locus-tag	class	description
H0S59_RS00010	COG0592	DNA-directed DNA polymerase activity
H0S59_RS00020	COG0187	DNA topoisomerase II activity
H0S59_RS00030	COG0586	Pfam SNARE associated Golgi protein
H0S59_RS00035	COG0488	(ABC) transporter
H0S59_RS00060	COG0596	Alpha beta hydrolase
H0S59_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S59_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S59_RS00110	COG1047	Peptidyl-prolyl cis-trans
H0S59_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S59_RS00125	COG0196	riboflavin kinase activity
H0S59_RS00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0S59_RS00140	COG1309	transcriptional regulator
H0S59_RS00145	COG1116	anion transmembrane transporter activity
H0S59_RS00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_RS00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S59_RS00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_RS00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_RS00170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S59_RS00170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0S59_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS00190	COG0546	phosphoglycolate phosphatase activity
H0S59_RS00245	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0S59_RS00250	COG0728	peptidoglycan biosynthetic process
H0S59_RS00275	COG1596	polysaccharide export
H0S59_RS00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S59_RS00290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0S59_RS00305	COG2030	dehydratase
H0S59_RS00320	COG1216	Glycosyl transferase, family 2
H0S59_RS00320	COG0463	Glycosyl transferase, family 2
H0S59_RS00325	COG0438	transferase activity, transferring glycosyl groups
H0S59_RS00325	COG0297	glycogen (starch) synthase activity
H0S59_RS00335	COG1215	transferase activity, transferring glycosyl groups
H0S59_RS00345	COG1216	Glycosyl transferase, family 2
H0S59_RS00350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S59_RS00355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S59_RS00370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S59_RS00400	COG2186	Transcriptional regulator
H0S59_RS00410	COG0277	FAD linked oxidase domain protein
H0S59_RS00415	COG1448	Aminotransferase
H0S59_RS00425	COG1802	Transcriptional regulator
H0S59_RS00440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0S59_RS00540	COG0564	pseudouridine synthase activity
H0S59_RS00580	COG0251	oxidation-reduction process
H0S59_RS00585	COG1113	amino acid transport
H0S59_RS00590	COG1113	amino acid transport
H0S59_RS00610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S59_RS00615	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS00620	COG1024	Enoyl-CoA hydratase
H0S59_RS00625	COG1024	Enoyl-CoA hydratase
H0S59_RS00630	COG0477	Major facilitator Superfamily
H0S59_RS00635	COG3916	Acyl-homoserine-lactone synthase
H0S59_RS00645	COG2197	response regulator
H0S59_RS00650	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_RS00655	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS00700	COG0271	Belongs to the BolA IbaG family
H0S59_RS00710	COG1192	Involved in chromosome partitioning
H0S59_RS00725	COG0586	Pfam SNARE associated Golgi protein
H0S59_RS00730	COG2259	Doxx family
H0S59_RS00735	COG4399	Belongs to the UPF0754 family
H0S59_RS00740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S59_RS00740	COG0519	Catalyzes the synthesis of GMP from XMP
H0S59_RS00745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S59_RS00755	COG0735	belongs to the Fur family
H0S59_RS00790	COG0281	malic enzyme
H0S59_RS00795	COG2837	iron assimilation
H0S59_RS00800	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S59_RS00810	COG1121	(ABC) transporter
H0S59_RS00865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0S59_RS00875	COG0386	Belongs to the glutathione peroxidase family
H0S59_RS00890	COG1309	transcriptional regulator
H0S59_RS00895	COG0697	spore germination
H0S59_RS00905	COG0758	DNA mediated transformation
H0S59_RS00940	COG1309	transcriptional regulator
H0S59_RS00975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S59_RS00990	COG0655	NAD(P)H dehydrogenase (quinone) activity
H0S59_RS01025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S59_RS01035	COG2814	Major facilitator Superfamily
H0S59_RS01045	COG1253	flavin adenine dinucleotide binding
H0S59_RS01055	COG2860	membrane
H0S59_RS01060	COG0477	Major facilitator Superfamily
H0S59_RS01070	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_RS01085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S59_RS01100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_RS01105	COG0235	Class ii aldolase
H0S59_RS01110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_RS01115	COG0606	chelatase, subunit chli
H0S59_RS01165	COG2205	protein histidine kinase activity
H0S59_RS01180	COG2132	Multicopper oxidase
H0S59_RS01225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_RS01250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0S59_RS01280	COG0606	chelatase, subunit chli
H0S59_RS01290	COG0347	Belongs to the P(II) protein family
H0S59_RS01295	COG0004	ammonium transporteR
H0S59_RS01305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S59_RS01305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S59_RS01345	COG0795	lipopolysaccharide-transporting ATPase activity
H0S59_RS01350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S59_RS01355	COG0793	Belongs to the peptidase S41A family
H0S59_RS01370	COG2197	response regulator
H0S59_RS01380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S59_RS01390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S59_RS01395	COG4974	Belongs to the 'phage' integrase family
H0S59_RS01420	COG0772	Belongs to the SEDS family
H0S59_RS01425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S59_RS01430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S59_RS01435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S59_RS01440	COG0494	nUDIX hydrolase
H0S59_RS01460	COG0697	spore germination
H0S59_RS01465	COG1538	Outer membrane efflux protein
H0S59_RS01485	COG3275	phosphorelay sensor kinase activity
H0S59_RS01495	COG0181	hydroxymethylbilane synthase activity
H0S59_RS01540	COG1716	ATPase activity
H0S59_RS01545	COG0546	phosphoglycolate phosphatase activity
H0S59_RS01640	COG0596	Alpha beta hydrolase
H0S59_RS01645	COG2056	Na+-H+ antiporter family
H0S59_RS01660	COG0326	Molecular chaperone. Has ATPase activity
H0S59_RS01675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S59_RS01690	COG3545	Serine hydrolase
H0S59_RS01735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S59_RS01740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S59_RS01740	COG2169	Transcriptional regulator
H0S59_RS01755	COG1289	transmembrane transporter activity
H0S59_RS01770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S59_RS01780	COG0497	DNA recombination
H0S59_RS01795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S59_RS01805	COG0237	dephospho-CoA kinase activity
H0S59_RS01850	COG0195	Participates in both transcription termination and antitermination
H0S59_RS01860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0S59_RS01865	COG1320	monovalent cation:proton antiporter activity
H0S59_RS01870	COG2212	antiporter activity
H0S59_RS01875	COG1863	multisubunit Na H antiporter MnhE subunit
H0S59_RS01880	COG0651	ATP synthesis coupled electron transport
H0S59_RS01885	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S59_RS01890	COG2111	Na H antiporter
H0S59_RS01890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S59_RS01905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S59_RS01915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S59_RS01925	COG2226	methyltransferase
H0S59_RS01950	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S59_RS01955	COG1074	ATP-dependent DNA helicase activity
H0S59_RS01960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S59_RS01965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S59_RS01975	COG1185	polyribonucleotide nucleotidyltransferase activity
H0S59_RS01980	COG0598	Magnesium transport protein CorA
H0S59_RS01985	COG0789	Transcriptional regulator
H0S59_RS01990	COG0484	heat shock protein binding
H0S59_RS02000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0S59_RS02005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S59_RS02005	COG0475	glutathione-regulated potassium exporter activity
H0S59_RS02010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S59_RS02035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S59_RS02045	COG4535	Mg2 and Co2 transporter CorC
H0S59_RS02060	COG0644	oxidoreductase
H0S59_RS02060	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S59_RS02070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S59_RS02085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_RS02090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S59_RS02100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S59_RS02100	COG0493	'glutamate synthase
H0S59_RS02130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S59_RS02145	COG0534	Mate efflux family protein
H0S59_RS02155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S59_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS02165	COG0583	DNA-binding transcription factor activity
H0S59_RS02180	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_RS02185	COG1530	ribonuclease E activity
H0S59_RS02200	COG2378	regulation of single-species biofilm formation
H0S59_RS02205	COG0625	glutathione transferase activity
