locus-tag	class	description
DKE41_RS00010	COG0592	DNA-directed DNA polymerase activity
DKE41_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKE41_RS00105	COG0625	glutathione transferase activity
DKE41_RS00155	COG2233	PERMEase
DKE41_RS00205	COG2814	Major facilitator Superfamily
DKE41_RS00210	COG0656	L-ascorbic acid biosynthetic process
DKE41_RS00240	COG2818	Glycosylase
DKE41_RS00255	COG1194	a g-specific adenine glycosylase
DKE41_RS00275	COG2983	Belongs to the UPF0260 family
DKE41_RS00280	COG2133	pyrroloquinoline quinone binding
DKE41_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE41_RS00320	COG0385	Bile acid
DKE41_RS00325	COG1683	Conserved Protein
DKE41_RS00365	COG0523	cobalamin synthesis protein
DKE41_RS00375	COG2188	Transcriptional regulator
DKE41_RS00425	COG1280	lysine exporter protein (LysE YggA)
DKE41_RS00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKE41_RS00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DKE41_RS00525	COG1910	domain protein
DKE41_RS00560	COG0436	Aminotransferase
DKE41_RS00565	COG2733	membrane
DKE41_RS00615	COG3150	esterase
DKE41_RS00625	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKE41_RS00640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE41_RS00650	COG2233	PERMEase
DKE41_RS00655	COG2351	hydroxyisourate hydrolase activity
DKE41_RS00785	COG4942	peptidase
DKE41_RS00805	COG2119	membrane
DKE41_RS00815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE41_RS00815	COG0426	domain, Protein
DKE41_RS00860	COG1902	pentaerythritol trinitrate reductase activity
DKE41_RS00885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE41_RS00890	COG1335	isochorismatase
DKE41_RS00895	COG1522	sequence-specific DNA binding
DKE41_RS00925	COG3162	membrane
DKE41_RS00930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE41_RS00960	COG1309	transcriptional regulator
DKE41_RS00980	COG0300	oxidoreductase activity
DKE41_RS01055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKE41_RS01060	COG1012	belongs to the aldehyde dehydrogenase family
DKE41_RS01070	COG1335	isochorismatase
DKE41_RS01110	COG0583	DNA-binding transcription factor activity
DKE41_RS01125	COG1309	transcriptional regulator
DKE41_RS01145	COG0667	Aldo Keto reductase
DKE41_RS01190	COG1733	regulation of RNA biosynthetic process
DKE41_RS01240	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DKE41_RS01390	COG2329	Antibiotic biosynthesis monooxygenase
DKE41_RS01425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE41_RS01485	COG4221	oxidoreductase activity
DKE41_RS01705	COG1704	LemA family
DKE41_RS01725	COG3307	-O-antigen
DKE41_RS01730	COG3307	-O-antigen
DKE41_RS01780	COG0194	GDP metabolic process
DKE41_RS01845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE41_RS01855	COG0335	large ribosomal subunit rRNA binding
DKE41_RS01870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DKE41_RS01895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKE41_RS01910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE41_RS01975	COG0833	amino acid
DKE41_RS01985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE41_RS01995	COG1012	belongs to the aldehyde dehydrogenase family
DKE41_RS02040	COG1794	racemase activity, acting on amino acids and derivatives
DKE41_RS02045	COG0583	DNA-binding transcription factor activity
DKE41_RS02070	COG0752	glycyl-tRNA synthetase alpha subunit
DKE41_RS02100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DKE41_RS02100	COG0617	tRNA 3'-terminal CCA addition
DKE41_RS02100	COG0517	IMP dehydrogenase activity
DKE41_RS02160	COG1127	ABC transporter
DKE41_RS02165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE41_RS02175	COG2854	intermembrane phospholipid transfer
DKE41_RS02245	COG1959	2 iron, 2 sulfur cluster binding
DKE41_RS02250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE41_RS02250	COG1017	nitric oxide dioxygenase activity
DKE41_RS02280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE41_RS02285	COG0088	Forms part of the polypeptide exit tunnel
DKE41_RS02420	COG1960	acyl-CoA dehydrogenase activity
DKE41_RS02425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKE41_RS02455	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE41_RS02515	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE41_RS02555	COG1702	phosphate starvation-inducible protein PhoH
DKE41_RS02565	COG1196	nuclear chromosome segregation
DKE41_RS02565	COG0741	lytic transglycosylase activity
DKE41_RS02565	COG0739	heme binding
DKE41_RS02595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DKE41_RS02600	COG1183	phosphatidylcholine synthase activity
DKE41_RS02650	COG1309	transcriptional regulator
DKE41_RS02720	COG2969	positive regulation of protein catabolic process
DKE41_RS02725	COG0625	glutathione transferase activity
DKE41_RS02730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE41_RS02740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKE41_RS02745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE41_RS02750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE41_RS02790	COG1408	metallophosphoesterase
DKE41_RS02870	COG1607	acyl-coa hydrolase
DKE41_RS02905	COG2350	Protein conserved in bacteria
DKE41_RS02920	COG3781	membrane
DKE41_RS02930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE41_RS02935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE41_RS02945	COG1862	Preprotein translocase
DKE41_RS03035	COG0726	polysaccharide deacetylase
DKE41_RS03045	COG0438	transferase activity, transferring glycosyl groups
DKE41_RS03160	COG2205	protein histidine kinase activity
DKE41_RS03165	COG0745	RESPONSE REGULATOR receiver
DKE41_RS03285	COG0477	Major facilitator Superfamily
DKE41_RS03290	COG1272	protein, Hemolysin III
DKE41_RS03300	COG2153	protein acetylation
DKE41_RS03320	COG0183	Belongs to the thiolase family
DKE41_RS03325	COG2207	Transcriptional regulator
DKE41_RS03345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE41_RS03375	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE41_RS03375	COG2885	chlorophyll binding
DKE41_RS03385	COG0833	amino acid
DKE41_RS03425	COG2094	Belongs to the DNA glycosylase MPG family
DKE41_RS03435	COG1902	pentaerythritol trinitrate reductase activity
DKE41_RS03470	COG3189	MarR family transcriptional regulator
DKE41_RS03475	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE41_RS03545	COG5510	response to toxic substance
DKE41_RS03555	COG2832	Protein of unknown function (DUF454)
DKE41_RS03640	COG1115	amino acid carrier protein
DKE41_RS03650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKE41_RS03690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE41_RS03700	COG1792	Involved in formation and maintenance of cell shape
DKE41_RS03705	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DKE41_RS03710	COG0424	maF-like protein
DKE41_RS03715	COG1530	ribonuclease E activity
DKE41_RS03770	COG2207	Transcriptional regulator
DKE41_RS03855	COG0745	RESPONSE REGULATOR receiver
DKE41_RS03870	COG0004	ammonium transporteR
DKE41_RS03895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DKE41_RS03900	COG0525	valine-tRNA ligase activity
DKE41_RS03930	COG0393	Putative heavy-metal-binding
DKE41_RS03935	COG0393	Putative heavy-metal-binding
DKE41_RS04000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE41_RS04015	COG0531	amino acid
DKE41_RS04035	COG2921	Belongs to the UPF0250 family
DKE41_RS04075	COG2009	succinate dehydrogenase
DKE41_RS04080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DKE41_RS04090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE41_RS04250	COG0589	response to stress
DKE41_RS04260	COG0251	oxidation-reduction process
DKE41_RS04265	COG1309	transcriptional regulator
DKE41_RS04280	COG0505	Belongs to the CarA family
DKE41_RS04310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE41_RS04390	COG1597	lipid kinase activity
DKE41_RS04500	COG0789	Transcriptional regulator
DKE41_RS04525	COG2801	Transposase and inactivated derivatives
DKE41_RS04530	COG2801	Transposase and inactivated derivatives
DKE41_RS04570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE41_RS04605	COG1113	amino acid transport
DKE41_RS04630	COG1280	lysine exporter protein (LysE YggA)
DKE41_RS04665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE41_RS04700	COG1136	(ABC) transporter
DKE41_RS04715	COG0616	signal peptide processing
DKE41_RS04715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DKE41_RS04720	COG0596	Alpha beta hydrolase
DKE41_RS04725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE41_RS04790	COG0823	Involved in the tonB-independent uptake of proteins
DKE41_RS04810	COG0824	Thioesterase
DKE41_RS04840	COG0047	phosphoribosylformylglycinamidine synthase activity
DKE41_RS04840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DKE41_RS04880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DKE41_RS04895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE41_RS04910	COG4625	pathogenesis
