locus-tag	class	description
DKE45_RS00010	COG0592	DNA-directed DNA polymerase activity
DKE45_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKE45_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKE45_RS00105	COG0625	glutathione transferase activity
DKE45_RS00155	COG2233	PERMEase
DKE45_RS00205	COG2814	Major facilitator Superfamily
DKE45_RS00270	COG5487	UPF0391 membrane protein
DKE45_RS00275	COG2983	Belongs to the UPF0260 family
DKE45_RS00280	COG2133	pyrroloquinoline quinone binding
DKE45_RS00290	COG2116	formate transmembrane transporter activity
DKE45_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE45_RS00315	COG1335	isochorismatase
DKE45_RS00325	COG0534	Mate efflux family protein
DKE45_RS00330	COG1683	Conserved Protein
DKE45_RS00370	COG0523	cobalamin synthesis protein
DKE45_RS00380	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_RS00465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DKE45_RS00475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKE45_RS00590	COG0436	Aminotransferase
DKE45_RS00595	COG2733	membrane
DKE45_RS00665	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKE45_RS00685	COG2233	PERMEase
DKE45_RS00690	COG2351	hydroxyisourate hydrolase activity
DKE45_RS00725	COG3706	GGDEF domain
DKE45_RS00745	COG0708	Exodeoxyribonuclease III
DKE45_RS00810	COG4942	peptidase
DKE45_RS00840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_RS00840	COG0426	domain, Protein
DKE45_RS00860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DKE45_RS00880	COG1902	pentaerythritol trinitrate reductase activity
DKE45_RS00915	COG1522	sequence-specific DNA binding
DKE45_RS00945	COG3162	membrane
DKE45_RS00995	COG1309	transcriptional regulator
DKE45_RS01025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE45_RS01025	COG0351	phosphomethylpyrimidine kinase
DKE45_RS01025	COG0352	thiamine-phosphate diphosphorylase activity
DKE45_RS01060	COG1113	amino acid transport
DKE45_RS01085	COG1335	isochorismatase
DKE45_RS01130	COG0583	DNA-binding transcription factor activity
DKE45_RS01150	COG0667	Aldo Keto reductase
DKE45_RS01160	COG2801	Transposase and inactivated derivatives
DKE45_RS01175	COG1309	transcriptional regulator
DKE45_RS01200	COG1733	regulation of RNA biosynthetic process
DKE45_RS01245	COG3177	Filamentation induced by cAMP protein fic
DKE45_RS01290	COG2801	Transposase and inactivated derivatives
DKE45_RS01445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE45_RS01460	COG2329	Antibiotic biosynthesis monooxygenase
DKE45_RS01485	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DKE45_RS01495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE45_RS01555	COG4221	oxidoreductase activity
DKE45_RS01560	COG2873	o-acetylhomoserine
DKE45_RS01695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DKE45_RS01765	COG0070	glutamate synthase
DKE45_RS01765	COG0069	glutamate synthase activity
DKE45_RS01765	COG0067	glutamate synthase
DKE45_RS01780	COG1704	LemA family
DKE45_RS01840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKE45_RS01855	COG0194	GDP metabolic process
DKE45_RS01905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE45_RS01915	COG0335	large ribosomal subunit rRNA binding
DKE45_RS01970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE45_RS01975	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE45_RS02000	COG0628	permease
DKE45_RS02005	COG1192	Involved in chromosome partitioning
DKE45_RS02045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE45_RS02095	COG0583	DNA-binding transcription factor activity
DKE45_RS02145	COG0517	IMP dehydrogenase activity
DKE45_RS02145	COG0617	tRNA 3'-terminal CCA addition
DKE45_RS02145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DKE45_RS02150	COG1983	PspC domain protein
DKE45_RS02160	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_RS02170	COG1960	acyl-CoA dehydrogenase activity
DKE45_RS02220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKE45_RS02240	COG0598	Magnesium transport protein CorA
DKE45_RS02250	COG0494	nUDIX hydrolase
DKE45_RS02255	COG1040	competence protein
DKE45_RS02275	COG2937	Belongs to the GPAT DAPAT family
DKE45_RS02280	COG1946	Acyl-CoA thioesterase
DKE45_RS02300	COG1959	2 iron, 2 sulfur cluster binding
DKE45_RS02315	COG0433	COG0433 Predicted ATPase
DKE45_RS02335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE45_RS02340	COG0088	Forms part of the polypeptide exit tunnel
DKE45_RS02480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKE45_RS02510	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DKE45_RS02570	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE45_RS02655	COG1183	phosphatidylcholine synthase activity
