locus-tag	class	description
AOLE_RS00010	COG0592	DNA-directed DNA polymerase activity
AOLE_RS00020	COG0187	DNA topoisomerase II activity
AOLE_RS00035	COG0488	(ABC) transporter
AOLE_RS00060	COG0596	Alpha beta hydrolase
AOLE_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOLE_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOLE_RS00105	COG0625	glutathione transferase activity
AOLE_RS00115	COG0733	neurotransmitter:sodium symporter activity
AOLE_RS00150	COG2233	PERMEase
AOLE_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_RS00200	COG2814	Major facilitator Superfamily
AOLE_RS00205	COG0656	L-ascorbic acid biosynthetic process
AOLE_RS00210	COG0583	DNA-binding transcription factor activity
AOLE_RS00225	COG1064	alcohol dehydrogenase
AOLE_RS00230	COG2818	Glycosylase
AOLE_RS00245	COG1194	a g-specific adenine glycosylase
AOLE_RS00265	COG2983	Belongs to the UPF0260 family
AOLE_RS00270	COG2133	pyrroloquinoline quinone binding
AOLE_RS00275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOLE_RS00280	COG2116	formate transmembrane transporter activity
AOLE_RS00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_RS00305	COG1335	isochorismatase
AOLE_RS00310	COG0385	Bile acid
AOLE_RS00315	COG0534	Mate efflux family protein
AOLE_RS00320	COG1683	Conserved Protein
AOLE_RS00335	COG0346	lactoylglutathione lyase activity
AOLE_RS00340	COG0625	glutathione transferase activity
AOLE_RS00350	COG1113	amino acid transport
AOLE_RS00360	COG0523	cobalamin synthesis protein
AOLE_RS00370	COG2188	Transcriptional regulator
AOLE_RS00400	COG0010	Belongs to the arginase family
AOLE_RS00410	COG0546	phosphoglycolate phosphatase activity
AOLE_RS00415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOLE_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOLE_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AOLE_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AOLE_RS00550	COG0534	Mate efflux family protein
AOLE_RS00555	COG0436	Aminotransferase
AOLE_RS00560	COG2733	membrane
AOLE_RS00575	COG2918	glutathione biosynthetic process
AOLE_RS00610	COG3150	esterase
AOLE_RS00620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AOLE_RS00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_RS00640	COG2233	PERMEase
AOLE_RS00645	COG2351	hydroxyisourate hydrolase activity
AOLE_RS00680	COG3706	GGDEF domain
AOLE_RS00695	COG1393	Belongs to the ArsC family
AOLE_RS00700	COG0708	Exodeoxyribonuclease III
AOLE_RS00720	COG0189	ligase activity
AOLE_RS00740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOLE_RS00750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOLE_RS00765	COG4942	peptidase
AOLE_RS00775	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_RS00785	COG2119	membrane
AOLE_RS00790	COG4774	siderophore transport
AOLE_RS00795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_RS00795	COG0426	domain, Protein
AOLE_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AOLE_RS00835	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS00840	COG1519	Transferase
AOLE_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOLE_RS00850	COG0668	transmembrane transport
AOLE_RS00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOLE_RS00865	COG1335	isochorismatase
AOLE_RS00870	COG1522	sequence-specific DNA binding
AOLE_RS00895	COG2205	protein histidine kinase activity
AOLE_RS00895	COG2198	Histidine kinase
AOLE_RS00895	COG0784	Response regulator, receiver
AOLE_RS00900	COG3162	membrane
AOLE_RS00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOLE_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOLE_RS00935	COG1309	transcriptional regulator
AOLE_RS00955	COG4221	oxidoreductase activity
AOLE_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOLE_RS00965	COG0352	thiamine-phosphate diphosphorylase activity
AOLE_RS00965	COG0351	phosphomethylpyrimidine kinase
AOLE_RS00975	COG2814	Major facilitator Superfamily
AOLE_RS00980	COG0629	single-stranded DNA binding
AOLE_RS00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOLE_RS01000	COG1113	amino acid transport
AOLE_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOLE_RS01015	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS01025	COG1335	isochorismatase
AOLE_RS01065	COG2814	Major facilitator Superfamily
AOLE_RS01070	COG0583	DNA-binding transcription factor activity
AOLE_RS01095	COG1309	transcriptional regulator
AOLE_RS01135	COG0667	Aldo Keto reductase
AOLE_RS01170	COG1733	regulation of RNA biosynthetic process
AOLE_RS01175	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOLE_RS01185	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AOLE_RS01190	COG2207	Transcriptional regulator
AOLE_RS01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOLE_RS01260	COG2329	Antibiotic biosynthesis monooxygenase
AOLE_RS01265	COG0697	spore germination
AOLE_RS01275	COG4619	ABC transporter
AOLE_RS01295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOLE_RS01325	COG0427	acetyl-CoA hydrolase
AOLE_RS01345	COG0659	secondary active sulfate transmembrane transporter activity
AOLE_RS01350	COG4221	oxidoreductase activity
AOLE_RS01360	COG2814	Major facilitator Superfamily
AOLE_RS01375	COG0488	(ABC) transporter
AOLE_RS01440	COG0833	amino acid
AOLE_RS01495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOLE_RS01500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOLE_RS01515	COG2226	methyltransferase
AOLE_RS01565	COG0067	glutamate synthase
AOLE_RS01565	COG0070	glutamate synthase
AOLE_RS01565	COG0069	glutamate synthase activity
AOLE_RS01570	COG0493	'glutamate synthase
AOLE_RS01580	COG1704	LemA family
AOLE_RS01585	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AOLE_RS01595	COG4969	Belongs to the N-Me-Phe pilin family
AOLE_RS01605	COG3307	-O-antigen
AOLE_RS01625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOLE_RS01635	COG0194	GDP metabolic process
AOLE_RS01685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOLE_RS01695	COG0335	large ribosomal subunit rRNA binding
AOLE_RS01705	COG5380	lipid catabolic process
AOLE_RS01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOLE_RS01725	COG5006	permease, DMT superfamily
AOLE_RS01735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOLE_RS01740	COG0277	FAD linked oxidase domain protein
AOLE_RS01760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AOLE_RS01765	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOLE_RS01785	COG1289	transmembrane transporter activity
AOLE_RS01795	COG0628	permease
AOLE_RS01800	COG1192	Involved in chromosome partitioning
AOLE_RS01830	COG0833	amino acid
AOLE_RS01835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOLE_RS01840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOLE_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS01890	COG0583	DNA-binding transcription factor activity
AOLE_RS01920	COG0752	glycyl-tRNA synthetase alpha subunit
AOLE_RS01950	COG0517	IMP dehydrogenase activity
AOLE_RS01950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AOLE_RS01950	COG0617	tRNA 3'-terminal CCA addition
AOLE_RS01955	COG1983	PspC domain protein
AOLE_RS01965	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS01980	COG0408	coproporphyrinogen oxidase activity
AOLE_RS02000	COG0513	Belongs to the DEAD box helicase family
AOLE_RS02005	COG1127	ABC transporter
AOLE_RS02010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOLE_RS02020	COG2854	intermembrane phospholipid transfer
AOLE_RS02030	COG0598	Magnesium transport protein CorA
AOLE_RS02040	COG0494	nUDIX hydrolase
AOLE_RS02045	COG1040	competence protein
AOLE_RS02050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOLE_RS02070	COG1946	Acyl-CoA thioesterase
AOLE_RS02075	COG1301	dicarboxylic acid transport
AOLE_RS02090	COG1959	2 iron, 2 sulfur cluster binding
AOLE_RS02095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_RS02095	COG1017	nitric oxide dioxygenase activity
AOLE_RS02100	COG0433	COG0433 Predicted ATPase
AOLE_RS02105	COG0626	cystathionine gamma-synthase activity
AOLE_RS02120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOLE_RS02125	COG0088	Forms part of the polypeptide exit tunnel
AOLE_RS02145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOLE_RS02260	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS02265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AOLE_RS02295	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AOLE_RS02300	COG0339	signal peptide processing
AOLE_RS02305	COG0557	exoribonuclease II activity
AOLE_RS02350	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOLE_RS02355	COG1295	ribonuclease BN
AOLE_RS02390	COG1702	phosphate starvation-inducible protein PhoH
AOLE_RS02400	COG1196	nuclear chromosome segregation
AOLE_RS02400	COG0739	heme binding
AOLE_RS02400	COG0741	lytic transglycosylase activity
AOLE_RS02430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOLE_RS02435	COG1183	phosphatidylcholine synthase activity
AOLE_RS02480	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS02485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOLE_RS02490	COG1309	transcriptional regulator
AOLE_RS02505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOLE_RS02510	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS02550	COG2969	positive regulation of protein catabolic process
AOLE_RS02560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOLE_RS02565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOLE_RS02575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOLE_RS02580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOLE_RS02600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOLE_RS02610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOLE_RS02615	COG1408	metallophosphoesterase
AOLE_RS02620	COG2885	chlorophyll binding
AOLE_RS02625	COG2199	diguanylate cyclase activity
AOLE_RS02660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_RS02685	COG1607	acyl-coa hydrolase
AOLE_RS02720	COG2350	Protein conserved in bacteria
AOLE_RS02730	COG0613	PHP domain protein
AOLE_RS02735	COG3781	membrane
AOLE_RS02745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOLE_RS02760	COG1862	Preprotein translocase