DKE41_RS04920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKE41_RS04930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKE41_RS04940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DKE41_RS04950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DKE41_RS05020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DKE41_RS05060	COG0436	Aminotransferase
DKE41_RS05080	COG0556	nucleotide-excision repair
DKE41_RS05135	COG2070	2-Nitropropane dioxygenase
DKE41_RS05160	COG1215	transferase activity, transferring glycosyl groups
DKE41_RS05185	COG1252	NADH dehydrogenase
DKE41_RS05190	COG1686	Belongs to the peptidase S11 family
DKE41_RS05205	COG1187	pseudouridine synthase activity
DKE41_RS05265	COG0352	thiamine-phosphate diphosphorylase activity
DKE41_RS05320	COG0076	glutamate decarboxylase activity
DKE41_RS05335	COG3961	Belongs to the TPP enzyme family
DKE41_RS05345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKE41_RS05350	COG0573	inorganic phosphate transmembrane transporter activity
DKE41_RS05365	COG0616	signal peptide processing
DKE41_RS05400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE41_RS05405	COG1686	Belongs to the peptidase S11 family
DKE41_RS05435	COG1067	ATP-dependent peptidase activity
DKE41_RS05480	COG1966	Carbon starvation protein
DKE41_RS05555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DKE41_RS05570	COG2964	Protein conserved in bacteria
DKE41_RS05580	COG1741	Belongs to the pirin family
DKE41_RS05610	COG4604	ABC transporter, ATP-binding protein
DKE41_RS05635	COG1021	2,3-dihydroxybenzoate-AMP ligase
DKE41_RS05660	COG1132	(ABC) transporter
DKE41_RS05665	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DKE41_RS05695	COG3739	integral membrane protein
DKE41_RS05715	COG0302	gtp cyclohydrolase
DKE41_RS05725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DKE41_RS05750	COG0512	Glutamine amidotransferase of anthranilate synthase
DKE41_RS05765	COG0174	glutamine synthetase
DKE41_RS05810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE41_RS05815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE41_RS05840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKE41_RS05845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE41_RS05850	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DKE41_RS05870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE41_RS05945	COG0772	Belongs to the SEDS family
DKE41_RS05960	COG0842	Transport permease protein
DKE41_RS06030	COG4160	amino acid transport
DKE41_RS06045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE41_RS06050	COG0826	peptidase U32
DKE41_RS06060	COG0384	phenazine biosynthesis protein PhzF
DKE41_RS06080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DKE41_RS06125	COG3139	Protein of unknown function (DUF1315)
DKE41_RS06130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKE41_RS06140	COG1301	dicarboxylic acid transport
DKE41_RS06165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DKE41_RS06195	COG1690	Belongs to the RtcB family
DKE41_RS06250	COG1278	Cold shock
DKE41_RS06255	COG0513	Belongs to the DEAD box helicase family
DKE41_RS06295	COG1286	toxin biosynthetic process
DKE41_RS06325	COG1610	YqeY-like protein
DKE41_RS06355	COG0515	serine threonine protein kinase
DKE41_RS06355	COG2815	serine threonine protein kinase
DKE41_RS06395	COG3243	poly(R)-hydroxyalkanoic acid synthase
DKE41_RS06440	COG0583	DNA-binding transcription factor activity
DKE41_RS06450	COG2995	paraquat-inducible protein a
DKE41_RS06455	COG3008	intermembrane lipid transfer
DKE41_RS06455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DKE41_RS06465	COG2351	hydroxyisourate hydrolase activity
DKE41_RS06520	COG0642	Histidine kinase
DKE41_RS06525	COG0745	RESPONSE REGULATOR receiver
DKE41_RS06540	COG1794	racemase activity, acting on amino acids and derivatives
DKE41_RS06580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE41_RS06590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE41_RS06600	COG0151	Belongs to the GarS family
DKE41_RS06660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE41_RS06665	COG0305	Participates in initiation and elongation during chromosome replication
DKE41_RS06700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE41_RS06740	COG3658	cytochrome
DKE41_RS06780	COG2890	protein-(glutamine-N5) methyltransferase activity
DKE41_RS06810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE41_RS06880	COG0729	surface antigen
DKE41_RS06975	COG1187	pseudouridine synthase activity
DKE41_RS07030	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE41_RS07050	COG4302	ethanolamine ammonia-lyase activity
DKE41_RS07060	COG0531	amino acid
DKE41_RS07080	COG1454	alcohol dehydrogenase
DKE41_RS07095	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DKE41_RS07115	COG0308	aminopeptidase N
DKE41_RS07265	COG0583	DNA-binding transcription factor activity
DKE41_RS07310	COG0589	response to stress
DKE41_RS07335	COG1522	sequence-specific DNA binding
DKE41_RS07350	COG0583	DNA-binding transcription factor activity
DKE41_RS07375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DKE41_RS07445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKE41_RS07515	COG0511	ligase activity, forming carbon-carbon bonds
DKE41_RS07605	COG2146	nitrite reductase [NAD(P)H] activity
DKE41_RS07605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE41_RS07625	COG0243	molybdopterin cofactor binding
DKE41_RS07635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKE41_RS07650	COG0521	Mo-molybdopterin cofactor biosynthetic process
DKE41_RS07650	COG0315	cyclic pyranopterin monophosphate synthase activity
DKE41_RS07665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE41_RS07695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE41_RS07710	COG0596	Alpha beta hydrolase
DKE41_RS07790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DKE41_RS07795	COG0575	Belongs to the CDS family
DKE41_RS07845	COG2137	regulation of response to DNA damage stimulus
DKE41_RS07855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DKE41_RS07875	COG1522	sequence-specific DNA binding
DKE41_RS07885	COG1113	amino acid transport
DKE41_RS07940	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DKE41_RS07940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE41_RS07940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE41_RS07945	COG1105	Belongs to the carbohydrate kinase PfkB family
DKE41_RS07970	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DKE41_RS07995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE41_RS08000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE41_RS08005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DKE41_RS08005	COG0517	IMP dehydrogenase activity
DKE41_RS08055	COG4890	Cyd operon protein YbgT
DKE41_RS08060	COG1294	oxidase, subunit
DKE41_RS08220	COG2323	membrane
DKE41_RS08235	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE41_RS08250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE41_RS08255	COG0183	Belongs to the thiolase family
DKE41_RS08270	COG2271	Major facilitator Superfamily
DKE41_RS08275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE41_RS08285	COG3485	protocatechuate 3,4-dioxygenase
DKE41_RS08315	COG2391	methyltransferase activity
DKE41_RS08330	COG1414	Transcriptional regulator
DKE41_RS08375	COG0154	amidase activity
DKE41_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS08415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE41_RS08465	COG4829	muconolactone delta-isomerase
DKE41_RS08485	COG3971	2-oxopent-4-enoate hydratase activity
DKE41_RS08510	COG0583	DNA-binding transcription factor activity
DKE41_RS08520	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE41_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS08535	COG3384	dioxygenase
DKE41_RS08585	COG1309	transcriptional regulator
DKE41_RS08655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKE41_RS08660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DKE41_RS08730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE41_RS08735	COG1120	ATPase activity
DKE41_RS08750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE41_RS08960	COG3539	Fimbrial protein
DKE41_RS08985	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE41_RS09030	COG0745	RESPONSE REGULATOR receiver
DKE41_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS09105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DKE41_RS09110	COG4149	molybdate abc transporter
DKE41_RS09115	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE41_RS09125	COG4638	Rieske (2fe-2S)
DKE41_RS09130	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE41_RS09135	COG0543	2 iron, 2 sulfur cluster binding
DKE41_RS09135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE41_RS09155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE41_RS09185	COG2207	Transcriptional regulator
DKE41_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS09195	COG2610	gluconate transmembrane transporter activity
DKE41_RS09250	COG0583	DNA-binding transcription factor activity
DKE41_RS09270	COG0183	Belongs to the thiolase family
DKE41_RS09275	COG0583	DNA-binding transcription factor activity
DKE41_RS09295	COG1027	Aspartate ammonia-lyase
DKE41_RS09330	COG0730	response to heat
DKE41_RS09355	COG1063	alcohol dehydrogenase
DKE41_RS09365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE41_RS09370	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE41_RS09375	COG0022	dehydrogenase e1 component
DKE41_RS09380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE41_RS09385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE41_RS09400	COG3706	GGDEF domain
DKE41_RS09465	COG0583	DNA-binding transcription factor activity
DKE41_RS09540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE41_RS09545	COG4773	Receptor
DKE41_RS09570	COG0730	response to heat
DKE41_RS09575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE41_RS09645	COG1960	acyl-CoA dehydrogenase activity
DKE41_RS09650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKE41_RS09655	COG2207	Transcriptional regulator
DKE41_RS09665	COG0776	regulation of translation
DKE41_RS09690	COG0822	iron-sulfur transferase activity
DKE41_RS09695	COG0316	Belongs to the HesB IscA family
DKE41_RS09790	COG0601	transmembrane transport
DKE41_RS09850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DKE41_RS09945	COG0084	hydrolase, TatD family'
DKE41_RS09980	COG0811	peptide transport
DKE41_RS09990	COG1192	Involved in chromosome partitioning
DKE41_RS10000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DKE41_RS10015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKE41_RS10055	COG0640	Transcriptional regulator
DKE41_RS10095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKE41_RS10100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE41_RS10115	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE41_RS10130	COG3698	Phosphodiester glycosidase
DKE41_RS10140	COG2353	YceI-like domain
DKE41_RS10150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DKE41_RS10195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DKE41_RS10195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DKE41_RS10220	COG3539	Fimbrial protein
DKE41_RS10245	COG0583	DNA-binding transcription factor activity
DKE41_RS10260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DKE41_RS10300	COG1522	sequence-specific DNA binding
DKE41_RS10310	COG1126	abc transporter atp-binding protein
DKE41_RS10320	COG0765	amino acid transport
DKE41_RS10350	COG1464	Belongs to the NlpA lipoprotein family
DKE41_RS10360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE41_RS10485	COG3634	alkyl hydroperoxide reductase activity
DKE41_RS10505	COG0431	NADPH-dependent FMN reductase
DKE41_RS10575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE41_RS10580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DKE41_RS10585	COG4521	taurine ABC transporter
DKE41_RS10615	COG1271	oxidase subunit
DKE41_RS10620	COG1294	oxidase, subunit
DKE41_RS10650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DKE41_RS10705	COG1346	cytolysis
DKE41_RS10715	COG0583	DNA-binding transcription factor activity
DKE41_RS10725	COG0625	glutathione transferase activity
DKE41_RS10730	COG0583	DNA-binding transcription factor activity
DKE41_RS10795	COG0765	amino acid transport
DKE41_RS10840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE41_RS10860	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS10920	COG2814	Major facilitator Superfamily
DKE41_RS10940	COG1309	transcriptional regulator
DKE41_RS10945	COG1960	acyl-CoA dehydrogenase activity
DKE41_RS10955	COG1024	Enoyl-CoA hydratase
DKE41_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS11035	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKE41_RS11040	COG0183	Belongs to the thiolase family
DKE41_RS11060	COG1024	Enoyl-CoA hydratase
DKE41_RS11070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DKE41_RS11085	COG1280	lysine exporter protein (LysE YggA)
DKE41_RS11100	COG1414	Transcriptional regulator
DKE41_RS11150	COG3327	negative regulation of DNA-templated transcription, initiation
DKE41_RS11175	COG1024	Enoyl-CoA hydratase
DKE41_RS11185	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE41_RS11195	COG3460	Phenylacetate-CoA oxygenase
DKE41_RS11200	COG3396	Phenylacetate-CoA oxygenase
DKE41_RS11245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE41_RS11265	COG0590	tRNA wobble adenosine to inosine editing
DKE41_RS11460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE41_RS11485	COG1733	regulation of RNA biosynthetic process
DKE41_RS11490	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE41_RS11510	COG1063	alcohol dehydrogenase
DKE41_RS11540	COG2801	Transposase and inactivated derivatives
