locus-tag	class	description
G0028_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G0028_RS00010	COG0592	DNA-directed DNA polymerase activity
G0028_RS00020	COG0187	DNA topoisomerase II activity
G0028_RS00030	COG0488	(ABC) transporter
G0028_RS00040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G0028_RS00045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G0028_RS00050	COG0596	Alpha beta hydrolase
G0028_RS00110	COG1012	belongs to the aldehyde dehydrogenase family
G0028_RS00115	COG3738	Protein conserved in bacteria
G0028_RS00120	COG0733	neurotransmitter:sodium symporter activity
G0028_RS00210	COG2814	Major facilitator Superfamily
G0028_RS00230	COG0583	DNA-binding transcription factor activity
G0028_RS00245	COG1064	alcohol dehydrogenase
G0028_RS00250	COG2818	Glycosylase
G0028_RS00260	COG0739	heme binding
G0028_RS00265	COG1194	a g-specific adenine glycosylase
G0028_RS00280	COG5487	UPF0391 membrane protein
G0028_RS00285	COG2983	Belongs to the UPF0260 family
G0028_RS00290	COG2819	hydrolase of the alpha beta superfamily
G0028_RS00305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G0028_RS00310	COG0584	glycerophosphoryl diester phosphodiesterase
G0028_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS00325	COG0546	phosphoglycolate phosphatase activity
G0028_RS00330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G0028_RS00355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G0028_RS00390	COG3023	N-Acetylmuramoyl-L-alanine amidase
G0028_RS00460	COG1596	polysaccharide export
G0028_RS00465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G0028_RS00475	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G0028_RS00495	COG1216	Glycosyl transferase, family 2
G0028_RS00495	COG0463	Glycosyl transferase, family 2
G0028_RS00510	COG1215	transferase activity, transferring glycosyl groups
G0028_RS00520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G0028_RS00525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G0028_RS00540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G0028_RS00550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G0028_RS00580	COG0768	penicillin binding
G0028_RS00600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G0028_RS00605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G0028_RS00610	COG4451	ribulose bisphosphate carboxylase, small
G0028_RS00610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G0028_RS00615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G0028_RS00620	COG1469	GTP cyclohydrolase I activity
G0028_RS00630	COG0215	cysteine-tRNA ligase activity
G0028_RS00645	COG0523	cobalamin synthesis protein
G0028_RS00675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G0028_RS00730	COG1294	oxidase, subunit
G0028_RS00735	COG1271	oxidase subunit
G0028_RS00765	COG0745	RESPONSE REGULATOR receiver
G0028_RS00795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G0028_RS00805	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G0028_RS00810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G0028_RS00835	COG3830	Belongs to the UPF0237 family
G0028_RS00835	COG0560	Phosphoserine phosphatase
G0028_RS00880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G0028_RS00940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G0028_RS00945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G0028_RS00955	COG0534	Mate efflux family protein
G0028_RS00960	COG0436	Aminotransferase
G0028_RS00965	COG2733	membrane
G0028_RS00980	COG2918	glutathione biosynthetic process
G0028_RS00995	COG3150	esterase
G0028_RS01020	COG3047	cAMP biosynthetic process
G0028_RS01050	COG1519	Transferase
G0028_RS01055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G0028_RS01060	COG0668	transmembrane transport
G0028_RS01070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G0028_RS01090	COG0431	NADPH-dependent FMN reductase
G0028_RS01115	COG0281	malic enzyme
G0028_RS01135	COG2837	iron assimilation
G0028_RS01145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G0028_RS01150	COG1121	(ABC) transporter
G0028_RS01190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G0028_RS01230	COG0386	Belongs to the glutathione peroxidase family
G0028_RS01250	COG1309	transcriptional regulator
G0028_RS01255	COG0697	spore germination
G0028_RS01265	COG0758	DNA mediated transformation
G0028_RS01270	COG1652	LysM domain
G0028_RS01300	COG1309	transcriptional regulator
G0028_RS01335	COG2814	Major facilitator Superfamily
G0028_RS01340	COG0666	response to abiotic stimulus
G0028_RS01350	COG2814	Major facilitator Superfamily
G0028_RS01380	COG4452	Inner membrane protein CreD
G0028_RS01385	COG2205	protein histidine kinase activity
G0028_RS01390	COG0745	RESPONSE REGULATOR receiver
G0028_RS01395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G0028_RS01420	COG1253	flavin adenine dinucleotide binding
G0028_RS01470	COG0067	glutamate synthase
G0028_RS01470	COG0069	glutamate synthase activity
G0028_RS01470	COG0070	glutamate synthase
G0028_RS01475	COG0493	'glutamate synthase
G0028_RS01485	COG1320	monovalent cation:proton antiporter activity
G0028_RS01490	COG2212	antiporter activity
G0028_RS01495	COG1863	multisubunit Na H antiporter MnhE subunit
G0028_RS01500	COG0651	ATP synthesis coupled electron transport
G0028_RS01505	COG1006	Multisubunit Na H antiporter MnhC subunit
G0028_RS01510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G0028_RS01510	COG2111	Na H antiporter
G0028_RS01535	COG2056	Na+-H+ antiporter family
G0028_RS01550	COG0326	Molecular chaperone. Has ATPase activity
G0028_RS01570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G0028_RS01585	COG0183	Belongs to the thiolase family
G0028_RS01590	COG1250	3-hydroxyacyl-CoA dehydrogenase
G0028_RS01590	COG1024	Enoyl-CoA hydratase
G0028_RS01630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G0028_RS01640	COG1132	(ABC) transporter
G0028_RS01655	COG2249	NAD(P)H dehydrogenase (quinone) activity
G0028_RS01695	COG0606	chelatase, subunit chli
G0028_RS01730	COG0745	RESPONSE REGULATOR receiver
G0028_RS01735	COG5002	protein histidine kinase activity
G0028_RS01745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G0028_RS01750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G0028_RS01770	COG0347	Belongs to the P(II) protein family
G0028_RS01775	COG0004	ammonium transporteR
G0028_RS01785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G0028_RS01785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G0028_RS01800	COG0586	Pfam SNARE associated Golgi protein
G0028_RS01825	COG0795	lipopolysaccharide-transporting ATPase activity
G0028_RS01830	COG0795	lipopolysaccharide-transporting ATPase activity
G0028_RS01835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G0028_RS01840	COG0793	Belongs to the peptidase S41A family
G0028_RS01855	COG2197	response regulator
G0028_RS01860	COG1686	Belongs to the peptidase S11 family
G0028_RS01865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G0028_RS01875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G0028_RS01880	COG4974	Belongs to the 'phage' integrase family
G0028_RS01905	COG0772	Belongs to the SEDS family
G0028_RS01915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G0028_RS01920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G0028_RS01925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G0028_RS01930	COG0494	nUDIX hydrolase
G0028_RS01935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G0028_RS01950	COG0704	Plays a role in the regulation of phosphate uptake
G0028_RS01965	COG3275	phosphorelay sensor kinase activity
G0028_RS01975	COG0181	hydroxymethylbilane synthase activity
G0028_RS02075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G0028_RS02080	COG0081	regulation of translation
G0028_RS02085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G0028_RS02090	COG0222	ribosome binding
G0028_RS02095	COG0085	RNA polymerase activity
G0028_RS02110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G0028_RS02130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G0028_RS02140	COG2226	methyltransferase
G0028_RS02160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G0028_RS02165	COG1074	ATP-dependent DNA helicase activity
G0028_RS02170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G0028_RS02175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G0028_RS02190	COG2841	Protein conserved in bacteria
G0028_RS02195	COG0598	Magnesium transport protein CorA
G0028_RS02215	COG0789	Transcriptional regulator
G0028_RS02230	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G0028_RS02240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G0028_RS02265	COG4535	Mg2 and Co2 transporter CorC
G0028_RS02270	COG0425	Belongs to the sulfur carrier protein TusA family
G0028_RS02285	COG0644	oxidoreductase
G0028_RS02285	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G0028_RS02295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G0028_RS02310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G0028_RS02320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G0028_RS02330	COG0493	'glutamate synthase
