locus-tag	class	description
FRD49_RS00010	COG0592	DNA-directed DNA polymerase activity
FRD49_RS00020	COG0187	DNA topoisomerase II activity
FRD49_RS00030	COG0586	Pfam SNARE associated Golgi protein
FRD49_RS00035	COG0488	(ABC) transporter
FRD49_RS00060	COG0596	Alpha beta hydrolase
FRD49_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FRD49_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRD49_RS00115	COG0733	neurotransmitter:sodium symporter activity
FRD49_RS00155	COG2233	PERMEase
FRD49_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_RS00205	COG2814	Major facilitator Superfamily
FRD49_RS00210	COG0656	L-ascorbic acid biosynthetic process
FRD49_RS00215	COG0583	DNA-binding transcription factor activity
FRD49_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_RS00230	COG1064	alcohol dehydrogenase
FRD49_RS00235	COG2818	Glycosylase
FRD49_RS00250	COG1194	a g-specific adenine glycosylase
FRD49_RS00265	COG5487	UPF0391 membrane protein
FRD49_RS00270	COG2983	Belongs to the UPF0260 family
FRD49_RS00275	COG2133	pyrroloquinoline quinone binding
FRD49_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FRD49_RS00285	COG2116	formate transmembrane transporter activity
FRD49_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRD49_RS00310	COG1335	isochorismatase
FRD49_RS00315	COG0385	Bile acid
FRD49_RS00320	COG0534	Mate efflux family protein
FRD49_RS00325	COG1683	Conserved Protein
FRD49_RS00345	COG0625	glutathione transferase activity
FRD49_RS00355	COG1113	amino acid transport
FRD49_RS00365	COG0523	cobalamin synthesis protein
FRD49_RS00375	COG2188	Transcriptional regulator
FRD49_RS00405	COG0010	Belongs to the arginase family
FRD49_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRD49_RS00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRD49_RS00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRD49_RS00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FRD49_RS00545	COG0534	Mate efflux family protein
FRD49_RS00550	COG0436	Aminotransferase
FRD49_RS00555	COG2733	membrane
FRD49_RS00570	COG2918	glutathione biosynthetic process
FRD49_RS00645	COG3150	esterase
FRD49_RS00655	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FRD49_RS00665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_RS00675	COG2233	PERMEase
FRD49_RS00680	COG2351	hydroxyisourate hydrolase activity
FRD49_RS00715	COG3706	GGDEF domain
FRD49_RS00730	COG1393	Belongs to the ArsC family
FRD49_RS00735	COG0708	Exodeoxyribonuclease III
FRD49_RS00755	COG0189	ligase activity
FRD49_RS00780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRD49_RS00790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRD49_RS00805	COG4942	peptidase
FRD49_RS00815	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRD49_RS00825	COG2119	membrane
FRD49_RS00830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_RS00830	COG0426	domain, Protein
FRD49_RS00855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRD49_RS00875	COG1902	pentaerythritol trinitrate reductase activity
FRD49_RS00880	COG1519	Transferase
FRD49_RS00885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRD49_RS00890	COG0668	transmembrane transport
FRD49_RS00900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRD49_RS00905	COG1335	isochorismatase
FRD49_RS00910	COG1522	sequence-specific DNA binding
FRD49_RS00935	COG2205	protein histidine kinase activity
FRD49_RS00935	COG2198	Histidine kinase
FRD49_RS00935	COG0784	Response regulator, receiver
FRD49_RS00940	COG3162	membrane
FRD49_RS00945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRD49_RS00955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRD49_RS00975	COG1309	transcriptional regulator
FRD49_RS00995	COG0300	oxidoreductase activity
FRD49_RS01005	COG0351	phosphomethylpyrimidine kinase
FRD49_RS01005	COG0352	thiamine-phosphate diphosphorylase activity
FRD49_RS01005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRD49_RS01015	COG2814	Major facilitator Superfamily
FRD49_RS01055	COG1196	nuclear chromosome segregation
FRD49_RS01070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRD49_RS01110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRD49_RS01140	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FRD49_RS01150	COG1113	amino acid transport
FRD49_RS01160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FRD49_RS01165	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS01175	COG1335	isochorismatase
FRD49_RS01210	COG2814	Major facilitator Superfamily
FRD49_RS01215	COG0583	DNA-binding transcription factor activity
FRD49_RS01235	COG0667	Aldo Keto reductase
FRD49_RS01280	COG1733	regulation of RNA biosynthetic process
FRD49_RS01290	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_RS01315	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FRD49_RS01320	COG2207	Transcriptional regulator
FRD49_RS01375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FRD49_RS01440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FRD49_RS01470	COG0427	acetyl-CoA hydrolase
FRD49_RS01495	COG0659	secondary active sulfate transmembrane transporter activity
FRD49_RS01500	COG4221	oxidoreductase activity
FRD49_RS01505	COG2873	o-acetylhomoserine
FRD49_RS01510	COG0028	Belongs to the TPP enzyme family
FRD49_RS01515	COG0488	(ABC) transporter
FRD49_RS01580	COG0833	amino acid
FRD49_RS01625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRD49_RS01630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRD49_RS01645	COG2226	methyltransferase
FRD49_RS01695	COG0069	glutamate synthase activity
FRD49_RS01695	COG0067	glutamate synthase
FRD49_RS01695	COG0070	glutamate synthase
FRD49_RS01700	COG0493	'glutamate synthase
FRD49_RS01710	COG1704	LemA family
FRD49_RS01715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FRD49_RS01735	COG3307	-O-antigen
FRD49_RS01755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRD49_RS01770	COG0194	GDP metabolic process
FRD49_RS01805	COG4969	Belongs to the N-Me-Phe pilin family
FRD49_RS01820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRD49_RS01840	COG5380	lipid catabolic process
FRD49_RS01845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRD49_RS01860	COG5006	permease, DMT superfamily
FRD49_RS01865	COG5006	permease, DMT superfamily
FRD49_RS01870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRD49_RS01875	COG0277	FAD linked oxidase domain protein
FRD49_RS01890	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FRD49_RS01895	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_RS01910	COG1289	transmembrane transporter activity
FRD49_RS01915	COG2032	superoxide dismutase activity
FRD49_RS01920	COG0628	permease
FRD49_RS01925	COG1192	Involved in chromosome partitioning
FRD49_RS01955	COG0833	amino acid
FRD49_RS01960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRD49_RS01965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRD49_RS01975	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS02015	COG0583	DNA-binding transcription factor activity
FRD49_RS02065	COG0517	IMP dehydrogenase activity
FRD49_RS02070	COG1983	PspC domain protein
FRD49_RS02080	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS02095	COG0408	coproporphyrinogen oxidase activity
FRD49_RS02120	COG1127	ABC transporter
FRD49_RS02125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRD49_RS02135	COG2854	intermembrane phospholipid transfer
FRD49_RS02145	COG0598	Magnesium transport protein CorA
FRD49_RS02155	COG0494	nUDIX hydrolase
FRD49_RS02160	COG1040	competence protein
FRD49_RS02165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRD49_RS02185	COG1946	Acyl-CoA thioesterase
FRD49_RS02190	COG1301	dicarboxylic acid transport
FRD49_RS02205	COG1959	2 iron, 2 sulfur cluster binding
FRD49_RS02210	COG1017	nitric oxide dioxygenase activity
FRD49_RS02210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_RS02215	COG0433	COG0433 Predicted ATPase
FRD49_RS02220	COG0626	cystathionine gamma-synthase activity
FRD49_RS02235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRD49_RS02240	COG0088	Forms part of the polypeptide exit tunnel
FRD49_RS02375	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS02380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FRD49_RS02410	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FRD49_RS02415	COG0339	signal peptide processing
FRD49_RS02420	COG0557	exoribonuclease II activity
FRD49_RS02465	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRD49_RS02470	COG2207	Transcriptional regulator
FRD49_RS02480	COG1295	ribonuclease BN
FRD49_RS02515	COG1702	phosphate starvation-inducible protein PhoH
FRD49_RS02525	COG0739	heme binding
FRD49_RS02525	COG0741	lytic transglycosylase activity
FRD49_RS02525	COG1196	nuclear chromosome segregation
FRD49_RS02555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FRD49_RS02560	COG1183	phosphatidylcholine synthase activity
FRD49_RS02610	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS02615	COG1309	transcriptional regulator
FRD49_RS02630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRD49_RS02635	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS02675	COG2969	positive regulation of protein catabolic process
FRD49_RS02685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FRD49_RS02690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRD49_RS02695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FRD49_RS02700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRD49_RS02705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FRD49_RS02725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRD49_RS02735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRD49_RS02740	COG1408	metallophosphoesterase
