locus-tag	class	description
E8E07_RS00010	COG0592	DNA-directed DNA polymerase activity
E8E07_RS00020	COG0187	DNA topoisomerase II activity
E8E07_RS00035	COG0488	(ABC) transporter
E8E07_RS00060	COG0596	Alpha beta hydrolase
E8E07_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E8E07_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E8E07_RS00105	COG0625	glutathione transferase activity
E8E07_RS00115	COG0733	neurotransmitter:sodium symporter activity
E8E07_RS00155	COG2233	PERMEase
E8E07_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8E07_RS00205	COG2814	Major facilitator Superfamily
E8E07_RS00210	COG0656	L-ascorbic acid biosynthetic process
E8E07_RS00215	COG0583	DNA-binding transcription factor activity
E8E07_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8E07_RS00235	COG1064	alcohol dehydrogenase
E8E07_RS00240	COG2818	Glycosylase
E8E07_RS00255	COG1194	a g-specific adenine glycosylase
E8E07_RS00270	COG5487	UPF0391 membrane protein
E8E07_RS00275	COG2983	Belongs to the UPF0260 family
E8E07_RS00280	COG2133	pyrroloquinoline quinone binding
E8E07_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E8E07_RS00290	COG2116	formate transmembrane transporter activity
E8E07_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8E07_RS00315	COG1335	isochorismatase
E8E07_RS00320	COG0385	Bile acid
E8E07_RS00325	COG0534	Mate efflux family protein
E8E07_RS00330	COG1683	Conserved Protein
E8E07_RS00345	COG0346	lactoylglutathione lyase activity
E8E07_RS00350	COG0625	glutathione transferase activity
E8E07_RS00360	COG1113	amino acid transport
E8E07_RS00370	COG0523	cobalamin synthesis protein
E8E07_RS00380	COG2188	Transcriptional regulator
E8E07_RS00410	COG0010	Belongs to the arginase family
E8E07_RS00420	COG0546	phosphoglycolate phosphatase activity
E8E07_RS00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E8E07_RS00430	COG1280	lysine exporter protein (LysE YggA)
E8E07_RS00435	COG3293	Transposase
E8E07_RS00490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E8E07_RS00500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E8E07_RS00505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E8E07_RS00610	COG0436	Aminotransferase
E8E07_RS00615	COG2733	membrane
E8E07_RS00630	COG2918	glutathione biosynthetic process
E8E07_RS00670	COG3150	esterase
E8E07_RS00680	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E8E07_RS00690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8E07_RS00700	COG2233	PERMEase
E8E07_RS00705	COG2351	hydroxyisourate hydrolase activity
E8E07_RS00740	COG3706	GGDEF domain
E8E07_RS00755	COG1393	Belongs to the ArsC family
E8E07_RS00760	COG0708	Exodeoxyribonuclease III
E8E07_RS00785	COG0189	ligase activity
E8E07_RS00805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E8E07_RS00815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E8E07_RS00830	COG4942	peptidase
E8E07_RS00840	COG0508	dehydrogenase complex catalyzes the overall conversion of
E8E07_RS00850	COG2119	membrane
E8E07_RS00855	COG4774	siderophore transport
E8E07_RS00860	COG0426	domain, Protein
E8E07_RS00860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E8E07_RS00885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E8E07_RS00910	COG1902	pentaerythritol trinitrate reductase activity
E8E07_RS00915	COG1519	Transferase
E8E07_RS00920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E8E07_RS00925	COG0668	transmembrane transport
E8E07_RS00935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8E07_RS00940	COG1335	isochorismatase
E8E07_RS00945	COG1522	sequence-specific DNA binding
E8E07_RS00970	COG0784	Response regulator, receiver
E8E07_RS00970	COG2205	protein histidine kinase activity
E8E07_RS00970	COG2198	Histidine kinase
E8E07_RS00975	COG3162	membrane
E8E07_RS00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8E07_RS00990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8E07_RS01010	COG1309	transcriptional regulator
E8E07_RS01030	COG4221	oxidoreductase activity
E8E07_RS01040	COG0351	phosphomethylpyrimidine kinase
E8E07_RS01040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E8E07_RS01040	COG0352	thiamine-phosphate diphosphorylase activity
E8E07_RS01050	COG2814	Major facilitator Superfamily
E8E07_RS01065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E8E07_RS01075	COG1113	amino acid transport
E8E07_RS01085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8E07_RS01090	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS01100	COG1335	isochorismatase
E8E07_RS01165	COG2814	Major facilitator Superfamily
E8E07_RS01170	COG0583	DNA-binding transcription factor activity
E8E07_RS01195	COG0667	Aldo Keto reductase
E8E07_RS01230	COG1733	regulation of RNA biosynthetic process
E8E07_RS01240	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8E07_RS01250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E8E07_RS01255	COG2207	Transcriptional regulator
E8E07_RS01315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E8E07_RS01330	COG2329	Antibiotic biosynthesis monooxygenase
E8E07_RS01345	COG1132	(ABC) transporter
E8E07_RS01365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E8E07_RS01395	COG0427	acetyl-CoA hydrolase
E8E07_RS01420	COG0659	secondary active sulfate transmembrane transporter activity
E8E07_RS01425	COG4221	oxidoreductase activity
E8E07_RS01430	COG2873	o-acetylhomoserine
E8E07_RS01435	COG0488	(ABC) transporter
E8E07_RS01520	COG0833	amino acid
E8E07_RS01565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E8E07_RS01570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E8E07_RS01585	COG2226	methyltransferase
E8E07_RS01635	COG0070	glutamate synthase
E8E07_RS01635	COG0069	glutamate synthase activity
E8E07_RS01635	COG0067	glutamate synthase
E8E07_RS01640	COG0493	'glutamate synthase
E8E07_RS01650	COG1704	LemA family
E8E07_RS01655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E8E07_RS01670	COG3307	-O-antigen
E8E07_RS01695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E8E07_RS01710	COG0194	GDP metabolic process
E8E07_RS01760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E8E07_RS01770	COG0335	large ribosomal subunit rRNA binding
E8E07_RS01780	COG5380	lipid catabolic process
E8E07_RS01785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E8E07_RS01800	COG5006	permease, DMT superfamily
E8E07_RS01805	COG5006	permease, DMT superfamily
E8E07_RS01810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8E07_RS01815	COG0277	FAD linked oxidase domain protein
E8E07_RS01825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E8E07_RS01830	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8E07_RS01845	COG1289	transmembrane transporter activity
E8E07_RS01855	COG3293	Transposase
E8E07_RS01860	COG0628	permease
E8E07_RS01865	COG1192	Involved in chromosome partitioning
E8E07_RS01895	COG0833	amino acid
E8E07_RS01900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E8E07_RS01905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E8E07_RS01915	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS01955	COG0583	DNA-binding transcription factor activity
E8E07_RS01980	COG0752	glycyl-tRNA synthetase alpha subunit
E8E07_RS02005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E8E07_RS02005	COG0617	tRNA 3'-terminal CCA addition
E8E07_RS02005	COG0517	IMP dehydrogenase activity
E8E07_RS02010	COG1983	PspC domain protein
E8E07_RS02020	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS02035	COG0408	coproporphyrinogen oxidase activity
E8E07_RS02055	COG0513	Belongs to the DEAD box helicase family
E8E07_RS02065	COG1127	ABC transporter
E8E07_RS02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8E07_RS02080	COG2854	intermembrane phospholipid transfer
E8E07_RS02090	COG0598	Magnesium transport protein CorA
E8E07_RS02100	COG0494	nUDIX hydrolase
E8E07_RS02105	COG1040	competence protein
E8E07_RS02110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E8E07_RS02130	COG1946	Acyl-CoA thioesterase
E8E07_RS02135	COG1301	dicarboxylic acid transport
E8E07_RS02150	COG1959	2 iron, 2 sulfur cluster binding
E8E07_RS02155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8E07_RS02155	COG1017	nitric oxide dioxygenase activity
E8E07_RS02165	COG0433	COG0433 Predicted ATPase
E8E07_RS02170	COG0626	cystathionine gamma-synthase activity
E8E07_RS02185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E8E07_RS02190	COG0088	Forms part of the polypeptide exit tunnel
E8E07_RS02325	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS02330	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E8E07_RS02360	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E8E07_RS02365	COG0339	signal peptide processing
E8E07_RS02370	COG0557	exoribonuclease II activity
E8E07_RS02420	COG0179	Fumarylacetoacetate (FAA) hydrolase
E8E07_RS02425	COG1295	ribonuclease BN
E8E07_RS02450	COG3293	Transposase
E8E07_RS02465	COG1702	phosphate starvation-inducible protein PhoH
E8E07_RS02475	COG0739	heme binding
E8E07_RS02475	COG1196	nuclear chromosome segregation
E8E07_RS02475	COG0741	lytic transglycosylase activity
E8E07_RS02505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E8E07_RS02510	COG1183	phosphatidylcholine synthase activity
E8E07_RS02555	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS02560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8E07_RS02565	COG1309	transcriptional regulator
E8E07_RS02580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E8E07_RS02585	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS02625	COG2969	positive regulation of protein catabolic process
E8E07_RS02635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E8E07_RS02640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E8E07_RS02645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E8E07_RS02650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E8E07_RS02655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E8E07_RS02675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E8E07_RS02685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E8E07_RS02690	COG1408	metallophosphoesterase
E8E07_RS02695	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E8E07_RS02695	COG2885	chlorophyll binding
E8E07_RS02700	COG2199	diguanylate cyclase activity
E8E07_RS02740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8E07_RS02765	COG1607	acyl-coa hydrolase
E8E07_RS02800	COG2350	Protein conserved in bacteria
E8E07_RS02815	COG3781	membrane
E8E07_RS02825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E8E07_RS02830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E8E07_RS02840	COG1862	Preprotein translocase
E8E07_RS02865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E8E07_RS02885	COG0726	polysaccharide deacetylase
E8E07_RS02890	COG0463	Glycosyl transferase, family 2
E8E07_RS02895	COG0438	transferase activity, transferring glycosyl groups
E8E07_RS02915	COG3293	Transposase
E8E07_RS02965	COG0625	glutathione transferase activity
E8E07_RS02970	COG0583	DNA-binding transcription factor activity
E8E07_RS02975	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS02980	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS02990	COG2205	protein histidine kinase activity
E8E07_RS02995	COG0745	RESPONSE REGULATOR receiver
E8E07_RS03005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E8E07_RS03025	COG2096	Adenosyltransferase
E8E07_RS03030	COG4206	TonB-dependent receptor
E8E07_RS03075	COG0285	dihydrofolate synthase activity
E8E07_RS03095	COG0450	alkyl hydroperoxide reductase
E8E07_RS03110	COG0477	Major facilitator Superfamily
E8E07_RS03115	COG1272	protein, Hemolysin III
E8E07_RS03125	COG3293	Transposase
E8E07_RS03135	COG2153	protein acetylation
E8E07_RS03155	COG0183	Belongs to the thiolase family
E8E07_RS03160	COG2207	Transcriptional regulator
E8E07_RS03180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8E07_RS03200	COG0183	Belongs to the thiolase family
E8E07_RS03210	COG2885	chlorophyll binding
E8E07_RS03210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E8E07_RS03215	COG1690	Belongs to the RtcB family
E8E07_RS03220	COG0833	amino acid
E8E07_RS03230	COG2233	PERMEase
E8E07_RS03235	COG1217	gtp-binding protein TYPA
E8E07_RS03265	COG2094	Belongs to the DNA glycosylase MPG family
E8E07_RS03270	COG4772	TonB-dependent receptor
E8E07_RS03275	COG1902	pentaerythritol trinitrate reductase activity
E8E07_RS03290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E8E07_RS03295	COG0354	folic acid binding
E8E07_RS03310	COG3189	MarR family transcriptional regulator
E8E07_RS03315	COG2824	Alkylphosphonate utilization operon protein PhnA
E8E07_RS03320	COG3422	double-strand break repair
E8E07_RS03360	COG0840	transmembrane signaling receptor activity
E8E07_RS03385	COG5510	response to toxic substance
E8E07_RS03395	COG2832	Protein of unknown function (DUF454)
E8E07_RS03400	COG1376	ErfK ybiS ycfS ynhG family protein
E8E07_RS03440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E8E07_RS03450	COG1289	transmembrane transporter activity
E8E07_RS03455	COG2814	Major facilitator Superfamily
E8E07_RS03480	COG1115	amino acid carrier protein
E8E07_RS03485	COG1752	Esterase of the alpha-beta hydrolase superfamily
E8E07_RS03490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E8E07_RS03495	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E8E07_RS03500	COG3590	peptidase
E8E07_RS03530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8E07_RS03540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8E07_RS03545	COG1077	Cell shape determining protein MreB Mrl
E8E07_RS03550	COG1792	Involved in formation and maintenance of cell shape
E8E07_RS03555	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E8E07_RS03560	COG0424	maF-like protein
E8E07_RS03565	COG1530	ribonuclease E activity
E8E07_RS03575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E8E07_RS03595	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8E07_RS03620	COG2207	Transcriptional regulator
E8E07_RS03645	COG1113	amino acid transport
E8E07_RS03650	COG2828	Protein conserved in bacteria
E8E07_RS03655	COG0142	geranyltranstransferase activity
E8E07_RS03660	COG2315	Protein conserved in bacteria
E8E07_RS03675	COG1752	Esterase of the alpha-beta hydrolase superfamily
E8E07_RS03700	COG2194	sulfuric ester hydrolase activity
E8E07_RS03705	COG0745	RESPONSE REGULATOR receiver
E8E07_RS03710	COG0642	Histidine kinase
E8E07_RS03720	COG0004	ammonium transporteR
E8E07_RS03730	COG0583	DNA-binding transcription factor activity
E8E07_RS03755	COG0525	valine-tRNA ligase activity
E8E07_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS03775	COG0393	Putative heavy-metal-binding
E8E07_RS03780	COG0393	Putative heavy-metal-binding
E8E07_RS03785	COG1538	Outer membrane efflux protein
E8E07_RS03795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8E07_RS03800	COG0671	phosphoesterase, PA-phosphatase related
E8E07_RS03825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E8E07_RS03840	COG1648	precorrin-2 dehydrogenase activity
E8E07_RS03840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E8E07_RS03845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E8E07_RS03860	COG0531	amino acid
E8E07_RS03875	COG0321	lipoyl(octanoyl) transferase activity
E8E07_RS03880	COG2921	Belongs to the UPF0250 family
E8E07_RS03935	COG2009	succinate dehydrogenase
E8E07_RS03940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E8E07_RS03945	COG1053	succinate dehydrogenase
E8E07_RS03950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8E07_RS03975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8E07_RS03995	COG2354	Protein conserved in bacteria
E8E07_RS04000	COG2321	neutral zinc metallopeptidase
E8E07_RS04030	COG2843	Capsule synthesis protein
E8E07_RS04050	COG0589	response to stress
E8E07_RS04065	COG1309	transcriptional regulator
E8E07_RS04080	COG0505	Belongs to the CarA family
E8E07_RS04115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8E07_RS04120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E8E07_RS04175	COG0477	Major facilitator Superfamily
E8E07_RS04180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E8E07_RS04195	COG1597	lipid kinase activity
E8E07_RS04200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E8E07_RS04225	COG0584	glycerophosphoryl diester phosphodiesterase
E8E07_RS04245	COG0741	lytic transglycosylase activity
E8E07_RS04270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E8E07_RS04290	COG0583	DNA-binding transcription factor activity
E8E07_RS04325	COG0406	alpha-ribazole phosphatase activity
E8E07_RS04350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8E07_RS04360	COG0778	Nitroreductase
E8E07_RS04380	COG1929	Belongs to the glycerate kinase type-1 family
E8E07_RS04385	COG0243	molybdopterin cofactor binding
E8E07_RS04390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E8E07_RS04395	COG3339	Conserved Protein
E8E07_RS04405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E8E07_RS04420	COG1115	amino acid carrier protein
E8E07_RS04425	COG1113	amino acid transport
E8E07_RS04435	COG0019	diaminopimelate decarboxylase activity
E8E07_RS04445	COG1280	lysine exporter protein (LysE YggA)
E8E07_RS04450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E8E07_RS04480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8E07_RS04510	COG4591	ABC-type transport system involved in lipoprotein release permease component
E8E07_RS04515	COG1136	(ABC) transporter
E8E07_RS04525	COG3328	transposase activity
E8E07_RS04540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E8E07_RS04540	COG0616	signal peptide processing
E8E07_RS04545	COG0596	Alpha beta hydrolase
E8E07_RS04550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E8E07_RS04560	COG0628	permease
E8E07_RS04600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E8E07_RS04620	COG0823	Involved in the tonB-independent uptake of proteins
E8E07_RS04640	COG0824	Thioesterase
E8E07_RS04645	COG1473	amidohydrolase
E8E07_RS04665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E8E07_RS04665	COG0047	phosphoribosylformylglycinamidine synthase activity
E8E07_RS04670	COG2814	Major facilitator Superfamily
E8E07_RS04680	COG1024	Enoyl-CoA hydratase
E8E07_RS04685	COG1056	cytidyltransferase-related domain
E8E07_RS04685	COG1051	belongs to the nudix hydrolase family
E8E07_RS04700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E8E07_RS04715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E8E07_RS04735	COG4372	Transposase
E8E07_RS04750	COG0583	DNA-binding transcription factor activity
E8E07_RS04755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E8E07_RS04760	COG4208	sulfate ABC transporter
E8E07_RS04765	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E8E07_RS04775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E8E07_RS04780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E8E07_RS04785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E8E07_RS04805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8E07_RS04815	COG0481	GTPase activity
E8E07_RS04820	COG0681	Belongs to the peptidase S26 family
E8E07_RS04830	COG0571	ribonuclease III activity
E8E07_RS04835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E8E07_RS04845	COG1381	Involved in DNA repair and RecF pathway recombination
E8E07_RS04850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E8E07_RS04860	COG4221	oxidoreductase activity
E8E07_RS04890	COG0436	Aminotransferase
E8E07_RS04910	COG0556	nucleotide-excision repair
E8E07_RS04920	COG2962	Rard protein
E8E07_RS04965	COG2070	2-Nitropropane dioxygenase
E8E07_RS04980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E8E07_RS04995	COG1215	transferase activity, transferring glycosyl groups
E8E07_RS05010	COG0415	Belongs to the DNA photolyase family
E8E07_RS05020	COG1252	NADH dehydrogenase
E8E07_RS05025	COG1686	Belongs to the peptidase S11 family
E8E07_RS05040	COG1187	pseudouridine synthase activity
E8E07_RS05055	COG0477	Major facilitator Superfamily
E8E07_RS05060	COG0583	DNA-binding transcription factor activity
E8E07_RS05065	COG1823	symporter activity
E8E07_RS05075	COG0612	Peptidase, M16
E8E07_RS05100	COG0352	thiamine-phosphate diphosphorylase activity
E8E07_RS05135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8E07_RS05150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8E07_RS05155	COG0076	glutamate decarboxylase activity
E8E07_RS05165	COG1522	sequence-specific DNA binding
E8E07_RS05170	COG3961	Belongs to the TPP enzyme family
E8E07_RS05175	COG1113	amino acid transport
E8E07_RS05180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E8E07_RS05185	COG0573	inorganic phosphate transmembrane transporter activity
E8E07_RS05195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8E07_RS05200	COG0616	signal peptide processing
E8E07_RS05235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E8E07_RS05240	COG1686	Belongs to the peptidase S11 family
E8E07_RS05265	COG0583	DNA-binding transcription factor activity
E8E07_RS05270	COG1067	ATP-dependent peptidase activity
E8E07_RS05310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E8E07_RS05315	COG1966	Carbon starvation protein
E8E07_RS05320	COG2879	small protein
E8E07_RS05330	COG0583	DNA-binding transcription factor activity
E8E07_RS05335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8E07_RS05345	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS05350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8E07_RS05355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8E07_RS05355	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E8E07_RS05420	COG1741	Belongs to the pirin family
E8E07_RS05435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E8E07_RS05440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8E07_RS05445	COG4605	iron ion homeostasis
E8E07_RS05450	COG4604	ABC transporter, ATP-binding protein
E8E07_RS05455	COG4607	ABC-type enterochelin transport system periplasmic component
E8E07_RS05460	COG4774	siderophore transport
E8E07_RS05470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E8E07_RS05475	COG1021	2,3-dihydroxybenzoate-AMP ligase
E8E07_RS05480	COG1535	isochorismatase
E8E07_RS05480	COG3433	isochorismatase activity
E8E07_RS05495	COG1132	(ABC) transporter
E8E07_RS05500	COG1132	(ABC) transporter
E8E07_RS05505	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E8E07_RS05510	COG2977	Belongs to the P-Pant transferase superfamily
E8E07_RS05515	COG1169	isochorismate synthase
E8E07_RS05535	COG3739	integral membrane protein
E8E07_RS05555	COG0302	gtp cyclohydrolase
E8E07_RS05565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E8E07_RS05590	COG0512	Glutamine amidotransferase of anthranilate synthase
E8E07_RS05815	COG3561	AntA/AntB antirepressor
E8E07_RS05955	COG3293	Transposase
E8E07_RS05960	COG0582	viral genome integration into host DNA
E8E07_RS05975	COG0174	glutamine synthetase
E8E07_RS05985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E8E07_RS06020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E8E07_RS06025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E8E07_RS06030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8E07_RS06050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E8E07_RS06055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E8E07_RS06060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E8E07_RS06075	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS06080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E8E07_RS06085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8E07_RS06095	COG2223	nitrite transmembrane transporter activity
E8E07_RS06105	COG0024	Methionine aminopeptidase
E8E07_RS06110	COG0052	Belongs to the universal ribosomal protein uS2 family
E8E07_RS06125	COG2207	Transcriptional regulator
E8E07_RS06150	COG2951	lytic endotransglycosylase activity
E8E07_RS06155	COG0772	Belongs to the SEDS family
E8E07_RS06170	COG0842	Transport permease protein
E8E07_RS06175	COG1131	(ABC) transporter
E8E07_RS06185	COG3293	Transposase
E8E07_RS06225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8E07_RS06235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8E07_RS06240	COG4215	(ABC) transporter
E8E07_RS06245	COG4160	amino acid transport
E8E07_RS06250	COG4598	ABC transporter
E8E07_RS06260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8E07_RS06265	COG0826	peptidase U32
E8E07_RS06270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8E07_RS06275	COG0384	phenazine biosynthesis protein PhzF
E8E07_RS06285	COG1720	tRNA m6t6A37 methyltransferase activity
E8E07_RS06295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E8E07_RS06310	COG0642	Histidine kinase
E8E07_RS06320	COG0494	nUDIX hydrolase
E8E07_RS06330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E8E07_RS06335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E8E07_RS06340	COG3139	Protein of unknown function (DUF1315)
E8E07_RS06355	COG1301	dicarboxylic acid transport
E8E07_RS06360	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS06380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E8E07_RS06390	COG2195	Cleaves the N-terminal amino acid of tripeptides
E8E07_RS06410	COG1690	Belongs to the RtcB family
E8E07_RS06415	COG1234	tRNA 3'-trailer cleavage
E8E07_RS06420	COG4650	regulator
E8E07_RS06450	COG2363	Small membrane protein
E8E07_RS06470	COG0513	Belongs to the DEAD box helicase family
E8E07_RS06480	COG0778	Nitroreductase
E8E07_RS06510	COG1286	toxin biosynthetic process
E8E07_RS06535	COG4783	chaperone-mediated protein folding
E8E07_RS06540	COG1610	YqeY-like protein
E8E07_RS06570	COG2815	serine threonine protein kinase
E8E07_RS06570	COG0515	serine threonine protein kinase
E8E07_RS06595	COG1278	Cold shock
E8E07_RS06610	COG3243	poly(R)-hydroxyalkanoic acid synthase
E8E07_RS06615	COG0786	glutamate:sodium symporter activity
E8E07_RS06620	COG0475	glutathione-regulated potassium exporter activity
E8E07_RS06620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E8E07_RS06630	COG1309	transcriptional regulator
E8E07_RS06640	COG2985	domain, Protein
E8E07_RS06645	COG3293	Transposase
E8E07_RS06660	COG2995	paraquat-inducible protein a
E8E07_RS06665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E8E07_RS06665	COG3008	intermembrane lipid transfer
E8E07_RS06675	COG2351	hydroxyisourate hydrolase activity
E8E07_RS06715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E8E07_RS06725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E8E07_RS06730	COG0642	Histidine kinase
E8E07_RS06735	COG0745	RESPONSE REGULATOR receiver
E8E07_RS06750	COG1794	racemase activity, acting on amino acids and derivatives
E8E07_RS06770	COG2814	Major facilitator Superfamily
E8E07_RS06795	COG1301	dicarboxylic acid transport
E8E07_RS06805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8E07_RS06810	COG2011	ABC-type metal ion transport system permease component
E8E07_RS06815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8E07_RS06825	COG0151	Belongs to the GarS family
E8E07_RS06835	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E8E07_RS06865	COG2308	Evidence 4 Homologs of previously reported genes of
E8E07_RS06875	COG1305	Transglutaminase-like
E8E07_RS06885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E8E07_RS06890	COG0305	Participates in initiation and elongation during chromosome replication
E8E07_RS06915	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E8E07_RS06925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E8E07_RS06955	COG0726	polysaccharide deacetylase
E8E07_RS06955	COG1649	PFAM Uncharacterised BCR, COG1649
E8E07_RS06960	COG1215	transferase activity, transferring glycosyl groups
E8E07_RS06965	COG3658	cytochrome
E8E07_RS06975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E8E07_RS06990	COG0583	DNA-binding transcription factor activity
E8E07_RS07005	COG2890	protein-(glutamine-N5) methyltransferase activity
E8E07_RS07010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E8E07_RS07015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8E07_RS07030	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS07035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E8E07_RS07050	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E8E07_RS07060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E8E07_RS07065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E8E07_RS07075	COG2205	protein histidine kinase activity
E8E07_RS07080	COG0745	RESPONSE REGULATOR receiver
E8E07_RS07085	COG0174	glutamine synthetase
E8E07_RS07100	COG0477	Major facilitator Superfamily
E8E07_RS07105	COG0729	surface antigen
E8E07_RS07140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E8E07_RS07145	COG2814	Major facilitator Superfamily
E8E07_RS07155	COG0583	DNA-binding transcription factor activity
E8E07_RS07185	COG0564	pseudouridine synthase activity
E8E07_RS07190	COG0802	atpase or kinase
E8E07_RS07195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E8E07_RS07205	COG1923	regulation of RNA biosynthetic process
E8E07_RS07210	COG0697	spore germination
E8E07_RS07235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8E07_RS07240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E8E07_RS07240	COG0519	Catalyzes the synthesis of GMP from XMP
E8E07_RS07245	COG4302	ethanolamine ammonia-lyase activity
E8E07_RS07250	COG4303	Ethanolamine ammonia lyase large subunit
E8E07_RS07255	COG0531	amino acid
E8E07_RS07275	COG1454	alcohol dehydrogenase
E8E07_RS07280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8E07_RS07305	COG0308	aminopeptidase N
E8E07_RS07345	COG1605	Chorismate mutase
E8E07_RS07360	COG4772	TonB-dependent receptor
E8E07_RS07400	COG3772	lysozyme
E8E07_RS07425	COG0583	DNA-binding transcription factor activity
E8E07_RS07460	COG0488	(ABC) transporter
E8E07_RS07470	COG0589	response to stress
E8E07_RS07490	COG3135	benzoate transporter
E8E07_RS07495	COG1522	sequence-specific DNA binding
E8E07_RS07505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E8E07_RS07510	COG0583	DNA-binding transcription factor activity
E8E07_RS07520	COG0183	Belongs to the thiolase family
E8E07_RS07530	COG2030	dehydratase
E8E07_RS07535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E8E07_RS07560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E8E07_RS07570	COG0824	Thioesterase
E8E07_RS07575	COG1454	alcohol dehydrogenase
E8E07_RS07590	COG1335	isochorismatase
E8E07_RS07610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E8E07_RS07640	COG0069	glutamate synthase activity
E8E07_RS07665	COG2814	Major facilitator Superfamily
E8E07_RS07680	COG0511	ligase activity, forming carbon-carbon bonds
E8E07_RS07705	COG4264	IucA IucC family
E8E07_RS07715	COG4264	IucA IucC family
E8E07_RS07720	COG2423	ornithine cyclodeaminase activity
E8E07_RS07725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E8E07_RS07730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8E07_RS07730	COG1116	anion transmembrane transporter activity
E8E07_RS07745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8E07_RS07745	COG2146	nitrite reductase [NAD(P)H] activity
E8E07_RS07750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8E07_RS07755	COG0243	molybdopterin cofactor binding
E8E07_RS07765	COG0243	molybdopterin cofactor binding
E8E07_RS07775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8E07_RS07790	COG0315	cyclic pyranopterin monophosphate synthase activity
E8E07_RS07790	COG0521	Mo-molybdopterin cofactor biosynthetic process
E8E07_RS07795	COG0303	'Molybdopterin
E8E07_RS07805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8E07_RS07810	COG0697	spore germination
E8E07_RS07835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8E07_RS07855	COG0596	Alpha beta hydrolase
E8E07_RS07905	COG2204	response regulator
E8E07_RS07910	COG3852	Histidine kinase
E8E07_RS07935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E8E07_RS07940	COG0575	Belongs to the CDS family
E8E07_RS07955	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8E07_RS07975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8E07_RS07990	COG2137	regulation of response to DNA damage stimulus
E8E07_RS08000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E8E07_RS08005	COG1011	Hydrolase
E8E07_RS08020	COG1522	sequence-specific DNA binding
E8E07_RS08030	COG1113	amino acid transport
E8E07_RS08055	COG3293	Transposase
E8E07_RS08105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E8E07_RS08105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8E07_RS08105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8E07_RS08110	COG1105	Belongs to the carbohydrate kinase PfkB family
E8E07_RS08115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8E07_RS08115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E8E07_RS08145	COG0024	Methionine aminopeptidase
E8E07_RS08150	COG0583	DNA-binding transcription factor activity
E8E07_RS08160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E8E07_RS08165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E8E07_RS08170	COG0517	IMP dehydrogenase activity
E8E07_RS08170	COG0516	GMP reductase activity
E8E07_RS08195	COG0552	protein localization to endoplasmic reticulum
E8E07_RS08215	COG4890	Cyd operon protein YbgT
E8E07_RS08220	COG1294	oxidase, subunit
E8E07_RS08235	COG1585	Membrane protein implicated in regulation of membrane protease activity
E8E07_RS08245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E8E07_RS08260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8E07_RS08265	COG0569	domain protein
E8E07_RS08270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E8E07_RS08300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E8E07_RS08305	COG0542	response to heat
E8E07_RS08330	COG1902	pentaerythritol trinitrate reductase activity
E8E07_RS08330	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8E07_RS08370	COG0148	phosphopyruvate hydratase activity
E8E07_RS08375	COG2323	membrane
E8E07_RS08390	COG3293	Transposase
E8E07_RS08400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E8E07_RS08410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E8E07_RS08415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E8E07_RS08420	COG0183	Belongs to the thiolase family
E8E07_RS08425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E8E07_RS08430	COG0596	Alpha beta hydrolase
E8E07_RS08435	COG2271	Major facilitator Superfamily
E8E07_RS08440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E8E07_RS08445	COG3485	protocatechuate 3,4-dioxygenase
E8E07_RS08450	COG3485	protocatechuate 3,4-dioxygenase
E8E07_RS08455	COG0710	3-dehydroquinate dehydratase activity
E8E07_RS08460	COG3420	alginic acid biosynthetic process
E8E07_RS08465	COG3659	wide pore channel activity
E8E07_RS08470	COG4993	Dehydrogenase
E8E07_RS08480	COG2391	methyltransferase activity
E8E07_RS08495	COG1414	Transcriptional regulator
E8E07_RS08500	COG0583	DNA-binding transcription factor activity
E8E07_RS08505	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS08550	COG0154	amidase activity
E8E07_RS08570	COG4638	Rieske (2fe-2S)
E8E07_RS08580	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS08590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E8E07_RS08600	COG3733	amine oxidase
E8E07_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS08620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E8E07_RS08625	COG0183	Belongs to the thiolase family
E8E07_RS08630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E8E07_RS08635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E8E07_RS08645	COG4829	muconolactone delta-isomerase
E8E07_RS08650	COG4948	Mandelate Racemase Muconate Lactonizing
E8E07_RS08655	COG0583	DNA-binding transcription factor activity
E8E07_RS08665	COG2186	Transcriptional regulator
E8E07_RS08685	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS08695	COG2351	hydroxyisourate hydrolase activity
E8E07_RS08700	COG2233	PERMEase
E8E07_RS08710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8E07_RS08715	COG2186	Transcriptional regulator
E8E07_RS08730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8E07_RS08740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E8E07_RS08760	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8E07_RS08760	COG1902	pentaerythritol trinitrate reductase activity
E8E07_RS08770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E8E07_RS08790	COG1309	transcriptional regulator
E8E07_RS08795	COG0583	DNA-binding transcription factor activity
E8E07_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS08820	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS08830	COG0318	PFAM AMP-dependent synthetase and ligase
E8E07_RS08845	COG1309	transcriptional regulator
E8E07_RS08930	COG0583	DNA-binding transcription factor activity
E8E07_RS08955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8E07_RS08960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E8E07_RS09005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8E07_RS09020	COG2271	Major facilitator Superfamily
E8E07_RS09065	COG2207	Transcriptional regulator
E8E07_RS09070	COG1064	alcohol dehydrogenase
E8E07_RS09075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8E07_RS09095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E8E07_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS09105	COG3118	belongs to the thioredoxin family
E8E07_RS09110	COG1902	pentaerythritol trinitrate reductase activity
E8E07_RS09140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8E07_RS09145	COG1120	ATPase activity
E8E07_RS09165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E8E07_RS09215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E8E07_RS09260	COG3539	Fimbrial protein
E8E07_RS09285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E8E07_RS09325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E8E07_RS09335	COG2205	protein histidine kinase activity
E8E07_RS09340	COG0745	RESPONSE REGULATOR receiver
E8E07_RS09345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8E07_RS09350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8E07_RS09410	COG1535	isochorismatase
E8E07_RS09410	COG3433	isochorismatase activity
E8E07_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS09420	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E8E07_RS09425	COG4149	molybdate abc transporter
E8E07_RS09430	COG0725	ABC transporter, periplasmic molybdate-binding protein
E8E07_RS09440	COG4638	Rieske (2fe-2S)
E8E07_RS09445	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E8E07_RS09450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8E07_RS09450	COG0543	2 iron, 2 sulfur cluster binding
E8E07_RS09465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E8E07_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS09495	COG2207	Transcriptional regulator
E8E07_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS09505	COG2610	gluconate transmembrane transporter activity
E8E07_RS09545	COG0583	DNA-binding transcription factor activity
E8E07_RS09560	COG2031	fatty acid transporter
E8E07_RS09565	COG0183	Belongs to the thiolase family
E8E07_RS09570	COG0583	DNA-binding transcription factor activity
E8E07_RS09575	COG0583	DNA-binding transcription factor activity
E8E07_RS09590	COG1027	Aspartate ammonia-lyase
E8E07_RS09600	COG3293	Transposase
E8E07_RS09610	COG0477	Major facilitator Superfamily
E8E07_RS09620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E8E07_RS09625	COG1733	regulation of RNA biosynthetic process
E8E07_RS09630	COG2207	Transcriptional regulator
E8E07_RS09630	COG3708	Transcriptional regulator
E8E07_RS09645	COG0730	response to heat
E8E07_RS09650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8E07_RS09650	COG3453	Protein conserved in bacteria
E8E07_RS09665	COG3781	membrane
E8E07_RS09670	COG1063	alcohol dehydrogenase
E8E07_RS09680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8E07_RS09685	COG0508	dehydrogenase complex catalyzes the overall conversion of
E8E07_RS09690	COG0022	dehydrogenase e1 component
E8E07_RS09695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E8E07_RS09700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E8E07_RS09715	COG3706	GGDEF domain
E8E07_RS09735	COG0133	tryptophan synthase activity
E8E07_RS09745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8E07_RS09780	COG0583	DNA-binding transcription factor activity
E8E07_RS09785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E8E07_RS09795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E8E07_RS09855	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8E07_RS09860	COG4773	Receptor
E8E07_RS09885	COG0730	response to heat
E8E07_RS09890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E8E07_RS09905	COG0406	alpha-ribazole phosphatase activity
E8E07_RS09910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E8E07_RS09940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E8E07_RS09955	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS09960	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS09965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8E07_RS09970	COG2207	Transcriptional regulator
E8E07_RS09975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8E07_RS09980	COG0776	regulation of translation
E8E07_RS10005	COG0822	iron-sulfur transferase activity
E8E07_RS10010	COG0316	Belongs to the HesB IscA family
E8E07_RS10040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E8E07_RS10060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E8E07_RS10065	COG0702	epimerase
E8E07_RS10115	COG0601	transmembrane transport
E8E07_RS10120	COG0339	signal peptide processing
E8E07_RS10125	COG4166	transmembrane transport
E8E07_RS10140	COG3293	Transposase
E8E07_RS10145	COG4206	TonB-dependent receptor
E8E07_RS10175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E8E07_RS10180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E8E07_RS10195	COG2431	L-lysine efflux transmembrane transporter activity
E8E07_RS10210	COG0776	regulation of translation
E8E07_RS10275	COG0084	hydrolase, TatD family'
E8E07_RS10295	COG1663	tetraacyldisaccharide 4'-kinase activity
E8E07_RS10300	COG1132	(ABC) transporter
E8E07_RS10310	COG0811	peptide transport
E8E07_RS10315	COG1475	DNA binding
E8E07_RS10320	COG1192	Involved in chromosome partitioning
E8E07_RS10330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E8E07_RS10335	COG3178	'Phosphotransferase
E8E07_RS10345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8E07_RS10370	COG0424	maF-like protein
E8E07_RS10375	COG2850	peptidyl-arginine hydroxylation
E8E07_RS10385	COG0640	Transcriptional regulator
E8E07_RS10395	COG3619	membrane
E8E07_RS10400	COG3122	Protein conserved in bacteria
E8E07_RS10405	COG1132	(ABC) transporter
E8E07_RS10425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E8E07_RS10430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8E07_RS10440	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E8E07_RS10440	COG0506	proline dehydrogenase activity
E8E07_RS10440	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E8E07_RS10445	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E8E07_RS10460	COG3698	Phosphodiester glycosidase
E8E07_RS10470	COG2353	YceI-like domain
E8E07_RS10480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8E07_RS10525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E8E07_RS10525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E8E07_RS10550	COG3539	Fimbrial protein
E8E07_RS10575	COG0583	DNA-binding transcription factor activity
E8E07_RS10580	COG0697	spore germination
E8E07_RS10590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E8E07_RS10600	COG0583	DNA-binding transcription factor activity
E8E07_RS10630	COG1522	sequence-specific DNA binding
E8E07_RS10640	COG1126	abc transporter atp-binding protein
E8E07_RS10645	COG0765	amino acid transport
E8E07_RS10650	COG0765	amino acid transport
E8E07_RS10680	COG1464	Belongs to the NlpA lipoprotein family
E8E07_RS10690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8E07_RS10695	COG2011	ABC-type metal ion transport system permease component
E8E07_RS10700	COG0012	GTP binding
E8E07_RS10725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E8E07_RS10760	COG1917	Cupin 2, conserved barrel domain protein
E8E07_RS10760	COG2207	Transcriptional regulator
E8E07_RS10765	COG0386	Belongs to the glutathione peroxidase family
E8E07_RS10775	COG0436	Aminotransferase
E8E07_RS10780	COG1301	dicarboxylic acid transport
E8E07_RS10815	COG3634	alkyl hydroperoxide reductase activity
E8E07_RS10830	COG0583	DNA-binding transcription factor activity
E8E07_RS10835	COG0431	NADPH-dependent FMN reductase
E8E07_RS10840	COG0798	PFAM Bile acid sodium symporter
E8E07_RS10850	COG0640	Transcriptional regulator
E8E07_RS10865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E8E07_RS10875	COG0583	DNA-binding transcription factor activity
E8E07_RS10885	COG1953	Uracil, thiamine, allantoin
E8E07_RS10895	COG2175	clavaminate synthase activity
E8E07_RS10900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E8E07_RS10905	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E8E07_RS10910	COG4521	taurine ABC transporter
E8E07_RS10920	COG0477	Major facilitator Superfamily
E8E07_RS10945	COG1271	oxidase subunit
E8E07_RS10950	COG1294	oxidase, subunit
E8E07_RS10960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8E07_RS10980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E8E07_RS11000	COG3052	prosthetic group binding
E8E07_RS11005	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E8E07_RS11030	COG1346	cytolysis
E8E07_RS11040	COG0583	DNA-binding transcription factor activity
E8E07_RS11045	COG0625	glutathione transferase activity
E8E07_RS11050	COG0625	glutathione transferase activity
E8E07_RS11055	COG0583	DNA-binding transcription factor activity
E8E07_RS11070	COG1045	serine acetyltransferase
E8E07_RS11075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E8E07_RS11080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E8E07_RS11085	COG1280	lysine exporter protein (LysE YggA)
E8E07_RS11100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8E07_RS11105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8E07_RS11115	COG0765	amino acid transport
E8E07_RS11120	COG0765	amino acid transport
E8E07_RS11140	COG2205	protein histidine kinase activity
E8E07_RS11140	COG0784	Response regulator, receiver
E8E07_RS11160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E8E07_RS11180	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS11225	COG0583	DNA-binding transcription factor activity
E8E07_RS11240	COG2814	Major facilitator Superfamily
E8E07_RS11255	COG0318	PFAM AMP-dependent synthetase and ligase
E8E07_RS11260	COG1309	transcriptional regulator
E8E07_RS11265	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS11270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E8E07_RS11275	COG1024	Enoyl-CoA hydratase
E8E07_RS11280	COG4770	biotin carboxylase activity
E8E07_RS11290	COG0583	DNA-binding transcription factor activity
E8E07_RS11305	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS11315	COG2814	Major facilitator Superfamily
E8E07_RS11325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E8E07_RS11330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E8E07_RS11335	COG2814	Major facilitator Superfamily
E8E07_RS11340	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS11345	COG1024	Enoyl-CoA hydratase
E8E07_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS11355	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8E07_RS11360	COG0183	Belongs to the thiolase family
E8E07_RS11370	COG2814	Major facilitator Superfamily
E8E07_RS11380	COG1024	Enoyl-CoA hydratase
E8E07_RS11390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E8E07_RS11395	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS11400	COG2814	Major facilitator Superfamily
E8E07_RS11405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8E07_RS11410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E8E07_RS11425	COG3842	ATPase activity
E8E07_RS11430	COG1840	ABC-type Fe3 transport system, periplasmic component
E8E07_RS11445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8E07_RS11450	COG1414	Transcriptional regulator
E8E07_RS11480	COG2050	protein possibly involved in aromatic compounds catabolism
E8E07_RS11490	COG3327	negative regulation of DNA-templated transcription, initiation
E8E07_RS11495	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E8E07_RS11500	COG0183	Belongs to the thiolase family
E8E07_RS11505	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8E07_RS11510	COG1024	Enoyl-CoA hydratase
E8E07_RS11515	COG1024	Enoyl-CoA hydratase
E8E07_RS11520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8E07_RS11525	COG2151	metal-sulfur cluster biosynthetic enzyme
E8E07_RS11530	COG3396	Phenylacetate-CoA oxygenase
E8E07_RS11535	COG3460	Phenylacetate-CoA oxygenase
E8E07_RS11540	COG3396	Phenylacetate-CoA oxygenase
E8E07_RS11545	COG3293	Transposase
E8E07_RS11550	COG2030	dehydratase
E8E07_RS11550	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS11555	COG1760	l-serine dehydratase
E8E07_RS11575	COG0789	Transcriptional regulator
E8E07_RS11585	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E8E07_RS11590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8E07_RS11605	COG2807	transmembrane transport
E8E07_RS11610	COG0590	tRNA wobble adenosine to inosine editing
E8E07_RS11615	COG0666	response to abiotic stimulus
E8E07_RS11655	COG3293	Transposase
E8E07_RS11740	COG1116	anion transmembrane transporter activity
E8E07_RS11745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8E07_RS11755	COG0864	Transcriptional regulator
E8E07_RS11765	COG1733	regulation of RNA biosynthetic process
E8E07_RS11770	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8E07_RS11775	COG0439	Biotin carboxylase
E8E07_RS11790	COG1063	alcohol dehydrogenase
E8E07_RS11795	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8E07_RS11835	COG3293	Transposase
E8E07_RS11845	COG2831	hemolysin activation secretion protein
E8E07_RS11850	COG0038	chloride channel
E8E07_RS11855	COG4770	biotin carboxylase activity
E8E07_RS11875	COG1914	H( )-stimulated, divalent metal cation uptake system
E8E07_RS11880	COG0583	DNA-binding transcription factor activity
E8E07_RS11890	COG1595	DNA-templated transcription, initiation
E8E07_RS11900	COG3220	belongs to the UPF0276 family
E8E07_RS12025	COG3038	cytochrome b561
E8E07_RS12030	COG0753	catalase activity
E8E07_RS12050	COG2207	Transcriptional regulator
E8E07_RS12070	COG1278	Cold shock
E8E07_RS12105	COG1522	sequence-specific DNA binding
E8E07_RS12110	COG0531	amino acid
E8E07_RS12115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E8E07_RS12130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8E07_RS12145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E8E07_RS12155	COG4122	O-methyltransferase activity
E8E07_RS12185	COG1538	Outer membrane efflux protein
E8E07_RS12190	COG1137	ATPase activity
E8E07_RS12195	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E8E07_RS12205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E8E07_RS12255	COG2814	Major facilitator Superfamily
E8E07_RS12265	COG0668	transmembrane transport
E8E07_RS12310	COG1309	transcriptional regulator
E8E07_RS12325	COG2226	methyltransferase
E8E07_RS12330	COG1011	Hydrolase
E8E07_RS12355	COG1278	Cold shock
E8E07_RS12360	COG1560	Kdo2-lipid A biosynthetic process
E8E07_RS12365	COG1280	lysine exporter protein (LysE YggA)
E8E07_RS12400	COG1570	exodeoxyribonuclease VII activity
E8E07_RS12485	COG2871	sodium ion transport
E8E07_RS12495	COG0583	DNA-binding transcription factor activity
E8E07_RS12505	COG4638	Rieske (2fe-2S)
E8E07_RS12510	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E8E07_RS12515	COG0543	2 iron, 2 sulfur cluster binding
E8E07_RS12515	COG0633	Ferredoxin
E8E07_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS12530	COG3135	benzoate transporter
E8E07_RS12535	COG2814	Major facilitator Superfamily
E8E07_RS12550	COG1643	Atp-dependent helicase
E8E07_RS12575	COG3634	alkyl hydroperoxide reductase activity
E8E07_RS12595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E8E07_RS12605	COG0625	glutathione transferase activity
E8E07_RS12615	COG2885	chlorophyll binding
E8E07_RS12650	COG0542	response to heat
E8E07_RS12665	COG1765	OsmC-like protein
E8E07_RS12680	COG0667	Aldo Keto reductase
E8E07_RS12695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E8E07_RS12705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E8E07_RS12715	COG0527	aspartate kinase activity
E8E07_RS12725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E8E07_RS12735	COG3038	cytochrome b561
E8E07_RS12740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E8E07_RS12745	COG2252	PERMEase
E8E07_RS12755	COG1741	Belongs to the pirin family
E8E07_RS12760	COG1309	transcriptional regulator
E8E07_RS12775	COG2072	flavoprotein involved in K transport
E8E07_RS12780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E8E07_RS12785	COG0583	DNA-binding transcription factor activity
E8E07_RS12800	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E8E07_RS12830	COG1944	ATP diphosphatase activity
E8E07_RS12850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E8E07_RS12865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8E07_RS12880	COG2814	Major facilitator Superfamily
E8E07_RS12885	COG1024	Enoyl-CoA hydratase
E8E07_RS12890	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS12900	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS12925	COG0697	spore germination
E8E07_RS12945	COG1113	amino acid transport
E8E07_RS12985	COG0531	amino acid
E8E07_RS12995	COG1113	amino acid transport
E8E07_RS13030	COG4269	membrane
E8E07_RS13050	COG1902	pentaerythritol trinitrate reductase activity
E8E07_RS13050	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8E07_RS13065	COG3706	GGDEF domain
E8E07_RS13065	COG4251	negative regulation of phosphorylation
E8E07_RS13065	COG5001	Diguanylate cyclase
E8E07_RS13065	COG2203	Gaf domain
E8E07_RS13075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E8E07_RS13095	COG4172	Belongs to the ABC transporter superfamily
E8E07_RS13100	COG4239	(ABC) transporter, permease
E8E07_RS13105	COG4174	ABC transporter (Permease)
E8E07_RS13110	COG4166	transmembrane transport
E8E07_RS13115	COG1388	LysM domain
E8E07_RS13115	COG0741	lytic transglycosylase activity
E8E07_RS13115	COG1388	LysM domain
E8E07_RS13115	COG0741	lytic transglycosylase activity
E8E07_RS13160	COG0583	DNA-binding transcription factor activity
E8E07_RS13165	COG1279	arginine transmembrane transporter activity
E8E07_RS13175	COG0789	Transcriptional regulator
E8E07_RS13185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8E07_RS13190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8E07_RS13195	COG0006	proline dipeptidase activity
E8E07_RS13235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E8E07_RS13250	COG3384	dioxygenase
E8E07_RS13260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E8E07_RS13265	COG2878	Part of a membrane complex involved in electron transport
E8E07_RS13270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E8E07_RS13295	COG0768	penicillin binding
E8E07_RS13300	COG0742	ribosomal rna small subunit methyltransferase
E8E07_RS13315	COG0830	nickel cation binding
E8E07_RS13325	COG0804	urea catabolic process
E8E07_RS13350	COG3015	lipoprotein NlpE involved in copper resistance
E8E07_RS13365	COG1253	flavin adenine dinucleotide binding
E8E07_RS13370	COG2851	Citrate transporter
E8E07_RS13420	COG3293	Transposase
E8E07_RS13430	COG1773	rubredoxin
E8E07_RS13435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8E07_RS13440	COG2267	carboxylic ester hydrolase activity
E8E07_RS13445	COG0583	DNA-binding transcription factor activity
E8E07_RS13475	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E8E07_RS13480	COG4181	ATPase activity
E8E07_RS13505	COG4771	TonB-dependent receptor
E8E07_RS13525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E8E07_RS13545	COG0306	phosphate transporter
E8E07_RS13555	COG3958	Transketolase
E8E07_RS13560	COG3959	Transketolase, thiamine diphosphate binding domain
E8E07_RS13565	COG2271	Major facilitator Superfamily
E8E07_RS13570	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS13605	COG2223	nitrite transmembrane transporter activity
E8E07_RS13610	COG2207	Transcriptional regulator
E8E07_RS13615	COG2066	Belongs to the glutaminase family
E8E07_RS13620	COG0242	peptide deformylase activity
E8E07_RS13625	COG0477	Major facilitator Superfamily
E8E07_RS13635	COG0028	Belongs to the TPP enzyme family
E8E07_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS13655	COG2267	carboxylic ester hydrolase activity
E8E07_RS13665	COG2271	Major facilitator Superfamily
E8E07_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS13700	COG1414	Transcriptional regulator
E8E07_RS13725	COG1215	transferase activity, transferring glycosyl groups
E8E07_RS13730	COG0726	polysaccharide deacetylase
E8E07_RS13730	COG1649	PFAM Uncharacterised BCR, COG1649
E8E07_RS13740	COG4681	YaeQ
E8E07_RS13750	COG0523	cobalamin synthesis protein
E8E07_RS13780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8E07_RS13785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8E07_RS13790	COG1309	transcriptional regulator
E8E07_RS13815	COG2040	homocysteine
E8E07_RS13820	COG0531	amino acid
E8E07_RS13875	COG1595	DNA-templated transcription, initiation
E8E07_RS13885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8E07_RS13890	COG0477	Major facilitator Superfamily
E8E07_RS13940	COG0405	Gamma-glutamyltransferase
E8E07_RS13945	COG2814	Major facilitator Superfamily
E8E07_RS13955	COG2050	protein possibly involved in aromatic compounds catabolism
E8E07_RS13970	COG1090	epimerase
E8E07_RS13990	COG0420	3'-5' exonuclease activity
E8E07_RS14015	COG0735	belongs to the Fur family
E8E07_RS14020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8E07_RS14025	COG2914	Belongs to the UPF0125 (RnfH) family
E8E07_RS14045	COG0121	glutamine amidotransferase
E8E07_RS14060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E8E07_RS14070	COG0210	DNA helicase
E8E07_RS14075	COG2885	chlorophyll binding
E8E07_RS14080	COG0204	Acyl-transferase
E8E07_RS14095	COG2894	cell division
E8E07_RS14110	COG1280	lysine exporter protein (LysE YggA)
E8E07_RS14115	COG3293	Transposase
E8E07_RS14120	COG1674	ftsk spoiiie
E8E07_RS14125	COG0492	ferredoxin-NADP+ reductase activity
E8E07_RS14130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E8E07_RS14140	COG0456	acetyltransferase
E8E07_RS14155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8E07_RS14160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E8E07_RS14170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E8E07_RS14185	COG1981	membrane
E8E07_RS14195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E8E07_RS14195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8E07_RS14215	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS14220	COG4638	Rieske (2fe-2S)
E8E07_RS14225	COG0657	acetylesterase activity
E8E07_RS14235	COG0473	3-isopropylmalate dehydrogenase activity
E8E07_RS14240	COG0583	DNA-binding transcription factor activity
E8E07_RS14260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8E07_RS14295	COG0358	DNA primase activity
E8E07_RS14310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E8E07_RS14340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E8E07_RS14370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8E07_RS14380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E8E07_RS14380	COG0352	thiamine-phosphate diphosphorylase activity
E8E07_RS14380	COG0351	phosphomethylpyrimidine kinase
E8E07_RS14385	COG1652	LysM domain
E8E07_RS14410	COG1399	metal-binding, possibly nucleic acid-binding protein
E8E07_RS14415	COG3101	peptidyl-lysine hydroxylation
E8E07_RS14420	COG0009	L-threonylcarbamoyladenylate synthase
E8E07_RS14425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E8E07_RS14430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E8E07_RS14445	COG4106	trans-aconitate 2-methyltransferase activity
E8E07_RS14460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E8E07_RS14460	COG0596	Alpha beta hydrolase
E8E07_RS14460	COG2226	methyltransferase
E8E07_RS14470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E8E07_RS14475	COG2223	nitrite transmembrane transporter activity
E8E07_RS14495	COG1196	nuclear chromosome segregation
E8E07_RS14505	COG0730	response to heat
E8E07_RS14520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E8E07_RS14530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E8E07_RS14585	COG0489	protein tyrosine kinase activity
E8E07_RS14595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8E07_RS14595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8E07_RS14630	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E8E07_RS14635	COG2081	HI0933 family
E8E07_RS14645	COG0668	transmembrane transport
E8E07_RS14665	COG0583	DNA-binding transcription factor activity
E8E07_RS14685	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8E07_RS14690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8E07_RS14720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E8E07_RS14745	COG2199	diguanylate cyclase activity
E8E07_RS14760	COG0745	RESPONSE REGULATOR receiver
E8E07_RS14765	COG3293	Transposase
E8E07_RS14780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8E07_RS14830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E8E07_RS14845	COG0583	DNA-binding transcription factor activity
E8E07_RS14900	COG0583	DNA-binding transcription factor activity
E8E07_RS14915	COG0583	DNA-binding transcription factor activity
E8E07_RS14920	COG1053	succinate dehydrogenase
E8E07_RS14935	COG1309	transcriptional regulator
E8E07_RS14945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E8E07_RS14950	COG2814	Major facilitator Superfamily
E8E07_RS14955	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS14960	COG0583	DNA-binding transcription factor activity
E8E07_RS14965	COG1063	alcohol dehydrogenase
E8E07_RS14980	COG0582	viral genome integration into host DNA
E8E07_RS14985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E8E07_RS15045	COG3646	Phage regulatory protein
E8E07_RS15185	COG3409	Peptidoglycan-binding domain 1 protein
E8E07_RS15185	COG0860	N-Acetylmuramoyl-L-alanine amidase
E8E07_RS15230	COG4695	Portal protein
E8E07_RS15260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E8E07_RS15265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E8E07_RS15270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E8E07_RS15280	COG3293	Transposase
E8E07_RS15295	COG2132	Multicopper oxidase
E8E07_RS15305	COG0561	phosphatase activity
E8E07_RS15310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E8E07_RS15335	COG1214	PFAM Peptidase M22, glycoprotease
E8E07_RS15395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E8E07_RS15400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E8E07_RS15405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E8E07_RS15465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8E07_RS15475	COG1846	Transcriptional regulator
E8E07_RS15480	COG1764	response to oxidative stress
E8E07_RS15520	COG0037	tRNA processing
E8E07_RS15530	COG0248	Ppx GppA phosphatase
E8E07_RS15560	COG0072	phenylalanine-tRNA ligase activity
E8E07_RS15580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E8E07_RS15595	COG1238	metal cluster binding
E8E07_RS15600	COG0625	glutathione transferase activity
E8E07_RS15620	COG0318	PFAM AMP-dependent synthetase and ligase
E8E07_RS15625	COG3028	Belongs to the UPF0307 family
E8E07_RS15630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8E07_RS15650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E8E07_RS15655	COG0617	tRNA 3'-terminal CCA addition
E8E07_RS15660	COG1555	photosystem II stabilization
E8E07_RS15665	COG3956	TIGRFAM MazG family protein
E8E07_RS15670	COG4221	oxidoreductase activity
E8E07_RS15695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E8E07_RS15710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E8E07_RS15715	COG2205	protein histidine kinase activity
E8E07_RS15715	COG5002	protein histidine kinase activity
E8E07_RS15715	COG0784	Response regulator, receiver
E8E07_RS15720	COG1024	Enoyl-CoA hydratase
E8E07_RS15725	COG2084	Dehydrogenase
E8E07_RS15730	COG3622	Belongs to the hyi family
E8E07_RS15760	COG0697	spore germination
E8E07_RS15770	COG2814	Major facilitator Superfamily
E8E07_RS15815	COG0583	DNA-binding transcription factor activity
E8E07_RS15825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E8E07_RS15835	COG0084	hydrolase, TatD family'
E8E07_RS15850	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E8E07_RS15870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E8E07_RS15875	COG0440	acetolactate synthase activity
E8E07_RS15880	COG0028	Belongs to the TPP enzyme family
E8E07_RS15900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8E07_RS15905	COG1136	(ABC) transporter
E8E07_RS15905	COG0577	efflux transmembrane transporter activity
E8E07_RS15925	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E8E07_RS15930	COG1162	GTPase activity
E8E07_RS15940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E8E07_RS15960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8E07_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS16020	COG0318	PFAM AMP-dependent synthetase and ligase
E8E07_RS16030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8E07_RS16055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8E07_RS16075	COG1426	Protein conserved in bacteria
E8E07_RS16110	COG0793	Belongs to the peptidase S41A family
E8E07_RS16125	COG2267	carboxylic ester hydrolase activity
E8E07_RS16135	COG1012	belongs to the aldehyde dehydrogenase family
E8E07_RS16140	COG3265	gluconokinase activity
E8E07_RS16150	COG0800	Aldolase
E8E07_RS16165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E8E07_RS16170	COG0857	belongs to the CobB CobQ family
E8E07_RS16170	COG0280	phosphate acetyltransferase
E8E07_RS16175	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E8E07_RS16175	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E8E07_RS16195	COG0740	serine-type endopeptidase activity
E8E07_RS16205	COG4774	siderophore transport
E8E07_RS16215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E8E07_RS16225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E8E07_RS16225	COG2813	Specifically methylates the guanine in position
E8E07_RS16325	COG0788	formyltetrahydrofolate deformylase activity
E8E07_RS16350	COG4651	solute:proton antiporter activity
E8E07_RS16350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E8E07_RS16370	COG0724	RNA recognition motif
E8E07_RS16375	COG0210	DNA helicase
E8E07_RS16400	COG1733	regulation of RNA biosynthetic process
E8E07_RS16410	COG2900	Belongs to the SlyX family
E8E07_RS16415	COG0488	(ABC) transporter
E8E07_RS16430	COG1560	Kdo2-lipid A biosynthetic process
E8E07_RS16440	COG1301	dicarboxylic acid transport
E8E07_RS16495	COG0473	3-isopropylmalate dehydrogenase activity
E8E07_RS16520	COG0583	DNA-binding transcription factor activity
E8E07_RS16535	COG3293	Transposase
E8E07_RS16565	COG0583	DNA-binding transcription factor activity
E8E07_RS16575	COG0625	glutathione transferase activity
E8E07_RS16580	COG2378	regulation of single-species biofilm formation
E8E07_RS16585	COG0546	phosphoglycolate phosphatase activity
E8E07_RS16600	COG1530	ribonuclease E activity
E8E07_RS16605	COG0318	PFAM AMP-dependent synthetase and ligase
E8E07_RS16620	COG0583	DNA-binding transcription factor activity
E8E07_RS16625	COG4221	oxidoreductase activity
E8E07_RS16630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8E07_RS16640	COG0534	Mate efflux family protein
E8E07_RS16655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E8E07_RS16680	COG0493	'glutamate synthase
E8E07_RS16680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8E07_RS16690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E8E07_RS16695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8E07_RS16710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E8E07_RS16720	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E8E07_RS16720	COG0644	oxidoreductase
E8E07_RS16735	COG4535	Mg2 and Co2 transporter CorC
E8E07_RS16745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8E07_RS16765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E8E07_RS16775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E8E07_RS16785	COG0484	heat shock protein binding
E8E07_RS16790	COG0789	Transcriptional regulator
E8E07_RS16795	COG0598	Magnesium transport protein CorA
E8E07_RS16800	COG1185	polyribonucleotide nucleotidyltransferase activity
E8E07_RS16810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E8E07_RS16815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8E07_RS16820	COG1074	ATP-dependent DNA helicase activity
E8E07_RS16825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E8E07_RS16845	COG2226	methyltransferase
E8E07_RS16855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E8E07_RS16865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E8E07_RS16880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8E07_RS16880	COG2111	Na H antiporter
E8E07_RS16885	COG1006	Multisubunit Na H antiporter MnhC subunit
E8E07_RS16890	COG0651	ATP synthesis coupled electron transport
E8E07_RS16895	COG1863	multisubunit Na H antiporter MnhE subunit
E8E07_RS16900	COG2212	antiporter activity
E8E07_RS16905	COG1320	monovalent cation:proton antiporter activity
E8E07_RS16910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E8E07_RS16920	COG0195	Participates in both transcription termination and antitermination
E8E07_RS16970	COG0237	dephospho-CoA kinase activity
E8E07_RS16980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E8E07_RS16995	COG0497	DNA recombination
E8E07_RS17005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E8E07_RS17040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E8E07_RS17040	COG2169	Transcriptional regulator
E8E07_RS17045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E8E07_RS17125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E8E07_RS17140	COG0326	Molecular chaperone. Has ATPase activity
E8E07_RS17155	COG2056	Na+-H+ antiporter family
E8E07_RS17225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8E07_RS17255	COG0546	phosphoglycolate phosphatase activity
E8E07_RS17260	COG1716	ATPase activity
E8E07_RS17305	COG0181	hydroxymethylbilane synthase activity
E8E07_RS17315	COG3275	phosphorelay sensor kinase activity
E8E07_RS17335	COG1538	Outer membrane efflux protein
E8E07_RS17345	COG0697	spore germination
E8E07_RS17370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E8E07_RS17375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E8E07_RS17380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8E07_RS17385	COG0772	Belongs to the SEDS family
E8E07_RS17410	COG4974	Belongs to the 'phage' integrase family
E8E07_RS17415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E8E07_RS17425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E8E07_RS17435	COG2197	response regulator
E8E07_RS17450	COG0793	Belongs to the peptidase S41A family
E8E07_RS17455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E8E07_RS17460	COG0795	lipopolysaccharide-transporting ATPase activity
E8E07_RS17500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8E07_RS17500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8E07_RS17510	COG0004	ammonium transporteR
E8E07_RS17515	COG0347	Belongs to the P(II) protein family
E8E07_RS17525	COG0606	chelatase, subunit chli
E8E07_RS17530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8E07_RS17535	COG0235	Class ii aldolase
E8E07_RS17540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8E07_RS17560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E8E07_RS17575	COG0318	PFAM AMP-dependent synthetase and ligase
E8E07_RS17585	COG0477	Major facilitator Superfamily
E8E07_RS17590	COG2860	membrane
E8E07_RS17600	COG1253	flavin adenine dinucleotide binding
E8E07_RS17610	COG2814	Major facilitator Superfamily
E8E07_RS17620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E8E07_RS17630	COG0745	RESPONSE REGULATOR receiver
E8E07_RS17635	COG2205	protein histidine kinase activity
E8E07_RS17640	COG4452	Inner membrane protein CreD
E8E07_RS17680	COG0655	NAD(P)H dehydrogenase (quinone) activity
E8E07_RS17695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E8E07_RS17725	COG1309	transcriptional regulator
E8E07_RS17760	COG0758	DNA mediated transformation
E8E07_RS17770	COG0697	spore germination
E8E07_RS17775	COG1309	transcriptional regulator
E8E07_RS17790	COG0386	Belongs to the glutathione peroxidase family
E8E07_RS17805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E8E07_RS17815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E8E07_RS17855	COG1121	(ABC) transporter
E8E07_RS17860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8E07_RS17865	COG1280	lysine exporter protein (LysE YggA)
E8E07_RS17870	COG2837	iron assimilation
E8E07_RS17875	COG0281	malic enzyme
E8E07_RS17920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8E07_RS17925	COG0519	Catalyzes the synthesis of GMP from XMP
E8E07_RS17925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E8E07_RS17930	COG4399	Belongs to the UPF0754 family
E8E07_RS17935	COG2259	Doxx family
E8E07_RS17940	COG0586	Pfam SNARE associated Golgi protein
E8E07_RS17955	COG1192	Involved in chromosome partitioning
E8E07_RS17965	COG0271	Belongs to the BolA IbaG family
E8E07_RS18005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E8E07_RS18005	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E8E07_RS18005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8E07_RS18005	COG3321	synthase
E8E07_RS18010	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS18015	COG0318	PFAM AMP-dependent synthetase and ligase
E8E07_RS18020	COG2197	response regulator
E8E07_RS18035	COG3916	Acyl-homoserine-lactone synthase
E8E07_RS18040	COG0477	Major facilitator Superfamily
E8E07_RS18045	COG1024	Enoyl-CoA hydratase
E8E07_RS18050	COG1024	Enoyl-CoA hydratase
E8E07_RS18055	COG1960	acyl-CoA dehydrogenase activity
E8E07_RS18060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8E07_RS18080	COG1113	amino acid transport
E8E07_RS18085	COG1113	amino acid transport
E8E07_RS18090	COG0251	oxidation-reduction process
E8E07_RS18130	COG0564	pseudouridine synthase activity
E8E07_RS18150	COG1309	transcriptional regulator
E8E07_RS18155	COG1309	transcriptional regulator
E8E07_RS18165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E8E07_RS18240	COG1051	belongs to the nudix hydrolase family
E8E07_RS18265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E8E07_RS18280	COG1802	Transcriptional regulator
E8E07_RS18290	COG1448	Aminotransferase
E8E07_RS18295	COG0277	FAD linked oxidase domain protein
E8E07_RS18305	COG2186	Transcriptional regulator
E8E07_RS18315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E8E07_RS18325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8E07_RS18340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E8E07_RS18345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E8E07_RS18385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E8E07_RS18395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E8E07_RS18400	COG1596	polysaccharide export
E8E07_RS18425	COG0728	peptidoglycan biosynthetic process
E8E07_RS18430	COG3023	N-Acetylmuramoyl-L-alanine amidase
E8E07_RS18485	COG0546	phosphoglycolate phosphatase activity
E8E07_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
E8E07_RS18505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E8E07_RS18505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E8E07_RS18510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8E07_RS18515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8E07_RS18520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E8E07_RS18525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E8E07_RS18530	COG1116	anion transmembrane transporter activity
E8E07_RS18535	COG1309	transcriptional regulator
E8E07_RS18540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E8E07_RS18550	COG0196	riboflavin kinase activity
E8E07_RS18555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E8E07_RS18565	COG1047	Peptidyl-prolyl cis-trans
E8E07_RS18605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E8E07_RS18610	COG0657	acetylesterase activity
E8E07_RS18660	COG2951	lytic endotransglycosylase activity
E8E07_RS18665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E8E07_RS18680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E8E07_RS18690	COG0671	phosphoesterase, PA-phosphatase related
E8E07_RS18695	COG0861	Integral membrane protein TerC family
E8E07_RS18705	COG0754	glutathionylspermidine amidase activity
E8E07_RS18715	COG0402	S-adenosylhomocysteine deaminase activity
E8E07_RS18730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E8E07_RS18735	COG1230	cation diffusion facilitator family transporter
E8E07_RS18750	COG0706	membrane insertase activity
E8E07_RS18870	COG4372	Transposase
E8E07_RS18910	COG3328	transposase activity
E8E07_RS18960	COG3328	transposase activity
E8E07_RS18965	COG3173	Aminoglycoside phosphotransferase
E8E07_RS18970	COG0488	(ABC) transporter
E8E07_RS19020	COG1660	Displays ATPase and GTPase activities
E8E07_RS19070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E8E07_RS19095	COG2369	cell adhesion
E8E07_RS19100	COG0582	viral genome integration into host DNA
E8E07_RS19125	COG0789	Transcriptional regulator
E8E07_RS19155	COG4680	protein conserved in bacteria
E8E07_RS19180	COG1192	Involved in chromosome partitioning
E8E07_RS19185	COG1475	DNA binding
E8E07_RS19195	COG4372	Transposase
E8E07_RS19245	COG4974	Belongs to the 'phage' integrase family
E8E07_RS19365	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
E8E07_RS19405	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E8E07_RS19445	COG4221	oxidoreductase activity
E8E07_RS19450	COG0583	DNA-binding transcription factor activity
E8E07_RS19455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E8E07_RS19460	COG3321	synthase
E8E07_RS19460	COG0604	alcohol dehydrogenase
E8E07_RS19475	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E8E07_RS19490	COG1979	alcohol dehydrogenase
E8E07_RS19500	COG1902	pentaerythritol trinitrate reductase activity
E8E07_RS19510	COG1309	transcriptional regulator
E8E07_RS19515	COG2130	NADP-dependent
E8E07_RS19530	COG0582	viral genome integration into host DNA
E8E07_RS19555	COG0789	Transcriptional regulator
E8E07_RS19585	COG1373	ATPase (AAA superfamily
E8E07_RS19620	COG3293	Transposase