G0028_RS02350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G0028_RS02355	COG0254	rRNA binding
G0028_RS02360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G0028_RS02370	COG0534	Mate efflux family protein
G0028_RS02385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G0028_RS02415	COG1960	acyl-CoA dehydrogenase activity
G0028_RS02435	COG0408	coproporphyrinogen oxidase activity
G0028_RS02440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G0028_RS02460	COG0513	Belongs to the DEAD box helicase family
G0028_RS02465	COG1127	ABC transporter
G0028_RS02470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G0028_RS02475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G0028_RS02490	COG0598	Magnesium transport protein CorA
G0028_RS02500	COG0494	nUDIX hydrolase
G0028_RS02510	COG1040	competence protein
G0028_RS02515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G0028_RS02535	COG2937	Belongs to the GPAT DAPAT family
G0028_RS02540	COG1946	Acyl-CoA thioesterase
G0028_RS02545	COG1301	dicarboxylic acid transport
G0028_RS02565	COG1959	2 iron, 2 sulfur cluster binding
G0028_RS02570	COG1017	nitric oxide dioxygenase activity
G0028_RS02570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G0028_RS02575	COG0433	COG0433 Predicted ATPase
G0028_RS02590	COG0051	transcription antitermination factor activity, RNA binding
G0028_RS02595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G0028_RS02600	COG0088	Forms part of the polypeptide exit tunnel
G0028_RS02645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G0028_RS02655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G0028_RS02660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G0028_RS02665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G0028_RS02670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G0028_RS02680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G0028_RS02725	COG0203	ribosomal protein L17
G0028_RS02730	COG2072	flavoprotein involved in K transport
G0028_RS02750	COG1960	acyl-CoA dehydrogenase activity
G0028_RS02755	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G0028_RS02785	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G0028_RS02790	COG0339	signal peptide processing
G0028_RS02795	COG0557	exoribonuclease II activity
G0028_RS02825	COG0765	amino acid transport
G0028_RS02830	COG0765	amino acid transport
G0028_RS02835	COG1126	abc transporter atp-binding protein
G0028_RS02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G0028_RS02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G0028_RS02870	COG0179	Fumarylacetoacetate (FAA) hydrolase
G0028_RS02880	COG1295	ribonuclease BN
G0028_RS02900	COG1946	Acyl-CoA thioesterase
G0028_RS02930	COG0668	transmembrane transport
G0028_RS02940	COG1702	phosphate starvation-inducible protein PhoH
G0028_RS02945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G0028_RS02950	COG0741	lytic transglycosylase activity
G0028_RS02950	COG0739	heme binding
G0028_RS02950	COG1196	nuclear chromosome segregation
G0028_RS02990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G0028_RS02995	COG1183	phosphatidylcholine synthase activity
G0028_RS03030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G0028_RS03060	COG1607	acyl-coa hydrolase
G0028_RS03095	COG2350	Protein conserved in bacteria
G0028_RS03105	COG0613	PHP domain protein
G0028_RS03110	COG3781	membrane
G0028_RS03120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G0028_RS03125	COG3783	Cytochrome b(562)
G0028_RS03150	COG1162	GTPase activity
G0028_RS03155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G0028_RS03170	COG1538	Outer membrane efflux protein
G0028_RS03175	COG0577	efflux transmembrane transporter activity
G0028_RS03175	COG1136	(ABC) transporter
G0028_RS03180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G0028_RS03205	COG0028	Belongs to the TPP enzyme family
G0028_RS03210	COG0440	acetolactate synthase activity
G0028_RS03215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G0028_RS03260	COG1426	Protein conserved in bacteria
G0028_RS03280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G0028_RS03300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G0028_RS03305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G0028_RS03315	COG0318	PFAM AMP-dependent synthetase and ligase
G0028_RS03330	COG2986	histidine ammonia-lyase
G0028_RS03370	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS03375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G0028_RS03400	COG1862	Preprotein translocase
G0028_RS03425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G0028_RS03440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G0028_RS03455	COG0726	polysaccharide deacetylase
G0028_RS03475	COG0438	transferase activity, transferring glycosyl groups
G0028_RS03490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G0028_RS03550	COG1960	acyl-CoA dehydrogenase activity
G0028_RS03555	COG1960	acyl-CoA dehydrogenase activity
G0028_RS03565	COG2205	protein histidine kinase activity
G0028_RS03570	COG0745	RESPONSE REGULATOR receiver
G0028_RS03580	COG2315	Protein conserved in bacteria
G0028_RS03590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G0028_RS03610	COG2096	Adenosyltransferase
G0028_RS03615	COG4206	TonB-dependent receptor
G0028_RS03665	COG0183	Belongs to the thiolase family
G0028_RS03695	COG1690	Belongs to the RtcB family
G0028_RS03700	COG0833	amino acid
G0028_RS03710	COG2233	PERMEase
G0028_RS03715	COG1217	gtp-binding protein TYPA
G0028_RS03730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G0028_RS03745	COG4772	TonB-dependent receptor
G0028_RS03755	COG0679	Auxin Efflux Carrier
G0028_RS03760	COG1981	membrane
G0028_RS03770	COG3831	ATPase activity
G0028_RS03780	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G0028_RS03805	COG0714	Associated with various cellular activities
G0028_RS03840	COG0456	acetyltransferase
G0028_RS03845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G0028_RS03850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G0028_RS03855	COG0500	methyltransferase
G0028_RS03860	COG0492	ferredoxin-NADP+ reductase activity
G0028_RS03865	COG1674	ftsk spoiiie
G0028_RS03865	COG0531	amino acid
G0028_RS03870	COG1280	lysine exporter protein (LysE YggA)
G0028_RS03885	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G0028_RS03890	COG2894	cell division
G0028_RS03895	COG0850	regulation of cytokinetic process
G0028_RS03905	COG0204	Acyl-transferase
G0028_RS03910	COG2885	chlorophyll binding
G0028_RS03915	COG0210	DNA helicase
G0028_RS03920	COG0756	dUTP diphosphatase activity
G0028_RS03925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G0028_RS03940	COG0121	glutamine amidotransferase
G0028_RS03960	COG2914	Belongs to the UPF0125 (RnfH) family
G0028_RS03965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G0028_RS03970	COG0735	belongs to the Fur family
G0028_RS03985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G0028_RS04010	COG0420	3'-5' exonuclease activity
G0028_RS04030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G0028_RS04040	COG4676	Protein conserved in bacteria
G0028_RS04045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G0028_RS04075	COG0354	folic acid binding
G0028_RS04080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G0028_RS04125	COG0714	Associated with various cellular activities
G0028_RS04130	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G0028_RS04135	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G0028_RS04145	COG0564	pseudouridine synthase activity
G0028_RS04160	COG2824	Alkylphosphonate utilization operon protein PhnA
G0028_RS04180	COG0494	nUDIX hydrolase
G0028_RS04185	COG5342	invasion associated locus B
G0028_RS04190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G0028_RS04210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G0028_RS04220	COG3545	Serine hydrolase
G0028_RS04245	COG0730	response to heat
G0028_RS04255	COG1196	nuclear chromosome segregation
G0028_RS04265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G0028_RS04275	COG2193	ferroxidase activity
G0028_RS04285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G0028_RS04300	COG0596	Alpha beta hydrolase
G0028_RS04300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G0028_RS04300	COG2226	methyltransferase
G0028_RS04315	COG4106	trans-aconitate 2-methyltransferase activity
G0028_RS04335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G0028_RS04340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G0028_RS04350	COG0009	L-threonylcarbamoyladenylate synthase
G0028_RS04355	COG3101	peptidyl-lysine hydroxylation
G0028_RS04370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G0028_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS04385	COG1652	LysM domain
G0028_RS04390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G0028_RS04405	COG0745	RESPONSE REGULATOR receiver
G0028_RS04410	COG2205	protein histidine kinase activity
