GD578_RS13280	COG2951	lytic endotransglycosylase activity
GD578_RS13305	COG2207	Transcriptional regulator
GD578_RS13320	COG0052	Belongs to the universal ribosomal protein uS2 family
GD578_RS13325	COG0024	Methionine aminopeptidase
GD578_RS13335	COG2223	nitrite transmembrane transporter activity
GD578_RS13345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD578_RS13350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GD578_RS13355	COG1960	acyl-CoA dehydrogenase activity
GD578_RS13370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GD578_RS13375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GD578_RS13380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GD578_RS13400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GD578_RS13405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GD578_RS13410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GD578_RS13445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GD578_RS13455	COG0174	glutamine synthetase
GD578_RS13475	COG1876	peptidase activity
GD578_RS13500	COG0512	Glutamine amidotransferase of anthranilate synthase
GD578_RS13525	COG2840	Smr protein MutS2
GD578_RS13535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GD578_RS13545	COG0302	gtp cyclohydrolase
GD578_RS13565	COG3739	integral membrane protein
GD578_RS13580	COG1741	Belongs to the pirin family
GD578_RS13585	COG2964	Protein conserved in bacteria
GD578_RS13615	COG2879	small protein
GD578_RS13620	COG1966	Carbon starvation protein
GD578_RS13625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GD578_RS13640	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GD578_RS13665	COG1067	ATP-dependent peptidase activity
GD578_RS13670	COG0583	DNA-binding transcription factor activity
GD578_RS13695	COG1686	Belongs to the peptidase S11 family
GD578_RS13700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GD578_RS13725	COG3647	Membrane
GD578_RS13740	COG0616	signal peptide processing
GD578_RS13745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GD578_RS13755	COG0573	inorganic phosphate transmembrane transporter activity
GD578_RS13760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GD578_RS13765	COG1113	amino acid transport
GD578_RS13770	COG3961	Belongs to the TPP enzyme family
GD578_RS13775	COG1522	sequence-specific DNA binding
GD578_RS13785	COG0076	glutamate decarboxylase activity
GD578_RS13790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GD578_RS13815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GD578_RS13850	COG0352	thiamine-phosphate diphosphorylase activity
GD578_RS13875	COG0612	Peptidase, M16
GD578_RS13885	COG1823	symporter activity
GD578_RS13890	COG0583	DNA-binding transcription factor activity
GD578_RS13895	COG0477	Major facilitator Superfamily
GD578_RS13935	COG1686	Belongs to the peptidase S11 family
GD578_RS13940	COG1252	NADH dehydrogenase
GD578_RS13950	COG0415	Belongs to the DNA photolyase family
GD578_RS13965	COG1215	transferase activity, transferring glycosyl groups
GD578_RS13995	COG2070	2-Nitropropane dioxygenase
GD578_RS14050	COG0556	nucleotide-excision repair
GD578_RS14070	COG0436	Aminotransferase
GD578_RS14100	COG4221	oxidoreductase activity
GD578_RS14110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GD578_RS14115	COG1381	Involved in DNA repair and RecF pathway recombination
GD578_RS14125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GD578_RS14140	COG0681	Belongs to the peptidase S26 family
GD578_RS14145	COG0481	GTPase activity
GD578_RS14155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GD578_RS14175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GD578_RS14180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GD578_RS14185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GD578_RS14195	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GD578_RS14200	COG4208	sulfate ABC transporter
GD578_RS14205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GD578_RS14210	COG0583	DNA-binding transcription factor activity
GD578_RS14215	COG4625	pathogenesis
GD578_RS14225	COG0602	queuosine metabolic process
GD578_RS14230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GD578_RS14245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GD578_RS14260	COG1056	cytidyltransferase-related domain