FRD49_RS02750	COG2199	diguanylate cyclase activity
FRD49_RS02785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRD49_RS02810	COG1607	acyl-coa hydrolase
FRD49_RS02845	COG2350	Protein conserved in bacteria
FRD49_RS02855	COG0613	PHP domain protein
FRD49_RS02860	COG3781	membrane
FRD49_RS02870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FRD49_RS02875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRD49_RS02885	COG1862	Preprotein translocase
FRD49_RS02995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FRD49_RS03005	COG0732	type I restriction modification DNA specificity domain
FRD49_RS03020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRD49_RS03030	COG0784	Response regulator, receiver
FRD49_RS03030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_RS03030	COG2198	Histidine kinase
FRD49_RS03030	COG2205	protein histidine kinase activity
FRD49_RS03035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FRD49_RS03050	COG2194	sulfuric ester hydrolase activity
FRD49_RS03060	COG0726	polysaccharide deacetylase
FRD49_RS03065	COG0463	Glycosyl transferase, family 2
FRD49_RS03070	COG0438	transferase activity, transferring glycosyl groups
FRD49_RS03140	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS03145	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS03155	COG2205	protein histidine kinase activity
FRD49_RS03160	COG0745	RESPONSE REGULATOR receiver
FRD49_RS03165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FRD49_RS03185	COG2096	Adenosyltransferase
FRD49_RS03240	COG0285	dihydrofolate synthase activity
FRD49_RS03260	COG0450	alkyl hydroperoxide reductase
FRD49_RS03275	COG0477	Major facilitator Superfamily
FRD49_RS03280	COG1272	protein, Hemolysin III
FRD49_RS03290	COG2153	protein acetylation
FRD49_RS03310	COG0183	Belongs to the thiolase family
FRD49_RS03315	COG2207	Transcriptional regulator
FRD49_RS03335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_RS03355	COG0183	Belongs to the thiolase family
FRD49_RS03365	COG2885	chlorophyll binding
FRD49_RS03365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FRD49_RS03370	COG1690	Belongs to the RtcB family
FRD49_RS03375	COG0833	amino acid
FRD49_RS03385	COG2233	PERMEase
FRD49_RS03390	COG1217	gtp-binding protein TYPA
FRD49_RS03415	COG2094	Belongs to the DNA glycosylase MPG family
FRD49_RS03420	COG4772	TonB-dependent receptor
FRD49_RS03425	COG1902	pentaerythritol trinitrate reductase activity
FRD49_RS03430	COG0679	Auxin Efflux Carrier
FRD49_RS03440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRD49_RS03445	COG0354	folic acid binding
FRD49_RS03455	COG3189	MarR family transcriptional regulator
FRD49_RS03460	COG2824	Alkylphosphonate utilization operon protein PhnA
FRD49_RS03465	COG3422	double-strand break repair
FRD49_RS03505	COG0840	transmembrane signaling receptor activity
FRD49_RS03535	COG2832	Protein of unknown function (DUF454)
FRD49_RS03540	COG1376	ErfK ybiS ycfS ynhG family protein
FRD49_RS03580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FRD49_RS03590	COG1289	transmembrane transporter activity
FRD49_RS03595	COG2814	Major facilitator Superfamily
FRD49_RS03620	COG1115	amino acid carrier protein
FRD49_RS03625	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRD49_RS03630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRD49_RS03635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FRD49_RS03665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRD49_RS03675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRD49_RS03680	COG1077	Cell shape determining protein MreB Mrl
FRD49_RS03685	COG1792	Involved in formation and maintenance of cell shape
FRD49_RS03690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FRD49_RS03695	COG0424	maF-like protein
FRD49_RS03700	COG1530	ribonuclease E activity
FRD49_RS03710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRD49_RS03730	COG3293	Transposase
FRD49_RS03735	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_RS03760	COG2207	Transcriptional regulator
FRD49_RS03790	COG3046	protein related to deoxyribodipyrimidine photolyase
FRD49_RS03795	COG2816	NAD+ diphosphatase activity
FRD49_RS03800	COG1113	amino acid transport
FRD49_RS03805	COG2828	Protein conserved in bacteria
FRD49_RS03810	COG0142	geranyltranstransferase activity
FRD49_RS03815	COG2315	Protein conserved in bacteria
FRD49_RS03830	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRD49_RS03850	COG2194	sulfuric ester hydrolase activity
FRD49_RS03855	COG0745	RESPONSE REGULATOR receiver
FRD49_RS03860	COG0642	Histidine kinase
FRD49_RS03870	COG0004	ammonium transporteR
FRD49_RS03880	COG0583	DNA-binding transcription factor activity
FRD49_RS03900	COG0525	valine-tRNA ligase activity
FRD49_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS03920	COG0393	Putative heavy-metal-binding
FRD49_RS03925	COG0393	Putative heavy-metal-binding
FRD49_RS03930	COG1538	Outer membrane efflux protein
FRD49_RS03940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_RS03945	COG0671	phosphoesterase, PA-phosphatase related
FRD49_RS03975	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FRD49_RS03990	COG1648	precorrin-2 dehydrogenase activity
FRD49_RS03990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRD49_RS03995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FRD49_RS04000	COG1733	regulation of RNA biosynthetic process
FRD49_RS04010	COG0531	amino acid
FRD49_RS04025	COG0321	lipoyl(octanoyl) transferase activity
FRD49_RS04030	COG2921	Belongs to the UPF0250 family
FRD49_RS04065	COG2009	succinate dehydrogenase
FRD49_RS04070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRD49_RS04075	COG1053	succinate dehydrogenase
FRD49_RS04080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRD49_RS04105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRD49_RS04125	COG2354	Protein conserved in bacteria
FRD49_RS04130	COG2321	neutral zinc metallopeptidase
FRD49_RS04150	COG2843	Capsule synthesis protein
FRD49_RS04170	COG0589	response to stress
FRD49_RS04180	COG0251	oxidation-reduction process
FRD49_RS04185	COG1309	transcriptional regulator
FRD49_RS04200	COG0505	Belongs to the CarA family
FRD49_RS04230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRD49_RS04235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FRD49_RS04285	COG0477	Major facilitator Superfamily
FRD49_RS04290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRD49_RS04305	COG1597	lipid kinase activity
FRD49_RS04310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRD49_RS04330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_RS04335	COG0584	glycerophosphoryl diester phosphodiesterase
FRD49_RS04355	COG0741	lytic transglycosylase activity
FRD49_RS04380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRD49_RS04395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRD49_RS04405	COG3811	Belongs to the UPF0386 family
FRD49_RS04445	COG1309	transcriptional regulator
FRD49_RS04450	COG1902	pentaerythritol trinitrate reductase activity
FRD49_RS04455	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRD49_RS04455	COG0596	Alpha beta hydrolase
FRD49_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_RS04480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRD49_RS04485	COG0778	Nitroreductase
FRD49_RS04490	COG0300	oxidoreductase activity
FRD49_RS04500	COG1929	Belongs to the glycerate kinase type-1 family
FRD49_RS04505	COG0243	molybdopterin cofactor binding
FRD49_RS04515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FRD49_RS04520	COG3339	Conserved Protein
FRD49_RS04530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FRD49_RS04545	COG1113	amino acid transport
FRD49_RS04550	COG1113	amino acid transport
FRD49_RS04560	COG0019	diaminopimelate decarboxylase activity
FRD49_RS04570	COG1280	lysine exporter protein (LysE YggA)
FRD49_RS04575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FRD49_RS04595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_RS04605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FRD49_RS04615	COG0463	Glycosyl transferase, family 2
FRD49_RS04635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_RS04665	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRD49_RS04670	COG1136	(ABC) transporter
FRD49_RS04685	COG0616	signal peptide processing
FRD49_RS04685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRD49_RS04690	COG0596	Alpha beta hydrolase
FRD49_RS04695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRD49_RS04705	COG0628	permease
FRD49_RS04740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRD49_RS04760	COG0823	Involved in the tonB-independent uptake of proteins
FRD49_RS04780	COG0824	Thioesterase
FRD49_RS04785	COG1473	amidohydrolase
FRD49_RS04805	COG0047	phosphoribosylformylglycinamidine synthase activity
FRD49_RS04805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRD49_RS04810	COG2814	Major facilitator Superfamily
FRD49_RS04825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRD49_RS04830	COG1024	Enoyl-CoA hydratase
FRD49_RS04835	COG1051	belongs to the nudix hydrolase family
FRD49_RS04835	COG1056	cytidyltransferase-related domain
FRD49_RS04850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRD49_RS04865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRD49_RS04870	COG0602	queuosine metabolic process
