locus-tag	class	description
I6J45_RS00020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J45_RS00030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J45_RS00035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J45_RS00135	COG0534	Mate efflux family protein
I6J45_RS00140	COG0436	Aminotransferase
I6J45_RS00145	COG2733	membrane
I6J45_RS00160	COG2918	glutathione biosynthetic process
I6J45_RS00210	COG3150	esterase
I6J45_RS00220	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6J45_RS00230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J45_RS00240	COG2233	PERMEase
I6J45_RS00245	COG2351	hydroxyisourate hydrolase activity
I6J45_RS00280	COG3706	GGDEF domain
I6J45_RS00295	COG1393	Belongs to the ArsC family
I6J45_RS00300	COG0708	Exodeoxyribonuclease III
I6J45_RS00320	COG0189	ligase activity
I6J45_RS00340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J45_RS00350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J45_RS00365	COG4942	peptidase
I6J45_RS00375	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J45_RS00385	COG2119	membrane
I6J45_RS00390	COG4774	siderophore transport
I6J45_RS00395	COG0426	domain, Protein
I6J45_RS00395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J45_RS00415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J45_RS00435	COG1902	pentaerythritol trinitrate reductase activity
I6J45_RS00440	COG1519	Transferase
I6J45_RS00450	COG0668	transmembrane transport
I6J45_RS00460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J45_RS00465	COG1335	isochorismatase
I6J45_RS00470	COG1522	sequence-specific DNA binding
I6J45_RS00495	COG2205	protein histidine kinase activity
I6J45_RS00495	COG2198	Histidine kinase
I6J45_RS00495	COG0784	Response regulator, receiver
I6J45_RS00500	COG3162	membrane
I6J45_RS00505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J45_RS00515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J45_RS00535	COG1309	transcriptional regulator
I6J45_RS00555	COG0352	thiamine-phosphate diphosphorylase activity
I6J45_RS00555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J45_RS00555	COG0351	phosphomethylpyrimidine kinase
I6J45_RS00565	COG2814	Major facilitator Superfamily
I6J45_RS00580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J45_RS00600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J45_RS00605	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS00615	COG1335	isochorismatase
I6J45_RS00655	COG2814	Major facilitator Superfamily
I6J45_RS00660	COG0583	DNA-binding transcription factor activity
I6J45_RS00680	COG0667	Aldo Keto reductase
I6J45_RS00695	COG1309	transcriptional regulator
I6J45_RS00710	COG1733	regulation of RNA biosynthetic process
I6J45_RS00715	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J45_RS00725	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6J45_RS00730	COG2207	Transcriptional regulator
I6J45_RS00790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J45_RS00805	COG2329	Antibiotic biosynthesis monooxygenase
I6J45_RS00825	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6J45_RS00835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J45_RS00865	COG0427	acetyl-CoA hydrolase
I6J45_RS00890	COG0659	secondary active sulfate transmembrane transporter activity
I6J45_RS00895	COG4221	oxidoreductase activity
I6J45_RS00900	COG2873	o-acetylhomoserine
I6J45_RS00905	COG0488	(ABC) transporter
I6J45_RS00985	COG0833	amino acid
I6J45_RS01030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J45_RS01035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J45_RS01050	COG2226	methyltransferase
I6J45_RS01100	COG0070	glutamate synthase
I6J45_RS01100	COG0069	glutamate synthase activity
I6J45_RS01100	COG0067	glutamate synthase
I6J45_RS01105	COG0493	'glutamate synthase
I6J45_RS01115	COG1704	LemA family
I6J45_RS01120	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J45_RS01140	COG3307	-O-antigen
I6J45_RS01165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J45_RS01180	COG0194	GDP metabolic process
I6J45_RS01230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J45_RS01240	COG0335	large ribosomal subunit rRNA binding
I6J45_RS01250	COG5380	lipid catabolic process
I6J45_RS01255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J45_RS01275	COG5006	permease, DMT superfamily
I6J45_RS01280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J45_RS01285	COG0277	FAD linked oxidase domain protein
I6J45_RS01305	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J45_RS01310	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J45_RS01325	COG1289	transmembrane transporter activity
I6J45_RS01335	COG0628	permease
I6J45_RS01340	COG1192	Involved in chromosome partitioning
I6J45_RS01370	COG0833	amino acid
I6J45_RS01375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J45_RS01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J45_RS01390	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS01430	COG0583	DNA-binding transcription factor activity
I6J45_RS01455	COG0752	glycyl-tRNA synthetase alpha subunit
I6J45_RS01475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J45_RS01475	COG0617	tRNA 3'-terminal CCA addition
I6J45_RS01475	COG0517	IMP dehydrogenase activity
I6J45_RS01480	COG1983	PspC domain protein
I6J45_RS01490	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS01505	COG0408	coproporphyrinogen oxidase activity
I6J45_RS01525	COG0513	Belongs to the DEAD box helicase family
I6J45_RS01535	COG1127	ABC transporter
I6J45_RS01540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J45_RS01550	COG2854	intermembrane phospholipid transfer
I6J45_RS01560	COG0598	Magnesium transport protein CorA
I6J45_RS01570	COG0494	nUDIX hydrolase
I6J45_RS01575	COG1040	competence protein
I6J45_RS01580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J45_RS01600	COG1946	Acyl-CoA thioesterase
I6J45_RS01605	COG1301	dicarboxylic acid transport
I6J45_RS01620	COG1959	2 iron, 2 sulfur cluster binding
I6J45_RS01625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J45_RS01625	COG1017	nitric oxide dioxygenase activity
I6J45_RS01635	COG0433	COG0433 Predicted ATPase
I6J45_RS01640	COG0626	cystathionine gamma-synthase activity
I6J45_RS01655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J45_RS01660	COG0088	Forms part of the polypeptide exit tunnel
I6J45_RS01795	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS01800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J45_RS01830	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J45_RS01835	COG0339	signal peptide processing
I6J45_RS01840	COG0557	exoribonuclease II activity
I6J45_RS01890	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J45_RS01895	COG1295	ribonuclease BN
I6J45_RS01930	COG1702	phosphate starvation-inducible protein PhoH
I6J45_RS01940	COG0741	lytic transglycosylase activity
I6J45_RS01940	COG1196	nuclear chromosome segregation
I6J45_RS01940	COG0739	heme binding
I6J45_RS01970	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J45_RS01975	COG1183	phosphatidylcholine synthase activity
I6J45_RS02020	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS02025	COG1309	transcriptional regulator
I6J45_RS02040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J45_RS02045	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS02085	COG2969	positive regulation of protein catabolic process
I6J45_RS02095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J45_RS02100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J45_RS02105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J45_RS02110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J45_RS02115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J45_RS02135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J45_RS02145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J45_RS02150	COG1408	metallophosphoesterase
I6J45_RS02155	COG2885	chlorophyll binding
I6J45_RS02155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J45_RS02160	COG2199	diguanylate cyclase activity
I6J45_RS02205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J45_RS02230	COG1607	acyl-coa hydrolase
I6J45_RS02265	COG2350	Protein conserved in bacteria
I6J45_RS02280	COG3781	membrane
I6J45_RS02290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J45_RS02295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J45_RS02305	COG1862	Preprotein translocase
I6J45_RS02325	COG2198	Histidine kinase
I6J45_RS02325	COG2205	protein histidine kinase activity
I6J45_RS02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J45_RS02325	COG0784	Response regulator, receiver
I6J45_RS02330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J45_RS02345	COG0726	polysaccharide deacetylase
I6J45_RS02360	COG1216	Glycosyl transferase, family 2
I6J45_RS02410	COG0625	glutathione transferase activity
I6J45_RS02415	COG0583	DNA-binding transcription factor activity
I6J45_RS02420	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS02425	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS02435	COG2205	protein histidine kinase activity
I6J45_RS02440	COG0745	RESPONSE REGULATOR receiver
I6J45_RS02450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6J45_RS02470	COG2096	Adenosyltransferase
I6J45_RS02475	COG4206	TonB-dependent receptor
I6J45_RS02520	COG0285	dihydrofolate synthase activity
I6J45_RS02540	COG0450	alkyl hydroperoxide reductase
I6J45_RS02555	COG0477	Major facilitator Superfamily
I6J45_RS02560	COG1272	protein, Hemolysin III
I6J45_RS02570	COG2153	protein acetylation
I6J45_RS02590	COG0183	Belongs to the thiolase family
I6J45_RS02595	COG2207	Transcriptional regulator
I6J45_RS02615	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J45_RS02635	COG0183	Belongs to the thiolase family