DKE45_RS02705	COG1309	transcriptional regulator
DKE45_RS02730	COG1960	acyl-CoA dehydrogenase activity
DKE45_RS02765	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_RS02775	COG2969	positive regulation of protein catabolic process
DKE45_RS02785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE45_RS02795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKE45_RS02825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKE45_RS02835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE45_RS02840	COG1408	metallophosphoesterase
DKE45_RS02845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE45_RS02845	COG2885	chlorophyll binding
DKE45_RS02850	COG2199	diguanylate cyclase activity
DKE45_RS02920	COG1607	acyl-coa hydrolase
DKE45_RS02955	COG2350	Protein conserved in bacteria
DKE45_RS02970	COG3781	membrane
DKE45_RS02980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE45_RS02985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE45_RS02995	COG1862	Preprotein translocase
DKE45_RS03115	COG0625	glutathione transferase activity
DKE45_RS03120	COG0583	DNA-binding transcription factor activity
DKE45_RS03130	COG1960	acyl-CoA dehydrogenase activity
DKE45_RS03225	COG0285	dihydrofolate synthase activity
DKE45_RS03275	COG2153	protein acetylation
DKE45_RS03300	COG2207	Transcriptional regulator
DKE45_RS03320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE45_RS03350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE45_RS03350	COG2885	chlorophyll binding
DKE45_RS03375	COG1217	gtp-binding protein TYPA
DKE45_RS03400	COG2094	Belongs to the DNA glycosylase MPG family
DKE45_RS03455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_RS03470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE45_RS03485	COG3189	MarR family transcriptional regulator
DKE45_RS03490	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE45_RS03495	COG3422	double-strand break repair
DKE45_RS03555	COG5510	response to toxic substance
DKE45_RS03565	COG2832	Protein of unknown function (DUF454)
DKE45_RS03570	COG1376	ErfK ybiS ycfS ynhG family protein
DKE45_RS03645	COG1115	amino acid carrier protein
DKE45_RS03660	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DKE45_RS03700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE45_RS03710	COG1792	Involved in formation and maintenance of cell shape
DKE45_RS03715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DKE45_RS03720	COG0424	maF-like protein
DKE45_RS03725	COG1530	ribonuclease E activity
DKE45_RS03755	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE45_RS03830	COG0142	geranyltranstransferase activity
DKE45_RS03850	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE45_RS03875	COG2194	sulfuric ester hydrolase activity
DKE45_RS03880	COG0745	RESPONSE REGULATOR receiver
DKE45_RS03885	COG0642	Histidine kinase
DKE45_RS03955	COG0393	Putative heavy-metal-binding
DKE45_RS04020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE45_RS04055	COG0531	amino acid
DKE45_RS04075	COG2921	Belongs to the UPF0250 family
DKE45_RS04115	COG2009	succinate dehydrogenase
DKE45_RS04125	COG1053	succinate dehydrogenase
DKE45_RS04130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE45_RS04250	COG0589	response to stress
DKE45_RS04280	COG0505	Belongs to the CarA family
DKE45_RS04360	COG2264	protein methyltransferase activity
DKE45_RS04370	COG0477	Major facilitator Superfamily
DKE45_RS04390	COG1597	lipid kinase activity
DKE45_RS04465	COG2801	Transposase and inactivated derivatives
DKE45_RS04540	COG2814	Major facilitator Superfamily
DKE45_RS04585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE45_RS04610	COG0741	lytic transglycosylase activity
DKE45_RS04635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DKE45_RS04665	COG2801	Transposase and inactivated derivatives
DKE45_RS04690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE45_RS04720	COG0243	molybdopterin cofactor binding
DKE45_RS04730	COG3339	Conserved Protein
DKE45_RS04755	COG1115	amino acid carrier protein
DKE45_RS04850	COG1136	(ABC) transporter
DKE45_RS04875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DKE45_RS04875	COG0616	signal peptide processing
DKE45_RS04885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE45_RS04950	COG0823	Involved in the tonB-independent uptake of proteins
DKE45_RS04970	COG0824	Thioesterase
DKE45_RS05000	COG2814	Major facilitator Superfamily
DKE45_RS05005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE45_RS05010	COG1024	Enoyl-CoA hydratase