FRD49_RS04880	COG4625	pathogenesis
FRD49_RS04885	COG0583	DNA-binding transcription factor activity
FRD49_RS04890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRD49_RS04895	COG4208	sulfate ABC transporter
FRD49_RS04900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FRD49_RS04910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FRD49_RS04915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRD49_RS04920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FRD49_RS04940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRD49_RS04955	COG0481	GTPase activity
FRD49_RS04960	COG0681	Belongs to the peptidase S26 family
FRD49_RS04975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRD49_RS04985	COG1381	Involved in DNA repair and RecF pathway recombination
FRD49_RS04990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRD49_RS05000	COG4221	oxidoreductase activity
FRD49_RS05030	COG0436	Aminotransferase
FRD49_RS05050	COG0556	nucleotide-excision repair
FRD49_RS05105	COG2070	2-Nitropropane dioxygenase
FRD49_RS05145	COG1215	transferase activity, transferring glycosyl groups
FRD49_RS05160	COG0415	Belongs to the DNA photolyase family
FRD49_RS05170	COG1252	NADH dehydrogenase
FRD49_RS05175	COG1686	Belongs to the peptidase S11 family
FRD49_RS05190	COG1187	pseudouridine synthase activity
FRD49_RS05215	COG0477	Major facilitator Superfamily
FRD49_RS05220	COG0583	DNA-binding transcription factor activity
FRD49_RS05225	COG1823	symporter activity
FRD49_RS05235	COG0612	Peptidase, M16
FRD49_RS05260	COG0352	thiamine-phosphate diphosphorylase activity
FRD49_RS05295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_RS05320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FRD49_RS05325	COG0076	glutamate decarboxylase activity
FRD49_RS05335	COG1522	sequence-specific DNA binding
FRD49_RS05340	COG3961	Belongs to the TPP enzyme family
FRD49_RS05345	COG1113	amino acid transport
FRD49_RS05350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRD49_RS05355	COG0573	inorganic phosphate transmembrane transporter activity
FRD49_RS05365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRD49_RS05370	COG0616	signal peptide processing
FRD49_RS05385	COG3647	Membrane
FRD49_RS05410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FRD49_RS05415	COG1686	Belongs to the peptidase S11 family
FRD49_RS05440	COG0583	DNA-binding transcription factor activity
FRD49_RS05445	COG1067	ATP-dependent peptidase activity
FRD49_RS05470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FRD49_RS05485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRD49_RS05490	COG1966	Carbon starvation protein
FRD49_RS05495	COG2879	small protein
FRD49_RS05535	COG0653	protein targeting
FRD49_RS05560	COG2964	Protein conserved in bacteria
FRD49_RS05565	COG1741	Belongs to the pirin family
FRD49_RS05585	COG3739	integral membrane protein
FRD49_RS05615	COG0302	gtp cyclohydrolase
FRD49_RS05625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRD49_RS05635	COG2840	Smr protein MutS2
FRD49_RS05655	COG2801	Transposase and inactivated derivatives
FRD49_RS05670	COG0308	aminopeptidase N
FRD49_RS05675	COG0512	Glutamine amidotransferase of anthranilate synthase
FRD49_RS05700	COG0174	glutamine synthetase
FRD49_RS05710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRD49_RS05745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRD49_RS05750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRD49_RS05755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRD49_RS05775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRD49_RS05780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FRD49_RS05785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRD49_RS05800	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS05805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRD49_RS05810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRD49_RS05820	COG2223	nitrite transmembrane transporter activity
FRD49_RS05830	COG0024	Methionine aminopeptidase
FRD49_RS05835	COG0052	Belongs to the universal ribosomal protein uS2 family
FRD49_RS05850	COG2207	Transcriptional regulator
FRD49_RS05875	COG2951	lytic endotransglycosylase activity
FRD49_RS05880	COG0772	Belongs to the SEDS family
FRD49_RS05895	COG0842	Transport permease protein
FRD49_RS05900	COG1131	(ABC) transporter
FRD49_RS05940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_RS05955	COG4215	(ABC) transporter
FRD49_RS05960	COG4160	amino acid transport
FRD49_RS05965	COG4598	ABC transporter
FRD49_RS05975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRD49_RS05980	COG0826	peptidase U32
FRD49_RS05985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_RS05990	COG0384	phenazine biosynthesis protein PhzF
FRD49_RS06000	COG1720	tRNA m6t6A37 methyltransferase activity
FRD49_RS06010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRD49_RS06015	COG3111	PFAM Bacterial OB fold (BOF) protein
FRD49_RS06025	COG0642	Histidine kinase
FRD49_RS06035	COG0494	nUDIX hydrolase
FRD49_RS06045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRD49_RS06050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRD49_RS06055	COG3139	Protein of unknown function (DUF1315)
FRD49_RS06060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRD49_RS06070	COG1301	dicarboxylic acid transport
FRD49_RS06075	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS06085	COG2819	hydrolase of the alpha beta superfamily
FRD49_RS06095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRD49_RS06105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRD49_RS06110	COG2195	Cleaves the N-terminal amino acid of tripeptides
FRD49_RS06115	COG1234	tRNA 3'-trailer cleavage
FRD49_RS06140	COG2363	Small membrane protein
FRD49_RS06160	COG0513	Belongs to the DEAD box helicase family
FRD49_RS06170	COG0778	Nitroreductase
FRD49_RS06200	COG1286	toxin biosynthetic process
FRD49_RS06230	COG1610	YqeY-like protein
FRD49_RS06260	COG0515	serine threonine protein kinase
FRD49_RS06260	COG2815	serine threonine protein kinase
FRD49_RS06285	COG2831	hemolysin activation secretion protein
FRD49_RS06410	COG2226	methyltransferase
FRD49_RS06420	COG3111	PFAM Bacterial OB fold (BOF) protein
FRD49_RS06435	COG3243	poly(R)-hydroxyalkanoic acid synthase
FRD49_RS06440	COG0786	glutamate:sodium symporter activity
FRD49_RS06445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRD49_RS06445	COG0475	glutathione-regulated potassium exporter activity
FRD49_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS06520	COG1073	alpha beta
FRD49_RS06530	COG0583	DNA-binding transcription factor activity
FRD49_RS06565	COG1051	belongs to the nudix hydrolase family
FRD49_RS06590	COG3293	Transposase
FRD49_RS06605	COG2995	paraquat-inducible protein a
FRD49_RS06610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FRD49_RS06610	COG3008	intermembrane lipid transfer
FRD49_RS06620	COG2351	hydroxyisourate hydrolase activity
FRD49_RS06635	COG5002	protein histidine kinase activity
FRD49_RS06660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRD49_RS06670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRD49_RS06675	COG0642	Histidine kinase
FRD49_RS06680	COG0745	RESPONSE REGULATOR receiver
FRD49_RS06720	COG1301	dicarboxylic acid transport
FRD49_RS06730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_RS06735	COG2011	ABC-type metal ion transport system permease component
FRD49_RS06740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRD49_RS06745	COG1464	Belongs to the NlpA lipoprotein family
FRD49_RS06750	COG0151	Belongs to the GarS family
FRD49_RS06755	COG0138	bifunctional purine biosynthesis protein purh
FRD49_RS06760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FRD49_RS06790	COG2308	Evidence 4 Homologs of previously reported genes of
FRD49_RS06800	COG1305	Transglutaminase-like
FRD49_RS06810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRD49_RS06815	COG0305	Participates in initiation and elongation during chromosome replication
FRD49_RS06840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FRD49_RS06850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRD49_RS06885	COG1215	transferase activity, transferring glycosyl groups
FRD49_RS06890	COG3658	cytochrome
FRD49_RS06900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRD49_RS06925	COG0583	DNA-binding transcription factor activity
FRD49_RS06945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_RS06950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_RS06965	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS06970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRD49_RS06975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_RS07000	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FRD49_RS07005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FRD49_RS07010	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FRD49_RS07015	COG2205	protein histidine kinase activity
FRD49_RS07020	COG0745	RESPONSE REGULATOR receiver
FRD49_RS07025	COG0174	glutamine synthetase
FRD49_RS07045	COG0729	surface antigen
FRD49_RS07075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRD49_RS07080	COG2814	Major facilitator Superfamily
FRD49_RS07090	COG0583	DNA-binding transcription factor activity
FRD49_RS07105	COG1187	pseudouridine synthase activity
FRD49_RS07125	COG0802	atpase or kinase
FRD49_RS07130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRD49_RS07140	COG1923	regulation of RNA biosynthetic process