H0S59_RS02215	COG0583	DNA-binding transcription factor activity
H0S59_RS02285	COG0473	3-isopropylmalate dehydrogenase activity
H0S59_RS02340	COG1301	dicarboxylic acid transport
H0S59_RS02350	COG1560	Kdo2-lipid A biosynthetic process
H0S59_RS02355	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS02365	COG0488	(ABC) transporter
H0S59_RS02370	COG2900	Belongs to the SlyX family
H0S59_RS02380	COG1733	regulation of RNA biosynthetic process
H0S59_RS02405	COG0210	DNA helicase
H0S59_RS02410	COG0724	RNA recognition motif
H0S59_RS02430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S59_RS02430	COG4651	solute:proton antiporter activity
H0S59_RS02455	COG0788	formyltetrahydrofolate deformylase activity
H0S59_RS02560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S59_RS02560	COG2813	Specifically methylates the guanine in position
H0S59_RS02570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S59_RS02580	COG4774	siderophore transport
H0S59_RS02590	COG0740	serine-type endopeptidase activity
H0S59_RS02610	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S59_RS02610	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S59_RS02615	COG0857	belongs to the CobB CobQ family
H0S59_RS02615	COG0280	phosphate acetyltransferase
H0S59_RS02620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S59_RS02630	COG0800	Aldolase
H0S59_RS02640	COG3265	gluconokinase activity
H0S59_RS02645	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS02655	COG2267	carboxylic ester hydrolase activity
H0S59_RS02670	COG0793	Belongs to the peptidase S41A family
H0S59_RS02705	COG1426	Protein conserved in bacteria
H0S59_RS02725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S59_RS02750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S59_RS02760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0S59_RS02765	COG1216	Glycosyl transferase, family 2
H0S59_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS02820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0S59_RS02840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S59_RS02850	COG1162	GTPase activity
H0S59_RS02855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S59_RS02870	COG1538	Outer membrane efflux protein
H0S59_RS02875	COG1136	(ABC) transporter
H0S59_RS02875	COG0577	efflux transmembrane transporter activity
H0S59_RS02880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS02905	COG0028	Belongs to the TPP enzyme family
H0S59_RS02910	COG0440	acetolactate synthase activity
H0S59_RS02945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S59_RS02960	COG0084	hydrolase, TatD family'
H0S59_RS02970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S59_RS02990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S59_RS02995	COG2814	Major facilitator Superfamily
H0S59_RS03005	COG0697	spore germination
H0S59_RS03035	COG3622	Belongs to the hyi family
H0S59_RS03040	COG2084	Dehydrogenase
H0S59_RS03045	COG1024	Enoyl-CoA hydratase
H0S59_RS03050	COG0784	Response regulator, receiver
H0S59_RS03050	COG5002	protein histidine kinase activity
H0S59_RS03050	COG2205	protein histidine kinase activity
H0S59_RS03070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S59_RS03080	COG3956	TIGRFAM MazG family protein
H0S59_RS03085	COG1555	photosystem II stabilization
H0S59_RS03090	COG0617	tRNA 3'-terminal CCA addition
H0S59_RS03095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S59_RS03115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S59_RS03120	COG3028	Belongs to the UPF0307 family
H0S59_RS03125	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_RS03140	COG0625	glutathione transferase activity
H0S59_RS03145	COG1238	metal cluster binding
H0S59_RS03155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0S59_RS03185	COG0072	phenylalanine-tRNA ligase activity
H0S59_RS03215	COG0248	Ppx GppA phosphatase
H0S59_RS03225	COG0037	tRNA processing
H0S59_RS03240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S59_RS03240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S59_RS03265	COG1764	response to oxidative stress
H0S59_RS03270	COG1846	Transcriptional regulator
H0S59_RS03280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S59_RS03340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0S59_RS03345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S59_RS03350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S59_RS03360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0S59_RS03410	COG1214	PFAM Peptidase M22, glycoprotease
H0S59_RS03435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S59_RS03440	COG0561	phosphatase activity
H0S59_RS03450	COG2132	Multicopper oxidase
H0S59_RS03470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S59_RS03475	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S59_RS03480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S59_RS03510	COG1063	alcohol dehydrogenase
H0S59_RS03515	COG0583	DNA-binding transcription factor activity
H0S59_RS03520	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS03525	COG2814	Major facilitator Superfamily
H0S59_RS03530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S59_RS03535	COG1309	transcriptional regulator
H0S59_RS03550	COG1053	succinate dehydrogenase
H0S59_RS03555	COG0583	DNA-binding transcription factor activity
H0S59_RS03570	COG0583	DNA-binding transcription factor activity
H0S59_RS03590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_RS03595	COG1309	transcriptional regulator
H0S59_RS03645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S59_RS03665	COG0745	RESPONSE REGULATOR receiver
H0S59_RS03680	COG3706	GGDEF domain
H0S59_RS03705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S59_RS03735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S59_RS03740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S59_RS03765	COG0583	DNA-binding transcription factor activity
H0S59_RS03785	COG0668	transmembrane transport
H0S59_RS03795	COG2081	HI0933 family
H0S59_RS03800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S59_RS03835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S59_RS03835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S59_RS03845	COG0489	protein tyrosine kinase activity
H0S59_RS03895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S59_RS03905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S59_RS03920	COG0730	response to heat
H0S59_RS03930	COG1196	nuclear chromosome segregation
H0S59_RS03950	COG2223	nitrite transmembrane transporter activity
H0S59_RS03955	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0S59_RS03960	COG1877	trehalose-phosphatase activity
H0S59_RS03965	COG0596	Alpha beta hydrolase
H0S59_RS03965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S59_RS03965	COG2226	methyltransferase
H0S59_RS03980	COG4106	trans-aconitate 2-methyltransferase activity
H0S59_RS03995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S59_RS04000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S59_RS04005	COG0009	L-threonylcarbamoyladenylate synthase
H0S59_RS04010	COG3101	peptidyl-lysine hydroxylation
H0S59_RS04015	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S59_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS04040	COG1652	LysM domain
H0S59_RS04045	COG0351	phosphomethylpyrimidine kinase
H0S59_RS04045	COG0352	thiamine-phosphate diphosphorylase activity
H0S59_RS04045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S59_RS04055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S59_RS04085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S59_RS04115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0S59_RS04130	COG0358	DNA primase activity
H0S59_RS04330	COG3728	DNA packaging
H0S59_RS04420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S59_RS04445	COG0582	viral genome integration into host DNA
H0S59_RS04455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S59_RS04475	COG0583	DNA-binding transcription factor activity
H0S59_RS04480	COG0473	3-isopropylmalate dehydrogenase activity
H0S59_RS04490	COG0657	acetylesterase activity
H0S59_RS04495	COG4638	Rieske (2fe-2S)
H0S59_RS04500	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS04520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0S59_RS04520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S59_RS04535	COG1981	membrane
H0S59_RS04550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S59_RS04580	COG0456	acetyltransferase
H0S59_RS04590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S59_RS04595	COG0492	ferredoxin-NADP+ reductase activity
H0S59_RS04600	COG1674	ftsk spoiiie
H0S59_RS04605	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS04625	COG2894	cell division
H0S59_RS04640	COG0204	Acyl-transferase
H0S59_RS04645	COG2885	chlorophyll binding
H0S59_RS04650	COG0210	DNA helicase
H0S59_RS04660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S59_RS04675	COG0121	glutamine amidotransferase
H0S59_RS04695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S59_RS04700	COG0735	belongs to the Fur family
H0S59_RS04720	COG1968	undecaprenyl-diphosphatase activity
H0S59_RS04730	COG0420	3'-5' exonuclease activity
H0S59_RS04750	COG1090	epimerase
H0S59_RS04765	COG2050	protein possibly involved in aromatic compounds catabolism
H0S59_RS04775	COG2814	Major facilitator Superfamily
H0S59_RS04780	COG0405	Gamma-glutamyltransferase
H0S59_RS04825	COG0477	Major facilitator Superfamily
H0S59_RS04830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_RS04880	COG0531	amino acid
H0S59_RS04885	COG2040	homocysteine