AOLE_RS02795	COG2205	protein histidine kinase activity
AOLE_RS02795	COG3437	response regulator, receiver
AOLE_RS02795	COG3850	Histidine kinase
AOLE_RS02795	COG4999	Histidine kinase
AOLE_RS02800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOLE_RS02820	COG0726	polysaccharide deacetylase
AOLE_RS02825	COG0463	Glycosyl transferase, family 2
AOLE_RS02830	COG0438	transferase activity, transferring glycosyl groups
AOLE_RS02860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOLE_RS02895	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS02900	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS02910	COG2205	protein histidine kinase activity
AOLE_RS02915	COG0745	RESPONSE REGULATOR receiver
AOLE_RS02925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOLE_RS02945	COG2096	Adenosyltransferase
AOLE_RS02950	COG4206	TonB-dependent receptor
AOLE_RS02995	COG0285	dihydrofolate synthase activity
AOLE_RS03015	COG0450	alkyl hydroperoxide reductase
AOLE_RS03030	COG0477	Major facilitator Superfamily
AOLE_RS03035	COG1272	protein, Hemolysin III
AOLE_RS03045	COG2153	protein acetylation
AOLE_RS03065	COG0183	Belongs to the thiolase family
AOLE_RS03070	COG2207	Transcriptional regulator
AOLE_RS03090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_RS03105	COG0183	Belongs to the thiolase family
AOLE_RS03115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AOLE_RS03115	COG2885	chlorophyll binding
AOLE_RS03120	COG1690	Belongs to the RtcB family
AOLE_RS03125	COG0833	amino acid
AOLE_RS03135	COG2233	PERMEase
AOLE_RS03140	COG1217	gtp-binding protein TYPA
AOLE_RS03155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOLE_RS03165	COG2094	Belongs to the DNA glycosylase MPG family
AOLE_RS03170	COG4772	TonB-dependent receptor
AOLE_RS03175	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS03180	COG0679	Auxin Efflux Carrier
AOLE_RS03190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOLE_RS03195	COG0354	folic acid binding
AOLE_RS03205	COG3189	MarR family transcriptional regulator
AOLE_RS03210	COG2824	Alkylphosphonate utilization operon protein PhnA
AOLE_RS03215	COG3422	double-strand break repair
AOLE_RS03255	COG0840	transmembrane signaling receptor activity
AOLE_RS03285	COG2832	Protein of unknown function (DUF454)
AOLE_RS03290	COG1376	ErfK ybiS ycfS ynhG family protein
AOLE_RS03330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOLE_RS03340	COG1289	transmembrane transporter activity
AOLE_RS03345	COG2814	Major facilitator Superfamily
AOLE_RS03360	COG1115	amino acid carrier protein
AOLE_RS03365	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOLE_RS03370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOLE_RS03375	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AOLE_RS03405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOLE_RS03415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOLE_RS03420	COG1077	Cell shape determining protein MreB Mrl
AOLE_RS03425	COG1792	Involved in formation and maintenance of cell shape
AOLE_RS03430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AOLE_RS03435	COG0424	maF-like protein
AOLE_RS03440	COG1530	ribonuclease E activity
AOLE_RS03445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_RS03490	COG2207	Transcriptional regulator
AOLE_RS03515	COG1113	amino acid transport
AOLE_RS03525	COG0142	geranyltranstransferase activity
AOLE_RS03530	COG2315	Protein conserved in bacteria
AOLE_RS03545	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOLE_RS03570	COG2194	sulfuric ester hydrolase activity
AOLE_RS03575	COG0745	RESPONSE REGULATOR receiver
AOLE_RS03580	COG0642	Histidine kinase
AOLE_RS03590	COG0004	ammonium transporteR
AOLE_RS03595	COG0583	DNA-binding transcription factor activity
AOLE_RS03620	COG0525	valine-tRNA ligase activity
AOLE_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS03640	COG0393	Putative heavy-metal-binding
AOLE_RS03645	COG0393	Putative heavy-metal-binding
AOLE_RS03650	COG1538	Outer membrane efflux protein
AOLE_RS03660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_RS03665	COG0671	phosphoesterase, PA-phosphatase related
AOLE_RS03690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOLE_RS03705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOLE_RS03705	COG1648	precorrin-2 dehydrogenase activity
AOLE_RS03710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOLE_RS03745	COG0531	amino acid
AOLE_RS03760	COG0321	lipoyl(octanoyl) transferase activity
AOLE_RS03765	COG2921	Belongs to the UPF0250 family
AOLE_RS03805	COG2009	succinate dehydrogenase
AOLE_RS03810	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOLE_RS03815	COG1053	succinate dehydrogenase
AOLE_RS03820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOLE_RS03840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_RS03860	COG2354	Protein conserved in bacteria
AOLE_RS03865	COG2321	neutral zinc metallopeptidase
AOLE_RS03895	COG2843	Capsule synthesis protein
AOLE_RS03910	COG0589	response to stress
AOLE_RS03930	COG0505	Belongs to the CarA family
AOLE_RS03955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOLE_RS03960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOLE_RS04010	COG0477	Major facilitator Superfamily
AOLE_RS04015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOLE_RS04030	COG1597	lipid kinase activity
AOLE_RS04035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOLE_RS04060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_RS04065	COG0584	glycerophosphoryl diester phosphodiesterase
AOLE_RS04085	COG0741	lytic transglycosylase activity
AOLE_RS04105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOLE_RS04125	COG0583	DNA-binding transcription factor activity
AOLE_RS04130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_RS04165	COG1309	transcriptional regulator
AOLE_RS04170	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS04175	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_RS04175	COG0596	Alpha beta hydrolase
AOLE_RS04180	COG0596	Alpha beta hydrolase
AOLE_RS04180	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_RS04185	COG0596	Alpha beta hydrolase
AOLE_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_RS04205	COG0778	Nitroreductase
AOLE_RS04220	COG1929	Belongs to the glycerate kinase type-1 family
AOLE_RS04230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AOLE_RS04260	COG1113	amino acid transport
AOLE_RS04270	COG0019	diaminopimelate decarboxylase activity
AOLE_RS04280	COG2267	carboxylic ester hydrolase activity
AOLE_RS04285	COG1280	lysine exporter protein (LysE YggA)
AOLE_RS04290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOLE_RS04315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_RS04335	COG0463	Glycosyl transferase, family 2
AOLE_RS04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_RS04380	COG0697	spore germination
AOLE_RS04385	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOLE_RS04390	COG1136	(ABC) transporter
AOLE_RS04395	COG0658	competence protein
AOLE_RS04395	COG2333	competence protein COMEC
AOLE_RS04405	COG0616	signal peptide processing
AOLE_RS04405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOLE_RS04415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOLE_RS04425	COG0628	permease
AOLE_RS04460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOLE_RS04480	COG0823	Involved in the tonB-independent uptake of proteins
AOLE_RS04500	COG0824	Thioesterase
AOLE_RS04505	COG1473	amidohydrolase
AOLE_RS04525	COG0047	phosphoribosylformylglycinamidine synthase activity
AOLE_RS04525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOLE_RS04535	COG2814	Major facilitator Superfamily
AOLE_RS04540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOLE_RS04545	COG1024	Enoyl-CoA hydratase
AOLE_RS04550	COG1056	cytidyltransferase-related domain
AOLE_RS04550	COG1051	belongs to the nudix hydrolase family
AOLE_RS04570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOLE_RS04585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOLE_RS04590	COG0602	queuosine metabolic process
AOLE_RS04600	COG4625	pathogenesis
AOLE_RS04605	COG0583	DNA-binding transcription factor activity
AOLE_RS04610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOLE_RS04615	COG4208	sulfate ABC transporter
AOLE_RS04620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AOLE_RS04630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOLE_RS04635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOLE_RS04640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOLE_RS04660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOLE_RS04670	COG0481	GTPase activity
AOLE_RS04675	COG0681	Belongs to the peptidase S26 family
AOLE_RS04685	COG0571	ribonuclease III activity
AOLE_RS04690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOLE_RS04705	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AOLE_RS04715	COG4221	oxidoreductase activity
AOLE_RS04740	COG0436	Aminotransferase
AOLE_RS04760	COG0556	nucleotide-excision repair
AOLE_RS04815	COG2070	2-Nitropropane dioxygenase
AOLE_RS04840	COG1215	transferase activity, transferring glycosyl groups
AOLE_RS04855	COG0415	Belongs to the DNA photolyase family
AOLE_RS04865	COG1252	NADH dehydrogenase
AOLE_RS04870	COG1686	Belongs to the peptidase S11 family
AOLE_RS04885	COG1187	pseudouridine synthase activity
AOLE_RS04895	COG0477	Major facilitator Superfamily
AOLE_RS04900	COG0583	DNA-binding transcription factor activity
AOLE_RS04905	COG1823	symporter activity
AOLE_RS04915	COG0612	Peptidase, M16
AOLE_RS04940	COG0352	thiamine-phosphate diphosphorylase activity
AOLE_RS04975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_RS05000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOLE_RS05005	COG0076	glutamate decarboxylase activity
AOLE_RS05015	COG1522	sequence-specific DNA binding
AOLE_RS05020	COG3961	Belongs to the TPP enzyme family
AOLE_RS05025	COG1113	amino acid transport
AOLE_RS05030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOLE_RS05035	COG0573	inorganic phosphate transmembrane transporter activity