DKE45_RS05015	COG1056	cytidyltransferase-related domain
DKE45_RS05015	COG1051	belongs to the nudix hydrolase family
DKE45_RS05045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE45_RS05060	COG4625	pathogenesis
DKE45_RS05070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKE45_RS05080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKE45_RS05135	COG0681	Belongs to the peptidase S26 family
DKE45_RS05145	COG0571	ribonuclease III activity
DKE45_RS05165	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DKE45_RS05225	COG0556	nucleotide-excision repair
DKE45_RS05295	COG2070	2-Nitropropane dioxygenase
DKE45_RS05310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE45_RS05410	COG1823	symporter activity
DKE45_RS05445	COG0352	thiamine-phosphate diphosphorylase activity
DKE45_RS05510	COG1522	sequence-specific DNA binding
DKE45_RS05525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKE45_RS05545	COG0616	signal peptide processing
DKE45_RS05590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE45_RS05595	COG1686	Belongs to the peptidase S11 family
DKE45_RS05665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKE45_RS05710	COG2801	Transposase and inactivated derivatives
DKE45_RS05730	COG1741	Belongs to the pirin family
DKE45_RS05750	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE45_RS05755	COG4605	iron ion homeostasis
DKE45_RS05760	COG4604	ABC transporter, ATP-binding protein
DKE45_RS05765	COG4607	ABC-type enterochelin transport system periplasmic component
DKE45_RS05795	COG1132	(ABC) transporter
DKE45_RS05805	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DKE45_RS05855	COG0302	gtp cyclohydrolase
DKE45_RS05910	COG0512	Glutamine amidotransferase of anthranilate synthase
DKE45_RS06205	COG0174	glutamine synthetase
DKE45_RS06250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE45_RS06255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE45_RS06260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKE45_RS06285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE45_RS06310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE45_RS06315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE45_RS06385	COG2951	lytic endotransglycosylase activity
DKE45_RS06390	COG0772	Belongs to the SEDS family
DKE45_RS06405	COG0842	Transport permease protein
DKE45_RS06410	COG1131	(ABC) transporter
DKE45_RS06490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE45_RS06505	COG0384	phenazine biosynthesis protein PhzF
DKE45_RS06550	COG0494	nUDIX hydrolase
DKE45_RS06565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE45_RS06570	COG3139	Protein of unknown function (DUF1315)
DKE45_RS06575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKE45_RS06620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE45_RS06625	COG2195	Cleaves the N-terminal amino acid of tripeptides
DKE45_RS06645	COG1690	Belongs to the RtcB family
DKE45_RS06715	COG0778	Nitroreductase
DKE45_RS06775	COG1610	YqeY-like protein
DKE45_RS06915	COG2995	paraquat-inducible protein a
DKE45_RS06930	COG2351	hydroxyisourate hydrolase activity
DKE45_RS06980	COG0642	Histidine kinase
DKE45_RS06985	COG0745	RESPONSE REGULATOR receiver
DKE45_RS07000	COG1794	racemase activity, acting on amino acids and derivatives
DKE45_RS07030	COG1301	dicarboxylic acid transport
DKE45_RS07050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE45_RS07070	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DKE45_RS07110	COG1305	Transglutaminase-like
DKE45_RS07120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE45_RS07125	COG0305	Participates in initiation and elongation during chromosome replication
DKE45_RS07150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE45_RS07200	COG3658	cytochrome
DKE45_RS07210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE45_RS07245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE45_RS07270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_RS07285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKE45_RS07295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DKE45_RS07315	COG0745	RESPONSE REGULATOR receiver
DKE45_RS07320	COG0174	glutamine synthetase
DKE45_RS07340	COG0729	surface antigen
DKE45_RS07420	COG0802	atpase or kinase
DKE45_RS07435	COG1923	regulation of RNA biosynthetic process
DKE45_RS07440	COG0697	spore germination
DKE45_RS07470	COG0519	Catalyzes the synthesis of GMP from XMP
DKE45_RS07470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE45_RS07665	COG1733	regulation of RNA biosynthetic process
DKE45_RS07690	COG0583	DNA-binding transcription factor activity