H0S59_RS04910	COG1309	transcriptional regulator
H0S59_RS04915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S59_RS04920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S59_RS04930	COG1607	acyl-coa hydrolase
H0S59_RS04940	COG0523	cobalamin synthesis protein
H0S59_RS04950	COG4681	YaeQ
H0S59_RS04960	COG0726	polysaccharide deacetylase
H0S59_RS04960	COG1649	PFAM Uncharacterised BCR, COG1649
H0S59_RS04965	COG1215	transferase activity, transferring glycosyl groups
H0S59_RS04975	COG1024	Enoyl-CoA hydratase
H0S59_RS05000	COG1414	Transcriptional regulator
H0S59_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S59_RS05035	COG2271	Major facilitator Superfamily
H0S59_RS05045	COG2267	carboxylic ester hydrolase activity
H0S59_RS05050	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS05065	COG0028	Belongs to the TPP enzyme family
H0S59_RS05075	COG0477	Major facilitator Superfamily
H0S59_RS05080	COG0242	peptide deformylase activity
H0S59_RS05085	COG2066	Belongs to the glutaminase family
H0S59_RS05090	COG2207	Transcriptional regulator
H0S59_RS05090	COG0662	Cupin 2, conserved barrel domain protein
H0S59_RS05095	COG2223	nitrite transmembrane transporter activity
H0S59_RS05125	COG0306	phosphate transporter
H0S59_RS05145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S59_RS05190	COG4181	ATPase activity
H0S59_RS05195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S59_RS05220	COG0583	DNA-binding transcription factor activity
H0S59_RS05230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_RS05235	COG1773	rubredoxin
H0S59_RS05285	COG2851	Citrate transporter
H0S59_RS05290	COG1253	flavin adenine dinucleotide binding
H0S59_RS05335	COG0804	urea catabolic process
H0S59_RS05345	COG0830	nickel cation binding
H0S59_RS05365	COG0742	ribosomal rna small subunit methyltransferase
H0S59_RS05370	COG0768	penicillin binding
H0S59_RS05395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S59_RS05400	COG2878	Part of a membrane complex involved in electron transport
H0S59_RS05405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S59_RS05415	COG3384	dioxygenase
H0S59_RS05465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S59_RS05500	COG0006	proline dipeptidase activity
H0S59_RS05505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_RS05510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_RS05530	COG1279	arginine transmembrane transporter activity
H0S59_RS05535	COG0583	DNA-binding transcription factor activity
H0S59_RS05580	COG1388	LysM domain
H0S59_RS05580	COG0741	lytic transglycosylase activity
H0S59_RS05580	COG0741	lytic transglycosylase activity
H0S59_RS05580	COG1388	LysM domain
H0S59_RS05590	COG4174	ABC transporter (Permease)
H0S59_RS05595	COG4239	(ABC) transporter, permease
H0S59_RS05600	COG4172	Belongs to the ABC transporter superfamily
H0S59_RS05630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S59_RS05640	COG4251	negative regulation of phosphorylation
H0S59_RS05640	COG5001	Diguanylate cyclase
H0S59_RS05640	COG3706	GGDEF domain
H0S59_RS05640	COG2203	Gaf domain
H0S59_RS05655	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S59_RS05655	COG1902	pentaerythritol trinitrate reductase activity
H0S59_RS05665	COG0582	viral genome integration into host DNA
H0S59_RS05680	COG2161	toxin-antitoxin pair type II binding
H0S59_RS05715	COG4372	Transposase
H0S59_RS05750	COG1309	transcriptional regulator
H0S59_RS05855	COG1113	amino acid transport
H0S59_RS05865	COG0531	amino acid
H0S59_RS05885	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS05905	COG1113	amino acid transport
H0S59_RS05925	COG0697	spore germination
H0S59_RS05945	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS05955	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS05960	COG1024	Enoyl-CoA hydratase
H0S59_RS05965	COG2814	Major facilitator Superfamily
H0S59_RS05980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_RS06000	COG1944	ATP diphosphatase activity
H0S59_RS06030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H0S59_RS06035	COG2072	flavoprotein involved in K transport
H0S59_RS06050	COG1309	transcriptional regulator
H0S59_RS06055	COG1741	Belongs to the pirin family
H0S59_RS06070	COG2072	flavoprotein involved in K transport
H0S59_RS06080	COG2252	PERMEase
H0S59_RS06085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S59_RS06090	COG3038	cytochrome b561
H0S59_RS06100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S59_RS06110	COG0527	aspartate kinase activity
H0S59_RS06130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S59_RS06145	COG0667	Aldo Keto reductase
H0S59_RS06155	COG1765	OsmC-like protein
H0S59_RS06170	COG0542	response to heat
H0S59_RS06205	COG2885	chlorophyll binding
H0S59_RS06215	COG0625	glutathione transferase activity
H0S59_RS06220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S59_RS06240	COG3634	alkyl hydroperoxide reductase activity
H0S59_RS06260	COG0450	alkyl hydroperoxide reductase
H0S59_RS06265	COG1643	Atp-dependent helicase
H0S59_RS06280	COG2814	Major facilitator Superfamily
H0S59_RS06285	COG3135	benzoate transporter
H0S59_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS06295	COG0543	2 iron, 2 sulfur cluster binding
H0S59_RS06295	COG0633	Ferredoxin
H0S59_RS06300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S59_RS06305	COG4638	Rieske (2fe-2S)
H0S59_RS06310	COG0583	DNA-binding transcription factor activity
H0S59_RS06320	COG2871	sodium ion transport
H0S59_RS06405	COG1570	exodeoxyribonuclease VII activity
H0S59_RS06435	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS06515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S59_RS06515	COG0517	IMP dehydrogenase activity
H0S59_RS06520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S59_RS06530	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S59_RS06535	COG1137	ATPase activity
H0S59_RS06540	COG1538	Outer membrane efflux protein
H0S59_RS06570	COG4122	O-methyltransferase activity
H0S59_RS06580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S59_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS06615	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS06665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS06670	COG0653	protein targeting
H0S59_RS06695	COG2814	Major facilitator Superfamily
H0S59_RS06715	COG4774	siderophore transport
H0S59_RS06720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S59_RS06750	COG1522	sequence-specific DNA binding
H0S59_RS06760	COG0626	cystathionine gamma-synthase activity
H0S59_RS06770	COG1278	Cold shock
H0S59_RS06775	COG0789	Transcriptional regulator
H0S59_RS06790	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S59_RS06810	COG1011	Hydrolase
H0S59_RS06870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S59_RS06875	COG3713	MltA-interacting MipA family protein
H0S59_RS06890	COG2076	Multidrug Resistance protein
H0S59_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS06920	COG3220	belongs to the UPF0276 family
H0S59_RS06930	COG1595	DNA-templated transcription, initiation
H0S59_RS06940	COG0583	DNA-binding transcription factor activity
H0S59_RS06945	COG1914	H( )-stimulated, divalent metal cation uptake system
H0S59_RS06965	COG4770	biotin carboxylase activity
H0S59_RS06970	COG0038	chloride channel
H0S59_RS06975	COG1196	nuclear chromosome segregation
H0S59_RS07000	COG1063	alcohol dehydrogenase
H0S59_RS07015	COG0439	Biotin carboxylase
H0S59_RS07020	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_RS07025	COG1733	regulation of RNA biosynthetic process
H0S59_RS07035	COG0864	Transcriptional regulator
H0S59_RS07045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_RS07050	COG1116	anion transmembrane transporter activity
H0S59_RS07065	COG0477	Major facilitator Superfamily
H0S59_RS07125	COG2885	chlorophyll binding
H0S59_RS07170	COG0590	tRNA wobble adenosine to inosine editing
H0S59_RS07175	COG2807	transmembrane transport
H0S59_RS07190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0S59_RS07200	COG0789	Transcriptional regulator
H0S59_RS07210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_RS07230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S59_RS07255	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS07260	COG0531	amino acid
H0S59_RS07265	COG1760	l-serine dehydratase
H0S59_RS07270	COG2030	dehydratase
H0S59_RS07270	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS07275	COG3396	Phenylacetate-CoA oxygenase
H0S59_RS07280	COG3460	Phenylacetate-CoA oxygenase
H0S59_RS07285	COG3396	Phenylacetate-CoA oxygenase
H0S59_RS07290	COG2151	metal-sulfur cluster biosynthetic enzyme
H0S59_RS07295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_RS07300	COG1024	Enoyl-CoA hydratase
H0S59_RS07305	COG1024	Enoyl-CoA hydratase
H0S59_RS07310	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S59_RS07315	COG0183	Belongs to the thiolase family
H0S59_RS07320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0S59_RS07325	COG3327	negative regulation of DNA-templated transcription, initiation
H0S59_RS07335	COG2050	protein possibly involved in aromatic compounds catabolism
H0S59_RS07355	COG1733	regulation of RNA biosynthetic process
H0S59_RS07360	COG0753	catalase activity
H0S59_RS07365	COG3038	cytochrome b561
H0S59_RS07385	COG2267	carboxylic ester hydrolase activity
H0S59_RS07390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_RS07395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S59_RS07400	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS07410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0S59_RS07420	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS07425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S59_RS07430	COG0583	DNA-binding transcription factor activity