G0028_RS04420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G0028_RS04440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G0028_RS04450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G0028_RS04455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G0028_RS04465	COG0713	ATP synthesis coupled electron transport
G0028_RS04470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G0028_RS04475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G0028_RS04485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G0028_RS04495	COG0583	DNA-binding transcription factor activity
G0028_RS04515	COG0668	transmembrane transport
G0028_RS04530	COG2081	HI0933 family
G0028_RS04550	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G0028_RS04595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G0028_RS04595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G0028_RS04630	COG0489	protein tyrosine kinase activity
G0028_RS04675	COG0442	prolyl-tRNA aminoacylation
G0028_RS04700	COG0840	transmembrane signaling receptor activity
G0028_RS04705	COG2198	Histidine kinase
G0028_RS04705	COG0784	Response regulator, receiver
G0028_RS04705	COG0643	Histidine kinase
G0028_RS04785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G0028_RS04795	COG1289	transmembrane transporter activity
G0028_RS04800	COG2814	Major facilitator Superfamily
G0028_RS04815	COG0786	glutamate:sodium symporter activity
G0028_RS04820	COG1752	Esterase of the alpha-beta hydrolase superfamily
G0028_RS04830	COG1607	acyl-coa hydrolase
G0028_RS04840	COG2814	Major facilitator Superfamily
G0028_RS04845	COG0583	DNA-binding transcription factor activity
G0028_RS04865	COG0523	cobalamin synthesis protein
G0028_RS04870	COG4681	YaeQ
G0028_RS04880	COG0726	polysaccharide deacetylase
G0028_RS04880	COG1649	PFAM Uncharacterised BCR, COG1649
G0028_RS04885	COG1215	transferase activity, transferring glycosyl groups
G0028_RS04920	COG4771	TonB-dependent receptor
G0028_RS04955	COG1113	amino acid transport
G0028_RS04960	COG2828	Protein conserved in bacteria
G0028_RS04975	COG0242	peptide deformylase activity
G0028_RS04985	COG0210	DNA helicase
G0028_RS04995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G0028_RS05005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G0028_RS05020	COG0531	amino acid
G0028_RS05035	COG0321	lipoyl(octanoyl) transferase activity
G0028_RS05065	COG0586	Pfam SNARE associated Golgi protein
G0028_RS05090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G0028_RS05130	COG0306	phosphate transporter
G0028_RS05150	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G0028_RS05190	COG0583	DNA-binding transcription factor activity
G0028_RS05195	COG0697	spore germination
G0028_RS05205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G0028_RS05210	COG1024	Enoyl-CoA hydratase
G0028_RS05230	COG0142	geranyltranstransferase activity
G0028_RS05240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G0028_RS05255	COG1752	Esterase of the alpha-beta hydrolase superfamily
G0028_RS05280	COG0642	Histidine kinase
G0028_RS05295	COG0004	ammonium transporteR
G0028_RS05305	COG1538	Outer membrane efflux protein
G0028_RS05315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G0028_RS05320	COG0671	phosphoesterase, PA-phosphatase related
G0028_RS05335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G0028_RS05365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G0028_RS05375	COG1648	precorrin-2 dehydrogenase activity
G0028_RS05375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G0028_RS05380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G0028_RS05385	COG1794	racemase activity, acting on amino acids and derivatives
G0028_RS05400	COG1115	amino acid carrier protein
G0028_RS05405	COG1113	amino acid transport
G0028_RS05420	COG0019	diaminopimelate decarboxylase activity
G0028_RS05425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G0028_RS05430	COG3161	chorismate lyase activity
G0028_RS05435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G0028_RS05445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G0028_RS05455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G0028_RS05460	COG0602	queuosine metabolic process
G0028_RS05470	COG4625	pathogenesis
G0028_RS05480	COG0583	DNA-binding transcription factor activity
G0028_RS05485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G0028_RS05490	COG4208	sulfate ABC transporter
G0028_RS05495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G0028_RS05505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G0028_RS05510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G0028_RS05515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G0028_RS05535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G0028_RS05560	COG0571	ribonuclease III activity
G0028_RS05565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G0028_RS05575	COG1381	Involved in DNA repair and RecF pathway recombination
G0028_RS05580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G0028_RS05600	COG0415	Belongs to the DNA photolyase family
G0028_RS05610	COG1252	NADH dehydrogenase
G0028_RS05615	COG1686	Belongs to the peptidase S11 family
G0028_RS05630	COG2268	Band 7 protein
G0028_RS05635	COG1585	Membrane protein implicated in regulation of membrane protease activity
G0028_RS05645	COG2354	Protein conserved in bacteria
G0028_RS05650	COG2321	neutral zinc metallopeptidase
G0028_RS05690	COG0589	response to stress
G0028_RS05700	COG3107	peptidoglycan biosynthetic process
G0028_RS05735	COG1388	LysM domain
G0028_RS05735	COG0741	lytic transglycosylase activity
G0028_RS05740	COG4166	transmembrane transport
G0028_RS05745	COG4174	ABC transporter (Permease)
G0028_RS05750	COG4239	(ABC) transporter, permease
G0028_RS05755	COG4172	Belongs to the ABC transporter superfamily
G0028_RS05770	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
G0028_RS05780	COG0833	amino acid
G0028_RS05785	COG1671	Belongs to the UPF0178 family
G0028_RS05805	COG1136	(ABC) transporter
G0028_RS05810	COG0658	competence protein
G0028_RS05810	COG2333	competence protein COMEC
G0028_RS05825	COG0596	Alpha beta hydrolase
G0028_RS05840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G0028_RS05845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G0028_RS05850	COG0628	permease
G0028_RS05890	COG0138	bifunctional purine biosynthesis protein purh
G0028_RS05895	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G0028_RS05905	COG2264	protein methyltransferase activity
G0028_RS05945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G0028_RS05945	COG1116	anion transmembrane transporter activity
G0028_RS05955	COG2223	nitrite transmembrane transporter activity
G0028_RS05960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G0028_RS05965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G0028_RS05970	COG0243	molybdopterin cofactor binding
G0028_RS05980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G0028_RS05990	COG0314	molybdopterin synthase activity
G0028_RS05995	COG0521	Mo-molybdopterin cofactor biosynthetic process
G0028_RS05995	COG0315	cyclic pyranopterin monophosphate synthase activity
G0028_RS06000	COG0303	'Molybdopterin
G0028_RS06005	COG0725	ABC transporter, periplasmic molybdate-binding protein
G0028_RS06010	COG4149	molybdate abc transporter
G0028_RS06015	COG0235	Class ii aldolase
G0028_RS06020	COG1741	Belongs to the pirin family
G0028_RS06035	COG3739	integral membrane protein
G0028_RS06050	COG3706	GGDEF domain
G0028_RS06065	COG0302	gtp cyclohydrolase
G0028_RS06085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G0028_RS06090	COG0512	Glutamine amidotransferase of anthranilate synthase
G0028_RS06150	COG4197	protein conserved in bacteria, prophage-related
G0028_RS06385	COG3179	chitinase
G0028_RS06395	COG0582	viral genome integration into host DNA
G0028_RS06410	COG0174	glutamine synthetase
G0028_RS06420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G0028_RS06430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G0028_RS06480	COG1024	Enoyl-CoA hydratase
G0028_RS06485	COG1051	belongs to the nudix hydrolase family
G0028_RS06485	COG1056	cytidyltransferase-related domain
G0028_RS06500	COG1309	transcriptional regulator
G0028_RS06505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G0028_RS06520	COG0671	phosphoesterase, PA-phosphatase related
G0028_RS06530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G0028_RS06535	COG0076	glutamate decarboxylase activity
G0028_RS06540	COG1522	sequence-specific DNA binding
G0028_RS06545	COG3961	Belongs to the TPP enzyme family
G0028_RS06550	COG1113	amino acid transport
G0028_RS06560	COG1704	LemA family
G0028_RS06565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G0028_RS06580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G0028_RS06595	COG2252	PERMEase
G0028_RS06600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G0028_RS06610	COG3038	cytochrome b561
G0028_RS06620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G0028_RS06630	COG0527	aspartate kinase activity