DKE45_RS07730	COG0589	response to stress
DKE45_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS07795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DKE45_RS07855	COG1335	isochorismatase
DKE45_RS07955	COG0511	ligase activity, forming carbon-carbon bonds
DKE45_RS07985	COG4264	IucA IucC family
DKE45_RS08010	COG1116	anion transmembrane transporter activity
DKE45_RS08010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DKE45_RS08055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKE45_RS08070	COG0521	Mo-molybdopterin cofactor biosynthetic process
DKE45_RS08070	COG0315	cyclic pyranopterin monophosphate synthase activity
DKE45_RS08115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE45_RS08185	COG2204	response regulator
DKE45_RS08190	COG3852	Histidine kinase
DKE45_RS08220	COG0575	Belongs to the CDS family
DKE45_RS08255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE45_RS08270	COG2137	regulation of response to DNA damage stimulus
DKE45_RS08285	COG1011	Hydrolase
DKE45_RS08320	COG0659	secondary active sulfate transmembrane transporter activity
DKE45_RS08395	COG0024	Methionine aminopeptidase
DKE45_RS08410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE45_RS08415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE45_RS08470	COG4890	Cyd operon protein YbgT
DKE45_RS08475	COG1294	oxidase, subunit
DKE45_RS08490	COG1585	Membrane protein implicated in regulation of membrane protease activity
DKE45_RS08515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DKE45_RS08560	COG0542	response to heat
DKE45_RS08570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE45_RS08625	COG0148	phosphopyruvate hydratase activity
DKE45_RS08655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE45_RS08675	COG0183	Belongs to the thiolase family
DKE45_RS08685	COG0596	Alpha beta hydrolase
DKE45_RS08690	COG2271	Major facilitator Superfamily
DKE45_RS08695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE45_RS08705	COG3485	protocatechuate 3,4-dioxygenase
DKE45_RS08735	COG2391	methyltransferase activity
DKE45_RS08750	COG1414	Transcriptional regulator
DKE45_RS08860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE45_RS08865	COG0183	Belongs to the thiolase family
DKE45_RS08885	COG4829	muconolactone delta-isomerase
DKE45_RS08890	COG4948	Mandelate Racemase Muconate Lactonizing
DKE45_RS08905	COG2186	Transcriptional regulator
DKE45_RS08930	COG2351	hydroxyisourate hydrolase activity
DKE45_RS08935	COG2233	PERMEase
DKE45_RS08950	COG2186	Transcriptional regulator
DKE45_RS08990	COG1902	pentaerythritol trinitrate reductase activity
DKE45_RS08990	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKE45_RS09030	COG1309	transcriptional regulator
DKE45_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS09070	COG0318	PFAM AMP-dependent synthetase and ligase
DKE45_RS09240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE45_RS09305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DKE45_RS09320	COG2801	Transposase and inactivated derivatives
DKE45_RS09375	COG4628	conserved protein (DUF2132)
DKE45_RS09390	COG3539	Fimbrial protein
DKE45_RS09415	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE45_RS09450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE45_RS09470	COG0745	RESPONSE REGULATOR receiver
DKE45_RS09475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE45_RS09535	COG3433	isochorismatase activity
DKE45_RS09535	COG1535	isochorismatase
DKE45_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS09555	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE45_RS09565	COG4638	Rieske (2fe-2S)
DKE45_RS09570	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE45_RS09575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE45_RS09575	COG0543	2 iron, 2 sulfur cluster binding
DKE45_RS09590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_RS09625	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS09670	COG0583	DNA-binding transcription factor activity
DKE45_RS09690	COG0183	Belongs to the thiolase family
DKE45_RS09695	COG0583	DNA-binding transcription factor activity
DKE45_RS09730	COG0730	response to heat
DKE45_RS09770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE45_RS09775	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE45_RS09780	COG0022	dehydrogenase e1 component
DKE45_RS09785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE45_RS09790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE45_RS09805	COG3706	GGDEF domain
DKE45_RS09825	COG0133	tryptophan synthase activity
DKE45_RS09835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE45_RS09865	COG0583	DNA-binding transcription factor activity
DKE45_RS09870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKE45_RS09970	COG0730	response to heat
DKE45_RS09975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE45_RS09995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DKE45_RS10025	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKE45_RS10045	COG1960	acyl-CoA dehydrogenase activity
DKE45_RS10050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKE45_RS10090	COG0822	iron-sulfur transferase activity
DKE45_RS10245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DKE45_RS10365	COG1663	tetraacyldisaccharide 4'-kinase activity
DKE45_RS10370	COG1132	(ABC) transporter
DKE45_RS10380	COG0811	peptide transport
DKE45_RS10390	COG1192	Involved in chromosome partitioning
DKE45_RS10415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKE45_RS10440	COG0424	maF-like protein
DKE45_RS10455	COG0640	Transcriptional regulator
DKE45_RS10500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE45_RS10515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE45_RS10530	COG3698	Phosphodiester glycosidase
DKE45_RS10595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DKE45_RS10595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DKE45_RS10660	COG0583	DNA-binding transcription factor activity
DKE45_RS10670	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_RS10730	COG1522	sequence-specific DNA binding
DKE45_RS10745	COG1126	abc transporter atp-binding protein
DKE45_RS10750	COG0765	amino acid transport
DKE45_RS10755	COG0765	amino acid transport
DKE45_RS10800	COG2011	ABC-type metal ion transport system permease component
DKE45_RS10805	COG0012	GTP binding
DKE45_RS10830	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DKE45_RS10920	COG3634	alkyl hydroperoxide reductase activity
DKE45_RS10940	COG0431	NADPH-dependent FMN reductase
DKE45_RS10955	COG0640	Transcriptional regulator
DKE45_RS11010	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DKE45_RS11050	COG1271	oxidase subunit
DKE45_RS11055	COG1294	oxidase, subunit
DKE45_RS11065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE45_RS11120	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DKE45_RS11145	COG1346	cytolysis
DKE45_RS11165	COG0625	glutathione transferase activity
DKE45_RS11230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE45_RS11290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE45_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS11400	COG1309	transcriptional regulator
DKE45_RS11415	COG1024	Enoyl-CoA hydratase
DKE45_RS11420	COG4770	biotin carboxylase activity
DKE45_RS11470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE45_RS11480	COG1960	acyl-CoA dehydrogenase activity
DKE45_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS11495	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKE45_RS11515	COG2814	Major facilitator Superfamily
DKE45_RS11520	COG2814	Major facilitator Superfamily
DKE45_RS11545	COG1960	acyl-CoA dehydrogenase activity
DKE45_RS11550	COG2814	Major facilitator Superfamily
DKE45_RS11560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DKE45_RS11610	COG0583	DNA-binding transcription factor activity
DKE45_RS11660	COG2050	protein possibly involved in aromatic compounds catabolism
DKE45_RS11670	COG3327	negative regulation of DNA-templated transcription, initiation
DKE45_RS11680	COG0183	Belongs to the thiolase family
DKE45_RS11690	COG1024	Enoyl-CoA hydratase
DKE45_RS11695	COG1024	Enoyl-CoA hydratase
DKE45_RS11705	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE45_RS11710	COG3396	Phenylacetate-CoA oxygenase
DKE45_RS11715	COG3460	Phenylacetate-CoA oxygenase
DKE45_RS11720	COG3396	Phenylacetate-CoA oxygenase
DKE45_RS11750	COG0789	Transcriptional regulator
DKE45_RS11760	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKE45_RS11785	COG0590	tRNA wobble adenosine to inosine editing
DKE45_RS11790	COG0666	response to abiotic stimulus
DKE45_RS11830	COG1063	alcohol dehydrogenase
DKE45_RS11920	COG4770	biotin carboxylase activity
DKE45_RS12020	COG0531	amino acid
DKE45_RS12040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKE45_RS12055	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE45_RS12065	COG4122	O-methyltransferase activity
DKE45_RS12095	COG1538	Outer membrane efflux protein
DKE45_RS12100	COG1137	ATPase activity
DKE45_RS12105	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE45_RS12115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKE45_RS12185	COG0668	transmembrane transport
DKE45_RS12240	COG2226	methyltransferase
DKE45_RS12280	COG1278	Cold shock
DKE45_RS12330	COG1570	exodeoxyribonuclease VII activity
DKE45_RS12410	COG2871	sodium ion transport
DKE45_RS12430	COG4638	Rieske (2fe-2S)
DKE45_RS12435	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE45_RS12445	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS12485	COG1643	Atp-dependent helicase
DKE45_RS12515	COG3634	alkyl hydroperoxide reductase activity
DKE45_RS12535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE45_RS12540	COG0625	glutathione transferase activity
DKE45_RS12550	COG2885	chlorophyll binding
DKE45_RS12605	COG1765	OsmC-like protein
DKE45_RS12635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE45_RS12655	COG0582	viral genome integration into host DNA
DKE45_RS12670	COG3293	Transposase
DKE45_RS12745	COG1598	PFAM Uncharacterised protein family UPF0150
DKE45_RS12940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DKE45_RS12950	COG3038	cytochrome b561
DKE45_RS12955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DKE45_RS12970	COG1741	Belongs to the pirin family
DKE45_RS13015	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE45_RS13090	COG2826	transposase and inactivated derivatives, IS30 family
DKE45_RS13180	COG4948	Mandelate Racemase Muconate Lactonizing
DKE45_RS13190	COG2721	sulfolactate sulfo-lyase activity
DKE45_RS13195	COG0697	spore germination
DKE45_RS13300	COG2801	Transposase and inactivated derivatives
DKE45_RS13310	COG4269	membrane
DKE45_RS13360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE45_RS13390	COG4239	(ABC) transporter, permease
DKE45_RS13455	COG1279	arginine transmembrane transporter activity
DKE45_RS13475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE45_RS13555	COG2878	Part of a membrane complex involved in electron transport
DKE45_RS13560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKE45_RS13615	COG0804	urea catabolic process
DKE45_RS13645	COG3015	lipoprotein NlpE involved in copper resistance
DKE45_RS13660	COG1253	flavin adenine dinucleotide binding
DKE45_RS13715	COG1773	rubredoxin
DKE45_RS13725	COG2267	carboxylic ester hydrolase activity
DKE45_RS13730	COG0583	DNA-binding transcription factor activity
DKE45_RS13810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE45_RS13860	COG2223	nitrite transmembrane transporter activity
DKE45_RS13870	COG2066	Belongs to the glutaminase family
DKE45_RS13875	COG0242	peptide deformylase activity
DKE45_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS13960	COG1414	Transcriptional regulator
DKE45_RS13985	COG1215	transferase activity, transferring glycosyl groups
DKE45_RS14020	COG1607	acyl-coa hydrolase
DKE45_RS14135	COG1595	DNA-templated transcription, initiation
DKE45_RS14145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE45_RS14260	COG2050	protein possibly involved in aromatic compounds catabolism
DKE45_RS14320	COG0735	belongs to the Fur family
DKE45_RS14325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE45_RS14350	COG0121	glutamine amidotransferase
DKE45_RS14400	COG2894	cell division
DKE45_RS14430	COG0492	ferredoxin-NADP+ reductase activity
DKE45_RS14435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DKE45_RS14445	COG0456	acetyltransferase
DKE45_RS14460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE45_RS14465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DKE45_RS14475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DKE45_RS14490	COG1981	membrane
DKE45_RS14525	COG4638	Rieske (2fe-2S)
DKE45_RS14545	COG0583	DNA-binding transcription factor activity
DKE45_RS14565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE45_RS14675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE45_RS14685	COG0351	phosphomethylpyrimidine kinase
DKE45_RS14685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE45_RS14685	COG0352	thiamine-phosphate diphosphorylase activity
DKE45_RS14730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DKE45_RS14735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE45_RS14750	COG4106	trans-aconitate 2-methyltransferase activity
DKE45_RS14835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE45_RS14885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE45_RS14940	COG2081	HI0933 family
DKE45_RS14950	COG0668	transmembrane transport
DKE45_RS14990	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKE45_RS14995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKE45_RS15025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DKE45_RS15065	COG0745	RESPONSE REGULATOR receiver