H0S59_RS07440	COG1414	Transcriptional regulator
H0S59_RS07445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_RS07455	COG1840	ABC-type Fe3 transport system, periplasmic component
H0S59_RS07460	COG3842	ATPase activity
H0S59_RS07475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H0S59_RS07480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S59_RS07485	COG2814	Major facilitator Superfamily
H0S59_RS07490	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS07505	COG1024	Enoyl-CoA hydratase
H0S59_RS07515	COG2814	Major facilitator Superfamily
H0S59_RS07525	COG0183	Belongs to the thiolase family
H0S59_RS07530	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S59_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS07540	COG1024	Enoyl-CoA hydratase
H0S59_RS07545	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS07550	COG2814	Major facilitator Superfamily
H0S59_RS07555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S59_RS07560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S59_RS07570	COG2814	Major facilitator Superfamily
H0S59_RS07580	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS07595	COG0583	DNA-binding transcription factor activity
H0S59_RS07605	COG4770	biotin carboxylase activity
H0S59_RS07610	COG1024	Enoyl-CoA hydratase
H0S59_RS07615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S59_RS07620	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS07625	COG1309	transcriptional regulator
H0S59_RS07630	COG0318	PFAM AMP-dependent synthetase and ligase
H0S59_RS07650	COG0583	DNA-binding transcription factor activity
H0S59_RS07700	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS07740	COG2205	protein histidine kinase activity
H0S59_RS07740	COG0784	Response regulator, receiver
H0S59_RS07760	COG0765	amino acid transport
H0S59_RS07765	COG0765	amino acid transport
H0S59_RS07770	COG1126	abc transporter atp-binding protein
H0S59_RS07775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_RS07780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_RS07795	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS07800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0S59_RS07805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S59_RS07810	COG1045	serine acetyltransferase
H0S59_RS07825	COG0583	DNA-binding transcription factor activity
H0S59_RS07830	COG0625	glutathione transferase activity
H0S59_RS07835	COG0625	glutathione transferase activity
H0S59_RS07840	COG0583	DNA-binding transcription factor activity
H0S59_RS07850	COG1346	cytolysis
H0S59_RS07855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_RS07870	COG2814	Major facilitator Superfamily
H0S59_RS07880	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H0S59_RS07885	COG3052	prosthetic group binding
H0S59_RS07905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0S59_RS07925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_RS07935	COG1294	oxidase, subunit
H0S59_RS07940	COG1271	oxidase subunit
H0S59_RS07960	COG0477	Major facilitator Superfamily
H0S59_RS07970	COG4521	taurine ABC transporter
H0S59_RS07975	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H0S59_RS07980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_RS07985	COG2175	clavaminate synthase activity
H0S59_RS07995	COG1953	Uracil, thiamine, allantoin
H0S59_RS08005	COG0583	DNA-binding transcription factor activity
H0S59_RS08015	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0S59_RS08030	COG0640	Transcriptional regulator
H0S59_RS08035	COG0798	PFAM Bile acid sodium symporter
H0S59_RS08040	COG0583	DNA-binding transcription factor activity
H0S59_RS08055	COG3634	alkyl hydroperoxide reductase activity
H0S59_RS08090	COG1301	dicarboxylic acid transport
H0S59_RS08095	COG0436	Aminotransferase
H0S59_RS08105	COG0386	Belongs to the glutathione peroxidase family
H0S59_RS08115	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS08145	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S59_RS08170	COG0012	GTP binding
H0S59_RS08175	COG2011	ABC-type metal ion transport system permease component
H0S59_RS08180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S59_RS08185	COG1464	Belongs to the NlpA lipoprotein family
H0S59_RS08190	COG1464	Belongs to the NlpA lipoprotein family
H0S59_RS08220	COG0765	amino acid transport
H0S59_RS08225	COG0765	amino acid transport
H0S59_RS08230	COG1126	abc transporter atp-binding protein
H0S59_RS08240	COG1522	sequence-specific DNA binding
H0S59_RS08255	COG1309	transcriptional regulator
H0S59_RS08275	COG0583	DNA-binding transcription factor activity
H0S59_RS08285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0S59_RS08295	COG0697	spore germination
H0S59_RS08320	COG3121	Chaperone
H0S59_RS08325	COG3539	Fimbrial protein
H0S59_RS08350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S59_RS08350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S59_RS08390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S59_RS08400	COG2353	YceI-like domain
H0S59_RS08410	COG3698	Phosphodiester glycosidase
H0S59_RS08425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H0S59_RS08430	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S59_RS08430	COG0506	proline dehydrogenase activity
H0S59_RS08430	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S59_RS08440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S59_RS08445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0S59_RS08465	COG1132	(ABC) transporter
H0S59_RS08470	COG3122	Protein conserved in bacteria
H0S59_RS08475	COG3619	membrane
H0S59_RS08485	COG0640	Transcriptional regulator
H0S59_RS08495	COG2850	peptidyl-arginine hydroxylation
H0S59_RS08500	COG0424	maF-like protein
H0S59_RS08520	COG0191	fructose-bisphosphate aldolase activity
H0S59_RS08525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S59_RS08540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S59_RS08550	COG1192	Involved in chromosome partitioning
H0S59_RS08555	COG1475	DNA binding
H0S59_RS08560	COG0811	peptide transport
H0S59_RS08570	COG1132	(ABC) transporter
H0S59_RS08575	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S59_RS08595	COG0084	hydrolase, TatD family'
H0S59_RS08660	COG0776	regulation of translation
H0S59_RS08675	COG2431	L-lysine efflux transmembrane transporter activity
H0S59_RS08690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S59_RS08695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S59_RS08720	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H0S59_RS08745	COG0339	signal peptide processing
H0S59_RS08750	COG0601	transmembrane transport
H0S59_RS08755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0S59_RS08760	COG4172	Belongs to the ABC transporter superfamily
H0S59_RS08790	COG0702	epimerase
H0S59_RS08795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S59_RS08815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S59_RS08845	COG0316	Belongs to the HesB IscA family
H0S59_RS08850	COG0822	iron-sulfur transferase activity
H0S59_RS08875	COG0776	regulation of translation
H0S59_RS08880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S59_RS08885	COG2207	Transcriptional regulator
H0S59_RS08890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_RS08895	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS08900	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS08915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S59_RS08920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S59_RS08935	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0S59_RS08940	COG0406	alpha-ribazole phosphatase activity
H0S59_RS08955	COG4772	TonB-dependent receptor
H0S59_RS08965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S59_RS08970	COG0730	response to heat
H0S59_RS08990	COG4773	Receptor
H0S59_RS08995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S59_RS09010	COG1131	(ABC) transporter
H0S59_RS09015	COG0842	Transport permease protein
H0S59_RS09020	COG0842	Transport permease protein
H0S59_RS09075	COG2226	methyltransferase
H0S59_RS09100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S59_RS09135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S59_RS09145	COG0133	tryptophan synthase activity
H0S59_RS09175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S59_RS09180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0S59_RS09185	COG0022	dehydrogenase e1 component
H0S59_RS09190	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S59_RS09195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S59_RS09205	COG1063	alcohol dehydrogenase
H0S59_RS09210	COG3781	membrane
H0S59_RS09220	COG3453	Protein conserved in bacteria
H0S59_RS09220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_RS09230	COG0730	response to heat
H0S59_RS09245	COG2207	Transcriptional regulator
H0S59_RS09245	COG3708	Transcriptional regulator
H0S59_RS09255	COG2188	Transcriptional regulator
H0S59_RS09270	COG4521	taurine ABC transporter
H0S59_RS09275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_RS09295	COG0477	Major facilitator Superfamily
H0S59_RS09305	COG1027	Aspartate ammonia-lyase
H0S59_RS09320	COG0583	DNA-binding transcription factor activity
H0S59_RS09325	COG0583	DNA-binding transcription factor activity
H0S59_RS09330	COG0183	Belongs to the thiolase family
H0S59_RS09335	COG2031	fatty acid transporter
H0S59_RS09350	COG0583	DNA-binding transcription factor activity
H0S59_RS09375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_RS09380	COG2610	gluconate transmembrane transporter activity
H0S59_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS09390	COG2207	Transcriptional regulator
H0S59_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS09415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_RS09430	COG0543	2 iron, 2 sulfur cluster binding
H0S59_RS09430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_RS09435	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S59_RS09440	COG4638	Rieske (2fe-2S)
H0S59_RS09450	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S59_RS09455	COG4149	molybdate abc transporter
H0S59_RS09460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0S59_RS09490	COG3251	PFAM MbtH domain protein
H0S59_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS09505	COG1169	isochorismate synthase
H0S59_RS09510	COG1021	2,3-dihydroxybenzoate-AMP ligase
H0S59_RS09515	COG3433	isochorismatase activity
H0S59_RS09515	COG1535	isochorismatase
H0S59_RS09525	COG4771	TonB-dependent receptor
H0S59_RS09590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S59_RS09605	COG0753	catalase activity
H0S59_RS09615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S59_RS09640	COG3539	Fimbrial protein
H0S59_RS09650	COG1538	Outer membrane efflux protein
H0S59_RS09655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_RS09660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS09665	COG0745	RESPONSE REGULATOR receiver
H0S59_RS09670	COG2205	protein histidine kinase activity
H0S59_RS09675	COG3328	transposase activity
H0S59_RS09685	COG1309	transcriptional regulator
H0S59_RS09700	COG0583	DNA-binding transcription factor activity
H0S59_RS09705	COG1073	alpha beta
H0S59_RS09710	COG4221	oxidoreductase activity
H0S59_RS09715	COG1064	alcohol dehydrogenase
H0S59_RS09755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0S59_RS09820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S59_RS09840	COG1120	ATPase activity
H0S59_RS09845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0S59_RS09855	COG2084	Dehydrogenase
H0S59_RS09865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S59_RS09870	COG0583	DNA-binding transcription factor activity
H0S59_RS09880	COG0129	dihydroxy-acid dehydratase activity
H0S59_RS09885	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS09900	COG1566	PFAM secretion protein HlyD family protein
H0S59_RS09915	COG0583	DNA-binding transcription factor activity
H0S59_RS09920	COG2188	Transcriptional regulator
H0S59_RS09950	COG2831	hemolysin activation secretion protein
H0S59_RS09955	COG1309	transcriptional regulator
H0S59_RS09980	COG1309	transcriptional regulator
H0S59_RS09995	COG0789	Transcriptional regulator
H0S59_RS10005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0S59_RS10030	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS10050	COG2186	Transcriptional regulator
H0S59_RS10060	COG0583	DNA-binding transcription factor activity
H0S59_RS10065	COG4948	Mandelate Racemase Muconate Lactonizing
H0S59_RS10070	COG4829	muconolactone delta-isomerase
H0S59_RS10080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S59_RS10085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S59_RS10090	COG0183	Belongs to the thiolase family
H0S59_RS10095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S59_RS10100	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS10110	COG3733	amine oxidase
H0S59_RS10120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_RS10130	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS10140	COG4638	Rieske (2fe-2S)
H0S59_RS10160	COG0154	amidase activity
H0S59_RS10170	COG2814	Major facilitator Superfamily
H0S59_RS10195	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS10200	COG0583	DNA-binding transcription factor activity
H0S59_RS10205	COG1414	Transcriptional regulator
H0S59_RS10220	COG2391	methyltransferase activity
H0S59_RS10230	COG4993	Dehydrogenase
H0S59_RS10235	COG3659	wide pore channel activity
H0S59_RS10240	COG3420	alginic acid biosynthetic process
H0S59_RS10245	COG0710	3-dehydroquinate dehydratase activity
H0S59_RS10250	COG3485	protocatechuate 3,4-dioxygenase
H0S59_RS10255	COG3485	protocatechuate 3,4-dioxygenase
H0S59_RS10260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S59_RS10265	COG2271	Major facilitator Superfamily
H0S59_RS10270	COG0596	Alpha beta hydrolase
H0S59_RS10275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0S59_RS10280	COG0183	Belongs to the thiolase family
H0S59_RS10285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S59_RS10290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S59_RS10300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H0S59_RS10310	COG2323	membrane
H0S59_RS10350	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S59_RS10350	COG1902	pentaerythritol trinitrate reductase activity
H0S59_RS10375	COG0542	response to heat
H0S59_RS10380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S59_RS10410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S59_RS10415	COG0569	domain protein
H0S59_RS10420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S59_RS10435	COG4774	siderophore transport
H0S59_RS10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S59_RS10450	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S59_RS10465	COG1294	oxidase, subunit
H0S59_RS10470	COG4890	Cyd operon protein YbgT
H0S59_RS10485	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H0S59_RS10495	COG0552	protein localization to endoplasmic reticulum
H0S59_RS10520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S59_RS10520	COG0517	IMP dehydrogenase activity
H0S59_RS10525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S59_RS10530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S59_RS10540	COG0583	DNA-binding transcription factor activity
H0S59_RS10545	COG0024	Methionine aminopeptidase
H0S59_RS10575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S59_RS10575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0S59_RS10580	COG1105	Belongs to the carbohydrate kinase PfkB family
H0S59_RS10585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0S59_RS10585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0S59_RS10585	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H0S59_RS10600	COG5001	Diguanylate cyclase
H0S59_RS10600	COG3300	MHYT domain
H0S59_RS10615	COG2135	peptidase activity
H0S59_RS10625	COG3328	transposase activity
H0S59_RS10640	COG4372	Transposase
H0S59_RS10660	COG1113	amino acid transport
H0S59_RS10670	COG1522	sequence-specific DNA binding
H0S59_RS10690	COG1011	Hydrolase
H0S59_RS10695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S59_RS10705	COG2137	regulation of response to DNA damage stimulus
H0S59_RS10720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S59_RS10755	COG0575	Belongs to the CDS family
H0S59_RS10760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S59_RS10785	COG3852	Histidine kinase
H0S59_RS10790	COG2204	response regulator
H0S59_RS10845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S59_RS10850	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0S59_RS10870	COG0697	spore germination
H0S59_RS10875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_RS10885	COG0303	'Molybdopterin
H0S59_RS10890	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S59_RS10890	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S59_RS10905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S59_RS10910	COG0243	molybdopterin cofactor binding
H0S59_RS10920	COG0243	molybdopterin cofactor binding
H0S59_RS10925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_RS10930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_RS10930	COG2146	nitrite reductase [NAD(P)H] activity
H0S59_RS10940	COG0745	RESPONSE REGULATOR receiver
H0S59_RS10945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_RS10945	COG1116	anion transmembrane transporter activity
H0S59_RS10965	COG0511	ligase activity, forming carbon-carbon bonds
H0S59_RS10970	COG0439	Biotin carboxylase
H0S59_RS10980	COG2814	Major facilitator Superfamily
H0S59_RS11015	COG3293	Transposase
H0S59_RS11020	COG1063	alcohol dehydrogenase
H0S59_RS11100	COG0592	DNA-directed DNA polymerase activity
H0S59_RS11150	COG2026	Addiction module toxin, RelE StbE family
H0S59_RS11355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S59_RS11415	COG3328	transposase activity
H0S59_RS11440	COG0069	glutamate synthase activity
H0S59_RS11470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S59_RS11485	COG1335	isochorismatase
H0S59_RS11495	COG1454	alcohol dehydrogenase
H0S59_RS11500	COG0824	Thioesterase
H0S59_RS11515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0S59_RS11540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S59_RS11545	COG2030	dehydratase
H0S59_RS11555	COG0183	Belongs to the thiolase family
H0S59_RS11565	COG0583	DNA-binding transcription factor activity
H0S59_RS11570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S59_RS11580	COG1522	sequence-specific DNA binding
H0S59_RS11585	COG3135	benzoate transporter
H0S59_RS11610	COG0589	response to stress
H0S59_RS11615	COG0488	(ABC) transporter
H0S59_RS11660	COG0668	transmembrane transport
H0S59_RS11665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S59_RS11670	COG2423	ornithine cyclodeaminase activity
H0S59_RS11675	COG4264	IucA IucC family
H0S59_RS11685	COG4264	IucA IucC family
H0S59_RS11725	COG1605	Chorismate mutase
H0S59_RS11765	COG0308	aminopeptidase N
H0S59_RS11785	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H0S59_RS11795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S59_RS11800	COG1454	alcohol dehydrogenase
H0S59_RS11820	COG0531	amino acid
H0S59_RS11825	COG4303	Ethanolamine ammonia lyase large subunit
H0S59_RS11830	COG4302	ethanolamine ammonia-lyase activity
H0S59_RS11835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S59_RS11835	COG0519	Catalyzes the synthesis of GMP from XMP
H0S59_RS11860	COG0697	spore germination
H0S59_RS11865	COG1923	regulation of RNA biosynthetic process
H0S59_RS11875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S59_RS11880	COG0802	atpase or kinase
H0S59_RS11900	COG1187	pseudouridine synthase activity
H0S59_RS11915	COG0583	DNA-binding transcription factor activity
H0S59_RS11925	COG2814	Major facilitator Superfamily
H0S59_RS11930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S59_RS11960	COG0729	surface antigen
H0S59_RS11980	COG0174	glutamine synthetase
H0S59_RS11985	COG0745	RESPONSE REGULATOR receiver
H0S59_RS11990	COG2205	protein histidine kinase activity
H0S59_RS11995	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H0S59_RS12000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0S59_RS12005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0S59_RS12030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_RS12035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S59_RS12040	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS12055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S59_RS12060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S59_RS12065	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S59_RS12080	COG0583	DNA-binding transcription factor activity
H0S59_RS12095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S59_RS12105	COG3658	cytochrome
H0S59_RS12110	COG1215	transferase activity, transferring glycosyl groups
H0S59_RS12115	COG1649	PFAM Uncharacterised BCR, COG1649
H0S59_RS12115	COG0726	polysaccharide deacetylase
H0S59_RS12145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S59_RS12155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S59_RS12180	COG0305	Participates in initiation and elongation during chromosome replication
H0S59_RS12185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S59_RS12195	COG1305	Transglutaminase-like
H0S59_RS12205	COG2308	Evidence 4 Homologs of previously reported genes of
H0S59_RS12240	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S59_RS12245	COG0138	bifunctional purine biosynthesis protein purh
H0S59_RS12250	COG0151	Belongs to the GarS family
H0S59_RS12255	COG1464	Belongs to the NlpA lipoprotein family
H0S59_RS12260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S59_RS12265	COG2011	ABC-type metal ion transport system permease component
H0S59_RS12270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_RS12280	COG1301	dicarboxylic acid transport
H0S59_RS12320	COG0745	RESPONSE REGULATOR receiver
H0S59_RS12325	COG0642	Histidine kinase
H0S59_RS12330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0S59_RS12340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0S59_RS12365	COG5002	protein histidine kinase activity
H0S59_RS12380	COG2351	hydroxyisourate hydrolase activity
H0S59_RS12390	COG3008	intermembrane lipid transfer
H0S59_RS12390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S59_RS12395	COG2995	paraquat-inducible protein a
H0S59_RS12415	COG2207	Transcriptional regulator
H0S59_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS12425	COG0583	DNA-binding transcription factor activity
H0S59_RS12435	COG3328	transposase activity
H0S59_RS12440	COG1073	alpha beta
H0S59_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS12510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S59_RS12510	COG0475	glutathione-regulated potassium exporter activity
H0S59_RS12515	COG0786	glutamate:sodium symporter activity
H0S59_RS12520	COG3243	poly(R)-hydroxyalkanoic acid synthase
H0S59_RS12535	COG3111	PFAM Bacterial OB fold (BOF) protein
H0S59_RS12545	COG2226	methyltransferase
H0S59_RS12625	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H0S59_RS12660	COG3210	domain, Protein
H0S59_RS12660	COG3210	domain, Protein
H0S59_RS12665	COG2831	hemolysin activation secretion protein
H0S59_RS12690	COG2815	serine threonine protein kinase
H0S59_RS12690	COG0515	serine threonine protein kinase
H0S59_RS12720	COG1610	YqeY-like protein
H0S59_RS12750	COG1286	toxin biosynthetic process
H0S59_RS12780	COG0778	Nitroreductase
H0S59_RS12790	COG0513	Belongs to the DEAD box helicase family
H0S59_RS12810	COG2363	Small membrane protein
H0S59_RS12835	COG1234	tRNA 3'-trailer cleavage
H0S59_RS12840	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0S59_RS12845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S59_RS12855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S59_RS12875	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS12880	COG1301	dicarboxylic acid transport
H0S59_RS12885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S59_RS12890	COG3139	Protein of unknown function (DUF1315)
H0S59_RS12895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S59_RS12900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S59_RS12910	COG0494	nUDIX hydrolase
H0S59_RS12920	COG0642	Histidine kinase
H0S59_RS12930	COG3111	PFAM Bacterial OB fold (BOF) protein
H0S59_RS12935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0S59_RS12945	COG1720	tRNA m6t6A37 methyltransferase activity
H0S59_RS12955	COG0384	phenazine biosynthesis protein PhzF
H0S59_RS12960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S59_RS12965	COG0826	peptidase U32
H0S59_RS12970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S59_RS12980	COG4598	ABC transporter
H0S59_RS12985	COG4160	amino acid transport
H0S59_RS12990	COG4215	(ABC) transporter
H0S59_RS13005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS13045	COG1131	(ABC) transporter
H0S59_RS13050	COG0842	Transport permease protein
H0S59_RS13065	COG0772	Belongs to the SEDS family
H0S59_RS13070	COG2951	lytic endotransglycosylase activity
H0S59_RS13095	COG2207	Transcriptional regulator
H0S59_RS13110	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S59_RS13115	COG0024	Methionine aminopeptidase
H0S59_RS13125	COG2223	nitrite transmembrane transporter activity
H0S59_RS13135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S59_RS13140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S59_RS13145	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS13160	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S59_RS13165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0S59_RS13170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S59_RS13190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S59_RS13195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S59_RS13200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S59_RS13235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S59_RS13245	COG0174	glutamine synthetase
H0S59_RS13260	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S59_RS13285	COG2840	Smr protein MutS2
H0S59_RS13305	COG0302	gtp cyclohydrolase
H0S59_RS13325	COG3739	integral membrane protein
H0S59_RS13340	COG1741	Belongs to the pirin family
H0S59_RS13345	COG2964	Protein conserved in bacteria
H0S59_RS13390	COG2879	small protein
H0S59_RS13395	COG1966	Carbon starvation protein
H0S59_RS13400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0S59_RS13415	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H0S59_RS13440	COG1067	ATP-dependent peptidase activity
H0S59_RS13445	COG0583	DNA-binding transcription factor activity
H0S59_RS13470	COG1686	Belongs to the peptidase S11 family
H0S59_RS13475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S59_RS13500	COG3647	Membrane
H0S59_RS13515	COG0616	signal peptide processing
H0S59_RS13520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S59_RS13530	COG0573	inorganic phosphate transmembrane transporter activity
H0S59_RS13535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S59_RS13540	COG1113	amino acid transport
H0S59_RS13545	COG3961	Belongs to the TPP enzyme family
H0S59_RS13550	COG1522	sequence-specific DNA binding
H0S59_RS13560	COG0076	glutamate decarboxylase activity
H0S59_RS13565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S59_RS13590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_RS13625	COG0352	thiamine-phosphate diphosphorylase activity
H0S59_RS13650	COG0612	Peptidase, M16
H0S59_RS13660	COG1823	symporter activity
H0S59_RS13665	COG0583	DNA-binding transcription factor activity
H0S59_RS13670	COG0477	Major facilitator Superfamily
H0S59_RS13695	COG1187	pseudouridine synthase activity
H0S59_RS13710	COG1686	Belongs to the peptidase S11 family
H0S59_RS13715	COG1252	NADH dehydrogenase
H0S59_RS13725	COG0415	Belongs to the DNA photolyase family
H0S59_RS13740	COG1215	transferase activity, transferring glycosyl groups
H0S59_RS13770	COG2070	2-Nitropropane dioxygenase
H0S59_RS13825	COG0556	nucleotide-excision repair
H0S59_RS13845	COG0436	Aminotransferase
H0S59_RS13875	COG4221	oxidoreductase activity
H0S59_RS13885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S59_RS13890	COG1381	Involved in DNA repair and RecF pathway recombination
H0S59_RS13900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S59_RS13915	COG0681	Belongs to the peptidase S26 family
H0S59_RS13920	COG0481	GTPase activity