FRD49_RS07145	COG0697	spore germination
FRD49_RS07175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRD49_RS07175	COG0519	Catalyzes the synthesis of GMP from XMP
FRD49_RS07180	COG4302	ethanolamine ammonia-lyase activity
FRD49_RS07185	COG4303	Ethanolamine ammonia lyase large subunit
FRD49_RS07190	COG0531	amino acid
FRD49_RS07210	COG1454	alcohol dehydrogenase
FRD49_RS07215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRD49_RS07225	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FRD49_RS07245	COG0308	aminopeptidase N
FRD49_RS07285	COG0625	glutathione transferase activity
FRD49_RS07310	COG1605	Chorismate mutase
FRD49_RS07350	COG4264	IucA IucC family
FRD49_RS07360	COG4264	IucA IucC family
FRD49_RS07365	COG2423	ornithine cyclodeaminase activity
FRD49_RS07370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRD49_RS07375	COG0668	transmembrane transport
FRD49_RS07445	COG0488	(ABC) transporter
FRD49_RS07450	COG0589	response to stress
FRD49_RS07465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FRD49_RS07475	COG3135	benzoate transporter
FRD49_RS07480	COG1522	sequence-specific DNA binding
FRD49_RS07490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRD49_RS07495	COG0583	DNA-binding transcription factor activity
FRD49_RS07505	COG0183	Belongs to the thiolase family
FRD49_RS07515	COG2030	dehydratase
FRD49_RS07520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRD49_RS07545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRD49_RS07555	COG0824	Thioesterase
FRD49_RS07560	COG1454	alcohol dehydrogenase
FRD49_RS07570	COG1335	isochorismatase
FRD49_RS07590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRD49_RS07615	COG3293	Transposase
FRD49_RS07625	COG0069	glutamate synthase activity
FRD49_RS07665	COG2814	Major facilitator Superfamily
FRD49_RS07675	COG0439	Biotin carboxylase
FRD49_RS07680	COG0511	ligase activity, forming carbon-carbon bonds
FRD49_RS07695	COG1116	anion transmembrane transporter activity
FRD49_RS07695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_RS07700	COG0745	RESPONSE REGULATOR receiver
FRD49_RS07710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_RS07710	COG2146	nitrite reductase [NAD(P)H] activity
FRD49_RS07715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_RS07720	COG0243	molybdopterin cofactor binding
FRD49_RS07730	COG0243	molybdopterin cofactor binding
FRD49_RS07735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRD49_RS07750	COG0315	cyclic pyranopterin monophosphate synthase activity
FRD49_RS07750	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRD49_RS07755	COG0303	'Molybdopterin
FRD49_RS07765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_RS07770	COG0697	spore germination
FRD49_RS07790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FRD49_RS07795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRD49_RS07855	COG2204	response regulator
FRD49_RS07860	COG3852	Histidine kinase
FRD49_RS07885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRD49_RS07890	COG0575	Belongs to the CDS family
FRD49_RS07925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRD49_RS07940	COG2137	regulation of response to DNA damage stimulus
FRD49_RS07950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FRD49_RS07955	COG1011	Hydrolase
FRD49_RS07975	COG1522	sequence-specific DNA binding
FRD49_RS07985	COG1113	amino acid transport
FRD49_RS08010	COG0659	secondary active sulfate transmembrane transporter activity
FRD49_RS08015	COG2135	peptidase activity
FRD49_RS08030	COG3300	MHYT domain
FRD49_RS08030	COG5001	Diguanylate cyclase
FRD49_RS08045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRD49_RS08045	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FRD49_RS08045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRD49_RS08050	COG1105	Belongs to the carbohydrate kinase PfkB family
FRD49_RS08055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRD49_RS08055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRD49_RS08085	COG0024	Methionine aminopeptidase
FRD49_RS08090	COG0583	DNA-binding transcription factor activity
FRD49_RS08100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FRD49_RS08105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRD49_RS08110	COG0517	IMP dehydrogenase activity
FRD49_RS08110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FRD49_RS08140	COG0552	protein localization to endoplasmic reticulum
FRD49_RS08150	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FRD49_RS08165	COG4890	Cyd operon protein YbgT
FRD49_RS08170	COG1294	oxidase, subunit
FRD49_RS08185	COG1585	Membrane protein implicated in regulation of membrane protease activity
FRD49_RS08195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRD49_RS08200	COG4774	siderophore transport
FRD49_RS08215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FRD49_RS08220	COG0569	domain protein
FRD49_RS08225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRD49_RS08255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRD49_RS08260	COG0542	response to heat
FRD49_RS08270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRD49_RS08285	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRD49_RS08285	COG1902	pentaerythritol trinitrate reductase activity
FRD49_RS08330	COG2323	membrane
FRD49_RS08340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FRD49_RS08350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRD49_RS08355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRD49_RS08360	COG0183	Belongs to the thiolase family
FRD49_RS08365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRD49_RS08370	COG0596	Alpha beta hydrolase
FRD49_RS08375	COG2271	Major facilitator Superfamily
FRD49_RS08380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRD49_RS08385	COG3485	protocatechuate 3,4-dioxygenase
FRD49_RS08390	COG3485	protocatechuate 3,4-dioxygenase
FRD49_RS08395	COG0710	3-dehydroquinate dehydratase activity
FRD49_RS08400	COG3420	alginic acid biosynthetic process
FRD49_RS08405	COG3659	wide pore channel activity
FRD49_RS08410	COG4993	Dehydrogenase
FRD49_RS08420	COG2391	methyltransferase activity
FRD49_RS08435	COG1414	Transcriptional regulator
FRD49_RS08440	COG0583	DNA-binding transcription factor activity
FRD49_RS08445	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS08470	COG2814	Major facilitator Superfamily
FRD49_RS08480	COG0154	amidase activity
FRD49_RS08500	COG4638	Rieske (2fe-2S)
FRD49_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS08520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_RS08530	COG3733	amine oxidase
FRD49_RS08540	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS08550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRD49_RS08555	COG0183	Belongs to the thiolase family
FRD49_RS08560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRD49_RS08565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRD49_RS08575	COG4829	muconolactone delta-isomerase
FRD49_RS08580	COG4948	Mandelate Racemase Muconate Lactonizing
FRD49_RS08585	COG0583	DNA-binding transcription factor activity
FRD49_RS08595	COG2186	Transcriptional regulator
FRD49_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS08640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRD49_RS08650	COG0789	Transcriptional regulator
FRD49_RS08665	COG1309	transcriptional regulator
FRD49_RS08680	COG1309	transcriptional regulator
FRD49_RS08715	COG2188	Transcriptional regulator
FRD49_RS08720	COG0583	DNA-binding transcription factor activity
FRD49_RS08735	COG1566	PFAM secretion protein HlyD family protein
FRD49_RS08750	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS08755	COG0129	dihydroxy-acid dehydratase activity
FRD49_RS08765	COG0583	DNA-binding transcription factor activity
FRD49_RS08770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRD49_RS08780	COG2084	Dehydrogenase
FRD49_RS08790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRD49_RS08795	COG1120	ATPase activity
FRD49_RS08815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRD49_RS08910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRD49_RS08950	COG1064	alcohol dehydrogenase
FRD49_RS08955	COG4221	oxidoreductase activity
FRD49_RS08960	COG1073	alpha beta
FRD49_RS08965	COG0583	DNA-binding transcription factor activity
FRD49_RS08980	COG1309	transcriptional regulator
FRD49_RS08990	COG2205	protein histidine kinase activity
FRD49_RS08995	COG0745	RESPONSE REGULATOR receiver
FRD49_RS09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_RS09020	COG1538	Outer membrane efflux protein
FRD49_RS09095	COG3539	Fimbrial protein
FRD49_RS09120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FRD49_RS09130	COG0753	catalase activity
FRD49_RS09145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRD49_RS09210	COG4771	TonB-dependent receptor
FRD49_RS09215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRD49_RS09220	COG3433	isochorismatase activity
FRD49_RS09220	COG1535	isochorismatase
FRD49_RS09225	COG1021	2,3-dihydroxybenzoate-AMP ligase
FRD49_RS09230	COG1169	isochorismate synthase
FRD49_RS09235	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS09245	COG3251	PFAM MbtH domain protein
FRD49_RS09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRD49_RS09280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FRD49_RS09285	COG4149	molybdate abc transporter
FRD49_RS09290	COG0725	ABC transporter, periplasmic molybdate-binding protein