GD578_RS14260	COG1051	belongs to the nudix hydrolase family
GD578_RS14265	COG1024	Enoyl-CoA hydratase
GD578_RS14270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GD578_RS14275	COG2814	Major facilitator Superfamily
GD578_RS14280	COG0047	phosphoribosylformylglycinamidine synthase activity
GD578_RS14280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GD578_RS14300	COG1473	amidohydrolase
GD578_RS14305	COG0824	Thioesterase
GD578_RS14325	COG0823	Involved in the tonB-independent uptake of proteins
GD578_RS14345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GD578_RS14380	COG0628	permease
GD578_RS14390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GD578_RS14395	COG0596	Alpha beta hydrolase
GD578_RS14400	COG0616	signal peptide processing
GD578_RS14400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GD578_RS14415	COG1136	(ABC) transporter
GD578_RS14420	COG4591	ABC-type transport system involved in lipoprotein release permease component
GD578_RS14450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD578_RS14470	COG0463	Glycosyl transferase, family 2
GD578_RS14480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GD578_RS14490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD578_RS14510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GD578_RS14515	COG1280	lysine exporter protein (LysE YggA)
GD578_RS14525	COG0019	diaminopimelate decarboxylase activity
GD578_RS14535	COG1113	amino acid transport
GD578_RS14540	COG1113	amino acid transport
GD578_RS14555	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GD578_RS14570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GD578_RS14575	COG0243	molybdopterin cofactor binding
GD578_RS14580	COG1929	Belongs to the glycerate kinase type-1 family
GD578_RS14590	COG0300	oxidoreductase activity
GD578_RS14595	COG0778	Nitroreductase
GD578_RS14615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD578_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS14635	COG0596	Alpha beta hydrolase
GD578_RS14635	COG0508	dehydrogenase complex catalyzes the overall conversion of
GD578_RS14640	COG1902	pentaerythritol trinitrate reductase activity
GD578_RS14645	COG1309	transcriptional regulator
GD578_RS14670	COG3811	Belongs to the UPF0386 family
GD578_RS14690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GD578_RS14705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GD578_RS14725	COG0741	lytic transglycosylase activity
GD578_RS14745	COG0584	glycerophosphoryl diester phosphodiesterase
GD578_RS14750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD578_RS14760	COG0582	viral genome integration into host DNA
GD578_RS14765	COG1074	ATP-dependent DNA helicase activity
GD578_RS14790	COG2814	Major facilitator Superfamily
GD578_RS14870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GD578_RS14885	COG0753	catalase activity
GD578_RS14890	COG1250	3-hydroxyacyl-CoA dehydrogenase
GD578_RS14930	COG0789	Transcriptional regulator
GD578_RS14975	COG0789	Transcriptional regulator
GD578_RS15000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GD578_RS15005	COG1597	lipid kinase activity
GD578_RS15020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GD578_RS15025	COG0477	Major facilitator Superfamily
GD578_RS15075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GD578_RS15080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GD578_RS15105	COG0505	Belongs to the CarA family
GD578_RS15120	COG1309	transcriptional regulator
GD578_RS15125	COG0251	oxidation-reduction process
GD578_RS15135	COG0589	response to stress
GD578_RS15155	COG2843	Capsule synthesis protein
GD578_RS15175	COG2321	neutral zinc metallopeptidase
GD578_RS15180	COG2354	Protein conserved in bacteria
GD578_RS15200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD578_RS15225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GD578_RS15230	COG1053	succinate dehydrogenase
GD578_RS15235	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GD578_RS15240	COG2009	succinate dehydrogenase
GD578_RS15280	COG2921	Belongs to the UPF0250 family
GD578_RS15285	COG0321	lipoyl(octanoyl) transferase activity
GD578_RS15300	COG0531	amino acid
GD578_RS15310	COG1733	regulation of RNA biosynthetic process
