locus-tag	class	description
FR838_RS00035	COG0765	amino acid transport
FR838_RS00040	COG0765	amino acid transport
FR838_RS00045	COG1126	abc transporter atp-binding protein
FR838_RS00055	COG1522	sequence-specific DNA binding
FR838_RS00070	COG1309	transcriptional regulator
FR838_RS00090	COG0583	DNA-binding transcription factor activity
FR838_RS00100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FR838_RS00110	COG0697	spore germination
FR838_RS00115	COG0583	DNA-binding transcription factor activity
FR838_RS00150	COG3539	Fimbrial protein
FR838_RS00155	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS00180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FR838_RS00180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FR838_RS00225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FR838_RS00235	COG2353	YceI-like domain
FR838_RS00245	COG3698	Phosphodiester glycosidase
FR838_RS00260	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FR838_RS00265	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FR838_RS00265	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FR838_RS00265	COG0506	proline dehydrogenase activity
FR838_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR838_RS00280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FR838_RS00300	COG1132	(ABC) transporter
FR838_RS00305	COG3122	Protein conserved in bacteria
FR838_RS00310	COG3619	membrane
FR838_RS00320	COG0640	Transcriptional regulator
FR838_RS00330	COG2850	peptidyl-arginine hydroxylation
FR838_RS00335	COG0424	maF-like protein
FR838_RS00360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR838_RS00370	COG3178	'Phosphotransferase
FR838_RS00375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FR838_RS00385	COG1192	Involved in chromosome partitioning
FR838_RS00390	COG1475	DNA binding
FR838_RS00395	COG0811	peptide transport
FR838_RS00405	COG1132	(ABC) transporter
FR838_RS00410	COG1663	tetraacyldisaccharide 4'-kinase activity
FR838_RS00430	COG0084	hydrolase, TatD family'
FR838_RS00495	COG0776	regulation of translation
FR838_RS00510	COG2431	L-lysine efflux transmembrane transporter activity
FR838_RS00525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FR838_RS00530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FR838_RS00575	COG4166	transmembrane transport
FR838_RS00580	COG0339	signal peptide processing
FR838_RS00585	COG0601	transmembrane transport
FR838_RS00625	COG0702	epimerase
FR838_RS00630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FR838_RS00650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FR838_RS00680	COG0316	Belongs to the HesB IscA family
FR838_RS00685	COG0822	iron-sulfur transferase activity
FR838_RS00710	COG0776	regulation of translation
FR838_RS00715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR838_RS00720	COG2207	Transcriptional regulator
FR838_RS00725	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR838_RS00730	COG1960	acyl-CoA dehydrogenase activity
FR838_RS00735	COG1960	acyl-CoA dehydrogenase activity
FR838_RS00750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FR838_RS00780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FR838_RS00800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR838_RS00805	COG0730	response to heat
FR838_RS00830	COG4773	Receptor
FR838_RS00835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR838_RS00895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FR838_RS00905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FR838_RS00910	COG0583	DNA-binding transcription factor activity
FR838_RS00940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FR838_RS00950	COG0133	tryptophan synthase activity
FR838_RS00970	COG3706	GGDEF domain
FR838_RS00995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FR838_RS01000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FR838_RS01005	COG0022	dehydrogenase e1 component
FR838_RS01010	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR838_RS01015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR838_RS01025	COG1063	alcohol dehydrogenase
FR838_RS01030	COG3781	membrane
FR838_RS01050	COG0730	response to heat
FR838_RS01075	COG0583	DNA-binding transcription factor activity
FR838_RS01080	COG0183	Belongs to the thiolase family
FR838_RS01085	COG2031	fatty acid transporter
FR838_RS01100	COG0583	DNA-binding transcription factor activity
FR838_RS01145	COG2610	gluconate transmembrane transporter activity
FR838_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS01155	COG2207	Transcriptional regulator
FR838_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS01185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR838_RS01200	COG0543	2 iron, 2 sulfur cluster binding
FR838_RS01200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR838_RS01205	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FR838_RS01210	COG4638	Rieske (2fe-2S)
FR838_RS01220	COG0725	ABC transporter, periplasmic molybdate-binding protein
FR838_RS01225	COG4149	molybdate abc transporter
FR838_RS01230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FR838_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS01240	COG1535	isochorismatase
FR838_RS01240	COG3433	isochorismatase activity
FR838_RS01295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR838_RS01300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR838_RS01305	COG0745	RESPONSE REGULATOR receiver
FR838_RS01310	COG2205	protein histidine kinase activity
FR838_RS01340	COG0753	catalase activity
FR838_RS01355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FR838_RS01380	COG3539	Fimbrial protein
FR838_RS01395	COG4628	conserved protein (DUF2132)
FR838_RS01405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FR838_RS01455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FR838_RS01505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FR838_RS01515	COG1120	ATPase activity
FR838_RS01520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR838_RS01595	COG0583	DNA-binding transcription factor activity
FR838_RS01665	COG1309	transcriptional regulator
FR838_RS01680	COG0318	PFAM AMP-dependent synthetase and ligase
FR838_RS01690	COG1960	acyl-CoA dehydrogenase activity
FR838_RS01700	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS01715	COG0583	DNA-binding transcription factor activity
FR838_RS01720	COG1309	transcriptional regulator
FR838_RS01760	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR838_RS01760	COG1902	pentaerythritol trinitrate reductase activity
FR838_RS01785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR838_RS01800	COG2186	Transcriptional regulator
FR838_RS01805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR838_RS01815	COG2233	PERMEase
FR838_RS01820	COG2351	hydroxyisourate hydrolase activity
FR838_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS01845	COG2186	Transcriptional regulator
FR838_RS01855	COG0583	DNA-binding transcription factor activity
FR838_RS01860	COG4948	Mandelate Racemase Muconate Lactonizing
FR838_RS01865	COG4829	muconolactone delta-isomerase
FR838_RS01875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FR838_RS01880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FR838_RS01885	COG0183	Belongs to the thiolase family
FR838_RS01890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR838_RS01895	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS01905	COG3733	amine oxidase
FR838_RS01915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR838_RS01925	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS01935	COG4638	Rieske (2fe-2S)
FR838_RS01955	COG0154	amidase activity
FR838_RS01965	COG2814	Major facilitator Superfamily
FR838_RS01990	COG1960	acyl-CoA dehydrogenase activity
FR838_RS01995	COG0583	DNA-binding transcription factor activity
FR838_RS02000	COG1414	Transcriptional regulator
FR838_RS02015	COG2391	methyltransferase activity
FR838_RS02025	COG4993	Dehydrogenase
FR838_RS02030	COG3659	wide pore channel activity
FR838_RS02035	COG3420	alginic acid biosynthetic process
FR838_RS02040	COG0710	3-dehydroquinate dehydratase activity
FR838_RS02045	COG3485	protocatechuate 3,4-dioxygenase
FR838_RS02050	COG3485	protocatechuate 3,4-dioxygenase
FR838_RS02055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FR838_RS02060	COG2271	Major facilitator Superfamily
FR838_RS02065	COG0596	Alpha beta hydrolase
FR838_RS02070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FR838_RS02075	COG0183	Belongs to the thiolase family
FR838_RS02080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FR838_RS02085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FR838_RS02095	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FR838_RS02100	COG4773	Receptor
FR838_RS02110	COG2323	membrane
FR838_RS02115	COG0148	phosphopyruvate hydratase activity
FR838_RS02155	COG1902	pentaerythritol trinitrate reductase activity
FR838_RS02155	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR838_RS02170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR838_RS02180	COG0542	response to heat
FR838_RS02185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FR838_RS02215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FR838_RS02220	COG0569	domain protein
FR838_RS02225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR838_RS02240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR838_RS02250	COG1585	Membrane protein implicated in regulation of membrane protease activity
FR838_RS02265	COG1294	oxidase, subunit
FR838_RS02270	COG4890	Cyd operon protein YbgT
FR838_RS02295	COG0552	protein localization to endoplasmic reticulum
FR838_RS02320	COG0517	IMP dehydrogenase activity
FR838_RS02320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FR838_RS02325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FR838_RS02330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FR838_RS02340	COG0583	DNA-binding transcription factor activity
FR838_RS02345	COG0024	Methionine aminopeptidase
FR838_RS02355	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FR838_RS02375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FR838_RS02375	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR838_RS02380	COG1105	Belongs to the carbohydrate kinase PfkB family
FR838_RS02385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR838_RS02385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR838_RS02385	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FR838_RS02440	COG1011	Hydrolase
FR838_RS02445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FR838_RS02455	COG2137	regulation of response to DNA damage stimulus
FR838_RS02470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR838_RS02505	COG0575	Belongs to the CDS family
FR838_RS02510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FR838_RS02535	COG3852	Histidine kinase
FR838_RS02540	COG2204	response regulator
FR838_RS02600	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS02615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FR838_RS02640	COG0697	spore germination
FR838_RS02645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR838_RS02655	COG0303	'Molybdopterin
FR838_RS02660	COG0315	cyclic pyranopterin monophosphate synthase activity
FR838_RS02660	COG0521	Mo-molybdopterin cofactor biosynthetic process
FR838_RS02675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FR838_RS02680	COG0243	molybdopterin cofactor binding
FR838_RS02690	COG0243	molybdopterin cofactor binding
FR838_RS02695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR838_RS02700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR838_RS02700	COG2146	nitrite reductase [NAD(P)H] activity
FR838_RS02715	COG1116	anion transmembrane transporter activity
FR838_RS02715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR838_RS02720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FR838_RS02725	COG2423	ornithine cyclodeaminase activity
FR838_RS02730	COG4264	IucA IucC family
FR838_RS02740	COG4264	IucA IucC family
FR838_RS02765	COG0511	ligase activity, forming carbon-carbon bonds
FR838_RS02780	COG2814	Major facilitator Superfamily
FR838_RS02810	COG0069	glutamate synthase activity
FR838_RS02840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FR838_RS02860	COG1335	isochorismatase
FR838_RS02865	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS02885	COG1454	alcohol dehydrogenase
FR838_RS02890	COG0824	Thioesterase
FR838_RS02900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FR838_RS02925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FR838_RS02930	COG2030	dehydratase
FR838_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS02940	COG0183	Belongs to the thiolase family
FR838_RS02950	COG0583	DNA-binding transcription factor activity
FR838_RS02955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FR838_RS02965	COG1522	sequence-specific DNA binding
FR838_RS02970	COG3135	benzoate transporter
FR838_RS02990	COG0589	response to stress
FR838_RS02995	COG0488	(ABC) transporter
FR838_RS03030	COG0583	DNA-binding transcription factor activity
FR838_RS03060	COG3328	transposase activity
FR838_RS03065	COG1733	regulation of RNA biosynthetic process
FR838_RS03075	COG3772	lysozyme
FR838_RS03140	COG4774	siderophore transport
FR838_RS03145	COG4772	TonB-dependent receptor
FR838_RS03180	COG1605	Chorismate mutase
FR838_RS03215	COG0308	aminopeptidase N
FR838_RS03240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR838_RS03245	COG1454	alcohol dehydrogenase
FR838_RS03265	COG0531	amino acid
FR838_RS03270	COG4303	Ethanolamine ammonia lyase large subunit
FR838_RS03275	COG4302	ethanolamine ammonia-lyase activity
FR838_RS03280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FR838_RS03280	COG0519	Catalyzes the synthesis of GMP from XMP
FR838_RS03285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR838_RS03310	COG0697	spore germination
FR838_RS03315	COG1923	regulation of RNA biosynthetic process
FR838_RS03325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FR838_RS03330	COG0802	atpase or kinase
FR838_RS03350	COG1187	pseudouridine synthase activity
FR838_RS03365	COG0583	DNA-binding transcription factor activity
FR838_RS03410	COG0729	surface antigen
FR838_RS03430	COG0174	glutamine synthetase
FR838_RS03435	COG0745	RESPONSE REGULATOR receiver
FR838_RS03440	COG2205	protein histidine kinase activity
FR838_RS03450	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FR838_RS03455	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FR838_RS03465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FR838_RS03480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR838_RS03485	COG1960	acyl-CoA dehydrogenase activity
FR838_RS03500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR838_RS03505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR838_RS03510	COG2890	protein-(glutamine-N5) methyltransferase activity
FR838_RS03525	COG0583	DNA-binding transcription factor activity
FR838_RS03540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FR838_RS03550	COG3658	cytochrome
FR838_RS03555	COG1215	transferase activity, transferring glycosyl groups
FR838_RS03560	COG1649	PFAM Uncharacterised BCR, COG1649
FR838_RS03560	COG0726	polysaccharide deacetylase
FR838_RS03590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FR838_RS03595	COG1845	cytochrome c oxidase, subunit III
FR838_RS03600	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FR838_RS03625	COG0305	Participates in initiation and elongation during chromosome replication
FR838_RS03630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FR838_RS03640	COG1305	Transglutaminase-like
FR838_RS03650	COG2308	Evidence 4 Homologs of previously reported genes of
FR838_RS03680	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FR838_RS03690	COG0151	Belongs to the GarS family
FR838_RS03700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FR838_RS03705	COG2011	ABC-type metal ion transport system permease component
FR838_RS03710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR838_RS03720	COG1301	dicarboxylic acid transport
FR838_RS03750	COG1794	racemase activity, acting on amino acids and derivatives
FR838_RS03765	COG0745	RESPONSE REGULATOR receiver
FR838_RS03770	COG0642	Histidine kinase
FR838_RS03775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FR838_RS03785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FR838_RS03835	COG2351	hydroxyisourate hydrolase activity
FR838_RS03845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FR838_RS03845	COG3008	intermembrane lipid transfer
FR838_RS03850	COG2995	paraquat-inducible protein a
FR838_RS03865	COG2985	domain, Protein
FR838_RS03875	COG1309	transcriptional regulator
FR838_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS03915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FR838_RS03915	COG0475	glutathione-regulated potassium exporter activity
FR838_RS03920	COG0786	glutamate:sodium symporter activity
FR838_RS03925	COG3243	poly(R)-hydroxyalkanoic acid synthase
FR838_RS03940	COG1278	Cold shock
FR838_RS03995	COG1610	YqeY-like protein
FR838_RS04000	COG4783	chaperone-mediated protein folding
FR838_RS04025	COG1286	toxin biosynthetic process
FR838_RS04055	COG0778	Nitroreductase
FR838_RS04065	COG0513	Belongs to the DEAD box helicase family
FR838_RS04085	COG2363	Small membrane protein
FR838_RS04115	COG4650	regulator
FR838_RS04120	COG1234	tRNA 3'-trailer cleavage
FR838_RS04125	COG1690	Belongs to the RtcB family
FR838_RS04145	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR838_RS04150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FR838_RS04160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FR838_RS04175	COG1960	acyl-CoA dehydrogenase activity
FR838_RS04180	COG1301	dicarboxylic acid transport
FR838_RS04190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FR838_RS04195	COG3139	Protein of unknown function (DUF1315)
FR838_RS04200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FR838_RS04205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FR838_RS04215	COG0494	nUDIX hydrolase
FR838_RS04225	COG0642	Histidine kinase
FR838_RS04240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR838_RS04250	COG1720	tRNA m6t6A37 methyltransferase activity
FR838_RS04260	COG0384	phenazine biosynthesis protein PhzF
FR838_RS04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR838_RS04270	COG0826	peptidase U32
FR838_RS04275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR838_RS04285	COG4598	ABC transporter
FR838_RS04290	COG4160	amino acid transport
FR838_RS04295	COG4215	(ABC) transporter
FR838_RS04300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR838_RS04310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR838_RS04355	COG1131	(ABC) transporter
FR838_RS04360	COG0842	Transport permease protein
FR838_RS04375	COG0772	Belongs to the SEDS family
FR838_RS04380	COG2951	lytic endotransglycosylase activity
FR838_RS04420	COG0052	Belongs to the universal ribosomal protein uS2 family
FR838_RS04425	COG0024	Methionine aminopeptidase
FR838_RS04435	COG2223	nitrite transmembrane transporter activity
FR838_RS04445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR838_RS04450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FR838_RS04455	COG1960	acyl-CoA dehydrogenase activity
FR838_RS04470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FR838_RS04475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FR838_RS04480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FR838_RS04500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FR838_RS04505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FR838_RS04510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FR838_RS04545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FR838_RS04555	COG0174	glutamine synthetase
FR838_RS04570	COG0512	Glutamine amidotransferase of anthranilate synthase
FR838_RS04605	COG2840	Smr protein MutS2
FR838_RS04615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FR838_RS04625	COG0302	gtp cyclohydrolase