AOLE_RS05045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOLE_RS05050	COG0616	signal peptide processing
AOLE_RS05090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOLE_RS05095	COG1686	Belongs to the peptidase S11 family
AOLE_RS05120	COG0583	DNA-binding transcription factor activity
AOLE_RS05125	COG1067	ATP-dependent peptidase activity
AOLE_RS05130	COG2211	Major facilitator Superfamily
AOLE_RS05165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOLE_RS05170	COG1966	Carbon starvation protein
AOLE_RS05175	COG2879	small protein
AOLE_RS05245	COG1309	transcriptional regulator
AOLE_RS05280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOLE_RS05285	COG2423	ornithine cyclodeaminase activity
AOLE_RS05300	COG1741	Belongs to the pirin family
AOLE_RS05315	COG3739	integral membrane protein
AOLE_RS05335	COG0302	gtp cyclohydrolase
AOLE_RS05345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AOLE_RS05370	COG0512	Glutamine amidotransferase of anthranilate synthase
AOLE_RS05385	COG0174	glutamine synthetase
AOLE_RS05395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOLE_RS05430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOLE_RS05435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOLE_RS05440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOLE_RS05450	COG0281	malic enzyme
AOLE_RS05450	COG0280	phosphate acetyltransferase
AOLE_RS05460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOLE_RS05465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOLE_RS05470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOLE_RS05490	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS05495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOLE_RS05500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_RS05515	COG2223	nitrite transmembrane transporter activity
AOLE_RS05525	COG0024	Methionine aminopeptidase
AOLE_RS05530	COG0052	Belongs to the universal ribosomal protein uS2 family
AOLE_RS05545	COG2207	Transcriptional regulator
AOLE_RS05575	COG2951	lytic endotransglycosylase activity
AOLE_RS05580	COG0772	Belongs to the SEDS family
AOLE_RS05595	COG0842	Transport permease protein
AOLE_RS05600	COG1131	(ABC) transporter
AOLE_RS05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_RS05655	COG4215	(ABC) transporter
AOLE_RS05660	COG4160	amino acid transport
AOLE_RS05665	COG4598	ABC transporter
AOLE_RS05675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOLE_RS05680	COG0826	peptidase U32
AOLE_RS05685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_RS05690	COG0384	phenazine biosynthesis protein PhzF
AOLE_RS05700	COG1720	tRNA m6t6A37 methyltransferase activity
AOLE_RS05710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOLE_RS05725	COG0642	Histidine kinase
AOLE_RS05735	COG0494	nUDIX hydrolase
AOLE_RS05745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOLE_RS05750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOLE_RS05755	COG3139	Protein of unknown function (DUF1315)
AOLE_RS05765	COG1301	dicarboxylic acid transport
AOLE_RS05770	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS05780	COG2819	hydrolase of the alpha beta superfamily
AOLE_RS05790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOLE_RS05800	COG2195	Cleaves the N-terminal amino acid of tripeptides
AOLE_RS05820	COG1690	Belongs to the RtcB family
AOLE_RS05825	COG1234	tRNA 3'-trailer cleavage
AOLE_RS05830	COG4650	regulator
AOLE_RS05860	COG2363	Small membrane protein
AOLE_RS05880	COG0513	Belongs to the DEAD box helicase family
AOLE_RS05890	COG0778	Nitroreductase
AOLE_RS05920	COG1286	toxin biosynthetic process
AOLE_RS05945	COG4783	chaperone-mediated protein folding
AOLE_RS05950	COG1610	YqeY-like protein
AOLE_RS05980	COG0515	serine threonine protein kinase
AOLE_RS05980	COG2815	serine threonine protein kinase
AOLE_RS06005	COG1278	Cold shock
AOLE_RS06030	COG0534	Mate efflux family protein
AOLE_RS06050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_RS06055	COG4221	oxidoreductase activity
AOLE_RS06060	COG1733	regulation of RNA biosynthetic process
AOLE_RS06065	COG2085	NADP oxidoreductase coenzyme F420-dependent
AOLE_RS06095	COG3243	poly(R)-hydroxyalkanoic acid synthase
AOLE_RS06100	COG0786	glutamate:sodium symporter activity
AOLE_RS06105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOLE_RS06105	COG0475	glutathione-regulated potassium exporter activity
AOLE_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS06135	COG2985	domain, Protein
AOLE_RS06145	COG2995	paraquat-inducible protein a
AOLE_RS06150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOLE_RS06150	COG3008	intermembrane lipid transfer
AOLE_RS06160	COG2351	hydroxyisourate hydrolase activity
AOLE_RS06175	COG5002	protein histidine kinase activity
AOLE_RS06200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOLE_RS06210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOLE_RS06215	COG0642	Histidine kinase
AOLE_RS06220	COG0745	RESPONSE REGULATOR receiver
AOLE_RS06235	COG1794	racemase activity, acting on amino acids and derivatives
AOLE_RS06245	COG2175	clavaminate synthase activity
AOLE_RS06250	COG3246	L-lysine catabolic process to acetate
AOLE_RS06255	COG2814	Major facilitator Superfamily
AOLE_RS06270	COG2855	membrane
AOLE_RS06305	COG2814	Major facilitator Superfamily
AOLE_RS06320	COG0625	glutathione transferase activity
AOLE_RS06335	COG1301	dicarboxylic acid transport
AOLE_RS06350	COG2011	ABC-type metal ion transport system permease component
AOLE_RS06355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOLE_RS06360	COG1464	Belongs to the NlpA lipoprotein family
AOLE_RS06365	COG0151	Belongs to the GarS family
AOLE_RS06375	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOLE_RS06415	COG1305	Transglutaminase-like
AOLE_RS06425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOLE_RS06430	COG0305	Participates in initiation and elongation during chromosome replication
AOLE_RS06455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AOLE_RS06465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOLE_RS06470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOLE_RS06495	COG1649	PFAM Uncharacterised BCR, COG1649
AOLE_RS06495	COG0726	polysaccharide deacetylase
AOLE_RS06500	COG1215	transferase activity, transferring glycosyl groups
AOLE_RS06505	COG3658	cytochrome
AOLE_RS06515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_RS06535	COG2890	protein-(glutamine-N5) methyltransferase activity
AOLE_RS06540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_RS06545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_RS06560	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS06565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_RS06580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOLE_RS06590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AOLE_RS06595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AOLE_RS06605	COG2205	protein histidine kinase activity
AOLE_RS06610	COG0745	RESPONSE REGULATOR receiver
AOLE_RS06615	COG0174	glutamine synthetase
AOLE_RS06630	COG0477	Major facilitator Superfamily
AOLE_RS06635	COG0729	surface antigen
AOLE_RS06665	COG0471	metal ion transport
AOLE_RS06675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOLE_RS06680	COG2814	Major facilitator Superfamily
AOLE_RS06695	COG0583	DNA-binding transcription factor activity
AOLE_RS06710	COG1187	pseudouridine synthase activity
AOLE_RS06730	COG0802	atpase or kinase
AOLE_RS06735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOLE_RS06745	COG1923	regulation of RNA biosynthetic process
AOLE_RS06750	COG0697	spore germination
AOLE_RS06775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOLE_RS06780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOLE_RS06780	COG0519	Catalyzes the synthesis of GMP from XMP
AOLE_RS06785	COG4302	ethanolamine ammonia-lyase activity
AOLE_RS06790	COG4303	Ethanolamine ammonia lyase large subunit
AOLE_RS06795	COG0531	amino acid
AOLE_RS06815	COG1454	alcohol dehydrogenase
AOLE_RS06820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOLE_RS06830	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AOLE_RS06850	COG0308	aminopeptidase N
AOLE_RS06890	COG1605	Chorismate mutase
AOLE_RS06895	COG1309	transcriptional regulator
AOLE_RS06945	COG1733	regulation of RNA biosynthetic process
AOLE_RS06970	COG0583	DNA-binding transcription factor activity
AOLE_RS06980	COG3111	PFAM Bacterial OB fold (BOF) protein
AOLE_RS07000	COG0488	(ABC) transporter
AOLE_RS07005	COG0589	response to stress
AOLE_RS07025	COG3135	benzoate transporter
AOLE_RS07030	COG1522	sequence-specific DNA binding
AOLE_RS07040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOLE_RS07045	COG0583	DNA-binding transcription factor activity
AOLE_RS07055	COG0183	Belongs to the thiolase family
AOLE_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS07065	COG2030	dehydratase
AOLE_RS07070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOLE_RS07095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOLE_RS07105	COG0824	Thioesterase
AOLE_RS07110	COG1454	alcohol dehydrogenase
AOLE_RS07135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOLE_RS07165	COG0069	glutamate synthase activity
AOLE_RS07195	COG2814	Major facilitator Superfamily
AOLE_RS07210	COG0511	ligase activity, forming carbon-carbon bonds
AOLE_RS07235	COG4264	IucA IucC family
AOLE_RS07245	COG4264	IucA IucC family
AOLE_RS07250	COG2423	ornithine cyclodeaminase activity
AOLE_RS07255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOLE_RS07260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_RS07260	COG1116	anion transmembrane transporter activity
AOLE_RS07265	COG0745	RESPONSE REGULATOR receiver
AOLE_RS07275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_RS07275	COG2146	nitrite reductase [NAD(P)H] activity
AOLE_RS07280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_RS07285	COG0243	molybdopterin cofactor binding
AOLE_RS07295	COG0243	molybdopterin cofactor binding
AOLE_RS07300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOLE_RS07315	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOLE_RS07315	COG0315	cyclic pyranopterin monophosphate synthase activity
