locus-tag	class	description
DKE46_RS00010	COG0592	DNA-directed DNA polymerase activity
DKE46_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKE46_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKE46_RS00155	COG2233	PERMEase
DKE46_RS00205	COG2814	Major facilitator Superfamily
DKE46_RS00210	COG0656	L-ascorbic acid biosynthetic process
DKE46_RS00270	COG5487	UPF0391 membrane protein
DKE46_RS00275	COG2983	Belongs to the UPF0260 family
DKE46_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE46_RS00330	COG1683	Conserved Protein
DKE46_RS00670	COG2233	PERMEase
DKE46_RS00675	COG2351	hydroxyisourate hydrolase activity
DKE46_RS00710	COG3706	GGDEF domain
DKE46_RS00730	COG0708	Exodeoxyribonuclease III
DKE46_RS00770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKE46_RS00795	COG4942	peptidase
DKE46_RS00825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE46_RS00825	COG0426	domain, Protein
DKE46_RS00865	COG1902	pentaerythritol trinitrate reductase activity
DKE46_RS00875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKE46_RS00900	COG1522	sequence-specific DNA binding
DKE46_RS00905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE46_RS00930	COG3162	membrane
DKE46_RS00970	COG1309	transcriptional regulator
DKE46_RS01000	COG0352	thiamine-phosphate diphosphorylase activity
DKE46_RS01000	COG0351	phosphomethylpyrimidine kinase
DKE46_RS01000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE46_RS01010	COG2814	Major facilitator Superfamily
DKE46_RS01090	COG0641	radical SAM
DKE46_RS01120	COG1113	amino acid transport
DKE46_RS01135	COG1012	belongs to the aldehyde dehydrogenase family
DKE46_RS01145	COG1335	isochorismatase
DKE46_RS01240	COG0583	DNA-binding transcription factor activity
DKE46_RS01345	COG2826	transposase and inactivated derivatives, IS30 family
DKE46_RS01400	COG2814	Major facilitator Superfamily
DKE46_RS01495	COG0582	viral genome integration into host DNA
DKE46_RS01560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE46_RS01575	COG0697	spore germination
DKE46_RS01600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE46_RS01630	COG0427	acetyl-CoA hydrolase
DKE46_RS01660	COG4221	oxidoreductase activity
DKE46_RS01805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKE46_RS01885	COG1704	LemA family
DKE46_RS01900	COG4969	Belongs to the N-Me-Phe pilin family
DKE46_RS01950	COG0194	GDP metabolic process
DKE46_RS02000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE46_RS02020	COG5380	lipid catabolic process
DKE46_RS02040	COG5006	permease, DMT superfamily
DKE46_RS02055	COG0277	FAD linked oxidase domain protein
DKE46_RS02065	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE46_RS02135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE46_RS02140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE46_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
DKE46_RS02215	COG0752	glycyl-tRNA synthetase alpha subunit
DKE46_RS02245	COG1983	PspC domain protein
DKE46_RS02255	COG1960	acyl-CoA dehydrogenase activity
DKE46_RS02315	COG2854	intermembrane phospholipid transfer
DKE46_RS02335	COG0494	nUDIX hydrolase
DKE46_RS02385	COG1959	2 iron, 2 sulfur cluster binding
DKE46_RS02390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE46_RS02390	COG1017	nitric oxide dioxygenase activity
DKE46_RS02405	COG0626	cystathionine gamma-synthase activity
DKE46_RS02420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE46_RS02425	COG0088	Forms part of the polypeptide exit tunnel
DKE46_RS02560	COG1960	acyl-CoA dehydrogenase activity
DKE46_RS02565	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKE46_RS02655	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE46_RS02660	COG1295	ribonuclease BN
DKE46_RS02705	COG0739	heme binding
DKE46_RS02705	COG0741	lytic transglycosylase activity
DKE46_RS02705	COG1196	nuclear chromosome segregation
DKE46_RS02735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DKE46_RS02740	COG1183	phosphatidylcholine synthase activity
DKE46_RS02790	COG1309	transcriptional regulator
DKE46_RS02850	COG2969	positive regulation of protein catabolic process
DKE46_RS02855	COG0625	glutathione transferase activity
DKE46_RS02860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE46_RS02870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKE46_RS02915	COG1408	metallophosphoesterase
DKE46_RS02995	COG1607	acyl-coa hydrolase
DKE46_RS03055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE46_RS03070	COG1862	Preprotein translocase
DKE46_RS03130	COG0726	polysaccharide deacetylase
DKE46_RS03195	COG0625	glutathione transferase activity
DKE46_RS03200	COG0583	DNA-binding transcription factor activity
DKE46_RS03205	COG1960	acyl-CoA dehydrogenase activity
DKE46_RS03255	COG2096	Adenosyltransferase
DKE46_RS03345	COG0477	Major facilitator Superfamily
DKE46_RS03350	COG1272	protein, Hemolysin III
DKE46_RS03360	COG2153	protein acetylation
DKE46_RS03385	COG2207	Transcriptional regulator
DKE46_RS03405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE46_RS03435	COG2885	chlorophyll binding
DKE46_RS03435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DKE46_RS03455	COG2233	PERMEase
DKE46_RS03460	COG1217	gtp-binding protein TYPA
DKE46_RS03485	COG2094	Belongs to the DNA glycosylase MPG family
DKE46_RS03495	COG1902	pentaerythritol trinitrate reductase activity
DKE46_RS03510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKE46_RS03540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE46_RS03545	COG0251	oxidation-reduction process
DKE46_RS03550	COG1335	isochorismatase
DKE46_RS03555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE46_RS03560	COG0778	Nitroreductase
DKE46_RS03565	COG0596	Alpha beta hydrolase
DKE46_RS03570	COG3189	MarR family transcriptional regulator
DKE46_RS03580	COG3422	double-strand break repair
DKE46_RS03640	COG5510	response to toxic substance
DKE46_RS03650	COG2832	Protein of unknown function (DUF454)
DKE46_RS03745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKE46_RS03790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE46_RS03800	COG1792	Involved in formation and maintenance of cell shape
DKE46_RS03805	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DKE46_RS03825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE46_RS03870	COG2207	Transcriptional regulator
DKE46_RS03900	COG3046	protein related to deoxyribodipyrimidine photolyase
DKE46_RS03925	COG2315	Protein conserved in bacteria
DKE46_RS03950	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE46_RS04000	COG0004	ammonium transporteR
DKE46_RS04005	COG0583	DNA-binding transcription factor activity
DKE46_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS04120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE46_RS04175	COG2921	Belongs to the UPF0250 family
DKE46_RS04215	COG2009	succinate dehydrogenase
DKE46_RS04220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DKE46_RS04225	COG1053	succinate dehydrogenase
DKE46_RS04230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE46_RS04280	COG2321	neutral zinc metallopeptidase
DKE46_RS04350	COG0589	response to stress
DKE46_RS04365	COG1309	transcriptional regulator
DKE46_RS04380	COG0505	Belongs to the CarA family
DKE46_RS04490	COG1597	lipid kinase activity
DKE46_RS04685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE46_RS04715	COG0584	glycerophosphoryl diester phosphodiesterase
DKE46_RS04735	COG0741	lytic transglycosylase activity
DKE46_RS04835	COG0243	molybdopterin cofactor binding
DKE46_RS04840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE46_RS04845	COG3339	Conserved Protein
DKE46_RS04965	COG1136	(ABC) transporter
DKE46_RS04995	COG0596	Alpha beta hydrolase
DKE46_RS05000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE46_RS05010	COG0628	permease
DKE46_RS05050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE46_RS05070	COG0823	Involved in the tonB-independent uptake of proteins
DKE46_RS05090	COG0824	Thioesterase
DKE46_RS05120	COG2814	Major facilitator Superfamily
DKE46_RS05135	COG1051	belongs to the nudix hydrolase family
DKE46_RS05135	COG1056	cytidyltransferase-related domain
DKE46_RS05150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DKE46_RS05165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE46_RS05180	COG4625	pathogenesis