H0S59_RS13935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S59_RS13955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S59_RS13960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0S59_RS13965	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S59_RS13975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0S59_RS13980	COG4208	sulfate ABC transporter
H0S59_RS13985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S59_RS13990	COG0583	DNA-binding transcription factor activity
H0S59_RS13995	COG4625	pathogenesis
H0S59_RS14005	COG0602	queuosine metabolic process
H0S59_RS14010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S59_RS14025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S59_RS14040	COG1056	cytidyltransferase-related domain
H0S59_RS14040	COG1051	belongs to the nudix hydrolase family
H0S59_RS14045	COG1024	Enoyl-CoA hydratase
H0S59_RS14050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S59_RS14065	COG2814	Major facilitator Superfamily
H0S59_RS14070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S59_RS14070	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S59_RS14095	COG1473	amidohydrolase
H0S59_RS14100	COG0824	Thioesterase
H0S59_RS14120	COG0823	Involved in the tonB-independent uptake of proteins
H0S59_RS14140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S59_RS14175	COG0628	permease
H0S59_RS14185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S59_RS14190	COG0596	Alpha beta hydrolase
H0S59_RS14195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0S59_RS14195	COG0616	signal peptide processing
H0S59_RS14210	COG1136	(ABC) transporter
H0S59_RS14215	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0S59_RS14250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS14270	COG0463	Glycosyl transferase, family 2
H0S59_RS14280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H0S59_RS14290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_RS14310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S59_RS14315	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS14330	COG0019	diaminopimelate decarboxylase activity
H0S59_RS14340	COG1113	amino acid transport
H0S59_RS14345	COG1113	amino acid transport
H0S59_RS14360	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H0S59_RS14370	COG3339	Conserved Protein
H0S59_RS14375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0S59_RS14380	COG0243	molybdopterin cofactor binding
H0S59_RS14385	COG1929	Belongs to the glycerate kinase type-1 family
H0S59_RS14395	COG0300	oxidoreductase activity
H0S59_RS14400	COG0778	Nitroreductase
H0S59_RS14405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S59_RS14410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS14425	COG0596	Alpha beta hydrolase
H0S59_RS14430	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S59_RS14430	COG0596	Alpha beta hydrolase
H0S59_RS14435	COG1902	pentaerythritol trinitrate reductase activity
H0S59_RS14440	COG1309	transcriptional regulator
H0S59_RS14470	COG3811	Belongs to the UPF0386 family
H0S59_RS14480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S59_RS14505	COG2059	Chromate
H0S59_RS14515	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H0S59_RS14525	COG1230	cation diffusion facilitator family transporter
H0S59_RS14540	COG2814	Major facilitator Superfamily
H0S59_RS14650	COG0582	viral genome integration into host DNA
H0S59_RS14660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S59_RS14680	COG0741	lytic transglycosylase activity
H0S59_RS14700	COG0584	glycerophosphoryl diester phosphodiesterase
H0S59_RS14705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S59_RS14725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S59_RS14730	COG1597	lipid kinase activity
H0S59_RS14745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S59_RS14750	COG0477	Major facilitator Superfamily
H0S59_RS14800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S59_RS14805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S59_RS14830	COG0505	Belongs to the CarA family
H0S59_RS14845	COG1309	transcriptional regulator
H0S59_RS14850	COG0251	oxidation-reduction process
H0S59_RS14855	COG0110	maltose O-acetyltransferase activity
H0S59_RS14860	COG0589	response to stress
H0S59_RS14880	COG2843	Capsule synthesis protein
H0S59_RS14900	COG2321	neutral zinc metallopeptidase
H0S59_RS14905	COG2354	Protein conserved in bacteria
H0S59_RS14925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S59_RS14950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S59_RS14955	COG1053	succinate dehydrogenase
H0S59_RS14960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S59_RS14965	COG2009	succinate dehydrogenase
H0S59_RS15000	COG2921	Belongs to the UPF0250 family
H0S59_RS15005	COG0321	lipoyl(octanoyl) transferase activity
H0S59_RS15020	COG0531	amino acid
H0S59_RS15030	COG1733	regulation of RNA biosynthetic process
H0S59_RS15035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S59_RS15040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S59_RS15040	COG1648	precorrin-2 dehydrogenase activity
H0S59_RS15055	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S59_RS15085	COG0671	phosphoesterase, PA-phosphatase related
H0S59_RS15090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS15100	COG1538	Outer membrane efflux protein
H0S59_RS15105	COG0393	Putative heavy-metal-binding
H0S59_RS15110	COG0393	Putative heavy-metal-binding
H0S59_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
H0S59_RS15130	COG0525	valine-tRNA ligase activity
H0S59_RS15150	COG0583	DNA-binding transcription factor activity
H0S59_RS15155	COG0004	ammonium transporteR
H0S59_RS15165	COG0642	Histidine kinase
H0S59_RS15170	COG0745	RESPONSE REGULATOR receiver
H0S59_RS15175	COG2194	sulfuric ester hydrolase activity
H0S59_RS15195	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S59_RS15210	COG2315	Protein conserved in bacteria
H0S59_RS15215	COG0142	geranyltranstransferase activity
H0S59_RS15225	COG1113	amino acid transport
H0S59_RS15230	COG2816	NAD+ diphosphatase activity
H0S59_RS15235	COG3046	protein related to deoxyribodipyrimidine photolyase
H0S59_RS15265	COG2207	Transcriptional regulator
H0S59_RS15290	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_RS15310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S59_RS15320	COG1530	ribonuclease E activity
H0S59_RS15325	COG0424	maF-like protein
H0S59_RS15330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0S59_RS15335	COG1792	Involved in formation and maintenance of cell shape
H0S59_RS15340	COG1077	Cell shape determining protein MreB Mrl
H0S59_RS15345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S59_RS15355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S59_RS15380	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0S59_RS15385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S59_RS15390	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S59_RS15395	COG1115	amino acid carrier protein
H0S59_RS15415	COG2814	Major facilitator Superfamily
H0S59_RS15420	COG1289	transmembrane transporter activity
H0S59_RS15430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S59_RS15445	COG1376	ErfK ybiS ycfS ynhG family protein
H0S59_RS15450	COG2832	Protein of unknown function (DUF454)
H0S59_RS15480	COG0840	transmembrane signaling receptor activity
H0S59_RS15520	COG3422	double-strand break repair
H0S59_RS15525	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S59_RS15530	COG3189	MarR family transcriptional regulator
H0S59_RS15540	COG0354	folic acid binding
H0S59_RS15545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S59_RS15560	COG1902	pentaerythritol trinitrate reductase activity
H0S59_RS15565	COG4772	TonB-dependent receptor
H0S59_RS15570	COG2094	Belongs to the DNA glycosylase MPG family
H0S59_RS15590	COG1217	gtp-binding protein TYPA
H0S59_RS15595	COG2233	PERMEase
H0S59_RS15605	COG0833	amino acid
H0S59_RS15610	COG1690	Belongs to the RtcB family
H0S59_RS15620	COG2885	chlorophyll binding
H0S59_RS15620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H0S59_RS15630	COG0183	Belongs to the thiolase family
H0S59_RS15650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S59_RS15670	COG2207	Transcriptional regulator
H0S59_RS15675	COG0183	Belongs to the thiolase family
H0S59_RS15705	COG1272	protein, Hemolysin III
H0S59_RS15710	COG0477	Major facilitator Superfamily
H0S59_RS15725	COG0450	alkyl hydroperoxide reductase
H0S59_RS15745	COG0285	dihydrofolate synthase activity
H0S59_RS15800	COG2096	Adenosyltransferase
H0S59_RS15820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0S59_RS15825	COG0745	RESPONSE REGULATOR receiver
H0S59_RS15830	COG2205	protein histidine kinase activity
H0S59_RS15840	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS15845	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS15910	COG0438	transferase activity, transferring glycosyl groups
H0S59_RS15915	COG0463	Glycosyl transferase, family 2
H0S59_RS15920	COG0726	polysaccharide deacetylase
H0S59_RS15930	COG2194	sulfuric ester hydrolase activity
H0S59_RS15945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S59_RS15950	COG0784	Response regulator, receiver
H0S59_RS15950	COG2198	Histidine kinase
H0S59_RS15950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S59_RS15950	COG2205	protein histidine kinase activity
H0S59_RS15955	COG4695	Portal protein
H0S59_RS16150	COG0629	single-stranded DNA binding
H0S59_RS16200	COG1862	Preprotein translocase
H0S59_RS16210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0S59_RS16215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S59_RS16225	COG3781	membrane
H0S59_RS16230	COG0613	PHP domain protein