AOLE_RS07320	COG0303	'Molybdopterin
AOLE_RS07330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_RS07335	COG0697	spore germination
AOLE_RS07360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOLE_RS07380	COG1335	isochorismatase
AOLE_RS07420	COG2204	response regulator
AOLE_RS07445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOLE_RS07450	COG0575	Belongs to the CDS family
AOLE_RS07465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOLE_RS07485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOLE_RS07495	COG2137	regulation of response to DNA damage stimulus
AOLE_RS07505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AOLE_RS07510	COG1011	Hydrolase
AOLE_RS07555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOLE_RS07635	COG1484	DNA-dependent DNA replication
AOLE_RS07730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_RS07750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOLE_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS07760	COG3118	belongs to the thioredoxin family
AOLE_RS07765	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS07775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AOLE_RS07785	COG2814	Major facilitator Superfamily
AOLE_RS07790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AOLE_RS07800	COG1294	oxidase, subunit
AOLE_RS07805	COG1271	oxidase subunit
AOLE_RS07820	COG4771	TonB-dependent receptor
AOLE_RS08010	COG0592	DNA-directed DNA polymerase activity
AOLE_RS08085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOLE_RS08115	COG1522	sequence-specific DNA binding
AOLE_RS08125	COG1113	amino acid transport
AOLE_RS08145	COG0659	secondary active sulfate transmembrane transporter activity
AOLE_RS08165	COG3300	MHYT domain
AOLE_RS08165	COG5001	Diguanylate cyclase
AOLE_RS08185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AOLE_RS08185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOLE_RS08185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOLE_RS08190	COG1105	Belongs to the carbohydrate kinase PfkB family
AOLE_RS08195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOLE_RS08195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOLE_RS08225	COG0024	Methionine aminopeptidase
AOLE_RS08230	COG0583	DNA-binding transcription factor activity
AOLE_RS08245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOLE_RS08250	COG0517	IMP dehydrogenase activity
AOLE_RS08250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AOLE_RS08275	COG0552	protein localization to endoplasmic reticulum
AOLE_RS08305	COG1294	oxidase, subunit
AOLE_RS08320	COG1585	Membrane protein implicated in regulation of membrane protease activity
AOLE_RS08330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOLE_RS08350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOLE_RS08355	COG0569	domain protein
AOLE_RS08360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOLE_RS08390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOLE_RS08395	COG0542	response to heat
AOLE_RS08405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOLE_RS08420	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOLE_RS08420	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS08460	COG0148	phosphopyruvate hydratase activity
AOLE_RS08465	COG2323	membrane
AOLE_RS08480	COG4773	Receptor
AOLE_RS08490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AOLE_RS08500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOLE_RS08505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOLE_RS08510	COG0183	Belongs to the thiolase family
AOLE_RS08515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AOLE_RS08520	COG0596	Alpha beta hydrolase
AOLE_RS08525	COG2271	Major facilitator Superfamily
AOLE_RS08530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOLE_RS08535	COG3485	protocatechuate 3,4-dioxygenase
AOLE_RS08540	COG3485	protocatechuate 3,4-dioxygenase
AOLE_RS08545	COG0710	3-dehydroquinate dehydratase activity
AOLE_RS08550	COG3420	alginic acid biosynthetic process
AOLE_RS08555	COG3659	wide pore channel activity
AOLE_RS08560	COG4993	Dehydrogenase
AOLE_RS08570	COG2391	methyltransferase activity
AOLE_RS08585	COG1414	Transcriptional regulator
AOLE_RS08590	COG0583	DNA-binding transcription factor activity
AOLE_RS08595	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS08620	COG2814	Major facilitator Superfamily
AOLE_RS08630	COG0154	amidase activity
AOLE_RS08650	COG4638	Rieske (2fe-2S)
AOLE_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS08670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_RS08680	COG3733	amine oxidase
AOLE_RS08695	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS08705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOLE_RS08710	COG0183	Belongs to the thiolase family
AOLE_RS08715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOLE_RS08720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOLE_RS08730	COG4829	muconolactone delta-isomerase
AOLE_RS08735	COG4948	Mandelate Racemase Muconate Lactonizing
AOLE_RS08740	COG0583	DNA-binding transcription factor activity
AOLE_RS08750	COG0583	DNA-binding transcription factor activity
AOLE_RS08755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_RS08760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_RS08785	COG1079	Belongs to the binding-protein-dependent transport system permease family
AOLE_RS08805	COG3829	transcription factor binding
AOLE_RS08815	COG3829	transcription factor binding
AOLE_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS08825	COG1414	Transcriptional regulator
AOLE_RS08830	COG1053	succinate dehydrogenase
AOLE_RS08845	COG3659	wide pore channel activity
AOLE_RS08850	COG1309	transcriptional regulator
AOLE_RS08870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOLE_RS08880	COG1053	succinate dehydrogenase
AOLE_RS08885	COG1053	succinate dehydrogenase
AOLE_RS08915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AOLE_RS08950	COG1309	transcriptional regulator
AOLE_RS08965	COG4689	acetoacetate decarboxylase
AOLE_RS08975	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS08985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_RS08985	COG3321	synthase
AOLE_RS08985	COG4221	oxidoreductase activity
AOLE_RS08985	COG0604	alcohol dehydrogenase
AOLE_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS09010	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_RS09035	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS09045	COG1733	regulation of RNA biosynthetic process
AOLE_RS09050	COG0702	epimerase
AOLE_RS09060	COG1309	transcriptional regulator
AOLE_RS09095	COG3047	cAMP biosynthetic process
AOLE_RS09095	COG2885	chlorophyll binding
AOLE_RS09105	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AOLE_RS09125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOLE_RS09145	COG2831	hemolysin activation secretion protein
AOLE_RS09150	COG3210	domain, Protein
AOLE_RS09190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_RS09205	COG2271	Major facilitator Superfamily
AOLE_RS09215	COG1566	PFAM secretion protein HlyD family protein
AOLE_RS09230	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS09235	COG0129	dihydroxy-acid dehydratase activity
AOLE_RS09245	COG0583	DNA-binding transcription factor activity
AOLE_RS09250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOLE_RS09260	COG2084	Dehydrogenase
AOLE_RS09265	COG2207	Transcriptional regulator
AOLE_RS09270	COG1064	alcohol dehydrogenase
AOLE_RS09280	COG1309	transcriptional regulator
AOLE_RS09295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOLE_RS09300	COG1120	ATPase activity
AOLE_RS09320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOLE_RS09390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOLE_RS09460	COG1414	Transcriptional regulator
AOLE_RS09465	COG2851	Citrate transporter
AOLE_RS09470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOLE_RS09475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_RS09505	COG2259	Doxx family
AOLE_RS09510	COG0583	DNA-binding transcription factor activity
AOLE_RS09515	COG2205	protein histidine kinase activity
AOLE_RS09520	COG0745	RESPONSE REGULATOR receiver
AOLE_RS09525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_RS09530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_RS09535	COG1538	Outer membrane efflux protein
AOLE_RS09555	COG2072	flavoprotein involved in K transport
AOLE_RS09565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOLE_RS09585	COG4628	conserved protein (DUF2132)
AOLE_RS09595	COG2175	clavaminate synthase activity
AOLE_RS09600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOLE_RS09615	COG0667	Aldo Keto reductase
AOLE_RS09620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_RS09635	COG2175	clavaminate synthase activity
AOLE_RS09665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_RS09670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_RS09705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_RS09710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_RS09720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_RS09735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOLE_RS09740	COG0805	protein transport
AOLE_RS09750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_RS09765	COG1132	(ABC) transporter
AOLE_RS09770	COG1132	(ABC) transporter
AOLE_RS09790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOLE_RS09795	COG0601	transmembrane transport
AOLE_RS09825	COG3539	Fimbrial protein
AOLE_RS09850	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOLE_RS09860	COG0753	catalase activity
AOLE_RS09880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOLE_RS09930	COG4771	TonB-dependent receptor
AOLE_RS09935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_RS09940	COG3433	isochorismatase activity
AOLE_RS09940	COG1535	isochorismatase
AOLE_RS09945	COG1021	2,3-dihydroxybenzoate-AMP ligase
AOLE_RS09950	COG1169	isochorismate synthase
AOLE_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS09965	COG3251	PFAM MbtH domain protein