DKE46_RS05190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKE46_RS05200	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DKE46_RS05250	COG0481	GTPase activity
DKE46_RS05255	COG0681	Belongs to the peptidase S26 family
DKE46_RS05265	COG0571	ribonuclease III activity
DKE46_RS05295	COG4221	oxidoreductase activity
DKE46_RS05345	COG0556	nucleotide-excision repair
DKE46_RS05410	COG2070	2-Nitropropane dioxygenase
DKE46_RS05425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE46_RS05455	COG0415	Belongs to the DNA photolyase family
DKE46_RS05470	COG1686	Belongs to the peptidase S11 family
DKE46_RS05510	COG1823	symporter activity
DKE46_RS05545	COG0352	thiamine-phosphate diphosphorylase activity
DKE46_RS05610	COG1522	sequence-specific DNA binding
DKE46_RS05625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKE46_RS05630	COG0573	inorganic phosphate transmembrane transporter activity
DKE46_RS05680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE46_RS05710	COG0583	DNA-binding transcription factor activity
DKE46_RS05755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKE46_RS05760	COG1966	Carbon starvation protein
DKE46_RS05765	COG2879	small protein
DKE46_RS05900	COG1741	Belongs to the pirin family
DKE46_RS05930	COG4604	ABC transporter, ATP-binding protein
DKE46_RS05960	COG1535	isochorismatase
DKE46_RS05960	COG3433	isochorismatase activity
DKE46_RS05980	COG1132	(ABC) transporter
DKE46_RS05985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DKE46_RS06110	COG0174	glutamine synthetase
DKE46_RS06120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DKE46_RS06155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE46_RS06160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE46_RS06165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKE46_RS06190	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE46_RS06215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE46_RS06220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE46_RS06240	COG0024	Methionine aminopeptidase
DKE46_RS06245	COG0052	Belongs to the universal ribosomal protein uS2 family
DKE46_RS06285	COG2951	lytic endotransglycosylase activity
DKE46_RS06355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE46_RS06370	COG4215	(ABC) transporter
DKE46_RS06375	COG4160	amino acid transport
DKE46_RS06390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE46_RS06395	COG0826	peptidase U32
DKE46_RS06405	COG0384	phenazine biosynthesis protein PhzF
DKE46_RS06415	COG1720	tRNA m6t6A37 methyltransferase activity
DKE46_RS06450	COG0494	nUDIX hydrolase
DKE46_RS06460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKE46_RS06465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE46_RS06470	COG3139	Protein of unknown function (DUF1315)
DKE46_RS06475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKE46_RS06485	COG1301	dicarboxylic acid transport
DKE46_RS06515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE46_RS06605	COG1278	Cold shock
DKE46_RS06610	COG0513	Belongs to the DEAD box helicase family
DKE46_RS06620	COG0778	Nitroreductase
DKE46_RS06650	COG1286	toxin biosynthetic process
DKE46_RS06680	COG1610	YqeY-like protein
DKE46_RS06820	COG1309	transcriptional regulator
DKE46_RS06860	COG2351	hydroxyisourate hydrolase activity
DKE46_RS06985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE46_RS06990	COG2011	ABC-type metal ion transport system permease component
DKE46_RS07015	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DKE46_RS07055	COG1305	Transglutaminase-like
DKE46_RS07065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE46_RS07095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE46_RS07105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE46_RS07145	COG3658	cytochrome
DKE46_RS07170	COG0583	DNA-binding transcription factor activity
DKE46_RS07190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE46_RS07215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE46_RS07230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKE46_RS07260	COG0745	RESPONSE REGULATOR receiver
DKE46_RS07380	COG1187	pseudouridine synthase activity
DKE46_RS07400	COG0802	atpase or kinase
DKE46_RS07415	COG1923	regulation of RNA biosynthetic process
