locus-tag	class	description
DKE42_RS00010	COG0592	DNA-directed DNA polymerase activity
DKE42_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKE42_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKE42_RS00105	COG0625	glutathione transferase activity
DKE42_RS00115	COG0733	neurotransmitter:sodium symporter activity
DKE42_RS00155	COG2233	PERMEase
DKE42_RS00205	COG2814	Major facilitator Superfamily
DKE42_RS00210	COG0656	L-ascorbic acid biosynthetic process
DKE42_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE42_RS00240	COG2818	Glycosylase
DKE42_RS00255	COG1194	a g-specific adenine glycosylase
DKE42_RS00270	COG5487	UPF0391 membrane protein
DKE42_RS00275	COG2983	Belongs to the UPF0260 family
DKE42_RS00280	COG2133	pyrroloquinoline quinone binding
DKE42_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DKE42_RS00290	COG2116	formate transmembrane transporter activity
DKE42_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE42_RS00315	COG1335	isochorismatase
DKE42_RS00320	COG0385	Bile acid
DKE42_RS00325	COG0534	Mate efflux family protein
DKE42_RS00360	COG1113	amino acid transport
DKE42_RS00380	COG2188	Transcriptional regulator
DKE42_RS00420	COG0546	phosphoglycolate phosphatase activity
DKE42_RS00430	COG1280	lysine exporter protein (LysE YggA)
DKE42_RS00455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DKE42_RS00470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DKE42_RS00575	COG0534	Mate efflux family protein
DKE42_RS00655	COG3150	esterase
DKE42_RS00665	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKE42_RS00685	COG2233	PERMEase
DKE42_RS00690	COG2351	hydroxyisourate hydrolase activity
DKE42_RS00740	COG1393	Belongs to the ArsC family
DKE42_RS00745	COG0708	Exodeoxyribonuclease III
DKE42_RS00785	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKE42_RS00810	COG4942	peptidase
DKE42_RS00830	COG2119	membrane
DKE42_RS00840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_RS00840	COG0426	domain, Protein
DKE42_RS00910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE42_RS00920	COG1522	sequence-specific DNA binding
DKE42_RS00950	COG3162	membrane
DKE42_RS00955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE42_RS00985	COG1309	transcriptional regulator
DKE42_RS01005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE42_RS01005	COG0352	thiamine-phosphate diphosphorylase activity
DKE42_RS01005	COG0351	phosphomethylpyrimidine kinase
DKE42_RS01050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKE42_RS01055	COG1012	belongs to the aldehyde dehydrogenase family
DKE42_RS01065	COG1335	isochorismatase
DKE42_RS01110	COG0583	DNA-binding transcription factor activity
DKE42_RS01165	COG1733	regulation of RNA biosynthetic process
DKE42_RS01255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE42_RS01270	COG2329	Antibiotic biosynthesis monooxygenase
DKE42_RS01290	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DKE42_RS01300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE42_RS01360	COG4221	oxidoreductase activity
DKE42_RS01505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DKE42_RS01510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKE42_RS01575	COG0069	glutamate synthase activity
DKE42_RS01575	COG0070	glutamate synthase
DKE42_RS01575	COG0067	glutamate synthase
DKE42_RS01590	COG1704	LemA family
DKE42_RS01655	COG0194	GDP metabolic process
DKE42_RS01705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE42_RS01715	COG0335	large ribosomal subunit rRNA binding
DKE42_RS01730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DKE42_RS01760	COG0277	FAD linked oxidase domain protein
DKE42_RS01780	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE42_RS01815	COG1192	Involved in chromosome partitioning
DKE42_RS01850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE42_RS01855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE42_RS01910	COG0583	DNA-binding transcription factor activity
DKE42_RS01965	COG1983	PspC domain protein
DKE42_RS01990	COG0408	coproporphyrinogen oxidase activity
DKE42_RS02025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE42_RS02045	COG0598	Magnesium transport protein CorA
DKE42_RS02055	COG0494	nUDIX hydrolase
DKE42_RS02085	COG1946	Acyl-CoA thioesterase
DKE42_RS02105	COG1959	2 iron, 2 sulfur cluster binding
DKE42_RS02110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE42_RS02110	COG1017	nitric oxide dioxygenase activity