I6J45_RS02645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J45_RS02645	COG2885	chlorophyll binding
I6J45_RS02655	COG1690	Belongs to the RtcB family
I6J45_RS02660	COG0833	amino acid
I6J45_RS02670	COG2233	PERMEase
I6J45_RS02675	COG1217	gtp-binding protein TYPA
I6J45_RS02700	COG2094	Belongs to the DNA glycosylase MPG family
I6J45_RS02705	COG4772	TonB-dependent receptor
I6J45_RS02710	COG1902	pentaerythritol trinitrate reductase activity
I6J45_RS02715	COG0679	Auxin Efflux Carrier
I6J45_RS02725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J45_RS02730	COG0354	folic acid binding
I6J45_RS02750	COG2233	PERMEase
I6J45_RS02755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J45_RS02760	COG0251	oxidation-reduction process
I6J45_RS02765	COG1335	isochorismatase
I6J45_RS02770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J45_RS02775	COG0778	Nitroreductase
I6J45_RS02780	COG0596	Alpha beta hydrolase
I6J45_RS02785	COG3189	MarR family transcriptional regulator
I6J45_RS02790	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J45_RS02795	COG3422	double-strand break repair
I6J45_RS02835	COG0840	transmembrane signaling receptor activity
I6J45_RS02855	COG5510	response to toxic substance
I6J45_RS02865	COG2832	Protein of unknown function (DUF454)
I6J45_RS02870	COG1376	ErfK ybiS ycfS ynhG family protein
I6J45_RS02910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J45_RS02920	COG1289	transmembrane transporter activity
I6J45_RS02925	COG2814	Major facilitator Superfamily
I6J45_RS02945	COG1115	amino acid carrier protein
I6J45_RS02950	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J45_RS02955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J45_RS02960	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J45_RS02965	COG3590	peptidase
I6J45_RS02990	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J45_RS03000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J45_RS03005	COG1077	Cell shape determining protein MreB Mrl
I6J45_RS03010	COG1792	Involved in formation and maintenance of cell shape
I6J45_RS03015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J45_RS03020	COG0424	maF-like protein
I6J45_RS03025	COG1530	ribonuclease E activity
I6J45_RS03035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J45_RS03055	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J45_RS03080	COG2207	Transcriptional regulator
I6J45_RS03110	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J45_RS03120	COG1113	amino acid transport
I6J45_RS03125	COG2828	Protein conserved in bacteria
I6J45_RS03130	COG0142	geranyltranstransferase activity
I6J45_RS03135	COG2315	Protein conserved in bacteria
I6J45_RS03150	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J45_RS03175	COG2194	sulfuric ester hydrolase activity
I6J45_RS03180	COG0745	RESPONSE REGULATOR receiver
I6J45_RS03185	COG0642	Histidine kinase
I6J45_RS03200	COG0004	ammonium transporteR
I6J45_RS03205	COG0583	DNA-binding transcription factor activity
I6J45_RS03230	COG0525	valine-tRNA ligase activity
I6J45_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS03250	COG0393	Putative heavy-metal-binding
I6J45_RS03255	COG0393	Putative heavy-metal-binding
I6J45_RS03260	COG1538	Outer membrane efflux protein
I6J45_RS03270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J45_RS03275	COG0671	phosphoesterase, PA-phosphatase related
I6J45_RS03300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J45_RS03315	COG1648	precorrin-2 dehydrogenase activity
I6J45_RS03315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J45_RS03320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J45_RS03355	COG0531	amino acid
I6J45_RS03370	COG0321	lipoyl(octanoyl) transferase activity
I6J45_RS03375	COG2921	Belongs to the UPF0250 family
I6J45_RS03415	COG2009	succinate dehydrogenase
I6J45_RS03420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J45_RS03425	COG1053	succinate dehydrogenase
I6J45_RS03430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J45_RS03455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J45_RS03475	COG2354	Protein conserved in bacteria
I6J45_RS03480	COG2321	neutral zinc metallopeptidase
I6J45_RS03500	COG2843	Capsule synthesis protein
I6J45_RS03520	COG0589	response to stress
I6J45_RS03530	COG0251	oxidation-reduction process
I6J45_RS03535	COG1309	transcriptional regulator
I6J45_RS03550	COG0505	Belongs to the CarA family
I6J45_RS03580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J45_RS03585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J45_RS03625	COG2264	protein methyltransferase activity
I6J45_RS03635	COG0477	Major facilitator Superfamily
I6J45_RS03640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J45_RS03655	COG1597	lipid kinase activity
I6J45_RS03660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J45_RS03685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J45_RS03690	COG0584	glycerophosphoryl diester phosphodiesterase
I6J45_RS03710	COG0741	lytic transglycosylase activity
I6J45_RS03730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J45_RS03765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J45_RS03770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J45_RS03775	COG0778	Nitroreductase
I6J45_RS03790	COG1929	Belongs to the glycerate kinase type-1 family
I6J45_RS03795	COG0243	molybdopterin cofactor binding
I6J45_RS03800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J45_RS03805	COG3339	Conserved Protein
I6J45_RS03830	COG1115	amino acid carrier protein
I6J45_RS03835	COG1113	amino acid transport
I6J45_RS03845	COG0019	diaminopimelate decarboxylase activity
I6J45_RS03855	COG1280	lysine exporter protein (LysE YggA)
I6J45_RS03860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J45_RS03890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J45_RS03920	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J45_RS03925	COG1136	(ABC) transporter
I6J45_RS03930	COG0658	competence protein
I6J45_RS03930	COG2333	competence protein COMEC
I6J45_RS03940	COG0616	signal peptide processing
I6J45_RS03940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J45_RS03945	COG0596	Alpha beta hydrolase
I6J45_RS03950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J45_RS03960	COG0628	permease
I6J45_RS03995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J45_RS04015	COG0823	Involved in the tonB-independent uptake of proteins
I6J45_RS04035	COG0824	Thioesterase
I6J45_RS04040	COG1473	amidohydrolase
I6J45_RS04060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J45_RS04060	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J45_RS04065	COG2814	Major facilitator Superfamily
I6J45_RS04070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J45_RS04075	COG1024	Enoyl-CoA hydratase
I6J45_RS04080	COG1051	belongs to the nudix hydrolase family
I6J45_RS04080	COG1056	cytidyltransferase-related domain
I6J45_RS04095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J45_RS04110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J45_RS04125	COG4625	pathogenesis
I6J45_RS04130	COG0583	DNA-binding transcription factor activity
I6J45_RS04135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J45_RS04140	COG4208	sulfate ABC transporter
I6J45_RS04145	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J45_RS04155	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6J45_RS04160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J45_RS04165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J45_RS04185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J45_RS04195	COG0481	GTPase activity
I6J45_RS04200	COG0681	Belongs to the peptidase S26 family
I6J45_RS04210	COG0571	ribonuclease III activity
I6J45_RS04215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J45_RS04230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J45_RS04240	COG4221	oxidoreductase activity
I6J45_RS04270	COG0436	Aminotransferase
I6J45_RS04290	COG0556	nucleotide-excision repair
I6J45_RS04300	COG2962	Rard protein
I6J45_RS04345	COG2070	2-Nitropropane dioxygenase
I6J45_RS04360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J45_RS04375	COG1215	transferase activity, transferring glycosyl groups
I6J45_RS04390	COG0415	Belongs to the DNA photolyase family
I6J45_RS04400	COG1252	NADH dehydrogenase
I6J45_RS04405	COG1686	Belongs to the peptidase S11 family
I6J45_RS04420	COG1187	pseudouridine synthase activity
I6J45_RS04435	COG0477	Major facilitator Superfamily
I6J45_RS04440	COG0583	DNA-binding transcription factor activity
I6J45_RS04445	COG1823	symporter activity
I6J45_RS04455	COG0612	Peptidase, M16
I6J45_RS04480	COG0352	thiamine-phosphate diphosphorylase activity
I6J45_RS04515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J45_RS04530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J45_RS04535	COG0076	glutamate decarboxylase activity
I6J45_RS04545	COG1522	sequence-specific DNA binding
I6J45_RS04550	COG3961	Belongs to the TPP enzyme family
I6J45_RS04555	COG1113	amino acid transport
I6J45_RS04560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J45_RS04565	COG0573	inorganic phosphate transmembrane transporter activity
I6J45_RS04575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J45_RS04580	COG0616	signal peptide processing
I6J45_RS04615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J45_RS04620	COG1686	Belongs to the peptidase S11 family
I6J45_RS04645	COG0583	DNA-binding transcription factor activity
I6J45_RS04650	COG1067	ATP-dependent peptidase activity
I6J45_RS04690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J45_RS04695	COG1966	Carbon starvation protein
I6J45_RS04700	COG2879	small protein
I6J45_RS04735	COG1741	Belongs to the pirin family