FR838_RS04645	COG3739	integral membrane protein
FR838_RS04665	COG1169	isochorismate synthase
FR838_RS04670	COG2977	Belongs to the P-Pant transferase superfamily
FR838_RS04675	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FR838_RS04680	COG1132	(ABC) transporter
FR838_RS04685	COG1132	(ABC) transporter
FR838_RS04710	COG4774	siderophore transport
FR838_RS04715	COG4607	ABC-type enterochelin transport system periplasmic component
FR838_RS04720	COG4604	ABC transporter, ATP-binding protein
FR838_RS04725	COG4605	iron ion homeostasis
FR838_RS04730	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR838_RS04735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FR838_RS04750	COG1741	Belongs to the pirin family
FR838_RS04770	COG2801	Transposase and inactivated derivatives
FR838_RS04805	COG2879	small protein
FR838_RS04810	COG1966	Carbon starvation protein
FR838_RS04815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FR838_RS04855	COG1067	ATP-dependent peptidase activity
FR838_RS04860	COG0583	DNA-binding transcription factor activity
FR838_RS04885	COG1686	Belongs to the peptidase S11 family
FR838_RS04890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FR838_RS04925	COG3328	transposase activity
FR838_RS04935	COG0616	signal peptide processing
FR838_RS04940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FR838_RS04950	COG0573	inorganic phosphate transmembrane transporter activity
FR838_RS04955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FR838_RS04960	COG1113	amino acid transport
FR838_RS04965	COG3961	Belongs to the TPP enzyme family
FR838_RS04970	COG1522	sequence-specific DNA binding
FR838_RS04980	COG0076	glutamate decarboxylase activity
FR838_RS04985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR838_RS05000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR838_RS05035	COG0352	thiamine-phosphate diphosphorylase activity
FR838_RS05060	COG0612	Peptidase, M16
FR838_RS05070	COG1823	symporter activity
FR838_RS05075	COG0583	DNA-binding transcription factor activity
FR838_RS05080	COG0477	Major facilitator Superfamily
FR838_RS05095	COG1187	pseudouridine synthase activity
FR838_RS05110	COG1686	Belongs to the peptidase S11 family
FR838_RS05115	COG1252	NADH dehydrogenase
FR838_RS05125	COG0415	Belongs to the DNA photolyase family
FR838_RS05140	COG1215	transferase activity, transferring glycosyl groups
FR838_RS05155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FR838_RS05170	COG2070	2-Nitropropane dioxygenase
FR838_RS05215	COG2962	Rard protein
FR838_RS05225	COG0556	nucleotide-excision repair
FR838_RS05245	COG0436	Aminotransferase
FR838_RS05275	COG4221	oxidoreductase activity
FR838_RS05285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FR838_RS05300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FR838_RS05305	COG0571	ribonuclease III activity
FR838_RS05315	COG0681	Belongs to the peptidase S26 family
FR838_RS05320	COG0481	GTPase activity
FR838_RS05330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FR838_RS05350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FR838_RS05355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FR838_RS05360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FR838_RS05370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FR838_RS05375	COG4208	sulfate ABC transporter
FR838_RS05380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FR838_RS05385	COG0583	DNA-binding transcription factor activity
FR838_RS05390	COG4625	pathogenesis
FR838_RS05405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FR838_RS05420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FR838_RS05435	COG1056	cytidyltransferase-related domain
FR838_RS05435	COG1051	belongs to the nudix hydrolase family
FR838_RS05440	COG1024	Enoyl-CoA hydratase
FR838_RS05445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FR838_RS05450	COG2814	Major facilitator Superfamily
FR838_RS05455	COG0047	phosphoribosylformylglycinamidine synthase activity
FR838_RS05455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FR838_RS05475	COG1473	amidohydrolase
FR838_RS05480	COG0824	Thioesterase
FR838_RS05500	COG0823	Involved in the tonB-independent uptake of proteins
FR838_RS05520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR838_RS05560	COG0628	permease
FR838_RS05570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FR838_RS05575	COG0596	Alpha beta hydrolase
FR838_RS05580	COG0616	signal peptide processing
FR838_RS05580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FR838_RS05590	COG2333	competence protein COMEC
FR838_RS05590	COG0658	competence protein
FR838_RS05595	COG1136	(ABC) transporter
FR838_RS05600	COG4591	ABC-type transport system involved in lipoprotein release permease component
FR838_RS05630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR838_RS05660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FR838_RS05665	COG1280	lysine exporter protein (LysE YggA)
FR838_RS05675	COG0019	diaminopimelate decarboxylase activity
FR838_RS05685	COG1113	amino acid transport
FR838_RS05690	COG1115	amino acid carrier protein
FR838_RS05715	COG3339	Conserved Protein
FR838_RS05720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FR838_RS05725	COG0243	molybdopterin cofactor binding
FR838_RS05730	COG1929	Belongs to the glycerate kinase type-1 family
FR838_RS05745	COG0778	Nitroreductase
FR838_RS05750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR838_RS05755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR838_RS05780	COG2801	Transposase and inactivated derivatives
FR838_RS05810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR838_RS05835	COG0741	lytic transglycosylase activity
FR838_RS05855	COG0584	glycerophosphoryl diester phosphodiesterase
FR838_RS05860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR838_RS05870	COG0582	viral genome integration into host DNA
FR838_RS05875	COG1074	ATP-dependent DNA helicase activity
FR838_RS05905	COG2814	Major facilitator Superfamily
FR838_RS05980	COG2801	Transposase and inactivated derivatives
FR838_RS06025	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS06035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FR838_RS06040	COG1597	lipid kinase activity
FR838_RS06055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FR838_RS06060	COG0477	Major facilitator Superfamily
FR838_RS06070	COG2264	protein methyltransferase activity
FR838_RS06115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FR838_RS06120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FR838_RS06155	COG0505	Belongs to the CarA family
FR838_RS06170	COG1309	transcriptional regulator
FR838_RS06175	COG0251	oxidation-reduction process
FR838_RS06185	COG0589	response to stress
FR838_RS06205	COG2843	Capsule synthesis protein
FR838_RS06225	COG2321	neutral zinc metallopeptidase
FR838_RS06230	COG2354	Protein conserved in bacteria
FR838_RS06250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR838_RS06275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FR838_RS06280	COG1053	succinate dehydrogenase
FR838_RS06285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FR838_RS06290	COG2009	succinate dehydrogenase
FR838_RS06335	COG2921	Belongs to the UPF0250 family
FR838_RS06340	COG0321	lipoyl(octanoyl) transferase activity
FR838_RS06355	COG0531	amino acid
FR838_RS06390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FR838_RS06395	COG1648	precorrin-2 dehydrogenase activity
FR838_RS06395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FR838_RS06410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FR838_RS06435	COG0671	phosphoesterase, PA-phosphatase related
FR838_RS06440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR838_RS06450	COG1538	Outer membrane efflux protein
FR838_RS06455	COG0393	Putative heavy-metal-binding
FR838_RS06460	COG0393	Putative heavy-metal-binding
FR838_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS06480	COG0525	valine-tRNA ligase activity
FR838_RS06510	COG0004	ammonium transporteR
FR838_RS06525	COG0642	Histidine kinase
FR838_RS06530	COG0745	RESPONSE REGULATOR receiver
FR838_RS06535	COG2194	sulfuric ester hydrolase activity
FR838_RS06560	COG1752	Esterase of the alpha-beta hydrolase superfamily
FR838_RS06575	COG2315	Protein conserved in bacteria
FR838_RS06580	COG0142	geranyltranstransferase activity
FR838_RS06585	COG2828	Protein conserved in bacteria
FR838_RS06590	COG1113	amino acid transport
FR838_RS06600	COG3046	protein related to deoxyribodipyrimidine photolyase
FR838_RS06630	COG2207	Transcriptional regulator
FR838_RS06655	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR838_RS06675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FR838_RS06685	COG1530	ribonuclease E activity
FR838_RS06690	COG0424	maF-like protein
FR838_RS06695	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FR838_RS06700	COG1792	Involved in formation and maintenance of cell shape
FR838_RS06705	COG1077	Cell shape determining protein MreB Mrl
FR838_RS06710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FR838_RS06720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FR838_RS06745	COG3590	peptidase
FR838_RS06750	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FR838_RS06755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FR838_RS06760	COG1752	Esterase of the alpha-beta hydrolase superfamily
FR838_RS06765	COG1115	amino acid carrier protein
FR838_RS06790	COG2814	Major facilitator Superfamily
FR838_RS06795	COG1289	transmembrane transporter activity
FR838_RS06805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FR838_RS06845	COG1376	ErfK ybiS ycfS ynhG family protein
FR838_RS06850	COG2832	Protein of unknown function (DUF454)
FR838_RS06860	COG5510	response to toxic substance
FR838_RS06880	COG0840	transmembrane signaling receptor activity
FR838_RS06920	COG3422	double-strand break repair
FR838_RS06925	COG2824	Alkylphosphonate utilization operon protein PhnA
FR838_RS06930	COG3189	MarR family transcriptional regulator
FR838_RS06935	COG0596	Alpha beta hydrolase
FR838_RS06940	COG0778	Nitroreductase
FR838_RS06945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FR838_RS06950	COG1335	isochorismatase
FR838_RS06955	COG0251	oxidation-reduction process
FR838_RS06960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR838_RS06965	COG2233	PERMEase
FR838_RS06985	COG0354	folic acid binding
FR838_RS06990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR838_RS07000	COG0679	Auxin Efflux Carrier
FR838_RS07005	COG1902	pentaerythritol trinitrate reductase activity
FR838_RS07010	COG4772	TonB-dependent receptor
FR838_RS07015	COG2094	Belongs to the DNA glycosylase MPG family
FR838_RS07040	COG1217	gtp-binding protein TYPA
FR838_RS07045	COG2233	PERMEase
FR838_RS07055	COG0833	amino acid
FR838_RS07060	COG1690	Belongs to the RtcB family
FR838_RS07065	COG2885	chlorophyll binding
FR838_RS07065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FR838_RS07075	COG0183	Belongs to the thiolase family
FR838_RS07095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR838_RS07115	COG2207	Transcriptional regulator
FR838_RS07120	COG0183	Belongs to the thiolase family
FR838_RS07140	COG2153	protein acetylation
FR838_RS07150	COG1272	protein, Hemolysin III
FR838_RS07155	COG0477	Major facilitator Superfamily
FR838_RS07170	COG0450	alkyl hydroperoxide reductase
FR838_RS07190	COG0285	dihydrofolate synthase activity
FR838_RS07235	COG4206	TonB-dependent receptor
FR838_RS07240	COG2096	Adenosyltransferase
FR838_RS07260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FR838_RS07270	COG0745	RESPONSE REGULATOR receiver
FR838_RS07275	COG2205	protein histidine kinase activity
FR838_RS07285	COG1960	acyl-CoA dehydrogenase activity
FR838_RS07290	COG1960	acyl-CoA dehydrogenase activity
FR838_RS07295	COG0583	DNA-binding transcription factor activity
FR838_RS07300	COG0625	glutathione transferase activity
FR838_RS07350	COG1216	Glycosyl transferase, family 2
FR838_RS07365	COG0726	polysaccharide deacetylase
FR838_RS07380	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FR838_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR838_RS07385	COG2205	protein histidine kinase activity
FR838_RS07385	COG2198	Histidine kinase
FR838_RS07385	COG0784	Response regulator, receiver
FR838_RS07420	COG1862	Preprotein translocase
FR838_RS07430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR838_RS07435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FR838_RS07445	COG3781	membrane
FR838_RS07460	COG2350	Protein conserved in bacteria
FR838_RS07495	COG1607	acyl-coa hydrolase
FR838_RS07510	COG3328	transposase activity
FR838_RS07575	COG2199	diguanylate cyclase activity
FR838_RS07580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FR838_RS07580	COG2885	chlorophyll binding
FR838_RS07585	COG1408	metallophosphoesterase
FR838_RS07590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR838_RS07600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FR838_RS07620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FR838_RS07625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FR838_RS07630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FR838_RS07635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FR838_RS07640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FR838_RS07650	COG2969	positive regulation of protein catabolic process
FR838_RS07690	COG1960	acyl-CoA dehydrogenase activity
FR838_RS07695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR838_RS07710	COG1309	transcriptional regulator
FR838_RS07715	COG1960	acyl-CoA dehydrogenase activity
FR838_RS07760	COG1183	phosphatidylcholine synthase activity
FR838_RS07765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FR838_RS07795	COG0741	lytic transglycosylase activity
FR838_RS07795	COG1196	nuclear chromosome segregation
FR838_RS07795	COG0739	heme binding
FR838_RS07805	COG1702	phosphate starvation-inducible protein PhoH
FR838_RS07840	COG1295	ribonuclease BN
FR838_RS07845	COG0179	Fumarylacetoacetate (FAA) hydrolase
FR838_RS07895	COG0557	exoribonuclease II activity
FR838_RS07900	COG0339	signal peptide processing
FR838_RS07905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FR838_RS07935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FR838_RS07940	COG1960	acyl-CoA dehydrogenase activity
FR838_RS08075	COG0088	Forms part of the polypeptide exit tunnel
FR838_RS08080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FR838_RS08095	COG0626	cystathionine gamma-synthase activity
FR838_RS08100	COG0433	COG0433 Predicted ATPase
FR838_RS08110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR838_RS08110	COG1017	nitric oxide dioxygenase activity
FR838_RS08115	COG1959	2 iron, 2 sulfur cluster binding
FR838_RS08130	COG1301	dicarboxylic acid transport
FR838_RS08135	COG1946	Acyl-CoA thioesterase
FR838_RS08155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FR838_RS08160	COG1040	competence protein
FR838_RS08165	COG0494	nUDIX hydrolase
FR838_RS08175	COG0598	Magnesium transport protein CorA
FR838_RS08185	COG2854	intermembrane phospholipid transfer
FR838_RS08195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FR838_RS08200	COG1127	ABC transporter
FR838_RS08210	COG0513	Belongs to the DEAD box helicase family
FR838_RS08230	COG0408	coproporphyrinogen oxidase activity
FR838_RS08245	COG1960	acyl-CoA dehydrogenase activity
FR838_RS08255	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS08265	COG1983	PspC domain protein
FR838_RS08270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FR838_RS08270	COG0617	tRNA 3'-terminal CCA addition
FR838_RS08270	COG0517	IMP dehydrogenase activity
FR838_RS08290	COG0752	glycyl-tRNA synthetase alpha subunit
FR838_RS08320	COG0583	DNA-binding transcription factor activity
FR838_RS08360	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS08370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FR838_RS08375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FR838_RS08380	COG0833	amino acid
FR838_RS08410	COG1192	Involved in chromosome partitioning
FR838_RS08415	COG0628	permease
FR838_RS08425	COG1289	transmembrane transporter activity
FR838_RS08440	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR838_RS08445	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FR838_RS08455	COG0277	FAD linked oxidase domain protein
FR838_RS08460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FR838_RS08465	COG5006	permease, DMT superfamily
FR838_RS08470	COG5006	permease, DMT superfamily
FR838_RS08485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FR838_RS08490	COG5380	lipid catabolic process
FR838_RS08500	COG0335	large ribosomal subunit rRNA binding
FR838_RS08510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FR838_RS08560	COG0194	GDP metabolic process
FR838_RS08575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR838_RS08600	COG3307	-O-antigen
FR838_RS08610	COG3328	transposase activity
FR838_RS08630	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FR838_RS08635	COG1704	LemA family
FR838_RS08645	COG0493	'glutamate synthase
FR838_RS08650	COG0067	glutamate synthase
FR838_RS08650	COG0069	glutamate synthase activity
FR838_RS08650	COG0070	glutamate synthase
FR838_RS08700	COG2226	methyltransferase
FR838_RS08715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FR838_RS08720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FR838_RS08765	COG0833	amino acid
FR838_RS08850	COG0488	(ABC) transporter
FR838_RS08855	COG2873	o-acetylhomoserine
FR838_RS08860	COG4221	oxidoreductase activity
FR838_RS08865	COG0659	secondary active sulfate transmembrane transporter activity
FR838_RS08890	COG0427	acetyl-CoA hydrolase
FR838_RS08920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FR838_RS08930	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FR838_RS08940	COG1132	(ABC) transporter
FR838_RS08950	COG0697	spore germination
FR838_RS08955	COG2329	Antibiotic biosynthesis monooxygenase
FR838_RS08970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FR838_RS09030	COG0582	viral genome integration into host DNA
FR838_RS09095	COG2801	Transposase and inactivated derivatives
FR838_RS09140	COG3177	Filamentation induced by cAMP protein fic
FR838_RS09160	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS09180	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR838_RS09185	COG1733	regulation of RNA biosynthetic process
FR838_RS09195	COG3328	transposase activity
FR838_RS09210	COG1309	transcriptional regulator
FR838_RS09230	COG0667	Aldo Keto reductase
FR838_RS09250	COG0583	DNA-binding transcription factor activity
FR838_RS09255	COG2814	Major facilitator Superfamily
FR838_RS09295	COG1335	isochorismatase
FR838_RS09305	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS09310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR838_RS09320	COG1113	amino acid transport
FR838_RS09330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FR838_RS09345	COG2814	Major facilitator Superfamily
FR838_RS09355	COG0351	phosphomethylpyrimidine kinase
FR838_RS09355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FR838_RS09355	COG0352	thiamine-phosphate diphosphorylase activity
FR838_RS09360	COG0789	Transcriptional regulator
FR838_RS09365	COG0300	oxidoreductase activity
FR838_RS09385	COG1309	transcriptional regulator
FR838_RS09415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR838_RS09425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR838_RS09430	COG3162	membrane
FR838_RS09435	COG2198	Histidine kinase
FR838_RS09435	COG0784	Response regulator, receiver
FR838_RS09435	COG2205	protein histidine kinase activity
FR838_RS09460	COG1522	sequence-specific DNA binding
FR838_RS09465	COG1335	isochorismatase
FR838_RS09470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR838_RS09480	COG0668	transmembrane transport
FR838_RS09485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FR838_RS09490	COG1519	Transferase
FR838_RS09495	COG1902	pentaerythritol trinitrate reductase activity
FR838_RS09515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FR838_RS09535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR838_RS09535	COG0426	domain, Protein
FR838_RS09540	COG4774	siderophore transport
FR838_RS09545	COG2119	membrane
FR838_RS09555	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR838_RS09565	COG4942	peptidase
FR838_RS09580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FR838_RS09590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FR838_RS09610	COG0189	ligase activity
FR838_RS09630	COG0708	Exodeoxyribonuclease III
FR838_RS09635	COG1393	Belongs to the ArsC family
FR838_RS09650	COG3706	GGDEF domain
FR838_RS09685	COG2351	hydroxyisourate hydrolase activity
FR838_RS09690	COG2233	PERMEase
FR838_RS09700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR838_RS09710	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FR838_RS09720	COG3150	esterase
FR838_RS09740	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS09770	COG2918	glutathione biosynthetic process
FR838_RS09785	COG2733	membrane
FR838_RS09790	COG0436	Aminotransferase
FR838_RS09795	COG0534	Mate efflux family protein
FR838_RS09900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FR838_RS09905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FR838_RS09915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FR838_RS09955	COG0010	Belongs to the arginase family
FR838_RS09985	COG2188	Transcriptional regulator
FR838_RS09995	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS10005	COG0523	cobalamin synthesis protein
FR838_RS10015	COG1113	amino acid transport
FR838_RS10025	COG0625	glutathione transferase activity
FR838_RS10030	COG0346	lactoylglutathione lyase activity
FR838_RS10045	COG1683	Conserved Protein
FR838_RS10050	COG0534	Mate efflux family protein
FR838_RS10055	COG0385	Bile acid
FR838_RS10060	COG1335	isochorismatase
FR838_RS10065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR838_RS10085	COG2116	formate transmembrane transporter activity
FR838_RS10090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FR838_RS10095	COG2133	pyrroloquinoline quinone binding
FR838_RS10100	COG2983	Belongs to the UPF0260 family
FR838_RS10105	COG5487	UPF0391 membrane protein
FR838_RS10120	COG1194	a g-specific adenine glycosylase
FR838_RS10135	COG2818	Glycosylase
FR838_RS10140	COG1064	alcohol dehydrogenase
FR838_RS10145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR838_RS10160	COG0583	DNA-binding transcription factor activity
FR838_RS10165	COG0656	L-ascorbic acid biosynthetic process
FR838_RS10170	COG2814	Major facilitator Superfamily
FR838_RS10205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR838_RS10220	COG2233	PERMEase
FR838_RS10260	COG0733	neurotransmitter:sodium symporter activity
FR838_RS10270	COG0625	glutathione transferase activity
FR838_RS10305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FR838_RS10310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FR838_RS10315	COG0596	Alpha beta hydrolase
FR838_RS10340	COG0488	(ABC) transporter
FR838_RS10355	COG0187	DNA topoisomerase II activity
FR838_RS10365	COG0592	DNA-directed DNA polymerase activity
FR838_RS10390	COG0706	membrane insertase activity
FR838_RS10410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR838_RS10425	COG0402	S-adenosylhomocysteine deaminase activity
FR838_RS10435	COG0754	glutathionylspermidine amidase activity
FR838_RS10445	COG0861	Integral membrane protein TerC family
FR838_RS10450	COG0671	phosphoesterase, PA-phosphatase related
FR838_RS10460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FR838_RS10475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FR838_RS10480	COG2951	lytic endotransglycosylase activity
FR838_RS10530	COG0657	acetylesterase activity
FR838_RS10535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FR838_RS10575	COG1047	Peptidyl-prolyl cis-trans
FR838_RS10585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FR838_RS10590	COG0196	riboflavin kinase activity
FR838_RS10600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FR838_RS10605	COG1309	transcriptional regulator
FR838_RS10610	COG1116	anion transmembrane transporter activity
FR838_RS10615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR838_RS10620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FR838_RS10625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR838_RS10630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR838_RS10635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FR838_RS10635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FR838_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS10655	COG0546	phosphoglycolate phosphatase activity
FR838_RS10710	COG3023	N-Acetylmuramoyl-L-alanine amidase
FR838_RS10715	COG0728	peptidoglycan biosynthetic process
FR838_RS10745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FR838_RS10770	COG1091	dTDP-4-dehydrorhamnose reductase activity
FR838_RS10805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR838_RS10810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FR838_RS10825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR838_RS10835	COG2186	Transcriptional regulator
FR838_RS10845	COG0277	FAD linked oxidase domain protein
FR838_RS10850	COG1448	Aminotransferase
FR838_RS10860	COG1802	Transcriptional regulator
FR838_RS10875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FR838_RS10890	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS10960	COG0564	pseudouridine synthase activity
FR838_RS11000	COG0251	oxidation-reduction process
FR838_RS11005	COG1113	amino acid transport
FR838_RS11010	COG1113	amino acid transport
FR838_RS11030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR838_RS11035	COG1960	acyl-CoA dehydrogenase activity
FR838_RS11040	COG1024	Enoyl-CoA hydratase
FR838_RS11045	COG1024	Enoyl-CoA hydratase
FR838_RS11050	COG0477	Major facilitator Superfamily
FR838_RS11055	COG0697	spore germination
FR838_RS11060	COG1113	amino acid transport
FR838_RS11065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR838_RS11075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR838_RS11080	COG3916	Acyl-homoserine-lactone synthase
FR838_RS11090	COG2197	response regulator
FR838_RS11095	COG0318	PFAM AMP-dependent synthetase and ligase
FR838_RS11100	COG1960	acyl-CoA dehydrogenase activity
FR838_RS11105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FR838_RS11105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR838_RS11105	COG3321	synthase
FR838_RS11105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FR838_RS11135	COG0271	Belongs to the BolA IbaG family
FR838_RS11145	COG1192	Involved in chromosome partitioning
FR838_RS11160	COG0586	Pfam SNARE associated Golgi protein
FR838_RS11165	COG2259	Doxx family
FR838_RS11170	COG4399	Belongs to the UPF0754 family
FR838_RS11175	COG0519	Catalyzes the synthesis of GMP from XMP
FR838_RS11175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FR838_RS11235	COG0281	malic enzyme
FR838_RS11240	COG2837	iron assimilation
FR838_RS11245	COG1280	lysine exporter protein (LysE YggA)
FR838_RS11250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FR838_RS11255	COG1121	(ABC) transporter
FR838_RS11295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FR838_RS11305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FR838_RS11320	COG0386	Belongs to the glutathione peroxidase family
FR838_RS11335	COG1309	transcriptional regulator
FR838_RS11340	COG0697	spore germination
FR838_RS11350	COG0758	DNA mediated transformation
FR838_RS11385	COG1309	transcriptional regulator
FR838_RS11415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FR838_RS11430	COG0655	NAD(P)H dehydrogenase (quinone) activity
FR838_RS11470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR838_RS11480	COG2814	Major facilitator Superfamily
FR838_RS11490	COG1253	flavin adenine dinucleotide binding
FR838_RS11500	COG2860	membrane
FR838_RS11505	COG0477	Major facilitator Superfamily
FR838_RS11515	COG0318	PFAM AMP-dependent synthetase and ligase
FR838_RS11530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FR838_RS11550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR838_RS11555	COG0235	Class ii aldolase
FR838_RS11560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR838_RS11565	COG0431	NADPH-dependent FMN reductase
FR838_RS11570	COG0606	chelatase, subunit chli
FR838_RS11580	COG0347	Belongs to the P(II) protein family
FR838_RS11585	COG0004	ammonium transporteR
FR838_RS11595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR838_RS11595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR838_RS11635	COG0795	lipopolysaccharide-transporting ATPase activity
FR838_RS11640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FR838_RS11645	COG0793	Belongs to the peptidase S41A family
FR838_RS11660	COG2197	response regulator
FR838_RS11670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FR838_RS11680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR838_RS11685	COG4974	Belongs to the 'phage' integrase family
FR838_RS11710	COG0772	Belongs to the SEDS family
FR838_RS11715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR838_RS11720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FR838_RS11725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FR838_RS11730	COG0494	nUDIX hydrolase
FR838_RS11750	COG0697	spore germination
FR838_RS11760	COG1538	Outer membrane efflux protein
FR838_RS11780	COG3275	phosphorelay sensor kinase activity
FR838_RS11790	COG0181	hydroxymethylbilane synthase activity
FR838_RS11835	COG1716	ATPase activity
FR838_RS11840	COG0546	phosphoglycolate phosphatase activity
FR838_RS11870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FR838_RS11940	COG2056	Na+-H+ antiporter family
FR838_RS11965	COG0326	Molecular chaperone. Has ATPase activity
FR838_RS11980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FR838_RS12055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FR838_RS12060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FR838_RS12060	COG2169	Transcriptional regulator
FR838_RS12095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FR838_RS12105	COG0497	DNA recombination
FR838_RS12120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR838_RS12130	COG0237	dephospho-CoA kinase activity
FR838_RS12180	COG0195	Participates in both transcription termination and antitermination
FR838_RS12190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FR838_RS12195	COG1320	monovalent cation:proton antiporter activity
FR838_RS12200	COG2212	antiporter activity
FR838_RS12205	COG1863	multisubunit Na H antiporter MnhE subunit
FR838_RS12210	COG0651	ATP synthesis coupled electron transport
FR838_RS12215	COG1006	Multisubunit Na H antiporter MnhC subunit
FR838_RS12220	COG2111	Na H antiporter
FR838_RS12220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FR838_RS12235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FR838_RS12245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR838_RS12250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FR838_RS12260	COG2226	methyltransferase
FR838_RS12280	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FR838_RS12285	COG1074	ATP-dependent DNA helicase activity
FR838_RS12290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR838_RS12295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FR838_RS12305	COG1185	polyribonucleotide nucleotidyltransferase activity
FR838_RS12310	COG0598	Magnesium transport protein CorA
FR838_RS12315	COG0789	Transcriptional regulator
FR838_RS12320	COG0484	heat shock protein binding
FR838_RS12330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FR838_RS12340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FR838_RS12360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR838_RS12370	COG4535	Mg2 and Co2 transporter CorC
FR838_RS12385	COG0644	oxidoreductase
FR838_RS12385	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FR838_RS12395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FR838_RS12410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR838_RS12415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FR838_RS12425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR838_RS12425	COG0493	'glutamate synthase
FR838_RS12450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FR838_RS12465	COG0534	Mate efflux family protein
FR838_RS12475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FR838_RS12480	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS12485	COG0583	DNA-binding transcription factor activity
FR838_RS12500	COG0318	PFAM AMP-dependent synthetase and ligase
FR838_RS12505	COG1530	ribonuclease E activity
FR838_RS12520	COG0546	phosphoglycolate phosphatase activity
FR838_RS12525	COG2378	regulation of single-species biofilm formation
FR838_RS12530	COG0625	glutathione transferase activity
FR838_RS12540	COG0583	DNA-binding transcription factor activity
FR838_RS12580	COG0583	DNA-binding transcription factor activity
FR838_RS12605	COG0473	3-isopropylmalate dehydrogenase activity
FR838_RS12660	COG1301	dicarboxylic acid transport
FR838_RS12670	COG1560	Kdo2-lipid A biosynthetic process
FR838_RS12680	COG0488	(ABC) transporter
FR838_RS12685	COG2900	Belongs to the SlyX family
FR838_RS12695	COG1733	regulation of RNA biosynthetic process
FR838_RS12720	COG0210	DNA helicase
FR838_RS12725	COG0724	RNA recognition motif
FR838_RS12745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FR838_RS12745	COG4651	solute:proton antiporter activity
FR838_RS12770	COG0788	formyltetrahydrofolate deformylase activity
FR838_RS12870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR838_RS12870	COG2813	Specifically methylates the guanine in position
FR838_RS12880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FR838_RS12890	COG4774	siderophore transport
FR838_RS12900	COG0740	serine-type endopeptidase activity
FR838_RS12920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FR838_RS12920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FR838_RS12925	COG0857	belongs to the CobB CobQ family
FR838_RS12925	COG0280	phosphate acetyltransferase
FR838_RS12930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FR838_RS12945	COG0800	Aldolase
FR838_RS12955	COG3265	gluconokinase activity
FR838_RS12960	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS12970	COG2267	carboxylic ester hydrolase activity
FR838_RS12985	COG0793	Belongs to the peptidase S41A family
FR838_RS13020	COG1426	Protein conserved in bacteria
FR838_RS13040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR838_RS13060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FR838_RS13070	COG1162	GTPase activity
FR838_RS13075	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FR838_RS13105	COG0577	efflux transmembrane transporter activity
FR838_RS13105	COG1136	(ABC) transporter
FR838_RS13110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR838_RS13130	COG0028	Belongs to the TPP enzyme family
FR838_RS13135	COG0440	acetolactate synthase activity
FR838_RS13140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FR838_RS13160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FR838_RS13175	COG0084	hydrolase, TatD family'
FR838_RS13185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FR838_RS13195	COG0583	DNA-binding transcription factor activity
FR838_RS13210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR838_RS13295	COG2205	protein histidine kinase activity
FR838_RS13310	COG2132	Multicopper oxidase
FR838_RS13325	COG3328	transposase activity
FR838_RS13340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR838_RS13385	COG0640	Transcriptional regulator
FR838_RS13395	COG0798	PFAM Bile acid sodium symporter
FR838_RS13400	COG0431	NADPH-dependent FMN reductase
FR838_RS13405	COG0492	ferredoxin-NADP+ reductase activity
FR838_RS13410	COG2072	flavoprotein involved in K transport
FR838_RS13450	COG2814	Major facilitator Superfamily
FR838_RS13460	COG0697	spore germination
FR838_RS13490	COG3622	Belongs to the hyi family
FR838_RS13495	COG2084	Dehydrogenase
FR838_RS13500	COG1024	Enoyl-CoA hydratase
FR838_RS13505	COG5002	protein histidine kinase activity
FR838_RS13505	COG2205	protein histidine kinase activity
FR838_RS13505	COG0784	Response regulator, receiver
FR838_RS13510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FR838_RS13525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR838_RS13530	COG4221	oxidoreductase activity
FR838_RS13535	COG3956	TIGRFAM MazG family protein
FR838_RS13540	COG1555	photosystem II stabilization
FR838_RS13545	COG0617	tRNA 3'-terminal CCA addition
FR838_RS13550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FR838_RS13570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR838_RS13575	COG3028	Belongs to the UPF0307 family
FR838_RS13580	COG0318	PFAM AMP-dependent synthetase and ligase
FR838_RS13600	COG0625	glutathione transferase activity
FR838_RS13605	COG1238	metal cluster binding
FR838_RS13620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FR838_RS13650	COG0072	phenylalanine-tRNA ligase activity
FR838_RS13680	COG0248	Ppx GppA phosphatase
FR838_RS13690	COG0037	tRNA processing
FR838_RS13730	COG1764	response to oxidative stress
FR838_RS13735	COG1846	Transcriptional regulator
FR838_RS13745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR838_RS13805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FR838_RS13810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FR838_RS13815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FR838_RS13875	COG1214	PFAM Peptidase M22, glycoprotease
FR838_RS13900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FR838_RS13905	COG0561	phosphatase activity
FR838_RS13915	COG2132	Multicopper oxidase
FR838_RS13935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FR838_RS13940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FR838_RS13945	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FR838_RS13980	COG1063	alcohol dehydrogenase
FR838_RS13985	COG0583	DNA-binding transcription factor activity
FR838_RS13990	COG1960	acyl-CoA dehydrogenase activity
FR838_RS13995	COG2814	Major facilitator Superfamily
FR838_RS14000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FR838_RS14010	COG1309	transcriptional regulator
FR838_RS14025	COG1053	succinate dehydrogenase
FR838_RS14030	COG0583	DNA-binding transcription factor activity
FR838_RS14050	COG0583	DNA-binding transcription factor activity
FR838_RS14100	COG0583	DNA-binding transcription factor activity
FR838_RS14115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR838_RS14165	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS14175	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS14200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FR838_RS14215	COG0745	RESPONSE REGULATOR receiver
FR838_RS14255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FR838_RS14285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FR838_RS14290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FR838_RS14310	COG0583	DNA-binding transcription factor activity
FR838_RS14330	COG0668	transmembrane transport
FR838_RS14340	COG2081	HI0933 family
FR838_RS14345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FR838_RS14380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR838_RS14380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR838_RS14390	COG0489	protein tyrosine kinase activity
FR838_RS14395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FR838_RS14445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR838_RS14455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FR838_RS14470	COG0730	response to heat
FR838_RS14480	COG1196	nuclear chromosome segregation
FR838_RS14500	COG2223	nitrite transmembrane transporter activity
FR838_RS14505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FR838_RS14515	COG2226	methyltransferase
FR838_RS14515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR838_RS14515	COG0596	Alpha beta hydrolase
FR838_RS14530	COG4106	trans-aconitate 2-methyltransferase activity
FR838_RS14545	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FR838_RS14550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FR838_RS14555	COG0009	L-threonylcarbamoyladenylate synthase
FR838_RS14560	COG3101	peptidyl-lysine hydroxylation
FR838_RS14565	COG1399	metal-binding, possibly nucleic acid-binding protein
FR838_RS14590	COG1652	LysM domain
FR838_RS14595	COG0351	phosphomethylpyrimidine kinase
FR838_RS14595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FR838_RS14595	COG0352	thiamine-phosphate diphosphorylase activity
FR838_RS14605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR838_RS14635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FR838_RS14665	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FR838_RS14680	COG0358	DNA primase activity
FR838_RS14715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR838_RS14735	COG0583	DNA-binding transcription factor activity
FR838_RS14740	COG0473	3-isopropylmalate dehydrogenase activity
FR838_RS14750	COG0657	acetylesterase activity
FR838_RS14755	COG4638	Rieske (2fe-2S)
FR838_RS14760	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS14780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR838_RS14780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FR838_RS14790	COG1981	membrane
FR838_RS14805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FR838_RS14815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FR838_RS14820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FR838_RS14835	COG0456	acetyltransferase
FR838_RS14845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FR838_RS14850	COG0492	ferredoxin-NADP+ reductase activity
FR838_RS14855	COG1674	ftsk spoiiie
FR838_RS14860	COG1280	lysine exporter protein (LysE YggA)
FR838_RS14890	COG2894	cell division
FR838_RS14905	COG0204	Acyl-transferase
FR838_RS14910	COG2885	chlorophyll binding
FR838_RS14915	COG0210	DNA helicase
FR838_RS14925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR838_RS14940	COG0121	glutamine amidotransferase
FR838_RS14960	COG2914	Belongs to the UPF0125 (RnfH) family
FR838_RS14965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR838_RS14970	COG0735	belongs to the Fur family
FR838_RS14995	COG0420	3'-5' exonuclease activity
FR838_RS15015	COG1090	epimerase
FR838_RS15030	COG2050	protein possibly involved in aromatic compounds catabolism
FR838_RS15040	COG2814	Major facilitator Superfamily
FR838_RS15045	COG0405	Gamma-glutamyltransferase
FR838_RS15095	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS15140	COG0477	Major facilitator Superfamily
FR838_RS15145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR838_RS15155	COG1595	DNA-templated transcription, initiation
FR838_RS15170	COG3328	transposase activity
FR838_RS15220	COG0531	amino acid
FR838_RS15225	COG2040	homocysteine
FR838_RS15250	COG1309	transcriptional regulator
FR838_RS15255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR838_RS15260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR838_RS15270	COG1607	acyl-coa hydrolase
FR838_RS15280	COG0523	cobalamin synthesis protein
FR838_RS15290	COG4681	YaeQ
FR838_RS15300	COG1649	PFAM Uncharacterised BCR, COG1649
FR838_RS15300	COG0726	polysaccharide deacetylase
FR838_RS15305	COG1215	transferase activity, transferring glycosyl groups
FR838_RS15330	COG1414	Transcriptional regulator
FR838_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS15365	COG2271	Major facilitator Superfamily
FR838_RS15375	COG2267	carboxylic ester hydrolase activity
FR838_RS15380	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS15395	COG0028	Belongs to the TPP enzyme family
FR838_RS15405	COG0477	Major facilitator Superfamily
FR838_RS15410	COG0242	peptide deformylase activity
FR838_RS15415	COG2066	Belongs to the glutaminase family
FR838_RS15420	COG2207	Transcriptional regulator
FR838_RS15425	COG2223	nitrite transmembrane transporter activity
FR838_RS15455	COG0306	phosphate transporter
FR838_RS15475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FR838_RS15520	COG4181	ATPase activity
FR838_RS15525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FR838_RS15555	COG0583	DNA-binding transcription factor activity
FR838_RS15560	COG2267	carboxylic ester hydrolase activity
FR838_RS15565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR838_RS15570	COG1773	rubredoxin
FR838_RS15620	COG2851	Citrate transporter
FR838_RS15625	COG1253	flavin adenine dinucleotide binding
FR838_RS15640	COG3015	lipoprotein NlpE involved in copper resistance
FR838_RS15670	COG0804	urea catabolic process
FR838_RS15680	COG0830	nickel cation binding
FR838_RS15695	COG0742	ribosomal rna small subunit methyltransferase
FR838_RS15700	COG0768	penicillin binding
FR838_RS15725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FR838_RS15730	COG2878	Part of a membrane complex involved in electron transport
FR838_RS15735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FR838_RS15755	COG3384	dioxygenase
FR838_RS15770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FR838_RS15810	COG0006	proline dipeptidase activity
FR838_RS15815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR838_RS15820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR838_RS15840	COG1279	arginine transmembrane transporter activity
FR838_RS15845	COG0583	DNA-binding transcription factor activity
FR838_RS15890	COG1388	LysM domain
FR838_RS15890	COG0741	lytic transglycosylase activity
FR838_RS15895	COG4166	transmembrane transport
FR838_RS15900	COG4174	ABC transporter (Permease)
FR838_RS15905	COG4239	(ABC) transporter, permease
FR838_RS15910	COG4172	Belongs to the ABC transporter superfamily
FR838_RS15935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FR838_RS15945	COG2203	Gaf domain
FR838_RS15945	COG3706	GGDEF domain
FR838_RS15945	COG5001	Diguanylate cyclase
FR838_RS15945	COG4251	negative regulation of phosphorylation
FR838_RS15955	COG1902	pentaerythritol trinitrate reductase activity
FR838_RS15955	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR838_RS15965	COG0582	viral genome integration into host DNA
FR838_RS16025	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FR838_RS16030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR838_RS16040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR838_RS16105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FR838_RS16110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FR838_RS16175	COG4269	membrane
FR838_RS16185	COG2801	Transposase and inactivated derivatives
FR838_RS16220	COG1113	amino acid transport
FR838_RS16230	COG0531	amino acid
FR838_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS16280	COG1113	amino acid transport
FR838_RS16300	COG0697	spore germination
FR838_RS16305	COG2721	sulfolactate sulfo-lyase activity
FR838_RS16310	COG2271	Major facilitator Superfamily
FR838_RS16315	COG4948	Mandelate Racemase Muconate Lactonizing
FR838_RS16325	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS16330	COG2186	Transcriptional regulator
FR838_RS16355	COG1960	acyl-CoA dehydrogenase activity
FR838_RS16370	COG1024	Enoyl-CoA hydratase
FR838_RS16375	COG2814	Major facilitator Superfamily
FR838_RS16390	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS16395	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FR838_RS16405	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS16415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR838_RS16430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FR838_RS16450	COG1944	ATP diphosphatase activity
FR838_RS16480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FR838_RS16495	COG0583	DNA-binding transcription factor activity
FR838_RS16500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FR838_RS16505	COG2072	flavoprotein involved in K transport
FR838_RS16520	COG1309	transcriptional regulator
FR838_RS16525	COG1741	Belongs to the pirin family
FR838_RS16535	COG2252	PERMEase
FR838_RS16540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FR838_RS16545	COG3038	cytochrome b561
FR838_RS16555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FR838_RS16565	COG0527	aspartate kinase activity
FR838_RS16760	COG1598	PFAM Uncharacterised protein family UPF0150
FR838_RS16775	COG0741	lytic transglycosylase activity
FR838_RS16775	COG0739	heme binding
FR838_RS16775	COG1196	nuclear chromosome segregation
FR838_RS16805	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS16840	COG1063	alcohol dehydrogenase
FR838_RS16845	COG3293	Transposase
FR838_RS16875	COG0582	viral genome integration into host DNA
FR838_RS16885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FR838_RS16895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FR838_RS16910	COG0667	Aldo Keto reductase
FR838_RS16925	COG1765	OsmC-like protein
FR838_RS16940	COG0542	response to heat
FR838_RS16965	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS16990	COG2885	chlorophyll binding
FR838_RS17000	COG0625	glutathione transferase activity
FR838_RS17005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FR838_RS17025	COG3634	alkyl hydroperoxide reductase activity
FR838_RS17050	COG1643	Atp-dependent helicase
FR838_RS17070	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS17080	COG3135	benzoate transporter
FR838_RS17085	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS17090	COG0543	2 iron, 2 sulfur cluster binding
FR838_RS17090	COG0633	Ferredoxin
FR838_RS17095	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FR838_RS17100	COG4638	Rieske (2fe-2S)
FR838_RS17110	COG0583	DNA-binding transcription factor activity
FR838_RS17120	COG2871	sodium ion transport
FR838_RS17205	COG1570	exodeoxyribonuclease VII activity
FR838_RS17245	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS17250	COG1280	lysine exporter protein (LysE YggA)
FR838_RS17255	COG1560	Kdo2-lipid A biosynthetic process
FR838_RS17260	COG1278	Cold shock
FR838_RS17290	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS17295	COG2226	methyltransferase
FR838_RS17305	COG1309	transcriptional regulator
FR838_RS17350	COG0668	transmembrane transport
FR838_RS17360	COG2814	Major facilitator Superfamily
FR838_RS17395	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS17420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FR838_RS17430	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FR838_RS17435	COG1137	ATPase activity
FR838_RS17440	COG1538	Outer membrane efflux protein
FR838_RS17470	COG4122	O-methyltransferase activity
FR838_RS17480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FR838_RS17495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR838_RS17510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FR838_RS17560	COG3220	belongs to the UPF0276 family
FR838_RS17570	COG1595	DNA-templated transcription, initiation
FR838_RS17585	COG1914	H( )-stimulated, divalent metal cation uptake system
FR838_RS17605	COG4770	biotin carboxylase activity
FR838_RS17610	COG0038	chloride channel
FR838_RS17660	COG1250	3-hydroxyacyl-CoA dehydrogenase
FR838_RS17665	COG1063	alcohol dehydrogenase
FR838_RS17680	COG4770	biotin carboxylase activity
FR838_RS17705	COG0666	response to abiotic stimulus
FR838_RS17710	COG0590	tRNA wobble adenosine to inosine editing
FR838_RS17715	COG2807	transmembrane transport
FR838_RS17730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR838_RS17735	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FR838_RS17745	COG0789	Transcriptional regulator
FR838_RS17765	COG1760	l-serine dehydratase
FR838_RS17770	COG1012	belongs to the aldehyde dehydrogenase family
FR838_RS17770	COG2030	dehydratase
FR838_RS17775	COG3396	Phenylacetate-CoA oxygenase
FR838_RS17780	COG3460	Phenylacetate-CoA oxygenase
FR838_RS17785	COG3396	Phenylacetate-CoA oxygenase
FR838_RS17790	COG2151	metal-sulfur cluster biosynthetic enzyme
FR838_RS17795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR838_RS17800	COG1024	Enoyl-CoA hydratase
FR838_RS17805	COG1024	Enoyl-CoA hydratase
FR838_RS17810	COG1250	3-hydroxyacyl-CoA dehydrogenase
FR838_RS17815	COG0183	Belongs to the thiolase family
FR838_RS17820	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FR838_RS17825	COG3327	negative regulation of DNA-templated transcription, initiation
FR838_RS17835	COG2050	protein possibly involved in aromatic compounds catabolism
FR838_RS17840	COG0583	DNA-binding transcription factor activity
FR838_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS17865	COG3328	transposase activity
FR838_RS17880	COG0583	DNA-binding transcription factor activity
FR838_RS17890	COG1414	Transcriptional regulator
FR838_RS17895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR838_RS17910	COG1840	ABC-type Fe3 transport system, periplasmic component
FR838_RS17915	COG3842	ATPase activity
FR838_RS17930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FR838_RS17935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR838_RS17940	COG2814	Major facilitator Superfamily
FR838_RS17945	COG1960	acyl-CoA dehydrogenase activity
FR838_RS17960	COG1024	Enoyl-CoA hydratase
FR838_RS17970	COG2814	Major facilitator Superfamily
FR838_RS17980	COG0183	Belongs to the thiolase family
FR838_RS17985	COG1250	3-hydroxyacyl-CoA dehydrogenase
FR838_RS17990	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS17995	COG1024	Enoyl-CoA hydratase
FR838_RS18000	COG1960	acyl-CoA dehydrogenase activity
FR838_RS18005	COG2814	Major facilitator Superfamily
FR838_RS18010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FR838_RS18015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FR838_RS18025	COG2814	Major facilitator Superfamily
FR838_RS18035	COG1960	acyl-CoA dehydrogenase activity
FR838_RS18050	COG0583	DNA-binding transcription factor activity
FR838_RS18060	COG4770	biotin carboxylase activity
FR838_RS18065	COG1024	Enoyl-CoA hydratase
FR838_RS18070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR838_RS18075	COG1960	acyl-CoA dehydrogenase activity
FR838_RS18080	COG1309	transcriptional regulator
FR838_RS18085	COG0318	PFAM AMP-dependent synthetase and ligase
FR838_RS18100	COG2814	Major facilitator Superfamily
FR838_RS18115	COG0583	DNA-binding transcription factor activity
FR838_RS18150	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS18170	COG1028	Short-chain dehydrogenase reductase Sdr
FR838_RS18190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FR838_RS18210	COG0784	Response regulator, receiver
FR838_RS18210	COG2205	protein histidine kinase activity
FR838_RS18230	COG0765	amino acid transport
FR838_RS18235	COG0765	amino acid transport
FR838_RS18245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR838_RS18250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR838_RS18265	COG1280	lysine exporter protein (LysE YggA)
FR838_RS18270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FR838_RS18275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR838_RS18280	COG1045	serine acetyltransferase
FR838_RS18295	COG0583	DNA-binding transcription factor activity
FR838_RS18395	COG4397	Mu-like prophage major head subunit gpT
FR838_RS18410	COG5005	Phage virion morphogenesis
FR838_RS18415	COG2369	cell adhesion
FR838_RS18420	COG4383	Mu-like prophage protein gp29
FR838_RS18480	COG1846	Transcriptional regulator
FR838_RS18565	COG0625	glutathione transferase activity
FR838_RS18570	COG0625	glutathione transferase activity
FR838_RS18575	COG0583	DNA-binding transcription factor activity
FR838_RS18585	COG1346	cytolysis
FR838_RS18610	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FR838_RS18615	COG3052	prosthetic group binding
FR838_RS18635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FR838_RS18645	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS18665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR838_RS18675	COG1294	oxidase, subunit
FR838_RS18680	COG1271	oxidase subunit
FR838_RS18705	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS18710	COG0477	Major facilitator Superfamily
FR838_RS18720	COG4521	taurine ABC transporter
FR838_RS18725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FR838_RS18730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR838_RS18735	COG2175	clavaminate synthase activity
FR838_RS18745	COG1953	Uracil, thiamine, allantoin
FR838_RS18755	COG0583	DNA-binding transcription factor activity
FR838_RS18765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FR838_RS18780	COG0640	Transcriptional regulator
FR838_RS18790	COG0798	PFAM Bile acid sodium symporter
FR838_RS18795	COG0431	NADPH-dependent FMN reductase
FR838_RS18800	COG0583	DNA-binding transcription factor activity
FR838_RS18815	COG3634	alkyl hydroperoxide reductase activity
FR838_RS18850	COG1301	dicarboxylic acid transport
FR838_RS18855	COG0436	Aminotransferase
FR838_RS18865	COG0386	Belongs to the glutathione peroxidase family
FR838_RS18870	COG1917	Cupin 2, conserved barrel domain protein
FR838_RS18870	COG2207	Transcriptional regulator
FR838_RS18915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FR838_RS18940	COG0012	GTP binding
FR838_RS18945	COG2011	ABC-type metal ion transport system permease component
FR838_RS18950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FR838_RS18980	COG1660	Displays ATPase and GTPase activities
FR838_RS19090	COG0860	N-Acetylmuramoyl-L-alanine amidase
FR838_RS19195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FR838_RS19270	COG1525	nuclease
FR838_RS19320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FR838_RS19420	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS19430	COG2826	transposase and inactivated derivatives, IS30 family
FR838_RS19490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR838_RS19540	COG3657	addiction module killer protein
FR838_RS19545	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR838_RS19560	COG2801	Transposase and inactivated derivatives
FR838_RS19575	COG0488	(ABC) transporter
FR838_RS19580	COG3173	Aminoglycoside phosphotransferase
FR838_RS19590	COG0583	DNA-binding transcription factor activity
FR838_RS19610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FR838_RS19705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FR838_RS19855	COG1475	DNA binding
FR838_RS19860	COG1192	Involved in chromosome partitioning
FR838_RS20150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FR838_RS20155	COG2801	Transposase and inactivated derivatives
FR838_RS20175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR838_RS20185	COG5002	protein histidine kinase activity
FR838_RS20190	COG0745	RESPONSE REGULATOR receiver
FR838_RS20280	COG3077	Addiction module antitoxin, RelB DinJ family
FR838_RS20300	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FR838_RS20330	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FR838_RS20365	COG2184	nucleotidyltransferase activity
FR838_RS20400	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
FR838_RS20505	COG1785	Belongs to the alkaline phosphatase family
FR838_RS20510	COG1475	DNA binding
FR838_RS20515	COG1192	Involved in chromosome partitioning
FR838_RS20545	COG0604	alcohol dehydrogenase
FR838_RS20575	COG0582	viral genome integration into host DNA
FR838_RS20590	COG2130	NADP-dependent
FR838_RS20595	COG1309	transcriptional regulator
FR838_RS20605	COG1902	pentaerythritol trinitrate reductase activity
FR838_RS20615	COG1979	alcohol dehydrogenase
FR838_RS20630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FR838_RS20660	COG0477	Major facilitator Superfamily
FR838_RS20665	COG0697	spore germination
FR838_RS20675	COG0604	alcohol dehydrogenase
FR838_RS20675	COG3321	synthase
FR838_RS20680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FR838_RS20685	COG0583	DNA-binding transcription factor activity
FR838_RS20690	COG4221	oxidoreductase activity
FR838_RS20800	COG1252	NADH dehydrogenase
FR838_RS20805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FR838_RS20880	COG4115	mRNA cleavage