DKE42_RS02140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE42_RS02145	COG0088	Forms part of the polypeptide exit tunnel
DKE42_RS02315	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE42_RS02460	COG1183	phosphatidylcholine synthase activity
DKE42_RS02510	COG1309	transcriptional regulator
DKE42_RS02530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DKE42_RS02535	COG1960	acyl-CoA dehydrogenase activity
DKE42_RS02575	COG2969	positive regulation of protein catabolic process
DKE42_RS02585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE42_RS02595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKE42_RS02600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE42_RS02605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE42_RS02610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE42_RS02615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DKE42_RS02650	COG1408	metallophosphoesterase
DKE42_RS02660	COG2199	diguanylate cyclase activity
DKE42_RS02730	COG1607	acyl-coa hydrolase
DKE42_RS02765	COG2350	Protein conserved in bacteria
DKE42_RS02790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE42_RS02795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE42_RS02805	COG1862	Preprotein translocase
DKE42_RS02845	COG0726	polysaccharide deacetylase
DKE42_RS02910	COG0625	glutathione transferase activity
DKE42_RS02915	COG0583	DNA-binding transcription factor activity
DKE42_RS02970	COG2096	Adenosyltransferase
DKE42_RS03075	COG2153	protein acetylation
DKE42_RS03100	COG2207	Transcriptional regulator
DKE42_RS03120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE42_RS03150	COG2885	chlorophyll binding
DKE42_RS03150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE42_RS03175	COG1217	gtp-binding protein TYPA
DKE42_RS03200	COG2094	Belongs to the DNA glycosylase MPG family
DKE42_RS03210	COG1902	pentaerythritol trinitrate reductase activity
DKE42_RS03215	COG0679	Auxin Efflux Carrier
DKE42_RS03255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_RS03270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE42_RS03285	COG3189	MarR family transcriptional regulator
DKE42_RS03290	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE42_RS03295	COG3422	double-strand break repair
DKE42_RS03355	COG5510	response to toxic substance
DKE42_RS03365	COG2832	Protein of unknown function (DUF454)
DKE42_RS03420	COG1289	transmembrane transporter activity
DKE42_RS03425	COG2814	Major facilitator Superfamily
DKE42_RS03445	COG1115	amino acid carrier protein
DKE42_RS03455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKE42_RS03490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE42_RS03500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE42_RS03505	COG1077	Cell shape determining protein MreB Mrl
DKE42_RS03510	COG1792	Involved in formation and maintenance of cell shape
DKE42_RS03520	COG0424	maF-like protein
DKE42_RS03525	COG1530	ribonuclease E activity
DKE42_RS03535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE42_RS03580	COG2207	Transcriptional regulator
DKE42_RS03610	COG3046	protein related to deoxyribodipyrimidine photolyase
DKE42_RS03650	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE42_RS03680	COG0745	RESPONSE REGULATOR receiver
DKE42_RS03685	COG0642	Histidine kinase
DKE42_RS03700	COG0004	ammonium transporteR
DKE42_RS03705	COG0583	DNA-binding transcription factor activity
DKE42_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS03750	COG0393	Putative heavy-metal-binding
DKE42_RS03760	COG1538	Outer membrane efflux protein
DKE42_RS03805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKE42_RS03825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE42_RS03875	COG0321	lipoyl(octanoyl) transferase activity
DKE42_RS03880	COG2921	Belongs to the UPF0250 family
DKE42_RS03920	COG2009	succinate dehydrogenase
DKE42_RS03930	COG1053	succinate dehydrogenase
DKE42_RS03935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE42_RS04025	COG0589	response to stress
DKE42_RS04055	COG0505	Belongs to the CarA family
DKE42_RS04085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE42_RS04145	COG0477	Major facilitator Superfamily
DKE42_RS04150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DKE42_RS04300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE42_RS04335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE42_RS04370	COG1113	amino acid transport
DKE42_RS04455	COG4591	ABC-type transport system involved in lipoprotein release permease component