GD578_RS15315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GD578_RS15320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GD578_RS15320	COG1648	precorrin-2 dehydrogenase activity
GD578_RS15335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GD578_RS15365	COG0671	phosphoesterase, PA-phosphatase related
GD578_RS15370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD578_RS15380	COG1538	Outer membrane efflux protein
GD578_RS15385	COG0393	Putative heavy-metal-binding
GD578_RS15390	COG0393	Putative heavy-metal-binding
GD578_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
GD578_RS15410	COG0525	valine-tRNA ligase activity
GD578_RS15430	COG0583	DNA-binding transcription factor activity
GD578_RS15435	COG0004	ammonium transporteR
GD578_RS15445	COG0642	Histidine kinase
GD578_RS15450	COG0745	RESPONSE REGULATOR receiver
GD578_RS15455	COG2194	sulfuric ester hydrolase activity
GD578_RS15475	COG1752	Esterase of the alpha-beta hydrolase superfamily
GD578_RS15490	COG2315	Protein conserved in bacteria
GD578_RS15495	COG0142	geranyltranstransferase activity
GD578_RS15500	COG2828	Protein conserved in bacteria
GD578_RS15505	COG1113	amino acid transport
GD578_RS15510	COG2816	NAD+ diphosphatase activity
GD578_RS15515	COG3046	protein related to deoxyribodipyrimidine photolyase
GD578_RS15545	COG2207	Transcriptional regulator
GD578_RS15570	COG2249	NAD(P)H dehydrogenase (quinone) activity
GD578_RS15590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GD578_RS15600	COG1530	ribonuclease E activity
GD578_RS15605	COG0424	maF-like protein
GD578_RS15610	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GD578_RS15615	COG1792	Involved in formation and maintenance of cell shape
GD578_RS15620	COG1077	Cell shape determining protein MreB Mrl
GD578_RS15625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GD578_RS15635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GD578_RS15675	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GD578_RS15680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GD578_RS15685	COG1752	Esterase of the alpha-beta hydrolase superfamily
GD578_RS15690	COG1115	amino acid carrier protein
GD578_RS15710	COG2814	Major facilitator Superfamily
GD578_RS15715	COG1289	transmembrane transporter activity
GD578_RS15725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GD578_RS15765	COG1376	ErfK ybiS ycfS ynhG family protein
GD578_RS15770	COG2832	Protein of unknown function (DUF454)
GD578_RS15800	COG0840	transmembrane signaling receptor activity
GD578_RS15840	COG3422	double-strand break repair
GD578_RS15845	COG2824	Alkylphosphonate utilization operon protein PhnA
GD578_RS15850	COG3189	MarR family transcriptional regulator
GD578_RS15860	COG0354	folic acid binding
GD578_RS15865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GD578_RS15875	COG0679	Auxin Efflux Carrier
GD578_RS15880	COG1902	pentaerythritol trinitrate reductase activity
GD578_RS15885	COG4772	TonB-dependent receptor
GD578_RS15890	COG2094	Belongs to the DNA glycosylase MPG family
GD578_RS15915	COG1217	gtp-binding protein TYPA
GD578_RS15920	COG2233	PERMEase
GD578_RS15930	COG0833	amino acid
GD578_RS15935	COG1690	Belongs to the RtcB family
GD578_RS15940	COG2885	chlorophyll binding
GD578_RS15940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GD578_RS15950	COG0183	Belongs to the thiolase family
GD578_RS15970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GD578_RS15990	COG2207	Transcriptional regulator
GD578_RS15995	COG0183	Belongs to the thiolase family
GD578_RS16015	COG2153	protein acetylation
GD578_RS16025	COG1272	protein, Hemolysin III
GD578_RS16030	COG0477	Major facilitator Superfamily
GD578_RS16045	COG0450	alkyl hydroperoxide reductase
GD578_RS16065	COG0285	dihydrofolate synthase activity
GD578_RS16120	COG2096	Adenosyltransferase
GD578_RS16140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GD578_RS16145	COG0745	RESPONSE REGULATOR receiver
GD578_RS16150	COG2205	protein histidine kinase activity
GD578_RS16160	COG1960	acyl-CoA dehydrogenase activity
GD578_RS16165	COG1960	acyl-CoA dehydrogenase activity
GD578_RS16210	COG0438	transferase activity, transferring glycosyl groups
GD578_RS16215	COG1216	Glycosyl transferase, family 2
GD578_RS16215	COG0463	Glycosyl transferase, family 2
GD578_RS16220	COG0438	transferase activity, transferring glycosyl groups
GD578_RS16230	COG0438	transferase activity, transferring glycosyl groups
GD578_RS16235	COG0726	polysaccharide deacetylase
GD578_RS16250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GD578_RS16255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD578_RS16255	COG2205	protein histidine kinase activity
GD578_RS16255	COG2198	Histidine kinase
GD578_RS16255	COG0784	Response regulator, receiver
GD578_RS16285	COG1862	Preprotein translocase
GD578_RS16295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GD578_RS16300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GD578_RS16310	COG3781	membrane
GD578_RS16315	COG0613	PHP domain protein
GD578_RS16325	COG2350	Protein conserved in bacteria
GD578_RS16360	COG1607	acyl-coa hydrolase
GD578_RS16420	COG2199	diguanylate cyclase activity
GD578_RS16430	COG1408	metallophosphoesterase
GD578_RS16435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GD578_RS16445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GD578_RS16465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GD578_RS16470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GD578_RS16475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GD578_RS16480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GD578_RS16485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GD578_RS16495	COG2969	positive regulation of protein catabolic process
GD578_RS16535	COG1960	acyl-CoA dehydrogenase activity
GD578_RS16540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GD578_RS16555	COG1309	transcriptional regulator
GD578_RS16560	COG1960	acyl-CoA dehydrogenase activity
GD578_RS16605	COG1183	phosphatidylcholine synthase activity
GD578_RS16610	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GD578_RS16640	COG1196	nuclear chromosome segregation
GD578_RS16640	COG0739	heme binding
GD578_RS16640	COG0741	lytic transglycosylase activity
GD578_RS16650	COG1702	phosphate starvation-inducible protein PhoH
GD578_RS16685	COG1295	ribonuclease BN
GD578_RS16695	COG2207	Transcriptional regulator
GD578_RS16700	COG0179	Fumarylacetoacetate (FAA) hydrolase
GD578_RS16745	COG0557	exoribonuclease II activity
GD578_RS16750	COG0339	signal peptide processing
GD578_RS16755	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GD578_RS16785	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GD578_RS16790	COG1960	acyl-CoA dehydrogenase activity
GD578_RS16925	COG0088	Forms part of the polypeptide exit tunnel
GD578_RS16930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GD578_RS16945	COG0626	cystathionine gamma-synthase activity
GD578_RS16950	COG0433	COG0433 Predicted ATPase
GD578_RS16955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GD578_RS16955	COG1017	nitric oxide dioxygenase activity
GD578_RS16960	COG1959	2 iron, 2 sulfur cluster binding
GD578_RS16975	COG1301	dicarboxylic acid transport
GD578_RS16980	COG1946	Acyl-CoA thioesterase
GD578_RS16985	COG2937	Belongs to the GPAT DAPAT family
GD578_RS17000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GD578_RS17005	COG1040	competence protein
GD578_RS17010	COG0494	nUDIX hydrolase
GD578_RS17020	COG0598	Magnesium transport protein CorA
GD578_RS17030	COG2854	intermembrane phospholipid transfer
GD578_RS17040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GD578_RS17045	COG1127	ABC transporter
GD578_RS17070	COG0408	coproporphyrinogen oxidase activity
GD578_RS17085	COG1960	acyl-CoA dehydrogenase activity
GD578_RS17095	COG1983	PspC domain protein
GD578_RS17100	COG0517	IMP dehydrogenase activity
GD578_RS17145	COG0583	DNA-binding transcription factor activity
GD578_RS17185	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS17195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GD578_RS17200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GD578_RS17205	COG0833	amino acid
GD578_RS17235	COG1192	Involved in chromosome partitioning
GD578_RS17240	COG0628	permease
GD578_RS17250	COG1289	transmembrane transporter activity
GD578_RS17265	COG2249	NAD(P)H dehydrogenase (quinone) activity
GD578_RS17270	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GD578_RS17285	COG0277	FAD linked oxidase domain protein
GD578_RS17290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GD578_RS17295	COG5006	permease, DMT superfamily
GD578_RS17300	COG5006	permease, DMT superfamily
GD578_RS17315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GD578_RS17320	COG5380	lipid catabolic process
GD578_RS17340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GD578_RS17355	COG4969	Belongs to the N-Me-Phe pilin family
GD578_RS17390	COG0194	GDP metabolic process
GD578_RS17405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GD578_RS17425	COG3307	-O-antigen
GD578_RS17450	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GD578_RS17455	COG1704	LemA family
GD578_RS17465	COG0493	'glutamate synthase
GD578_RS17470	COG0067	glutamate synthase
GD578_RS17470	COG0069	glutamate synthase activity
GD578_RS17470	COG0070	glutamate synthase
GD578_RS17520	COG2226	methyltransferase
GD578_RS17535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GD578_RS17540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GD578_RS17585	COG0833	amino acid
GD578_RS17665	COG0488	(ABC) transporter
GD578_RS17670	COG0028	Belongs to the TPP enzyme family
GD578_RS17675	COG2873	o-acetylhomoserine
GD578_RS17680	COG4221	oxidoreductase activity
GD578_RS17685	COG0659	secondary active sulfate transmembrane transporter activity
GD578_RS17710	COG0427	acetyl-CoA hydrolase
GD578_RS17740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GD578_RS17760	COG1132	(ABC) transporter
GD578_RS17785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GD578_RS17840	COG2207	Transcriptional regulator
GD578_RS17845	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GD578_RS17860	COG2249	NAD(P)H dehydrogenase (quinone) activity
GD578_RS17865	COG1733	regulation of RNA biosynthetic process
GD578_RS17905	COG0667	Aldo Keto reductase
GD578_RS17925	COG0583	DNA-binding transcription factor activity
GD578_RS17930	COG2814	Major facilitator Superfamily
GD578_RS17965	COG1335	isochorismatase
GD578_RS17975	COG1012	belongs to the aldehyde dehydrogenase family
GD578_RS17980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GD578_RS17990	COG1113	amino acid transport
GD578_RS18000	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GD578_RS18050	COG2814	Major facilitator Superfamily
GD578_RS18060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GD578_RS18060	COG0351	phosphomethylpyrimidine kinase
GD578_RS18060	COG0352	thiamine-phosphate diphosphorylase activity
GD578_RS18080	COG1309	transcriptional regulator
GD578_RS18100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GD578_RS18110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GD578_RS18115	COG3162	membrane
GD578_RS18120	COG2198	Histidine kinase
GD578_RS18120	COG0784	Response regulator, receiver
GD578_RS18120	COG2205	protein histidine kinase activity
GD578_RS18145	COG1522	sequence-specific DNA binding
GD578_RS18150	COG1335	isochorismatase
GD578_RS18155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GD578_RS18165	COG0668	transmembrane transport
GD578_RS18170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GD578_RS18175	COG1519	Transferase
GD578_RS18180	COG1902	pentaerythritol trinitrate reductase activity
GD578_RS18200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GD578_RS18225	COG0426	domain, Protein
GD578_RS18225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GD578_RS18230	COG2119	membrane
GD578_RS18240	COG0508	dehydrogenase complex catalyzes the overall conversion of
GD578_RS18250	COG4942	peptidase
GD578_RS18265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GD578_RS18275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GD578_RS18295	COG0189	ligase activity
GD578_RS18315	COG0708	Exodeoxyribonuclease III
GD578_RS18320	COG1393	Belongs to the ArsC family
GD578_RS18335	COG3706	GGDEF domain
GD578_RS18370	COG2351	hydroxyisourate hydrolase activity
GD578_RS18375	COG2233	PERMEase
GD578_RS18385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GD578_RS18395	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GD578_RS18405	COG3150	esterase
GD578_RS18460	COG3409	Peptidoglycan-binding domain 1 protein
GD578_RS18460	COG5632	N-Acetylmuramoyl-L-alanine amidase
GD578_RS18460	COG1388	LysM domain
GD578_RS18475	COG2918	glutathione biosynthetic process
GD578_RS18490	COG2733	membrane
GD578_RS18495	COG0436	Aminotransferase
GD578_RS18500	COG0534	Mate efflux family protein
GD578_RS18590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GD578_RS18595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GD578_RS18605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GD578_RS18620	COG1280	lysine exporter protein (LysE YggA)
GD578_RS18625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GD578_RS18640	COG0010	Belongs to the arginase family
GD578_RS18670	COG2188	Transcriptional regulator
GD578_RS18680	COG0523	cobalamin synthesis protein
GD578_RS18690	COG1113	amino acid transport
GD578_RS18700	COG0625	glutathione transferase activity
GD578_RS18720	COG1683	Conserved Protein
GD578_RS18725	COG0534	Mate efflux family protein
GD578_RS18730	COG0385	Bile acid
GD578_RS18735	COG1335	isochorismatase
GD578_RS18740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GD578_RS18760	COG2116	formate transmembrane transporter activity
GD578_RS18765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GD578_RS18770	COG2133	pyrroloquinoline quinone binding
GD578_RS18775	COG2983	Belongs to the UPF0260 family
GD578_RS18780	COG5487	UPF0391 membrane protein
GD578_RS18795	COG1194	a g-specific adenine glycosylase
GD578_RS18810	COG2818	Glycosylase
GD578_RS18815	COG1064	alcohol dehydrogenase
GD578_RS18820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD578_RS18835	COG0583	DNA-binding transcription factor activity
GD578_RS18840	COG0656	L-ascorbic acid biosynthetic process
GD578_RS18845	COG2814	Major facilitator Superfamily
GD578_RS18880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD578_RS18895	COG2233	PERMEase
GD578_RS18935	COG0733	neurotransmitter:sodium symporter activity
GD578_RS18975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GD578_RS18980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GD578_RS18985	COG0596	Alpha beta hydrolase
GD578_RS19010	COG0488	(ABC) transporter
GD578_RS19015	COG0586	Pfam SNARE associated Golgi protein
GD578_RS19025	COG0187	DNA topoisomerase II activity
GD578_RS19035	COG0592	DNA-directed DNA polymerase activity
GD578_RS19060	COG0706	membrane insertase activity
GD578_RS19075	COG1230	cation diffusion facilitator family transporter
GD578_RS19080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GD578_RS19095	COG0402	S-adenosylhomocysteine deaminase activity
GD578_RS19105	COG0754	glutathionylspermidine amidase activity
GD578_RS19115	COG0861	Integral membrane protein TerC family
GD578_RS19120	COG0671	phosphoesterase, PA-phosphatase related
GD578_RS19130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GD578_RS19145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GD578_RS19150	COG2951	lytic endotransglycosylase activity
GD578_RS19200	COG0657	acetylesterase activity
GD578_RS19205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GD578_RS19210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD578_RS19215	COG1538	Outer membrane efflux protein
GD578_RS19250	COG1660	Displays ATPase and GTPase activities
GD578_RS19310	COG0739	heme binding
GD578_RS19385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GD578_RS19490	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GD578_RS19495	COG3293	Transposase
GD578_RS19550	COG2826	transposase and inactivated derivatives, IS30 family
GD578_RS19570	COG0673	inositol 2-dehydrogenase activity
GD578_RS19575	COG1324	tolerance protein
GD578_RS19600	COG2826	transposase and inactivated derivatives, IS30 family
GD578_RS19675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GD578_RS19695	COG2184	nucleotidyltransferase activity
GD578_RS19705	COG4974	Belongs to the 'phage' integrase family
GD578_RS19795	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GD578_RS19800	COG0501	Belongs to the peptidase M48B family
GD578_RS19940	COG3657	addiction module killer protein
GD578_RS19945	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD578_RS19950	COG0659	secondary active sulfate transmembrane transporter activity
GD578_RS20010	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD578_RS20030	COG0488	(ABC) transporter
GD578_RS20035	COG3173	Aminoglycoside phosphotransferase
GD578_RS20050	COG2205	protein histidine kinase activity
GD578_RS20055	COG0745	RESPONSE REGULATOR receiver