locus-tag class description G8E09_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G8E09_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G8E09_RS00035 ENOG4105C5H ABC transporter G8E09_RS00040 ENOG4108821 RND type efflux pump G8E09_RS00045 ENOG4108821 RND type efflux pump G8E09_RS00050 ENOG4108821 RND type efflux pump G8E09_RS00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G8E09_RS00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G8E09_RS00110 ENOG4105C8J )-transporter G8E09_RS00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G8E09_RS00150 ENOG4105C2W permease G8E09_RS00160 ENOG4108IG5 Transcriptional regulator G8E09_RS00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit G8E09_RS00200 ENOG4105F27 Major Facilitator G8E09_RS00205 ENOG4105CV8 reductase G8E09_RS00210 ENOG4105HEI LysR family (Transcriptional regulator G8E09_RS00230 ENOG4105DQ4 alcohol dehydrogenase G8E09_RS00235 ENOG4108R3E Dna-3-methyladenine glycosylase i G8E09_RS00250 ENOG4105CEN a g-specific adenine glycosylase G8E09_RS00270 ENOG4108ZZ3 UPF0260 protein G8E09_RS00275 ENOG4105D8V Glucose sorbosone dehydrogenase G8E09_RS00280 ENOG4105D1H recombination factor protein RarA G8E09_RS00285 ENOG4105S64 Formate nitrite transporter G8E09_RS00305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G8E09_RS00310 ENOG4108RWI nicotinamidase G8E09_RS00315 ENOG4105C09 Bile acid G8E09_RS00320 ENOG4105UQX Mate efflux family protein G8E09_RS00325 ENOG4105EWC Purine nucleoside phosphorylase G8E09_RS00340 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) G8E09_RS00345 ENOG4108RXX maleylacetoacetate isomerase G8E09_RS00355 ENOG4105C85 amino acid G8E09_RS00365 ENOG4105CKI cobalamin synthesis protein G8E09_RS00375 ENOG4105CZE histidine utilization repressor G8E09_RS00380 ENOG41090B9 response to stress G8E09_RS00395 ENOG4105C85 amino acid G8E09_RS00405 ENOG41088SP formiminoglutamate hydrolase G8E09_RS00415 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 G8E09_RS00420 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G8E09_RS00425 ENOG4108NIW Leucine export protein LeuE G8E09_RS00435 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G8E09_RS00445 ENOG4108ZAI phosphatidylglycerophosphatase a G8E09_RS00450 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G8E09_RS00465 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G8E09_RS00505 ENOG4105KHC sulfurtransferase G8E09_RS00535 ENOG4105BZU Histidine kinase G8E09_RS00540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G8E09_RS00555 ENOG4107QJQ Mate efflux family protein G8E09_RS00560 ENOG4105CHM Aminotransferase G8E09_RS00565 ENOG4106BRA Membrane G8E09_RS00580 ENOG4105D9M gamma-glutamylcysteine synthetase G8E09_RS00590 ENOG4105CS6 Rhs element vgr protein G8E09_RS00625 ENOG4105IPS esterase G8E09_RS00630 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G8E09_RS00635 ENOG4108Z2U ureidoglycolate hydrolase G8E09_RS00645 ENOG41061H0 Monooxygenase G8E09_RS00660 ENOG41084YZ Hydrolase G8E09_RS00690 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G8E09_RS00695 ENOG4105BZU Histidine kinase G8E09_RS00710 ENOG4105KUZ arsenate reductase G8E09_RS00715 ENOG4105CGK Exodeoxyribonuclease III G8E09_RS00745 ENOG4105D7Z glutathione synthase G8E09_RS00765 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G8E09_RS00770 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G8E09_RS00775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G8E09_RS00790 ENOG41063SB peptidase G8E09_RS00795 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G8E09_RS00800 ENOG4107QSN dihydrolipoamide acetyltransferase G8E09_RS00815 ENOG4105E0K tonB-dependent siderophore receptor G8E09_RS00825 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G8E09_RS00840 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G8E09_RS00860 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G8E09_RS00865 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G8E09_RS00875 ENOG4105D64 Mechanosensitive ion channel G8E09_RS00885 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G8E09_RS00890 ENOG4108W2Y isochorismatase G8E09_RS00900 ENOG4105FBW Monooxygenase G8E09_RS00905 ENOG4108UZX fmn reductase G8E09_RS00920 ENOG4105BZU Histidine kinase G8E09_RS00925 ENOG41062QD Membrane G8E09_RS00930 ENOG4107QN1 sodium solute G8E09_RS00940 ENOG4105C94 Transporter G8E09_RS00950 ENOG4105BZU Histidine kinase G8E09_RS00955 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G8E09_RS00960 ENOG4108WUH Transcriptional regulator, TetR family G8E09_RS00975 ENOG4105RA2 Membrane G8E09_RS00980 ENOG4108IXY short-chain dehydrogenase reductase G8E09_RS00990 ENOG4105DWF phosphomethylpyrimidine kinase G8E09_RS01000 ENOG4107RDB Major Facilitator G8E09_RS01005 ENOG4108UUM single-stranded DNA-binding protein G8E09_RS01035 ENOG4105D85 methylase G8E09_RS01045 ENOG4105ECI YeeC-like protein G8E09_RS01055 ENOG4105F6A helicase G8E09_RS01060 ENOG4105D85 methylase G8E09_RS01070 ENOG4108UMN azlc family G8E09_RS01090 ENOG4108JPW Aminotransferase G8E09_RS01095 ENOG4105C26 Dehydrogenase G8E09_RS01105 ENOG4105CHJ isochorismatase hydrolase G8E09_RS01110 ENOG4105EUB pirin domain protein G8E09_RS01145 ENOG4105D94 Major Facilitator Superfamily G8E09_RS01150 ENOG4106NZI LysR family Transcriptional regulator G8E09_RS01175 ENOG4105CPC Aldo Keto reductase G8E09_RS01180 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) G8E09_RS01190 ENOG4105R8C Transcriptional regulator G8E09_RS01215 ENOG4105KVH Transcriptional regulator G8E09_RS01220 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G8E09_RS01240 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain G8E09_RS01245 ENOG4108UQN AraC family transcriptional regulator G8E09_RS01305 ENOG4105CUV Homoserine Kinase G8E09_RS01320 ENOG41061CK Antibiotic biosynthesis monooxygenase G8E09_RS01335 ENOG4105BZ1 (ABC) transporter G8E09_RS01345 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) G8E09_RS01355 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G8E09_RS01380 ENOG4108R6G acetyltransferase G8E09_RS01385 ENOG4105CYC Transferase G8E09_RS01395 ENOG4105E0F Histidine kinase G8E09_RS01410 ENOG4105CHH sulfate transporter G8E09_RS01415 ENOG4105PDP Short chain dehydrogenase G8E09_RS01425 ENOG4105VCH membrane G8E09_RS01440 ENOG4105C5H ABC transporter G8E09_RS01520 ENOG4108IQI permease G8E09_RS01545 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G8E09_RS01560 ENOG4105CJN penicillin-binding protein G8E09_RS01565 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G8E09_RS01570 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G8E09_RS01585 ENOG4105DHI Methyltransferase G8E09_RS01590 ENOG4108JQC penicillin-binding protein 1A G8E09_RS01615 ENOG4105E4G Type IV pilus G8E09_RS01635 ENOG4105CBC glutamate synthase G8E09_RS01640 ENOG4105BZ8 glutamate synthase G8E09_RS01650 ENOG4108V0P LemA family G8E09_RS01655 ENOG4105HA9 of methanol dehydrogenase type G8E09_RS01675 ENOG4108YSG O-Antigen polymerase G8E09_RS01680 ENOG4108UQY Iron-storage protein G8E09_RS01690 ENOG4105KME endoribonuclease L-psp G8E09_RS01695 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G8E09_RS01710 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G8E09_RS01760 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G8E09_RS01770 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G8E09_RS01775 ENOG4107IFA Lipase (EC 3.1.1.3) G8E09_RS01780 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) G8E09_RS01785 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G8E09_RS01810 ENOG4108JQ1 Dehydrogenase G8E09_RS01815 ENOG4105CQB FAD linked oxidase domain protein G8E09_RS01835 ENOG4105VRH Antibiotic biosynthesis monooxygenase G8E09_RS01840 ENOG4105NF4 modulator of drug activity G8E09_RS01850 ENOG4107QF7 multi-drug G8E09_RS01855 ENOG4105EM2 membrane G8E09_RS01860 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G8E09_RS01865 ENOG4105IPI Membrane G8E09_RS01870 ENOG4107SKI cobyrinic Acid a,c-diamide synthase G8E09_RS01900 ENOG4108IQI permease G8E09_RS01905 ENOG4105D82 Glutamate dehydrogenase G8E09_RS01910 ENOG4105C8Y Acetylornithine aminotransferase G8E09_RS01920 ENOG4105C26 Dehydrogenase G8E09_RS01985 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit G8E09_RS02010 ENOG4105W87 Cbs domain G8E09_RS02015 ENOG41067S9 phage shock protein C, PspC G8E09_RS02025 ENOG4105CSU acyl-Coa dehydrogenase G8E09_RS02040 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) G8E09_RS02055 ENOG4105ECY inositol monophosphatase G8E09_RS02060 ENOG4105C1J atp-dependent rna helicase G8E09_RS02070 ENOG4105DHJ ABC, transporter G8E09_RS02075 ENOG4105CY3 ABC transporter, permease G8E09_RS02085 ENOG4105E3I toluene tolerance G8E09_RS02095 ENOG4105D7N magnesium and cobalt transport protein CorA G8E09_RS02100 ENOG4108URH decarboxylase G8E09_RS02110 ENOG4105MJ2 Competence protein G8E09_RS02115 ENOG4105CB5 ATP-dependent DNA helicase recG G8E09_RS02135 ENOG4105C29 acyl-CoA thioesterase G8E09_RS02140 ENOG4105CK2 sodium dicarboxylate symporter G8E09_RS02155 ENOG4105KPV Transcriptional regulator G8E09_RS02170 ENOG4105D7A ATP-binding protein G8E09_RS02180 ENOG41089BK Glutamine amido-transferase G8E09_RS02190 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G8E09_RS02195 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G8E09_RS02290 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G8E09_RS02330 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS02365 ENOG4105VKU nucleicacid-binding protein G8E09_RS02370 ENOG4105DGW oligopeptidase A G8E09_RS02375 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G8E09_RS02425 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G8E09_RS02430 ENOG4107S2Z UPF0761 membrane protein G8E09_RS02435 ENOG4105CS1 NAD(P)H quinone oxidoreductase G8E09_RS02465 ENOG4105C9A Phoh family G8E09_RS02475 ENOG4105E4C Lytic transglycosylase catalytic G8E09_RS02505 ENOG4105D6S protein involved in catabolism of external DNA G8E09_RS02510 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G8E09_RS02555 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS02560 ENOG4108RZE Tetr family transcriptional regulator G8E09_RS02575 ENOG4107QX3 carboxylase G8E09_RS02580 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS02620 ENOG4105KB2 stringent starvation protein b G8E09_RS02625 ENOG4107MKT Stringent starvation protein a G8E09_RS02630 ENOG4108UJD 30S ribosomal protein S9 G8E09_RS02635 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G8E09_RS02640 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G8E09_RS02645 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G8E09_RS02650 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G8E09_RS02670 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G8E09_RS02680 