DKE42_RS04460	COG1136	(ABC) transporter
DKE42_RS04475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DKE42_RS04475	COG0616	signal peptide processing
DKE42_RS04480	COG0596	Alpha beta hydrolase
DKE42_RS04485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE42_RS04550	COG0823	Involved in the tonB-independent uptake of proteins
DKE42_RS04570	COG0824	Thioesterase
DKE42_RS04605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE42_RS04615	COG1056	cytidyltransferase-related domain
DKE42_RS04615	COG1051	belongs to the nudix hydrolase family
DKE42_RS04630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DKE42_RS04645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE42_RS04660	COG4625	pathogenesis
DKE42_RS04700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DKE42_RS04735	COG0481	GTPase activity
DKE42_RS04770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DKE42_RS04780	COG4221	oxidoreductase activity
DKE42_RS04830	COG0556	nucleotide-excision repair
DKE42_RS04900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE42_RS04940	COG1252	NADH dehydrogenase
DKE42_RS04980	COG0583	DNA-binding transcription factor activity
DKE42_RS04985	COG1823	symporter activity
DKE42_RS05025	COG0352	thiamine-phosphate diphosphorylase activity
DKE42_RS05080	COG0076	glutamate decarboxylase activity
DKE42_RS05090	COG1522	sequence-specific DNA binding
DKE42_RS05105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKE42_RS05160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE42_RS05165	COG1686	Belongs to the peptidase S11 family
DKE42_RS05240	COG1966	Carbon starvation protein
DKE42_RS05245	COG2879	small protein
DKE42_RS05290	COG1741	Belongs to the pirin family
DKE42_RS05320	COG4604	ABC transporter, ATP-binding protein
DKE42_RS05330	COG4774	siderophore transport
DKE42_RS05350	COG1535	isochorismatase
DKE42_RS05350	COG3433	isochorismatase activity
DKE42_RS05370	COG1132	(ABC) transporter
DKE42_RS05385	COG1169	isochorismate synthase
DKE42_RS05425	COG0302	gtp cyclohydrolase
DKE42_RS05480	COG0512	Glutamine amidotransferase of anthranilate synthase
DKE42_RS05735	COG0174	glutamine synthetase
DKE42_RS05780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE42_RS05815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE42_RS05840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE42_RS05845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE42_RS05865	COG0024	Methionine aminopeptidase
DKE42_RS05930	COG0842	Transport permease protein
DKE42_RS05940	COG0582	viral genome integration into host DNA
DKE42_RS06230	COG4215	(ABC) transporter
DKE42_RS06250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE42_RS06255	COG0826	peptidase U32
DKE42_RS06265	COG0384	phenazine biosynthesis protein PhzF
DKE42_RS06320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKE42_RS06325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE42_RS06330	COG3139	Protein of unknown function (DUF1315)
DKE42_RS06400	COG1690	Belongs to the RtcB family
DKE42_RS06405	COG1234	tRNA 3'-trailer cleavage
DKE42_RS06455	COG1278	Cold shock
DKE42_RS06460	COG0513	Belongs to the DEAD box helicase family
DKE42_RS06470	COG0778	Nitroreductase
DKE42_RS06530	COG1610	YqeY-like protein
DKE42_RS06585	COG1278	Cold shock
DKE42_RS06605	COG0786	glutamate:sodium symporter activity
DKE42_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS06690	COG2995	paraquat-inducible protein a
DKE42_RS06765	COG0745	RESPONSE REGULATOR receiver
DKE42_RS06810	COG1301	dicarboxylic acid transport
DKE42_RS06825	COG2011	ABC-type metal ion transport system permease component
DKE42_RS06890	COG1305	Transglutaminase-like
DKE42_RS06900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE42_RS06905	COG0305	Participates in initiation and elongation during chromosome replication
DKE42_RS06930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE42_RS06935	COG1845	cytochrome c oxidase, subunit III
DKE42_RS06940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE42_RS06980	COG3658	cytochrome
DKE42_RS07020	COG2890	protein-(glutamine-N5) methyltransferase activity
DKE42_RS07025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE42_RS07045	COG1960	acyl-CoA dehydrogenase activity
DKE42_RS07050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_RS07065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKE42_RS07095	COG0745	RESPONSE REGULATOR receiver
DKE42_RS07160	COG2814	Major facilitator Superfamily
DKE42_RS07170	COG0583	DNA-binding transcription factor activity