I6J45_RS04750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J45_RS04755	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J45_RS04760	COG4605	iron ion homeostasis
I6J45_RS04765	COG4604	ABC transporter, ATP-binding protein
I6J45_RS04770	COG4607	ABC-type enterochelin transport system periplasmic component
I6J45_RS04775	COG4774	siderophore transport
I6J45_RS04785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J45_RS04790	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J45_RS04795	COG1535	isochorismatase
I6J45_RS04795	COG3433	isochorismatase activity
I6J45_RS04805	COG1132	(ABC) transporter
I6J45_RS04810	COG1132	(ABC) transporter
I6J45_RS04815	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J45_RS04820	COG2977	Belongs to the P-Pant transferase superfamily
I6J45_RS04825	COG1169	isochorismate synthase
I6J45_RS04840	COG3739	integral membrane protein
I6J45_RS04860	COG0302	gtp cyclohydrolase
I6J45_RS04870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J45_RS04880	COG2840	Smr protein MutS2
I6J45_RS04915	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J45_RS04930	COG0174	glutamine synthetase
I6J45_RS04940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J45_RS04975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J45_RS04980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J45_RS04985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J45_RS05005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J45_RS05010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J45_RS05015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J45_RS05030	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS05035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J45_RS05040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J45_RS05050	COG2223	nitrite transmembrane transporter activity
I6J45_RS05060	COG0024	Methionine aminopeptidase
I6J45_RS05065	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J45_RS05105	COG2951	lytic endotransglycosylase activity
I6J45_RS05110	COG0772	Belongs to the SEDS family
I6J45_RS05125	COG0842	Transport permease protein
I6J45_RS05130	COG1131	(ABC) transporter
I6J45_RS05175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J45_RS05185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J45_RS05190	COG4215	(ABC) transporter
I6J45_RS05195	COG4160	amino acid transport
I6J45_RS05200	COG4598	ABC transporter
I6J45_RS05210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J45_RS05215	COG0826	peptidase U32
I6J45_RS05220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J45_RS05225	COG0384	phenazine biosynthesis protein PhzF
I6J45_RS05235	COG1720	tRNA m6t6A37 methyltransferase activity
I6J45_RS05245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J45_RS05260	COG0642	Histidine kinase
I6J45_RS05270	COG0494	nUDIX hydrolase
I6J45_RS05280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J45_RS05285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J45_RS05290	COG3139	Protein of unknown function (DUF1315)
I6J45_RS05295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J45_RS05300	COG1301	dicarboxylic acid transport
I6J45_RS05305	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS05320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J45_RS05330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J45_RS05335	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J45_RS05355	COG1690	Belongs to the RtcB family
I6J45_RS05360	COG1234	tRNA 3'-trailer cleavage
I6J45_RS05365	COG4650	regulator
I6J45_RS05395	COG2363	Small membrane protein
I6J45_RS05415	COG0513	Belongs to the DEAD box helicase family
I6J45_RS05425	COG0778	Nitroreductase
I6J45_RS05455	COG1286	toxin biosynthetic process
I6J45_RS05480	COG4783	chaperone-mediated protein folding
I6J45_RS05485	COG1610	YqeY-like protein
I6J45_RS05540	COG1278	Cold shock
I6J45_RS05555	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6J45_RS05560	COG0786	glutamate:sodium symporter activity
I6J45_RS05565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J45_RS05565	COG0475	glutathione-regulated potassium exporter activity
I6J45_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS05620	COG1309	transcriptional regulator
I6J45_RS05630	COG2985	domain, Protein
I6J45_RS05645	COG2995	paraquat-inducible protein a
I6J45_RS05650	COG3008	intermembrane lipid transfer
I6J45_RS05650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J45_RS05660	COG2351	hydroxyisourate hydrolase activity
I6J45_RS05700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J45_RS05710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J45_RS05715	COG0642	Histidine kinase
I6J45_RS05720	COG0745	RESPONSE REGULATOR receiver
I6J45_RS05735	COG1794	racemase activity, acting on amino acids and derivatives
I6J45_RS05765	COG1301	dicarboxylic acid transport
I6J45_RS05775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J45_RS05780	COG2011	ABC-type metal ion transport system permease component
I6J45_RS05785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J45_RS05795	COG0151	Belongs to the GarS family
I6J45_RS05805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6J45_RS05835	COG2308	Evidence 4 Homologs of previously reported genes of
I6J45_RS05845	COG1305	Transglutaminase-like
I6J45_RS05855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J45_RS05860	COG0305	Participates in initiation and elongation during chromosome replication
I6J45_RS05885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J45_RS05890	COG1845	cytochrome c oxidase, subunit III
I6J45_RS05895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J45_RS05925	COG1649	PFAM Uncharacterised BCR, COG1649
I6J45_RS05925	COG0726	polysaccharide deacetylase
I6J45_RS05930	COG1215	transferase activity, transferring glycosyl groups
I6J45_RS05935	COG3658	cytochrome
I6J45_RS05945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J45_RS05960	COG0583	DNA-binding transcription factor activity
I6J45_RS05975	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J45_RS05980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J45_RS05985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J45_RS06000	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS06005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J45_RS06020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J45_RS06030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J45_RS06035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J45_RS06045	COG2205	protein histidine kinase activity
I6J45_RS06050	COG0745	RESPONSE REGULATOR receiver
I6J45_RS06055	COG0174	glutamine synthetase
I6J45_RS06075	COG0729	surface antigen
I6J45_RS06105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J45_RS06110	COG2814	Major facilitator Superfamily
I6J45_RS06120	COG0583	DNA-binding transcription factor activity
I6J45_RS06135	COG1187	pseudouridine synthase activity
I6J45_RS06155	COG0802	atpase or kinase
I6J45_RS06160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J45_RS06170	COG1923	regulation of RNA biosynthetic process
I6J45_RS06175	COG0697	spore germination
I6J45_RS06200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J45_RS06205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J45_RS06205	COG0519	Catalyzes the synthesis of GMP from XMP
I6J45_RS06210	COG4302	ethanolamine ammonia-lyase activity
I6J45_RS06215	COG4303	Ethanolamine ammonia lyase large subunit
I6J45_RS06220	COG0531	amino acid
I6J45_RS06240	COG1454	alcohol dehydrogenase
I6J45_RS06245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J45_RS06270	COG0308	aminopeptidase N
I6J45_RS06310	COG1605	Chorismate mutase
I6J45_RS06325	COG4772	TonB-dependent receptor
I6J45_RS06380	COG3772	lysozyme
I6J45_RS06390	COG1733	regulation of RNA biosynthetic process
I6J45_RS06415	COG0583	DNA-binding transcription factor activity
I6J45_RS06450	COG0488	(ABC) transporter
I6J45_RS06455	COG0589	response to stress
I6J45_RS06475	COG3135	benzoate transporter
I6J45_RS06480	COG1522	sequence-specific DNA binding
I6J45_RS06490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J45_RS06495	COG0583	DNA-binding transcription factor activity
I6J45_RS06505	COG0183	Belongs to the thiolase family
I6J45_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS06515	COG2030	dehydratase
I6J45_RS06520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J45_RS06545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J45_RS06560	COG0824	Thioesterase
I6J45_RS06565	COG1454	alcohol dehydrogenase
I6J45_RS06580	COG1335	isochorismatase
I6J45_RS06595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J45_RS06625	COG0069	glutamate synthase activity
I6J45_RS06650	COG2814	Major facilitator Superfamily
I6J45_RS06665	COG0511	ligase activity, forming carbon-carbon bonds
I6J45_RS06690	COG4264	IucA IucC family
I6J45_RS06700	COG4264	IucA IucC family
I6J45_RS06705	COG2423	ornithine cyclodeaminase activity
I6J45_RS06710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J45_RS06720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J45_RS06720	COG1116	anion transmembrane transporter activity
I6J45_RS06735	COG2146	nitrite reductase [NAD(P)H] activity
I6J45_RS06735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J45_RS06740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J45_RS06745	COG0243	molybdopterin cofactor binding
I6J45_RS06755	COG0243	molybdopterin cofactor binding
I6J45_RS06760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J45_RS06775	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J45_RS06775	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J45_RS06780	COG0303	'Molybdopterin
I6J45_RS06790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J45_RS06795	COG0697	spore germination
I6J45_RS06820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J45_RS06890	COG2204	response regulator
I6J45_RS06895	COG3852	Histidine kinase
I6J45_RS06920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J45_RS06925	COG0575	Belongs to the CDS family
I6J45_RS06960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J45_RS06975	COG2137	regulation of response to DNA damage stimulus
I6J45_RS06985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J45_RS06990	COG1011	Hydrolase
I6J45_RS07005	COG1522	sequence-specific DNA binding
I6J45_RS07015	COG1113	amino acid transport
I6J45_RS07020	COG0657	acetylesterase activity
I6J45_RS07035	COG0659	secondary active sulfate transmembrane transporter activity
I6J45_RS07070	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J45_RS07070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J45_RS07070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J45_RS07075	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J45_RS07080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J45_RS07080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J45_RS07100	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6J45_RS07110	COG0024	Methionine aminopeptidase
I6J45_RS07115	COG0583	DNA-binding transcription factor activity
I6J45_RS07125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6J45_RS07130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J45_RS07135	COG0517	IMP dehydrogenase activity
I6J45_RS07135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J45_RS07160	COG0552	protein localization to endoplasmic reticulum
I6J45_RS07185	COG4890	Cyd operon protein YbgT
I6J45_RS07190	COG1294	oxidase, subunit
I6J45_RS07205	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J45_RS07215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J45_RS07230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J45_RS07235	COG0569	domain protein
I6J45_RS07240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J45_RS07270	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J45_RS07275	COG0542	response to heat
I6J45_RS07285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J45_RS07300	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J45_RS07300	COG1902	pentaerythritol trinitrate reductase activity
I6J45_RS07340	COG0148	phosphopyruvate hydratase activity
I6J45_RS07345	COG2323	membrane
I6J45_RS07355	COG4773	Receptor
I6J45_RS07360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6J45_RS07370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J45_RS07375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J45_RS07380	COG0183	Belongs to the thiolase family
I6J45_RS07385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J45_RS07390	COG0596	Alpha beta hydrolase
I6J45_RS07395	COG2271	Major facilitator Superfamily
I6J45_RS07400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J45_RS07405	COG3485	protocatechuate 3,4-dioxygenase
I6J45_RS07410	COG3485	protocatechuate 3,4-dioxygenase
I6J45_RS07415	COG0710	3-dehydroquinate dehydratase activity
I6J45_RS07420	COG3420	alginic acid biosynthetic process
I6J45_RS07425	COG3659	wide pore channel activity
I6J45_RS07430	COG4993	Dehydrogenase
I6J45_RS07440	COG2391	methyltransferase activity
I6J45_RS07455	COG1414	Transcriptional regulator
I6J45_RS07460	COG0583	DNA-binding transcription factor activity
I6J45_RS07465	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS07490	COG2814	Major facilitator Superfamily
I6J45_RS07500	COG0154	amidase activity
I6J45_RS07520	COG4638	Rieske (2fe-2S)
I6J45_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS07540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J45_RS07550	COG3733	amine oxidase
I6J45_RS07560	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS07565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J45_RS07570	COG0183	Belongs to the thiolase family
I6J45_RS07575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J45_RS07580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J45_RS07590	COG4829	muconolactone delta-isomerase
I6J45_RS07595	COG4948	Mandelate Racemase Muconate Lactonizing
I6J45_RS07600	COG0583	DNA-binding transcription factor activity
I6J45_RS07610	COG2186	Transcriptional regulator
I6J45_RS07630	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS07635	COG2351	hydroxyisourate hydrolase activity
I6J45_RS07640	COG2233	PERMEase
I6J45_RS07650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J45_RS07655	COG2186	Transcriptional regulator
I6J45_RS07665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J45_RS07675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J45_RS07695	COG1902	pentaerythritol trinitrate reductase activity
I6J45_RS07695	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J45_RS07735	COG1309	transcriptional regulator
I6J45_RS07740	COG0583	DNA-binding transcription factor activity
I6J45_RS07745	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS07750	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS07765	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS07775	COG0318	PFAM AMP-dependent synthetase and ligase
I6J45_RS07785	COG1309	transcriptional regulator
I6J45_RS07850	COG0583	DNA-binding transcription factor activity
I6J45_RS07875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J45_RS07880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J45_RS07895	COG2831	hemolysin activation secretion protein
I6J45_RS07900	COG3210	domain, Protein
I6J45_RS07955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J45_RS07960	COG1120	ATPase activity
I6J45_RS07970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J45_RS08020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J45_RS08070	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6J45_RS08080	COG4628	conserved protein (DUF2132)
I6J45_RS08090	COG3539	Fimbrial protein
I6J45_RS08115	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J45_RS08125	COG0753	catalase activity
I6J45_RS08145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J45_RS08155	COG2205	protein histidine kinase activity
I6J45_RS08160	COG0745	RESPONSE REGULATOR receiver
I6J45_RS08165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J45_RS08170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J45_RS08225	COG3433	isochorismatase activity
I6J45_RS08225	COG1535	isochorismatase
I6J45_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS08235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J45_RS08240	COG4149	molybdate abc transporter
I6J45_RS08245	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J45_RS08255	COG4638	Rieske (2fe-2S)
I6J45_RS08260	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J45_RS08265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J45_RS08265	COG0543	2 iron, 2 sulfur cluster binding
I6J45_RS08280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J45_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS08310	COG2207	Transcriptional regulator
I6J45_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS08320	COG2610	gluconate transmembrane transporter activity
I6J45_RS08360	COG0583	DNA-binding transcription factor activity
I6J45_RS08375	COG2031	fatty acid transporter
I6J45_RS08380	COG0183	Belongs to the thiolase family
I6J45_RS08385	COG0583	DNA-binding transcription factor activity
I6J45_RS08390	COG0583	DNA-binding transcription factor activity
I6J45_RS08405	COG1027	Aspartate ammonia-lyase
I6J45_RS08415	COG0477	Major facilitator Superfamily
I6J45_RS08425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J45_RS08430	COG1733	regulation of RNA biosynthetic process
I6J45_RS08435	COG2207	Transcriptional regulator
I6J45_RS08435	COG3708	Transcriptional regulator
I6J45_RS08450	COG0730	response to heat
I6J45_RS08470	COG3781	membrane
I6J45_RS08475	COG1063	alcohol dehydrogenase
I6J45_RS08485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J45_RS08490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J45_RS08495	COG0022	dehydrogenase e1 component
I6J45_RS08500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J45_RS08505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J45_RS08520	COG3706	GGDEF domain
I6J45_RS08540	COG0133	tryptophan synthase activity
I6J45_RS08550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J45_RS08580	COG0583	DNA-binding transcription factor activity
I6J45_RS08585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J45_RS08595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J45_RS08655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J45_RS08660	COG4773	Receptor
I6J45_RS08685	COG0730	response to heat
I6J45_RS08690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J45_RS08710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J45_RS08725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J45_RS08735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J45_RS08750	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS08755	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS08760	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J45_RS08765	COG2207	Transcriptional regulator
I6J45_RS08770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J45_RS08775	COG0776	regulation of translation
I6J45_RS08800	COG0822	iron-sulfur transferase activity
I6J45_RS08805	COG0316	Belongs to the HesB IscA family
I6J45_RS08835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J45_RS08855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J45_RS08860	COG0702	epimerase
I6J45_RS08900	COG0601	transmembrane transport
I6J45_RS08905	COG0339	signal peptide processing
I6J45_RS08910	COG4166	transmembrane transport
I6J45_RS08955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J45_RS08960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J45_RS08975	COG2431	L-lysine efflux transmembrane transporter activity
I6J45_RS08990	COG0776	regulation of translation
I6J45_RS09055	COG0084	hydrolase, TatD family'
I6J45_RS09075	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J45_RS09080	COG1132	(ABC) transporter
I6J45_RS09090	COG0811	peptide transport
I6J45_RS09095	COG1475	DNA binding
I6J45_RS09100	COG1192	Involved in chromosome partitioning
I6J45_RS09110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J45_RS09115	COG3178	'Phosphotransferase
I6J45_RS09125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J45_RS09150	COG0424	maF-like protein
I6J45_RS09155	COG2850	peptidyl-arginine hydroxylation
I6J45_RS09165	COG0640	Transcriptional regulator
I6J45_RS09175	COG3619	membrane
I6J45_RS09180	COG3122	Protein conserved in bacteria
I6J45_RS09185	COG1132	(ABC) transporter
I6J45_RS09205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J45_RS09210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J45_RS09220	COG0506	proline dehydrogenase activity
I6J45_RS09220	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J45_RS09220	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J45_RS09225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J45_RS09240	COG3698	Phosphodiester glycosidase
I6J45_RS09250	COG2353	YceI-like domain
I6J45_RS09260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J45_RS09305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J45_RS09305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J45_RS09330	COG3539	Fimbrial protein
I6J45_RS09365	COG0583	DNA-binding transcription factor activity
I6J45_RS09370	COG0697	spore germination
I6J45_RS09380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J45_RS09390	COG0583	DNA-binding transcription factor activity
I6J45_RS09405	COG1309	transcriptional regulator
I6J45_RS09420	COG1522	sequence-specific DNA binding
I6J45_RS09430	COG1126	abc transporter atp-binding protein
I6J45_RS09435	COG0765	amino acid transport
I6J45_RS09440	COG0765	amino acid transport
I6J45_RS09470	COG1464	Belongs to the NlpA lipoprotein family
I6J45_RS09480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J45_RS09485	COG2011	ABC-type metal ion transport system permease component
I6J45_RS09490	COG0012	GTP binding
I6J45_RS09515	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J45_RS09550	COG2207	Transcriptional regulator
I6J45_RS09550	COG1917	Cupin 2, conserved barrel domain protein
I6J45_RS09555	COG0386	Belongs to the glutathione peroxidase family
I6J45_RS09565	COG0436	Aminotransferase
I6J45_RS09570	COG1301	dicarboxylic acid transport
I6J45_RS09605	COG3634	alkyl hydroperoxide reductase activity
I6J45_RS09620	COG0583	DNA-binding transcription factor activity
I6J45_RS09625	COG0431	NADPH-dependent FMN reductase
I6J45_RS09630	COG0798	PFAM Bile acid sodium symporter
I6J45_RS09640	COG0640	Transcriptional regulator
I6J45_RS09655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J45_RS09665	COG0583	DNA-binding transcription factor activity
I6J45_RS09675	COG1953	Uracil, thiamine, allantoin
I6J45_RS09685	COG2175	clavaminate synthase activity
I6J45_RS09690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J45_RS09695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J45_RS09700	COG4521	taurine ABC transporter
I6J45_RS09710	COG0477	Major facilitator Superfamily
I6J45_RS09730	COG1271	oxidase subunit
I6J45_RS09735	COG1294	oxidase, subunit
I6J45_RS09745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J45_RS09765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J45_RS09785	COG3052	prosthetic group binding
I6J45_RS09790	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6J45_RS09815	COG1346	cytolysis
I6J45_RS09825	COG0583	DNA-binding transcription factor activity
I6J45_RS09830	COG0625	glutathione transferase activity
I6J45_RS09835	COG0625	glutathione transferase activity
I6J45_RS09855	COG0583	DNA-binding transcription factor activity
I6J45_RS09870	COG1045	serine acetyltransferase
I6J45_RS09875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J45_RS09880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J45_RS09885	COG1280	lysine exporter protein (LysE YggA)
I6J45_RS09900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J45_RS09905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J45_RS09915	COG0765	amino acid transport
I6J45_RS09920	COG0765	amino acid transport
I6J45_RS09940	COG0784	Response regulator, receiver
I6J45_RS09940	COG2205	protein histidine kinase activity
I6J45_RS09960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J45_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS10025	COG0583	DNA-binding transcription factor activity
I6J45_RS10035	COG2814	Major facilitator Superfamily
I6J45_RS10050	COG0318	PFAM AMP-dependent synthetase and ligase
I6J45_RS10055	COG1309	transcriptional regulator
I6J45_RS10060	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS10065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J45_RS10070	COG1024	Enoyl-CoA hydratase
I6J45_RS10075	COG4770	biotin carboxylase activity
I6J45_RS10085	COG0583	DNA-binding transcription factor activity
I6J45_RS10100	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS10110	COG2814	Major facilitator Superfamily
I6J45_RS10120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J45_RS10125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J45_RS10130	COG2814	Major facilitator Superfamily
I6J45_RS10135	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS10140	COG1024	Enoyl-CoA hydratase
I6J45_RS10145	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS10150	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J45_RS10155	COG0183	Belongs to the thiolase family
I6J45_RS10165	COG2814	Major facilitator Superfamily
I6J45_RS10175	COG1024	Enoyl-CoA hydratase
I6J45_RS10190	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS10195	COG2814	Major facilitator Superfamily
I6J45_RS10200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J45_RS10205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J45_RS10220	COG3842	ATPase activity
I6J45_RS10225	COG1840	ABC-type Fe3 transport system, periplasmic component
I6J45_RS10240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J45_RS10245	COG1414	Transcriptional regulator
I6J45_RS10255	COG0583	DNA-binding transcription factor activity
I6J45_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS10285	COG0583	DNA-binding transcription factor activity
I6J45_RS10290	COG2050	protein possibly involved in aromatic compounds catabolism
I6J45_RS10300	COG3327	negative regulation of DNA-templated transcription, initiation
I6J45_RS10305	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J45_RS10310	COG0183	Belongs to the thiolase family
I6J45_RS10315	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J45_RS10320	COG1024	Enoyl-CoA hydratase
I6J45_RS10325	COG1024	Enoyl-CoA hydratase
I6J45_RS10330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J45_RS10335	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J45_RS10340	COG3396	Phenylacetate-CoA oxygenase
I6J45_RS10345	COG3460	Phenylacetate-CoA oxygenase
I6J45_RS10350	COG3396	Phenylacetate-CoA oxygenase
I6J45_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS10355	COG2030	dehydratase
I6J45_RS10360	COG1760	l-serine dehydratase
I6J45_RS10375	COG0789	Transcriptional regulator
I6J45_RS10385	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J45_RS10390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J45_RS10405	COG2807	transmembrane transport
I6J45_RS10410	COG0590	tRNA wobble adenosine to inosine editing
I6J45_RS10415	COG0666	response to abiotic stimulus
I6J45_RS10460	COG1063	alcohol dehydrogenase
I6J45_RS10465	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J45_RS10495	COG3210	domain, Protein
I6J45_RS10500	COG2831	hemolysin activation secretion protein
I6J45_RS10505	COG0038	chloride channel
I6J45_RS10510	COG4770	biotin carboxylase activity
I6J45_RS10530	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J45_RS10535	COG0583	DNA-binding transcription factor activity
I6J45_RS10545	COG1595	DNA-templated transcription, initiation
I6J45_RS10555	COG3220	belongs to the UPF0276 family
I6J45_RS10610	COG0702	epimerase
I6J45_RS10615	COG1733	regulation of RNA biosynthetic process
I6J45_RS10630	COG1051	belongs to the nudix hydrolase family
I6J45_RS10640	COG1595	DNA-templated transcription, initiation
I6J45_RS10645	COG3712	iron ion homeostasis
I6J45_RS10690	COG3038	cytochrome b561
I6J45_RS10695	COG0753	catalase activity
I6J45_RS10700	COG1733	regulation of RNA biosynthetic process
I6J45_RS10725	COG1522	sequence-specific DNA binding
I6J45_RS10730	COG0531	amino acid
I6J45_RS10735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J45_RS10750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J45_RS10765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J45_RS10775	COG4122	O-methyltransferase activity
I6J45_RS10805	COG1538	Outer membrane efflux protein
I6J45_RS10810	COG1137	ATPase activity
I6J45_RS10815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J45_RS10825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J45_RS10865	COG2814	Major facilitator Superfamily
I6J45_RS10875	COG0668	transmembrane transport
I6J45_RS10920	COG1309	transcriptional regulator
I6J45_RS10930	COG2226	methyltransferase
I6J45_RS10955	COG1278	Cold shock
I6J45_RS10960	COG1560	Kdo2-lipid A biosynthetic process
I6J45_RS10965	COG1280	lysine exporter protein (LysE YggA)
I6J45_RS11000	COG1570	exodeoxyribonuclease VII activity
I6J45_RS11085	COG2871	sodium ion transport
I6J45_RS11095	COG0583	DNA-binding transcription factor activity
I6J45_RS11105	COG4638	Rieske (2fe-2S)
I6J45_RS11110	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J45_RS11115	COG0543	2 iron, 2 sulfur cluster binding
I6J45_RS11115	COG0633	Ferredoxin
I6J45_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS11125	COG3135	benzoate transporter
I6J45_RS11130	COG2814	Major facilitator Superfamily
I6J45_RS11145	COG1643	Atp-dependent helicase
I6J45_RS11170	COG3634	alkyl hydroperoxide reductase activity
I6J45_RS11190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J45_RS11210	COG0625	glutathione transferase activity
I6J45_RS11220	COG2885	chlorophyll binding
I6J45_RS11255	COG0542	response to heat
I6J45_RS11270	COG1765	OsmC-like protein
I6J45_RS11285	COG0667	Aldo Keto reductase
I6J45_RS11300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J45_RS11310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J45_RS11320	COG0527	aspartate kinase activity
I6J45_RS11330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J45_RS11340	COG3038	cytochrome b561
I6J45_RS11345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J45_RS11350	COG2252	PERMEase
I6J45_RS11360	COG1741	Belongs to the pirin family
I6J45_RS11365	COG1309	transcriptional regulator
I6J45_RS11380	COG2072	flavoprotein involved in K transport
I6J45_RS11385	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J45_RS11390	COG0583	DNA-binding transcription factor activity
I6J45_RS11405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J45_RS11435	COG1944	ATP diphosphatase activity
I6J45_RS11455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J45_RS11470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J45_RS11490	COG2814	Major facilitator Superfamily
I6J45_RS11495	COG1024	Enoyl-CoA hydratase
I6J45_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS11510	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS11535	COG2186	Transcriptional regulator
I6J45_RS11540	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS11550	COG4948	Mandelate Racemase Muconate Lactonizing
I6J45_RS11555	COG2271	Major facilitator Superfamily
I6J45_RS11560	COG2721	sulfolactate sulfo-lyase activity
I6J45_RS11565	COG0697	spore germination
I6J45_RS11585	COG3210	domain, Protein
I6J45_RS11590	COG2831	hemolysin activation secretion protein
I6J45_RS11595	COG1113	amino acid transport
I6J45_RS11615	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS11635	COG0531	amino acid
I6J45_RS11645	COG1113	amino acid transport
I6J45_RS11680	COG4269	membrane
I6J45_RS11700	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J45_RS11700	COG1902	pentaerythritol trinitrate reductase activity
I6J45_RS11710	COG5001	Diguanylate cyclase
I6J45_RS11710	COG4251	negative regulation of phosphorylation
I6J45_RS11710	COG3706	GGDEF domain
I6J45_RS11710	COG2203	Gaf domain
I6J45_RS11720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J45_RS11745	COG4172	Belongs to the ABC transporter superfamily
I6J45_RS11750	COG4239	(ABC) transporter, permease
I6J45_RS11755	COG4174	ABC transporter (Permease)
I6J45_RS11760	COG4166	transmembrane transport
I6J45_RS11765	COG1388	LysM domain
I6J45_RS11765	COG0741	lytic transglycosylase activity
I6J45_RS11765	COG1388	LysM domain
I6J45_RS11765	COG0741	lytic transglycosylase activity
I6J45_RS11810	COG0583	DNA-binding transcription factor activity
I6J45_RS11815	COG1279	arginine transmembrane transporter activity
I6J45_RS11825	COG0789	Transcriptional regulator
I6J45_RS11835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J45_RS11840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J45_RS11845	COG0006	proline dipeptidase activity
I6J45_RS11885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J45_RS11900	COG3384	dioxygenase
I6J45_RS11910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J45_RS11915	COG2878	Part of a membrane complex involved in electron transport
I6J45_RS11920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J45_RS11945	COG0768	penicillin binding
I6J45_RS11950	COG0742	ribosomal rna small subunit methyltransferase
I6J45_RS11965	COG0830	nickel cation binding
I6J45_RS11975	COG0804	urea catabolic process
I6J45_RS12000	COG3015	lipoprotein NlpE involved in copper resistance
I6J45_RS12015	COG1253	flavin adenine dinucleotide binding
I6J45_RS12020	COG2851	Citrate transporter
I6J45_RS12070	COG1773	rubredoxin
I6J45_RS12075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J45_RS12080	COG2267	carboxylic ester hydrolase activity
I6J45_RS12085	COG0583	DNA-binding transcription factor activity
I6J45_RS12115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J45_RS12120	COG4181	ATPase activity
I6J45_RS12165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J45_RS12185	COG0306	phosphate transporter
I6J45_RS12210	COG2223	nitrite transmembrane transporter activity
I6J45_RS12215	COG2207	Transcriptional regulator
I6J45_RS12220	COG2066	Belongs to the glutaminase family
I6J45_RS12225	COG0242	peptide deformylase activity
I6J45_RS12230	COG0477	Major facilitator Superfamily
I6J45_RS12240	COG0028	Belongs to the TPP enzyme family
I6J45_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS12260	COG2267	carboxylic ester hydrolase activity
I6J45_RS12270	COG2271	Major facilitator Superfamily
I6J45_RS12275	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J45_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS12305	COG1414	Transcriptional regulator
I6J45_RS12320	COG1024	Enoyl-CoA hydratase
I6J45_RS12330	COG1215	transferase activity, transferring glycosyl groups
I6J45_RS12335	COG1649	PFAM Uncharacterised BCR, COG1649
I6J45_RS12335	COG0726	polysaccharide deacetylase
I6J45_RS12345	COG4681	YaeQ
I6J45_RS12355	COG0523	cobalamin synthesis protein
I6J45_RS12365	COG1607	acyl-coa hydrolase
I6J45_RS12375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J45_RS12380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J45_RS12385	COG1309	transcriptional regulator
I6J45_RS12410	COG2040	homocysteine
I6J45_RS12415	COG0531	amino acid
I6J45_RS12465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J45_RS12470	COG2814	Major facilitator Superfamily
I6J45_RS12480	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J45_RS12525	COG1401	restriction endodeoxyribonuclease activity
I6J45_RS12535	COG0405	Gamma-glutamyltransferase
I6J45_RS12540	COG2814	Major facilitator Superfamily
I6J45_RS12550	COG2050	protein possibly involved in aromatic compounds catabolism
I6J45_RS12565	COG1090	epimerase
I6J45_RS12585	COG0420	3'-5' exonuclease activity
I6J45_RS12610	COG0735	belongs to the Fur family
I6J45_RS12615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J45_RS12620	COG2914	Belongs to the UPF0125 (RnfH) family
I6J45_RS12635	COG0121	glutamine amidotransferase
I6J45_RS12650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J45_RS12660	COG0210	DNA helicase
I6J45_RS12665	COG2885	chlorophyll binding
I6J45_RS12670	COG0204	Acyl-transferase
I6J45_RS12685	COG2894	cell division
I6J45_RS12700	COG1280	lysine exporter protein (LysE YggA)
I6J45_RS12705	COG1674	ftsk spoiiie
I6J45_RS12710	COG0492	ferredoxin-NADP+ reductase activity
I6J45_RS12715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6J45_RS12725	COG0456	acetyltransferase
I6J45_RS12740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J45_RS12745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J45_RS12755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J45_RS12770	COG1981	membrane
I6J45_RS12780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J45_RS12780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J45_RS12800	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS12805	COG4638	Rieske (2fe-2S)
I6J45_RS12810	COG0657	acetylesterase activity
I6J45_RS12820	COG0473	3-isopropylmalate dehydrogenase activity
I6J45_RS12825	COG0583	DNA-binding transcription factor activity
I6J45_RS12845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J45_RS12880	COG0358	DNA primase activity
I6J45_RS12895	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6J45_RS12925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J45_RS12955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J45_RS12965	COG0351	phosphomethylpyrimidine kinase
I6J45_RS12965	COG0352	thiamine-phosphate diphosphorylase activity
I6J45_RS12965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J45_RS12970	COG1652	LysM domain
I6J45_RS12995	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J45_RS13000	COG3101	peptidyl-lysine hydroxylation
I6J45_RS13005	COG0009	L-threonylcarbamoyladenylate synthase
I6J45_RS13010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J45_RS13015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J45_RS13030	COG4106	trans-aconitate 2-methyltransferase activity
I6J45_RS13045	COG2226	methyltransferase
I6J45_RS13045	COG0596	Alpha beta hydrolase
I6J45_RS13045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J45_RS13055	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J45_RS13060	COG2223	nitrite transmembrane transporter activity
I6J45_RS13080	COG1196	nuclear chromosome segregation
I6J45_RS13090	COG0730	response to heat
I6J45_RS13105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J45_RS13115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J45_RS13165	COG0489	protein tyrosine kinase activity
I6J45_RS13175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J45_RS13175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J45_RS13210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J45_RS13215	COG2081	HI0933 family
I6J45_RS13225	COG0668	transmembrane transport
I6J45_RS13245	COG0583	DNA-binding transcription factor activity
I6J45_RS13265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J45_RS13270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J45_RS13300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J45_RS13325	COG2199	diguanylate cyclase activity
I6J45_RS13340	COG0745	RESPONSE REGULATOR receiver
I6J45_RS13355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J45_RS13395	COG0110	maltose O-acetyltransferase activity
I6J45_RS13400	COG0438	transferase activity, transferring glycosyl groups
I6J45_RS13455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J45_RS13470	COG0583	DNA-binding transcription factor activity
I6J45_RS13525	COG0583	DNA-binding transcription factor activity
I6J45_RS13540	COG0583	DNA-binding transcription factor activity
I6J45_RS13545	COG1053	succinate dehydrogenase
I6J45_RS13560	COG1309	transcriptional regulator
I6J45_RS13570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J45_RS13575	COG2814	Major facilitator Superfamily
I6J45_RS13580	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS13585	COG0583	DNA-binding transcription factor activity
I6J45_RS13590	COG1063	alcohol dehydrogenase
I6J45_RS13620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J45_RS13625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J45_RS13630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J45_RS13650	COG2132	Multicopper oxidase
I6J45_RS13660	COG0561	phosphatase activity
I6J45_RS13665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J45_RS13675	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J45_RS13690	COG1214	PFAM Peptidase M22, glycoprotease
I6J45_RS13750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J45_RS13755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J45_RS13760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J45_RS13820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J45_RS13830	COG1846	Transcriptional regulator
I6J45_RS13835	COG1764	response to oxidative stress
I6J45_RS13875	COG0037	tRNA processing
I6J45_RS13885	COG0248	Ppx GppA phosphatase
I6J45_RS13915	COG0072	phenylalanine-tRNA ligase activity
I6J45_RS13940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J45_RS13955	COG1238	metal cluster binding
I6J45_RS13960	COG0625	glutathione transferase activity
I6J45_RS13975	COG0318	PFAM AMP-dependent synthetase and ligase
I6J45_RS13980	COG3028	Belongs to the UPF0307 family
I6J45_RS13985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J45_RS14005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J45_RS14010	COG0617	tRNA 3'-terminal CCA addition
I6J45_RS14015	COG1555	photosystem II stabilization
I6J45_RS14020	COG3956	TIGRFAM MazG family protein
I6J45_RS14025	COG4221	oxidoreductase activity
I6J45_RS14030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J45_RS14045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J45_RS14050	COG5002	protein histidine kinase activity
I6J45_RS14050	COG2205	protein histidine kinase activity
I6J45_RS14050	COG0784	Response regulator, receiver
I6J45_RS14055	COG1024	Enoyl-CoA hydratase
I6J45_RS14060	COG2084	Dehydrogenase
I6J45_RS14065	COG3622	Belongs to the hyi family
I6J45_RS14095	COG0697	spore germination
I6J45_RS14105	COG2814	Major facilitator Superfamily
I6J45_RS14140	COG2072	flavoprotein involved in K transport
I6J45_RS14145	COG0492	ferredoxin-NADP+ reductase activity
I6J45_RS14150	COG0431	NADPH-dependent FMN reductase
I6J45_RS14155	COG0798	PFAM Bile acid sodium symporter
I6J45_RS14165	COG0640	Transcriptional regulator
I6J45_RS14200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J45_RS14225	COG2132	Multicopper oxidase
I6J45_RS14240	COG2205	protein histidine kinase activity
I6J45_RS14325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J45_RS14340	COG0583	DNA-binding transcription factor activity
I6J45_RS14350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J45_RS14360	COG0084	hydrolase, TatD family'
I6J45_RS14375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J45_RS14395	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J45_RS14400	COG0440	acetolactate synthase activity
I6J45_RS14405	COG0028	Belongs to the TPP enzyme family
I6J45_RS14425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J45_RS14430	COG0577	efflux transmembrane transporter activity
I6J45_RS14430	COG1136	(ABC) transporter
I6J45_RS14460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J45_RS14465	COG1162	GTPase activity
I6J45_RS14475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J45_RS14495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J45_RS14515	COG1426	Protein conserved in bacteria
I6J45_RS14550	COG0793	Belongs to the peptidase S41A family
I6J45_RS14565	COG2267	carboxylic ester hydrolase activity
I6J45_RS14575	COG1012	belongs to the aldehyde dehydrogenase family
I6J45_RS14580	COG3265	gluconokinase activity
I6J45_RS14590	COG0800	Aldolase
I6J45_RS14605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J45_RS14610	COG0280	phosphate acetyltransferase
I6J45_RS14610	COG0857	belongs to the CobB CobQ family
I6J45_RS14615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J45_RS14615	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J45_RS14635	COG0740	serine-type endopeptidase activity
I6J45_RS14645	COG4774	siderophore transport
I6J45_RS14655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J45_RS14665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J45_RS14665	COG2813	Specifically methylates the guanine in position
I6J45_RS14765	COG0788	formyltetrahydrofolate deformylase activity
I6J45_RS14790	COG4651	solute:proton antiporter activity
I6J45_RS14790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J45_RS14810	COG0724	RNA recognition motif
I6J45_RS14815	COG0210	DNA helicase
I6J45_RS14840	COG1733	regulation of RNA biosynthetic process
I6J45_RS14845	COG0604	alcohol dehydrogenase
I6J45_RS14850	COG2900	Belongs to the SlyX family
I6J45_RS14855	COG0488	(ABC) transporter
I6J45_RS14865	COG1560	Kdo2-lipid A biosynthetic process
I6J45_RS14875	COG1301	dicarboxylic acid transport
I6J45_RS14930	COG0473	3-isopropylmalate dehydrogenase activity
I6J45_RS14955	COG0583	DNA-binding transcription factor activity
I6J45_RS15000	COG0583	DNA-binding transcription factor activity
I6J45_RS15010	COG0625	glutathione transferase activity
I6J45_RS15015	COG2378	regulation of single-species biofilm formation
I6J45_RS15020	COG0546	phosphoglycolate phosphatase activity
I6J45_RS15030	COG1530	ribonuclease E activity
I6J45_RS15035	COG0318	PFAM AMP-dependent synthetase and ligase
I6J45_RS15050	COG0583	DNA-binding transcription factor activity
I6J45_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS15060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J45_RS15070	COG0534	Mate efflux family protein
I6J45_RS15085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J45_RS15110	COG0493	'glutamate synthase
I6J45_RS15120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6J45_RS15125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J45_RS15140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J45_RS15150	COG0644	oxidoreductase
I6J45_RS15150	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J45_RS15165	COG4535	Mg2 and Co2 transporter CorC
I6J45_RS15175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J45_RS15195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J45_RS15205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J45_RS15215	COG0484	heat shock protein binding
I6J45_RS15220	COG0789	Transcriptional regulator
I6J45_RS15225	COG0598	Magnesium transport protein CorA
I6J45_RS15230	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J45_RS15240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J45_RS15245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J45_RS15250	COG1074	ATP-dependent DNA helicase activity
I6J45_RS15255	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J45_RS15275	COG2226	methyltransferase
I6J45_RS15285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J45_RS15290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J45_RS15300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J45_RS15315	COG2111	Na H antiporter
I6J45_RS15315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J45_RS15320	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J45_RS15325	COG0651	ATP synthesis coupled electron transport
I6J45_RS15330	COG1863	multisubunit Na H antiporter MnhE subunit
I6J45_RS15335	COG2212	antiporter activity
I6J45_RS15340	COG1320	monovalent cation:proton antiporter activity
I6J45_RS15345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J45_RS15355	COG0195	Participates in both transcription termination and antitermination
I6J45_RS15405	COG0237	dephospho-CoA kinase activity
I6J45_RS15415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J45_RS15430	COG0497	DNA recombination
I6J45_RS15440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J45_RS15475	COG2169	Transcriptional regulator
I6J45_RS15475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J45_RS15480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J45_RS15545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J45_RS15560	COG0326	Molecular chaperone. Has ATPase activity
I6J45_RS15575	COG2056	Na+-H+ antiporter family
I6J45_RS15645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J45_RS15675	COG0546	phosphoglycolate phosphatase activity
I6J45_RS15680	COG1716	ATPase activity
I6J45_RS15725	COG0181	hydroxymethylbilane synthase activity
I6J45_RS15735	COG3275	phosphorelay sensor kinase activity
I6J45_RS15755	COG1538	Outer membrane efflux protein
I6J45_RS15765	COG0697	spore germination