G0028_RS06640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G0028_RS06655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G0028_RS06660	COG1522	sequence-specific DNA binding
G0028_RS06670	COG0726	polysaccharide deacetylase
G0028_RS06670	COG1649	PFAM Uncharacterised BCR, COG1649
G0028_RS06675	COG1215	transferase activity, transferring glycosyl groups
G0028_RS06685	COG4682	membrane
G0028_RS06690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G0028_RS06705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G0028_RS06710	COG2890	protein-(glutamine-N5) methyltransferase activity
G0028_RS06715	COG0625	glutathione transferase activity
G0028_RS06735	COG2363	Small membrane protein
G0028_RS06745	COG0425	Belongs to the sulfur carrier protein TusA family
G0028_RS06750	COG1278	Cold shock
G0028_RS06755	COG0513	Belongs to the DEAD box helicase family
G0028_RS06790	COG0167	dihydroorotate dehydrogenase activity
G0028_RS06795	COG1286	toxin biosynthetic process
G0028_RS06830	COG1610	YqeY-like protein
G0028_RS06850	COG2059	Chromate
G0028_RS06900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G0028_RS06925	COG0494	nUDIX hydrolase
G0028_RS06935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G0028_RS06940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G0028_RS06945	COG3139	Protein of unknown function (DUF1315)
G0028_RS06955	COG1301	dicarboxylic acid transport
G0028_RS06965	COG0667	Aldo Keto reductase
G0028_RS06975	COG1765	OsmC-like protein
G0028_RS06985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G0028_RS06990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G0028_RS07000	COG1045	serine acetyltransferase
G0028_RS07005	COG0542	response to heat
G0028_RS07060	COG0582	viral genome integration into host DNA
G0028_RS07065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G0028_RS07085	COG5295	Hep Hag repeat protein
G0028_RS07085	COG5295	Hep Hag repeat protein
G0028_RS07095	COG0477	Major facilitator Superfamily
G0028_RS07100	COG0729	surface antigen
G0028_RS07165	COG1113	amino acid transport
G0028_RS07170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G0028_RS07175	COG2707	UPF0756 membrane protein
G0028_RS07180	COG1187	pseudouridine synthase activity
G0028_RS07200	COG0802	atpase or kinase
G0028_RS07205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G0028_RS07215	COG1923	regulation of RNA biosynthetic process
G0028_RS07220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G0028_RS07230	COG3178	'Phosphotransferase
G0028_RS07235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G0028_RS07245	COG1192	Involved in chromosome partitioning
G0028_RS07250	COG1475	DNA binding
G0028_RS07255	COG0811	peptide transport
G0028_RS07265	COG1132	(ABC) transporter
G0028_RS07270	COG1663	tetraacyldisaccharide 4'-kinase activity
G0028_RS07290	COG0084	hydrolase, TatD family'
G0028_RS07325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G0028_RS07375	COG2431	L-lysine efflux transmembrane transporter activity
G0028_RS07390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G0028_RS07395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G0028_RS07415	COG0583	DNA-binding transcription factor activity
G0028_RS07420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G0028_RS07430	COG0583	DNA-binding transcription factor activity
G0028_RS07435	COG1960	acyl-CoA dehydrogenase activity
G0028_RS07440	COG2814	Major facilitator Superfamily
G0028_RS07650	COG5410	chromosome segregation
G0028_RS07820	COG0582	viral genome integration into host DNA
G0028_RS07835	COG1253	flavin adenine dinucleotide binding
G0028_RS07860	COG0024	Methionine aminopeptidase
G0028_RS07880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G0028_RS07905	COG3852	Histidine kinase
G0028_RS07920	COG0233	cytoplasmic translational termination
G0028_RS07925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G0028_RS07930	COG0575	Belongs to the CDS family
G0028_RS07945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G0028_RS07965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G0028_RS07980	COG2137	regulation of response to DNA damage stimulus
G0028_RS07985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G0028_RS07990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G0028_RS07995	COG1011	Hydrolase
G0028_RS08015	COG0430	RNA-3'-phosphate cyclase activity
G0028_RS08045	COG1690	Belongs to the RtcB family
G0028_RS08075	COG4650	regulator
G0028_RS08150	COG0540	Belongs to the ATCase OTCase family
G0028_RS08160	COG2072	flavoprotein involved in K transport
G0028_RS08180	COG1960	acyl-CoA dehydrogenase activity
G0028_RS08185	COG0183	Belongs to the thiolase family
G0028_RS08190	COG0427	acetyl-CoA hydrolase
G0028_RS08210	COG0517	IMP dehydrogenase activity
G0028_RS08210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G0028_RS08215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G0028_RS08225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G0028_RS08230	COG1137	ATPase activity
G0028_RS08255	COG4122	O-methyltransferase activity
G0028_RS08265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G0028_RS08330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G0028_RS08345	COG3698	Phosphodiester glycosidase
G0028_RS08350	COG2871	sodium ion transport
G0028_RS08405	COG0424	maF-like protein
G0028_RS08430	COG0697	spore germination
G0028_RS08485	COG0730	response to heat
G0028_RS08490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G0028_RS08510	COG0477	Major facilitator Superfamily
G0028_RS08515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G0028_RS08525	COG1960	acyl-CoA dehydrogenase activity
G0028_RS08530	COG1960	acyl-CoA dehydrogenase activity
G0028_RS08570	COG1546	Belongs to the CinA family
G0028_RS08570	COG1058	Belongs to the CinA family
G0028_RS08580	COG0589	response to stress
G0028_RS08595	COG2031	fatty acid transporter
G0028_RS08600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G0028_RS08615	COG4770	biotin carboxylase activity
G0028_RS08620	COG1024	Enoyl-CoA hydratase
G0028_RS08625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G0028_RS08635	COG1309	transcriptional regulator
G0028_RS08640	COG0318	PFAM AMP-dependent synthetase and ligase
G0028_RS08650	COG2937	Belongs to the GPAT DAPAT family
G0028_RS08655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G0028_RS08675	COG1720	tRNA m6t6A37 methyltransferase activity
G0028_RS08700	COG0582	viral genome integration into host DNA
G0028_RS08740	COG0582	viral genome integration into host DNA
G0028_RS08815	COG0308	aminopeptidase N
G0028_RS08825	COG1203	CRISPR-associated helicase, Cas3
G0028_RS08870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G0028_RS08870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G0028_RS08870	COG0506	proline dehydrogenase activity
G0028_RS08885	COG0307	riboflavin synthase, alpha
G0028_RS08890	COG0318	PFAM AMP-dependent synthetase and ligase
G0028_RS08910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G0028_RS08910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G0028_RS08950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G0028_RS08970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G0028_RS08975	COG0542	response to heat
G0028_RS08985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G0028_RS09005	COG0668	transmembrane transport
G0028_RS09010	COG2353	YceI-like domain
G0028_RS09170	COG5410	chromosome segregation
G0028_RS09315	COG2323	membrane
G0028_RS09325	COG0519	Catalyzes the synthesis of GMP from XMP
G0028_RS09325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G0028_RS09360	COG1454	alcohol dehydrogenase
G0028_RS09370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G0028_RS09385	COG0537	adenosine 5'-monophosphoramidase activity
G0028_RS09415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G0028_RS09445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G0028_RS09455	COG0133	tryptophan synthase activity
G0028_RS09460	COG0517	IMP dehydrogenase activity
G0028_RS09490	COG0612	Peptidase, M16
G0028_RS09495	COG0552	protein localization to endoplasmic reticulum
G0028_RS09515	COG4589	Belongs to the CDS family
G0028_RS09530	COG2814	Major facilitator Superfamily
G0028_RS09535	COG0509	glycine decarboxylation via glycine cleavage system
G0028_RS09550	COG1132	(ABC) transporter
G0028_RS09585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G0028_RS09625	COG1271	oxidase subunit
G0028_RS09630	COG1294	oxidase, subunit
G0028_RS09645	COG1960	acyl-CoA dehydrogenase activity
G0028_RS09685	COG3327	negative regulation of DNA-templated transcription, initiation
G0028_RS09690	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
G0028_RS09695	COG0183	Belongs to the thiolase family
G0028_RS09700	COG1250	3-hydroxyacyl-CoA dehydrogenase
G0028_RS09705	COG1024	Enoyl-CoA hydratase
G0028_RS09710	COG1024	Enoyl-CoA hydratase
G0028_RS09715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G0028_RS09720	COG2151	metal-sulfur cluster biosynthetic enzyme