DKE41_RS11565	COG0038	chloride channel
DKE41_RS11595	COG0583	DNA-binding transcription factor activity
DKE41_RS11605	COG1595	DNA-templated transcription, initiation
DKE41_RS11615	COG3220	belongs to the UPF0276 family
DKE41_RS11680	COG1733	regulation of RNA biosynthetic process
DKE41_RS11735	COG3038	cytochrome b561
DKE41_RS11745	COG1733	regulation of RNA biosynthetic process
DKE41_RS11760	COG1469	GTP cyclohydrolase I activity
DKE41_RS11765	COG4451	ribulose bisphosphate carboxylase, small
DKE41_RS11765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE41_RS11780	COG1278	Cold shock
DKE41_RS11815	COG0531	amino acid
DKE41_RS11820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE41_RS11835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKE41_RS11850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE41_RS11860	COG4122	O-methyltransferase activity
DKE41_RS11895	COG1137	ATPase activity
DKE41_RS11900	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE41_RS11910	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKE41_RS11975	COG0668	transmembrane transport
DKE41_RS12050	COG2226	methyltransferase
DKE41_RS12070	COG1278	Cold shock
DKE41_RS12075	COG1560	Kdo2-lipid A biosynthetic process
DKE41_RS12115	COG1570	exodeoxyribonuclease VII activity
DKE41_RS12180	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE41_RS12185	COG0633	Ferredoxin
DKE41_RS12185	COG0543	2 iron, 2 sulfur cluster binding
DKE41_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS12220	COG1643	Atp-dependent helicase
DKE41_RS12375	COG2885	chlorophyll binding
DKE41_RS12410	COG0542	response to heat
DKE41_RS12425	COG1765	OsmC-like protein
DKE41_RS12440	COG0667	Aldo Keto reductase
DKE41_RS12470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DKE41_RS12480	COG0582	viral genome integration into host DNA
DKE41_RS12590	COG1598	PFAM Uncharacterised protein family UPF0150
DKE41_RS12870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DKE41_RS12880	COG3038	cytochrome b561
DKE41_RS12890	COG2252	PERMEase
DKE41_RS12900	COG1741	Belongs to the pirin family
DKE41_RS12905	COG1309	transcriptional regulator
DKE41_RS12915	COG0300	oxidoreductase activity
DKE41_RS12925	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DKE41_RS12955	COG1944	ATP diphosphatase activity
DKE41_RS13010	COG2814	Major facilitator Superfamily
DKE41_RS13020	COG1012	belongs to the aldehyde dehydrogenase family
DKE41_RS13090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DKE41_RS13105	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DKE41_RS13140	COG1677	Flagellar hook-basal body complex protein FliE
DKE41_RS13160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DKE41_RS13170	COG4786	Flagellar basal body rod
DKE41_RS13195	COG1987	bacterial-type flagellum assembly
DKE41_RS13240	COG1113	amino acid transport
DKE41_RS13385	COG0583	DNA-binding transcription factor activity
DKE41_RS13435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE41_RS13465	COG4172	Belongs to the ABC transporter superfamily
DKE41_RS13535	COG1279	arginine transmembrane transporter activity
DKE41_RS13605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DKE41_RS13620	COG3384	dioxygenase
DKE41_RS13635	COG2878	Part of a membrane complex involved in electron transport
DKE41_RS13640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKE41_RS13650	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DKE41_RS13660	COG0714	Associated with various cellular activities
DKE41_RS13750	COG3015	lipoprotein NlpE involved in copper resistance
DKE41_RS13820	COG1773	rubredoxin
DKE41_RS13915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE41_RS13935	COG0306	phosphate transporter
DKE41_RS13960	COG2223	nitrite transmembrane transporter activity
DKE41_RS13965	COG2207	Transcriptional regulator
DKE41_RS13975	COG0242	peptide deformylase activity
DKE41_RS13990	COG0028	Belongs to the TPP enzyme family
DKE41_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS14055	COG1414	Transcriptional regulator
DKE41_RS14070	COG1024	Enoyl-CoA hydratase
DKE41_RS14080	COG1215	transferase activity, transferring glycosyl groups
DKE41_RS14115	COG1607	acyl-coa hydrolase
DKE41_RS14265	COG2814	Major facilitator Superfamily
DKE41_RS14275	COG2050	protein possibly involved in aromatic compounds catabolism
DKE41_RS14290	COG1090	epimerase
DKE41_RS14340	COG0735	belongs to the Fur family
DKE41_RS14345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE41_RS14370	COG0121	glutamine amidotransferase
DKE41_RS14400	COG2885	chlorophyll binding
DKE41_RS14420	COG2894	cell division
DKE41_RS14445	COG0492	ferredoxin-NADP+ reductase activity
DKE41_RS14450	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DKE41_RS14460	COG0456	acetyltransferase
DKE41_RS14505	COG1981	membrane
DKE41_RS14545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE41_RS14630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE41_RS14670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE41_RS14670	COG0351	phosphomethylpyrimidine kinase
DKE41_RS14670	COG0352	thiamine-phosphate diphosphorylase activity
DKE41_RS14700	COG1399	metal-binding, possibly nucleic acid-binding protein
DKE41_RS14705	COG3101	peptidyl-lysine hydroxylation
DKE41_RS14710	COG0009	L-threonylcarbamoyladenylate synthase
DKE41_RS14715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DKE41_RS14720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE41_RS14735	COG4106	trans-aconitate 2-methyltransferase activity
DKE41_RS14820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE41_RS14870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE41_RS14935	COG0668	transmembrane transport
DKE41_RS14980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKE41_RS15010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DKE41_RS15050	COG0745	RESPONSE REGULATOR receiver
DKE41_RS15065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKE41_RS15110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE41_RS15130	COG0583	DNA-binding transcription factor activity
DKE41_RS15205	COG1309	transcriptional regulator
DKE41_RS15215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DKE41_RS15220	COG2814	Major facilitator Superfamily
DKE41_RS15235	COG1063	alcohol dehydrogenase
DKE41_RS15270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKE41_RS15275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE41_RS15305	COG0561	phosphatase activity
DKE41_RS15310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE41_RS15320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE41_RS15335	COG1214	PFAM Peptidase M22, glycoprotease
DKE41_RS15395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE41_RS15400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE41_RS15465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE41_RS15475	COG1846	Transcriptional regulator
DKE41_RS15480	COG1764	response to oxidative stress
DKE41_RS15530	COG0248	Ppx GppA phosphatase
DKE41_RS15580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE41_RS15595	COG1238	metal cluster binding
DKE41_RS15600	COG0625	glutathione transferase activity
DKE41_RS15625	COG3028	Belongs to the UPF0307 family
DKE41_RS15630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE41_RS15660	COG1555	photosystem II stabilization
DKE41_RS15770	COG2814	Major facilitator Superfamily
DKE41_RS15805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE41_RS15865	COG1309	transcriptional regulator
DKE41_RS15875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKE41_RS15880	COG0440	acetolactate synthase activity
DKE41_RS15885	COG0028	Belongs to the TPP enzyme family
DKE41_RS15935	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DKE41_RS15950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE41_RS15975	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS16015	COG2986	histidine ammonia-lyase
DKE41_RS16025	COG1216	Glycosyl transferase, family 2
DKE41_RS16040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE41_RS16120	COG0793	Belongs to the peptidase S41A family
DKE41_RS16145	COG1012	belongs to the aldehyde dehydrogenase family
DKE41_RS16150	COG3265	gluconokinase activity
DKE41_RS16185	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE41_RS16185	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE41_RS16235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE41_RS16235	COG2813	Specifically methylates the guanine in position
DKE41_RS16375	COG0583	DNA-binding transcription factor activity
DKE41_RS16395	COG0235	Class ii aldolase
DKE41_RS16410	COG1012	belongs to the aldehyde dehydrogenase family
DKE41_RS16440	COG1522	sequence-specific DNA binding
DKE41_RS16455	COG2207	Transcriptional regulator
DKE41_RS16475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE41_RS16570	COG0724	RNA recognition motif
DKE41_RS16575	COG0210	DNA helicase
DKE41_RS16600	COG1733	regulation of RNA biosynthetic process
DKE41_RS16605	COG0604	alcohol dehydrogenase
DKE41_RS16610	COG2900	Belongs to the SlyX family
DKE41_RS16625	COG1560	Kdo2-lipid A biosynthetic process
DKE41_RS16690	COG0473	3-isopropylmalate dehydrogenase activity
DKE41_RS16770	COG2378	regulation of single-species biofilm formation
DKE41_RS16805	COG0583	DNA-binding transcription factor activity
DKE41_RS16815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKE41_RS16880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE41_RS16885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE41_RS16900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE41_RS16910	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DKE41_RS16910	COG0644	oxidoreductase
DKE41_RS16925	COG4535	Mg2 and Co2 transporter CorC
DKE41_RS16965	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE41_RS16980	COG0789	Transcriptional regulator
DKE41_RS16985	COG0598	Magnesium transport protein CorA
DKE41_RS17000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DKE41_RS17015	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DKE41_RS17045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKE41_RS17085	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE41_RS17095	COG1863	multisubunit Na H antiporter MnhE subunit
DKE41_RS17100	COG2212	antiporter activity
DKE41_RS17110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE41_RS17180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE41_RS17195	COG0497	DNA recombination
DKE41_RS17205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DKE41_RS17245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE41_RS17350	COG2056	Na+-H+ antiporter family
DKE41_RS17455	COG0546	phosphoglycolate phosphatase activity
DKE41_RS17460	COG1716	ATPase activity
DKE41_RS17545	COG0697	spore germination
DKE41_RS17575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE41_RS17610	COG4974	Belongs to the 'phage' integrase family
DKE41_RS17625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE41_RS17700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKE41_RS17700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKE41_RS17745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE41_RS17765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DKE41_RS17790	COG0477	Major facilitator Superfamily
DKE41_RS17795	COG2860	membrane
DKE41_RS17800	COG3012	SEC-C Motif Domain Protein
DKE41_RS17815	COG2814	Major facilitator Superfamily
DKE41_RS17825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE41_RS17865	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE41_RS17945	COG0758	DNA mediated transformation
DKE41_RS17985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DKE41_RS17990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE41_RS18000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DKE41_RS18045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE41_RS18055	COG2837	iron assimilation
DKE41_RS18065	COG0281	malic enzyme
DKE41_RS18100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
DKE41_RS18110	COG4399	Belongs to the UPF0754 family
DKE41_RS18115	COG2259	Doxx family
DKE41_RS18120	COG0586	Pfam SNARE associated Golgi protein
DKE41_RS18145	COG0271	Belongs to the BolA IbaG family
DKE41_RS18190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE41_RS18190	COG3321	synthase
DKE41_RS18190	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DKE41_RS18190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKE41_RS18215	COG3916	Acyl-homoserine-lactone synthase
DKE41_RS18230	COG1024	Enoyl-CoA hydratase
DKE41_RS18240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE41_RS18275	COG0251	oxidation-reduction process
DKE41_RS18315	COG0564	pseudouridine synthase activity
DKE41_RS18390	COG1802	Transcriptional regulator
DKE41_RS18410	COG2186	Transcriptional regulator
DKE41_RS18425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE41_RS18545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE41_RS18605	COG3511	phospholipase C
DKE41_RS18645	COG0546	phosphoglycolate phosphatase activity
DKE41_RS18650	COG1028	Short-chain dehydrogenase reductase Sdr
DKE41_RS18695	COG1309	transcriptional regulator
DKE41_RS18725	COG1047	Peptidyl-prolyl cis-trans
DKE41_RS18765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE41_RS18850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE41_RS18905	COG1230	cation diffusion facilitator family transporter
DKE41_RS18970	COG4456	Virulence-associated protein
DKE41_RS18975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE41_RS19050	COG1162	GTPase activity
DKE41_RS19095	COG2161	toxin-antitoxin pair type II binding
DKE41_RS19100	COG4115	mRNA cleavage