H0S59_RS16240	COG2350	Protein conserved in bacteria
H0S59_RS16275	COG1607	acyl-coa hydrolase
H0S59_RS16335	COG2199	diguanylate cyclase activity
H0S59_RS16345	COG1408	metallophosphoesterase
H0S59_RS16350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S59_RS16360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S59_RS16380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S59_RS16385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S59_RS16390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0S59_RS16395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S59_RS16400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S59_RS16410	COG2969	positive regulation of protein catabolic process
H0S59_RS16450	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS16455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S59_RS16470	COG1309	transcriptional regulator
H0S59_RS16475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S59_RS16480	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS16530	COG1183	phosphatidylcholine synthase activity
H0S59_RS16535	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S59_RS16565	COG0739	heme binding
H0S59_RS16565	COG0741	lytic transglycosylase activity
H0S59_RS16565	COG1196	nuclear chromosome segregation
H0S59_RS16575	COG1702	phosphate starvation-inducible protein PhoH
H0S59_RS16610	COG1295	ribonuclease BN
H0S59_RS16620	COG2169	Transcriptional regulator
H0S59_RS16625	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S59_RS16670	COG0557	exoribonuclease II activity
H0S59_RS16675	COG0339	signal peptide processing
H0S59_RS16680	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S59_RS16710	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S59_RS16715	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS16850	COG0088	Forms part of the polypeptide exit tunnel
H0S59_RS16855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0S59_RS16870	COG0626	cystathionine gamma-synthase activity
H0S59_RS16875	COG0433	COG0433 Predicted ATPase
H0S59_RS16880	COG1017	nitric oxide dioxygenase activity
H0S59_RS16880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S59_RS16885	COG1959	2 iron, 2 sulfur cluster binding
H0S59_RS16900	COG1301	dicarboxylic acid transport
H0S59_RS16905	COG1946	Acyl-CoA thioesterase
H0S59_RS16925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S59_RS16930	COG1040	competence protein
H0S59_RS16935	COG0494	nUDIX hydrolase
H0S59_RS16945	COG0598	Magnesium transport protein CorA
H0S59_RS16955	COG2854	intermembrane phospholipid transfer
H0S59_RS16965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S59_RS16970	COG1127	ABC transporter
H0S59_RS16995	COG0408	coproporphyrinogen oxidase activity
H0S59_RS17010	COG1960	acyl-CoA dehydrogenase activity
H0S59_RS17020	COG1983	PspC domain protein
H0S59_RS17025	COG0617	tRNA 3'-terminal CCA addition
H0S59_RS17025	COG0517	IMP dehydrogenase activity
H0S59_RS17025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0S59_RS17070	COG0583	DNA-binding transcription factor activity
H0S59_RS17110	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS17120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S59_RS17125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S59_RS17130	COG0833	amino acid
H0S59_RS17160	COG1192	Involved in chromosome partitioning
H0S59_RS17165	COG0628	permease
H0S59_RS17175	COG1289	transmembrane transporter activity
H0S59_RS17190	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_RS17195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H0S59_RS17210	COG0277	FAD linked oxidase domain protein
H0S59_RS17215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S59_RS17220	COG5006	permease, DMT superfamily
H0S59_RS17225	COG5006	permease, DMT superfamily
H0S59_RS17240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S59_RS17245	COG5380	lipid catabolic process
H0S59_RS17265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S59_RS17315	COG0194	GDP metabolic process
H0S59_RS17330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S59_RS17350	COG3307	-O-antigen
H0S59_RS17360	COG3307	-O-antigen
H0S59_RS17365	COG4969	Belongs to the N-Me-Phe pilin family
H0S59_RS17375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0S59_RS17380	COG1704	LemA family
H0S59_RS17390	COG0493	'glutamate synthase
H0S59_RS17395	COG0070	glutamate synthase
H0S59_RS17395	COG0069	glutamate synthase activity
H0S59_RS17395	COG0067	glutamate synthase
H0S59_RS17445	COG2226	methyltransferase
H0S59_RS17460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S59_RS17465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S59_RS17510	COG0833	amino acid
H0S59_RS17575	COG0488	(ABC) transporter
H0S59_RS17580	COG0028	Belongs to the TPP enzyme family
H0S59_RS17585	COG2873	o-acetylhomoserine
H0S59_RS17590	COG4221	oxidoreductase activity
H0S59_RS17595	COG0659	secondary active sulfate transmembrane transporter activity
H0S59_RS17620	COG0427	acetyl-CoA hydrolase
H0S59_RS17650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S59_RS17670	COG1132	(ABC) transporter
H0S59_RS17695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S59_RS17760	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S59_RS17765	COG1733	regulation of RNA biosynthetic process
H0S59_RS17790	COG0667	Aldo Keto reductase
H0S59_RS17810	COG0583	DNA-binding transcription factor activity
H0S59_RS17815	COG2814	Major facilitator Superfamily
H0S59_RS17850	COG1335	isochorismatase
H0S59_RS17860	COG1012	belongs to the aldehyde dehydrogenase family
H0S59_RS17865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S59_RS17875	COG1113	amino acid transport
H0S59_RS17885	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S59_RS17900	COG2814	Major facilitator Superfamily
H0S59_RS17910	COG0351	phosphomethylpyrimidine kinase
H0S59_RS17910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S59_RS17910	COG0352	thiamine-phosphate diphosphorylase activity
H0S59_RS17930	COG1309	transcriptional regulator
H0S59_RS17950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S59_RS17960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S59_RS17965	COG3162	membrane
H0S59_RS17970	COG2205	protein histidine kinase activity
H0S59_RS17970	COG2198	Histidine kinase
H0S59_RS17970	COG0784	Response regulator, receiver
H0S59_RS17995	COG1522	sequence-specific DNA binding
H0S59_RS18000	COG1335	isochorismatase
H0S59_RS18005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S59_RS18015	COG0668	transmembrane transport
H0S59_RS18020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S59_RS18025	COG1519	Transferase
H0S59_RS18030	COG1902	pentaerythritol trinitrate reductase activity
H0S59_RS18050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S59_RS18075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S59_RS18075	COG0426	domain, Protein
H0S59_RS18080	COG2119	membrane
H0S59_RS18090	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S59_RS18100	COG4942	peptidase
H0S59_RS18115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0S59_RS18125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S59_RS18145	COG0189	ligase activity
H0S59_RS18165	COG0708	Exodeoxyribonuclease III
H0S59_RS18170	COG1393	Belongs to the ArsC family
H0S59_RS18185	COG3706	GGDEF domain
H0S59_RS18220	COG2351	hydroxyisourate hydrolase activity
H0S59_RS18225	COG2233	PERMEase
H0S59_RS18235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S59_RS18245	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H0S59_RS18255	COG3150	esterase
H0S59_RS18300	COG2918	glutathione biosynthetic process
H0S59_RS18315	COG2733	membrane
H0S59_RS18320	COG0436	Aminotransferase
H0S59_RS18325	COG0534	Mate efflux family protein
H0S59_RS18415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S59_RS18420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S59_RS18430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S59_RS18445	COG1280	lysine exporter protein (LysE YggA)
H0S59_RS18450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S59_RS18465	COG0010	Belongs to the arginase family
H0S59_RS18495	COG2188	Transcriptional regulator
H0S59_RS18505	COG0523	cobalamin synthesis protein
H0S59_RS18515	COG1113	amino acid transport
H0S59_RS18525	COG0625	glutathione transferase activity
H0S59_RS18550	COG0534	Mate efflux family protein
H0S59_RS18555	COG0385	Bile acid
H0S59_RS18560	COG1335	isochorismatase
H0S59_RS18565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S59_RS18585	COG2116	formate transmembrane transporter activity
H0S59_RS18595	COG2814	Major facilitator Superfamily
H0S59_RS18630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S59_RS18645	COG2233	PERMEase
H0S59_RS18685	COG0733	neurotransmitter:sodium symporter activity
H0S59_RS18695	COG0625	glutathione transferase activity
H0S59_RS18725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S59_RS18730	COG0657	acetylesterase activity
H0S59_RS18780	COG2951	lytic endotransglycosylase activity
H0S59_RS18785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S59_RS18800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S59_RS18810	COG0671	phosphoesterase, PA-phosphatase related
H0S59_RS18815	COG0861	Integral membrane protein TerC family
H0S59_RS18830	COG0754	glutathionylspermidine amidase activity
H0S59_RS18840	COG0402	S-adenosylhomocysteine deaminase activity
H0S59_RS18855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S59_RS18860	COG1230	cation diffusion facilitator family transporter
H0S59_RS18875	COG0706	membrane insertase activity