G0028_RS09725	COG3396	Phenylacetate-CoA oxygenase
G0028_RS09730	COG3460	Phenylacetate-CoA oxygenase
G0028_RS09735	COG3396	Phenylacetate-CoA oxygenase
G0028_RS09740	COG2030	dehydratase
G0028_RS09740	COG1012	belongs to the aldehyde dehydrogenase family
G0028_RS09750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G0028_RS09765	COG1944	ATP diphosphatase activity
G0028_RS09775	COG0583	DNA-binding transcription factor activity
G0028_RS09895	COG1535	isochorismatase
G0028_RS09895	COG3433	isochorismatase activity
G0028_RS09905	COG1169	isochorismate synthase
G0028_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS09920	COG0730	response to heat
G0028_RS09925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G0028_RS09930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G0028_RS09940	COG0789	Transcriptional regulator
G0028_RS09955	COG0583	DNA-binding transcription factor activity
G0028_RS09965	COG1619	proteins homologs of microcin C7 resistance protein MccF
G0028_RS09970	COG1024	Enoyl-CoA hydratase
G0028_RS09975	COG1024	Enoyl-CoA hydratase
G0028_RS09980	COG1960	acyl-CoA dehydrogenase activity
G0028_RS09985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G0028_RS10000	COG0583	DNA-binding transcription factor activity
G0028_RS10010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G0028_RS10020	COG0745	RESPONSE REGULATOR receiver
G0028_RS10050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G0028_RS10080	COG1696	Membrane protein involved in D-alanine export
G0028_RS10100	COG0583	DNA-binding transcription factor activity
G0028_RS10105	COG1380	Effector of murein hydrolase LrgA
G0028_RS10110	COG1346	cytolysis
G0028_RS10125	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G0028_RS10195	COG0511	ligase activity, forming carbon-carbon bonds
G0028_RS10210	COG2199	diguanylate cyclase activity
G0028_RS10215	COG2814	Major facilitator Superfamily
G0028_RS10230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G0028_RS10240	COG0596	Alpha beta hydrolase
G0028_RS10255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G0028_RS10260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G0028_RS10300	COG2814	Major facilitator Superfamily
G0028_RS10305	COG0583	DNA-binding transcription factor activity
G0028_RS10315	COG4638	Rieske (2fe-2S)
G0028_RS10320	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G0028_RS10325	COG0633	Ferredoxin
G0028_RS10325	COG0543	2 iron, 2 sulfur cluster binding
G0028_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS10335	COG3135	benzoate transporter
G0028_RS10350	COG2304	oxidoreductase activity
G0028_RS10390	COG1358	cellular component organization or biogenesis
G0028_RS10425	COG4245	von Willebrand factor, type A
G0028_RS10450	COG0431	NADPH-dependent FMN reductase
G0028_RS10455	COG0798	PFAM Bile acid sodium symporter
G0028_RS10460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G0028_RS10465	COG0640	Transcriptional regulator
G0028_RS10470	COG0826	peptidase U32
G0028_RS10475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G0028_RS10480	COG1464	Belongs to the NlpA lipoprotein family
G0028_RS10485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G0028_RS10490	COG2011	ABC-type metal ion transport system permease component
G0028_RS10495	COG2850	peptidyl-arginine hydroxylation
G0028_RS10500	COG3615	Tellurite resistance protein tehB
G0028_RS10500	COG0500	methyltransferase
G0028_RS10505	COG0069	glutamate synthase activity
G0028_RS10520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G0028_RS10540	COG0772	Belongs to the SEDS family
G0028_RS10550	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G0028_RS10565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G0028_RS10590	COG1902	pentaerythritol trinitrate reductase activity
G0028_RS10590	COG0446	pyridine nucleotide-disulphide oxidoreductase
G0028_RS10605	COG0583	DNA-binding transcription factor activity
G0028_RS10610	COG0386	Belongs to the glutathione peroxidase family
G0028_RS10615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G0028_RS10620	COG0436	Aminotransferase
G0028_RS10665	COG0583	DNA-binding transcription factor activity
G0028_RS10670	COG4948	Mandelate Racemase Muconate Lactonizing
G0028_RS10675	COG4829	muconolactone delta-isomerase
G0028_RS10685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G0028_RS10690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G0028_RS10695	COG0183	Belongs to the thiolase family
G0028_RS10700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G0028_RS10745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G0028_RS10750	COG1454	alcohol dehydrogenase
G0028_RS10755	COG0824	Thioesterase
G0028_RS10790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G0028_RS10795	COG2207	Transcriptional regulator
G0028_RS10800	COG0372	Belongs to the citrate synthase family
G0028_RS10835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G0028_RS10840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G0028_RS10880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G0028_RS10885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G0028_RS10885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G0028_RS10900	COG3842	ATPase activity
G0028_RS10905	COG1840	ABC-type Fe3 transport system, periplasmic component
G0028_RS10925	COG0569	domain protein
G0028_RS10930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G0028_RS10950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G0028_RS10960	COG1585	Membrane protein implicated in regulation of membrane protease activity
G0028_RS10980	COG1294	oxidase, subunit
G0028_RS10985	COG4890	Cyd operon protein YbgT
G0028_RS11020	COG0436	Aminotransferase
G0028_RS11025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G0028_RS11080	COG1464	Belongs to the NlpA lipoprotein family
G0028_RS11085	COG1464	Belongs to the NlpA lipoprotein family
G0028_RS11090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G0028_RS11095	COG2011	ABC-type metal ion transport system permease component
G0028_RS11105	COG0012	GTP binding
G0028_RS11115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G0028_RS11120	COG0776	regulation of translation
G0028_RS11135	COG1959	2 iron, 2 sulfur cluster binding
G0028_RS11145	COG0822	iron-sulfur transferase activity
G0028_RS11150	COG0316	Belongs to the HesB IscA family
G0028_RS11180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G0028_RS11200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G0028_RS11205	COG0702	epimerase
G0028_RS11220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G0028_RS11230	COG0693	protein deglycase activity
G0028_RS11235	COG1960	acyl-CoA dehydrogenase activity
G0028_RS11315	COG0582	viral genome integration into host DNA
G0028_RS11335	COG3772	lysozyme
G0028_RS11395	COG3646	Phage regulatory protein
G0028_RS11400	COG3561	AntA/AntB antirepressor
G0028_RS11495	COG1783	phage Terminase large subunit
G0028_RS11500	COG3728	DNA packaging
G0028_RS11580	COG2932	Transcriptional regulator
G0028_RS11600	COG3723	Recombinational DNA repair protein, rece pathway
G0028_RS11665	COG0714	Associated with various cellular activities
G0028_RS11670	COG2879	small protein
G0028_RS11675	COG1966	Carbon starvation protein
G0028_RS11680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G0028_RS11685	COG1509	lysine 2,3-aminomutase activity
G0028_RS11720	COG1067	ATP-dependent peptidase activity
G0028_RS11725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G0028_RS11735	COG0573	inorganic phosphate transmembrane transporter activity
G0028_RS11775	COG1643	Atp-dependent helicase
G0028_RS11815	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
G0028_RS11830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G0028_RS11840	COG2351	hydroxyisourate hydrolase activity
G0028_RS11845	COG2233	PERMEase
G0028_RS11900	COG2391	methyltransferase activity
G0028_RS11915	COG2070	2-Nitropropane dioxygenase
G0028_RS11920	COG2318	DinB family
G0028_RS11930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G0028_RS11935	COG2199	diguanylate cyclase activity
G0028_RS11950	COG0352	thiamine-phosphate diphosphorylase activity
G0028_RS11960	COG2801	Transposase and inactivated derivatives
G0028_RS12075	COG0582	viral genome integration into host DNA
G0028_RS12080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G0028_RS12090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G0028_RS12095	COG1733	regulation of RNA biosynthetic process
G0028_RS12100	COG0702	epimerase
G0028_RS12135	COG0556	nucleotide-excision repair
G0028_RS12155	COG5001	Diguanylate cyclase
G0028_RS12165	COG0436	Aminotransferase
G0028_RS12170	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
G0028_RS12180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G0028_RS12210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G0028_RS12215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G0028_RS12220	COG1845	cytochrome c oxidase, subunit III
G0028_RS12225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G0028_RS12240	COG0360	Binds together with S18 to 16S ribosomal RNA