AOLE_RS09970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_RS10000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AOLE_RS10005	COG4149	molybdate abc transporter
AOLE_RS10010	COG0725	ABC transporter, periplasmic molybdate-binding protein
AOLE_RS10020	COG4638	Rieske (2fe-2S)
AOLE_RS10025	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AOLE_RS10030	COG0543	2 iron, 2 sulfur cluster binding
AOLE_RS10030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_RS10045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS10075	COG2207	Transcriptional regulator
AOLE_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS10085	COG2610	gluconate transmembrane transporter activity
AOLE_RS10090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_RS10120	COG2814	Major facilitator Superfamily
AOLE_RS10140	COG0583	DNA-binding transcription factor activity
AOLE_RS10155	COG2031	fatty acid transporter
AOLE_RS10160	COG0183	Belongs to the thiolase family
AOLE_RS10165	COG0583	DNA-binding transcription factor activity
AOLE_RS10170	COG0583	DNA-binding transcription factor activity
AOLE_RS10185	COG1027	Aspartate ammonia-lyase
AOLE_RS10195	COG0477	Major facilitator Superfamily
AOLE_RS10215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_RS10220	COG4521	taurine ABC transporter
AOLE_RS10235	COG2188	Transcriptional regulator
AOLE_RS10240	COG2207	Transcriptional regulator
AOLE_RS10240	COG3708	Transcriptional regulator
AOLE_RS10255	COG0730	response to heat
AOLE_RS10265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_RS10265	COG3453	Protein conserved in bacteria
AOLE_RS10275	COG3781	membrane
AOLE_RS10280	COG1063	alcohol dehydrogenase
AOLE_RS10290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOLE_RS10295	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOLE_RS10300	COG0022	dehydrogenase e1 component
AOLE_RS10305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOLE_RS10310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOLE_RS10325	COG3706	GGDEF domain
AOLE_RS10345	COG0133	tryptophan synthase activity
AOLE_RS10355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOLE_RS10385	COG0583	DNA-binding transcription factor activity
AOLE_RS10390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AOLE_RS10400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOLE_RS10440	COG0537	adenosine 5'-monophosphoramidase activity
AOLE_RS10465	COG0842	Transport permease protein
AOLE_RS10470	COG0842	Transport permease protein
AOLE_RS10475	COG1131	(ABC) transporter
AOLE_RS10490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOLE_RS10495	COG4773	Receptor
AOLE_RS10515	COG0730	response to heat
AOLE_RS10520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOLE_RS10535	COG0406	alpha-ribazole phosphatase activity
AOLE_RS10540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AOLE_RS10555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOLE_RS10565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOLE_RS10580	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS10585	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS10590	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_RS10595	COG2207	Transcriptional regulator
AOLE_RS10600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOLE_RS10605	COG0776	regulation of translation
AOLE_RS10630	COG0822	iron-sulfur transferase activity
AOLE_RS10635	COG0316	Belongs to the HesB IscA family
AOLE_RS10665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOLE_RS10685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOLE_RS10690	COG0702	epimerase
AOLE_RS10730	COG0601	transmembrane transport
AOLE_RS10735	COG0339	signal peptide processing
AOLE_RS10740	COG4166	transmembrane transport
AOLE_RS10755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AOLE_RS10780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOLE_RS10785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOLE_RS10800	COG2431	L-lysine efflux transmembrane transporter activity
AOLE_RS10815	COG0776	regulation of translation
AOLE_RS10880	COG0084	hydrolase, TatD family'
AOLE_RS10900	COG1663	tetraacyldisaccharide 4'-kinase activity
AOLE_RS10905	COG1132	(ABC) transporter
AOLE_RS10915	COG0811	peptide transport
AOLE_RS10920	COG1475	DNA binding
AOLE_RS10925	COG1192	Involved in chromosome partitioning
AOLE_RS10935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOLE_RS10950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOLE_RS10955	COG0191	fructose-bisphosphate aldolase activity
AOLE_RS10975	COG0424	maF-like protein
AOLE_RS10980	COG2850	peptidyl-arginine hydroxylation
AOLE_RS10990	COG0640	Transcriptional regulator
AOLE_RS11000	COG3619	membrane
AOLE_RS11005	COG3122	Protein conserved in bacteria
AOLE_RS11010	COG1132	(ABC) transporter
AOLE_RS11030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AOLE_RS11035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOLE_RS11045	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOLE_RS11045	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOLE_RS11045	COG0506	proline dehydrogenase activity
AOLE_RS11050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AOLE_RS11065	COG3698	Phosphodiester glycosidase
AOLE_RS11075	COG2353	YceI-like domain
AOLE_RS11085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOLE_RS11130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOLE_RS11130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOLE_RS11155	COG3539	Fimbrial protein
AOLE_RS11190	COG0583	DNA-binding transcription factor activity
AOLE_RS11195	COG0697	spore germination
AOLE_RS11205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AOLE_RS11215	COG0583	DNA-binding transcription factor activity
AOLE_RS11230	COG1309	transcriptional regulator
AOLE_RS11245	COG1522	sequence-specific DNA binding
AOLE_RS11255	COG1126	abc transporter atp-binding protein
AOLE_RS11260	COG0765	amino acid transport
AOLE_RS11265	COG0765	amino acid transport
AOLE_RS11295	COG1464	Belongs to the NlpA lipoprotein family
AOLE_RS11305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOLE_RS11310	COG2011	ABC-type metal ion transport system permease component
AOLE_RS11315	COG0012	GTP binding
AOLE_RS11340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOLE_RS11375	COG2207	Transcriptional regulator
AOLE_RS11375	COG1917	Cupin 2, conserved barrel domain protein
AOLE_RS11380	COG0386	Belongs to the glutathione peroxidase family
AOLE_RS11390	COG0436	Aminotransferase
AOLE_RS11395	COG1301	dicarboxylic acid transport
AOLE_RS11430	COG3634	alkyl hydroperoxide reductase activity
AOLE_RS11445	COG0583	DNA-binding transcription factor activity
AOLE_RS11450	COG0798	PFAM Bile acid sodium symporter
AOLE_RS11455	COG0640	Transcriptional regulator
AOLE_RS11465	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AOLE_RS11475	COG0583	DNA-binding transcription factor activity
AOLE_RS11485	COG1953	Uracil, thiamine, allantoin
AOLE_RS11495	COG2175	clavaminate synthase activity
AOLE_RS11500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_RS11505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AOLE_RS11510	COG4521	taurine ABC transporter
AOLE_RS11520	COG0477	Major facilitator Superfamily
AOLE_RS11540	COG1271	oxidase subunit
AOLE_RS11545	COG1294	oxidase, subunit
AOLE_RS11550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_RS11570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AOLE_RS11590	COG3052	prosthetic group binding
AOLE_RS11595	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AOLE_RS11605	COG2814	Major facilitator Superfamily
AOLE_RS11620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_RS11625	COG1346	cytolysis
AOLE_RS11635	COG0583	DNA-binding transcription factor activity
AOLE_RS11640	COG0625	glutathione transferase activity
AOLE_RS11645	COG0625	glutathione transferase activity
AOLE_RS11665	COG0583	DNA-binding transcription factor activity
AOLE_RS11680	COG1045	serine acetyltransferase
AOLE_RS11685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOLE_RS11690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOLE_RS11695	COG1280	lysine exporter protein (LysE YggA)
AOLE_RS11705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOLE_RS11710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOLE_RS11720	COG0765	amino acid transport
AOLE_RS11725	COG0765	amino acid transport
AOLE_RS11760	COG0784	Response regulator, receiver
AOLE_RS11760	COG2205	protein histidine kinase activity
AOLE_RS11780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOLE_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS11840	COG0583	DNA-binding transcription factor activity
AOLE_RS11850	COG2814	Major facilitator Superfamily
AOLE_RS11865	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_RS11870	COG1309	transcriptional regulator
AOLE_RS11875	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS11880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOLE_RS11885	COG1024	Enoyl-CoA hydratase
AOLE_RS11890	COG4770	biotin carboxylase activity
AOLE_RS11900	COG0583	DNA-binding transcription factor activity
AOLE_RS11915	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS11925	COG2814	Major facilitator Superfamily
AOLE_RS11935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOLE_RS11940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOLE_RS11945	COG2814	Major facilitator Superfamily
AOLE_RS11950	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS11955	COG1024	Enoyl-CoA hydratase
AOLE_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS11965	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOLE_RS11970	COG0183	Belongs to the thiolase family
AOLE_RS11980	COG2814	Major facilitator Superfamily
AOLE_RS11990	COG1024	Enoyl-CoA hydratase
AOLE_RS12000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_RS12005	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS12010	COG2814	Major facilitator Superfamily
AOLE_RS12015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOLE_RS12020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AOLE_RS12035	COG3842	ATPase activity
AOLE_RS12040	COG1840	ABC-type Fe3 transport system, periplasmic component
AOLE_RS12050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_RS12055	COG1414	Transcriptional regulator
AOLE_RS12065	COG0583	DNA-binding transcription factor activity
AOLE_RS12075	COG1469	GTP cyclohydrolase I activity
AOLE_RS12080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOLE_RS12080	COG4451	ribulose bisphosphate carboxylase, small
AOLE_RS12085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AOLE_RS12090	COG1760	l-serine dehydratase
AOLE_RS12095	COG0531	amino acid
AOLE_RS12100	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS12125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOLE_RS12145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_RS12160	COG0789	Transcriptional regulator
AOLE_RS12170	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AOLE_RS12175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_RS12190	COG2807	transmembrane transport
AOLE_RS12195	COG0590	tRNA wobble adenosine to inosine editing
AOLE_RS12200	COG0666	response to abiotic stimulus
AOLE_RS12245	COG2885	chlorophyll binding
AOLE_RS12345	COG3209	COG3209 Rhs family protein
AOLE_RS12370	COG0477	Major facilitator Superfamily
AOLE_RS12385	COG1116	anion transmembrane transporter activity
AOLE_RS12390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOLE_RS12400	COG0864	Transcriptional regulator
AOLE_RS12405	COG1733	regulation of RNA biosynthetic process
AOLE_RS12410	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOLE_RS12415	COG0439	Biotin carboxylase
AOLE_RS12430	COG1063	alcohol dehydrogenase
AOLE_RS12435	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOLE_RS12495	COG0038	chloride channel
AOLE_RS12500	COG4770	biotin carboxylase activity
AOLE_RS12520	COG1914	H( )-stimulated, divalent metal cation uptake system
AOLE_RS12535	COG1595	DNA-templated transcription, initiation
AOLE_RS12545	COG3220	belongs to the UPF0276 family
AOLE_RS12560	COG0300	oxidoreductase activity
AOLE_RS12605	COG1309	transcriptional regulator
AOLE_RS12615	COG1073	alpha beta
AOLE_RS12620	COG1073	alpha beta
AOLE_RS12630	COG1051	belongs to the nudix hydrolase family
AOLE_RS12635	COG1309	transcriptional regulator
AOLE_RS12650	COG0657	acetylesterase activity
AOLE_RS12665	COG1595	DNA-templated transcription, initiation
AOLE_RS12670	COG3712	iron ion homeostasis
AOLE_RS12690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOLE_RS12695	COG4774	siderophore transport
AOLE_RS12715	COG4521	taurine ABC transporter
AOLE_RS12720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_RS12725	COG1116	anion transmembrane transporter activity
AOLE_RS12730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AOLE_RS12740	COG2271	Major facilitator Superfamily
AOLE_RS12745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOLE_RS12750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_RS12755	COG0583	DNA-binding transcription factor activity
AOLE_RS12760	COG3038	cytochrome b561
AOLE_RS12765	COG0753	catalase activity
AOLE_RS12785	COG1278	Cold shock
AOLE_RS12815	COG1522	sequence-specific DNA binding
AOLE_RS12820	COG0531	amino acid
AOLE_RS12825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOLE_RS12840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOLE_RS12880	COG2050	protein possibly involved in aromatic compounds catabolism
AOLE_RS12890	COG3327	negative regulation of DNA-templated transcription, initiation
AOLE_RS12895	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AOLE_RS12900	COG0183	Belongs to the thiolase family
AOLE_RS12905	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOLE_RS12910	COG1024	Enoyl-CoA hydratase
AOLE_RS12915	COG1024	Enoyl-CoA hydratase
AOLE_RS12920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_RS12925	COG2151	metal-sulfur cluster biosynthetic enzyme
AOLE_RS12930	COG3396	Phenylacetate-CoA oxygenase
AOLE_RS12935	COG3460	Phenylacetate-CoA oxygenase
AOLE_RS12940	COG3396	Phenylacetate-CoA oxygenase
AOLE_RS12945	COG2030	dehydratase
AOLE_RS12945	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS12970	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOLE_RS12980	COG4122	O-methyltransferase activity
AOLE_RS13015	COG1137	ATPase activity
AOLE_RS13020	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AOLE_RS13030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOLE_RS13090	COG2814	Major facilitator Superfamily
AOLE_RS13125	COG0668	transmembrane transport
AOLE_RS13185	COG2226	methyltransferase
AOLE_RS13205	COG1278	Cold shock
AOLE_RS13210	COG1560	Kdo2-lipid A biosynthetic process
AOLE_RS13215	COG1280	lysine exporter protein (LysE YggA)
AOLE_RS13250	COG1570	exodeoxyribonuclease VII activity
AOLE_RS13280	COG3791	Glutathione-dependent formaldehyde-activating
AOLE_RS13330	COG2871	sodium ion transport
AOLE_RS13340	COG0583	DNA-binding transcription factor activity
AOLE_RS13345	COG4638	Rieske (2fe-2S)
AOLE_RS13350	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AOLE_RS13355	COG0633	Ferredoxin
AOLE_RS13355	COG0543	2 iron, 2 sulfur cluster binding
AOLE_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS13365	COG3135	benzoate transporter
AOLE_RS13370	COG2814	Major facilitator Superfamily
AOLE_RS13385	COG1643	Atp-dependent helicase
AOLE_RS13400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOLE_RS13420	COG3634	alkyl hydroperoxide reductase activity
AOLE_RS13440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOLE_RS13465	COG0625	glutathione transferase activity
AOLE_RS13475	COG2885	chlorophyll binding
AOLE_RS13510	COG0542	response to heat
AOLE_RS13525	COG1765	OsmC-like protein
AOLE_RS13535	COG0667	Aldo Keto reductase
AOLE_RS13550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOLE_RS13565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOLE_RS13575	COG0527	aspartate kinase activity
AOLE_RS13585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOLE_RS13595	COG3038	cytochrome b561
AOLE_RS13600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AOLE_RS13605	COG2252	PERMEase
AOLE_RS13615	COG1741	Belongs to the pirin family
AOLE_RS13620	COG1309	transcriptional regulator
AOLE_RS13635	COG2072	flavoprotein involved in K transport
AOLE_RS13640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AOLE_RS13645	COG0583	DNA-binding transcription factor activity
AOLE_RS13660	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AOLE_RS13690	COG1944	ATP diphosphatase activity
AOLE_RS13710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOLE_RS13725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_RS13740	COG2814	Major facilitator Superfamily
AOLE_RS13745	COG1024	Enoyl-CoA hydratase
AOLE_RS13750	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS13760	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS13785	COG2186	Transcriptional regulator
AOLE_RS13790	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS13800	COG4948	Mandelate Racemase Muconate Lactonizing
AOLE_RS13805	COG2271	Major facilitator Superfamily
AOLE_RS13810	COG2721	sulfolactate sulfo-lyase activity
AOLE_RS13815	COG0697	spore germination
AOLE_RS13865	COG3210	domain, Protein
AOLE_RS13870	COG2831	hemolysin activation secretion protein
AOLE_RS13875	COG1113	amino acid transport
AOLE_RS13895	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS13915	COG0531	amino acid
AOLE_RS13925	COG1113	amino acid transport
AOLE_RS13965	COG1309	transcriptional regulator
AOLE_RS13975	COG4269	membrane
AOLE_RS14000	COG1902	pentaerythritol trinitrate reductase activity
AOLE_RS14000	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOLE_RS14010	COG5001	Diguanylate cyclase
AOLE_RS14010	COG3706	GGDEF domain
AOLE_RS14010	COG4251	negative regulation of phosphorylation
AOLE_RS14010	COG2203	Gaf domain
AOLE_RS14020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOLE_RS14040	COG4172	Belongs to the ABC transporter superfamily
AOLE_RS14045	COG4239	(ABC) transporter, permease
AOLE_RS14050	COG4174	ABC transporter (Permease)
AOLE_RS14055	COG4166	transmembrane transport
AOLE_RS14060	COG0741	lytic transglycosylase activity
AOLE_RS14060	COG0741	lytic transglycosylase activity
AOLE_RS14060	COG1388	LysM domain
AOLE_RS14060	COG1388	LysM domain
AOLE_RS14105	COG0583	DNA-binding transcription factor activity
AOLE_RS14110	COG1279	arginine transmembrane transporter activity
AOLE_RS14120	COG0789	Transcriptional regulator
AOLE_RS14130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_RS14135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOLE_RS14140	COG0006	proline dipeptidase activity
AOLE_RS14170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOLE_RS14185	COG3384	dioxygenase
AOLE_RS14195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOLE_RS14200	COG2878	Part of a membrane complex involved in electron transport
AOLE_RS14205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOLE_RS14225	COG0768	penicillin binding
AOLE_RS14230	COG0742	ribosomal rna small subunit methyltransferase
AOLE_RS14245	COG0830	nickel cation binding
AOLE_RS14255	COG0804	urea catabolic process
AOLE_RS14280	COG3015	lipoprotein NlpE involved in copper resistance
AOLE_RS14295	COG1253	flavin adenine dinucleotide binding
AOLE_RS14300	COG2851	Citrate transporter
AOLE_RS14345	COG1773	rubredoxin
AOLE_RS14350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOLE_RS14360	COG0583	DNA-binding transcription factor activity
AOLE_RS14385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AOLE_RS14390	COG4181	ATPase activity
AOLE_RS14435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOLE_RS14455	COG0306	phosphate transporter
AOLE_RS14470	COG3958	Transketolase
AOLE_RS14475	COG3959	Transketolase, thiamine diphosphate binding domain
AOLE_RS14480	COG2271	Major facilitator Superfamily
AOLE_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS14490	COG0583	DNA-binding transcription factor activity
AOLE_RS14505	COG2223	nitrite transmembrane transporter activity
AOLE_RS14515	COG2066	Belongs to the glutaminase family
AOLE_RS14520	COG0242	peptide deformylase activity
AOLE_RS14525	COG0477	Major facilitator Superfamily
AOLE_RS14535	COG0028	Belongs to the TPP enzyme family