ENOG4107RZC phospholipase d G8E09_RS02695 ENOG4108KHX Diguanylate cyclase G8E09_RS02700 ENOG4108WS1 G8E09_RS02740 ENOG4107QN2 dihydrolipoyl dehydrogenase G8E09_RS02755 ENOG4107U2T alpha beta G8E09_RS02765 ENOG4105NAU thioesterase Superfamily protein G8E09_RS02800 ENOG4105K9H YciI-like protein G8E09_RS02815 ENOG4105FFC UPF0187 protein G8E09_RS02825 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G8E09_RS02830 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G8E09_RS02835 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G8E09_RS02840 ENOG4105VIE preprotein translocase, subunit YajC G8E09_RS02860 ENOG4105BZU Histidine kinase G8E09_RS02865 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G8E09_RS02870 ENOG4105CM2 brancheD-chain amino acid aminotransferase G8E09_RS02885 ENOG4107BJW polysaccharide deacetylase G8E09_RS02895 ENOG4105CG5 Glycosyl transferase (Group 1 G8E09_RS02920 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G8E09_RS02940 ENOG4105K64 Glycosyl transferase, family 2 G8E09_RS02960 ENOG4105UGU tonB-dependent Receptor G8E09_RS02985 ENOG4105CSU acyl-Coa dehydrogenase G8E09_RS02990 ENOG4105CSU acyl-Coa dehydrogenase G8E09_RS03000 ENOG4105EB3 Histidine kinase G8E09_RS03005 ENOG4105E3W Two component transcriptional regulator (Winged helix family G8E09_RS03015 ENOG4105CNG UPF0061 protein G8E09_RS03035 ENOG4108WBT adenosyltransferase G8E09_RS03040 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G8E09_RS03085 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G8E09_RS03110 ENOG4105D3R alkyl hydroperoxide reductase G8E09_RS03125 ENOG4105CSH Transporter G8E09_RS03130 ENOG4108UT2 hemolysin iii G8E09_RS03140 ENOG41082BV acetyltransferase G8E09_RS03160 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS03165 ENOG4108R6W Transcriptional regulator, ARAC family G8E09_RS03175 ENOG4105TW1 Carbohydrate-selective porin OprB G8E09_RS03180 ENOG4105DZG Dehydrogenase G8E09_RS03185 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G8E09_RS03195 ENOG410814C multidrug resistance protein G8E09_RS03205 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS03215 ENOG4108WHA ompa motb domain protein G8E09_RS03225 ENOG4105E0Y RtcB Protein G8E09_RS03230 ENOG4108IQI permease G8E09_RS03240 ENOG4105C2W permease G8E09_RS03245 ENOG4105CI3 gtp-binding protein typa G8E09_RS03265 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G8E09_RS03275 ENOG4108VX5 3-methyladenine DNA glycosylase G8E09_RS03280 ENOG4105CHB tonB-dependent Receptor G8E09_RS03285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G8E09_RS03290 ENOG4108N2Y auxin Efflux G8E09_RS03300 ENOG4105T95 Thiol disulfide interChange protein G8E09_RS03305 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G8E09_RS03320 ENOG4105K78 MarR family Transcriptional regulator G8E09_RS03325 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G8E09_RS03330 ENOG4105KWI UPF0339 protein G8E09_RS03355 ENOG4108UNF response regulator G8E09_RS03360 ENOG4105M3Z response regulator G8E09_RS03365 ENOG4108ZGA chew protein G8E09_RS03370 ENOG4105C8Q Methyl-accepting chemotaxis G8E09_RS03375 ENOG4105CBS Chea signal transduction histidine kinase G8E09_RS03395 ENOG4107PEH Entericidin EcnA/B family G8E09_RS03405 ENOG4105WD1 Membrane G8E09_RS03410 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G8E09_RS03450 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G8E09_RS03460 ENOG4105EM2 membrane G8E09_RS03465 ENOG4105C2C drug resistance transporter, Bcr CflA G8E09_RS03485 ENOG4105BZG amino acid carrier protein G8E09_RS03490 ENOG4105D78 K07001 NTE family protein G8E09_RS03495 ENOG4105C7B Threonine dehydratase G8E09_RS03505 ENOG4105C9K Endothelin-converting enzyme 1 G8E09_RS03530 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G8E09_RS03540 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G8E09_RS03550 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G8E09_RS03555 ENOG4105VQ7 Rod shape-determining protein MreD G8E09_RS03560 ENOG4108Z03 MAF-like protein G8E09_RS03565 ENOG4105C03 ribonuclease G8E09_RS03575 ENOG4105D8T Acyltransferase G8E09_RS03585 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein G8E09_RS03595 ENOG4108X0B nad(p)h dehydrogenase (quinone) G8E09_RS03620 ENOG4105CF7 AraC family transcriptional regulator G8E09_RS03645 ENOG4105C85 amino acid G8E09_RS03650 ENOG4105C7F AcnD-accessory protein PrpF G8E09_RS03655 ENOG4105CTB Polyprenyl synthetase G8E09_RS03660 ENOG4105MSB protein, conserved in bacteria G8E09_RS03675 ENOG4105D78 K07001 NTE family protein G8E09_RS03700 ENOG4105DIJ Phosphoethanolamine transferase G8E09_RS03705 ENOG4105XJC Two component transcriptional regulator (Winged helix family G8E09_RS03710 ENOG4105DHQ Histidine kinase G8E09_RS03730 ENOG4108M0I Transcriptional regulator G8E09_RS03750 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G8E09_RS03770 ENOG41082CH UPF0145 protein G8E09_RS03775 ENOG4105K8R UPF0145 protein G8E09_RS03780 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G8E09_RS03785 ENOG4105BZS acriflavin resistance protein G8E09_RS03790 ENOG4105C1P efflux transporter, rnd family, mfp subunit G8E09_RS03795 ENOG410841Q phosphoesterase PA-phosphatase related protein G8E09_RS03820 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) G8E09_RS03835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G8E09_RS03840 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G8E09_RS03855 ENOG4105CUB amino acid G8E09_RS03870 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G8E09_RS03875 ENOG41084BA UPF0250 protein G8E09_RS03880 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G8E09_RS03915 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit G8E09_RS03920 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein G8E09_RS03930 ENOG4105E33 succinate dehydrogenase G8E09_RS03945 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G8E09_RS03950 ENOG4105C7S Dehydrogenase G8E09_RS03955 ENOG4107QN2 dihydrolipoyl dehydrogenase G8E09_RS03965 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G8E09_RS03975 ENOG4105CKW Inner membrane protein yedI G8E09_RS03980 ENOG4105CGZ zinc metallopeptidase G8E09_RS03985 ENOG4105EEQ Na H antiporter G8E09_RS04000 ENOG4105PNM synthesis protein G8E09_RS04020 ENOG41080TK Universal stress protein G8E09_RS04030 ENOG4108UQ8 endoribonuclease L-psp G8E09_RS04035 ENOG4108Q5F Tetr family transcriptional regulator G8E09_RS04045 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G8E09_RS04050 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G8E09_RS04070 ENOG4105HBR Rna-binding protein G8E09_RS04080 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G8E09_RS04085 ENOG4105EEI dihydropteroate synthase G8E09_RS04135 ENOG4105CSH Transporter G8E09_RS04140 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G8E09_RS04145 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G8E09_RS04160 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G8E09_RS04175 ENOG41080IJ Diacylglycerol kinase G8E09_RS04185 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G8E09_RS04190 ENOG4105BZS acriflavin resistance protein G8E09_RS04205 ENOG4105E4C Lytic transglycosylase catalytic G8E09_RS04230 ENOG4108RRZ Transcription elongation factor GreB G8E09_RS04240 ENOG4105D01 (LipO)protein G8E09_RS04295 ENOG4105BZW Glycerate kinase G8E09_RS04300 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit G8E09_RS04305 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G8E09_RS04320 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) G8E09_RS04330 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G8E09_RS04335 ENOG4105BZG amino acid carrier protein G8E09_RS04340 ENOG4105C85 amino acid G8E09_RS04350 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G8E09_RS04370 ENOG4105N14 lysine exporter protein LysE YggA G8E09_RS04375 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G8E09_RS04380 ENOG4105BZJ Electron transfer flavoprotein G8E09_RS04385 ENOG4105C10 Electron transfer flavoprotein G8E09_RS04390 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G8E09_RS04405 ENOG4107KET secretion protein, HlyD family G8E09_RS04435 ENOG4105D60 lipoprotein releasing system transmembrane protein G8E09_RS04440 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G8E09_RS04445 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 G8E09_RS04455 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G8E09_RS04460 ENOG4107R6F Alpha Beta Hydrolase Fold protein G8E09_RS04465 ENOG4108V3E phosphoribosylglycinamide formyltransferase G8E09_RS04475 ENOG4105C02 permease G8E09_RS04525 ENOG4105KCK Peptidoglycan-associated lipoprotein G8E09_RS04530 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) G8E09_RS04540 ENOG4105M8F Biopolymer transport protein exbD tolR G8E09_RS04545 ENOG4105E02 MotA TolQ exbB proton channel G8E09_RS04550 ENOG4107YD3 Thioesterase G8E09_RS04555 ENOG4105CH2 amidohydrolase G8E09_RS04575 ENOG4108ETH Formylglycinamide ribotide synthetase G8E09_RS04580 ENOG4105C2C drug resistance transporter, Bcr CflA G8E09_RS04585 ENOG4105EGD dinuclear metal center protein, YbgI family G8E09_RS04590 ENOG4108UKI Enoyl-CoA hydratase G8E09_RS04600 ENOG4105CBN LysR family transcriptional regulator G8E09_RS04605 ENOG4108K3A Glutathione S-transferase G8E09_RS04610 ENOG4105VSH 4-oxalocrotonate tautomerase G8E09_RS04630 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G8E09_RS04645 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G8E09_RS04650 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G8E09_RS04665 ENOG4107R11 Transcriptional regulator G8E09_RS04670 ENOG4108IJ6 ABC transporter G8E09_RS04680 ENOG4108I5D sulfate abc transporter G8E09_RS04690 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G8E09_RS04695 ENOG4105YAZ 4-amino-4-deoxychorismate lyase G8E09_RS04700 ENOG4105HHA aminodeoxychorismate lyase G8E09_RS04715 ENOG4108IYU L-aspartate oxidase G8E09_RS04720 ENOG4105C0H protease G8E09_RS04730 ENOG41068WN G8E09_RS04735 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G8E09_RS04740 ENOG4105C3F Signal peptidase i G8E09_RS04750 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G8E09_RS04755 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G8E09_RS04765 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G8E09_RS04770 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G8E09_RS04775 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase G8E09_RS04780 ENOG4105EMU Dehydrogenase G8E09_RS04820 ENOG4105BZU Histidine kinase G8E09_RS04830 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G8E09_RS04840 ENOG4105DTR rard protein G8E09_RS04875 ENOG4107QS8 (LipO)protein G8E09_RS04880 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G8E09_RS04885 ENOG4105EA8 2-Nitropropane dioxygenase G8E09_RS04900 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G8E09_RS04915 ENOG4107R8N Glycosyl transferase, family 2 G8E09_RS04930 ENOG4105CVP deoxyribo-dipyrimidine photolyase G8E09_RS04935 ENOG4108YZY peptidylprolyl cis-trans isomerase G8E09_RS04940 ENOG4105CEP NADH dehydrogenase G8E09_RS04945 ENOG4105DZ1 carboxypeptidase G8E09_RS04955 ENOG4105E9K Isocitrate dehydrogenase G8E09_RS04960 ENOG4108R99 pseudouridine synthase G8E09_RS04975 ENOG4105CBP Major Facilitator G8E09_RS04980 ENOG4105EGI Transcriptional regulator G8E09_RS04985 ENOG4108ETY sodium dicarboxylate symporter G8E09_RS04990 ENOG4105JAB phenazine biosynthesis protein, phzf family G8E09_RS05020 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G8E09_RS05035 ENOG4105D3G Pseudouridine synthase G8E09_RS05040 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) G8E09_RS05055 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G8E09_RS05070 ENOG4108JPW Aminotransferase G8E09_RS05075 ENOG4105DY8 decarboxylase G8E09_RS05085 ENOG4105F7P transcriptional regulator AsnC family G8E09_RS05090 ENOG4107RA9 decarboxylase G8E09_RS05095 ENOG4105C85 amino acid G8E09_RS05100 ENOG4105CVA phosphate G8E09_RS05105 ENOG4105C8U phosphate abc transporter G8E09_RS05115 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G8E09_RS05120 ENOG4105ERU peptidase G8E09_RS05135 ENOG4107QTF adenylosuccinate lyase G8E09_RS05160 ENOG4108Z0R Transferase G8E09_RS05165 ENOG4105DZ1 carboxypeptidase G8E09_RS05185 ENOG4108K5P (LipO)protein G8E09_RS05190 ENOG4105EJC lysr family transcriptional regulator G8E09_RS05195 ENOG4105DAN ATP-dependent protease G8E09_RS05200 ENOG4105EYM Major Facilitator superfamily G8E09_RS05210 ENOG4105DHU Bile acid G8E09_RS05230 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G8E09_RS05235 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G8E09_RS05240 ENOG4105D22 carbon starvation protein G8E09_RS05245 ENOG4105VCD cytoplasmic protein G8E09_RS05295 ENOG4105C2I pirin domain protein G8E09_RS05310 ENOG4105CEY Amp-dependent synthetase and ligase G8E09_RS05325 ENOG4108IPW abc transporter atp-binding protein G8E09_RS05345 ENOG4105C0W non-ribosomal peptide synthetase G8E09_RS05350 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G8E09_RS05355 ENOG4105WQI isochorismatase G8E09_RS05375 ENOG4108JJ7 ABC transporter G8E09_RS05390 ENOG4105E4F Isochorismate synthase G8E09_RS05405 ENOG4105NX3 Membrane G8E09_RS05420 ENOG41066YJ Beta-lactamase G8E09_RS05425 ENOG4105EUJ GTP cyclohydrolase i G8E09_RS05435 ENOG4105C7W Xanthine dehydrogenase G8E09_RS05445 ENOG4108DG9 Smr protein MutS2 G8E09_RS05460 ENOG4105DDQ anthranilate synthase G8E09_RS05475 ENOG4105DUX Transporter G8E09_RS05490 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G8E09_RS05525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G8E09_RS05530 ENOG4107QNR UPF0135 protein G8E09_RS05535 ENOG4105C0H protease G8E09_RS05545 ENOG4105C6K Malic enzyme G8E09_RS05550 ENOG4105BZU Histidine kinase G8E09_RS05555 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G8E09_RS05560 ENOG4105SYT Methylenetetrahydrofolate reductase G8E09_RS05565 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G8E09_RS05580 ENOG4107QPN acyl-Coa dehydrogenase G8E09_RS05585 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G8E09_RS05590 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) G8E09_RS05600 ENOG4107RNU major facilitator superfamily MFS_1 G8E09_RS05610 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G8E09_RS05615 ENOG4105CE9 30S ribosomal protein S2 G8E09_RS05655 ENOG4105CVE Lytic murein transglycosylase G8E09_RS05660 ENOG4105CNI cell division protein FtsW G8E09_RS05675 ENOG4105E3A (ABC) transporter G8E09_RS05680 ENOG4105DA5 (ABC) transporter G8E09_RS05685 ENOG4105DFP Integrase G8E09_RS05910 ENOG4105UPP uncharacterized protein ydcA G8E09_RS05930 ENOG4105DR5 peptidase G8E09_RS06050 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G8E09_RS06060 ENOG4105ENT Efflux transporter rnd family, mfp subunit G8E09_RS06070 ENOG4105E89 ABC transporter G8E09_RS06075 ENOG4105DSP amino acid AbC transporter G8E09_RS06080 ENOG4106YG3 ABC transporter G8E09_RS06085 ENOG4108JEH abc transporter atp-binding protein G8E09_RS06095 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G8E09_RS06100 ENOG4105CFP Peptidase U32 G8E09_RS06105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G8E09_RS06110 ENOG4105JAB phenazine biosynthesis protein, phzf family G8E09_RS06115 ENOG4105DP0 ferredoxin-NADP reductase G8E09_RS06120 ENOG4108R96 Methyltransferase, YaeB family G8E09_RS06130 ENOG4107QHF type ii secretion system protein e G8E09_RS06140 ENOG4105XJC Two component transcriptional regulator (Winged helix family G8E09_RS06145 ENOG4105DHQ Histidine kinase G8E09_RS06155 ENOG4105M6F mutator MutT protein G8E09_RS06165 ENOG4105BZ4 penicillin-binding protein G8E09_RS06170 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G8E09_RS06175 ENOG4105VUT cytoplasmic protein G8E09_RS06180 ENOG4108I0Q anthranilate phosphoribosyltransferase G8E09_RS06185 ENOG4105CK2 sodium dicarboxylate symporter G8E09_RS06190 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS06205 ENOG4105CQC Prephenate dehydratase G8E09_RS06210 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G8E09_RS06220 ENOG4105CIN aminoacyl-histidine dipeptidase G8E09_RS06225 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G8E09_RS06250 ENOG4105M08 Membrane G8E09_RS06255 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G8E09_RS06265 ENOG4105VEQ Cold shock protein G8E09_RS06270 ENOG4105C1J atp-dependent rna helicase G8E09_RS06280 ENOG41069NU Nitroreductase G8E09_RS06315 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G8E09_RS06330 ENOG4105C5I Dehydrogenase G8E09_RS06335 ENOG4105ERG peptidase m48, ste24p G8E09_RS06340 ENOG4105KTH gatB Yqey G8E09_RS06370 ENOG4105D9P serine threonine protein kinase G8E09_RS06395 ENOG4105VEQ Cold shock protein G8E09_RS06415 ENOG4105D6U Sodium Glutamate Symporter G8E09_RS06420 ENOG4105CKD glutathione-regulated potassium-efflux system protein G8E09_RS06430 ENOG4105R8C Transcriptional regulator G8E09_RS06435 ENOG4105CEB Aspartate aminotransferase G8E09_RS06455 ENOG4107NQ8 LysR family Transcriptional regulator G8E09_RS06465 ENOG4105F1S paraquat-inducible protein a G8E09_RS06470 ENOG4105DY2 Paraquat-inducible protein b G8E09_RS06480 ENOG4105VT2 5-hydroxyisourate hydrolase G8E09_RS06520 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G8E09_RS06530 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G8E09_RS06535 ENOG4105DHQ Histidine kinase G8E09_RS06540 ENOG4105ETX regulatoR G8E09_RS06580 ENOG4105D2S major facilitator superfamily G8E09_RS06605 ENOG4105CK2 sodium dicarboxylate symporter G8E09_RS06615 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G8E09_RS06620 ENOG4108UMI ABC transporter, permease G8E09_RS06625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G8E09_RS06630 ENOG4105D01 (LipO)protein G8E09_RS06635 ENOG4105C12 Phosphoribosylglycinamide synthetase G8E09_RS06645 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) G8E09_RS06695 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G8E09_RS06700 ENOG4105CDU Replicative dna helicase G8E09_RS06725 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G8E09_RS06730 ENOG4105CCU oxidase (Subunit III) G8E09_RS06735 ENOG4105BZ9 Cytochrome C oxidase, subunit I G8E09_RS06740 ENOG4105E2S oxidase) subunit II G8E09_RS06765 ENOG4107BJW polysaccharide deacetylase G8E09_RS06770 ENOG4105CND Glycosyl transferase, family 2 G8E09_RS06785 ENOG4105DEN Luciferase family G8E09_RS06800 ENOG4105CC0 LysR family Transcriptional regulator G8E09_RS06815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G8E09_RS06820 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G8E09_RS06825 ENOG4105GVF (ABC) transporter G8E09_RS06840 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS06845 ENOG4108MEJ flavin reductase domain protein G8E09_RS06850 ENOG4105D06 uba thif-type nad fad binding protein G8E09_RS06860 ENOG4105KRF dihydroneopterin aldolase G8E09_RS06870 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G8E09_RS06875 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G8E09_RS06885 ENOG4105C08 Histidine kinase G8E09_RS06890 ENOG4105EEX Two component transcriptional regulator (Winged helix family G8E09_RS06895 ENOG4105CFQ glutamine synthetase G8E09_RS06910 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) G8E09_RS06915 ENOG4105CFU surface antigen G8E09_RS06935 ENOG4107QIJ Aconitate hydratase 2 G8E09_RS06945 ENOG4105EYW Ion transport protein G8E09_RS06950 ENOG4105F27 Major Facilitator G8E09_RS06965 ENOG4105DZ2 Transcriptional regulator G8E09_RS07000 ENOG4105K8N protein family UPF0079, ATPase G8E09_RS07005 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G8E09_RS07015 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G8E09_RS07020 ENOG4108TZV Membrane G8E09_RS07025 ENOG4108RCM Nitroreductase G8E09_RS07030 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G8E09_RS07040 ENOG4105CX6 glutaminyL-tRNA synthetase G8E09_RS07045 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G8E09_RS07050 ENOG4107FQ9 ethanolamine ammonia-lyase G8E09_RS07055 ENOG4105CPD ethanolamine ammonia-lyase G8E09_RS07060 ENOG4107R55 ethanolamine transporter G8E09_RS07070 ENOG4107RR1 TRANSCRIPTIONal G8E09_RS07080 ENOG4105C0A alcohol dehydrogenase G8E09_RS07085 ENOG4107QUV Domain protein G8E09_RS07110 ENOG4105CD8 aminopeptidase N G8E09_RS07125 ENOG4108D1K outer membrane usher protein G8E09_RS07150 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) G8E09_RS07160 ENOG41089BK Glutamine amido-transferase G8E09_RS07190 ENOG4105KUS lysozyme G8E09_RS07245 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium G8E09_RS07250 ENOG4105C5H ABC transporter G8E09_RS07255 ENOG41081QV Universal stress protein G8E09_RS07275 ENOG4105DKK Benzoate G8E09_RS07280 ENOG4105EW9 transcriptional regulator AsnC family G8E09_RS07285 ENOG4108NIW Leucine export protein LeuE G8E09_RS07295 ENOG4105CC0 LysR family Transcriptional regulator G8E09_RS07305 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS07310 ENOG4105CHR reductase G8E09_RS07345 ENOG4107QMP dna polymerase iii subunits gamma and tau G8E09_RS07350 ENOG4105HSS phospholipase C G8E09_RS07360 ENOG4105C0A alcohol dehydrogenase G8E09_RS07415 ENOG4105CBC glutamate synthase G8E09_RS07430 ENOG4108D1K outer membrane usher protein G8E09_RS07765 ENOG4105D8G Major Facilitator superfamily G8E09_RS07775 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G8E09_RS07780 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G8E09_RS07805 ENOG4105DUU IucA IucC family protein G8E09_RS07815 ENOG4105DJU Siderophore biosynthesis protein G8E09_RS07820 ENOG4105CIF Ornithine Cyclodeaminase G8E09_RS07850 ENOG4107QZF nitrite reductase NADPH large subunit G8E09_RS07855 ENOG4108IFG nitrite reductase, (NAD(P)H) G8E09_RS07890 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G8E09_RS07895 ENOG4105CVM Molybdenum cofactor synthesis domain protein G8E09_RS07905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G8E09_RS07910 ENOG4105T38 integral membrane protein G8E09_RS07935 ENOG4105CMR udp-glucose 4-epimerase G8E09_RS07950 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G8E09_RS08000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G8E09_RS08005 ENOG4105CUX Signal transduction histidine kinase G8E09_RS08030 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G8E09_RS08035 ENOG4105KNE Phosphatidate cytidylyltransferase G8E09_RS08045 ENOG4105DZP Membrane-associated zinc metalloprotease G8E09_RS08050 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G8E09_RS08070 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G8E09_RS08085 ENOG4105Y3E Modulates RecA activity (By similarity) G8E09_RS08095 ENOG4105VEJ Heat shock protein G8E09_RS08100 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 G8E09_RS08115 ENOG4105F7P transcriptional regulator AsnC family G8E09_RS08125 ENOG4105C85 amino acid G8E09_RS08145 ENOG4105CHH sulfate transporter G8E09_RS08155 ENOG4105D8V Glucose sorbosone dehydrogenase G8E09_RS08165 ENOG4105BZU Histidine kinase G8E09_RS08180 ENOG4105DM4 PTS System G8E09_RS08185 ENOG4105DE4 1-phosphofructokinase G8E09_RS08190 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G8E09_RS08210 ENOG4108ZJF Glcg protein G8E09_RS08215 ENOG4105CWM branched-chain amino acid transport system II carrier protein G8E09_RS08220 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G8E09_RS08225 ENOG4105CC0 LysR family Transcriptional regulator G8E09_RS08235 ENOG4105M2J Glutaredoxin G8E09_RS08240 ENOG4105C8Y Acetylornithine aminotransferase G8E09_RS08245 ENOG4105C2X Arabinose 5-phosphate isomerase G8E09_RS08270 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G8E09_RS08295 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G8E09_RS08300 ENOG4105C4M (Ubiquinol oxidase) subunit I G8E09_RS08310 ENOG4105PV3 Inner membrane protein yqiJ G8E09_RS08325 ENOG4105E0K tonB-dependent siderophore receptor G8E09_RS08335 ENOG4105HDD phospholipase G8E09_RS08340 ENOG4105CZN Potassium uptake protein G8E09_RS08350 ENOG4105C7B Threonine dehydratase G8E09_RS08380 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G8E09_RS08385 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G8E09_RS08395 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G8E09_RS08410 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G8E09_RS08450 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G8E09_RS08455 ENOG4107VMU Membrane G8E09_RS08465 ENOG4105CNM Receptor G8E09_RS08470 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G8E09_RS08480 ENOG4107QP7 CoA-transferase subunit A G8E09_RS08485 ENOG4107QNJ CoA-transferase subunit B G8E09_RS08490 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS08495 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G8E09_RS08500 ENOG4105F2Z 3-oxoadipate enol-lactonase G8E09_RS08505 ENOG4105D2S major facilitator superfamily G8E09_RS08510 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G8E09_RS08515 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta G8E09_RS08520 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha G8E09_RS08525 ENOG4105FF2 Type I DHQase G8E09_RS08530 ENOG4106JPM 3-dehydroshikimate dehydratase G8E09_RS08535 ENOG4105TW1 Carbohydrate-selective porin OprB G8E09_RS08540 ENOG4105DZG Dehydrogenase G8E09_RS08550 ENOG4105MD1 YeeE YedE family protein G8E09_RS08565 ENOG4107HP6 Transcriptional regulator G8E09_RS08570 ENOG4108PTX LysR family Transcriptional regulator G8E09_RS08575 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS08605 ENOG4105DNH Major Facilitator G8E09_RS08615 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G8E09_RS08645 ENOG4105CHR reductase G8E09_RS08665 ENOG4105F11 amine oxidase G8E09_RS08680 ENOG4105C26 Dehydrogenase G8E09_RS08685 ENOG4105F2Z 3-oxoadipate enol-lactonase G8E09_RS08690 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS08695 ENOG4107QNJ CoA-transferase subunit B G8E09_RS08700 ENOG4107QP7 CoA-transferase subunit A G8E09_RS08710 ENOG4105NN7 muconolactone delta-isomerase G8E09_RS08715 ENOG4105DTQ mandelate racemase muconate lactonizing G8E09_RS08720 ENOG4108KB2 LysR family Transcriptional regulator G8E09_RS08730 ENOG4107EJG GntR family transcriptional regulator G8E09_RS08750 ENOG4105CZJ Aldehyde dehydrogenase G8E09_RS08760 ENOG4107RGH Aldehyde dehydrogenase G8E09_RS08775 ENOG4105CH6 catalase G8E09_RS08790 ENOG4105JQN Transcriptional regulator G8E09_RS08795 ENOG4108JUA Transcriptional regulator G8E09_RS08830 ENOG4105H3G oxidoreductase G8E09_RS08835 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G8E09_RS08855 ENOG4105CXG d-lactate dehydrogenase G8E09_RS08875 ENOG4105WH1 Two component transcriptional regulator luxr family G8E09_RS08880 ENOG4105D2S major facilitator superfamily G8E09_RS08910 ENOG41088PD hydrolase G8E09_RS08920 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G8E09_RS08925 ENOG4105EQ0 Major Facilitator superfamily G8E09_RS08995 ENOG4108R1E Serine threonine protein phosphatase 1 G8E09_RS09025 ENOG4108R0M Aminoglycoside G8E09_RS09040 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS09045 ENOG4105CHR reductase G8E09_RS09050 ENOG4108JU7 Transcriptional regulator G8E09_RS09075 ENOG4105K56 Transcriptional regulator G8E09_RS09080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G8E09_RS09120 ENOG4107Z3H Transcriptional regulator, TetR family G8E09_RS09125 ENOG4108PTX LysR family Transcriptional regulator G8E09_RS09130 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G8E09_RS09135 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G8E09_RS09140 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G8E09_RS09150 ENOG4105CSU acyl-Coa dehydrogenase G8E09_RS09160 ENOG4105CEY Amp-dependent synthetase and ligase G8E09_RS09170 ENOG4105J7D transcriptional regulator G8E09_RS09200 ENOG4106P55 Transcriptional regulator G8E09_RS09225 ENOG4108JQ1 Dehydrogenase G8E09_RS09230 ENOG4105JSC dimethylmenaquinone methyltransferase G8E09_RS09250 ENOG4105EVZ LysR family transcriptional regulator G8E09_RS09255 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G8E09_RS09260 ENOG4105C26 Dehydrogenase G8E09_RS09280 ENOG4105MSY salicylate hydroxylase G8E09_RS09330 ENOG4105EHG Permease protein G8E09_RS09335 ENOG4105E0A ABC, transporter G8E09_RS09345 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G8E09_RS09445 ENOG4105ENX hydrolase G8E09_RS09450 ENOG4105EQ2 LysR family Transcriptional regulator G8E09_RS09455 ENOG4108821 RND type efflux pump G8E09_RS09465 ENOG4105VYA Uncharacterized conserved protein (DUF2132) G8E09_RS09475 ENOG4105E2B Taurine dioxygenase G8E09_RS09480 ENOG4105IJJ transcriptional regulator, crp fnr family G8E09_RS09485 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G8E09_RS09495 ENOG4105CPC Aldo Keto reductase G8E09_RS09515 ENOG4105E2B Taurine dioxygenase G8E09_RS09525 ENOG4105SG9 biopolymer transport protein, ExbD G8E09_RS09535 ENOG4105WQ5 TonB family G8E09_RS09540 ENOG4105D7T ABC transporter G8E09_RS09545 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G8E09_RS09550 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G8E09_RS09570 ENOG4105SG9 biopolymer transport protein, ExbD G8E09_RS09580 ENOG4105WQ5 TonB family G8E09_RS09585 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G8E09_RS09590 ENOG4105GVF (ABC) transporter G8E09_RS09600 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G8E09_RS09615 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G8E09_RS09620 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G8E09_RS09625 ENOG4108JU7 Transcriptional regulator G8E09_RS09640 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G8E09_RS09650 ENOG4105BZ1 (ABC) transporter G8E09_RS09655 ENOG4105BZ1 (ABC) transporter G8E09_RS09675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G8E09_RS09685 ENOG4105DEF Extracellular solute-binding protein, family 5 G8E09_RS09710 ENOG4105X0I Fimbrial G8E09_RS09765 ENOG4107RZC phospholipase d G8E09_RS09775 ENOG4105C08 Histidine kinase G8E09_RS09780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G8E09_RS09785 ENOG4105C1P efflux transporter, rnd family, mfp subunit G8E09_RS09790 ENOG4105BZS acriflavin resistance protein G8E09_RS09805 ENOG4108IGT Dipeptidase G8E09_RS09810 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E G8E09_RS09820 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) G8E09_RS09825 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) G8E09_RS09835 ENOG4107T31 5'-nucleotidase G8E09_RS09845 ENOG4105WQI isochorismatase G8E09_RS09850 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G8E09_RS09855 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G8E09_RS09860 ENOG4105E0C molybdate abc transporter G8E09_RS09865 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G8E09_RS09870 ENOG4105F4R Transcriptional regulator mode G8E09_RS09875 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit G8E09_RS09880 ENOG4108YS2 small subunit G8E09_RS09885 ENOG4105F57 Anthranilate dioxygenase reductase G8E09_RS09910 ENOG4105CHR reductase G8E09_RS09925 ENOG4105D2S major facilitator superfamily G8E09_RS09930 ENOG4105CF7 AraC family transcriptional regulator G8E09_RS09935 ENOG4105DTD Dehydrogenase G8E09_RS09940 ENOG4105CY2 Citrate transporter G8E09_RS09960 ENOG4108M0I Transcriptional regulator G8E09_RS09975 ENOG4105CRW Short chain fatty acid transporter G8E09_RS09980 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS09990 ENOG4107YNJ LysR family Transcriptional regulator G8E09_RS10005 ENOG4108IJ0 Aspartate ammonia-lyase G8E09_RS10015 ENOG4105CSH Transporter G8E09_RS10025 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G8E09_RS10030 ENOG4105KVH Transcriptional regulator G8E09_RS10035 ENOG4105UEI Transcriptional Regulator AraC Family G8E09_RS10050 ENOG4108VCT Sulfite exporter TauE/SafE G8E09_RS10060 ENOG4107S76 domain protein G8E09_RS10070 ENOG4105FFC UPF0187 protein G8E09_RS10080 ENOG4105CHR reductase G8E09_RS10095 ENOG4105CPP Dehydrogenase, E1 component G8E09_RS10100 ENOG4107R0V Pyruvate dehydrogenase G8E09_RS10105 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G8E09_RS10120 ENOG4105BZU Histidine kinase G8E09_RS10135 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G8E09_RS10140 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G8E09_RS10185 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G8E09_RS10195 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G8E09_RS10210 ENOG4105C28 cystathionine G8E09_RS10230 ENOG4105K59 histidine triad (HIT) protein G8E09_RS10255 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G8E09_RS10260 ENOG4105CNM Receptor G8E09_RS10285 ENOG4107TSN permease G8E09_RS10290 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G8E09_RS10310 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G8E09_RS10315 ENOG4108YZT Adenosylcobinamide kinase G8E09_RS10335 ENOG4108Z66 YbaK ebsC protein G8E09_RS10350 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS10355 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS10360 ENOG4105EEF Alkane 1-monooxygenase G8E09_RS10365 ENOG4105E7U AraC family transcriptional regulator G8E09_RS10370 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G8E09_RS10375 ENOG4105K70 DNA-binding protein G8E09_RS10390 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G8E09_RS10400 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G8E09_RS10405 ENOG4108Z4V iron-sulfur cluster assembly G8E09_RS10420 ENOG4108ZIT Ferredoxin, 2FE-2S G8E09_RS10425 ENOG4105F8J Adenylate Guanylate cyclase G8E09_RS10435 ENOG4108JA2 transcriptioN-repair coupling factor G8E09_RS10455 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G8E09_RS10460 ENOG4105K4T epimerase G8E09_RS10475 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase G8E09_RS10505 ENOG4105DGW oligopeptidase A G8E09_RS10510 ENOG4107QSI ABC, transporter G8E09_RS10545 ENOG4105SG9 biopolymer transport protein, ExbD G8E09_RS10555 ENOG4107QP3 malate synthase g G8E09_RS10560 ENOG4105D6Z AFG1 family ATPase G8E09_RS10570 ENOG4107RN6 Monooxygenase G8E09_RS10575 ENOG4105DWU Membrane G8E09_RS10590 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G8E09_RS10595 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G8E09_RS10610 ENOG4108Z6B deaminase G8E09_RS10630 ENOG4108RTD type II secretion system protein K G8E09_RS10655 ENOG4105F8V Hydrolase, tatD family G8E09_RS10665 ENOG4107QRG dna polymerase iii G8E09_RS10675 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G8E09_RS10680 ENOG4105BZ1 (ABC) transporter G8E09_RS10695 ENOG4105FA0 parb-like partition protein G8E09_RS10700 ENOG4107QJE Chromosome Partitioning Protein G8E09_RS10710 ENOG4108S0S Nucleotidyl transferase G8E09_RS10715 ENOG4105EHM Aminoglycoside phosphotransferase G8E09_RS10720 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G8E09_RS10725 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G8E09_RS10730 ENOG4105D2N Aldolase G8E09_RS10750 ENOG4108UHJ MAF-like protein G8E09_RS10755 ENOG4105EZE Cupin 4 family protein G8E09_RS10765 ENOG41080HT Transcriptional regulator, arsr family G8E09_RS10775 ENOG4105XPP Protein of unknown function (DUF1275) G8E09_RS10780 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme G8E09_RS10785 ENOG4105BZ1 (ABC) transporter G8E09_RS10795 ENOG4108ZX5 transcriptional regulator G8E09_RS10805 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G8E09_RS10810 ENOG4105CK7 Sodium proline symporter G8E09_RS10815 ENOG4105EW9 transcriptional regulator AsnC family G8E09_RS10820 ENOG4105C26 Dehydrogenase G8E09_RS10825 ENOG4105YGK Pfam:UPF0157 G8E09_RS10840 ENOG4108T58 Mg2 transport protein CorA G8E09_RS10850 ENOG4108YYC ycei family G8E09_RS10860 ENOG4105CV1 Transketolase (EC 2.2.1.1) G8E09_RS10885 ENOG4108HWY Beta-lactamase G8E09_RS10905 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G8E09_RS10910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G8E09_RS10930 ENOG4105X0I Fimbrial G8E09_RS10965 ENOG4108R4R Iron-regulated virulence regulatory protein G8E09_RS10970 ENOG4108IPJ Membrane G8E09_RS10980 ENOG4105ETS cytosine purines uracil thiamine allantoin G8E09_RS10990 ENOG4105HEI LysR family (Transcriptional regulator G8E09_RS11005 ENOG41067SE Tetr family transcriptional regulator G8E09_RS11020 ENOG4105EW9 transcriptional regulator AsnC family G8E09_RS11030 ENOG4105CDA abc transporter atp-binding protein G8E09_RS11035 ENOG4105DRP amino acid AbC transporter G8E09_RS11040 ENOG4105EAD ABC transporter G8E09_RS11055 ENOG4107T8P acyl-Coa dehydrogenase G8E09_RS11070 ENOG4105D01 (LipO)protein G8E09_RS11075 ENOG4105D01 (LipO)protein G8E09_RS11080 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G8E09_RS11085 ENOG4108UMI ABC transporter, permease G8E09_RS11090 ENOG4105C3G gtp-binding protein G8E09_RS11115 ENOG4108UMN azlc family G8E09_RS11120 ENOG4105ZED uncharacterized protein ygaH G8E09_RS11150 ENOG4106AXJ AraC family transcriptional regulator G8E09_RS11155 ENOG4108V06 Glutathione peroxidase G8E09_RS11165 ENOG4105CHM Aminotransferase G8E09_RS11170 ENOG4105CK2 sodium dicarboxylate symporter G8E09_RS11180 ENOG4105C0B DNA polymerase III (alpha subunit) G8E09_RS11205 ENOG4108JU3 Alkyl hydroperoxide reductase G8E09_RS11220 ENOG4108KB2 LysR family Transcriptional regulator G8E09_RS11225 ENOG4105CAU Arsenical resistance protein, ArsH G8E09_RS11230 ENOG4105D6J arsenicaL-resistance protein G8E09_RS11240 ENOG41082YX Transcriptional regulator, arsr family G8E09_RS11255 ENOG4105CPN adenine deaminase G8E09_RS11265 ENOG4105CBN LysR family transcriptional regulator G8E09_RS11275 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G8E09_RS11290 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G8E09_RS11295 ENOG4108IY8 ABC, transporter G8E09_RS11300 ENOG4106FTQ Taurine ABC transporter, periplasmic G8E09_RS11310 ENOG4105C54 Major Facilitator superfamily G8E09_RS11330 ENOG4105C4M (Ubiquinol oxidase) subunit I G8E09_RS11335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G8E09_RS11345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G8E09_RS11350 ENOG4108K70 Transcriptional regulator G8E09_RS11385 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) G8E09_RS11390 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase G8E09_RS11400 ENOG4105ETT transcriptional Regulator, LysR family G8E09_RS11410 ENOG4105DXI Major Facilitator superfamily G8E09_RS11430 ENOG41067MG lrgb family G8E09_RS11435 ENOG4105VAW lrga family G8E09_RS11440 ENOG4105CMU LysR family (Transcriptional regulator G8E09_RS11445 ENOG4108SHQ Glutathione S-transferase G8E09_RS11450 ENOG4105CYM Glutathione S-transferase G8E09_RS11455 ENOG4105CBN LysR family transcriptional regulator G8E09_RS11460 ENOG4105CHR reductase G8E09_RS11470 ENOG4105D7W serine acetyltransferase G8E09_RS11475 ENOG4105ESN nucleotide-binding protein G8E09_RS11480 ENOG4105C9B Cysteine desulfurase G8E09_RS11485 ENOG4105CCF Lysine exporter protein (Lyse ygga) G8E09_RS11490 ENOG4105EXG Transcriptional regulator G8E09_RS11495 ENOG4105CT1 (ABC) transporter G8E09_RS11500 ENOG4107RP9 extracellular solute-binding protein, family 3 G8E09_RS11510 ENOG4108HW4 amino acid AbC transporter G8E09_RS11515 ENOG4105EAD ABC transporter G8E09_RS11530 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G8E09_RS11535 ENOG4105BZU Histidine kinase G8E09_RS11545 ENOG4105EW9 transcriptional regulator AsnC family G8E09_RS11555 ENOG4105KT5 UmuD protein G8E09_RS11575 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G8E09_RS11625 ENOG4105HEI LysR family (Transcriptional regulator G8E09_RS11635 ENOG4105D2S major facilitator superfamily G8E09_RS11650 ENOG4105CEY Amp-dependent synthetase and ligase G8E09_RS11655 ENOG4105R8C Transcriptional regulator G8E09_RS11660 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS11665 ENOG4107QX3 carboxylase G8E09_RS11670 ENOG4105E39 Enoyl-CoA hydratase G8E09_RS11685 ENOG4105CC0 LysR family Transcriptional regulator G8E09_RS11700 ENOG4105CSU acyl-Coa dehydrogenase G8E09_RS11720 ENOG4107QNJ CoA-transferase subunit B G8E09_RS11725 ENOG4107QP7 CoA-transferase subunit A G8E09_RS11730 ENOG4107RGD Major Facilitator superfamily G8E09_RS11735 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS11740 ENOG4105E39 Enoyl-CoA hydratase G8E09_RS11745 ENOG4105CHR reductase G8E09_RS11750 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G8E09_RS11755 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS11765 ENOG4105EQ0 Major Facilitator superfamily G8E09_RS11770 ENOG4105EA8 2-Nitropropane dioxygenase G8E09_RS11775 ENOG4108UKI Enoyl-CoA hydratase G8E09_RS11785 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G8E09_RS11790 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS11795 ENOG4107RGD Major Facilitator superfamily G8E09_RS11800 ENOG4108KAZ Involved in phosphonate degradation (By similarity) G8E09_RS11805 ENOG4107STF Involved in phosphonate degradation (By similarity) G8E09_RS11815 ENOG4107RCV ABC transporter, permease G8E09_RS11820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G8E09_RS11825 ENOG4105C4Y ABC transporter G8E09_RS11840 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G8E09_RS11845 ENOG4107HP6 Transcriptional regulator G8E09_RS11855 ENOG4105HEI LysR family (Transcriptional regulator G8E09_RS11885 ENOG4107YAU phenylacetic acid degradation protein G8E09_RS11895 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein G8E09_RS11900 ENOG4105DZS Phenylacetate-CoA ligase G8E09_RS11905 ENOG4105CHU acetyl-coa acetyltransferase G8E09_RS11910 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G8E09_RS11915 ENOG4108UKI Enoyl-CoA hydratase G8E09_RS11920 ENOG4105E39 Enoyl-CoA hydratase G8E09_RS11925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G8E09_RS11930 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G8E09_RS11935 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G8E09_RS11940 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G8E09_RS11945 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G8E09_RS11950 ENOG4105DXM phenylacetic acid degradation protein G8E09_RS11955 ENOG4105EJQ L-serine dehydratase G8E09_RS11970 ENOG4108Z4X TRANSCRIPTIONal G8E09_RS11980 ENOG4105WPN DNA integration recombination invertion protein G8E09_RS11985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G8E09_RS12030 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G8E09_RS12040 ENOG4105EIY sodium-type flagellar protein motY G8E09_RS12095 ENOG4105E6M Sulphatase-modifying factor protein G8E09_RS12175 ENOG4105MRR Transcriptional regulator (By similarity) G8E09_RS12195 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF G8E09_RS12200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G8E09_RS12215 ENOG4105E2A Dehydrogenase G8E09_RS12220 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G8E09_RS12250 ENOG4107R4J Chloride channel G8E09_RS12255 ENOG4108JIK carboxylase G8E09_RS12275 ENOG4105C5A transporter G8E09_RS12280 ENOG4108MP6 LysR family Transcriptional regulator G8E09_RS12290 ENOG4108WQI RNA Polymerase G8E09_RS12300 ENOG4105E18 UPF0276 protein G8E09_RS12350 ENOG4105ECR NmrA family G8E09_RS12355 ENOG4105KVH Transcriptional regulator G8E09_RS12370 ENOG4108IND Tetr family transcriptional regulator G8E09_RS12390 ENOG4105BZU Histidine kinase G8E09_RS12425 ENOG4105D2S major facilitator superfamily G8E09_RS12435 ENOG4105CPW cytochrome b561 G8E09_RS12440 ENOG4107VGR Catalase G8E09_RS12465 ENOG4105VEQ Cold shock protein G8E09_RS12505 ENOG4105D5Q Arginine ornithine antiporter G8E09_RS12510 ENOG4105CRN Aminoglycoside phosphotransferase G8E09_RS12520 ENOG4108ZX5 transcriptional regulator G8E09_RS12540 ENOG4108Z4U Ferredoxin G8E09_RS12570 ENOG4105C42 Type I secretion membrane fusion protein (HlyD G8E09_RS12580 ENOG4105DFG type I secretion outer membrane protein G8E09_RS12590 ENOG4108IUZ ABC transporter G8E09_RS12595 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G8E09_RS12610 ENOG4105C2X Arabinose 5-phosphate isomerase G8E09_RS12665 ENOG4105CUY Mechanosensitive ion channel G8E09_RS12725 ENOG4105F2W methyltransferase G8E09_RS12730 ENOG4105PAD Hydrolase G8E09_RS12735 ENOG4105EW9 transcriptional regulator AsnC family G8E09_RS12745 ENOG4105II7 pyrroline-5-carboxylate reductase G8E09_RS12755 ENOG4105VEQ Cold shock protein G8E09_RS12760 ENOG4105D1S lipid A biosynthesis G8E09_RS12765 ENOG410829K Lysine exporter protein (Lyse ygga) G8E09_RS12800 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G8E09_RS12865 ENOG4105EUV Phenol 2-monooxygenase G8E09_RS12885 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein G8E09_RS12895 ENOG4108KB2 LysR family Transcriptional regulator G8E09_RS12905 ENOG4105FUY alpha subunit G8E09_RS12910 ENOG4108UKV benzoate 1,2-dioxygenase G8E09_RS12915 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein G8E09_RS12920 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase G8E09_RS12925 ENOG4105DKK Benzoate G8E09_RS12930 ENOG4105D2S major facilitator superfamily G8E09_RS12945 ENOG4105CQ7 ATP-dependent helicase G8E09_RS12950 ENOG4105D3R alkyl hydroperoxide reductase G8E09_RS12970 ENOG4108JU3 Alkyl hydroperoxide reductase G8E09_RS12980 ENOG4108K3A Glutathione S-transferase G8E09_RS12990 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G8E09_RS13005 ENOG4108TGY Glutathione S-transferase G8E09_RS13015 ENOG4108ZG0 Ompa motb domain protein G8E09_RS13020 ENOG4105CD3 dihydroorotase G8E09_RS13050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G8E09_RS13065 ENOG4108UKZ OsmC family G8E09_RS13075 ENOG4107RYR Transcriptional regulator, Crp Fnr family G8E09_RS13080 ENOG4105CPC Aldo Keto reductase G8E09_RS13095 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G8E09_RS13105 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G8E09_RS13115 ENOG4105CFH Aspartokinase G8E09_RS13125 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G8E09_RS13135 ENOG4105CPW cytochrome b561 G8E09_RS13140 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G8E09_RS13145 ENOG4105C7N Xanthine uracil vitamin C permease G8E09_RS13175 ENOG4105F95 Monooxygenase G8E09_RS13180 ENOG4105JQZ Methyltransferase G8E09_RS13185 ENOG4105EJC lysr family transcriptional regulator G8E09_RS13200 ENOG4107GFK fumarate G8E09_RS13210 ENOG4107RN6 Monooxygenase G8E09_RS13230 ENOG4105DDY UPF0142 protein ycaO G8E09_RS13235 ENOG4105EPF Outer membrane porin G8E09_RS13240 ENOG4105D2S major facilitator superfamily G8E09_RS13245 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G8E09_RS13250 ENOG4105E6M Sulphatase-modifying factor protein G8E09_RS13265 ENOG4105E3J oxidoreductase G8E09_RS13285 ENOG4108SC4 )-transporter G8E09_RS13290 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G8E09_RS13305 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS13310 ENOG4105EPF Outer membrane porin G8E09_RS13330 ENOG4105DJP Membrane G8E09_RS13335 ENOG4108ZX5 transcriptional regulator G8E09_RS13340 ENOG4107RGH Aldehyde dehydrogenase G8E09_RS13345 ENOG4105CN7 Flagellar biosynthetic protein FliP G8E09_RS13355 ENOG4105DD5 Flagellar motor switch protein G8E09_RS13365 ENOG4105BZE flagellar hook protein, FlgE G8E09_RS13370 ENOG410822I Flagellar hook capping protein G8E09_RS13400 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G8E09_RS13405 ENOG41084DA flagellar hook-basal body complex protein fliE G8E09_RS13410 ENOG4108ZC9 flagellar basal-body rod protein flgc G8E09_RS13420 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) G8E09_RS13425 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) G8E09_RS13435 ENOG4105CGA flagellar basal-body rod protein FlgG G8E09_RS13445 ENOG4105D7B Flagellar biosynthesis protein flha G8E09_RS13450 ENOG4105D00 flagellar biosynthetic protein flhB G8E09_RS13455 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G8E09_RS13460 ENOG4105VS8 Flagellar biosynthetic protein fliq G8E09_RS13490 ENOG4105C85 amino acid G8E09_RS13510 ENOG4105C26 Dehydrogenase G8E09_RS13530 ENOG4105CUB amino acid G8E09_RS13540 ENOG4105C85 amino acid G8E09_RS13565 ENOG4105CS6 Rhs element vgr protein G8E09_RS13575 ENOG4108M3P Membrane G8E09_RS13595 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G8E09_RS13615 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) G8E09_RS13640 ENOG4108JQ5 ABC transporter G8E09_RS13645 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G8E09_RS13650 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G8E09_RS13655 ENOG4105E43 Extracellular solute-binding protein, family 5 G8E09_RS13660 ENOG4105E9H Lytic Murein transglycosylase G8E09_RS13665 ENOG4107RZZ dna polymerase iii epsilon subunit G8E09_RS13675 ENOG4105E09 nadh pyrophosphatase G8E09_RS13685 ENOG4105W4M Transport-associated protein G8E09_RS13695 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G8E09_RS13710 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G8E09_RS13720 ENOG4105W1Y Transcriptional regulator G8E09_RS13730 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G8E09_RS13735 ENOG4105D0A hydroxylase G8E09_RS13740 ENOG4107RAQ aminopeptidase G8E09_RS13780 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G8E09_RS13795 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G8E09_RS13805 ENOG4105D82 Glutamate dehydrogenase G8E09_RS13810 ENOG4108R3D Electron transport complex G8E09_RS13815 ENOG4105CSM endonuclease III G8E09_RS13840 ENOG4105CJN penicillin-binding protein G8E09_RS13845 ENOG4106H78 methyltransferase G8E09_RS13860 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G8E09_RS13870 ENOG4105CQM Urea amidohydrolase subunit alpha G8E09_RS13895 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion G8E09_RS13900 ENOG4107RET Isocitrate lyase G8E09_RS13910 ENOG4105C37 (CBS) domain G8E09_RS13915 ENOG4105D4T Citrate transporter G8E09_RS13930 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) G8E09_RS13945 ENOG4108MRJ G8E09_RS13965 ENOG4105VCQ rubredoxin G8E09_RS13970 ENOG4107QZF nitrite reductase NADPH large subunit G8E09_RS13975 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G8E09_RS13980 ENOG4105C5Q Transcriptional regulator G8E09_RS14005 ENOG4107U91 Rhomboid family G8E09_RS14010 ENOG4105CV6 ABC transporter, permease G8E09_RS14015 ENOG4108I0Y (ABC) transporter G8E09_RS14020 ENOG4108UJV acyl-CoA thioesterase i G8E09_RS14040 ENOG4105D05 Receptor G8E09_RS14055 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G8E09_RS14060 ENOG4105E6M Sulphatase-modifying factor protein G8E09_RS14080 ENOG4105CJ3 phosphate transporter G8E09_RS14085 ENOG4105C3R Methionine synthase G8E09_RS14110 ENOG4108PZW LysR family Transcriptional regulator G8E09_RS14120 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G8E09_RS14125 ENOG4105EU0 Major facilitator Superfamily G8E09_RS14130 ENOG4108R6W Transcriptional regulator, ARAC family G8E09_RS14135 ENOG4105CSV Glutaminase G8E09_RS14140 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G8E09_RS14145 ENOG4105CSH Transporter G8E09_RS14155 ENOG4105C7K acetolactate synthase G8E09_RS14170 ENOG4105CHR reductase G8E09_RS14175 ENOG4108MXF Alpha Beta Hydrolase G8E09_RS14185 ENOG4105DJB Major Facilitator Superfamily G8E09_RS14200 ENOG4105CHR reductase G8E09_RS14220 ENOG41069M3 Transcriptional regulator G8E09_RS14235 ENOG4106YT9 Enoyl-CoA hydratase G8E09_RS14245 ENOG4105CND Glycosyl transferase, family 2 G8E09_RS14250 ENOG4107BJW polysaccharide deacetylase G8E09_RS14260 ENOG4108VWS Yaeq family G8E09_RS14270 ENOG4105CKI cobalamin synthesis protein G8E09_RS14280 ENOG4108S4H thioesterase Superfamily protein G8E09_RS14290 ENOG4105C94 Transporter G8E09_RS14295 ENOG4105C94 Transporter G8E09_RS14300 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G8E09_RS14325 ENOG4107QK5 Homocysteine s-methyltransferase G8E09_RS14330 ENOG4105D5Q Arginine ornithine antiporter G8E09_RS14355 ENOG4108YNN Heme oxygenase G8E09_RS14385 ENOG4108SF5 RNA Polymerase G8E09_RS14415 ENOG4105F8V Hydrolase, tatD family G8E09_RS14445 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G8E09_RS14450 ENOG4105C0R drug resistance transporter emrb qaca subfamily G8E09_RS14455 ENOG4105CW7 secretion protein, HlyD family G8E09_RS14460 ENOG4108VUY thioesterase Superfamily protein G8E09_RS14465 ENOG4105D52 delta-aminolevulinic acid dehydratase G8E09_RS14470 ENOG4105MWK D-amino acid dehydrogenase, small subunit G8E09_RS14475 ENOG4105ECP epimerase G8E09_RS14495 ENOG4107RH8 nuclease SbcCD subunit D G8E09_RS14500 ENOG4105EYH Exonuclease G8E09_RS14505 ENOG4105DFA alanine racemase domain protein G8E09_RS14510 ENOG4105CZX twitching motility protein G8E09_RS14515 ENOG4105CZX twitching motility protein G8E09_RS14520 ENOG41090R7 Ferric uptake G8E09_RS14530 ENOG4105VDB UPF0125 protein G8E09_RS14545 ENOG4105E7A Glutamine amidotransferase G8E09_RS14560 ENOG4107QKV phosphomannomutase G8E09_RS14570 ENOG4105C4R Atp-dependent dna helicase G8E09_RS14575 ENOG4108ZG0 Ompa motb domain protein G8E09_RS14580 ENOG4106HNH Acyl-transferase G8E09_RS14595 ENOG4107QMS site-determining protein G8E09_RS14615 ENOG4105CCF Lysine exporter protein (Lyse ygga) G8E09_RS14620 ENOG4105CNU cell division protein FtsK G8E09_RS14625 ENOG4105C3M thioredoxin reductase G8E09_RS14630 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G8E09_RS14640 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G8E09_RS14655 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G8E09_RS14660 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G8E09_RS14670 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G8E09_RS14685 ENOG4108YXA Membrane G8E09_RS14695 ENOG4105C4K Nad synthetase G8E09_RS14710 ENOG4105E3J oxidoreductase G8E09_RS14715 ENOG4105C26 Dehydrogenase G8E09_RS14720 ENOG4105DVW rieske (2Fe-2S) G8E09_RS14730 ENOG4105C94 Transporter G8E09_RS14735 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G8E09_RS14740 ENOG4105EJC lysr family transcriptional regulator G8E09_RS14760 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G8E09_RS14780 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G8E09_RS14785 ENOG4105C34 Pseudouridine synthase G8E09_RS14790 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G8E09_RS14795 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G8E09_RS14810 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) G8E09_RS14840 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G8E09_RS14870 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G8E09_RS14880 ENOG4105DWF phosphomethylpyrimidine kinase G8E09_RS14885 ENOG4109066 lysm domain bon superfamily protein G8E09_RS14895 ENOG4105CHR reductase G8E09_RS14900 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G8E09_RS14910 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G8E09_RS14915 ENOG4108BPE -transporting atpase G8E09_RS14920 ENOG4107RTD sua5 ycio yrdc ywlc family protein G8E09_RS14925 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G8E09_RS14930 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G8E09_RS14935 ENOG4105FE9 pseudouridine synthase G8E09_RS14945 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G8E09_RS14950 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G8E09_RS14960 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G8E09_RS14970 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G8E09_RS14975 ENOG4106UW1 Major Facilitator superfamily G8E09_RS14995 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G8E09_RS15005 ENOG4105HF0 Membrane G8E09_RS15020 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G8E09_RS15030 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G8E09_RS15075 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G8E09_RS15080 ENOG4105D1F ATP-binding protein G8E09_RS15090 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G8E09_RS15125 ENOG4105K6H D-cysteine desulfhydrase G8E09_RS15130 ENOG4105CBX hi0933 family G8E09_RS15155 ENOG4105DP0 ferredoxin-NADP reductase G8E09_RS15160 ENOG4105DUM transcriptional regulator, lysR family G8E09_RS15180 ENOG4105C8S subunit m G8E09_RS15185 ENOG4105D65 subunit l G8E09_RS15195 ENOG4107UFS subunit j G8E09_RS15210 ENOG4108IEH NADH dehydrogenase subunit g G8E09_RS15215 ENOG4107QIZ NADH dehydrogenase G8E09_RS15220 ENOG4105GKE subunit e G8E09_RS15240 ENOG4105BZU Histidine kinase G8E09_RS15250 ENOG4105E0F Histidine kinase G8E09_RS15255 ENOG4107EXC regulatoR G8E09_RS15260 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G8E09_RS15270 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G8E09_RS15275 ENOG4105JAB phenazine biosynthesis protein, phzf family G8E09_RS15325 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) G8E09_RS15340 ENOG4105ETT transcriptional Regulator, LysR family G8E09_RS15360 ENOG4105CH2 amidohydrolase G8E09_RS15390 ENOG4106P55 Transcriptional regulator G8E09_RS15405 ENOG4106P55 Transcriptional regulator G8E09_RS15410 ENOG4107EFR Flavocytochrome c G8E09_RS15435 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G8E09_RS15440 ENOG4107RGD Major Facilitator superfamily G8E09_RS15445 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS15450 ENOG4105ETT transcriptional Regulator, LysR family G8E09_RS15460 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G8E09_RS15485 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G8E09_RS15490 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G8E09_RS15515 ENOG4105E3B Multicopper oxidase G8E09_RS15525 ENOG4108HCJ Hydrolase G8E09_RS15530 ENOG4105DJV ribulose-phosphate 3-epimerase G8E09_RS15540 ENOG4105C4W S-formylglutathione hydrolase G8E09_RS15555 ENOG41072GX Peptidase M22 Glycoprotease G8E09_RS15560 ENOG4108Z0R Transferase G8E09_RS15615 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G8E09_RS15620 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G8E09_RS15625 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G8E09_RS15695 ENOG4105K56 Transcriptional regulator G8E09_RS15700 ENOG4108ZHJ Organic hydroperoxide resistance protein G8E09_RS15705 ENOG4107QHF type ii secretion system protein e G8E09_RS15725 ENOG4105C2M dna polymerase I G8E09_RS15730 ENOG4108VIA integral membrane protein G8E09_RS15735 ENOG4105II7 pyrroline-5-carboxylate reductase G8E09_RS15740 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G8E09_RS15750 ENOG4105C9X ppx gppa phosphatase G8E09_RS15760 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G8E09_RS15780 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G8E09_RS15810 ENOG41082NX 50s ribosomal protein l35 G8E09_RS15825 ENOG4105W39 Membrane G8E09_RS15830 ENOG4105CYM Glutathione S-transferase G8E09_RS15845 ENOG4105CEY Amp-dependent synthetase and ligase G8E09_RS15850 ENOG4105N42 UPF0307 protein G8E09_RS15855 ENOG41080Z8 PHOSPHOCARRIER protein G8E09_RS15875 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G8E09_RS15880 ENOG4105DJ0 Poly(A) Polymerase G8E09_RS15885 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G8E09_RS15890 ENOG4105DXN mazG family G8E09_RS15900 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G8E09_RS15915 ENOG4105C6T cysteine synthase G8E09_RS15920 ENOG4105BZU Histidine kinase G8E09_RS15925 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G8E09_RS15935 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G8E09_RS15950 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G8E09_RS15955 ENOG4105W8H transhydrogenase (subunit alpha G8E09_RS15960 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G8E09_RS15965 ENOG4106UX7 integral membrane protein G8E09_RS15990 ENOG4107QMH DNA methylase G8E09_RS16000 ENOG4105C0D helicase G8E09_RS16025 ENOG4105CS6 Rhs element vgr protein G8E09_RS16105 ENOG4105CHB tonB-dependent Receptor G8E09_RS16110 ENOG4108HWY Beta-lactamase G8E09_RS16115 ENOG4107UIE peptidase G8E09_RS16145 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G8E09_RS16155 ENOG4107RSM transcriptional regulator G8E09_RS16165 ENOG4105CUZ uba thif-type nad fad binding protein G8E09_RS16170 ENOG4107QM5 aconitate hydratase G8E09_RS16175 ENOG4105F8V Hydrolase, tatD family G8E09_RS16190 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G8E09_RS16205 ENOG4105BZU Histidine kinase G8E09_RS16210 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G8E09_RS16215 ENOG4108ZP8 Acetolactate synthase small subunit G8E09_RS16220 ENOG4105C7K acetolactate synthase G8E09_RS16240 ENOG4105DJY efflux transporter, rnd family, mfp subunit G8E09_RS16245 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G8E09_RS16250 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G8E09_RS16255 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G8E09_RS16265 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G8E09_RS16270 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G8E09_RS16280 ENOG4105VW4 glutaredoxin 3 G8E09_RS16300 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G8E09_RS16305 ENOG4105C2D reductase G8E09_RS16315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G8E09_RS16345 ENOG4105C84 Histidine ammonia-lyase G8E09_RS16355 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) G8E09_RS16375 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G8E09_RS16395 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G8E09_RS16415 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) G8E09_RS16435 ENOG4105WVQ Fe-S assembly protein IscX G8E09_RS16450 ENOG4105CN1 protease G8E09_RS16465 ENOG4106HB6 Alpha beta hydrolase G8E09_RS16475 ENOG4105C26 Dehydrogenase G8E09_RS16480 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G8E09_RS16485 ENOG4105C6Z Gluconate G8E09_RS16490 ENOG4108UHU Aldolase G8E09_RS16495 ENOG4105C01 Dihydroxy-acid dehydratase G8E09_RS16505 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G8E09_RS16510 ENOG4108DNC Involved in acetate metabolism (By similarity) G8E09_RS16515 ENOG4107GFK fumarate G8E09_RS16535 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G8E09_RS16545 ENOG4108ESX Receptor G8E09_RS16555 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G8E09_RS16565 ENOG4105DWV Homoserine O-trans-acetylase G8E09_RS16635 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G8E09_RS16660 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G8E09_RS16675 ENOG4105BZC d-serine deaminase G8E09_RS16685 ENOG4105KME endoribonuclease L-psp G8E09_RS16690 ENOG41090KI Outer membrane porin G8E09_RS16695 ENOG4105EPF Outer membrane porin G8E09_RS16700 ENOG4105DND Transcriptional regulator G8E09_RS16710 ENOG4105CE7 Amidase, hydantoinase carbamoylase family G8E09_RS16715 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G8E09_RS16720 ENOG4105MP9 class II Aldolase G8E09_RS16725 ENOG4105CSH Transporter G8E09_RS16735 ENOG4105C26 Dehydrogenase G8E09_RS16745 ENOG4105C8Y Acetylornithine aminotransferase G8E09_RS16750 ENOG4105D82 Glutamate dehydrogenase G8E09_RS16755 ENOG4105C85 amino acid G8E09_RS16765 ENOG4105EW9 transcriptional regulator AsnC family G8E09_RS16770 ENOG4105K6H D-cysteine desulfhydrase G8E09_RS16775 ENOG4105C85 amino acid G8E09_RS16780 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions G8E09_RS16800 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G8E09_RS16845 ENOG4105CIY formyltetrahydrofolate deformylase G8E09_RS16855 ENOG4107RGH Aldehyde dehydrogenase G8E09_RS16870 ENOG4105CKD glutathione-regulated potassium-efflux system protein G8E09_RS16895 ENOG4105C4R Atp-dependent dna helicase G8E09_RS16910 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G8E09_RS16920 ENOG4105KVH Transcriptional regulator G8E09_RS16930 ENOG41069P5 Protein slyX homolog G8E09_RS16935 ENOG4105C5H ABC transporter G8E09_RS16945 ENOG4105D1S lipid A biosynthesis G8E09_RS16955 ENOG4105CK2 sodium dicarboxylate symporter G8E09_RS17010 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G8E09_RS17060 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase G8E09_RS17075 ENOG4108W5M transcriptional regulator G8E09_RS17090 ENOG4105D29 Helix-turn-helix type 11 domain protein G8E09_RS17095 ENOG4107XGZ Hydrolase G8E09_RS17100 ENOG4105EI2 Pseudouridine synthase G8E09_RS17110 ENOG4105C03 ribonuclease G8E09_RS17115 ENOG4105J5T Amp-dependent synthetase and ligase G8E09_RS17130 ENOG4105CBN LysR family transcriptional regulator G8E09_RS17140 ENOG4105CSA Coproporphyrinogen iii oxidase G8E09_RS17150 ENOG4107QI1 Mate efflux family protein G8E09_RS17160 ENOG4107T8P acyl-Coa dehydrogenase G8E09_RS17190 ENOG4105BZ8 glutamate synthase G8E09_RS17200 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G8E09_RS17205 ENOG4105C5X domain protein G8E09_RS17220 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G8E09_RS17230 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G8E09_RS17240 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G8E09_RS17245 ENOG4108JU5 Magnesium and cobalt efflux protein G8E09_RS17250 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G8E09_RS17255 ENOG4108Z7R Chaperone CsaA G8E09_RS17265 ENOG4108VAU general secretion pathway protein G G8E09_RS17270 ENOG4105D7Q type ii secretion system G8E09_RS17275 ENOG4105C25 Primosomal protein n' G8E09_RS17285 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) G8E09_RS17295 ENOG4105DVC DnaJ domain protein G8E09_RS17300 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) G8E09_RS17305 ENOG4107QUT magnesium and cobalt transport protein CorA G8E09_RS17310 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G8E09_RS17325 ENOG4107QYX exodeoxyribonuclease v alpha G8E09_RS17330 ENOG4107QKA exodeoxyribonuclease V beta G8E09_RS17335 ENOG4105DSY exodeoxyribonuclease V, gamma G8E09_RS17345 ENOG4105CSR polyphosphate kinase 2 G8E09_RS17355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G8E09_RS17365 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) G8E09_RS17375 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G8E09_RS17380 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G8E09_RS17395 ENOG4105D65 subunit l G8E09_RS17400 ENOG4108ZE9 Monovalent cation H antiporter subunit C G8E09_RS17405 ENOG4107R4Z monovalent cation h antiporter subunit d G8E09_RS17410 ENOG4105SC1 monovalent cation H antiporter subunit E G8E09_RS17415 ENOG4105W4C monovalent cation H antiporter subunit F G8E09_RS17420 ENOG4105KJM monovalent cation h antiporter subunit g G8E09_RS17425 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G8E09_RS17435 ENOG4105CHV Transcription elongation factor NusA G8E09_RS17460 ENOG4107EJC Preprotein translocase subunit SecG G8E09_RS17470 ENOG4107QHF type ii secretion system protein e G8E09_RS17485 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G8E09_RS17495 ENOG4105C2N RNA methyltransferase TrmH family group 3 G8E09_RS17510 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G8E09_RS17520 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G8E09_RS17555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G8E09_RS17560 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase G8E09_RS17605 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G8E09_RS17615 ENOG4108Z6Z Transcriptional regulator G8E09_RS17625 ENOG4107ZXU DSBA oxidoreductase G8E09_RS17640 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G8E09_RS17655 ENOG4105D3Y Na H antiporter G8E09_RS17710 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G8E09_RS17715 ENOG4105PM1 preprotein translocase subunit SecE G8E09_RS17725 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G8E09_RS17755 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G8E09_RS17760 ENOG4105TV9 FHA Domain-Containing protein G8E09_RS17765 ENOG4105GVR general secretion pathway protein D G8E09_RS17780 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS G8E09_RS17805 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G8E09_RS17810 ENOG4108NEV two component transcriptional regulator, LytTR family G8E09_RS17815 ENOG4108HRK Histidine kinase G8E09_RS17830 ENOG4108UTW Plays a role in the regulation of phosphate uptake G8E09_RS17835 ENOG4105DFG type I secretion outer membrane protein G8E09_RS17845 ENOG4108RNG Permease of the drug metabolite transporter G8E09_RS17865 ENOG41087AY ADP-Ribose pyrophosphatase G8E09_RS17870 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G8E09_RS17880 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G8E09_RS17885 ENOG4105CNI cell division protein FtsW G8E09_RS17900 ENOG4105CE1 Ferrous iron transport protein b G8E09_RS17910 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G8E09_RS17915 ENOG4105T95 Thiol disulfide interChange protein G8E09_RS17920 ENOG4105D6E homoserine dehydrogenase G8E09_RS17930 ENOG41061WM D-Alanyl-D-Alanine G8E09_RS17940 ENOG4107TUY Histidine kinase G8E09_RS17945 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G8E09_RS17950 ENOG4105CN1 protease G8E09_RS17955 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G8E09_RS17960 ENOG4108K5H permease YjgP YjgQ family protein G8E09_RS18000 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G8E09_RS18010 ENOG4105BZU Histidine kinase G8E09_RS18025 ENOG4105C0P Mg chelatase subunit ChlI G8E09_RS18030 ENOG4108YYH Nadph-dependent fmn reductase G8E09_RS18035 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G8E09_RS18040 ENOG4105FB2 class II Aldolase G8E09_RS18045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G8E09_RS18060 ENOG4105EPF Outer membrane porin G8E09_RS18065 ENOG4105F0N pyrophosphate phospho-hydrolase G8E09_RS18080 ENOG4105CEY Amp-dependent synthetase and ligase G8E09_RS18085 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G8E09_RS18090 ENOG41079KZ Major Facilitator Superfamily G8E09_RS18095 ENOG4105EN6 Membrane G8E09_RS18100 ENOG4105K5B UPF0225 protein G8E09_RS18105 ENOG4105EE5 Membrane protein terC G8E09_RS18110 ENOG4108URH decarboxylase G8E09_RS18115 ENOG4105C0R drug resistance transporter emrb qaca subfamily G8E09_RS18125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G8E09_RS18135 ENOG4105E3W Two component transcriptional regulator (Winged helix family G8E09_RS18140 ENOG4105EB3 Histidine kinase G8E09_RS18145 ENOG4105CT7 inner membrane cred family protein G8E09_RS18165 ENOG4105CCT upf0313 protein G8E09_RS18185 ENOG4105CS1 NAD(P)H quinone oxidoreductase G8E09_RS18200 ENOG4105C6T cysteine synthase G8E09_RS18230 ENOG4105Y7M Transcriptional regulator, TetR family G8E09_RS18265 ENOG4105C79 DNA protecting protein DprA G8E09_RS18280 ENOG4108IND Tetr family transcriptional regulator G8E09_RS18285 ENOG4107RTG Major Facilitator superfamily G8E09_RS18295 ENOG4108V06 Glutathione peroxidase G8E09_RS18310 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G8E09_RS18320 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G8E09_RS18360 ENOG4105FDK ABC transporter G8E09_RS18365 ENOG4105FAV ABC, transporter G8E09_RS18370 ENOG410829K Lysine exporter protein (Lyse ygga) G8E09_RS18375 ENOG4105EZR dyp-type peroxidase family protein G8E09_RS18380 ENOG4107R1I NAD-dependent malic enzyme G8E09_RS18405 ENOG4105EUB pirin domain protein G8E09_RS18425 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G8E09_RS18430 ENOG4106MP8 UPF0754 membrane protein G8E09_RS18435 ENOG4108VBZ doxx family G8E09_RS18440 ENOG4105DQR SNARE associated Golgi G8E09_RS18455 ENOG4107QJE Chromosome Partitioning Protein G8E09_RS18465 ENOG4107PSF BolA-like protein G8E09_RS18510 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS18515 ENOG4107RCI amp-dependent synthetase and ligase G8E09_RS18535 ENOG4105CSH Transporter G8E09_RS18540 ENOG4105E39 Enoyl-CoA hydratase G8E09_RS18545 ENOG4105E39 Enoyl-CoA hydratase G8E09_RS18550 ENOG4105C1G acyl-Coa dehydrogenase G8E09_RS18560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G8E09_RS18565 ENOG4105C26 Dehydrogenase G8E09_RS18575 ENOG4105C85 amino acid G8E09_RS18580 ENOG4105C85 amino acid G8E09_RS18585 ENOG4105M4H endoribonuclease L-psp G8E09_RS18600 ENOG4105EW9 transcriptional regulator AsnC family G8E09_RS18625 ENOG4105D3G Pseudouridine synthase G8E09_RS18645 ENOG4108IG5 Transcriptional regulator G8E09_RS18670 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G8E09_RS18690 ENOG4108I0Z Aconitate hydratase G8E09_RS18695 ENOG4105BZN citrate synthase G8E09_RS18700 ENOG4105CR4 methylisocitrate lyase G8E09_RS18705 ENOG4105DRR Transcriptional regulator, GntR family G8E09_RS18715 ENOG4105CGF Aromatic amino acid aminotransferase G8E09_RS18720 ENOG4105CXG d-lactate dehydrogenase G8E09_RS18730 ENOG41073TP transcriptional regulator G8E09_RS18735 ENOG4105DAA L-lactate G8E09_RS18740 ENOG4107QKV phosphomannomutase G8E09_RS18745 ENOG4105CMR udp-glucose 4-epimerase G8E09_RS18755 ENOG4105C6Y Udp-glucose 6-dehydrogenase G8E09_RS18760 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G8E09_RS18770 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family G8E09_RS18775 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G8E09_RS18790 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G8E09_RS18825 ENOG4105F0R Cytidylyltransferase G8E09_RS18840 ENOG4105D2T synthase G8E09_RS18845 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase G8E09_RS18850 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G8E09_RS18860 ENOG4107QQG Dehydrogenase G8E09_RS18865 ENOG4105DAY polysaccharide export protein G8E09_RS18875 ENOG4105D75 Capsular exopolysaccharide family G8E09_RS18880 ENOG4108V1T peptidylprolyl cis-trans isomerase G8E09_RS18885 ENOG4108V1T peptidylprolyl cis-trans isomerase G8E09_RS18890 ENOG4105CJR Integral membrane protein (MviN G8E09_RS18895 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G8E09_RS18900 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G8E09_RS18910 ENOG4105HSS phospholipase C G8E09_RS18935 ENOG41062JF Transcriptional regulator G8E09_RS18940 ENOG4108Z33 Thiol disulfide Interchange Protein G8E09_RS18950 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G8E09_RS18955 ENOG4105UBK short-chain dehydrogenase reductase G8E09_RS18970 ENOG4107QZM n-acetylglutamate synthase G8E09_RS18975 ENOG4105GVF (ABC) transporter G8E09_RS18980 ENOG4105GVF (ABC) transporter G8E09_RS18985 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G8E09_RS18990 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G8E09_RS18995 ENOG4108VM9 ABC, transporter G8E09_RS19000 ENOG4108R86 Transcriptional regulator G8E09_RS19005 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G8E09_RS19015 ENOG4105DTN riboflavin biosynthesis protein ribF G8E09_RS19020 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G8E09_RS19030 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G8E09_RS19070 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G8E09_RS19125 ENOG4105CVE Lytic murein transglycosylase G8E09_RS19130 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G8E09_RS19135 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G8E09_RS19145 ENOG4105DFU Cell wall formation (By similarity) G8E09_RS19155 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G8E09_RS19160 ENOG4105DU1 integral membrane protein, terc G8E09_RS19170 ENOG4106032 Glutathionylspermidine synthase G8E09_RS19180 ENOG4107QUY Guanine deaminase G8E09_RS19185 ENOG4108UGV hypoxanthine phosphoribosyltransferase G8E09_RS19195 ENOG4105T95 Thiol disulfide interChange protein G8E09_RS19200 ENOG4105PGM cation diffusion facilitator family transporter G8E09_RS19215 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G8E09_RS19280 ENOG4105K4U addiction module toxin, RelE StbE family G8E09_RS19325 ENOG4107QJE Chromosome Partitioning Protein G8E09_RS19570 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G8E09_RS19670 ENOG4108PCE TRANSFER protein G8E09_RS19675 ENOG4105CMA conjugation trbi family protein G8E09_RS19725 ENOG4105XUP Phage derived protein Gp49-like (DUF891)