DKE42_RS07205	COG0802	atpase or kinase
DKE42_RS07220	COG1923	regulation of RNA biosynthetic process
DKE42_RS07250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKE42_RS07255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE42_RS07255	COG0519	Catalyzes the synthesis of GMP from XMP
DKE42_RS07260	COG4302	ethanolamine ammonia-lyase activity
DKE42_RS07295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE42_RS07360	COG1605	Chorismate mutase
DKE42_RS07445	COG1733	regulation of RNA biosynthetic process
DKE42_RS07510	COG0589	response to stress
DKE42_RS07565	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS07570	COG2030	dehydratase
DKE42_RS07635	COG1335	isochorismatase
DKE42_RS07685	COG0069	glutamate synthase activity
DKE42_RS07735	COG0511	ligase activity, forming carbon-carbon bonds
DKE42_RS07865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE42_RS07895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE42_RS07965	COG2204	response regulator
DKE42_RS08000	COG0575	Belongs to the CDS family
DKE42_RS08035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE42_RS08065	COG1011	Hydrolase
DKE42_RS08080	COG1522	sequence-specific DNA binding
DKE42_RS08150	COG1105	Belongs to the carbohydrate kinase PfkB family
DKE42_RS08175	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DKE42_RS08200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE42_RS08205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE42_RS08260	COG4890	Cyd operon protein YbgT
DKE42_RS08265	COG1294	oxidase, subunit
DKE42_RS08280	COG1585	Membrane protein implicated in regulation of membrane protease activity
DKE42_RS08290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKE42_RS08310	COG0569	domain protein
DKE42_RS08345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKE42_RS08360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE42_RS08450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE42_RS08460	COG0183	Belongs to the thiolase family
DKE42_RS08465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DKE42_RS08470	COG0596	Alpha beta hydrolase
DKE42_RS08475	COG2271	Major facilitator Superfamily
DKE42_RS08480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE42_RS08490	COG3485	protocatechuate 3,4-dioxygenase
DKE42_RS08500	COG3420	alginic acid biosynthetic process
DKE42_RS08520	COG2391	methyltransferase activity
DKE42_RS08535	COG1414	Transcriptional regulator
DKE42_RS08645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE42_RS08655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE42_RS08660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE42_RS08670	COG4829	muconolactone delta-isomerase
DKE42_RS08690	COG2186	Transcriptional regulator
DKE42_RS08710	COG1012	belongs to the aldehyde dehydrogenase family
DKE42_RS08715	COG2351	hydroxyisourate hydrolase activity
DKE42_RS08720	COG2233	PERMEase
DKE42_RS08735	COG2186	Transcriptional regulator
DKE42_RS08760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE42_RS08820	COG1309	transcriptional regulator
DKE42_RS08825	COG0583	DNA-binding transcription factor activity
DKE42_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS08860	COG0318	PFAM AMP-dependent synthetase and ligase
DKE42_RS08960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKE42_RS08965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DKE42_RS09045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE42_RS09060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE42_RS09160	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DKE42_RS09170	COG4628	conserved protein (DUF2132)
DKE42_RS09225	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE42_RS09265	COG2205	protein histidine kinase activity
DKE42_RS09270	COG0745	RESPONSE REGULATOR receiver
DKE42_RS09335	COG1535	isochorismatase
DKE42_RS09335	COG3433	isochorismatase activity
DKE42_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS09350	COG4149	molybdate abc transporter
DKE42_RS09355	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE42_RS09370	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE42_RS09375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE42_RS09375	COG0543	2 iron, 2 sulfur cluster binding
DKE42_RS09390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_RS09420	COG2207	Transcriptional regulator
DKE42_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS09430	COG2610	gluconate transmembrane transporter activity