G0028_RS12245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G0028_RS12255	COG0305	Participates in initiation and elongation during chromosome replication
G0028_RS12270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G0028_RS12280	COG1305	Transglutaminase-like
G0028_RS12290	COG2308	Evidence 4 Homologs of previously reported genes of
G0028_RS12315	COG0612	Peptidase, M16
G0028_RS12330	COG1823	symporter activity
G0028_RS12350	COG1187	pseudouridine synthase activity
G0028_RS12355	COG2050	protein possibly involved in aromatic compounds catabolism
G0028_RS12370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G0028_RS12380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G0028_RS12390	COG0281	malic enzyme
G0028_RS12390	COG0280	phosphate acetyltransferase
G0028_RS12415	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G0028_RS12425	COG3706	GGDEF domain
G0028_RS12425	COG5001	Diguanylate cyclase
G0028_RS12425	COG2203	Gaf domain
G0028_RS12425	COG4251	negative regulation of phosphorylation
G0028_RS12435	COG0418	dihydroorotase activity
G0028_RS12440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G0028_RS12460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G0028_RS12470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G0028_RS12485	COG1301	dicarboxylic acid transport
G0028_RS12505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G0028_RS12505	COG0047	phosphoribosylformylglycinamidine synthase activity
G0028_RS12510	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
G0028_RS12555	COG0824	Thioesterase
G0028_RS12580	COG2814	Major facilitator Superfamily
G0028_RS12585	COG1846	Transcriptional regulator
G0028_RS12595	COG0477	Major facilitator Superfamily
G0028_RS12610	COG3971	2-oxopent-4-enoate hydratase activity
G0028_RS12620	COG3384	dioxygenase
G0028_RS12625	COG1012	belongs to the aldehyde dehydrogenase family
G0028_RS12635	COG0179	Fumarylacetoacetate (FAA) hydrolase
G0028_RS12640	COG2207	Transcriptional regulator
G0028_RS12655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G0028_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS12690	COG0154	amidase activity
G0028_RS12700	COG1250	3-hydroxyacyl-CoA dehydrogenase
G0028_RS12715	COG2814	Major facilitator Superfamily
G0028_RS12725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G0028_RS12730	COG1960	acyl-CoA dehydrogenase activity
G0028_RS12740	COG2814	Major facilitator Superfamily
G0028_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS12755	COG1942	4-Oxalocrotonate Tautomerase
G0028_RS12770	COG1960	acyl-CoA dehydrogenase activity
G0028_RS12810	COG1902	pentaerythritol trinitrate reductase activity
G0028_RS12810	COG0446	pyridine nucleotide-disulphide oxidoreductase
G0028_RS12830	COG0277	FAD linked oxidase domain protein
G0028_RS12840	COG2186	Transcriptional regulator
G0028_RS12875	COG1131	(ABC) transporter
G0028_RS12880	COG0842	Transport permease protein
G0028_RS12900	COG2951	lytic endotransglycosylase activity
G0028_RS12930	COG0052	Belongs to the universal ribosomal protein uS2 family
G0028_RS12950	COG0583	DNA-binding transcription factor activity
G0028_RS12965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G0028_RS12970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G0028_RS12990	COG0833	amino acid
G0028_RS13000	COG0482	sulfurtransferase activity
G0028_RS13005	COG2915	High frequency lysogenization protein hflD homolog
G0028_RS13030	COG0616	signal peptide processing
G0028_RS13035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G0028_RS13040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G0028_RS13065	COG1686	Belongs to the peptidase S11 family
G0028_RS13070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G0028_RS13075	COG0823	Involved in the tonB-independent uptake of proteins
G0028_RS13095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G0028_RS13170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G0028_RS13175	COG1773	rubredoxin
G0028_RS13180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G0028_RS13185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G0028_RS13190	COG0583	DNA-binding transcription factor activity
G0028_RS13215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G0028_RS13220	COG4181	ATPase activity
G0028_RS13230	COG0560	Phosphoserine phosphatase
G0028_RS13240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G0028_RS13255	COG0424	maF-like protein
G0028_RS13260	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G0028_RS13265	COG1792	Involved in formation and maintenance of cell shape
G0028_RS13270	COG1077	Cell shape determining protein MreB Mrl
G0028_RS13275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G0028_RS13285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G0028_RS13320	COG3015	lipoprotein NlpE involved in copper resistance
G0028_RS13335	COG1253	flavin adenine dinucleotide binding
G0028_RS13355	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS13365	COG0525	valine-tRNA ligase activity
G0028_RS13380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G0028_RS13385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G0028_RS13395	COG0037	tRNA processing
G0028_RS13400	COG0739	heme binding
G0028_RS13400	COG0741	lytic transglycosylase activity
G0028_RS13400	COG1196	nuclear chromosome segregation
G0028_RS13405	COG0501	Belongs to the peptidase M48B family
G0028_RS13420	COG2239	Acts as a magnesium transporter
G0028_RS13425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G0028_RS13450	COG0459	protein refolding
G0028_RS13460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G0028_RS13465	COG1597	lipid kinase activity
G0028_RS13470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G0028_RS13505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G0028_RS13535	COG2304	oxidoreductase activity
G0028_RS13540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G0028_RS13545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G0028_RS13550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G0028_RS13565	COG0505	Belongs to the CarA family
G0028_RS13580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G0028_RS13595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G0028_RS13600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G0028_RS13610	COG0006	proline dipeptidase activity
G0028_RS13635	COG2175	clavaminate synthase activity
G0028_RS13640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G0028_RS13645	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G0028_RS13650	COG4521	taurine ABC transporter
G0028_RS13680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G0028_RS13700	COG3384	dioxygenase
G0028_RS13720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G0028_RS13725	COG2878	Part of a membrane complex involved in electron transport
G0028_RS13730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G0028_RS13760	COG0768	penicillin binding
G0028_RS13765	COG0742	ribosomal rna small subunit methyltransferase
G0028_RS13785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G0028_RS13790	COG0045	succinate-CoA ligase (ADP-forming) activity
G0028_RS13795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G0028_RS13810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G0028_RS13815	COG1053	succinate dehydrogenase
G0028_RS13820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G0028_RS13825	COG2009	succinate dehydrogenase
G0028_RS13855	COG0300	oxidoreductase activity
G0028_RS13870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G0028_RS13870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G0028_RS13910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G0028_RS13920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G0028_RS13940	COG0564	pseudouridine synthase activity
G0028_RS13950	COG0358	DNA primase activity
G0028_RS13965	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G0028_RS13995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G0028_RS14030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G0028_RS14040	COG0582	viral genome integration into host DNA
G0028_RS14060	COG3772	lysozyme
G0028_RS14160	COG4387	Mu-like prophage protein GP36
G0028_RS14195	COG4383	Mu-like prophage protein gp29
G0028_RS14285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G0028_RS14305	COG3723	Recombinational DNA repair protein, rece pathway
G0028_RS14375	COG3209	COG3209 Rhs family protein
G0028_RS14390	COG2161	toxin-antitoxin pair type II binding
G0028_RS14760	COG0582	viral genome integration into host DNA
G0028_RS14765	COG0372	Belongs to the citrate synthase family
G0028_RS14775	COG0318	PFAM AMP-dependent synthetase and ligase
G0028_RS14795	COG2855	membrane
G0028_RS14815	COG3246	L-lysine catabolic process to acetate
G0028_RS14820	COG2175	clavaminate synthase activity
G0028_RS14830	COG0583	DNA-binding transcription factor activity
G0028_RS14840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G0028_RS14845	COG2814	Major facilitator Superfamily
G0028_RS14855	COG2050	protein possibly involved in aromatic compounds catabolism
G0028_RS14865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G0028_RS14870	COG1090	epimerase
G0028_RS14900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G0028_RS14900	COG0352	thiamine-phosphate diphosphorylase activity
G0028_RS14900	COG0351	phosphomethylpyrimidine kinase
G0028_RS14905	COG3706	GGDEF domain
G0028_RS14930	COG2076	Multidrug Resistance protein
G0028_RS14940	COG2132	Multicopper oxidase
G0028_RS14950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G0028_RS14965	COG4269	membrane
G0028_RS14985	COG1968	undecaprenyl-diphosphatase activity
G0028_RS14990	COG1214	PFAM Peptidase M22, glycoprotease
G0028_RS14995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G0028_RS15000	COG0494	nUDIX hydrolase
G0028_RS15060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G0028_RS15065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G0028_RS15090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G0028_RS15095	COG0765	amino acid transport
G0028_RS15100	COG0765	amino acid transport
G0028_RS15105	COG1126	abc transporter atp-binding protein
G0028_RS15145	COG2199	diguanylate cyclase activity
G0028_RS15150	COG2885	chlorophyll binding
G0028_RS15175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G0028_RS15180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G0028_RS15195	COG0450	alkyl hydroperoxide reductase
G0028_RS15205	COG0625	glutathione transferase activity
G0028_RS15225	COG0285	dihydrofolate synthase activity
G0028_RS15270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G0028_RS15275	COG2207	Transcriptional regulator
G0028_RS15285	COG0183	Belongs to the thiolase family
G0028_RS15300	COG0546	phosphoglycolate phosphatase activity
G0028_RS15305	COG2153	protein acetylation
G0028_RS15315	COG1272	protein, Hemolysin III
G0028_RS15320	COG0477	Major facilitator Superfamily
G0028_RS15325	COG1408	metallophosphoesterase
G0028_RS15330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G0028_RS15340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G0028_RS15350	COG1346	cytolysis
G0028_RS15365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G0028_RS15370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G0028_RS15380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G0028_RS15385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G0028_RS15390	COG0625	glutathione transferase activity
G0028_RS15395	COG2969	positive regulation of protein catabolic process
G0028_RS15425	COG1024	Enoyl-CoA hydratase
G0028_RS15430	COG1960	acyl-CoA dehydrogenase activity
G0028_RS15435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G0028_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS15450	COG1309	transcriptional regulator
G0028_RS15470	COG1960	acyl-CoA dehydrogenase activity
G0028_RS15475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G0028_RS15525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G0028_RS15530	COG1764	response to oxidative stress
G0028_RS15580	COG0037	tRNA processing
G0028_RS15590	COG0248	Ppx GppA phosphatase
G0028_RS15610	COG0776	regulation of translation
G0028_RS15615	COG0072	phenylalanine-tRNA ligase activity
G0028_RS15620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G0028_RS15660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G0028_RS15675	COG1238	metal cluster binding
G0028_RS15685	COG0625	glutathione transferase activity
G0028_RS15700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G0028_RS15710	COG0318	PFAM AMP-dependent synthetase and ligase
G0028_RS15715	COG3028	Belongs to the UPF0307 family
G0028_RS15725	COG1660	Displays ATPase and GTPase activities
G0028_RS15730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G0028_RS15735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G0028_RS15740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G0028_RS15745	COG0617	tRNA 3'-terminal CCA addition
G0028_RS15750	COG1555	photosystem II stabilization
G0028_RS15750	COG1596	polysaccharide export
G0028_RS15755	COG3956	TIGRFAM MazG family protein
G0028_RS15765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G0028_RS15785	COG0784	Response regulator, receiver
G0028_RS15785	COG2205	protein histidine kinase activity
G0028_RS15785	COG5002	protein histidine kinase activity
G0028_RS15790	COG1024	Enoyl-CoA hydratase
G0028_RS15795	COG2084	Dehydrogenase
G0028_RS15800	COG3622	Belongs to the hyi family
G0028_RS15825	COG1053	succinate dehydrogenase
G0028_RS15825	COG3976	FMN-binding domain protein
G0028_RS15865	COG2814	Major facilitator Superfamily
G0028_RS15980	COG4626	Terminase
G0028_RS15980	COG1802	Transcriptional regulator
G0028_RS16035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G0028_RS16095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G0028_RS16115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G0028_RS16125	COG0084	hydrolase, TatD family'
G0028_RS16140	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G0028_RS16150	COG0793	Belongs to the peptidase S41A family
G0028_RS16180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G0028_RS16185	COG0857	belongs to the CobB CobQ family
G0028_RS16185	COG0280	phosphate acetyltransferase
G0028_RS16230	COG0740	serine-type endopeptidase activity
G0028_RS16240	COG4774	siderophore transport
G0028_RS16255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G0028_RS16260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G0028_RS16265	COG2813	Specifically methylates the guanine in position
G0028_RS16265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G0028_RS16290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G0028_RS16330	COG3878	Protein conserved in bacteria
G0028_RS16335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G0028_RS16375	COG0788	formyltetrahydrofolate deformylase activity
G0028_RS16400	COG4651	solute:proton antiporter activity
G0028_RS16400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G0028_RS16430	COG0210	DNA helicase
G0028_RS16440	COG1929	Belongs to the glycerate kinase type-1 family
G0028_RS16485	COG2900	Belongs to the SlyX family
G0028_RS16490	COG0488	(ABC) transporter
G0028_RS16510	COG0830	nickel cation binding
G0028_RS16525	COG0804	urea catabolic process
G0028_RS16545	COG0829	nickel cation binding
G0028_RS16560	COG1560	Kdo2-lipid A biosynthetic process
G0028_RS16625	COG0473	3-isopropylmalate dehydrogenase activity
G0028_RS16640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G0028_RS16655	COG0583	DNA-binding transcription factor activity
G0028_RS16670	COG0494	nUDIX hydrolase
G0028_RS16690	COG1960	acyl-CoA dehydrogenase activity
G0028_RS16710	COG2801	Transposase and inactivated derivatives
G0028_RS16730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G0028_RS16760	COG0446	pyridine nucleotide-disulphide oxidoreductase
G0028_RS16765	COG3384	dioxygenase
G0028_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
G0028_RS16785	COG4638	Rieske (2fe-2S)
G0028_RS16790	COG0583	DNA-binding transcription factor activity
G0028_RS16815	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G0028_RS16820	COG3971	2-oxopent-4-enoate hydratase activity
G0028_RS16830	COG0546	phosphoglycolate phosphatase activity
G0028_RS16835	COG0564	pseudouridine synthase activity
G0028_RS16845	COG1530	ribonuclease E activity
G0028_RS16850	COG0318	PFAM AMP-dependent synthetase and ligase
G0028_RS16905	COG1983	PspC domain protein
G0028_RS16910	COG0617	tRNA 3'-terminal CCA addition
G0028_RS16910	COG0517	IMP dehydrogenase activity
G0028_RS16910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G0028_RS16935	COG0751	glycine-tRNA ligase activity
G0028_RS16965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G0028_RS17000	COG2226	methyltransferase
G0028_RS17015	COG0628	permease
G0028_RS17020	COG2032	superoxide dismutase activity
G0028_RS17025	COG1289	transmembrane transporter activity
G0028_RS17030	COG2814	Major facilitator Superfamily
G0028_RS17060	COG0277	FAD linked oxidase domain protein
G0028_RS17065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G0028_RS17100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G0028_RS17105	COG5380	lipid catabolic process
G0028_RS17115	COG0335	large ribosomal subunit rRNA binding
G0028_RS17125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G0028_RS17130	COG0228	four-way junction DNA binding
G0028_RS17185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G0028_RS17190	COG0194	GDP metabolic process
G0028_RS17195	COG1758	RNA polymerase activity
G0028_RS17200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G0028_RS17225	COG3307	-O-antigen
G0028_RS17245	COG2161	toxin-antitoxin pair type II binding
G0028_RS17345	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G0028_RS17350	COG1704	LemA family
G0028_RS17355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G0028_RS17365	COG0195	Participates in both transcription termination and antitermination
G0028_RS17370	COG0779	Required for maturation of 30S ribosomal subunits