I6J45_RS15785	COG0494	nUDIX hydrolase
I6J45_RS15790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J45_RS15795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J45_RS15800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J45_RS15805	COG0772	Belongs to the SEDS family
I6J45_RS15830	COG4974	Belongs to the 'phage' integrase family
I6J45_RS15835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J45_RS15845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J45_RS15855	COG2197	response regulator
I6J45_RS15870	COG0793	Belongs to the peptidase S41A family
I6J45_RS15875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J45_RS15880	COG0795	lipopolysaccharide-transporting ATPase activity
I6J45_RS15920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J45_RS15920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J45_RS15930	COG0004	ammonium transporteR
I6J45_RS15935	COG0347	Belongs to the P(II) protein family
I6J45_RS15945	COG0606	chelatase, subunit chli
I6J45_RS15950	COG0431	NADPH-dependent FMN reductase
I6J45_RS15955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J45_RS15960	COG0235	Class ii aldolase
I6J45_RS15965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J45_RS15985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J45_RS16000	COG0318	PFAM AMP-dependent synthetase and ligase
I6J45_RS16010	COG0477	Major facilitator Superfamily
I6J45_RS16015	COG2860	membrane
I6J45_RS16025	COG1253	flavin adenine dinucleotide binding
I6J45_RS16035	COG2814	Major facilitator Superfamily
I6J45_RS16045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J45_RS16080	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J45_RS16095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J45_RS16125	COG1309	transcriptional regulator
I6J45_RS16160	COG0758	DNA mediated transformation
I6J45_RS16170	COG0697	spore germination
I6J45_RS16175	COG1309	transcriptional regulator
I6J45_RS16190	COG0386	Belongs to the glutathione peroxidase family
I6J45_RS16205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J45_RS16215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J45_RS16255	COG1121	(ABC) transporter
I6J45_RS16260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J45_RS16265	COG1280	lysine exporter protein (LysE YggA)
I6J45_RS16270	COG2837	iron assimilation
I6J45_RS16275	COG0281	malic enzyme
I6J45_RS16320	COG0519	Catalyzes the synthesis of GMP from XMP
I6J45_RS16320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J45_RS16325	COG4399	Belongs to the UPF0754 family
I6J45_RS16330	COG2259	Doxx family
I6J45_RS16335	COG0586	Pfam SNARE associated Golgi protein
I6J45_RS16350	COG1192	Involved in chromosome partitioning
I6J45_RS16360	COG0271	Belongs to the BolA IbaG family
I6J45_RS16400	COG3321	synthase
I6J45_RS16400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J45_RS16400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J45_RS16400	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J45_RS16405	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS16410	COG0318	PFAM AMP-dependent synthetase and ligase
I6J45_RS16415	COG2197	response regulator
I6J45_RS16425	COG3916	Acyl-homoserine-lactone synthase
I6J45_RS16430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J45_RS16440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J45_RS16445	COG1113	amino acid transport
I6J45_RS16450	COG0697	spore germination
I6J45_RS16455	COG0477	Major facilitator Superfamily
I6J45_RS16460	COG1024	Enoyl-CoA hydratase
I6J45_RS16465	COG1024	Enoyl-CoA hydratase
I6J45_RS16470	COG1960	acyl-CoA dehydrogenase activity
I6J45_RS16475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J45_RS16495	COG1113	amino acid transport
I6J45_RS16500	COG1113	amino acid transport
I6J45_RS16505	COG0251	oxidation-reduction process
I6J45_RS16545	COG0564	pseudouridine synthase activity
I6J45_RS16625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J45_RS16640	COG1802	Transcriptional regulator
I6J45_RS16650	COG1448	Aminotransferase
I6J45_RS16655	COG0277	FAD linked oxidase domain protein
I6J45_RS16665	COG2186	Transcriptional regulator
I6J45_RS16675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J45_RS16690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J45_RS16695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J45_RS16735	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J45_RS16750	COG2244	polysaccharide biosynthetic process
I6J45_RS16765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J45_RS16795	COG0728	peptidoglycan biosynthetic process
I6J45_RS16800	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J45_RS16855	COG0546	phosphoglycolate phosphatase activity
I6J45_RS16860	COG1028	Short-chain dehydrogenase reductase Sdr
I6J45_RS16875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J45_RS16875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J45_RS16880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J45_RS16885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J45_RS16890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J45_RS16895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J45_RS16900	COG1116	anion transmembrane transporter activity
I6J45_RS16905	COG1309	transcriptional regulator
I6J45_RS16910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J45_RS16920	COG0196	riboflavin kinase activity
I6J45_RS16925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J45_RS16935	COG1047	Peptidyl-prolyl cis-trans
I6J45_RS16975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J45_RS16980	COG0657	acetylesterase activity
I6J45_RS17030	COG2951	lytic endotransglycosylase activity
I6J45_RS17035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J45_RS17050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J45_RS17060	COG0671	phosphoesterase, PA-phosphatase related
I6J45_RS17065	COG0861	Integral membrane protein TerC family
I6J45_RS17080	COG0754	glutathionylspermidine amidase activity
I6J45_RS17090	COG0402	S-adenosylhomocysteine deaminase activity
I6J45_RS17105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J45_RS17110	COG1230	cation diffusion facilitator family transporter
I6J45_RS17120	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6J45_RS17145	COG0582	viral genome integration into host DNA
I6J45_RS17155	COG0706	membrane insertase activity
I6J45_RS17180	COG0592	DNA-directed DNA polymerase activity
I6J45_RS17190	COG0187	DNA topoisomerase II activity
I6J45_RS17205	COG0488	(ABC) transporter
I6J45_RS17230	COG0596	Alpha beta hydrolase
I6J45_RS17235	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J45_RS17240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J45_RS17270	COG0625	glutathione transferase activity
I6J45_RS17280	COG0733	neurotransmitter:sodium symporter activity
I6J45_RS17320	COG2233	PERMEase
I6J45_RS17335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J45_RS17370	COG2814	Major facilitator Superfamily
I6J45_RS17375	COG0656	L-ascorbic acid biosynthetic process
I6J45_RS17380	COG0583	DNA-binding transcription factor activity
I6J45_RS17395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J45_RS17400	COG1064	alcohol dehydrogenase
I6J45_RS17405	COG2818	Glycosylase
I6J45_RS17420	COG1194	a g-specific adenine glycosylase
I6J45_RS17435	COG5487	UPF0391 membrane protein
I6J45_RS17440	COG2983	Belongs to the UPF0260 family
I6J45_RS17445	COG2133	pyrroloquinoline quinone binding
I6J45_RS17450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J45_RS17455	COG2116	formate transmembrane transporter activity
I6J45_RS17475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J45_RS17480	COG1335	isochorismatase
I6J45_RS17485	COG0385	Bile acid
I6J45_RS17490	COG0534	Mate efflux family protein
I6J45_RS17495	COG1683	Conserved Protein
I6J45_RS17510	COG0346	lactoylglutathione lyase activity
I6J45_RS17515	COG0625	glutathione transferase activity
I6J45_RS17525	COG1113	amino acid transport
I6J45_RS17535	COG0523	cobalamin synthesis protein
I6J45_RS17545	COG2188	Transcriptional regulator
I6J45_RS17575	COG0010	Belongs to the arginase family
I6J45_RS17585	COG0546	phosphoglycolate phosphatase activity
I6J45_RS17595	COG1280	lysine exporter protein (LysE YggA)
I6J45_RS17630	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6J45_RS17660	COG0589	response to stress
I6J45_RS17690	COG4221	oxidoreductase activity
I6J45_RS17695	COG0583	DNA-binding transcription factor activity
I6J45_RS17700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J45_RS17705	COG0604	alcohol dehydrogenase
I6J45_RS17705	COG3321	synthase
I6J45_RS17715	COG0697	spore germination
I6J45_RS17720	COG0477	Major facilitator Superfamily
I6J45_RS17750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J45_RS17765	COG1979	alcohol dehydrogenase
I6J45_RS17775	COG1902	pentaerythritol trinitrate reductase activity
I6J45_RS17785	COG1309	transcriptional regulator
I6J45_RS17790	COG2130	NADP-dependent
I6J45_RS17805	COG0582	viral genome integration into host DNA
I6J45_RS17830	COG0604	alcohol dehydrogenase
I6J45_RS17855	COG1192	Involved in chromosome partitioning
I6J45_RS17860	COG1475	DNA binding
I6J45_RS17865	COG1785	Belongs to the alkaline phosphatase family
I6J45_RS17970	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6J45_RS18005	COG2184	nucleotidyltransferase activity
I6J45_RS18055	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J45_RS18055	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J45_RS18085	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6J45_RS18110	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6J45_RS18125	COG3077	Addiction module antitoxin, RelB DinJ family
I6J45_RS18235	COG1063	alcohol dehydrogenase