AOLE_RS14550	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS14555	COG2267	carboxylic ester hydrolase activity
AOLE_RS14565	COG2271	Major facilitator Superfamily
AOLE_RS14580	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS14600	COG1414	Transcriptional regulator
AOLE_RS14620	COG1024	Enoyl-CoA hydratase
AOLE_RS14630	COG1309	transcriptional regulator
AOLE_RS14640	COG1215	transferase activity, transferring glycosyl groups
AOLE_RS14645	COG0726	polysaccharide deacetylase
AOLE_RS14645	COG1649	PFAM Uncharacterised BCR, COG1649
AOLE_RS14655	COG4681	YaeQ
AOLE_RS14665	COG0523	cobalamin synthesis protein
AOLE_RS14675	COG1607	acyl-coa hydrolase
AOLE_RS14685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOLE_RS14690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOLE_RS14695	COG1309	transcriptional regulator
AOLE_RS14720	COG2040	homocysteine
AOLE_RS14725	COG0531	amino acid
AOLE_RS14780	COG1595	DNA-templated transcription, initiation
AOLE_RS14790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_RS14795	COG0477	Major facilitator Superfamily
AOLE_RS14980	COG3566	protein conserved in bacteria
AOLE_RS15000	COG3567	Phage-associated protein, HI1409 family
AOLE_RS15005	COG5410	chromosome segregation
AOLE_RS15080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOLE_RS15130	COG0405	Gamma-glutamyltransferase
AOLE_RS15135	COG2814	Major facilitator Superfamily
AOLE_RS15140	COG1566	PFAM secretion protein HlyD family protein
AOLE_RS15145	COG2050	protein possibly involved in aromatic compounds catabolism
AOLE_RS15160	COG1090	epimerase
AOLE_RS15180	COG0420	3'-5' exonuclease activity
AOLE_RS15190	COG1968	undecaprenyl-diphosphatase activity
AOLE_RS15210	COG0735	belongs to the Fur family
AOLE_RS15215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOLE_RS15220	COG2914	Belongs to the UPF0125 (RnfH) family
AOLE_RS15235	COG0121	glutamine amidotransferase
AOLE_RS15250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOLE_RS15260	COG0210	DNA helicase
AOLE_RS15265	COG2885	chlorophyll binding
AOLE_RS15270	COG0204	Acyl-transferase
AOLE_RS15300	COG1280	lysine exporter protein (LysE YggA)
AOLE_RS15305	COG1674	ftsk spoiiie
AOLE_RS15310	COG0492	ferredoxin-NADP+ reductase activity
AOLE_RS15315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AOLE_RS15325	COG0456	acetyltransferase
AOLE_RS15345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOLE_RS15350	COG0049	tRNA binding
AOLE_RS15355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOLE_RS15370	COG1981	membrane
AOLE_RS15380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOLE_RS15380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOLE_RS15400	COG1012	belongs to the aldehyde dehydrogenase family
AOLE_RS15405	COG4638	Rieske (2fe-2S)
AOLE_RS15410	COG0657	acetylesterase activity
AOLE_RS15420	COG0473	3-isopropylmalate dehydrogenase activity
AOLE_RS15425	COG0583	DNA-binding transcription factor activity
AOLE_RS15440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOLE_RS15475	COG0358	DNA primase activity
AOLE_RS15490	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AOLE_RS15510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOLE_RS15540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOLE_RS15550	COG0351	phosphomethylpyrimidine kinase
AOLE_RS15550	COG0352	thiamine-phosphate diphosphorylase activity
AOLE_RS15550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOLE_RS15555	COG1652	LysM domain
AOLE_RS15580	COG1399	metal-binding, possibly nucleic acid-binding protein
AOLE_RS15585	COG3101	peptidyl-lysine hydroxylation
AOLE_RS15590	COG0009	L-threonylcarbamoyladenylate synthase
AOLE_RS15595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOLE_RS15600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOLE_RS15615	COG4106	trans-aconitate 2-methyltransferase activity
AOLE_RS15630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOLE_RS15630	COG2226	methyltransferase
AOLE_RS15630	COG0596	Alpha beta hydrolase
AOLE_RS15640	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AOLE_RS15645	COG2223	nitrite transmembrane transporter activity
AOLE_RS15665	COG1196	nuclear chromosome segregation
AOLE_RS15675	COG0730	response to heat
AOLE_RS15690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOLE_RS15700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOLE_RS15750	COG0489	protein tyrosine kinase activity
AOLE_RS15765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOLE_RS15765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOLE_RS15800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AOLE_RS15805	COG2081	HI0933 family
AOLE_RS15810	COG0668	transmembrane transport
AOLE_RS15830	COG0583	DNA-binding transcription factor activity
AOLE_RS15850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOLE_RS15855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOLE_RS15885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOLE_RS15910	COG2199	diguanylate cyclase activity
AOLE_RS15925	COG0745	RESPONSE REGULATOR receiver
AOLE_RS15940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOLE_RS15975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOLE_RS15980	COG0583	DNA-binding transcription factor activity
AOLE_RS15985	COG0384	phenazine biosynthesis protein PhzF
AOLE_RS16040	COG1309	transcriptional regulator
AOLE_RS16045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOLE_RS16060	COG0583	DNA-binding transcription factor activity
AOLE_RS16090	COG0583	DNA-binding transcription factor activity
AOLE_RS16105	COG0583	DNA-binding transcription factor activity
AOLE_RS16110	COG1053	succinate dehydrogenase
AOLE_RS16125	COG1309	transcriptional regulator
AOLE_RS16135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOLE_RS16140	COG2814	Major facilitator Superfamily
AOLE_RS16145	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS16150	COG0583	DNA-binding transcription factor activity
AOLE_RS16155	COG1063	alcohol dehydrogenase
AOLE_RS16185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOLE_RS16190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AOLE_RS16195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOLE_RS16215	COG2132	Multicopper oxidase
AOLE_RS16225	COG0561	phosphatase activity
AOLE_RS16230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOLE_RS16255	COG1214	PFAM Peptidase M22, glycoprotease
AOLE_RS16315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOLE_RS16320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOLE_RS16325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOLE_RS16385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOLE_RS16395	COG1846	Transcriptional regulator
AOLE_RS16400	COG1764	response to oxidative stress
AOLE_RS16440	COG0037	tRNA processing
AOLE_RS16450	COG0248	Ppx GppA phosphatase
AOLE_RS16475	COG0072	phenylalanine-tRNA ligase activity
AOLE_RS16505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOLE_RS16515	COG1238	metal cluster binding
AOLE_RS16520	COG0625	glutathione transferase activity
AOLE_RS16525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AOLE_RS16535	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_RS16540	COG3028	Belongs to the UPF0307 family
AOLE_RS16545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOLE_RS16565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOLE_RS16570	COG0617	tRNA 3'-terminal CCA addition
AOLE_RS16575	COG1555	photosystem II stabilization
AOLE_RS16580	COG3956	TIGRFAM MazG family protein
AOLE_RS16585	COG4221	oxidoreductase activity
AOLE_RS16590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOLE_RS16605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOLE_RS16610	COG5002	protein histidine kinase activity
AOLE_RS16610	COG2205	protein histidine kinase activity
AOLE_RS16610	COG0784	Response regulator, receiver
AOLE_RS16615	COG1024	Enoyl-CoA hydratase
AOLE_RS16620	COG2084	Dehydrogenase
AOLE_RS16625	COG3622	Belongs to the hyi family
AOLE_RS16655	COG0697	spore germination
AOLE_RS16665	COG2814	Major facilitator Superfamily
AOLE_RS16670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOLE_RS16685	COG0583	DNA-binding transcription factor activity
AOLE_RS16690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOLE_RS16700	COG0084	hydrolase, TatD family'
AOLE_RS16715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOLE_RS16740	COG0440	acetolactate synthase activity
AOLE_RS16745	COG0028	Belongs to the TPP enzyme family
AOLE_RS16770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOLE_RS16775	COG1136	(ABC) transporter
AOLE_RS16775	COG0577	efflux transmembrane transporter activity
AOLE_RS16795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOLE_RS16800	COG1162	GTPase activity
AOLE_RS16810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AOLE_RS16830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOLE_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS16875	COG2986	histidine ammonia-lyase
AOLE_RS16885	COG1216	Glycosyl transferase, family 2
AOLE_RS16890	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_RS16900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOLE_RS16925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOLE_RS16945	COG1426	Protein conserved in bacteria
AOLE_RS16965	COG2975	iron-sulfur cluster assembly
AOLE_RS16980	COG0793	Belongs to the peptidase S41A family
AOLE_RS16995	COG2267	carboxylic ester hydrolase activity
AOLE_RS17005	COG3265	gluconokinase activity
AOLE_RS17015	COG0800	Aldolase
AOLE_RS17025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOLE_RS17030	COG0857	belongs to the CobB CobQ family
AOLE_RS17030	COG0280	phosphate acetyltransferase
AOLE_RS17035	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AOLE_RS17035	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AOLE_RS17055	COG0740	serine-type endopeptidase activity
AOLE_RS17065	COG4774	siderophore transport
AOLE_RS17075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOLE_RS17085	COG2813	Specifically methylates the guanine in position
AOLE_RS17085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOLE_RS17185	COG0788	formyltetrahydrofolate deformylase activity
AOLE_RS17210	COG4651	solute:proton antiporter activity
AOLE_RS17210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOLE_RS17230	COG0724	RNA recognition motif
AOLE_RS17235	COG0210	DNA helicase
AOLE_RS17260	COG1733	regulation of RNA biosynthetic process
AOLE_RS17265	COG0604	alcohol dehydrogenase
AOLE_RS17270	COG2900	Belongs to the SlyX family
AOLE_RS17275	COG0488	(ABC) transporter
AOLE_RS17285	COG1560	Kdo2-lipid A biosynthetic process
AOLE_RS17295	COG1301	dicarboxylic acid transport
AOLE_RS17350	COG0473	3-isopropylmalate dehydrogenase activity
AOLE_RS17375	COG0583	DNA-binding transcription factor activity
AOLE_RS17415	COG0583	DNA-binding transcription factor activity
AOLE_RS17425	COG0625	glutathione transferase activity
AOLE_RS17430	COG2378	regulation of single-species biofilm formation
AOLE_RS17445	COG1530	ribonuclease E activity
AOLE_RS17450	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_RS17465	COG0583	DNA-binding transcription factor activity
AOLE_RS17470	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS17475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOLE_RS17485	COG0534	Mate efflux family protein
AOLE_RS17500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOLE_RS17525	COG0493	'glutamate synthase
AOLE_RS17535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AOLE_RS17540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOLE_RS17555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOLE_RS17565	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AOLE_RS17565	COG0644	oxidoreductase
AOLE_RS17580	COG4535	Mg2 and Co2 transporter CorC
AOLE_RS17590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOLE_RS17615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOLE_RS17625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOLE_RS17635	COG0484	heat shock protein binding
AOLE_RS17640	COG0789	Transcriptional regulator
AOLE_RS17645	COG0598	Magnesium transport protein CorA
AOLE_RS17650	COG1185	polyribonucleotide nucleotidyltransferase activity
AOLE_RS17660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOLE_RS17665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOLE_RS17670	COG1074	ATP-dependent DNA helicase activity
AOLE_RS17675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOLE_RS17695	COG2226	methyltransferase
AOLE_RS17705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOLE_RS17725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOLE_RS17740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOLE_RS17740	COG2111	Na H antiporter
AOLE_RS17745	COG1006	Multisubunit Na H antiporter MnhC subunit
AOLE_RS17750	COG0651	ATP synthesis coupled electron transport
AOLE_RS17755	COG1863	multisubunit Na H antiporter MnhE subunit
AOLE_RS17760	COG2212	antiporter activity
AOLE_RS17765	COG1320	monovalent cation:proton antiporter activity
AOLE_RS17770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOLE_RS17780	COG0195	Participates in both transcription termination and antitermination
AOLE_RS17830	COG0237	dephospho-CoA kinase activity
AOLE_RS17840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOLE_RS17855	COG0497	DNA recombination
AOLE_RS17865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOLE_RS17895	COG2169	Transcriptional regulator
AOLE_RS17895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOLE_RS17900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AOLE_RS17965	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AOLE_RS17980	COG0326	Molecular chaperone. Has ATPase activity
AOLE_RS17995	COG2056	Na+-H+ antiporter family
AOLE_RS18035	COG0222	ribosome binding
AOLE_RS18040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOLE_RS18100	COG0546	phosphoglycolate phosphatase activity
AOLE_RS18105	COG1716	ATPase activity
AOLE_RS18150	COG0181	hydroxymethylbilane synthase activity
AOLE_RS18160	COG3275	phosphorelay sensor kinase activity
AOLE_RS18180	COG1538	Outer membrane efflux protein
AOLE_RS18185	COG0697	spore germination
AOLE_RS18205	COG0494	nUDIX hydrolase
AOLE_RS18215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOLE_RS18220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOLE_RS18225	COG0772	Belongs to the SEDS family
AOLE_RS18250	COG4974	Belongs to the 'phage' integrase family
AOLE_RS18255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOLE_RS18265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOLE_RS18275	COG2197	response regulator
AOLE_RS18290	COG0793	Belongs to the peptidase S41A family
AOLE_RS18295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AOLE_RS18300	COG0795	lipopolysaccharide-transporting ATPase activity
AOLE_RS18340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOLE_RS18340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOLE_RS18350	COG0004	ammonium transporteR
AOLE_RS18355	COG0347	Belongs to the P(II) protein family
AOLE_RS18365	COG0606	chelatase, subunit chli
AOLE_RS18370	COG0431	NADPH-dependent FMN reductase
AOLE_RS18375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOLE_RS18380	COG0235	Class ii aldolase
AOLE_RS18385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOLE_RS18400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOLE_RS18415	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_RS18425	COG0477	Major facilitator Superfamily
AOLE_RS18430	COG2860	membrane
AOLE_RS18440	COG1253	flavin adenine dinucleotide binding
AOLE_RS18450	COG2814	Major facilitator Superfamily
AOLE_RS18460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOLE_RS18495	COG0655	NAD(P)H dehydrogenase (quinone) activity
AOLE_RS18510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOLE_RS18545	COG1309	transcriptional regulator
AOLE_RS18580	COG0758	DNA mediated transformation
AOLE_RS18590	COG0697	spore germination
AOLE_RS18595	COG1309	transcriptional regulator
AOLE_RS18610	COG0386	Belongs to the glutathione peroxidase family
AOLE_RS18620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOLE_RS18625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOLE_RS18675	COG1121	(ABC) transporter
AOLE_RS18680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOLE_RS18685	COG1280	lysine exporter protein (LysE YggA)
AOLE_RS18690	COG2837	iron assimilation
AOLE_RS18695	COG0281	malic enzyme
AOLE_RS18745	COG0519	Catalyzes the synthesis of GMP from XMP
AOLE_RS18745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOLE_RS18750	COG4399	Belongs to the UPF0754 family
AOLE_RS18755	COG2259	Doxx family
AOLE_RS18760	COG0586	Pfam SNARE associated Golgi protein
AOLE_RS18775	COG1192	Involved in chromosome partitioning
AOLE_RS18785	COG0271	Belongs to the BolA IbaG family
AOLE_RS18820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOLE_RS18830	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS18835	COG0318	PFAM AMP-dependent synthetase and ligase
AOLE_RS18840	COG2197	response regulator
AOLE_RS18850	COG3916	Acyl-homoserine-lactone synthase
AOLE_RS18855	COG0477	Major facilitator Superfamily
AOLE_RS18860	COG1024	Enoyl-CoA hydratase
AOLE_RS18865	COG1024	Enoyl-CoA hydratase
AOLE_RS18870	COG1960	acyl-CoA dehydrogenase activity
AOLE_RS18875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOLE_RS18895	COG1113	amino acid transport
AOLE_RS18900	COG1113	amino acid transport
AOLE_RS18905	COG0251	oxidation-reduction process
AOLE_RS18945	COG0564	pseudouridine synthase activity
AOLE_RS19050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOLE_RS19065	COG1802	Transcriptional regulator
AOLE_RS19070	COG1448	Aminotransferase
AOLE_RS19075	COG0277	FAD linked oxidase domain protein
AOLE_RS19085	COG2186	Transcriptional regulator
AOLE_RS19095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOLE_RS19105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AOLE_RS19105	COG2755	lipolytic protein G-D-S-L family
AOLE_RS19110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOLE_RS19125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AOLE_RS19130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOLE_RS19135	COG1216	Glycosyl transferase, family 2
AOLE_RS19150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AOLE_RS19165	COG0438	transferase activity, transferring glycosyl groups
AOLE_RS19190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOLE_RS19220	COG0728	peptidoglycan biosynthetic process
AOLE_RS19225	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOLE_RS19255	COG1017	nitric oxide dioxygenase activity
AOLE_RS19255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOLE_RS19280	COG0546	phosphoglycolate phosphatase activity
AOLE_RS19285	COG1028	Short-chain dehydrogenase reductase Sdr
AOLE_RS19300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOLE_RS19300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AOLE_RS19305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_RS19310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOLE_RS19315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOLE_RS19320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOLE_RS19325	COG1116	anion transmembrane transporter activity
AOLE_RS19330	COG1309	transcriptional regulator
AOLE_RS19335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOLE_RS19345	COG0196	riboflavin kinase activity
AOLE_RS19350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOLE_RS19360	COG1047	Peptidyl-prolyl cis-trans
AOLE_RS19400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AOLE_RS19405	COG0657	acetylesterase activity
AOLE_RS19425	COG0583	DNA-binding transcription factor activity
AOLE_RS19455	COG2951	lytic endotransglycosylase activity
AOLE_RS19460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AOLE_RS19475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOLE_RS19485	COG0671	phosphoesterase, PA-phosphatase related
AOLE_RS19490	COG0861	Integral membrane protein TerC family
AOLE_RS19500	COG0402	S-adenosylhomocysteine deaminase activity
AOLE_RS19515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOLE_RS19520	COG1230	cation diffusion facilitator family transporter
AOLE_RS19535	COG0706	membrane insertase activity
AOLE_RS19585	COG1674	ftsk spoiiie