G0028_RS17420	COG0237	dephospho-CoA kinase activity
G0028_RS17430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G0028_RS17435	COG3123	guanosine phosphorylase activity
G0028_RS17440	COG0497	DNA recombination
G0028_RS17470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G0028_RS17475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G0028_RS17490	COG0318	PFAM AMP-dependent synthetase and ligase
G0028_RS17500	COG0477	Major facilitator Superfamily
G0028_RS17505	COG2860	membrane
G0028_RS17520	COG2226	methyltransferase
G0028_RS17525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G0028_RS17530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G0028_RS17535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G0028_RS17550	COG0275	rRNA processing
G0028_RS17560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G0028_RS17565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G0028_RS17575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G0028_RS17605	COG0488	(ABC) transporter
G0028_RS17615	COG4221	oxidoreductase activity
G0028_RS17635	COG0427	acetyl-CoA hydrolase
G0028_RS17680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G0028_RS17710	COG0697	spore germination
G0028_RS17715	COG2329	Antibiotic biosynthesis monooxygenase
G0028_RS17730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G0028_RS17775	COG3158	transport of potassium into the cell
G0028_RS17785	COG0582	viral genome integration into host DNA
G0028_RS17830	COG3293	Transposase
G0028_RS17860	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G0028_RS17870	COG1335	isochorismatase
G0028_RS17875	COG0583	DNA-binding transcription factor activity
G0028_RS17895	COG0629	single-stranded DNA binding
G0028_RS17900	COG2814	Major facilitator Superfamily
G0028_RS17910	COG0352	thiamine-phosphate diphosphorylase activity
G0028_RS17910	COG0351	phosphomethylpyrimidine kinase
G0028_RS17910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G0028_RS17920	COG3136	membrane protein required for alginate biosynthesis
G0028_RS17930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G0028_RS17960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G0028_RS17970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G0028_RS17975	COG3162	membrane
G0028_RS17980	COG2205	protein histidine kinase activity
G0028_RS17980	COG0784	Response regulator, receiver
G0028_RS17990	COG0596	Alpha beta hydrolase
G0028_RS18015	COG0708	Exodeoxyribonuclease III
G0028_RS18020	COG1393	Belongs to the ArsC family
G0028_RS18040	COG1902	pentaerythritol trinitrate reductase activity
G0028_RS18060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G0028_RS18095	COG0426	domain, Protein
G0028_RS18095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G0028_RS18100	COG2119	membrane
G0028_RS18130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G0028_RS18135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G0028_RS18145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G0028_RS18155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G0028_RS18170	COG0189	ligase activity
G0028_RS18180	COG1715	Restriction endonuclease
G0028_RS18185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G0028_RS18185	COG0519	Catalyzes the synthesis of GMP from XMP
G0028_RS18200	COG4628	conserved protein (DUF2132)
G0028_RS18215	COG1104	cysteine desulfurase activity
G0028_RS18290	COG1752	Esterase of the alpha-beta hydrolase superfamily
G0028_RS18300	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G0028_RS18360	COG0271	Belongs to the BolA IbaG family
G0028_RS18370	COG1192	Involved in chromosome partitioning
G0028_RS18385	COG0586	Pfam SNARE associated Golgi protein
G0028_RS18390	COG2259	Doxx family
G0028_RS18415	COG1479	Protein of unknown function DUF262
G0028_RS18505	COG3293	Transposase
G0028_RS18565	COG0625	glutathione transferase activity
G0028_RS18585	COG3733	amine oxidase
G0028_RS18595	COG1012	belongs to the aldehyde dehydrogenase family
G0028_RS18625	COG1683	Conserved Protein
G0028_RS18630	COG0385	Bile acid
G0028_RS18635	COG1335	isochorismatase
G0028_RS18640	COG2814	Major facilitator Superfamily
G0028_RS18645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G0028_RS18675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G0028_RS18680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G0028_RS18685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G0028_RS18690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G0028_RS18695	COG1116	anion transmembrane transporter activity
G0028_RS18700	COG1309	transcriptional regulator
G0028_RS18705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G0028_RS18740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G0028_RS18745	COG2233	PERMEase
G0028_RS18755	COG0196	riboflavin kinase activity
G0028_RS18760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G0028_RS18770	COG1047	Peptidyl-prolyl cis-trans
G0028_RS18785	COG2814	Major facilitator Superfamily
G0028_RS18815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G0028_RS18820	COG0657	acetylesterase activity
G0028_RS18860	COG2951	lytic endotransglycosylase activity
G0028_RS18865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G0028_RS18885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G0028_RS18895	COG2388	GCN5-related N-acetyl-transferase
G0028_RS18900	COG2388	GCN5-related N-acetyl-transferase
G0028_RS18905	COG2814	Major facilitator Superfamily
G0028_RS18910	COG0861	Integral membrane protein TerC family
G0028_RS18925	COG0754	glutathionylspermidine amidase activity
G0028_RS18935	COG0402	S-adenosylhomocysteine deaminase activity
G0028_RS18940	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G0028_RS19025	COG0582	viral genome integration into host DNA
G0028_RS19035	COG0706	membrane insertase activity
G0028_RS19040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G0028_RS19045	COG0594	ribonuclease P activity
G0028_RS19055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G0028_RS19060	COG3550	peptidyl-serine autophosphorylation
G0028_RS19075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G0028_RS19085	COG1136	(ABC) transporter
G0028_RS19105	COG2351	hydroxyisourate hydrolase activity
G0028_RS19120	COG3046	protein related to deoxyribodipyrimidine photolyase
G0028_RS19125	COG2816	NAD+ diphosphatase activity
G0028_RS19150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G0028_RS19165	COG0642	Histidine kinase
G0028_RS19260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G0028_RS19265	COG0582	viral genome integration into host DNA
G0028_RS19350	COG4372	Transposase
G0028_RS19400	COG1309	transcriptional regulator
G0028_RS19405	COG2130	NADP-dependent
G0028_RS19430	COG4115	mRNA cleavage
G0028_RS19435	COG2161	toxin-antitoxin pair type II binding
G0028_RS19475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G0028_RS19480	COG0022	dehydrogenase e1 component
G0028_RS19485	COG0508	dehydrogenase complex catalyzes the overall conversion of
G0028_RS19490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G0028_RS19545	COG0642	Histidine kinase
G0028_RS19565	COG2801	Transposase and inactivated derivatives
G0028_RS19605	COG2801	Transposase and inactivated derivatives
G0028_RS19675	COG1192	Involved in chromosome partitioning
G0028_RS19680	COG1475	DNA binding
G0028_RS19740	COG1373	ATPase (AAA superfamily
G0028_RS19815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G0028_RS19870	COG2217	Heavy metal translocating P-type atpase
G0028_RS19875	COG3174	membrane
G0028_RS19880	COG2205	protein histidine kinase activity
G0028_RS19895	COG2132	Multicopper oxidase
G0028_RS19965	COG1373	ATPase (AAA superfamily
G0028_RS20035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G0028_RS20045	COG2194	sulfuric ester hydrolase activity
G0028_RS20125	COG1063	alcohol dehydrogenase
G0028_RS20140	COG4716	Myosin-crossreactive antigen
G0028_RS20225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G0028_RS20230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G0028_RS20250	COG2369	cell adhesion
G0028_RS20255	COG0582	viral genome integration into host DNA
G0028_RS20260	COG0789	Transcriptional regulator
G0028_RS20270	COG1230	cation diffusion facilitator family transporter
G0028_RS20305	COG1683	Conserved Protein
G0028_RS20375	COG4974	Belongs to the 'phage' integrase family
G0028_RS20405	COG3173	Aminoglycoside phosphotransferase
G0028_RS20495	COG2801	Transposase and inactivated derivatives
G0028_RS20535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G0028_RS20545	COG0488	(ABC) transporter
G0028_RS20550	COG3173	Aminoglycoside phosphotransferase
G0028_RS20585	COG0488	(ABC) transporter
G0028_RS20615	COG0488	(ABC) transporter
G0028_RS20785	COG2076	Multidrug Resistance protein
G0028_RS20855	COG4716	Myosin-crossreactive antigen
G0028_RS20895	COG3077	Addiction module antitoxin, RelB DinJ family
G0028_RS20915	COG4115	mRNA cleavage
G0028_RS20940	COG0488	(ABC) transporter
G0028_RS20965	COG4221	oxidoreductase activity