DKE42_RS09470	COG0583	DNA-binding transcription factor activity
DKE42_RS09495	COG0583	DNA-binding transcription factor activity
DKE42_RS09560	COG0730	response to heat
DKE42_RS09590	COG1063	alcohol dehydrogenase
DKE42_RS09605	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE42_RS09615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE42_RS09620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE42_RS09695	COG0583	DNA-binding transcription factor activity
DKE42_RS09700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKE42_RS09800	COG0730	response to heat
DKE42_RS09875	COG1960	acyl-CoA dehydrogenase activity
DKE42_RS09885	COG2207	Transcriptional regulator
DKE42_RS09895	COG0776	regulation of translation
DKE42_RS09920	COG0822	iron-sulfur transferase activity
DKE42_RS10020	COG0601	transmembrane transport
DKE42_RS10080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DKE42_RS10100	COG2431	L-lysine efflux transmembrane transporter activity
DKE42_RS10115	COG0776	regulation of translation
DKE42_RS10180	COG0084	hydrolase, TatD family'
DKE42_RS10200	COG1663	tetraacyldisaccharide 4'-kinase activity
DKE42_RS10220	COG1475	DNA binding
DKE42_RS10290	COG0640	Transcriptional regulator
DKE42_RS10305	COG3122	Protein conserved in bacteria
DKE42_RS10330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKE42_RS10335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE42_RS10350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE42_RS10365	COG3698	Phosphodiester glycosidase
DKE42_RS10385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DKE42_RS10455	COG3539	Fimbrial protein
DKE42_RS10515	COG0583	DNA-binding transcription factor activity
DKE42_RS10545	COG1522	sequence-specific DNA binding
DKE42_RS10555	COG1126	abc transporter atp-binding protein
DKE42_RS10565	COG0765	amino acid transport
DKE42_RS10595	COG1464	Belongs to the NlpA lipoprotein family
DKE42_RS10605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE42_RS10615	COG0012	GTP binding
DKE42_RS10675	COG2207	Transcriptional regulator
DKE42_RS10675	COG1917	Cupin 2, conserved barrel domain protein
DKE42_RS10695	COG1301	dicarboxylic acid transport
DKE42_RS10745	COG0583	DNA-binding transcription factor activity
DKE42_RS10750	COG0431	NADPH-dependent FMN reductase
DKE42_RS10765	COG0640	Transcriptional regulator
DKE42_RS10815	COG2175	clavaminate synthase activity
DKE42_RS10820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE42_RS10865	COG1294	oxidase, subunit
DKE42_RS10920	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DKE42_RS10945	COG1346	cytolysis
DKE42_RS11005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKE42_RS11010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DKE42_RS11045	COG0765	amino acid transport
DKE42_RS11050	COG0765	amino acid transport
DKE42_RS11095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE42_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS11200	COG1960	acyl-CoA dehydrogenase activity
DKE42_RS11225	COG0583	DNA-binding transcription factor activity
DKE42_RS11265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE42_RS11315	COG1024	Enoyl-CoA hydratase
DKE42_RS11330	COG1960	acyl-CoA dehydrogenase activity
DKE42_RS11345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DKE42_RS11395	COG0583	DNA-binding transcription factor activity
DKE42_RS11440	COG2050	protein possibly involved in aromatic compounds catabolism
DKE42_RS11450	COG3327	negative regulation of DNA-templated transcription, initiation
DKE42_RS11460	COG0183	Belongs to the thiolase family
DKE42_RS11485	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE42_RS11495	COG3460	Phenylacetate-CoA oxygenase
DKE42_RS11500	COG3396	Phenylacetate-CoA oxygenase
DKE42_RS11530	COG0789	Transcriptional regulator
DKE42_RS11565	COG0590	tRNA wobble adenosine to inosine editing
DKE42_RS11570	COG0666	response to abiotic stimulus
DKE42_RS11655	COG0038	chloride channel
DKE42_RS11660	COG4770	biotin carboxylase activity
DKE42_RS11705	COG3220	belongs to the UPF0276 family
DKE42_RS11795	COG1051	belongs to the nudix hydrolase family
DKE42_RS11855	COG3038	cytochrome b561
DKE42_RS11865	COG1733	regulation of RNA biosynthetic process
DKE42_RS11900	COG0531	amino acid
DKE42_RS11935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE42_RS11945	COG4122	O-methyltransferase activity
DKE42_RS11975	COG1538	Outer membrane efflux protein
DKE42_RS11980	COG1137	ATPase activity
DKE42_RS11985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE42_RS11995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKE42_RS12050	COG0668	transmembrane transport
DKE42_RS12110	COG2226	methyltransferase
DKE42_RS12135	COG1560	Kdo2-lipid A biosynthetic process
DKE42_RS12140	COG1280	lysine exporter protein (LysE YggA)
DKE42_RS12280	COG4638	Rieske (2fe-2S)
DKE42_RS12285	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE42_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS12325	COG1643	Atp-dependent helicase
DKE42_RS12350	COG3634	alkyl hydroperoxide reductase activity
DKE42_RS12370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE42_RS12390	COG0625	glutathione transferase activity
DKE42_RS12450	COG1765	OsmC-like protein
DKE42_RS12465	COG0667	Aldo Keto reductase
DKE42_RS12480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE42_RS12560	COG1598	PFAM Uncharacterised protein family UPF0150
DKE42_RS12895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE42_RS13035	COG2186	Transcriptional regulator
DKE42_RS13195	COG4269	membrane
DKE42_RS13240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE42_RS13265	COG4172	Belongs to the ABC transporter superfamily
DKE42_RS13270	COG4239	(ABC) transporter, permease
DKE42_RS13330	COG0583	DNA-binding transcription factor activity
DKE42_RS13335	COG1279	arginine transmembrane transporter activity
DKE42_RS13355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE42_RS13430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE42_RS13440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKE42_RS13470	COG0742	ribosomal rna small subunit methyltransferase
DKE42_RS13495	COG0804	urea catabolic process
DKE42_RS13520	COG3015	lipoprotein NlpE involved in copper resistance
DKE42_RS13590	COG1773	rubredoxin
DKE42_RS13600	COG2267	carboxylic ester hydrolase activity
DKE42_RS13605	COG0583	DNA-binding transcription factor activity
DKE42_RS13640	COG4181	ATPase activity
DKE42_RS13705	COG0306	phosphate transporter
DKE42_RS13740	COG2223	nitrite transmembrane transporter activity
DKE42_RS13745	COG2207	Transcriptional regulator
DKE42_RS13750	COG2066	Belongs to the glutaminase family
DKE42_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS13790	COG2267	carboxylic ester hydrolase activity
DKE42_RS13805	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKE42_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS13835	COG1414	Transcriptional regulator
DKE42_RS13860	COG1215	transferase activity, transferring glycosyl groups
DKE42_RS13885	COG0523	cobalamin synthesis protein
DKE42_RS13895	COG1607	acyl-coa hydrolase
DKE42_RS14160	COG0735	belongs to the Fur family
DKE42_RS14190	COG0121	glutamine amidotransferase
DKE42_RS14220	COG2885	chlorophyll binding
DKE42_RS14240	COG2894	cell division
DKE42_RS14265	COG0492	ferredoxin-NADP+ reductase activity
DKE42_RS14280	COG0456	acetyltransferase
DKE42_RS14295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE42_RS14310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DKE42_RS14325	COG1981	membrane
DKE42_RS14355	COG1012	belongs to the aldehyde dehydrogenase family
DKE42_RS14365	COG0657	acetylesterase activity
DKE42_RS14400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE42_RS14550	COG1399	metal-binding, possibly nucleic acid-binding protein
DKE42_RS14555	COG3101	peptidyl-lysine hydroxylation
DKE42_RS14560	COG0009	L-threonylcarbamoyladenylate synthase
DKE42_RS14600	COG0596	Alpha beta hydrolase
DKE42_RS14600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE42_RS14600	COG2226	methyltransferase
DKE42_RS14610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DKE42_RS14615	COG2223	nitrite transmembrane transporter activity
DKE42_RS14670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE42_RS14805	COG0583	DNA-binding transcription factor activity
DKE42_RS14825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKE42_RS14830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKE42_RS14860	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DKE42_RS14900	COG0745	RESPONSE REGULATOR receiver
DKE42_RS15020	COG0789	Transcriptional regulator
DKE42_RS15100	COG0110	maltose O-acetyltransferase activity
DKE42_RS15175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE42_RS15190	COG0583	DNA-binding transcription factor activity
DKE42_RS15245	COG0583	DNA-binding transcription factor activity
DKE42_RS15265	COG0583	DNA-binding transcription factor activity
DKE42_RS15355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE42_RS15390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE42_RS15410	COG1214	PFAM Peptidase M22, glycoprotease
DKE42_RS15470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE42_RS15475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE42_RS15540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE42_RS15555	COG1764	response to oxidative stress
DKE42_RS15655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE42_RS15675	COG0625	glutathione transferase activity
DKE42_RS15700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE42_RS15730	COG1555	photosystem II stabilization
DKE42_RS15740	COG4221	oxidoreductase activity
DKE42_RS15765	COG0784	Response regulator, receiver
DKE42_RS15765	COG5002	protein histidine kinase activity
DKE42_RS15765	COG2205	protein histidine kinase activity
DKE42_RS15770	COG1024	Enoyl-CoA hydratase
DKE42_RS15855	COG2072	flavoprotein involved in K transport
DKE42_RS15860	COG0492	ferredoxin-NADP+ reductase activity
DKE42_RS15880	COG0640	Transcriptional regulator
DKE42_RS16040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE42_RS16075	COG0084	hydrolase, TatD family'
DKE42_RS16110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKE42_RS16115	COG0440	acetolactate synthase activity
DKE42_RS16120	COG0028	Belongs to the TPP enzyme family
DKE42_RS16140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE42_RS16180	COG1162	GTPase activity
DKE42_RS16190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE42_RS16210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE42_RS16230	COG1426	Protein conserved in bacteria
DKE42_RS16265	COG0793	Belongs to the peptidase S41A family
DKE42_RS16295	COG3265	gluconokinase activity
DKE42_RS16305	COG0800	Aldolase
DKE42_RS16330	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE42_RS16330	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE42_RS16350	COG0740	serine-type endopeptidase activity
DKE42_RS16380	COG2813	Specifically methylates the guanine in position
DKE42_RS16380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE42_RS16480	COG0788	formyltetrahydrofolate deformylase activity
DKE42_RS16505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKE42_RS16505	COG4651	solute:proton antiporter activity
DKE42_RS16525	COG0724	RNA recognition motif
DKE42_RS16555	COG1733	regulation of RNA biosynthetic process
DKE42_RS16560	COG0604	alcohol dehydrogenase
DKE42_RS16565	COG2900	Belongs to the SlyX family
DKE42_RS16570	COG0488	(ABC) transporter
DKE42_RS16580	COG1560	Kdo2-lipid A biosynthetic process
DKE42_RS16645	COG0473	3-isopropylmalate dehydrogenase activity
DKE42_RS16670	COG0583	DNA-binding transcription factor activity
DKE42_RS16725	COG0625	glutathione transferase activity
DKE42_RS16730	COG2378	regulation of single-species biofilm formation
DKE42_RS16735	COG0546	phosphoglycolate phosphatase activity
DKE42_RS16750	COG0318	PFAM AMP-dependent synthetase and ligase
DKE42_RS16765	COG0583	DNA-binding transcription factor activity
DKE42_RS16775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKE42_RS16825	COG0493	'glutamate synthase
DKE42_RS16835	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE42_RS16840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE42_RS16855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE42_RS16865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DKE42_RS16865	COG0644	oxidoreductase
DKE42_RS16880	COG4535	Mg2 and Co2 transporter CorC
DKE42_RS16890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE42_RS16920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE42_RS16935	COG0789	Transcriptional regulator
DKE42_RS16940	COG0598	Magnesium transport protein CorA
DKE42_RS16955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DKE42_RS16960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE42_RS16990	COG2226	methyltransferase
DKE42_RS17005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE42_RS17040	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE42_RS17055	COG2212	antiporter activity
DKE42_RS17060	COG1320	monovalent cation:proton antiporter activity
DKE42_RS17065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE42_RS17125	COG0237	dephospho-CoA kinase activity
DKE42_RS17135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE42_RS17150	COG0497	DNA recombination
DKE42_RS17195	COG2169	Transcriptional regulator
DKE42_RS17195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE42_RS17200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE42_RS17285	COG0326	Molecular chaperone. Has ATPase activity