DKE46_RS07445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKE46_RS07590	COG4772	TonB-dependent receptor
DKE46_RS07665	COG1733	regulation of RNA biosynthetic process
DKE46_RS07700	COG0583	DNA-binding transcription factor activity
DKE46_RS07715	COG2826	transposase and inactivated derivatives, IS30 family
DKE46_RS07765	COG3135	benzoate transporter
DKE46_RS07770	COG1522	sequence-specific DNA binding
DKE46_RS07870	COG1335	isochorismatase
DKE46_RS07920	COG0069	glutamate synthase activity
DKE46_RS07965	COG0511	ligase activity, forming carbon-carbon bonds
DKE46_RS08005	COG2423	ornithine cyclodeaminase activity
DKE46_RS08040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE46_RS08065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKE46_RS08080	COG0315	cyclic pyranopterin monophosphate synthase activity
DKE46_RS08080	COG0521	Mo-molybdopterin cofactor biosynthetic process
DKE46_RS08095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE46_RS08125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE46_RS08200	COG3852	Histidine kinase
DKE46_RS08265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE46_RS08290	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DKE46_RS08295	COG1011	Hydrolase
DKE46_RS08310	COG1522	sequence-specific DNA binding
DKE46_RS08415	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DKE46_RS08450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKE46_RS08455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE46_RS08510	COG4890	Cyd operon protein YbgT
DKE46_RS08515	COG1294	oxidase, subunit
DKE46_RS08560	COG0569	domain protein
DKE46_RS08595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKE46_RS08610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE46_RS08665	COG0148	phosphopyruvate hydratase activity
DKE46_RS08685	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE46_RS08695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE46_RS08705	COG0183	Belongs to the thiolase family
DKE46_RS08710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DKE46_RS08715	COG0596	Alpha beta hydrolase
DKE46_RS08720	COG2271	Major facilitator Superfamily
DKE46_RS08725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE46_RS08735	COG3485	protocatechuate 3,4-dioxygenase
DKE46_RS08765	COG2391	methyltransferase activity
DKE46_RS08780	COG1414	Transcriptional regulator
DKE46_RS08875	COG3733	amine oxidase
DKE46_RS08895	COG0183	Belongs to the thiolase family
DKE46_RS08920	COG4829	muconolactone delta-isomerase
DKE46_RS08925	COG4948	Mandelate Racemase Muconate Lactonizing
DKE46_RS08940	COG2186	Transcriptional regulator
DKE46_RS08965	COG2351	hydroxyisourate hydrolase activity
DKE46_RS08985	COG2186	Transcriptional regulator
DKE46_RS09070	COG1309	transcriptional regulator
DKE46_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS09110	COG0318	PFAM AMP-dependent synthetase and ligase
DKE46_RS09235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE46_RS09240	COG1120	ATPase activity
DKE46_RS09250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE46_RS09325	COG4628	conserved protein (DUF2132)
DKE46_RS09340	COG3539	Fimbrial protein
DKE46_RS09365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKE46_RS09375	COG0753	catalase activity
DKE46_RS09410	COG0745	RESPONSE REGULATOR receiver
DKE46_RS09415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE46_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS09490	COG4149	molybdate abc transporter
DKE46_RS09515	COG0543	2 iron, 2 sulfur cluster binding
DKE46_RS09515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE46_RS09530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE46_RS09560	COG2207	Transcriptional regulator
DKE46_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS09630	COG0183	Belongs to the thiolase family
DKE46_RS09635	COG0583	DNA-binding transcription factor activity
DKE46_RS09655	COG1027	Aspartate ammonia-lyase
DKE46_RS09665	COG0477	Major facilitator Superfamily
DKE46_RS09685	COG3708	Transcriptional regulator
DKE46_RS09685	COG2207	Transcriptional regulator
DKE46_RS09710	COG0730	response to heat
DKE46_RS09755	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE46_RS09760	COG0022	dehydrogenase e1 component
DKE46_RS09765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE46_RS09770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE46_RS09815	COG0133	tryptophan synthase activity
DKE46_RS09860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKE46_RS09875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DKE46_RS09940	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKE46_RS09970	COG0730	response to heat
DKE46_RS09975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKE46_RS09995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DKE46_RS10045	COG1960	acyl-CoA dehydrogenase activity
DKE46_RS10055	COG2207	Transcriptional regulator
DKE46_RS10065	COG0776	regulation of translation
DKE46_RS10365	COG1663	tetraacyldisaccharide 4'-kinase activity
DKE46_RS10370	COG1132	(ABC) transporter
DKE46_RS10390	COG1192	Involved in chromosome partitioning
DKE46_RS10415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKE46_RS10455	COG0640	Transcriptional regulator
DKE46_RS10500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE46_RS10515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE46_RS10595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DKE46_RS10595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DKE46_RS10625	COG3539	Fimbrial protein
DKE46_RS10660	COG0583	DNA-binding transcription factor activity
DKE46_RS10725	COG1522	sequence-specific DNA binding
DKE46_RS10735	COG1126	abc transporter atp-binding protein
DKE46_RS10740	COG0765	amino acid transport
DKE46_RS10745	COG0765	amino acid transport
DKE46_RS10775	COG1464	Belongs to the NlpA lipoprotein family
DKE46_RS10785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE46_RS10795	COG0012	GTP binding
DKE46_RS10820	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DKE46_RS10875	COG1301	dicarboxylic acid transport
DKE46_RS10910	COG3634	alkyl hydroperoxide reductase activity
DKE46_RS10930	COG0431	NADPH-dependent FMN reductase
DKE46_RS10945	COG0640	Transcriptional regulator
DKE46_RS11035	COG1271	oxidase subunit
DKE46_RS11040	COG1294	oxidase, subunit
DKE46_RS11130	COG0583	DNA-binding transcription factor activity
DKE46_RS11140	COG0625	glutathione transferase activity
DKE46_RS11180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKE46_RS11220	COG0765	amino acid transport
DKE46_RS11225	COG0765	amino acid transport
DKE46_RS11275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE46_RS11380	COG4770	biotin carboxylase activity
DKE46_RS11425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE46_RS11430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE46_RS11435	COG2814	Major facilitator Superfamily
DKE46_RS11450	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS11500	COG2814	Major facilitator Superfamily
DKE46_RS11510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DKE46_RS11545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKE46_RS11550	COG1414	Transcriptional regulator
DKE46_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS11600	COG2050	protein possibly involved in aromatic compounds catabolism
DKE46_RS11610	COG3327	negative regulation of DNA-templated transcription, initiation
DKE46_RS11630	COG1024	Enoyl-CoA hydratase
DKE46_RS11635	COG1024	Enoyl-CoA hydratase
DKE46_RS11645	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE46_RS11650	COG3396	Phenylacetate-CoA oxygenase
DKE46_RS11655	COG3460	Phenylacetate-CoA oxygenase
DKE46_RS11660	COG3396	Phenylacetate-CoA oxygenase
DKE46_RS11690	COG0789	Transcriptional regulator
DKE46_RS11700	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKE46_RS11725	COG0590	tRNA wobble adenosine to inosine editing
DKE46_RS11770	COG1063	alcohol dehydrogenase
DKE46_RS11775	COG1063	alcohol dehydrogenase
DKE46_RS11855	COG4770	biotin carboxylase activity
DKE46_RS11890	COG1595	DNA-templated transcription, initiation
DKE46_RS11965	COG0702	epimerase
DKE46_RS12060	COG3038	cytochrome b561
DKE46_RS12070	COG1733	regulation of RNA biosynthetic process
DKE46_RS12100	COG0531	amino acid
DKE46_RS12135	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DKE46_RS12175	COG1538	Outer membrane efflux protein
DKE46_RS12190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKE46_RS12260	COG0668	transmembrane transport
DKE46_RS12325	COG2226	methyltransferase
DKE46_RS12350	COG1278	Cold shock
DKE46_RS12360	COG1280	lysine exporter protein (LysE YggA)
DKE46_RS12485	COG2871	sodium ion transport
DKE46_RS12505	COG4638	Rieske (2fe-2S)
DKE46_RS12510	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DKE46_RS12515	COG0543	2 iron, 2 sulfur cluster binding
DKE46_RS12515	COG0633	Ferredoxin
DKE46_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS12570	COG3634	alkyl hydroperoxide reductase activity
DKE46_RS12590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE46_RS12595	COG0625	glutathione transferase activity
DKE46_RS12655	COG1765	OsmC-like protein
DKE46_RS12695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DKE46_RS12705	COG0582	viral genome integration into host DNA
DKE46_RS12725	COG3293	Transposase
DKE46_RS12765	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DKE46_RS12770	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DKE46_RS12820	COG1598	PFAM Uncharacterised protein family UPF0150
DKE46_RS12975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DKE46_RS13005	COG1741	Belongs to the pirin family
DKE46_RS13010	COG1309	transcriptional regulator
DKE46_RS13215	COG4948	Mandelate Racemase Muconate Lactonizing
DKE46_RS13230	COG0697	spore germination
DKE46_RS13335	COG2801	Transposase and inactivated derivatives
DKE46_RS13405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE46_RS13440	COG4174	ABC transporter (Permease)
DKE46_RS13585	COG3384	dioxygenase
DKE46_RS13600	COG2878	Part of a membrane complex involved in electron transport
DKE46_RS13605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKE46_RS13635	COG0742	ribosomal rna small subunit methyltransferase
DKE46_RS13650	COG0830	nickel cation binding
DKE46_RS13685	COG3015	lipoprotein NlpE involved in copper resistance
DKE46_RS13755	COG1773	rubredoxin
DKE46_RS13770	COG0583	DNA-binding transcription factor activity
DKE46_RS13870	COG0306	phosphate transporter
DKE46_RS13895	COG2271	Major facilitator Superfamily
DKE46_RS13925	COG2223	nitrite transmembrane transporter activity
DKE46_RS13930	COG0662	Cupin 2, conserved barrel domain protein
DKE46_RS13930	COG2207	Transcriptional regulator
DKE46_RS13935	COG2066	Belongs to the glutaminase family
DKE46_RS13940	COG0242	peptide deformylase activity
DKE46_RS13975	COG2267	carboxylic ester hydrolase activity
DKE46_RS13985	COG2271	Major facilitator Superfamily
DKE46_RS14035	COG1024	Enoyl-CoA hydratase
DKE46_RS14045	COG1215	transferase activity, transferring glycosyl groups
DKE46_RS14060	COG4681	YaeQ
DKE46_RS14080	COG1607	acyl-coa hydrolase
DKE46_RS14100	COG1309	transcriptional regulator
DKE46_RS14275	COG2814	Major facilitator Superfamily
DKE46_RS14285	COG2050	protein possibly involved in aromatic compounds catabolism
DKE46_RS14355	COG0735	belongs to the Fur family
DKE46_RS14385	COG0121	glutamine amidotransferase
DKE46_RS14415	COG2885	chlorophyll binding
DKE46_RS14435	COG2894	cell division
DKE46_RS14460	COG0492	ferredoxin-NADP+ reductase activity
DKE46_RS14475	COG0456	acetyltransferase
DKE46_RS14490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE46_RS14495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DKE46_RS14520	COG1981	membrane
DKE46_RS14570	COG0473	3-isopropylmalate dehydrogenase activity
DKE46_RS14575	COG0583	DNA-binding transcription factor activity
DKE46_RS14595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKE46_RS14645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DKE46_RS14715	COG0351	phosphomethylpyrimidine kinase
DKE46_RS14715	COG0352	thiamine-phosphate diphosphorylase activity
DKE46_RS14715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE46_RS14720	COG1652	LysM domain
DKE46_RS14750	COG3101	peptidyl-lysine hydroxylation
DKE46_RS14755	COG0009	L-threonylcarbamoyladenylate synthase
DKE46_RS14760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DKE46_RS14765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE46_RS14780	COG4106	trans-aconitate 2-methyltransferase activity
DKE46_RS14805	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DKE46_RS14810	COG2223	nitrite transmembrane transporter activity
DKE46_RS14830	COG1196	nuclear chromosome segregation
DKE46_RS14865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE46_RS14985	COG0668	transmembrane transport
DKE46_RS15025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKE46_RS15030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKE46_RS15100	COG0745	RESPONSE REGULATOR receiver
DKE46_RS15115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKE46_RS15170	COG0438	transferase activity, transferring glycosyl groups
DKE46_RS15245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE46_RS15295	COG0583	DNA-binding transcription factor activity
DKE46_RS15315	COG0583	DNA-binding transcription factor activity
DKE46_RS15385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DKE46_RS15425	COG0561	phosphatase activity
DKE46_RS15430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE46_RS15440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DKE46_RS15455	COG1214	PFAM Peptidase M22, glycoprotease
DKE46_RS15520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE46_RS15525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE46_RS15530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DKE46_RS15605	COG1764	response to oxidative stress
DKE46_RS15705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE46_RS15725	COG0625	glutathione transferase activity
DKE46_RS15755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE46_RS15825	COG1024	Enoyl-CoA hydratase
DKE46_RS15830	COG2084	Dehydrogenase
DKE46_RS15915	COG0492	ferredoxin-NADP+ reductase activity
DKE46_RS15920	COG0431	NADPH-dependent FMN reductase
DKE46_RS15925	COG0798	PFAM Bile acid sodium symporter
DKE46_RS15935	COG0640	Transcriptional regulator
DKE46_RS16090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE46_RS16170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKE46_RS16175	COG0440	acetolactate synthase activity
DKE46_RS16180	COG0028	Belongs to the TPP enzyme family
DKE46_RS16200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE46_RS16235	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DKE46_RS16250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE46_RS16290	COG1426	Protein conserved in bacteria
DKE46_RS16325	COG0793	Belongs to the peptidase S41A family
DKE46_RS16340	COG2267	carboxylic ester hydrolase activity
DKE46_RS16350	COG1012	belongs to the aldehyde dehydrogenase family
DKE46_RS16355	COG3265	gluconokinase activity
DKE46_RS16380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKE46_RS16390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE46_RS16390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DKE46_RS16440	COG2813	Specifically methylates the guanine in position
DKE46_RS16440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKE46_RS16540	COG0788	formyltetrahydrofolate deformylase activity
DKE46_RS16595	COG0724	RNA recognition motif
DKE46_RS16625	COG1733	regulation of RNA biosynthetic process
DKE46_RS16630	COG0604	alcohol dehydrogenase
DKE46_RS16635	COG2900	Belongs to the SlyX family
DKE46_RS16655	COG1560	Kdo2-lipid A biosynthetic process
DKE46_RS16790	COG0583	DNA-binding transcription factor activity
DKE46_RS16805	COG0625	glutathione transferase activity
DKE46_RS16815	COG0546	phosphoglycolate phosphatase activity
DKE46_RS16850	COG0583	DNA-binding transcription factor activity
DKE46_RS16920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKE46_RS16925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE46_RS16940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE46_RS16965	COG4535	Mg2 and Co2 transporter CorC
DKE46_RS16975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE46_RS17005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE46_RS17020	COG0789	Transcriptional regulator
DKE46_RS17025	COG0598	Magnesium transport protein CorA
DKE46_RS17030	COG1185	polyribonucleotide nucleotidyltransferase activity
DKE46_RS17040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DKE46_RS17045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE46_RS17075	COG2226	methyltransferase
DKE46_RS17130	COG1863	multisubunit Na H antiporter MnhE subunit