DKE45_RS15080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKE45_RS15160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE45_RS15175	COG0583	DNA-binding transcription factor activity
DKE45_RS15225	COG0583	DNA-binding transcription factor activity
DKE45_RS15260	COG1063	alcohol dehydrogenase
DKE45_RS15295	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DKE45_RS15300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKE45_RS15305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE45_RS15340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE45_RS15365	COG1214	PFAM Peptidase M22, glycoprotease
DKE45_RS15425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE45_RS15430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE45_RS15435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DKE45_RS15495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE45_RS15505	COG1846	Transcriptional regulator
DKE45_RS15510	COG1764	response to oxidative stress
DKE45_RS15560	COG0248	Ppx GppA phosphatase
DKE45_RS15615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE45_RS15635	COG0625	glutathione transferase activity
DKE45_RS15655	COG0318	PFAM AMP-dependent synthetase and ligase
DKE45_RS15665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE45_RS15740	COG2084	Dehydrogenase
DKE45_RS15745	COG3622	Belongs to the hyi family
DKE45_RS15785	COG2814	Major facilitator Superfamily
DKE45_RS15830	COG0492	ferredoxin-NADP+ reductase activity
DKE45_RS15835	COG0431	NADPH-dependent FMN reductase
DKE45_RS15850	COG0640	Transcriptional regulator
DKE45_RS15900	COG3328	transposase activity
DKE45_RS15930	COG2205	protein histidine kinase activity
DKE45_RS16025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE45_RS16100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKE45_RS16105	COG0440	acetolactate synthase activity
DKE45_RS16130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE45_RS16170	COG1162	GTPase activity
DKE45_RS16180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE45_RS16200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKE45_RS16285	COG3265	gluconokinase activity
DKE45_RS16370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE45_RS16370	COG2813	Specifically methylates the guanine in position
DKE45_RS16470	COG0788	formyltetrahydrofolate deformylase activity
DKE45_RS16495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKE45_RS16495	COG4651	solute:proton antiporter activity
DKE45_RS16515	COG0724	RNA recognition motif
DKE45_RS16545	COG1733	regulation of RNA biosynthetic process
DKE45_RS16555	COG2900	Belongs to the SlyX family
DKE45_RS16570	COG1560	Kdo2-lipid A biosynthetic process
DKE45_RS16580	COG1301	dicarboxylic acid transport
DKE45_RS16700	COG0583	DNA-binding transcription factor activity
DKE45_RS16715	COG2378	regulation of single-species biofilm formation
DKE45_RS16720	COG0546	phosphoglycolate phosphatase activity
DKE45_RS16755	COG0583	DNA-binding transcription factor activity
DKE45_RS16765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKE45_RS16790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKE45_RS16815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE45_RS16815	COG0493	'glutamate synthase
DKE45_RS16825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE45_RS16830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE45_RS16845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE45_RS16870	COG4535	Mg2 and Co2 transporter CorC
DKE45_RS16910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE45_RS16925	COG0789	Transcriptional regulator
DKE45_RS16930	COG0598	Magnesium transport protein CorA
DKE45_RS16935	COG1185	polyribonucleotide nucleotidyltransferase activity
DKE45_RS16950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE45_RS16980	COG2226	methyltransferase
DKE45_RS17035	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE45_RS17050	COG2212	antiporter activity
DKE45_RS17060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE45_RS17130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE45_RS17145	COG0497	DNA recombination
DKE45_RS17195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE45_RS17270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DKE45_RS17300	COG2056	Na+-H+ antiporter family
DKE45_RS17370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE45_RS17400	COG0546	phosphoglycolate phosphatase activity
DKE45_RS17405	COG1716	ATPase activity
DKE45_RS17490	COG0697	spore germination
DKE45_RS17510	COG0494	nUDIX hydrolase
DKE45_RS17515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKE45_RS17555	COG4974	Belongs to the 'phage' integrase family