DKE42_RS17300	COG2056	Na+-H+ antiporter family
DKE42_RS17405	COG1716	ATPase activity
DKE42_RS17450	COG0181	hydroxymethylbilane synthase activity
DKE42_RS17515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKE42_RS17520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE42_RS17525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKE42_RS17530	COG0772	Belongs to the SEDS family
DKE42_RS17555	COG4974	Belongs to the 'phage' integrase family
DKE42_RS17560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKE42_RS17570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE42_RS17595	COG0793	Belongs to the peptidase S41A family
DKE42_RS17600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DKE42_RS17655	COG0004	ammonium transporteR
DKE42_RS17670	COG0606	chelatase, subunit chli
DKE42_RS17675	COG0431	NADPH-dependent FMN reductase
DKE42_RS17685	COG0235	Class ii aldolase
DKE42_RS17690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE42_RS17710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DKE42_RS17735	COG0477	Major facilitator Superfamily
DKE42_RS17740	COG2860	membrane
DKE42_RS17750	COG1253	flavin adenine dinucleotide binding
DKE42_RS17760	COG2814	Major facilitator Superfamily
DKE42_RS17805	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE42_RS17850	COG1309	transcriptional regulator
DKE42_RS17895	COG0697	spore germination
DKE42_RS17930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE42_RS17980	COG1121	(ABC) transporter
DKE42_RS17985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE42_RS17990	COG1280	lysine exporter protein (LysE YggA)
DKE42_RS18000	COG0281	malic enzyme
DKE42_RS18050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE42_RS18050	COG0519	Catalyzes the synthesis of GMP from XMP
DKE42_RS18060	COG2259	Doxx family
DKE42_RS18065	COG0586	Pfam SNARE associated Golgi protein
DKE42_RS18090	COG0271	Belongs to the BolA IbaG family
DKE42_RS18140	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DKE42_RS18140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKE42_RS18140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE42_RS18140	COG3321	synthase
DKE42_RS18165	COG3916	Acyl-homoserine-lactone synthase
DKE42_RS18170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE42_RS18185	COG1113	amino acid transport
DKE42_RS18190	COG0697	spore germination
DKE42_RS18210	COG1960	acyl-CoA dehydrogenase activity
DKE42_RS18240	COG1113	amino acid transport
DKE42_RS18245	COG0251	oxidation-reduction process
DKE42_RS18285	COG0564	pseudouridine synthase activity
DKE42_RS18335	COG2801	Transposase and inactivated derivatives
DKE42_RS18385	COG1802	Transcriptional regulator
DKE42_RS18395	COG1448	Aminotransferase
DKE42_RS18445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DKE42_RS18450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKE42_RS18475	COG2244	polysaccharide biosynthetic process
DKE42_RS18490	COG1091	dTDP-4-dehydrorhamnose reductase activity
DKE42_RS18535	COG3023	N-Acetylmuramoyl-L-alanine amidase
DKE42_RS18590	COG0546	phosphoglycolate phosphatase activity
DKE42_RS18595	COG1028	Short-chain dehydrogenase reductase Sdr
DKE42_RS18640	COG1309	transcriptional regulator
DKE42_RS18670	COG1047	Peptidyl-prolyl cis-trans
DKE42_RS18715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE42_RS18790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE42_RS18805	COG0861	Integral membrane protein TerC family
DKE42_RS18830	COG0402	S-adenosylhomocysteine deaminase activity
DKE42_RS18850	COG1230	cation diffusion facilitator family transporter
DKE42_RS18915	COG0604	alcohol dehydrogenase
DKE42_RS18915	COG3321	synthase
DKE42_RS18960	COG2801	Transposase and inactivated derivatives
DKE42_RS18985	COG3077	Addiction module antitoxin, RelB DinJ family
DKE42_RS19000	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
DKE42_RS19020	COG2801	Transposase and inactivated derivatives
DKE42_RS19285	COG1475	DNA binding
DKE42_RS19290	COG1192	Involved in chromosome partitioning
DKE42_RS19320	COG0604	alcohol dehydrogenase
DKE42_RS19325	COG0604	alcohol dehydrogenase
DKE42_RS19415	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE42_RS19560	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE42_RS19575	COG2801	Transposase and inactivated derivatives
DKE42_RS19595	COG0488	(ABC) transporter
DKE42_RS19695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair