locus-tag	class	description
G8E09_RS00010	COG0592	DNA-directed DNA polymerase activity
G8E09_RS00020	COG0187	DNA topoisomerase II activity
G8E09_RS00035	COG0488	(ABC) transporter
G8E09_RS00060	COG0596	Alpha beta hydrolase
G8E09_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G8E09_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8E09_RS00100	COG0625	glutathione transferase activity
G8E09_RS00110	COG0733	neurotransmitter:sodium symporter activity
G8E09_RS00150	COG2233	PERMEase
G8E09_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E09_RS00200	COG2814	Major facilitator Superfamily
G8E09_RS00205	COG0656	L-ascorbic acid biosynthetic process
G8E09_RS00210	COG0583	DNA-binding transcription factor activity
G8E09_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8E09_RS00230	COG1064	alcohol dehydrogenase
G8E09_RS00235	COG2818	Glycosylase
G8E09_RS00250	COG1194	a g-specific adenine glycosylase
G8E09_RS00265	COG5487	UPF0391 membrane protein
G8E09_RS00270	COG2983	Belongs to the UPF0260 family
G8E09_RS00275	COG2133	pyrroloquinoline quinone binding
G8E09_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8E09_RS00285	COG2116	formate transmembrane transporter activity
G8E09_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8E09_RS00310	COG1335	isochorismatase
G8E09_RS00315	COG0385	Bile acid
G8E09_RS00320	COG0534	Mate efflux family protein
G8E09_RS00325	COG1683	Conserved Protein
G8E09_RS00340	COG0346	lactoylglutathione lyase activity
G8E09_RS00345	COG0625	glutathione transferase activity
G8E09_RS00355	COG1113	amino acid transport
G8E09_RS00365	COG0523	cobalamin synthesis protein
G8E09_RS00375	COG2188	Transcriptional regulator
G8E09_RS00405	COG0010	Belongs to the arginase family
G8E09_RS00415	COG0546	phosphoglycolate phosphatase activity
G8E09_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8E09_RS00425	COG1280	lysine exporter protein (LysE YggA)
G8E09_RS00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8E09_RS00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8E09_RS00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G8E09_RS00555	COG0534	Mate efflux family protein
G8E09_RS00560	COG0436	Aminotransferase
G8E09_RS00565	COG2733	membrane
G8E09_RS00580	COG2918	glutathione biosynthetic process
G8E09_RS00590	COG3501	Rhs element vgr protein
G8E09_RS00625	COG3150	esterase
G8E09_RS00635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
G8E09_RS00645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E09_RS00655	COG2233	PERMEase
G8E09_RS00660	COG2351	hydroxyisourate hydrolase activity
G8E09_RS00695	COG3706	GGDEF domain
G8E09_RS00710	COG1393	Belongs to the ArsC family
G8E09_RS00715	COG0708	Exodeoxyribonuclease III
G8E09_RS00745	COG0189	ligase activity
G8E09_RS00765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G8E09_RS00775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G8E09_RS00790	COG4942	peptidase
G8E09_RS00800	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8E09_RS00810	COG2119	membrane
G8E09_RS00815	COG4774	siderophore transport
G8E09_RS00820	COG0426	domain, Protein
G8E09_RS00820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E09_RS00840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8E09_RS00860	COG1902	pentaerythritol trinitrate reductase activity
G8E09_RS00865	COG1519	Transferase
G8E09_RS00870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8E09_RS00875	COG0668	transmembrane transport
G8E09_RS00885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8E09_RS00890	COG1335	isochorismatase
G8E09_RS00895	COG1522	sequence-specific DNA binding
G8E09_RS00920	COG2205	protein histidine kinase activity
G8E09_RS00920	COG2198	Histidine kinase
G8E09_RS00920	COG0784	Response regulator, receiver
G8E09_RS00925	COG3162	membrane
G8E09_RS00930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8E09_RS00940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8E09_RS00950	COG3706	GGDEF domain
G8E09_RS00960	COG1309	transcriptional regulator
G8E09_RS00980	COG0300	oxidoreductase activity
G8E09_RS00985	COG0789	Transcriptional regulator
G8E09_RS00990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8E09_RS00990	COG0352	thiamine-phosphate diphosphorylase activity
G8E09_RS00990	COG0351	phosphomethylpyrimidine kinase
G8E09_RS01000	COG2814	Major facilitator Superfamily
G8E09_RS01035	COG1002	Type II restriction enzyme, methylase subunits
G8E09_RS01045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G8E09_RS01055	COG1061	Type III restriction enzyme res subunit
G8E09_RS01060	COG1002	Type II restriction enzyme, methylase subunits
G8E09_RS01070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G8E09_RS01090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G8E09_RS01095	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS01105	COG1335	isochorismatase
G8E09_RS01145	COG2814	Major facilitator Superfamily
G8E09_RS01150	COG0583	DNA-binding transcription factor activity
G8E09_RS01175	COG0667	Aldo Keto reductase
G8E09_RS01190	COG1309	transcriptional regulator
G8E09_RS01215	COG1733	regulation of RNA biosynthetic process
G8E09_RS01220	COG2249	NAD(P)H dehydrogenase (quinone) activity
G8E09_RS01240	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
G8E09_RS01245	COG2207	Transcriptional regulator
G8E09_RS01305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G8E09_RS01320	COG2329	Antibiotic biosynthesis monooxygenase
G8E09_RS01335	COG1132	(ABC) transporter
G8E09_RS01345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G8E09_RS01355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G8E09_RS01385	COG0427	acetyl-CoA hydrolase
G8E09_RS01395	COG2205	protein histidine kinase activity
G8E09_RS01400	COG0745	RESPONSE REGULATOR receiver
G8E09_RS01410	COG0659	secondary active sulfate transmembrane transporter activity
G8E09_RS01415	COG4221	oxidoreductase activity
G8E09_RS01425	COG2814	Major facilitator Superfamily
G8E09_RS01435	COG2873	o-acetylhomoserine
G8E09_RS01440	COG0488	(ABC) transporter
G8E09_RS01520	COG0833	amino acid
G8E09_RS01565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G8E09_RS01570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8E09_RS01585	COG2226	methyltransferase
G8E09_RS01635	COG0070	glutamate synthase
G8E09_RS01635	COG0069	glutamate synthase activity
G8E09_RS01635	COG0067	glutamate synthase
G8E09_RS01640	COG0493	'glutamate synthase
G8E09_RS01650	COG1704	LemA family
G8E09_RS01655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G8E09_RS01675	COG3307	-O-antigen
G8E09_RS01695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8E09_RS01710	COG0194	GDP metabolic process
G8E09_RS01760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G8E09_RS01770	COG0335	large ribosomal subunit rRNA binding
G8E09_RS01780	COG5380	lipid catabolic process
G8E09_RS01785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G8E09_RS01810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8E09_RS01815	COG0277	FAD linked oxidase domain protein
G8E09_RS01835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
G8E09_RS01840	COG2249	NAD(P)H dehydrogenase (quinone) activity
G8E09_RS01855	COG1289	transmembrane transporter activity
G8E09_RS01865	COG0628	permease
G8E09_RS01870	COG1192	Involved in chromosome partitioning
G8E09_RS01900	COG0833	amino acid
G8E09_RS01905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8E09_RS01910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8E09_RS01920	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS01960	COG0583	DNA-binding transcription factor activity
G8E09_RS01985	COG0752	glycyl-tRNA synthetase alpha subunit
G8E09_RS02010	COG0517	IMP dehydrogenase activity
G8E09_RS02015	COG1983	PspC domain protein
G8E09_RS02025	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS02040	COG0408	coproporphyrinogen oxidase activity
G8E09_RS02060	COG0513	Belongs to the DEAD box helicase family
G8E09_RS02070	COG1127	ABC transporter
G8E09_RS02075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G8E09_RS02085	COG2854	intermembrane phospholipid transfer
G8E09_RS02095	COG0598	Magnesium transport protein CorA
G8E09_RS02105	COG0494	nUDIX hydrolase
G8E09_RS02110	COG1040	competence protein
G8E09_RS02115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8E09_RS02135	COG1946	Acyl-CoA thioesterase
G8E09_RS02140	COG1301	dicarboxylic acid transport
G8E09_RS02155	COG1959	2 iron, 2 sulfur cluster binding
G8E09_RS02160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8E09_RS02160	COG1017	nitric oxide dioxygenase activity
G8E09_RS02170	COG0433	COG0433 Predicted ATPase
G8E09_RS02175	COG0626	cystathionine gamma-synthase activity
G8E09_RS02190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G8E09_RS02195	COG0088	Forms part of the polypeptide exit tunnel
G8E09_RS02330	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS02335	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G8E09_RS02365	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G8E09_RS02370	COG0339	signal peptide processing
G8E09_RS02375	COG0557	exoribonuclease II activity
G8E09_RS02425	COG0179	Fumarylacetoacetate (FAA) hydrolase
G8E09_RS02430	COG1295	ribonuclease BN
G8E09_RS02465	COG1702	phosphate starvation-inducible protein PhoH
G8E09_RS02475	COG0739	heme binding
G8E09_RS02475	COG1196	nuclear chromosome segregation
G8E09_RS02475	COG0741	lytic transglycosylase activity
G8E09_RS02505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G8E09_RS02510	COG1183	phosphatidylcholine synthase activity
G8E09_RS02555	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS02560	COG1309	transcriptional regulator
G8E09_RS02575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8E09_RS02580	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS02620	COG2969	positive regulation of protein catabolic process
G8E09_RS02630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G8E09_RS02635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8E09_RS02640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G8E09_RS02645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G8E09_RS02650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G8E09_RS02670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8E09_RS02680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8E09_RS02685	COG1408	metallophosphoesterase
G8E09_RS02690	COG2885	chlorophyll binding
G8E09_RS02690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G8E09_RS02695	COG2199	diguanylate cyclase activity
G8E09_RS02765	COG1607	acyl-coa hydrolase
G8E09_RS02800	COG2350	Protein conserved in bacteria
G8E09_RS02815	COG3781	membrane
G8E09_RS02825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8E09_RS02830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8E09_RS02840	COG1862	Preprotein translocase
G8E09_RS02860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8E09_RS02860	COG0784	Response regulator, receiver
G8E09_RS02860	COG2205	protein histidine kinase activity
G8E09_RS02860	COG2198	Histidine kinase
G8E09_RS02865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G8E09_RS02885	COG0726	polysaccharide deacetylase
G8E09_RS02890	COG0463	Glycosyl transferase, family 2
G8E09_RS02895	COG0438	transferase activity, transferring glycosyl groups
G8E09_RS02905	COG0438	transferase activity, transferring glycosyl groups
G8E09_RS02920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G8E09_RS02940	COG1216	Glycosyl transferase, family 2
G8E09_RS02985	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS02990	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS03000	COG2205	protein histidine kinase activity
G8E09_RS03005	COG0745	RESPONSE REGULATOR receiver
G8E09_RS03015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G8E09_RS03035	COG2096	Adenosyltransferase
G8E09_RS03040	COG4206	TonB-dependent receptor
G8E09_RS03085	COG0285	dihydrofolate synthase activity
G8E09_RS03110	COG0450	alkyl hydroperoxide reductase
G8E09_RS03125	COG0477	Major facilitator Superfamily
G8E09_RS03130	COG1272	protein, Hemolysin III
G8E09_RS03140	COG2153	protein acetylation
G8E09_RS03160	COG0183	Belongs to the thiolase family
G8E09_RS03165	COG2207	Transcriptional regulator
G8E09_RS03185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E09_RS03205	COG0183	Belongs to the thiolase family
G8E09_RS03215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G8E09_RS03215	COG2885	chlorophyll binding
G8E09_RS03225	COG1690	Belongs to the RtcB family
G8E09_RS03230	COG0833	amino acid
G8E09_RS03240	COG2233	PERMEase
G8E09_RS03275	COG2094	Belongs to the DNA glycosylase MPG family
G8E09_RS03280	COG4772	TonB-dependent receptor
G8E09_RS03285	COG1902	pentaerythritol trinitrate reductase activity
G8E09_RS03290	COG0679	Auxin Efflux Carrier
G8E09_RS03300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8E09_RS03305	COG0354	folic acid binding
G8E09_RS03320	COG3189	MarR family transcriptional regulator
G8E09_RS03325	COG2824	Alkylphosphonate utilization operon protein PhnA
G8E09_RS03330	COG3422	double-strand break repair
G8E09_RS03370	COG0840	transmembrane signaling receptor activity
G8E09_RS03395	COG5510	response to toxic substance
G8E09_RS03405	COG2832	Protein of unknown function (DUF454)
G8E09_RS03410	COG1376	ErfK ybiS ycfS ynhG family protein
G8E09_RS03450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G8E09_RS03460	COG1289	transmembrane transporter activity
G8E09_RS03465	COG2814	Major facilitator Superfamily
G8E09_RS03485	COG1115	amino acid carrier protein
G8E09_RS03490	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8E09_RS03495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G8E09_RS03500	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G8E09_RS03505	COG3590	peptidase
G8E09_RS03530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8E09_RS03540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8E09_RS03545	COG1077	Cell shape determining protein MreB Mrl
G8E09_RS03550	COG1792	Involved in formation and maintenance of cell shape
G8E09_RS03555	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G8E09_RS03560	COG0424	maF-like protein
G8E09_RS03565	COG1530	ribonuclease E activity
G8E09_RS03575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8E09_RS03595	COG2249	NAD(P)H dehydrogenase (quinone) activity
G8E09_RS03620	COG2207	Transcriptional regulator
G8E09_RS03645	COG1113	amino acid transport
G8E09_RS03650	COG2828	Protein conserved in bacteria
G8E09_RS03655	COG0142	geranyltranstransferase activity
G8E09_RS03660	COG2315	Protein conserved in bacteria
G8E09_RS03675	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8E09_RS03700	COG2194	sulfuric ester hydrolase activity
G8E09_RS03705	COG0745	RESPONSE REGULATOR receiver
G8E09_RS03710	COG0642	Histidine kinase
G8E09_RS03725	COG0004	ammonium transporteR
G8E09_RS03730	COG0583	DNA-binding transcription factor activity
G8E09_RS03750	COG0525	valine-tRNA ligase activity
G8E09_RS03760	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS03770	COG0393	Putative heavy-metal-binding
G8E09_RS03775	COG0393	Putative heavy-metal-binding
G8E09_RS03780	COG1538	Outer membrane efflux protein
G8E09_RS03790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E09_RS03795	COG0671	phosphoesterase, PA-phosphatase related
G8E09_RS03820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G8E09_RS03835	COG1648	precorrin-2 dehydrogenase activity
G8E09_RS03835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G8E09_RS03840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G8E09_RS03855	COG0531	amino acid
G8E09_RS03870	COG0321	lipoyl(octanoyl) transferase activity
G8E09_RS03875	COG2921	Belongs to the UPF0250 family
G8E09_RS03915	COG2009	succinate dehydrogenase
G8E09_RS03920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G8E09_RS03925	COG1053	succinate dehydrogenase
G8E09_RS03930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G8E09_RS03955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8E09_RS03975	COG2354	Protein conserved in bacteria
G8E09_RS03980	COG2321	neutral zinc metallopeptidase
G8E09_RS04000	COG2843	Capsule synthesis protein
G8E09_RS04020	COG0589	response to stress
G8E09_RS04030	COG0251	oxidation-reduction process
G8E09_RS04035	COG1309	transcriptional regulator
G8E09_RS04050	COG0505	Belongs to the CarA family
G8E09_RS04080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8E09_RS04085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G8E09_RS04135	COG0477	Major facilitator Superfamily
G8E09_RS04140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G8E09_RS04155	COG1597	lipid kinase activity
G8E09_RS04160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G8E09_RS04185	COG0584	glycerophosphoryl diester phosphodiesterase
G8E09_RS04205	COG0741	lytic transglycosylase activity
G8E09_RS04230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8E09_RS04280	COG0778	Nitroreductase
G8E09_RS04295	COG1929	Belongs to the glycerate kinase type-1 family
G8E09_RS04300	COG0243	molybdopterin cofactor binding
G8E09_RS04305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G8E09_RS04335	COG1115	amino acid carrier protein
G8E09_RS04340	COG1113	amino acid transport
G8E09_RS04350	COG0019	diaminopimelate decarboxylase activity
G8E09_RS04370	COG1280	lysine exporter protein (LysE YggA)
G8E09_RS04375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G8E09_RS04405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E09_RS04435	COG4591	ABC-type transport system involved in lipoprotein release permease component
G8E09_RS04440	COG1136	(ABC) transporter
G8E09_RS04445	COG2333	competence protein COMEC
G8E09_RS04445	COG0658	competence protein
G8E09_RS04455	COG0616	signal peptide processing
G8E09_RS04455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G8E09_RS04460	COG0596	Alpha beta hydrolase
G8E09_RS04465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8E09_RS04475	COG0628	permease
G8E09_RS04510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8E09_RS04530	COG0823	Involved in the tonB-independent uptake of proteins
G8E09_RS04550	COG0824	Thioesterase
G8E09_RS04555	COG1473	amidohydrolase
G8E09_RS04575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8E09_RS04575	COG0047	phosphoribosylformylglycinamidine synthase activity
G8E09_RS04580	COG2814	Major facilitator Superfamily
G8E09_RS04585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8E09_RS04590	COG1024	Enoyl-CoA hydratase
G8E09_RS04595	COG1051	belongs to the nudix hydrolase family
G8E09_RS04595	COG1056	cytidyltransferase-related domain
G8E09_RS04600	COG0583	DNA-binding transcription factor activity
G8E09_RS04605	COG0625	glutathione transferase activity
G8E09_RS04610	COG1942	4-Oxalocrotonate Tautomerase
G8E09_RS04630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G8E09_RS04645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G8E09_RS04660	COG4625	pathogenesis
G8E09_RS04665	COG0583	DNA-binding transcription factor activity
G8E09_RS04670	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8E09_RS04675	COG4208	sulfate ABC transporter
G8E09_RS04680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G8E09_RS04690	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8E09_RS04695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8E09_RS04700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8E09_RS04720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8E09_RS04730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8E09_RS04735	COG0481	GTPase activity
G8E09_RS04740	COG0681	Belongs to the peptidase S26 family
G8E09_RS04750	COG0571	ribonuclease III activity
G8E09_RS04755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G8E09_RS04765	COG1381	Involved in DNA repair and RecF pathway recombination
G8E09_RS04770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G8E09_RS04780	COG4221	oxidoreductase activity
G8E09_RS04810	COG0436	Aminotransferase
G8E09_RS04830	COG0556	nucleotide-excision repair
G8E09_RS04840	COG2962	Rard protein
G8E09_RS04885	COG2070	2-Nitropropane dioxygenase
G8E09_RS04900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G8E09_RS04915	COG1215	transferase activity, transferring glycosyl groups
G8E09_RS04930	COG0415	Belongs to the DNA photolyase family
G8E09_RS04940	COG1252	NADH dehydrogenase
G8E09_RS04945	COG1686	Belongs to the peptidase S11 family
G8E09_RS04960	COG1187	pseudouridine synthase activity
G8E09_RS04975	COG0477	Major facilitator Superfamily
G8E09_RS04980	COG0583	DNA-binding transcription factor activity
G8E09_RS04995	COG0612	Peptidase, M16
G8E09_RS05020	COG0352	thiamine-phosphate diphosphorylase activity
G8E09_RS05055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8E09_RS05070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G8E09_RS05075	COG0076	glutamate decarboxylase activity
G8E09_RS05085	COG1522	sequence-specific DNA binding
G8E09_RS05090	COG3961	Belongs to the TPP enzyme family
G8E09_RS05095	COG1113	amino acid transport
G8E09_RS05100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G8E09_RS05105	COG0573	inorganic phosphate transmembrane transporter activity
G8E09_RS05115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8E09_RS05120	COG0616	signal peptide processing
G8E09_RS05160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G8E09_RS05165	COG1686	Belongs to the peptidase S11 family
G8E09_RS05190	COG0583	DNA-binding transcription factor activity
G8E09_RS05195	COG1067	ATP-dependent peptidase activity
G8E09_RS05200	COG2211	Major facilitator Superfamily
G8E09_RS05235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G8E09_RS05240	COG1966	Carbon starvation protein
G8E09_RS05245	COG2879	small protein
G8E09_RS05290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G8E09_RS05295	COG1741	Belongs to the pirin family
G8E09_RS05310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8E09_RS05315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8E09_RS05320	COG4605	iron ion homeostasis
G8E09_RS05325	COG4604	ABC transporter, ATP-binding protein
G8E09_RS05330	COG4607	ABC-type enterochelin transport system periplasmic component
G8E09_RS05335	COG4774	siderophore transport
G8E09_RS05345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8E09_RS05350	COG1021	2,3-dihydroxybenzoate-AMP ligase
G8E09_RS05355	COG3433	isochorismatase activity
G8E09_RS05355	COG1535	isochorismatase
G8E09_RS05375	COG5265	(ABC) transporter
G8E09_RS05380	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
G8E09_RS05390	COG1169	isochorismate synthase
G8E09_RS05405	COG3739	integral membrane protein
G8E09_RS05435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G8E09_RS05445	COG2840	Smr protein MutS2
G8E09_RS05460	COG0512	Glutamine amidotransferase of anthranilate synthase
G8E09_RS05475	COG3104	oligopeptide transport
G8E09_RS05480	COG0174	glutamine synthetase
G8E09_RS05490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G8E09_RS05525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8E09_RS05530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8E09_RS05535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8E09_RS05555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8E09_RS05560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G8E09_RS05565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G8E09_RS05580	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS05585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G8E09_RS05590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8E09_RS05600	COG2223	nitrite transmembrane transporter activity
G8E09_RS05610	COG0024	Methionine aminopeptidase
G8E09_RS05615	COG0052	Belongs to the universal ribosomal protein uS2 family
G8E09_RS05630	COG2207	Transcriptional regulator
G8E09_RS05655	COG2951	lytic endotransglycosylase activity
G8E09_RS05660	COG0772	Belongs to the SEDS family
G8E09_RS05675	COG0842	Transport permease protein
G8E09_RS05680	COG1131	(ABC) transporter
G8E09_RS05685	COG0582	viral genome integration into host DNA
G8E09_RS05805	COG5410	chromosome segregation
G8E09_RS05930	COG0739	heme binding
G8E09_RS06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E09_RS06070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8E09_RS06075	COG4215	(ABC) transporter
G8E09_RS06080	COG4160	amino acid transport
G8E09_RS06085	COG4598	ABC transporter
G8E09_RS06095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G8E09_RS06105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8E09_RS06110	COG0384	phenazine biosynthesis protein PhzF
G8E09_RS06120	COG1720	tRNA m6t6A37 methyltransferase activity
G8E09_RS06140	COG0745	RESPONSE REGULATOR receiver
G8E09_RS06145	COG0642	Histidine kinase
G8E09_RS06155	COG0494	nUDIX hydrolase
G8E09_RS06165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8E09_RS06170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8E09_RS06175	COG3139	Protein of unknown function (DUF1315)
G8E09_RS06180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8E09_RS06185	COG1301	dicarboxylic acid transport
G8E09_RS06190	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS06210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G8E09_RS06220	COG2195	Cleaves the N-terminal amino acid of tripeptides
G8E09_RS06225	COG1234	tRNA 3'-trailer cleavage
G8E09_RS06250	COG2363	Small membrane protein
G8E09_RS06270	COG0513	Belongs to the DEAD box helicase family
G8E09_RS06280	COG0778	Nitroreductase
G8E09_RS06310	COG1286	toxin biosynthetic process
G8E09_RS06335	COG4783	chaperone-mediated protein folding
G8E09_RS06340	COG1610	YqeY-like protein
G8E09_RS06370	COG2815	serine threonine protein kinase
G8E09_RS06370	COG0515	serine threonine protein kinase
G8E09_RS06395	COG1278	Cold shock
G8E09_RS06410	COG3243	poly(R)-hydroxyalkanoic acid synthase
G8E09_RS06415	COG0786	glutamate:sodium symporter activity
G8E09_RS06420	COG0475	glutathione-regulated potassium exporter activity
G8E09_RS06420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G8E09_RS06430	COG1309	transcriptional regulator
G8E09_RS06440	COG2985	domain, Protein
G8E09_RS06455	COG0583	DNA-binding transcription factor activity
G8E09_RS06465	COG2995	paraquat-inducible protein a
G8E09_RS06470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G8E09_RS06470	COG3008	intermembrane lipid transfer
G8E09_RS06480	COG2351	hydroxyisourate hydrolase activity
G8E09_RS06520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G8E09_RS06530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G8E09_RS06535	COG0642	Histidine kinase
G8E09_RS06540	COG0745	RESPONSE REGULATOR receiver
G8E09_RS06560	COG1794	racemase activity, acting on amino acids and derivatives
G8E09_RS06580	COG2814	Major facilitator Superfamily
G8E09_RS06605	COG1301	dicarboxylic acid transport
G8E09_RS06615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8E09_RS06620	COG2011	ABC-type metal ion transport system permease component
G8E09_RS06625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8E09_RS06635	COG0151	Belongs to the GarS family
G8E09_RS06645	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G8E09_RS06675	COG2308	Evidence 4 Homologs of previously reported genes of
G8E09_RS06685	COG1305	Transglutaminase-like
G8E09_RS06695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G8E09_RS06700	COG0305	Participates in initiation and elongation during chromosome replication
G8E09_RS06725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G8E09_RS06730	COG1845	cytochrome c oxidase, subunit III
G8E09_RS06735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G8E09_RS06765	COG1649	PFAM Uncharacterised BCR, COG1649
G8E09_RS06765	COG0726	polysaccharide deacetylase
G8E09_RS06770	COG1215	transferase activity, transferring glycosyl groups
G8E09_RS06775	COG3658	cytochrome
G8E09_RS06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E09_RS06800	COG0583	DNA-binding transcription factor activity
G8E09_RS06815	COG2890	protein-(glutamine-N5) methyltransferase activity
G8E09_RS06820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E09_RS06825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E09_RS06840	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS06845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E09_RS06860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G8E09_RS06870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G8E09_RS06875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G8E09_RS06885	COG2205	protein histidine kinase activity
G8E09_RS06890	COG0745	RESPONSE REGULATOR receiver
G8E09_RS06895	COG0174	glutamine synthetase
G8E09_RS06910	COG0477	Major facilitator Superfamily
G8E09_RS06915	COG0729	surface antigen
G8E09_RS06945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8E09_RS06950	COG2814	Major facilitator Superfamily
G8E09_RS06965	COG0583	DNA-binding transcription factor activity
G8E09_RS06980	COG1187	pseudouridine synthase activity
G8E09_RS07000	COG0802	atpase or kinase
G8E09_RS07005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G8E09_RS07015	COG1923	regulation of RNA biosynthetic process
G8E09_RS07020	COG0697	spore germination
G8E09_RS07030	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8E09_RS07040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8E09_RS07045	COG0519	Catalyzes the synthesis of GMP from XMP
G8E09_RS07045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8E09_RS07050	COG4302	ethanolamine ammonia-lyase activity
G8E09_RS07055	COG4303	Ethanolamine ammonia lyase large subunit
G8E09_RS07060	COG0531	amino acid
G8E09_RS07080	COG1454	alcohol dehydrogenase
G8E09_RS07085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8E09_RS07110	COG0308	aminopeptidase N
G8E09_RS07150	COG1605	Chorismate mutase
G8E09_RS07190	COG3772	lysozyme
G8E09_RS07215	COG0583	DNA-binding transcription factor activity
G8E09_RS07250	COG0488	(ABC) transporter
G8E09_RS07255	COG0589	response to stress
G8E09_RS07275	COG3135	benzoate transporter
G8E09_RS07280	COG1522	sequence-specific DNA binding
G8E09_RS07290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8E09_RS07295	COG0583	DNA-binding transcription factor activity
G8E09_RS07305	COG0183	Belongs to the thiolase family
G8E09_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS07315	COG2030	dehydratase
G8E09_RS07345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G8E09_RS07355	COG0824	Thioesterase
G8E09_RS07360	COG1454	alcohol dehydrogenase
G8E09_RS07385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8E09_RS07415	COG0069	glutamate synthase activity
G8E09_RS07565	COG5410	chromosome segregation
G8E09_RS07765	COG2814	Major facilitator Superfamily
G8E09_RS07780	COG0511	ligase activity, forming carbon-carbon bonds
G8E09_RS07805	COG4264	IucA IucC family
G8E09_RS07815	COG4264	IucA IucC family
G8E09_RS07820	COG2423	ornithine cyclodeaminase activity
G8E09_RS07825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8E09_RS07835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E09_RS07835	COG1116	anion transmembrane transporter activity
G8E09_RS07850	COG2146	nitrite reductase [NAD(P)H] activity
G8E09_RS07850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E09_RS07855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E09_RS07860	COG0243	molybdopterin cofactor binding
G8E09_RS07870	COG0243	molybdopterin cofactor binding
G8E09_RS07875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G8E09_RS07890	COG0521	Mo-molybdopterin cofactor biosynthetic process
G8E09_RS07890	COG0315	cyclic pyranopterin monophosphate synthase activity
G8E09_RS07895	COG0303	'Molybdopterin
G8E09_RS07905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8E09_RS07910	COG0697	spore germination
G8E09_RS07935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8E09_RS07950	COG0596	Alpha beta hydrolase
G8E09_RS08000	COG2204	response regulator
G8E09_RS08005	COG3852	Histidine kinase
G8E09_RS08030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G8E09_RS08035	COG0575	Belongs to the CDS family
G8E09_RS08050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8E09_RS08070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8E09_RS08085	COG2137	regulation of response to DNA damage stimulus
G8E09_RS08095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G8E09_RS08100	COG1011	Hydrolase
G8E09_RS08115	COG1522	sequence-specific DNA binding
G8E09_RS08125	COG1113	amino acid transport
G8E09_RS08145	COG0659	secondary active sulfate transmembrane transporter activity
G8E09_RS08180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8E09_RS08180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8E09_RS08180	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
G8E09_RS08185	COG1105	Belongs to the carbohydrate kinase PfkB family
G8E09_RS08190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8E09_RS08190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G8E09_RS08210	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G8E09_RS08220	COG0024	Methionine aminopeptidase
G8E09_RS08225	COG0583	DNA-binding transcription factor activity
G8E09_RS08235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G8E09_RS08240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8E09_RS08245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G8E09_RS08245	COG0517	IMP dehydrogenase activity
G8E09_RS08270	COG0552	protein localization to endoplasmic reticulum
G8E09_RS08290	COG4890	Cyd operon protein YbgT
G8E09_RS08295	COG1294	oxidase, subunit
G8E09_RS08310	COG1585	Membrane protein implicated in regulation of membrane protease activity
G8E09_RS08320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8E09_RS08325	COG4774	siderophore transport
G8E09_RS08340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8E09_RS08345	COG0569	domain protein
G8E09_RS08350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G8E09_RS08380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G8E09_RS08385	COG0542	response to heat
G8E09_RS08395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8E09_RS08410	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8E09_RS08410	COG1902	pentaerythritol trinitrate reductase activity
G8E09_RS08450	COG0148	phosphopyruvate hydratase activity
G8E09_RS08455	COG2323	membrane
G8E09_RS08465	COG4773	Receptor
G8E09_RS08470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G8E09_RS08480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8E09_RS08485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8E09_RS08490	COG0183	Belongs to the thiolase family
G8E09_RS08495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G8E09_RS08500	COG0596	Alpha beta hydrolase
G8E09_RS08505	COG2271	Major facilitator Superfamily
G8E09_RS08510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8E09_RS08515	COG3485	protocatechuate 3,4-dioxygenase
G8E09_RS08520	COG3485	protocatechuate 3,4-dioxygenase
G8E09_RS08525	COG0710	3-dehydroquinate dehydratase activity
G8E09_RS08530	COG3420	alginic acid biosynthetic process
G8E09_RS08535	COG3659	wide pore channel activity
G8E09_RS08540	COG4993	Dehydrogenase
G8E09_RS08550	COG2391	methyltransferase activity
G8E09_RS08565	COG1414	Transcriptional regulator
G8E09_RS08570	COG0583	DNA-binding transcription factor activity
G8E09_RS08575	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS08605	COG2814	Major facilitator Superfamily
G8E09_RS08615	COG0154	amidase activity
G8E09_RS08645	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS08655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E09_RS08665	COG3733	amine oxidase
G8E09_RS08680	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS08685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8E09_RS08690	COG0183	Belongs to the thiolase family
G8E09_RS08695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8E09_RS08700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8E09_RS08710	COG4829	muconolactone delta-isomerase
G8E09_RS08715	COG4948	Mandelate Racemase Muconate Lactonizing
G8E09_RS08720	COG0583	DNA-binding transcription factor activity
G8E09_RS08730	COG2186	Transcriptional regulator
G8E09_RS08750	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS08775	COG0753	catalase activity
G8E09_RS08795	COG3604	Transcriptional regulator
G8E09_RS08820	COG2144	transferase activity, transferring acyl groups
G8E09_RS08830	COG2072	flavoprotein involved in K transport
G8E09_RS08835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E09_RS08855	COG0277	FAD linked oxidase domain protein
G8E09_RS08875	COG2197	response regulator
G8E09_RS08880	COG2814	Major facilitator Superfamily
G8E09_RS08910	COG2267	carboxylic ester hydrolase activity
G8E09_RS08920	COG0402	S-adenosylhomocysteine deaminase activity
G8E09_RS08925	COG2814	Major facilitator Superfamily
G8E09_RS09025	COG3231	kanamycin kinase activity
G8E09_RS09040	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS09050	COG3829	transcription factor binding
G8E09_RS09075	COG1846	Transcriptional regulator
G8E09_RS09080	COG1902	pentaerythritol trinitrate reductase activity
G8E09_RS09080	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8E09_RS09120	COG1309	transcriptional regulator
G8E09_RS09125	COG0583	DNA-binding transcription factor activity
G8E09_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS09140	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS09150	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS09160	COG0318	PFAM AMP-dependent synthetase and ligase
G8E09_RS09170	COG1309	transcriptional regulator
G8E09_RS09200	COG0583	DNA-binding transcription factor activity
G8E09_RS09225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8E09_RS09230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8E09_RS09280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E09_RS09335	COG1120	ATPase activity
G8E09_RS09345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8E09_RS09445	COG1073	alpha beta
G8E09_RS09465	COG4628	conserved protein (DUF2132)
G8E09_RS09475	COG2175	clavaminate synthase activity
G8E09_RS09480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8E09_RS09495	COG0667	Aldo Keto reductase
G8E09_RS09500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E09_RS09515	COG2175	clavaminate synthase activity
G8E09_RS09545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E09_RS09550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E09_RS09555	COG4771	TonB-dependent receptor
G8E09_RS09585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E09_RS09590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E09_RS09595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E09_RS09600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E09_RS09615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8E09_RS09620	COG0805	protein transport
G8E09_RS09630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E09_RS09650	COG1132	(ABC) transporter
G8E09_RS09655	COG1132	(ABC) transporter
G8E09_RS09675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8E09_RS09680	COG0601	transmembrane transport
G8E09_RS09685	COG0747	negative chemotaxis
G8E09_RS09710	COG3539	Fimbrial protein
G8E09_RS09735	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G8E09_RS09765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8E09_RS09775	COG2205	protein histidine kinase activity
G8E09_RS09780	COG0745	RESPONSE REGULATOR receiver
G8E09_RS09785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E09_RS09790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8E09_RS09845	COG3433	isochorismatase activity
G8E09_RS09845	COG1535	isochorismatase
G8E09_RS09850	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS09855	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G8E09_RS09860	COG4149	molybdate abc transporter
G8E09_RS09865	COG0725	ABC transporter, periplasmic molybdate-binding protein
G8E09_RS09875	COG4638	Rieske (2fe-2S)
G8E09_RS09880	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G8E09_RS09885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8E09_RS09885	COG0543	2 iron, 2 sulfur cluster binding
G8E09_RS09900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E09_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS09930	COG2207	Transcriptional regulator
G8E09_RS09935	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS09940	COG2610	gluconate transmembrane transporter activity
G8E09_RS09960	COG0583	DNA-binding transcription factor activity
G8E09_RS09975	COG2031	fatty acid transporter
G8E09_RS09980	COG0183	Belongs to the thiolase family
G8E09_RS09985	COG0583	DNA-binding transcription factor activity
G8E09_RS09990	COG0583	DNA-binding transcription factor activity
G8E09_RS10005	COG1027	Aspartate ammonia-lyase
G8E09_RS10015	COG0477	Major facilitator Superfamily
G8E09_RS10025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G8E09_RS10030	COG1733	regulation of RNA biosynthetic process
G8E09_RS10035	COG2207	Transcriptional regulator
G8E09_RS10035	COG3708	Transcriptional regulator
G8E09_RS10050	COG0730	response to heat
G8E09_RS10060	COG3453	Protein conserved in bacteria
G8E09_RS10060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8E09_RS10070	COG3781	membrane
G8E09_RS10075	COG1063	alcohol dehydrogenase
G8E09_RS10085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8E09_RS10090	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8E09_RS10095	COG0022	dehydrogenase e1 component
G8E09_RS10100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G8E09_RS10105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G8E09_RS10120	COG3706	GGDEF domain
G8E09_RS10140	COG0133	tryptophan synthase activity
G8E09_RS10150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8E09_RS10180	COG0583	DNA-binding transcription factor activity
G8E09_RS10185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G8E09_RS10195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G8E09_RS10255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8E09_RS10260	COG4773	Receptor
G8E09_RS10285	COG0730	response to heat
G8E09_RS10290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8E09_RS10310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G8E09_RS10335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G8E09_RS10350	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS10355	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS10360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8E09_RS10365	COG2207	Transcriptional regulator
G8E09_RS10370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8E09_RS10375	COG0776	regulation of translation
G8E09_RS10400	COG0822	iron-sulfur transferase activity
G8E09_RS10405	COG0316	Belongs to the HesB IscA family
G8E09_RS10435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8E09_RS10455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8E09_RS10460	COG0702	epimerase
G8E09_RS10500	COG0601	transmembrane transport
G8E09_RS10505	COG0339	signal peptide processing
G8E09_RS10510	COG4166	transmembrane transport
G8E09_RS10555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G8E09_RS10560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G8E09_RS10575	COG2431	L-lysine efflux transmembrane transporter activity
G8E09_RS10590	COG0776	regulation of translation
G8E09_RS10655	COG0084	hydrolase, TatD family'
G8E09_RS10675	COG1663	tetraacyldisaccharide 4'-kinase activity
G8E09_RS10680	COG1132	(ABC) transporter
G8E09_RS10690	COG0811	peptide transport
G8E09_RS10695	COG1475	DNA binding
G8E09_RS10700	COG1192	Involved in chromosome partitioning
G8E09_RS10710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G8E09_RS10715	COG3178	'Phosphotransferase
G8E09_RS10725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8E09_RS10750	COG0424	maF-like protein
G8E09_RS10755	COG2850	peptidyl-arginine hydroxylation
G8E09_RS10765	COG0640	Transcriptional regulator
G8E09_RS10775	COG3619	membrane
G8E09_RS10780	COG3122	Protein conserved in bacteria
G8E09_RS10785	COG1132	(ABC) transporter
G8E09_RS10805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G8E09_RS10810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8E09_RS10820	COG0506	proline dehydrogenase activity
G8E09_RS10820	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G8E09_RS10820	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G8E09_RS10825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G8E09_RS10840	COG3698	Phosphodiester glycosidase
G8E09_RS10850	COG2353	YceI-like domain
G8E09_RS10860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G8E09_RS10905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G8E09_RS10905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G8E09_RS10930	COG3539	Fimbrial protein
G8E09_RS10965	COG0583	DNA-binding transcription factor activity
G8E09_RS10970	COG0697	spore germination
G8E09_RS10980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G8E09_RS10990	COG0583	DNA-binding transcription factor activity
G8E09_RS11005	COG1309	transcriptional regulator
G8E09_RS11020	COG1522	sequence-specific DNA binding
G8E09_RS11030	COG1126	abc transporter atp-binding protein
G8E09_RS11035	COG0765	amino acid transport
G8E09_RS11040	COG0765	amino acid transport
G8E09_RS11070	COG1464	Belongs to the NlpA lipoprotein family
G8E09_RS11080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8E09_RS11085	COG2011	ABC-type metal ion transport system permease component
G8E09_RS11090	COG0012	GTP binding
G8E09_RS11115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G8E09_RS11150	COG2207	Transcriptional regulator
G8E09_RS11150	COG1917	Cupin 2, conserved barrel domain protein
G8E09_RS11155	COG0386	Belongs to the glutathione peroxidase family
G8E09_RS11165	COG0436	Aminotransferase
G8E09_RS11170	COG1301	dicarboxylic acid transport
G8E09_RS11205	COG3634	alkyl hydroperoxide reductase activity
G8E09_RS11220	COG0583	DNA-binding transcription factor activity
G8E09_RS11225	COG0431	NADPH-dependent FMN reductase
G8E09_RS11230	COG0798	PFAM Bile acid sodium symporter
G8E09_RS11240	COG0640	Transcriptional regulator
G8E09_RS11255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G8E09_RS11265	COG0583	DNA-binding transcription factor activity
G8E09_RS11275	COG1953	Uracil, thiamine, allantoin
G8E09_RS11285	COG2175	clavaminate synthase activity
G8E09_RS11290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E09_RS11295	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G8E09_RS11300	COG4521	taurine ABC transporter
G8E09_RS11310	COG0477	Major facilitator Superfamily
G8E09_RS11330	COG1271	oxidase subunit
G8E09_RS11335	COG1294	oxidase, subunit
G8E09_RS11345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8E09_RS11365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G8E09_RS11385	COG3052	prosthetic group binding
G8E09_RS11390	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
G8E09_RS11400	COG0583	DNA-binding transcription factor activity
G8E09_RS11410	COG2814	Major facilitator Superfamily
G8E09_RS11430	COG1346	cytolysis
G8E09_RS11440	COG0583	DNA-binding transcription factor activity
G8E09_RS11445	COG0625	glutathione transferase activity
G8E09_RS11450	COG0625	glutathione transferase activity
G8E09_RS11455	COG0583	DNA-binding transcription factor activity
G8E09_RS11470	COG1045	serine acetyltransferase
G8E09_RS11475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8E09_RS11480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G8E09_RS11485	COG1280	lysine exporter protein (LysE YggA)
G8E09_RS11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8E09_RS11500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8E09_RS11510	COG0765	amino acid transport
G8E09_RS11515	COG0765	amino acid transport
G8E09_RS11535	COG0784	Response regulator, receiver
G8E09_RS11535	COG2205	protein histidine kinase activity
G8E09_RS11555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G8E09_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS11625	COG0583	DNA-binding transcription factor activity
G8E09_RS11635	COG2814	Major facilitator Superfamily
G8E09_RS11650	COG0318	PFAM AMP-dependent synthetase and ligase
G8E09_RS11655	COG1309	transcriptional regulator
G8E09_RS11660	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS11665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8E09_RS11670	COG1024	Enoyl-CoA hydratase
G8E09_RS11675	COG4770	biotin carboxylase activity
G8E09_RS11685	COG0583	DNA-binding transcription factor activity
G8E09_RS11700	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS11710	COG2814	Major facilitator Superfamily
G8E09_RS11720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8E09_RS11725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8E09_RS11730	COG2814	Major facilitator Superfamily
G8E09_RS11735	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS11740	COG1024	Enoyl-CoA hydratase
G8E09_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8E09_RS11755	COG0183	Belongs to the thiolase family
G8E09_RS11765	COG2814	Major facilitator Superfamily
G8E09_RS11775	COG1024	Enoyl-CoA hydratase
G8E09_RS11785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8E09_RS11790	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS11795	COG2814	Major facilitator Superfamily
G8E09_RS11800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8E09_RS11805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G8E09_RS11820	COG3842	ATPase activity
G8E09_RS11825	COG1840	ABC-type Fe3 transport system, periplasmic component
G8E09_RS11840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E09_RS11845	COG1414	Transcriptional regulator
G8E09_RS11855	COG0583	DNA-binding transcription factor activity
G8E09_RS11885	COG2050	protein possibly involved in aromatic compounds catabolism
G8E09_RS11895	COG3327	negative regulation of DNA-templated transcription, initiation
G8E09_RS11900	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
G8E09_RS11905	COG0183	Belongs to the thiolase family
G8E09_RS11910	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8E09_RS11915	COG1024	Enoyl-CoA hydratase
G8E09_RS11920	COG1024	Enoyl-CoA hydratase
G8E09_RS11925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8E09_RS11930	COG2151	metal-sulfur cluster biosynthetic enzyme
G8E09_RS11935	COG3396	Phenylacetate-CoA oxygenase
G8E09_RS11940	COG3460	Phenylacetate-CoA oxygenase
G8E09_RS11945	COG3396	Phenylacetate-CoA oxygenase
G8E09_RS11950	COG2030	dehydratase
G8E09_RS11950	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS11955	COG1760	l-serine dehydratase
G8E09_RS11970	COG0789	Transcriptional regulator
G8E09_RS11980	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G8E09_RS11985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8E09_RS12040	COG2885	chlorophyll binding
G8E09_RS12095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8E09_RS12160	COG1116	anion transmembrane transporter activity
G8E09_RS12175	COG0864	Transcriptional regulator
G8E09_RS12190	COG1733	regulation of RNA biosynthetic process
G8E09_RS12195	COG2249	NAD(P)H dehydrogenase (quinone) activity
G8E09_RS12200	COG0439	Biotin carboxylase
G8E09_RS12215	COG1063	alcohol dehydrogenase
G8E09_RS12220	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8E09_RS12250	COG0038	chloride channel
G8E09_RS12255	COG4770	biotin carboxylase activity
G8E09_RS12275	COG1914	H( )-stimulated, divalent metal cation uptake system
G8E09_RS12290	COG1595	DNA-templated transcription, initiation
G8E09_RS12300	COG3220	belongs to the UPF0276 family
G8E09_RS12350	COG0702	epimerase
G8E09_RS12355	COG1733	regulation of RNA biosynthetic process
G8E09_RS12370	COG1309	transcriptional regulator
G8E09_RS12435	COG3038	cytochrome b561
G8E09_RS12440	COG0753	catalase activity
G8E09_RS12465	COG1278	Cold shock
G8E09_RS12500	COG1522	sequence-specific DNA binding
G8E09_RS12505	COG0531	amino acid
G8E09_RS12510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G8E09_RS12525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G8E09_RS12540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G8E09_RS12550	COG4122	O-methyltransferase activity
G8E09_RS12580	COG1538	Outer membrane efflux protein
G8E09_RS12590	COG1137	ATPase activity
G8E09_RS12595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G8E09_RS12605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G8E09_RS12655	COG2814	Major facilitator Superfamily
G8E09_RS12665	COG0668	transmembrane transport
G8E09_RS12725	COG2226	methyltransferase
G8E09_RS12730	COG1011	Hydrolase
G8E09_RS12755	COG1278	Cold shock
G8E09_RS12760	COG1560	Kdo2-lipid A biosynthetic process
G8E09_RS12765	COG1280	lysine exporter protein (LysE YggA)
G8E09_RS12800	COG1570	exodeoxyribonuclease VII activity
G8E09_RS12885	COG2871	sodium ion transport
G8E09_RS12895	COG0583	DNA-binding transcription factor activity
G8E09_RS12905	COG4638	Rieske (2fe-2S)
G8E09_RS12910	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G8E09_RS12915	COG0543	2 iron, 2 sulfur cluster binding
G8E09_RS12915	COG0633	Ferredoxin
G8E09_RS12920	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS12925	COG3135	benzoate transporter
G8E09_RS12930	COG2814	Major facilitator Superfamily
G8E09_RS12945	COG1643	Atp-dependent helicase
G8E09_RS12970	COG3634	alkyl hydroperoxide reductase activity
G8E09_RS12990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G8E09_RS13005	COG0625	glutathione transferase activity
G8E09_RS13015	COG2885	chlorophyll binding
G8E09_RS13050	COG0542	response to heat
G8E09_RS13065	COG1765	OsmC-like protein
G8E09_RS13080	COG0667	Aldo Keto reductase
G8E09_RS13095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G8E09_RS13105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G8E09_RS13115	COG0527	aspartate kinase activity
G8E09_RS13125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G8E09_RS13135	COG3038	cytochrome b561
G8E09_RS13140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G8E09_RS13145	COG2252	PERMEase
G8E09_RS13155	COG1741	Belongs to the pirin family
G8E09_RS13160	COG1309	transcriptional regulator
G8E09_RS13175	COG2072	flavoprotein involved in K transport
G8E09_RS13180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G8E09_RS13185	COG0583	DNA-binding transcription factor activity
G8E09_RS13200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G8E09_RS13230	COG1944	ATP diphosphatase activity
G8E09_RS13250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8E09_RS13265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8E09_RS13285	COG2814	Major facilitator Superfamily
G8E09_RS13290	COG1024	Enoyl-CoA hydratase
G8E09_RS13295	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS13305	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS13330	COG0697	spore germination
G8E09_RS13355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G8E09_RS13370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G8E09_RS13385	COG1157	protein secretion by the type III secretion system
G8E09_RS13400	COG1766	The M ring may be actively involved in energy transduction
G8E09_RS13405	COG1677	Flagellar hook-basal body complex protein FliE
G8E09_RS13410	COG1558	bacterial-type flagellum-dependent cell motility
G8E09_RS13420	COG1706	bacterial-type flagellum-dependent cell motility
G8E09_RS13425	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G8E09_RS13435	COG4786	Flagellar basal body rod
G8E09_RS13445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G8E09_RS13450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G8E09_RS13455	COG1684	flagellar biosynthetic protein fliR
G8E09_RS13460	COG1987	bacterial-type flagellum assembly
G8E09_RS13490	COG1113	amino acid transport
G8E09_RS13510	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS13530	COG0531	amino acid
G8E09_RS13540	COG1113	amino acid transport
G8E09_RS13565	COG3501	Rhs element vgr protein
G8E09_RS13575	COG4269	membrane
G8E09_RS13595	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8E09_RS13595	COG1902	pentaerythritol trinitrate reductase activity
G8E09_RS13605	COG4251	negative regulation of phosphorylation
G8E09_RS13605	COG5001	Diguanylate cyclase
G8E09_RS13605	COG2203	Gaf domain
G8E09_RS13605	COG3706	GGDEF domain
G8E09_RS13615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8E09_RS13640	COG4172	Belongs to the ABC transporter superfamily
G8E09_RS13645	COG4239	(ABC) transporter, permease
G8E09_RS13650	COG4174	ABC transporter (Permease)
G8E09_RS13655	COG4166	transmembrane transport
G8E09_RS13660	COG1388	LysM domain
G8E09_RS13660	COG0741	lytic transglycosylase activity
G8E09_RS13705	COG0583	DNA-binding transcription factor activity
G8E09_RS13710	COG1279	arginine transmembrane transporter activity
G8E09_RS13720	COG0789	Transcriptional regulator
G8E09_RS13730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E09_RS13735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E09_RS13740	COG0006	proline dipeptidase activity
G8E09_RS13780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G8E09_RS13795	COG3384	dioxygenase
G8E09_RS13805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8E09_RS13810	COG2878	Part of a membrane complex involved in electron transport
G8E09_RS13815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G8E09_RS13840	COG0768	penicillin binding
G8E09_RS13845	COG0742	ribosomal rna small subunit methyltransferase
G8E09_RS13860	COG0830	nickel cation binding
G8E09_RS13870	COG0804	urea catabolic process
G8E09_RS13895	COG3015	lipoprotein NlpE involved in copper resistance
G8E09_RS13910	COG1253	flavin adenine dinucleotide binding
G8E09_RS13915	COG2851	Citrate transporter
G8E09_RS13965	COG1773	rubredoxin
G8E09_RS13970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8E09_RS13975	COG2267	carboxylic ester hydrolase activity
G8E09_RS13980	COG0583	DNA-binding transcription factor activity
G8E09_RS14010	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G8E09_RS14015	COG4181	ATPase activity
G8E09_RS14040	COG4771	TonB-dependent receptor
G8E09_RS14060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8E09_RS14080	COG0306	phosphate transporter
G8E09_RS14090	COG3958	Transketolase
G8E09_RS14095	COG3959	Transketolase, thiamine diphosphate binding domain
G8E09_RS14105	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS14110	COG0583	DNA-binding transcription factor activity
G8E09_RS14125	COG2223	nitrite transmembrane transporter activity
G8E09_RS14130	COG2207	Transcriptional regulator
G8E09_RS14135	COG2066	Belongs to the glutaminase family
G8E09_RS14140	COG0242	peptide deformylase activity
G8E09_RS14145	COG0477	Major facilitator Superfamily
G8E09_RS14155	COG0028	Belongs to the TPP enzyme family
G8E09_RS14170	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS14175	COG2267	carboxylic ester hydrolase activity
G8E09_RS14185	COG2271	Major facilitator Superfamily
G8E09_RS14200	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS14220	COG1414	Transcriptional regulator
G8E09_RS14235	COG1024	Enoyl-CoA hydratase
G8E09_RS14245	COG1215	transferase activity, transferring glycosyl groups
G8E09_RS14250	COG0726	polysaccharide deacetylase
G8E09_RS14250	COG1649	PFAM Uncharacterised BCR, COG1649
G8E09_RS14260	COG4681	YaeQ
G8E09_RS14270	COG0523	cobalamin synthesis protein
G8E09_RS14280	COG1607	acyl-coa hydrolase
G8E09_RS14290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8E09_RS14295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8E09_RS14300	COG1309	transcriptional regulator
G8E09_RS14325	COG2040	homocysteine
G8E09_RS14330	COG0531	amino acid
G8E09_RS14385	COG1595	DNA-templated transcription, initiation
G8E09_RS14445	COG0405	Gamma-glutamyltransferase
G8E09_RS14450	COG2814	Major facilitator Superfamily
G8E09_RS14460	COG2050	protein possibly involved in aromatic compounds catabolism
G8E09_RS14475	COG1090	epimerase
G8E09_RS14495	COG0420	3'-5' exonuclease activity
G8E09_RS14520	COG0735	belongs to the Fur family
G8E09_RS14525	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8E09_RS14530	COG2914	Belongs to the UPF0125 (RnfH) family
G8E09_RS14545	COG0121	glutamine amidotransferase
G8E09_RS14560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8E09_RS14570	COG0210	DNA helicase
G8E09_RS14575	COG2885	chlorophyll binding
G8E09_RS14580	COG0204	Acyl-transferase
G8E09_RS14595	COG2894	cell division
G8E09_RS14615	COG1280	lysine exporter protein (LysE YggA)
G8E09_RS14620	COG1674	ftsk spoiiie
G8E09_RS14625	COG0492	ferredoxin-NADP+ reductase activity
G8E09_RS14630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G8E09_RS14640	COG0456	acetyltransferase
G8E09_RS14655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G8E09_RS14660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G8E09_RS14670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G8E09_RS14695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G8E09_RS14695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8E09_RS14715	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS14720	COG4638	Rieske (2fe-2S)
G8E09_RS14735	COG0473	3-isopropylmalate dehydrogenase activity
G8E09_RS14740	COG0583	DNA-binding transcription factor activity
G8E09_RS14760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G8E09_RS14795	COG0358	DNA primase activity
G8E09_RS14810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G8E09_RS14840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8E09_RS14870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8E09_RS14880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8E09_RS14880	COG0352	thiamine-phosphate diphosphorylase activity
G8E09_RS14880	COG0351	phosphomethylpyrimidine kinase
G8E09_RS14885	COG1652	LysM domain
G8E09_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS14910	COG1399	metal-binding, possibly nucleic acid-binding protein
G8E09_RS14915	COG3101	peptidyl-lysine hydroxylation
G8E09_RS14920	COG0009	L-threonylcarbamoyladenylate synthase
G8E09_RS14925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G8E09_RS14930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G8E09_RS14945	COG4106	trans-aconitate 2-methyltransferase activity
G8E09_RS14960	COG0596	Alpha beta hydrolase
G8E09_RS14960	COG2226	methyltransferase
G8E09_RS14960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8E09_RS14970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G8E09_RS14975	COG2223	nitrite transmembrane transporter activity
G8E09_RS14995	COG1196	nuclear chromosome segregation
G8E09_RS15005	COG0730	response to heat
G8E09_RS15020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8E09_RS15030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8E09_RS15075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8E09_RS15080	COG0489	protein tyrosine kinase activity
G8E09_RS15090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8E09_RS15090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8E09_RS15125	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G8E09_RS15130	COG2081	HI0933 family
G8E09_RS15140	COG0668	transmembrane transport
G8E09_RS15160	COG0583	DNA-binding transcription factor activity
G8E09_RS15180	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8E09_RS15185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G8E09_RS15215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G8E09_RS15240	COG2199	diguanylate cyclase activity
G8E09_RS15250	COG2205	protein histidine kinase activity
G8E09_RS15255	COG0745	RESPONSE REGULATOR receiver
G8E09_RS15270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8E09_RS15275	COG0384	phenazine biosynthesis protein PhzF
G8E09_RS15325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8E09_RS15340	COG0583	DNA-binding transcription factor activity
G8E09_RS15360	COG1473	amidohydrolase
G8E09_RS15390	COG0583	DNA-binding transcription factor activity
G8E09_RS15405	COG0583	DNA-binding transcription factor activity
G8E09_RS15410	COG1053	succinate dehydrogenase
G8E09_RS15425	COG1309	transcriptional regulator
G8E09_RS15435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8E09_RS15440	COG2814	Major facilitator Superfamily
G8E09_RS15445	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS15450	COG0583	DNA-binding transcription factor activity
G8E09_RS15455	COG1063	alcohol dehydrogenase
G8E09_RS15485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G8E09_RS15490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G8E09_RS15515	COG2132	Multicopper oxidase
G8E09_RS15525	COG0561	phosphatase activity
G8E09_RS15530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G8E09_RS15540	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G8E09_RS15555	COG1214	PFAM Peptidase M22, glycoprotease
G8E09_RS15615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G8E09_RS15620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G8E09_RS15625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G8E09_RS15685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8E09_RS15695	COG1846	Transcriptional regulator
G8E09_RS15700	COG1764	response to oxidative stress
G8E09_RS15740	COG0037	tRNA processing
G8E09_RS15750	COG0248	Ppx GppA phosphatase
G8E09_RS15780	COG0072	phenylalanine-tRNA ligase activity
G8E09_RS15810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G8E09_RS15825	COG1238	metal cluster binding
G8E09_RS15830	COG0625	glutathione transferase activity
G8E09_RS15845	COG0318	PFAM AMP-dependent synthetase and ligase
G8E09_RS15850	COG3028	Belongs to the UPF0307 family
G8E09_RS15855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8E09_RS15875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8E09_RS15880	COG0617	tRNA 3'-terminal CCA addition
G8E09_RS15885	COG1555	photosystem II stabilization
G8E09_RS15890	COG3956	TIGRFAM MazG family protein
G8E09_RS15900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8E09_RS15915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8E09_RS15920	COG2205	protein histidine kinase activity
G8E09_RS15920	COG5002	protein histidine kinase activity
G8E09_RS15920	COG0784	Response regulator, receiver
G8E09_RS15925	COG1024	Enoyl-CoA hydratase
G8E09_RS15930	COG2084	Dehydrogenase
G8E09_RS15935	COG3622	Belongs to the hyi family
G8E09_RS15965	COG0697	spore germination
G8E09_RS15975	COG2814	Major facilitator Superfamily
G8E09_RS16000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G8E09_RS16025	COG3501	Rhs element vgr protein
G8E09_RS16105	COG4772	TonB-dependent receptor
G8E09_RS16115	COG3340	Belongs to the peptidase S51 family
G8E09_RS16145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8E09_RS16155	COG0583	DNA-binding transcription factor activity
G8E09_RS16165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G8E09_RS16175	COG0084	hydrolase, TatD family'
G8E09_RS16190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G8E09_RS16210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G8E09_RS16215	COG0440	acetolactate synthase activity
G8E09_RS16220	COG0028	Belongs to the TPP enzyme family
G8E09_RS16240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8E09_RS16245	COG0577	efflux transmembrane transporter activity
G8E09_RS16245	COG1136	(ABC) transporter
G8E09_RS16265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G8E09_RS16270	COG1162	GTPase activity
G8E09_RS16280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G8E09_RS16300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8E09_RS16305	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS16345	COG2986	histidine ammonia-lyase
G8E09_RS16355	COG1216	Glycosyl transferase, family 2
G8E09_RS16370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8E09_RS16395	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8E09_RS16415	COG1426	Protein conserved in bacteria
G8E09_RS16450	COG0793	Belongs to the peptidase S41A family
G8E09_RS16465	COG2267	carboxylic ester hydrolase activity
G8E09_RS16475	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS16480	COG3265	gluconokinase activity
G8E09_RS16490	COG0800	Aldolase
G8E09_RS16505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G8E09_RS16510	COG0857	belongs to the CobB CobQ family
G8E09_RS16510	COG0280	phosphate acetyltransferase
G8E09_RS16515	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G8E09_RS16515	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G8E09_RS16535	COG0740	serine-type endopeptidase activity
G8E09_RS16545	COG4774	siderophore transport
G8E09_RS16555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G8E09_RS16565	COG2813	Specifically methylates the guanine in position
G8E09_RS16565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8E09_RS16660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G8E09_RS16685	COG0251	oxidation-reduction process
G8E09_RS16700	COG0583	DNA-binding transcription factor activity
G8E09_RS16720	COG0235	Class ii aldolase
G8E09_RS16725	COG0477	Major facilitator Superfamily
G8E09_RS16735	COG1012	belongs to the aldehyde dehydrogenase family
G8E09_RS16745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8E09_RS16750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8E09_RS16755	COG1113	amino acid transport
G8E09_RS16765	COG1522	sequence-specific DNA binding
G8E09_RS16770	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G8E09_RS16780	COG2207	Transcriptional regulator
G8E09_RS16800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8E09_RS16845	COG0788	formyltetrahydrofolate deformylase activity
G8E09_RS16870	COG4651	solute:proton antiporter activity
G8E09_RS16870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G8E09_RS16890	COG0724	RNA recognition motif
G8E09_RS16895	COG0210	DNA helicase
G8E09_RS16920	COG1733	regulation of RNA biosynthetic process
G8E09_RS16930	COG2900	Belongs to the SlyX family
G8E09_RS16945	COG1560	Kdo2-lipid A biosynthetic process
G8E09_RS16955	COG1301	dicarboxylic acid transport
G8E09_RS17010	COG0473	3-isopropylmalate dehydrogenase activity
G8E09_RS17035	COG0583	DNA-binding transcription factor activity
G8E09_RS17075	COG0583	DNA-binding transcription factor activity
G8E09_RS17085	COG0625	glutathione transferase activity
G8E09_RS17090	COG2378	regulation of single-species biofilm formation
G8E09_RS17095	COG0546	phosphoglycolate phosphatase activity
G8E09_RS17110	COG1530	ribonuclease E activity
G8E09_RS17115	COG0318	PFAM AMP-dependent synthetase and ligase
G8E09_RS17130	COG0583	DNA-binding transcription factor activity
G8E09_RS17135	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS17140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8E09_RS17150	COG0534	Mate efflux family protein
G8E09_RS17165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8E09_RS17190	COG0493	'glutamate synthase
G8E09_RS17200	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G8E09_RS17205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8E09_RS17220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8E09_RS17230	COG0644	oxidoreductase
G8E09_RS17230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G8E09_RS17245	COG4535	Mg2 and Co2 transporter CorC
G8E09_RS17255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8E09_RS17275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G8E09_RS17285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G8E09_RS17295	COG0484	heat shock protein binding
G8E09_RS17300	COG0789	Transcriptional regulator
G8E09_RS17305	COG0598	Magnesium transport protein CorA
G8E09_RS17310	COG1185	polyribonucleotide nucleotidyltransferase activity
G8E09_RS17325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8E09_RS17330	COG1074	ATP-dependent DNA helicase activity
G8E09_RS17335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G8E09_RS17355	COG2226	methyltransferase
G8E09_RS17365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8E09_RS17380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G8E09_RS17395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G8E09_RS17395	COG2111	Na H antiporter
G8E09_RS17400	COG1006	Multisubunit Na H antiporter MnhC subunit
G8E09_RS17405	COG0651	ATP synthesis coupled electron transport
G8E09_RS17415	COG2212	antiporter activity
G8E09_RS17425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G8E09_RS17435	COG0195	Participates in both transcription termination and antitermination
G8E09_RS17485	COG0237	dephospho-CoA kinase activity
G8E09_RS17495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8E09_RS17510	COG0497	DNA recombination
G8E09_RS17520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G8E09_RS17555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8E09_RS17555	COG2169	Transcriptional regulator
G8E09_RS17560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8E09_RS17605	COG0326	Molecular chaperone. Has ATPase activity
G8E09_RS17625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G8E09_RS17640	COG0326	Molecular chaperone. Has ATPase activity
G8E09_RS17655	COG2056	Na+-H+ antiporter family
G8E09_RS17725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G8E09_RS17755	COG0546	phosphoglycolate phosphatase activity
G8E09_RS17760	COG1716	ATPase activity
G8E09_RS17805	COG0181	hydroxymethylbilane synthase activity
G8E09_RS17815	COG3275	phosphorelay sensor kinase activity
G8E09_RS17835	COG1538	Outer membrane efflux protein
G8E09_RS17845	COG0697	spore germination
G8E09_RS17865	COG0494	nUDIX hydrolase
G8E09_RS17870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G8E09_RS17875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G8E09_RS17880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8E09_RS17885	COG0772	Belongs to the SEDS family
G8E09_RS17910	COG4974	Belongs to the 'phage' integrase family
G8E09_RS17915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8E09_RS17925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G8E09_RS17935	COG2197	response regulator
G8E09_RS17950	COG0793	Belongs to the peptidase S41A family
G8E09_RS17955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G8E09_RS17960	COG0795	lipopolysaccharide-transporting ATPase activity
G8E09_RS18000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8E09_RS18000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8E09_RS18010	COG0004	ammonium transporteR
G8E09_RS18015	COG0347	Belongs to the P(II) protein family
G8E09_RS18025	COG0606	chelatase, subunit chli
G8E09_RS18030	COG0431	NADPH-dependent FMN reductase
G8E09_RS18035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8E09_RS18040	COG0235	Class ii aldolase
G8E09_RS18045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8E09_RS18065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G8E09_RS18080	COG0318	PFAM AMP-dependent synthetase and ligase
G8E09_RS18090	COG0477	Major facilitator Superfamily
G8E09_RS18095	COG2860	membrane
G8E09_RS18105	COG1253	flavin adenine dinucleotide binding
G8E09_RS18115	COG2814	Major facilitator Superfamily
G8E09_RS18125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8E09_RS18135	COG0745	RESPONSE REGULATOR receiver
G8E09_RS18140	COG2205	protein histidine kinase activity
G8E09_RS18145	COG4452	Inner membrane protein CreD
G8E09_RS18185	COG0655	NAD(P)H dehydrogenase (quinone) activity
G8E09_RS18200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8E09_RS18230	COG1309	transcriptional regulator
G8E09_RS18265	COG0758	DNA mediated transformation
G8E09_RS18275	COG0697	spore germination
G8E09_RS18280	COG1309	transcriptional regulator
G8E09_RS18295	COG0386	Belongs to the glutathione peroxidase family
G8E09_RS18310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G8E09_RS18320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G8E09_RS18360	COG1121	(ABC) transporter
G8E09_RS18365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8E09_RS18370	COG1280	lysine exporter protein (LysE YggA)
G8E09_RS18375	COG2837	iron assimilation
G8E09_RS18380	COG0281	malic enzyme
G8E09_RS18425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8E09_RS18425	COG0519	Catalyzes the synthesis of GMP from XMP
G8E09_RS18430	COG4399	Belongs to the UPF0754 family
G8E09_RS18435	COG2259	Doxx family
G8E09_RS18440	COG0586	Pfam SNARE associated Golgi protein
G8E09_RS18455	COG1192	Involved in chromosome partitioning
G8E09_RS18465	COG0271	Belongs to the BolA IbaG family
G8E09_RS18505	COG3321	synthase
G8E09_RS18505	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G8E09_RS18505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8E09_RS18505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G8E09_RS18510	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS18515	COG0318	PFAM AMP-dependent synthetase and ligase
G8E09_RS18520	COG2197	response regulator
G8E09_RS18530	COG3916	Acyl-homoserine-lactone synthase
G8E09_RS18535	COG0477	Major facilitator Superfamily
G8E09_RS18540	COG1024	Enoyl-CoA hydratase
G8E09_RS18545	COG1024	Enoyl-CoA hydratase
G8E09_RS18550	COG1960	acyl-CoA dehydrogenase activity
G8E09_RS18555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8E09_RS18575	COG1113	amino acid transport
G8E09_RS18580	COG1113	amino acid transport
G8E09_RS18585	COG0251	oxidation-reduction process
G8E09_RS18625	COG0564	pseudouridine synthase activity
G8E09_RS18670	COG1051	belongs to the nudix hydrolase family
G8E09_RS18690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G8E09_RS18705	COG1802	Transcriptional regulator
G8E09_RS18715	COG1448	Aminotransferase
G8E09_RS18720	COG0277	FAD linked oxidase domain protein
G8E09_RS18730	COG2186	Transcriptional regulator
G8E09_RS18740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8E09_RS18745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8E09_RS18760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G8E09_RS18770	COG0110	maltose O-acetyltransferase activity
G8E09_RS18775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8E09_RS18790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G8E09_RS18825	COG1083	cytidylyl-transferase
G8E09_RS18830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G8E09_RS18840	COG2089	acid synthase
G8E09_RS18845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G8E09_RS18850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G8E09_RS18860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G8E09_RS18865	COG1596	polysaccharide export
G8E09_RS18890	COG0728	peptidoglycan biosynthetic process
G8E09_RS18895	COG3023	N-Acetylmuramoyl-L-alanine amidase
G8E09_RS18950	COG0546	phosphoglycolate phosphatase activity
G8E09_RS18955	COG1028	Short-chain dehydrogenase reductase Sdr
G8E09_RS18970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G8E09_RS18970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G8E09_RS18975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E09_RS18980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8E09_RS18985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8E09_RS18990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8E09_RS18995	COG1116	anion transmembrane transporter activity
G8E09_RS19000	COG1309	transcriptional regulator
G8E09_RS19005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8E09_RS19015	COG0196	riboflavin kinase activity
G8E09_RS19020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G8E09_RS19030	COG1047	Peptidyl-prolyl cis-trans
G8E09_RS19070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G8E09_RS19125	COG2951	lytic endotransglycosylase activity
G8E09_RS19130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G8E09_RS19145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8E09_RS19155	COG0671	phosphoesterase, PA-phosphatase related
G8E09_RS19160	COG0861	Integral membrane protein TerC family
G8E09_RS19170	COG0754	glutathionylspermidine amidase activity
G8E09_RS19180	COG0402	S-adenosylhomocysteine deaminase activity
G8E09_RS19195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8E09_RS19200	COG1230	cation diffusion facilitator family transporter
G8E09_RS19215	COG0706	membrane insertase activity
G8E09_RS19280	COG2026	Addiction module toxin, RelE StbE family
G8E09_RS19325	COG1192	Involved in chromosome partitioning
G8E09_RS19570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G8E09_RS19670	COG3504	Conjugal transfer protein
G8E09_RS19675	COG2948	multi-organism process
G8E09_RS19725	COG4683	PFAM Phage derived protein Gp49-like (DUF891)