DKE46_RS17135	COG2212	antiporter activity
DKE46_RS17145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE46_RS17215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE46_RS17275	COG2169	Transcriptional regulator
DKE46_RS17275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE46_RS17280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE46_RS17380	COG2056	Na+-H+ antiporter family
DKE46_RS17480	COG0546	phosphoglycolate phosphatase activity
DKE46_RS17530	COG0181	hydroxymethylbilane synthase activity
DKE46_RS17570	COG0697	spore germination
DKE46_RS17595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKE46_RS17600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE46_RS17660	COG2197	response regulator
DKE46_RS17740	COG0347	Belongs to the P(II) protein family
DKE46_RS17755	COG0431	NADPH-dependent FMN reductase
DKE46_RS17770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE46_RS17820	COG2860	membrane
DKE46_RS17890	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE46_RS17905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE46_RS17980	COG0697	spore germination
DKE46_RS18015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE46_RS18065	COG1121	(ABC) transporter
DKE46_RS18070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE46_RS18075	COG1280	lysine exporter protein (LysE YggA)
DKE46_RS18130	COG0519	Catalyzes the synthesis of GMP from XMP
DKE46_RS18130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE46_RS18140	COG2259	Doxx family
DKE46_RS18145	COG0586	Pfam SNARE associated Golgi protein
DKE46_RS18170	COG0271	Belongs to the BolA IbaG family
DKE46_RS18215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKE46_RS18215	COG3321	synthase
DKE46_RS18215	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DKE46_RS18215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE46_RS18230	COG2197	response regulator
DKE46_RS18240	COG3916	Acyl-homoserine-lactone synthase
DKE46_RS18260	COG1113	amino acid transport
DKE46_RS18265	COG0697	spore germination
DKE46_RS18275	COG1024	Enoyl-CoA hydratase
DKE46_RS18280	COG1024	Enoyl-CoA hydratase
DKE46_RS18360	COG0564	pseudouridine synthase activity
DKE46_RS18395	COG1051	belongs to the nudix hydrolase family
DKE46_RS18430	COG1802	Transcriptional regulator
DKE46_RS18440	COG1448	Aminotransferase
DKE46_RS18455	COG2186	Transcriptional regulator
DKE46_RS18485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKE46_RS18520	COG1091	dTDP-4-dehydrorhamnose reductase activity
DKE46_RS18550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DKE46_RS18585	COG3023	N-Acetylmuramoyl-L-alanine amidase
DKE46_RS18640	COG0546	phosphoglycolate phosphatase activity
DKE46_RS18645	COG1028	Short-chain dehydrogenase reductase Sdr
DKE46_RS18675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE46_RS18680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE46_RS18720	COG1047	Peptidyl-prolyl cis-trans
DKE46_RS18760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE46_RS18815	COG2951	lytic endotransglycosylase activity
DKE46_RS18820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DKE46_RS18835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE46_RS18850	COG0861	Integral membrane protein TerC family
DKE46_RS19050	COG2009	succinate dehydrogenase
DKE46_RS19070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DKE46_RS19120	COG0625	glutathione transferase activity
DKE46_RS19125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE46_RS19150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE46_RS19295	COG2826	transposase and inactivated derivatives, IS30 family
DKE46_RS19455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DKE46_RS19505	COG1525	nuclease
DKE46_RS19700	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKE46_RS19785	COG0745	RESPONSE REGULATOR receiver
DKE46_RS19820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DKE46_RS19930	COG3173	Aminoglycoside phosphotransferase
DKE46_RS20320	COG1192	Involved in chromosome partitioning
DKE46_RS20390	COG1192	Involved in chromosome partitioning
DKE46_RS20420	COG0604	alcohol dehydrogenase
DKE46_RS20555	COG0604	alcohol dehydrogenase
DKE46_RS20555	COG3321	synthase