DKE45_RS17570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE45_RS17580	COG2197	response regulator
DKE45_RS17600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DKE45_RS17660	COG0347	Belongs to the P(II) protein family
DKE45_RS17670	COG0606	chelatase, subunit chli
DKE45_RS17690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE45_RS17710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DKE45_RS17735	COG0477	Major facilitator Superfamily
DKE45_RS17740	COG2860	membrane
DKE45_RS17750	COG1253	flavin adenine dinucleotide binding
DKE45_RS17770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE45_RS17810	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE45_RS17825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE45_RS17900	COG0697	spore germination
DKE45_RS17935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE45_RS17945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DKE45_RS17985	COG1121	(ABC) transporter
DKE45_RS17990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE45_RS18000	COG2837	iron assimilation
DKE45_RS18065	COG2259	Doxx family
DKE45_RS18095	COG0271	Belongs to the BolA IbaG family
DKE45_RS18125	COG3321	synthase
DKE45_RS18125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE45_RS18125	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DKE45_RS18125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKE45_RS18150	COG3916	Acyl-homoserine-lactone synthase
DKE45_RS18170	COG1113	amino acid transport
DKE45_RS18190	COG1024	Enoyl-CoA hydratase
DKE45_RS18195	COG1960	acyl-CoA dehydrogenase activity
DKE45_RS18200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE45_RS18235	COG0251	oxidation-reduction process
DKE45_RS18275	COG0564	pseudouridine synthase activity
DKE45_RS18370	COG1802	Transcriptional regulator
DKE45_RS18385	COG0277	FAD linked oxidase domain protein
DKE45_RS18420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DKE45_RS18425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKE45_RS18465	COG1091	dTDP-4-dehydrorhamnose reductase activity
DKE45_RS18580	COG0546	phosphoglycolate phosphatase activity
DKE45_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
DKE45_RS18600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DKE45_RS18600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DKE45_RS18615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE45_RS18620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE45_RS18630	COG1309	transcriptional regulator
DKE45_RS18645	COG0196	riboflavin kinase activity
DKE45_RS18660	COG1047	Peptidyl-prolyl cis-trans
DKE45_RS18700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE45_RS18775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE45_RS18790	COG0861	Integral membrane protein TerC family
DKE45_RS18825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKE45_RS18880	COG2801	Transposase and inactivated derivatives
DKE45_RS18895	COG1192	Involved in chromosome partitioning
DKE45_RS19135	COG2801	Transposase and inactivated derivatives
DKE45_RS19220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DKE45_RS19280	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE45_RS19285	COG0488	(ABC) transporter
DKE45_RS19325	COG1538	Outer membrane efflux protein
DKE45_RS19490	COG0789	Transcriptional regulator
DKE45_RS19515	COG0789	Transcriptional regulator
DKE45_RS19590	COG0583	DNA-binding transcription factor activity
DKE45_RS19615	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKE45_RS19645	COG0251	oxidation-reduction process
DKE45_RS19660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE45_RS19670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE45_RS19675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE45_RS19740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DKE45_RS19780	COG0517	IMP dehydrogenase activity
DKE45_RS19780	COG0617	tRNA 3'-terminal CCA addition
DKE45_RS19780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DKE45_RS19915	COG1525	nuclease
DKE45_RS20065	COG1484	DNA-dependent DNA replication
DKE45_RS20255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE45_RS20295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE45_RS20325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE45_RS20330	COG0625	glutathione transferase activity
DKE45_RS20370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DKE45_RS20380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE45_RS20400	COG2009	succinate dehydrogenase
DKE45_RS20660	COG3321	synthase
DKE45_RS20660	COG0604	alcohol dehydrogenase
DKE45_RS20970	COG0604	alcohol dehydrogenase