FRD49_RS09300	COG4638	Rieske (2fe-2S)
FRD49_RS09305	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FRD49_RS09310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_RS09310	COG0543	2 iron, 2 sulfur cluster binding
FRD49_RS09325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS09345	COG2271	Major facilitator Superfamily
FRD49_RS09350	COG2207	Transcriptional regulator
FRD49_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS09360	COG2610	gluconate transmembrane transporter activity
FRD49_RS09365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_RS09415	COG0583	DNA-binding transcription factor activity
FRD49_RS09430	COG2031	fatty acid transporter
FRD49_RS09435	COG0183	Belongs to the thiolase family
FRD49_RS09440	COG0583	DNA-binding transcription factor activity
FRD49_RS09445	COG0583	DNA-binding transcription factor activity
FRD49_RS09460	COG1027	Aspartate ammonia-lyase
FRD49_RS09470	COG0477	Major facilitator Superfamily
FRD49_RS09490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_RS09495	COG4521	taurine ABC transporter
FRD49_RS09510	COG2188	Transcriptional regulator
FRD49_RS09520	COG3708	Transcriptional regulator
FRD49_RS09520	COG2207	Transcriptional regulator
FRD49_RS09535	COG0730	response to heat
FRD49_RS09545	COG3453	Protein conserved in bacteria
FRD49_RS09545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_RS09555	COG3781	membrane
FRD49_RS09560	COG1063	alcohol dehydrogenase
FRD49_RS09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRD49_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRD49_RS09580	COG0022	dehydrogenase e1 component
FRD49_RS09585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRD49_RS09590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRD49_RS09620	COG0133	tryptophan synthase activity
FRD49_RS09630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRD49_RS09665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRD49_RS09690	COG2226	methyltransferase
FRD49_RS09740	COG0842	Transport permease protein
FRD49_RS09745	COG0842	Transport permease protein
FRD49_RS09750	COG1131	(ABC) transporter
FRD49_RS09770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRD49_RS09775	COG4773	Receptor
FRD49_RS09795	COG0730	response to heat
FRD49_RS09800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRD49_RS09810	COG4772	TonB-dependent receptor
FRD49_RS09825	COG0406	alpha-ribazole phosphatase activity
FRD49_RS09830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FRD49_RS09855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FRD49_RS09870	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS09875	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS09880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRD49_RS09885	COG2207	Transcriptional regulator
FRD49_RS09890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRD49_RS09895	COG0776	regulation of translation
FRD49_RS09920	COG0822	iron-sulfur transferase activity
FRD49_RS09925	COG0316	Belongs to the HesB IscA family
FRD49_RS09955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRD49_RS09975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FRD49_RS09980	COG0702	epimerase
FRD49_RS10010	COG4172	Belongs to the ABC transporter superfamily
FRD49_RS10015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRD49_RS10020	COG0601	transmembrane transport
FRD49_RS10025	COG0339	signal peptide processing
FRD49_RS10050	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FRD49_RS10075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FRD49_RS10080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FRD49_RS10095	COG2431	L-lysine efflux transmembrane transporter activity
FRD49_RS10110	COG0776	regulation of translation
FRD49_RS10175	COG0084	hydrolase, TatD family'
FRD49_RS10195	COG1663	tetraacyldisaccharide 4'-kinase activity
FRD49_RS10200	COG1132	(ABC) transporter
FRD49_RS10210	COG0811	peptide transport
FRD49_RS10215	COG1475	DNA binding
FRD49_RS10220	COG1192	Involved in chromosome partitioning
FRD49_RS10230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRD49_RS10245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRD49_RS10250	COG0191	fructose-bisphosphate aldolase activity
FRD49_RS10270	COG0424	maF-like protein
FRD49_RS10275	COG2850	peptidyl-arginine hydroxylation
FRD49_RS10285	COG0640	Transcriptional regulator
FRD49_RS10295	COG3619	membrane
FRD49_RS10300	COG3122	Protein conserved in bacteria
FRD49_RS10305	COG1132	(ABC) transporter
FRD49_RS10325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FRD49_RS10330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRD49_RS10345	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRD49_RS10345	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRD49_RS10345	COG0506	proline dehydrogenase activity
FRD49_RS10350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FRD49_RS10365	COG3698	Phosphodiester glycosidase
FRD49_RS10375	COG2353	YceI-like domain
FRD49_RS10395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRD49_RS10435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FRD49_RS10435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRD49_RS10460	COG3539	Fimbrial protein
FRD49_RS10465	COG3121	Chaperone
FRD49_RS10505	COG0697	spore germination
FRD49_RS10515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FRD49_RS10525	COG0583	DNA-binding transcription factor activity
FRD49_RS10545	COG1309	transcriptional regulator
FRD49_RS10560	COG1522	sequence-specific DNA binding
FRD49_RS10570	COG1126	abc transporter atp-binding protein
FRD49_RS10575	COG0765	amino acid transport
FRD49_RS10580	COG0765	amino acid transport
FRD49_RS10610	COG1464	Belongs to the NlpA lipoprotein family
FRD49_RS10615	COG1464	Belongs to the NlpA lipoprotein family
FRD49_RS10620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRD49_RS10625	COG2011	ABC-type metal ion transport system permease component
FRD49_RS10630	COG0012	GTP binding
FRD49_RS10655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FRD49_RS10685	COG1280	lysine exporter protein (LysE YggA)
FRD49_RS10695	COG0386	Belongs to the glutathione peroxidase family
FRD49_RS10705	COG0436	Aminotransferase
FRD49_RS10710	COG1301	dicarboxylic acid transport
FRD49_RS10745	COG3634	alkyl hydroperoxide reductase activity
FRD49_RS10760	COG0583	DNA-binding transcription factor activity
FRD49_RS10765	COG0798	PFAM Bile acid sodium symporter
FRD49_RS10770	COG0640	Transcriptional regulator
FRD49_RS10795	COG0583	DNA-binding transcription factor activity
FRD49_RS10805	COG1953	Uracil, thiamine, allantoin
FRD49_RS10815	COG2175	clavaminate synthase activity
FRD49_RS10820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_RS10825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FRD49_RS10830	COG4521	taurine ABC transporter
FRD49_RS10840	COG0477	Major facilitator Superfamily
FRD49_RS10865	COG1271	oxidase subunit
FRD49_RS10870	COG1294	oxidase, subunit
FRD49_RS10880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_RS10900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRD49_RS10920	COG3052	prosthetic group binding
FRD49_RS10925	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FRD49_RS10945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_RS10950	COG1346	cytolysis
FRD49_RS10960	COG0583	DNA-binding transcription factor activity
FRD49_RS10965	COG0625	glutathione transferase activity
FRD49_RS10970	COG0625	glutathione transferase activity
FRD49_RS10975	COG0583	DNA-binding transcription factor activity
FRD49_RS10990	COG1045	serine acetyltransferase
FRD49_RS10995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRD49_RS11000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRD49_RS11005	COG1280	lysine exporter protein (LysE YggA)
FRD49_RS11020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_RS11025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_RS11030	COG1126	abc transporter atp-binding protein
FRD49_RS11035	COG0765	amino acid transport
FRD49_RS11040	COG0765	amino acid transport
FRD49_RS11060	COG0784	Response regulator, receiver
FRD49_RS11060	COG2205	protein histidine kinase activity
FRD49_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS11155	COG0583	DNA-binding transcription factor activity
FRD49_RS11175	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_RS11180	COG1309	transcriptional regulator
FRD49_RS11185	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS11190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRD49_RS11195	COG1024	Enoyl-CoA hydratase
FRD49_RS11200	COG4770	biotin carboxylase activity
FRD49_RS11210	COG0583	DNA-binding transcription factor activity
FRD49_RS11225	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS11235	COG2814	Major facilitator Superfamily
FRD49_RS11245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRD49_RS11250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRD49_RS11255	COG2814	Major facilitator Superfamily
FRD49_RS11260	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS11265	COG1024	Enoyl-CoA hydratase
FRD49_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS11275	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRD49_RS11280	COG0183	Belongs to the thiolase family
FRD49_RS11290	COG2814	Major facilitator Superfamily
FRD49_RS11300	COG1024	Enoyl-CoA hydratase
FRD49_RS11315	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS11320	COG2814	Major facilitator Superfamily
FRD49_RS11325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRD49_RS11330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FRD49_RS11330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRD49_RS11345	COG3842	ATPase activity
FRD49_RS11350	COG1840	ABC-type Fe3 transport system, periplasmic component
FRD49_RS11360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_RS11365	COG1414	Transcriptional regulator
FRD49_RS11375	COG0583	DNA-binding transcription factor activity
FRD49_RS11410	COG0477	Major facilitator Superfamily
FRD49_RS11425	COG1116	anion transmembrane transporter activity
FRD49_RS11430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRD49_RS11440	COG0864	Transcriptional regulator
FRD49_RS11450	COG1733	regulation of RNA biosynthetic process
FRD49_RS11455	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRD49_RS11460	COG0439	Biotin carboxylase
FRD49_RS11475	COG1063	alcohol dehydrogenase
FRD49_RS11515	COG3293	Transposase
FRD49_RS11555	COG0038	chloride channel
FRD49_RS11560	COG4770	biotin carboxylase activity
FRD49_RS11580	COG1914	H( )-stimulated, divalent metal cation uptake system
FRD49_RS11585	COG0583	DNA-binding transcription factor activity
FRD49_RS11595	COG1595	DNA-templated transcription, initiation
FRD49_RS11605	COG3220	belongs to the UPF0276 family
FRD49_RS11620	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS11635	COG2076	Multidrug Resistance protein
FRD49_RS11650	COG3713	MltA-interacting MipA family protein
FRD49_RS11655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRD49_RS11730	COG1011	Hydrolase
FRD49_RS11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRD49_RS11765	COG0789	Transcriptional regulator
FRD49_RS11770	COG1278	Cold shock
FRD49_RS11780	COG0626	cystathionine gamma-synthase activity
FRD49_RS11790	COG1522	sequence-specific DNA binding
FRD49_RS11805	COG4774	siderophore transport
FRD49_RS11825	COG2814	Major facilitator Superfamily
FRD49_RS11875	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS11910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRD49_RS11920	COG4122	O-methyltransferase activity
FRD49_RS11950	COG1538	Outer membrane efflux protein
FRD49_RS11955	COG1137	ATPase activity
FRD49_RS11960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FRD49_RS11970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FRD49_RS11975	COG0517	IMP dehydrogenase activity
FRD49_RS11975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FRD49_RS12055	COG1280	lysine exporter protein (LysE YggA)
FRD49_RS12085	COG1570	exodeoxyribonuclease VII activity
FRD49_RS12170	COG2871	sodium ion transport
FRD49_RS12180	COG0583	DNA-binding transcription factor activity
FRD49_RS12185	COG4638	Rieske (2fe-2S)
FRD49_RS12190	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FRD49_RS12195	COG0633	Ferredoxin
FRD49_RS12195	COG0543	2 iron, 2 sulfur cluster binding
FRD49_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS12205	COG3135	benzoate transporter
FRD49_RS12210	COG2814	Major facilitator Superfamily
FRD49_RS12225	COG1643	Atp-dependent helicase
FRD49_RS12230	COG0450	alkyl hydroperoxide reductase
FRD49_RS12250	COG3634	alkyl hydroperoxide reductase activity
FRD49_RS12270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRD49_RS12290	COG0625	glutathione transferase activity
FRD49_RS12300	COG2885	chlorophyll binding
FRD49_RS12335	COG0542	response to heat
FRD49_RS12350	COG1765	OsmC-like protein
FRD49_RS12360	COG0667	Aldo Keto reductase
FRD49_RS12375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRD49_RS12395	COG0582	viral genome integration into host DNA
FRD49_RS12455	COG3293	Transposase
FRD49_RS12555	COG3567	Phage-associated protein, HI1409 family
FRD49_RS12560	COG5410	chromosome segregation
FRD49_RS12700	COG0527	aspartate kinase activity
FRD49_RS12710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRD49_RS12720	COG3038	cytochrome b561
FRD49_RS12725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRD49_RS12730	COG2252	PERMEase
FRD49_RS12740	COG2072	flavoprotein involved in K transport
FRD49_RS12755	COG1741	Belongs to the pirin family
FRD49_RS12760	COG1309	transcriptional regulator
FRD49_RS12775	COG2072	flavoprotein involved in K transport
FRD49_RS12780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FRD49_RS12810	COG1944	ATP diphosphatase activity
FRD49_RS12830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRD49_RS12845	COG2814	Major facilitator Superfamily
FRD49_RS12850	COG1024	Enoyl-CoA hydratase
FRD49_RS12855	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS12865	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS12905	COG1113	amino acid transport
FRD49_RS12925	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS12945	COG0531	amino acid
FRD49_RS12955	COG1113	amino acid transport
FRD49_RS13040	COG3209	COG3209 Rhs family protein
FRD49_RS13090	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FRD49_RS13100	COG1230	cation diffusion facilitator family transporter
FRD49_RS13115	COG2814	Major facilitator Superfamily
FRD49_RS13220	COG0582	viral genome integration into host DNA
FRD49_RS13230	COG1902	pentaerythritol trinitrate reductase activity
FRD49_RS13230	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRD49_RS13245	COG4251	negative regulation of phosphorylation
FRD49_RS13245	COG2203	Gaf domain
FRD49_RS13245	COG3706	GGDEF domain
FRD49_RS13245	COG5001	Diguanylate cyclase
FRD49_RS13255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRD49_RS13280	COG4172	Belongs to the ABC transporter superfamily
FRD49_RS13285	COG4239	(ABC) transporter, permease
FRD49_RS13290	COG4174	ABC transporter (Permease)
FRD49_RS13300	COG0741	lytic transglycosylase activity
FRD49_RS13300	COG0741	lytic transglycosylase activity
FRD49_RS13300	COG1388	LysM domain
FRD49_RS13300	COG1388	LysM domain
FRD49_RS13340	COG0583	DNA-binding transcription factor activity
FRD49_RS13345	COG1279	arginine transmembrane transporter activity
FRD49_RS13365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_RS13370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRD49_RS13375	COG0006	proline dipeptidase activity
FRD49_RS13410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRD49_RS13440	COG3384	dioxygenase
FRD49_RS13450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRD49_RS13455	COG2878	Part of a membrane complex involved in electron transport
FRD49_RS13460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRD49_RS13485	COG0768	penicillin binding
FRD49_RS13490	COG0742	ribosomal rna small subunit methyltransferase
FRD49_RS13510	COG0830	nickel cation binding
FRD49_RS13520	COG0804	urea catabolic process
FRD49_RS13565	COG1253	flavin adenine dinucleotide binding
FRD49_RS13570	COG2851	Citrate transporter
FRD49_RS13625	COG1773	rubredoxin
FRD49_RS13630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRD49_RS13640	COG0583	DNA-binding transcription factor activity
FRD49_RS13665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FRD49_RS13670	COG4181	ATPase activity
FRD49_RS13745	COG0306	phosphate transporter
FRD49_RS13770	COG2223	nitrite transmembrane transporter activity
FRD49_RS13775	COG0662	Cupin 2, conserved barrel domain protein
FRD49_RS13775	COG2207	Transcriptional regulator
FRD49_RS13780	COG2066	Belongs to the glutaminase family
FRD49_RS13785	COG0242	peptide deformylase activity
FRD49_RS13790	COG0477	Major facilitator Superfamily
FRD49_RS13800	COG0028	Belongs to the TPP enzyme family
FRD49_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS13820	COG2267	carboxylic ester hydrolase activity
FRD49_RS13830	COG2271	Major facilitator Superfamily
FRD49_RS13835	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRD49_RS13845	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS13865	COG1414	Transcriptional regulator
FRD49_RS13880	COG1024	Enoyl-CoA hydratase
FRD49_RS13890	COG1215	transferase activity, transferring glycosyl groups
FRD49_RS13895	COG0726	polysaccharide deacetylase
FRD49_RS13895	COG1649	PFAM Uncharacterised BCR, COG1649
FRD49_RS13905	COG4681	YaeQ
FRD49_RS13915	COG0523	cobalamin synthesis protein
FRD49_RS13925	COG1607	acyl-coa hydrolase
FRD49_RS13935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRD49_RS13940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRD49_RS13945	COG1309	transcriptional regulator
FRD49_RS13970	COG2040	homocysteine
FRD49_RS13975	COG0531	amino acid
FRD49_RS13995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRD49_RS14000	COG0477	Major facilitator Superfamily
FRD49_RS14030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRD49_RS14035	COG3586	endonuclease activity
FRD49_RS14080	COG0405	Gamma-glutamyltransferase
FRD49_RS14085	COG2814	Major facilitator Superfamily
FRD49_RS14095	COG2050	protein possibly involved in aromatic compounds catabolism
FRD49_RS14110	COG1090	epimerase
FRD49_RS14130	COG0420	3'-5' exonuclease activity
FRD49_RS14140	COG1968	undecaprenyl-diphosphatase activity
FRD49_RS14160	COG0735	belongs to the Fur family
FRD49_RS14165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRD49_RS14190	COG0121	glutamine amidotransferase
FRD49_RS14205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRD49_RS14215	COG0210	DNA helicase
FRD49_RS14220	COG2885	chlorophyll binding
FRD49_RS14225	COG0204	Acyl-transferase
FRD49_RS14240	COG2894	cell division
FRD49_RS14255	COG1280	lysine exporter protein (LysE YggA)
FRD49_RS14260	COG1674	ftsk spoiiie
FRD49_RS14265	COG0492	ferredoxin-NADP+ reductase activity
FRD49_RS14270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FRD49_RS14280	COG0456	acetyltransferase
FRD49_RS14310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRD49_RS14325	COG1981	membrane
FRD49_RS14340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRD49_RS14340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRD49_RS14360	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS14365	COG4638	Rieske (2fe-2S)
FRD49_RS14370	COG0657	acetylesterase activity
FRD49_RS14380	COG0473	3-isopropylmalate dehydrogenase activity
FRD49_RS14385	COG0583	DNA-binding transcription factor activity
FRD49_RS14405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRD49_RS14440	COG0358	DNA primase activity
FRD49_RS14455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FRD49_RS14485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRD49_RS14525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRD49_RS14535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRD49_RS14535	COG0352	thiamine-phosphate diphosphorylase activity
FRD49_RS14535	COG0351	phosphomethylpyrimidine kinase
FRD49_RS14540	COG1652	LysM domain
FRD49_RS14565	COG1399	metal-binding, possibly nucleic acid-binding protein
FRD49_RS14570	COG3101	peptidyl-lysine hydroxylation
FRD49_RS14575	COG0009	L-threonylcarbamoyladenylate synthase
FRD49_RS14580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FRD49_RS14585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRD49_RS14600	COG4106	trans-aconitate 2-methyltransferase activity
FRD49_RS14615	COG0596	Alpha beta hydrolase
FRD49_RS14615	COG2226	methyltransferase
FRD49_RS14615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRD49_RS14620	COG1877	trehalose-phosphatase activity
FRD49_RS14625	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FRD49_RS14630	COG2223	nitrite transmembrane transporter activity
FRD49_RS14650	COG1196	nuclear chromosome segregation
FRD49_RS14660	COG0730	response to heat
FRD49_RS14675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRD49_RS14740	COG0489	protein tyrosine kinase activity
FRD49_RS14755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRD49_RS14755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRD49_RS14790	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FRD49_RS14795	COG2081	HI0933 family
FRD49_RS14805	COG0668	transmembrane transport
FRD49_RS14825	COG0583	DNA-binding transcription factor activity
FRD49_RS14850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRD49_RS14855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRD49_RS14885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRD49_RS14910	COG3706	GGDEF domain
FRD49_RS14925	COG0745	RESPONSE REGULATOR receiver
FRD49_RS14945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRD49_RS14955	COG0384	phenazine biosynthesis protein PhzF
FRD49_RS14980	COG2801	Transposase and inactivated derivatives
FRD49_RS15005	COG1309	transcriptional regulator
FRD49_RS15015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRD49_RS15030	COG0583	DNA-binding transcription factor activity
FRD49_RS15040	COG0583	DNA-binding transcription factor activity
FRD49_RS15060	COG0583	DNA-binding transcription factor activity
FRD49_RS15065	COG1053	succinate dehydrogenase
FRD49_RS15090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRD49_RS15095	COG2814	Major facilitator Superfamily
FRD49_RS15100	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS15105	COG0583	DNA-binding transcription factor activity
FRD49_RS15110	COG1063	alcohol dehydrogenase
FRD49_RS15140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FRD49_RS15145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FRD49_RS15150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRD49_RS15170	COG2132	Multicopper oxidase
FRD49_RS15180	COG0561	phosphatase activity
FRD49_RS15185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRD49_RS15210	COG1214	PFAM Peptidase M22, glycoprotease
FRD49_RS15260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRD49_RS15270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRD49_RS15275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRD49_RS15280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRD49_RS15340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRD49_RS15350	COG1846	Transcriptional regulator
FRD49_RS15355	COG1764	response to oxidative stress
FRD49_RS15380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRD49_RS15380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRD49_RS15395	COG0037	tRNA processing
FRD49_RS15405	COG0248	Ppx GppA phosphatase
FRD49_RS15435	COG0072	phenylalanine-tRNA ligase activity
FRD49_RS15465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRD49_RS15485	COG1238	metal cluster binding
FRD49_RS15490	COG0625	glutathione transferase activity
FRD49_RS15505	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_RS15510	COG3028	Belongs to the UPF0307 family
FRD49_RS15515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRD49_RS15535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FRD49_RS15540	COG0617	tRNA 3'-terminal CCA addition
FRD49_RS15545	COG1555	photosystem II stabilization
FRD49_RS15550	COG3956	TIGRFAM MazG family protein
FRD49_RS15560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRD49_RS15580	COG0784	Response regulator, receiver
FRD49_RS15580	COG5002	protein histidine kinase activity
FRD49_RS15580	COG2205	protein histidine kinase activity
FRD49_RS15585	COG1024	Enoyl-CoA hydratase
FRD49_RS15590	COG2084	Dehydrogenase
FRD49_RS15595	COG3622	Belongs to the hyi family
FRD49_RS15625	COG0697	spore germination
FRD49_RS15635	COG2814	Major facilitator Superfamily
FRD49_RS15655	COG2132	Multicopper oxidase
FRD49_RS15670	COG2205	protein histidine kinase activity
FRD49_RS15760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRD49_RS15780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FRD49_RS15790	COG0084	hydrolase, TatD family'
FRD49_RS15805	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FRD49_RS15835	COG0440	acetolactate synthase activity
FRD49_RS15840	COG0028	Belongs to the TPP enzyme family
FRD49_RS15865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRD49_RS15870	COG1136	(ABC) transporter
FRD49_RS15870	COG0577	efflux transmembrane transporter activity
FRD49_RS15875	COG1538	Outer membrane efflux protein
FRD49_RS15890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FRD49_RS15895	COG1162	GTPase activity
FRD49_RS15905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FRD49_RS15925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRD49_RS15945	COG1426	Protein conserved in bacteria
FRD49_RS15980	COG0793	Belongs to the peptidase S41A family
FRD49_RS15995	COG2267	carboxylic ester hydrolase activity
FRD49_RS16005	COG1012	belongs to the aldehyde dehydrogenase family
FRD49_RS16010	COG3265	gluconokinase activity
FRD49_RS16020	COG0800	Aldolase
FRD49_RS16030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FRD49_RS16035	COG0857	belongs to the CobB CobQ family
FRD49_RS16035	COG0280	phosphate acetyltransferase
FRD49_RS16040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FRD49_RS16040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FRD49_RS16060	COG0740	serine-type endopeptidase activity
FRD49_RS16070	COG4774	siderophore transport
FRD49_RS16080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRD49_RS16090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRD49_RS16090	COG2813	Specifically methylates the guanine in position
FRD49_RS16195	COG0788	formyltetrahydrofolate deformylase activity
FRD49_RS16220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRD49_RS16220	COG4651	solute:proton antiporter activity
FRD49_RS16240	COG0724	RNA recognition motif
FRD49_RS16245	COG0210	DNA helicase
FRD49_RS16270	COG1733	regulation of RNA biosynthetic process
FRD49_RS16280	COG2900	Belongs to the SlyX family
FRD49_RS16285	COG0488	(ABC) transporter
FRD49_RS16295	COG1280	lysine exporter protein (LysE YggA)
FRD49_RS16300	COG1560	Kdo2-lipid A biosynthetic process
FRD49_RS16310	COG1301	dicarboxylic acid transport
FRD49_RS16365	COG0473	3-isopropylmalate dehydrogenase activity
FRD49_RS16390	COG0583	DNA-binding transcription factor activity
FRD49_RS16435	COG0583	DNA-binding transcription factor activity
FRD49_RS16445	COG0625	glutathione transferase activity
FRD49_RS16450	COG2378	regulation of single-species biofilm formation
FRD49_RS16470	COG1530	ribonuclease E activity
FRD49_RS16475	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_RS16490	COG0583	DNA-binding transcription factor activity
FRD49_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS16500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRD49_RS16510	COG0534	Mate efflux family protein
FRD49_RS16525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRD49_RS16560	COG0493	'glutamate synthase
FRD49_RS16560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRD49_RS16570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FRD49_RS16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRD49_RS16590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRD49_RS16600	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FRD49_RS16600	COG0644	oxidoreductase
FRD49_RS16615	COG4535	Mg2 and Co2 transporter CorC
FRD49_RS16625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRD49_RS16650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRD49_RS16655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRD49_RS16655	COG0475	glutathione-regulated potassium exporter activity
FRD49_RS16660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FRD49_RS16670	COG0484	heat shock protein binding
FRD49_RS16675	COG0789	Transcriptional regulator
FRD49_RS16680	COG0598	Magnesium transport protein CorA
FRD49_RS16685	COG1185	polyribonucleotide nucleotidyltransferase activity
FRD49_RS16695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRD49_RS16700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRD49_RS16705	COG1074	ATP-dependent DNA helicase activity
FRD49_RS16710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FRD49_RS16735	COG2226	methyltransferase
FRD49_RS16745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRD49_RS16760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRD49_RS16775	COG2111	Na H antiporter
FRD49_RS16775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRD49_RS16780	COG1006	Multisubunit Na H antiporter MnhC subunit
FRD49_RS16785	COG0651	ATP synthesis coupled electron transport
FRD49_RS16790	COG1863	multisubunit Na H antiporter MnhE subunit
FRD49_RS16795	COG2212	antiporter activity
FRD49_RS16800	COG1320	monovalent cation:proton antiporter activity
FRD49_RS16805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRD49_RS16815	COG0195	Participates in both transcription termination and antitermination
FRD49_RS16865	COG0237	dephospho-CoA kinase activity
FRD49_RS16875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRD49_RS16890	COG0497	DNA recombination
FRD49_RS16900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRD49_RS16915	COG1289	transmembrane transporter activity
FRD49_RS16930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRD49_RS16930	COG2169	Transcriptional regulator
FRD49_RS16935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRD49_RS16985	COG3545	Serine hydrolase
FRD49_RS17000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FRD49_RS17015	COG0326	Molecular chaperone. Has ATPase activity
FRD49_RS17030	COG2056	Na+-H+ antiporter family
FRD49_RS17035	COG0596	Alpha beta hydrolase
FRD49_RS17135	COG0546	phosphoglycolate phosphatase activity
FRD49_RS17140	COG1716	ATPase activity
FRD49_RS17185	COG0181	hydroxymethylbilane synthase activity
FRD49_RS17195	COG3275	phosphorelay sensor kinase activity
FRD49_RS17215	COG1538	Outer membrane efflux protein
FRD49_RS17245	COG0494	nUDIX hydrolase
FRD49_RS17250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRD49_RS17255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FRD49_RS17260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRD49_RS17265	COG0772	Belongs to the SEDS family
FRD49_RS17290	COG4974	Belongs to the 'phage' integrase family
FRD49_RS17295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRD49_RS17305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRD49_RS17315	COG2197	response regulator
FRD49_RS17330	COG0793	Belongs to the peptidase S41A family
FRD49_RS17335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRD49_RS17340	COG0795	lipopolysaccharide-transporting ATPase activity
FRD49_RS17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRD49_RS17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRD49_RS17390	COG0004	ammonium transporteR
FRD49_RS17395	COG0347	Belongs to the P(II) protein family
FRD49_RS17405	COG0606	chelatase, subunit chli
FRD49_RS17410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRD49_RS17415	COG0235	Class ii aldolase
FRD49_RS17420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRD49_RS17435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRD49_RS17450	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_RS17460	COG0477	Major facilitator Superfamily
FRD49_RS17465	COG2860	membrane
FRD49_RS17475	COG1253	flavin adenine dinucleotide binding
FRD49_RS17485	COG2814	Major facilitator Superfamily
FRD49_RS17495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FRD49_RS17530	COG0655	NAD(P)H dehydrogenase (quinone) activity
FRD49_RS17545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRD49_RS17580	COG1309	transcriptional regulator
FRD49_RS17615	COG0758	DNA mediated transformation
FRD49_RS17625	COG0697	spore germination
FRD49_RS17630	COG1309	transcriptional regulator
FRD49_RS17645	COG0386	Belongs to the glutathione peroxidase family
FRD49_RS17655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRD49_RS17710	COG1121	(ABC) transporter
FRD49_RS17715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRD49_RS17720	COG1280	lysine exporter protein (LysE YggA)
FRD49_RS17725	COG2837	iron assimilation
FRD49_RS17730	COG0281	malic enzyme
FRD49_RS17770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRD49_RS17775	COG0519	Catalyzes the synthesis of GMP from XMP
FRD49_RS17775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRD49_RS17780	COG4399	Belongs to the UPF0754 family
FRD49_RS17785	COG2259	Doxx family
FRD49_RS17790	COG0586	Pfam SNARE associated Golgi protein
FRD49_RS17805	COG1192	Involved in chromosome partitioning
FRD49_RS17815	COG0271	Belongs to the BolA IbaG family
FRD49_RS17860	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS17865	COG0318	PFAM AMP-dependent synthetase and ligase
FRD49_RS17870	COG2197	response regulator
FRD49_RS17880	COG3916	Acyl-homoserine-lactone synthase
FRD49_RS17885	COG0477	Major facilitator Superfamily
FRD49_RS17890	COG1024	Enoyl-CoA hydratase
FRD49_RS17895	COG1024	Enoyl-CoA hydratase
FRD49_RS17900	COG1960	acyl-CoA dehydrogenase activity
FRD49_RS17905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRD49_RS17925	COG1113	amino acid transport
FRD49_RS17930	COG1113	amino acid transport
FRD49_RS17935	COG0251	oxidation-reduction process
FRD49_RS17975	COG0564	pseudouridine synthase activity
FRD49_RS18040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRD49_RS18055	COG1802	Transcriptional regulator
FRD49_RS18065	COG1448	Aminotransferase
FRD49_RS18070	COG0277	FAD linked oxidase domain protein
FRD49_RS18080	COG2186	Transcriptional regulator
FRD49_RS18090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRD49_RS18120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FRD49_RS18125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRD49_RS18150	COG0463	Glycosyl transferase, family 2
FRD49_RS18175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FRD49_RS18180	COG1091	dTDP-4-dehydrorhamnose reductase activity
FRD49_RS18190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FRD49_RS18195	COG1596	polysaccharide export
FRD49_RS18220	COG0728	peptidoglycan biosynthetic process
FRD49_RS18225	COG3023	N-Acetylmuramoyl-L-alanine amidase
FRD49_RS18280	COG0546	phosphoglycolate phosphatase activity
FRD49_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
FRD49_RS18300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRD49_RS18300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FRD49_RS18305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_RS18310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRD49_RS18315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRD49_RS18320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRD49_RS18325	COG1116	anion transmembrane transporter activity
FRD49_RS18330	COG1309	transcriptional regulator
FRD49_RS18335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FRD49_RS18345	COG0196	riboflavin kinase activity
FRD49_RS18350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRD49_RS18360	COG1047	Peptidyl-prolyl cis-trans
FRD49_RS18400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRD49_RS18405	COG0657	acetylesterase activity
FRD49_RS18455	COG2951	lytic endotransglycosylase activity
FRD49_RS18460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRD49_RS18480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRD49_RS18490	COG0671	phosphoesterase, PA-phosphatase related
FRD49_RS18495	COG0861	Integral membrane protein TerC family
FRD49_RS18505	COG0754	glutathionylspermidine amidase activity
FRD49_RS18515	COG0402	S-adenosylhomocysteine deaminase activity
FRD49_RS18530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRD49_RS18535	COG1230	cation diffusion facilitator family transporter
FRD49_RS18550	COG0706	membrane insertase activity
FRD49_RS18610	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
FRD49_RS18620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRD49_RS18650	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FRD49_RS18675	COG2801	Transposase and inactivated derivatives
FRD49_RS18705	COG4221	oxidoreductase activity
FRD49_RS18710	COG0583	DNA-binding transcription factor activity
FRD49_RS18715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FRD49_RS18720	COG3321	synthase
FRD49_RS18720	COG0604	alcohol dehydrogenase
FRD49_RS18730	COG0697	spore germination
FRD49_RS18735	COG0477	Major facilitator Superfamily
FRD49_RS18765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FRD49_RS18780	COG1979	alcohol dehydrogenase
FRD49_RS18790	COG1902	pentaerythritol trinitrate reductase activity
FRD49_RS18800	COG1309	transcriptional regulator
FRD49_RS18805	COG2130	NADP-dependent
FRD49_RS18820	COG0582	viral genome integration into host DNA
FRD49_RS18840	COG3293	Transposase
FRD49_RS18855	COG0542	response to heat
FRD49_RS18885	COG0501	Belongs to the peptidase M48B family
FRD49_RS18890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRD49_RS18930	COG1064	alcohol dehydrogenase
FRD49_RS18985	COG1192	Involved in chromosome partitioning
FRD49_RS19010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs