locus-tag	class	description
I6J47_RS00010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J47_RS00015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J47_RS00035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J47_RS00045	COG0481	GTPase activity
I6J47_RS00050	COG0681	Belongs to the peptidase S26 family
I6J47_RS00060	COG0571	ribonuclease III activity
I6J47_RS00065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J47_RS00080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J47_RS00090	COG4221	oxidoreductase activity
I6J47_RS00120	COG0436	Aminotransferase
I6J47_RS00140	COG0556	nucleotide-excision repair
I6J47_RS00150	COG2962	Rard protein
I6J47_RS00195	COG2070	2-Nitropropane dioxygenase
I6J47_RS00210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J47_RS00240	COG0415	Belongs to the DNA photolyase family
I6J47_RS00250	COG1252	NADH dehydrogenase
I6J47_RS00255	COG1686	Belongs to the peptidase S11 family
I6J47_RS00270	COG1187	pseudouridine synthase activity
I6J47_RS00285	COG0477	Major facilitator Superfamily
I6J47_RS00290	COG0583	DNA-binding transcription factor activity
I6J47_RS00295	COG1823	symporter activity
I6J47_RS00305	COG0612	Peptidase, M16
I6J47_RS00330	COG0352	thiamine-phosphate diphosphorylase activity
I6J47_RS00365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J47_RS00380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J47_RS00385	COG0076	glutamate decarboxylase activity
I6J47_RS00395	COG1522	sequence-specific DNA binding
I6J47_RS00400	COG3961	Belongs to the TPP enzyme family
I6J47_RS00405	COG1113	amino acid transport
I6J47_RS00410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J47_RS00415	COG0573	inorganic phosphate transmembrane transporter activity
I6J47_RS00425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J47_RS00430	COG0616	signal peptide processing
I6J47_RS00470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J47_RS00475	COG1686	Belongs to the peptidase S11 family
I6J47_RS00500	COG0583	DNA-binding transcription factor activity
I6J47_RS00505	COG1067	ATP-dependent peptidase activity
I6J47_RS00510	COG2211	Major facilitator Superfamily
I6J47_RS00545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J47_RS00550	COG1966	Carbon starvation protein
I6J47_RS00555	COG2879	small protein
I6J47_RS00620	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6J47_RS00640	COG4197	protein conserved in bacteria, prophage-related
I6J47_RS00790	COG4695	Portal protein
I6J47_RS00800	COG0740	serine-type endopeptidase activity
I6J47_RS00865	COG1598	PFAM Uncharacterised protein family UPF0150
I6J47_RS00870	COG1724	mRNA binding
I6J47_RS00970	COG1741	Belongs to the pirin family
I6J47_RS00985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J47_RS00990	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J47_RS00995	COG4605	iron ion homeostasis
I6J47_RS01000	COG4604	ABC transporter, ATP-binding protein
I6J47_RS01005	COG4607	ABC-type enterochelin transport system periplasmic component
I6J47_RS01010	COG4774	siderophore transport
I6J47_RS01020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J47_RS01025	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J47_RS01030	COG3433	isochorismatase activity
I6J47_RS01030	COG1535	isochorismatase
I6J47_RS01040	COG1132	(ABC) transporter
I6J47_RS01045	COG1132	(ABC) transporter
I6J47_RS01050	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J47_RS01055	COG2977	Belongs to the P-Pant transferase superfamily
I6J47_RS01060	COG1169	isochorismate synthase
I6J47_RS01075	COG3739	integral membrane protein
I6J47_RS01095	COG0302	gtp cyclohydrolase
I6J47_RS01105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J47_RS01115	COG2840	Smr protein MutS2
I6J47_RS01135	COG0308	aminopeptidase N
I6J47_RS01140	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J47_RS01155	COG0174	glutamine synthetase
I6J47_RS01165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J47_RS01200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J47_RS01205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J47_RS01210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J47_RS01230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J47_RS01235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J47_RS01240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J47_RS01255	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS01260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J47_RS01265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J47_RS01275	COG2223	nitrite transmembrane transporter activity
I6J47_RS01285	COG0024	Methionine aminopeptidase
I6J47_RS01290	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J47_RS01305	COG2207	Transcriptional regulator
I6J47_RS01330	COG2951	lytic endotransglycosylase activity
I6J47_RS01335	COG0772	Belongs to the SEDS family
I6J47_RS01350	COG0842	Transport permease protein
I6J47_RS01355	COG1131	(ABC) transporter
I6J47_RS01400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J47_RS01410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J47_RS01415	COG4215	(ABC) transporter
I6J47_RS01420	COG4160	amino acid transport
I6J47_RS01425	COG4598	ABC transporter
I6J47_RS01435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J47_RS01440	COG0826	peptidase U32
I6J47_RS01445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J47_RS01450	COG0384	phenazine biosynthesis protein PhzF
I6J47_RS01460	COG1720	tRNA m6t6A37 methyltransferase activity
I6J47_RS01470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J47_RS01485	COG0642	Histidine kinase
I6J47_RS01495	COG0494	nUDIX hydrolase
I6J47_RS01505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J47_RS01510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J47_RS01515	COG3139	Protein of unknown function (DUF1315)
I6J47_RS01525	COG1301	dicarboxylic acid transport
I6J47_RS01530	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS01545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J47_RS01555	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J47_RS01605	COG2363	Small membrane protein
I6J47_RS01625	COG0513	Belongs to the DEAD box helicase family
I6J47_RS01635	COG0778	Nitroreductase
I6J47_RS01665	COG1286	toxin biosynthetic process
I6J47_RS01690	COG4783	chaperone-mediated protein folding
I6J47_RS01695	COG1610	YqeY-like protein
I6J47_RS01750	COG1278	Cold shock
I6J47_RS01765	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6J47_RS01770	COG0786	glutamate:sodium symporter activity
I6J47_RS01775	COG0475	glutathione-regulated potassium exporter activity
I6J47_RS01775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J47_RS01790	COG1309	transcriptional regulator
I6J47_RS01800	COG2985	domain, Protein
I6J47_RS01810	COG2995	paraquat-inducible protein a
I6J47_RS01815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J47_RS01815	COG3008	intermembrane lipid transfer
I6J47_RS01825	COG2351	hydroxyisourate hydrolase activity
I6J47_RS01865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J47_RS01875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J47_RS01880	COG0642	Histidine kinase
I6J47_RS01885	COG0745	RESPONSE REGULATOR receiver
I6J47_RS01900	COG1794	racemase activity, acting on amino acids and derivatives
I6J47_RS01930	COG1301	dicarboxylic acid transport
I6J47_RS01940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J47_RS01945	COG2011	ABC-type metal ion transport system permease component
I6J47_RS01950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J47_RS01960	COG0151	Belongs to the GarS family
I6J47_RS01970	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6J47_RS02000	COG2308	Evidence 4 Homologs of previously reported genes of
I6J47_RS02010	COG1305	Transglutaminase-like
I6J47_RS02020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J47_RS02025	COG0305	Participates in initiation and elongation during chromosome replication
I6J47_RS02050	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J47_RS02055	COG1845	cytochrome c oxidase, subunit III
I6J47_RS02060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J47_RS02090	COG1649	PFAM Uncharacterised BCR, COG1649
I6J47_RS02090	COG0726	polysaccharide deacetylase
I6J47_RS02095	COG1215	transferase activity, transferring glycosyl groups
I6J47_RS02100	COG3658	cytochrome
I6J47_RS02110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J47_RS02125	COG0583	DNA-binding transcription factor activity
I6J47_RS02140	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J47_RS02145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J47_RS02150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J47_RS02165	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS02170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J47_RS02185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J47_RS02195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J47_RS02200	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J47_RS02205	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J47_RS02210	COG2205	protein histidine kinase activity
I6J47_RS02215	COG0745	RESPONSE REGULATOR receiver
I6J47_RS02220	COG0174	glutamine synthetase
I6J47_RS02235	COG0477	Major facilitator Superfamily
I6J47_RS02240	COG0729	surface antigen
I6J47_RS02270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J47_RS02275	COG2814	Major facilitator Superfamily
I6J47_RS02285	COG0583	DNA-binding transcription factor activity
I6J47_RS02300	COG1187	pseudouridine synthase activity
I6J47_RS02320	COG0802	atpase or kinase
I6J47_RS02325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J47_RS02335	COG1923	regulation of RNA biosynthetic process
I6J47_RS02340	COG0697	spore germination
I6J47_RS02355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J47_RS02365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J47_RS02370	COG0519	Catalyzes the synthesis of GMP from XMP
I6J47_RS02370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J47_RS02375	COG4302	ethanolamine ammonia-lyase activity
I6J47_RS02380	COG4303	Ethanolamine ammonia lyase large subunit
I6J47_RS02385	COG0531	amino acid
I6J47_RS02405	COG1454	alcohol dehydrogenase
I6J47_RS02410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J47_RS02435	COG0308	aminopeptidase N
I6J47_RS02475	COG1605	Chorismate mutase
I6J47_RS02490	COG4772	TonB-dependent receptor
I6J47_RS02495	COG4774	siderophore transport
I6J47_RS02550	COG3772	lysozyme
I6J47_RS02575	COG0583	DNA-binding transcription factor activity
I6J47_RS02610	COG0488	(ABC) transporter
I6J47_RS02615	COG0589	response to stress
I6J47_RS02635	COG3135	benzoate transporter
I6J47_RS02640	COG1522	sequence-specific DNA binding
I6J47_RS02650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J47_RS02655	COG0583	DNA-binding transcription factor activity
I6J47_RS02665	COG0183	Belongs to the thiolase family
I6J47_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS02675	COG2030	dehydratase
I6J47_RS02680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J47_RS02705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J47_RS02715	COG0824	Thioesterase
I6J47_RS02720	COG1454	alcohol dehydrogenase
I6J47_RS02735	COG1335	isochorismatase
I6J47_RS02750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J47_RS02780	COG0069	glutamate synthase activity
I6J47_RS02805	COG2814	Major facilitator Superfamily
I6J47_RS02820	COG0511	ligase activity, forming carbon-carbon bonds
I6J47_RS02845	COG4264	IucA IucC family
I6J47_RS02855	COG4264	IucA IucC family
I6J47_RS02860	COG2423	ornithine cyclodeaminase activity
I6J47_RS02865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J47_RS02875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J47_RS02875	COG1116	anion transmembrane transporter activity
I6J47_RS02890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J47_RS02890	COG2146	nitrite reductase [NAD(P)H] activity
I6J47_RS02895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J47_RS02900	COG0243	molybdopterin cofactor binding
I6J47_RS02910	COG0243	molybdopterin cofactor binding
I6J47_RS02915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J47_RS02930	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J47_RS02930	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J47_RS02935	COG0303	'Molybdopterin
I6J47_RS02945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J47_RS02950	COG0697	spore germination
I6J47_RS02975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J47_RS03045	COG2204	response regulator
I6J47_RS03050	COG3852	Histidine kinase
I6J47_RS03075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J47_RS03080	COG0575	Belongs to the CDS family
I6J47_RS03115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J47_RS03130	COG2137	regulation of response to DNA damage stimulus
I6J47_RS03140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J47_RS03145	COG1011	Hydrolase
I6J47_RS03160	COG1522	sequence-specific DNA binding
I6J47_RS03170	COG1113	amino acid transport
I6J47_RS03190	COG0659	secondary active sulfate transmembrane transporter activity
I6J47_RS03225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J47_RS03225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J47_RS03225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J47_RS03230	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J47_RS03235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J47_RS03235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J47_RS03255	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6J47_RS03265	COG0024	Methionine aminopeptidase
I6J47_RS03270	COG0583	DNA-binding transcription factor activity
I6J47_RS03280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6J47_RS03285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J47_RS03290	COG0517	IMP dehydrogenase activity
I6J47_RS03290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J47_RS03315	COG0552	protein localization to endoplasmic reticulum
I6J47_RS03340	COG4890	Cyd operon protein YbgT
I6J47_RS03345	COG1294	oxidase, subunit
I6J47_RS03360	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J47_RS03370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J47_RS03385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J47_RS03390	COG0569	domain protein
I6J47_RS03395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J47_RS03425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J47_RS03430	COG0542	response to heat
I6J47_RS03455	COG1902	pentaerythritol trinitrate reductase activity
I6J47_RS03455	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J47_RS03495	COG0148	phosphopyruvate hydratase activity
I6J47_RS03500	COG2323	membrane
I6J47_RS03510	COG4773	Receptor
I6J47_RS03515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6J47_RS03525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J47_RS03530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J47_RS03535	COG0183	Belongs to the thiolase family
I6J47_RS03540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J47_RS03545	COG0596	Alpha beta hydrolase
I6J47_RS03550	COG2271	Major facilitator Superfamily
I6J47_RS03555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J47_RS03560	COG3485	protocatechuate 3,4-dioxygenase
I6J47_RS03565	COG3485	protocatechuate 3,4-dioxygenase
I6J47_RS03570	COG0710	3-dehydroquinate dehydratase activity
I6J47_RS03575	COG3420	alginic acid biosynthetic process
I6J47_RS03580	COG3659	wide pore channel activity
I6J47_RS03585	COG4993	Dehydrogenase
I6J47_RS03595	COG2391	methyltransferase activity
I6J47_RS03610	COG1414	Transcriptional regulator
I6J47_RS03615	COG0583	DNA-binding transcription factor activity
I6J47_RS03620	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS03645	COG2814	Major facilitator Superfamily
I6J47_RS03655	COG0154	amidase activity
I6J47_RS03675	COG4638	Rieske (2fe-2S)
I6J47_RS03685	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS03695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J47_RS03705	COG3733	amine oxidase
I6J47_RS03715	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS03720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J47_RS03725	COG0183	Belongs to the thiolase family
I6J47_RS03730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J47_RS03735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J47_RS03745	COG4829	muconolactone delta-isomerase
I6J47_RS03750	COG4948	Mandelate Racemase Muconate Lactonizing
I6J47_RS03755	COG0583	DNA-binding transcription factor activity
I6J47_RS03765	COG2186	Transcriptional regulator
I6J47_RS03785	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS03790	COG2351	hydroxyisourate hydrolase activity
I6J47_RS03795	COG2233	PERMEase
I6J47_RS03805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J47_RS03810	COG2186	Transcriptional regulator
I6J47_RS03820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J47_RS03830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J47_RS03850	COG1902	pentaerythritol trinitrate reductase activity
I6J47_RS03850	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J47_RS03890	COG1309	transcriptional regulator
I6J47_RS03895	COG0583	DNA-binding transcription factor activity
I6J47_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS03920	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS03930	COG0318	PFAM AMP-dependent synthetase and ligase
I6J47_RS04005	COG0583	DNA-binding transcription factor activity
I6J47_RS04030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J47_RS04055	COG3210	domain, Protein
I6J47_RS04110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J47_RS04115	COG1120	ATPase activity
I6J47_RS04125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J47_RS04165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J47_RS04215	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6J47_RS04225	COG4628	conserved protein (DUF2132)
I6J47_RS04300	COG3539	Fimbrial protein
I6J47_RS04325	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J47_RS04335	COG0753	catalase activity
I6J47_RS04355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J47_RS04365	COG2205	protein histidine kinase activity
I6J47_RS04370	COG0745	RESPONSE REGULATOR receiver
I6J47_RS04375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J47_RS04380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J47_RS04435	COG1535	isochorismatase
I6J47_RS04435	COG3433	isochorismatase activity
I6J47_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS04445	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J47_RS04450	COG4149	molybdate abc transporter
I6J47_RS04455	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J47_RS04465	COG4638	Rieske (2fe-2S)
I6J47_RS04470	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J47_RS04475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J47_RS04475	COG0543	2 iron, 2 sulfur cluster binding
I6J47_RS04490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J47_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS04520	COG2207	Transcriptional regulator
I6J47_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS04530	COG2610	gluconate transmembrane transporter activity
I6J47_RS04570	COG0583	DNA-binding transcription factor activity
I6J47_RS04585	COG2031	fatty acid transporter
I6J47_RS04595	COG0583	DNA-binding transcription factor activity
I6J47_RS04600	COG0583	DNA-binding transcription factor activity
I6J47_RS04615	COG1027	Aspartate ammonia-lyase
I6J47_RS04625	COG0477	Major facilitator Superfamily
I6J47_RS04635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J47_RS04640	COG1733	regulation of RNA biosynthetic process
I6J47_RS04645	COG2207	Transcriptional regulator
I6J47_RS04645	COG3708	Transcriptional regulator
I6J47_RS04660	COG0730	response to heat
I6J47_RS04680	COG3781	membrane
I6J47_RS04685	COG1063	alcohol dehydrogenase
I6J47_RS04695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J47_RS04700	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J47_RS04705	COG0022	dehydrogenase e1 component
I6J47_RS04710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J47_RS04715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J47_RS04730	COG3706	GGDEF domain
I6J47_RS04750	COG0133	tryptophan synthase activity
I6J47_RS04760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J47_RS04790	COG0583	DNA-binding transcription factor activity
I6J47_RS04795	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J47_RS04805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J47_RS04865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J47_RS04870	COG4773	Receptor
I6J47_RS04895	COG0730	response to heat
I6J47_RS04900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J47_RS04920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J47_RS04935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J47_RS04945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J47_RS04960	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS04965	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS04970	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J47_RS04975	COG2207	Transcriptional regulator
I6J47_RS04980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J47_RS04985	COG0776	regulation of translation
I6J47_RS05010	COG0822	iron-sulfur transferase activity
I6J47_RS05015	COG0316	Belongs to the HesB IscA family
I6J47_RS05045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J47_RS05065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J47_RS05070	COG0702	epimerase
I6J47_RS05110	COG0601	transmembrane transport
I6J47_RS05115	COG0339	signal peptide processing
I6J47_RS05120	COG4166	transmembrane transport
I6J47_RS05165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J47_RS05170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J47_RS05185	COG2431	L-lysine efflux transmembrane transporter activity
I6J47_RS05200	COG0776	regulation of translation
I6J47_RS05265	COG0084	hydrolase, TatD family'
I6J47_RS05285	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J47_RS05290	COG1132	(ABC) transporter
I6J47_RS05300	COG0811	peptide transport
I6J47_RS05305	COG1475	DNA binding
I6J47_RS05310	COG1192	Involved in chromosome partitioning
I6J47_RS05320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J47_RS05325	COG3178	'Phosphotransferase
I6J47_RS05335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J47_RS05360	COG0424	maF-like protein
I6J47_RS05365	COG2850	peptidyl-arginine hydroxylation
I6J47_RS05375	COG0640	Transcriptional regulator
I6J47_RS05385	COG3619	membrane
I6J47_RS05390	COG3122	Protein conserved in bacteria
I6J47_RS05395	COG1132	(ABC) transporter
I6J47_RS05415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J47_RS05420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J47_RS05430	COG0506	proline dehydrogenase activity
I6J47_RS05430	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J47_RS05430	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J47_RS05435	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J47_RS05450	COG3698	Phosphodiester glycosidase
I6J47_RS05460	COG2353	YceI-like domain
I6J47_RS05470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J47_RS05515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J47_RS05515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J47_RS05540	COG3539	Fimbrial protein
I6J47_RS05575	COG0583	DNA-binding transcription factor activity
I6J47_RS05580	COG0697	spore germination
I6J47_RS05590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J47_RS05600	COG0583	DNA-binding transcription factor activity
I6J47_RS05615	COG1309	transcriptional regulator
I6J47_RS05630	COG1522	sequence-specific DNA binding
I6J47_RS05640	COG1126	abc transporter atp-binding protein
I6J47_RS05645	COG0765	amino acid transport
I6J47_RS05650	COG0765	amino acid transport
I6J47_RS05680	COG1464	Belongs to the NlpA lipoprotein family
I6J47_RS05690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J47_RS05695	COG2011	ABC-type metal ion transport system permease component
I6J47_RS05700	COG0012	GTP binding
I6J47_RS05725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J47_RS05760	COG1917	Cupin 2, conserved barrel domain protein
I6J47_RS05760	COG2207	Transcriptional regulator
I6J47_RS05765	COG0386	Belongs to the glutathione peroxidase family
I6J47_RS05775	COG0436	Aminotransferase
I6J47_RS05780	COG1301	dicarboxylic acid transport
I6J47_RS05815	COG3634	alkyl hydroperoxide reductase activity
I6J47_RS05830	COG0583	DNA-binding transcription factor activity
I6J47_RS05835	COG0431	NADPH-dependent FMN reductase
I6J47_RS05840	COG0798	PFAM Bile acid sodium symporter
I6J47_RS05850	COG0640	Transcriptional regulator
I6J47_RS05865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J47_RS05875	COG0583	DNA-binding transcription factor activity
I6J47_RS05885	COG1953	Uracil, thiamine, allantoin
I6J47_RS05895	COG2175	clavaminate synthase activity
I6J47_RS05900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J47_RS05905	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J47_RS05910	COG4521	taurine ABC transporter
I6J47_RS05920	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS05930	COG0477	Major facilitator Superfamily
I6J47_RS05950	COG1271	oxidase subunit
I6J47_RS05955	COG1294	oxidase, subunit
I6J47_RS05965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J47_RS05985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J47_RS06005	COG3052	prosthetic group binding
I6J47_RS06010	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6J47_RS06035	COG1346	cytolysis
I6J47_RS06045	COG0583	DNA-binding transcription factor activity
I6J47_RS06050	COG0625	glutathione transferase activity
I6J47_RS06055	COG0625	glutathione transferase activity
I6J47_RS06075	COG0583	DNA-binding transcription factor activity
I6J47_RS06080	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS06090	COG1045	serine acetyltransferase
I6J47_RS06095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J47_RS06100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J47_RS06105	COG1280	lysine exporter protein (LysE YggA)
I6J47_RS06120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J47_RS06130	COG0765	amino acid transport
I6J47_RS06135	COG0765	amino acid transport
I6J47_RS06155	COG2205	protein histidine kinase activity
I6J47_RS06155	COG0784	Response regulator, receiver
I6J47_RS06175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J47_RS06190	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS06200	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS06250	COG0583	DNA-binding transcription factor activity
I6J47_RS06260	COG2814	Major facilitator Superfamily
I6J47_RS06275	COG0318	PFAM AMP-dependent synthetase and ligase
I6J47_RS06280	COG1309	transcriptional regulator
I6J47_RS06285	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS06290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J47_RS06295	COG1024	Enoyl-CoA hydratase
I6J47_RS06300	COG4770	biotin carboxylase activity
I6J47_RS06310	COG0583	DNA-binding transcription factor activity
I6J47_RS06325	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS06335	COG2814	Major facilitator Superfamily
I6J47_RS06345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J47_RS06350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J47_RS06355	COG2814	Major facilitator Superfamily
I6J47_RS06360	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS06365	COG1024	Enoyl-CoA hydratase
I6J47_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS06375	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J47_RS06380	COG0183	Belongs to the thiolase family
I6J47_RS06390	COG2814	Major facilitator Superfamily
I6J47_RS06400	COG1024	Enoyl-CoA hydratase
I6J47_RS06415	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS06420	COG2814	Major facilitator Superfamily
I6J47_RS06425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J47_RS06440	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS06455	COG3842	ATPase activity
I6J47_RS06460	COG1840	ABC-type Fe3 transport system, periplasmic component
I6J47_RS06470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J47_RS06475	COG1414	Transcriptional regulator
I6J47_RS06495	COG3328	transposase activity
I6J47_RS06520	COG2831	hemolysin activation secretion protein
I6J47_RS06525	COG0038	chloride channel
I6J47_RS06530	COG4770	biotin carboxylase activity
I6J47_RS06550	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J47_RS06565	COG1595	DNA-templated transcription, initiation
I6J47_RS06575	COG3220	belongs to the UPF0276 family
I6J47_RS06625	COG0531	amino acid
I6J47_RS06630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J47_RS06645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J47_RS06660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J47_RS06670	COG4122	O-methyltransferase activity
I6J47_RS06700	COG1538	Outer membrane efflux protein
I6J47_RS06705	COG1137	ATPase activity
I6J47_RS06710	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J47_RS06720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J47_RS06860	COG5484	DNA packaging
I6J47_RS06860	COG3728	DNA packaging
I6J47_RS06935	COG5377	YqaJ viral recombinase family
I6J47_RS06945	COG0210	DNA helicase
I6J47_RS06990	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS07015	COG2814	Major facilitator Superfamily
I6J47_RS07025	COG0668	transmembrane transport
I6J47_RS07070	COG1309	transcriptional regulator
I6J47_RS07080	COG2226	methyltransferase
I6J47_RS07085	COG1011	Hydrolase
I6J47_RS07110	COG1278	Cold shock
I6J47_RS07115	COG1560	Kdo2-lipid A biosynthetic process
I6J47_RS07120	COG1280	lysine exporter protein (LysE YggA)
I6J47_RS07155	COG1570	exodeoxyribonuclease VII activity
I6J47_RS07235	COG2871	sodium ion transport
I6J47_RS07245	COG0583	DNA-binding transcription factor activity
I6J47_RS07255	COG4638	Rieske (2fe-2S)
I6J47_RS07260	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J47_RS07265	COG0633	Ferredoxin
I6J47_RS07265	COG0543	2 iron, 2 sulfur cluster binding
I6J47_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS07275	COG3135	benzoate transporter
I6J47_RS07280	COG2814	Major facilitator Superfamily
I6J47_RS07295	COG1643	Atp-dependent helicase
I6J47_RS07320	COG3634	alkyl hydroperoxide reductase activity
I6J47_RS07340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J47_RS07345	COG0625	glutathione transferase activity
I6J47_RS07355	COG2885	chlorophyll binding
I6J47_RS07380	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS07395	COG0542	response to heat
I6J47_RS07410	COG1765	OsmC-like protein
I6J47_RS07425	COG0667	Aldo Keto reductase
I6J47_RS07440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J47_RS07450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J47_RS07460	COG0582	viral genome integration into host DNA
I6J47_RS07475	COG3293	Transposase
I6J47_RS07480	COG1063	alcohol dehydrogenase
I6J47_RS07530	COG1196	nuclear chromosome segregation
I6J47_RS07530	COG0739	heme binding
I6J47_RS07530	COG0741	lytic transglycosylase activity
I6J47_RS07545	COG1598	PFAM Uncharacterised protein family UPF0150
I6J47_RS07650	COG0527	aspartate kinase activity
I6J47_RS07660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J47_RS07670	COG3038	cytochrome b561
I6J47_RS07675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J47_RS07680	COG2252	PERMEase
I6J47_RS07690	COG1741	Belongs to the pirin family
I6J47_RS07695	COG1309	transcriptional regulator
I6J47_RS07710	COG2072	flavoprotein involved in K transport
I6J47_RS07715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J47_RS07720	COG0583	DNA-binding transcription factor activity
I6J47_RS07735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J47_RS07765	COG1944	ATP diphosphatase activity
I6J47_RS07785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J47_RS07800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J47_RS07810	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS07820	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J47_RS07825	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS07840	COG2814	Major facilitator Superfamily
I6J47_RS07845	COG1024	Enoyl-CoA hydratase
I6J47_RS07860	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS07885	COG2186	Transcriptional regulator
I6J47_RS07890	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS07900	COG4948	Mandelate Racemase Muconate Lactonizing
I6J47_RS07905	COG2271	Major facilitator Superfamily
I6J47_RS07910	COG2721	sulfolactate sulfo-lyase activity
I6J47_RS07915	COG0697	spore germination
I6J47_RS07935	COG1113	amino acid transport
I6J47_RS07955	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS07975	COG0531	amino acid
I6J47_RS07985	COG1113	amino acid transport
I6J47_RS08020	COG2801	Transposase and inactivated derivatives
I6J47_RS08030	COG4269	membrane
I6J47_RS08050	COG1902	pentaerythritol trinitrate reductase activity
I6J47_RS08050	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J47_RS08060	COG3706	GGDEF domain
I6J47_RS08060	COG4251	negative regulation of phosphorylation
I6J47_RS08060	COG2203	Gaf domain
I6J47_RS08060	COG5001	Diguanylate cyclase
I6J47_RS08070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J47_RS08095	COG4172	Belongs to the ABC transporter superfamily
I6J47_RS08100	COG4239	(ABC) transporter, permease
I6J47_RS08105	COG4174	ABC transporter (Permease)
I6J47_RS08110	COG4166	transmembrane transport
I6J47_RS08115	COG1388	LysM domain
I6J47_RS08115	COG0741	lytic transglycosylase activity
I6J47_RS08160	COG0583	DNA-binding transcription factor activity
I6J47_RS08165	COG1279	arginine transmembrane transporter activity
I6J47_RS08185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J47_RS08190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J47_RS08195	COG0006	proline dipeptidase activity
I6J47_RS08235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J47_RS08250	COG3384	dioxygenase
I6J47_RS08260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J47_RS08265	COG2878	Part of a membrane complex involved in electron transport
I6J47_RS08270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J47_RS08295	COG0768	penicillin binding
I6J47_RS08300	COG0742	ribosomal rna small subunit methyltransferase
I6J47_RS08315	COG0830	nickel cation binding
I6J47_RS08325	COG0804	urea catabolic process
I6J47_RS08355	COG3015	lipoprotein NlpE involved in copper resistance
I6J47_RS08370	COG1253	flavin adenine dinucleotide binding
I6J47_RS08375	COG2851	Citrate transporter
I6J47_RS08425	COG1773	rubredoxin
I6J47_RS08430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J47_RS08435	COG2267	carboxylic ester hydrolase activity
I6J47_RS08440	COG0583	DNA-binding transcription factor activity
I6J47_RS08470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J47_RS08475	COG4181	ATPase activity
I6J47_RS08520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J47_RS08540	COG0306	phosphate transporter
I6J47_RS08565	COG2223	nitrite transmembrane transporter activity
I6J47_RS08570	COG2207	Transcriptional regulator
I6J47_RS08575	COG2066	Belongs to the glutaminase family
I6J47_RS08580	COG0242	peptide deformylase activity
I6J47_RS08585	COG0477	Major facilitator Superfamily
I6J47_RS08595	COG0028	Belongs to the TPP enzyme family
I6J47_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS08615	COG2267	carboxylic ester hydrolase activity
I6J47_RS08625	COG2271	Major facilitator Superfamily
I6J47_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS08660	COG1414	Transcriptional regulator
I6J47_RS08675	COG1024	Enoyl-CoA hydratase
I6J47_RS08685	COG1215	transferase activity, transferring glycosyl groups
I6J47_RS08690	COG0726	polysaccharide deacetylase
I6J47_RS08690	COG1649	PFAM Uncharacterised BCR, COG1649
I6J47_RS08700	COG4681	YaeQ
I6J47_RS08710	COG0523	cobalamin synthesis protein
I6J47_RS08720	COG1607	acyl-coa hydrolase
I6J47_RS08730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J47_RS08735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J47_RS08740	COG1309	transcriptional regulator
I6J47_RS08765	COG2040	homocysteine
I6J47_RS08770	COG0531	amino acid
I6J47_RS08825	COG1595	DNA-templated transcription, initiation
I6J47_RS08835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J47_RS08840	COG0477	Major facilitator Superfamily
I6J47_RS08920	COG0405	Gamma-glutamyltransferase
I6J47_RS08925	COG2814	Major facilitator Superfamily
I6J47_RS08935	COG2050	protein possibly involved in aromatic compounds catabolism
I6J47_RS08950	COG1090	epimerase
I6J47_RS08970	COG0420	3'-5' exonuclease activity
I6J47_RS08995	COG0735	belongs to the Fur family
I6J47_RS09000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J47_RS09005	COG2914	Belongs to the UPF0125 (RnfH) family
I6J47_RS09020	COG0121	glutamine amidotransferase
I6J47_RS09035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J47_RS09045	COG0210	DNA helicase
I6J47_RS09050	COG2885	chlorophyll binding
I6J47_RS09055	COG0204	Acyl-transferase
I6J47_RS09070	COG2894	cell division
I6J47_RS09090	COG1280	lysine exporter protein (LysE YggA)
I6J47_RS09095	COG1674	ftsk spoiiie
I6J47_RS09100	COG0492	ferredoxin-NADP+ reductase activity
I6J47_RS09105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6J47_RS09115	COG0456	acetyltransferase
I6J47_RS09130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J47_RS09135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J47_RS09145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J47_RS09160	COG1981	membrane
I6J47_RS09170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J47_RS09170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J47_RS09190	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS09195	COG4638	Rieske (2fe-2S)
I6J47_RS09200	COG0657	acetylesterase activity
I6J47_RS09210	COG0473	3-isopropylmalate dehydrogenase activity
I6J47_RS09215	COG0583	DNA-binding transcription factor activity
I6J47_RS09235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J47_RS09270	COG0358	DNA primase activity
I6J47_RS09285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6J47_RS09315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J47_RS09345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J47_RS09355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J47_RS09355	COG0351	phosphomethylpyrimidine kinase
I6J47_RS09355	COG0352	thiamine-phosphate diphosphorylase activity
I6J47_RS09360	COG1652	LysM domain
I6J47_RS09385	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J47_RS09390	COG3101	peptidyl-lysine hydroxylation
I6J47_RS09395	COG0009	L-threonylcarbamoyladenylate synthase
I6J47_RS09400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J47_RS09405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J47_RS09420	COG4106	trans-aconitate 2-methyltransferase activity
I6J47_RS09435	COG2226	methyltransferase
I6J47_RS09435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J47_RS09435	COG0596	Alpha beta hydrolase
I6J47_RS09445	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J47_RS09450	COG2223	nitrite transmembrane transporter activity
I6J47_RS09470	COG1196	nuclear chromosome segregation
I6J47_RS09480	COG0730	response to heat
I6J47_RS09495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J47_RS09505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J47_RS09550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J47_RS09555	COG0489	protein tyrosine kinase activity
I6J47_RS09565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J47_RS09565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J47_RS09600	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J47_RS09605	COG2081	HI0933 family
I6J47_RS09615	COG0668	transmembrane transport
I6J47_RS09635	COG0583	DNA-binding transcription factor activity
I6J47_RS09655	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J47_RS09660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J47_RS09690	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J47_RS09715	COG2199	diguanylate cyclase activity
I6J47_RS09730	COG0745	RESPONSE REGULATOR receiver
I6J47_RS09745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J47_RS09770	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS09815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J47_RS09830	COG0583	DNA-binding transcription factor activity
I6J47_RS09880	COG0583	DNA-binding transcription factor activity
I6J47_RS09895	COG0583	DNA-binding transcription factor activity
I6J47_RS09900	COG1053	succinate dehydrogenase
I6J47_RS09915	COG1309	transcriptional regulator
I6J47_RS09925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J47_RS09930	COG2814	Major facilitator Superfamily
I6J47_RS09935	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS09940	COG0583	DNA-binding transcription factor activity
I6J47_RS09945	COG1063	alcohol dehydrogenase
I6J47_RS09980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J47_RS09985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J47_RS09990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J47_RS10010	COG2132	Multicopper oxidase
I6J47_RS10020	COG3328	transposase activity
I6J47_RS10025	COG0561	phosphatase activity
I6J47_RS10030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J47_RS10055	COG1214	PFAM Peptidase M22, glycoprotease
I6J47_RS10115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J47_RS10120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J47_RS10125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J47_RS10185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J47_RS10195	COG1846	Transcriptional regulator
I6J47_RS10200	COG1764	response to oxidative stress
I6J47_RS10240	COG0037	tRNA processing
I6J47_RS10250	COG0248	Ppx GppA phosphatase
I6J47_RS10280	COG0072	phenylalanine-tRNA ligase activity
I6J47_RS10305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J47_RS10320	COG1238	metal cluster binding
I6J47_RS10325	COG0625	glutathione transferase activity
I6J47_RS10340	COG0318	PFAM AMP-dependent synthetase and ligase
I6J47_RS10345	COG3028	Belongs to the UPF0307 family
I6J47_RS10350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J47_RS10370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J47_RS10375	COG0617	tRNA 3'-terminal CCA addition
I6J47_RS10380	COG1555	photosystem II stabilization
I6J47_RS10385	COG3956	TIGRFAM MazG family protein
I6J47_RS10390	COG4221	oxidoreductase activity
I6J47_RS10395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J47_RS10410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J47_RS10415	COG5002	protein histidine kinase activity
I6J47_RS10415	COG2205	protein histidine kinase activity
I6J47_RS10415	COG0784	Response regulator, receiver
I6J47_RS10420	COG1024	Enoyl-CoA hydratase
I6J47_RS10425	COG2084	Dehydrogenase
I6J47_RS10430	COG3622	Belongs to the hyi family
I6J47_RS10460	COG0697	spore germination
I6J47_RS10470	COG2814	Major facilitator Superfamily
I6J47_RS10505	COG2072	flavoprotein involved in K transport
I6J47_RS10510	COG0492	ferredoxin-NADP+ reductase activity
I6J47_RS10515	COG0431	NADPH-dependent FMN reductase
I6J47_RS10520	COG0798	PFAM Bile acid sodium symporter
I6J47_RS10530	COG0640	Transcriptional regulator
I6J47_RS10565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J47_RS10590	COG2132	Multicopper oxidase
I6J47_RS10605	COG2205	protein histidine kinase activity
I6J47_RS10690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J47_RS10705	COG0583	DNA-binding transcription factor activity
I6J47_RS10715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J47_RS10725	COG0084	hydrolase, TatD family'
I6J47_RS10740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J47_RS10760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J47_RS10765	COG0440	acetolactate synthase activity
I6J47_RS10770	COG0028	Belongs to the TPP enzyme family
I6J47_RS10790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J47_RS10795	COG1136	(ABC) transporter
I6J47_RS10795	COG0577	efflux transmembrane transporter activity
I6J47_RS10825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J47_RS10830	COG1162	GTPase activity
I6J47_RS10840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J47_RS10860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J47_RS10880	COG1426	Protein conserved in bacteria
I6J47_RS10915	COG0793	Belongs to the peptidase S41A family
I6J47_RS10930	COG2267	carboxylic ester hydrolase activity
I6J47_RS10940	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS10945	COG3265	gluconokinase activity
I6J47_RS10955	COG0800	Aldolase
I6J47_RS10970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J47_RS10975	COG0857	belongs to the CobB CobQ family
I6J47_RS10975	COG0280	phosphate acetyltransferase
I6J47_RS10980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J47_RS10980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J47_RS11000	COG0740	serine-type endopeptidase activity
I6J47_RS11010	COG4774	siderophore transport
I6J47_RS11020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J47_RS11030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J47_RS11030	COG2813	Specifically methylates the guanine in position
I6J47_RS11130	COG0788	formyltetrahydrofolate deformylase activity
I6J47_RS11155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J47_RS11155	COG4651	solute:proton antiporter activity
I6J47_RS11175	COG0724	RNA recognition motif
I6J47_RS11180	COG0210	DNA helicase
I6J47_RS11205	COG1733	regulation of RNA biosynthetic process
I6J47_RS11210	COG0604	alcohol dehydrogenase
I6J47_RS11215	COG2900	Belongs to the SlyX family
I6J47_RS11220	COG0488	(ABC) transporter
I6J47_RS11230	COG1560	Kdo2-lipid A biosynthetic process
I6J47_RS11240	COG1301	dicarboxylic acid transport
I6J47_RS11295	COG0473	3-isopropylmalate dehydrogenase activity
I6J47_RS11320	COG0583	DNA-binding transcription factor activity
I6J47_RS11365	COG0583	DNA-binding transcription factor activity
I6J47_RS11375	COG0625	glutathione transferase activity
I6J47_RS11380	COG2378	regulation of single-species biofilm formation
I6J47_RS11385	COG0546	phosphoglycolate phosphatase activity
I6J47_RS11395	COG1530	ribonuclease E activity
I6J47_RS11400	COG0318	PFAM AMP-dependent synthetase and ligase
I6J47_RS11415	COG0583	DNA-binding transcription factor activity
I6J47_RS11420	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS11425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J47_RS11435	COG0534	Mate efflux family protein
I6J47_RS11450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J47_RS11475	COG0493	'glutamate synthase
I6J47_RS11485	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6J47_RS11490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J47_RS11505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J47_RS11515	COG0644	oxidoreductase
I6J47_RS11515	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J47_RS11530	COG4535	Mg2 and Co2 transporter CorC
I6J47_RS11540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J47_RS11560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J47_RS11570	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J47_RS11580	COG0484	heat shock protein binding
I6J47_RS11585	COG0789	Transcriptional regulator
I6J47_RS11590	COG0598	Magnesium transport protein CorA
I6J47_RS11595	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J47_RS11605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J47_RS11610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J47_RS11615	COG1074	ATP-dependent DNA helicase activity
I6J47_RS11620	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J47_RS11640	COG2226	methyltransferase
I6J47_RS11650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J47_RS11655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J47_RS11665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J47_RS11680	COG2111	Na H antiporter
I6J47_RS11680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J47_RS11685	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J47_RS11690	COG0651	ATP synthesis coupled electron transport
I6J47_RS11695	COG1863	multisubunit Na H antiporter MnhE subunit
I6J47_RS11700	COG2212	antiporter activity
I6J47_RS11705	COG1320	monovalent cation:proton antiporter activity
I6J47_RS11710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J47_RS11720	COG0195	Participates in both transcription termination and antitermination
I6J47_RS11770	COG0237	dephospho-CoA kinase activity
I6J47_RS11780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J47_RS11795	COG0497	DNA recombination
I6J47_RS11805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J47_RS11840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J47_RS11840	COG2169	Transcriptional regulator
I6J47_RS11845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J47_RS11915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J47_RS11930	COG0326	Molecular chaperone. Has ATPase activity
I6J47_RS11945	COG2056	Na+-H+ antiporter family
I6J47_RS12015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J47_RS12045	COG0546	phosphoglycolate phosphatase activity
I6J47_RS12050	COG1716	ATPase activity
I6J47_RS12095	COG0181	hydroxymethylbilane synthase activity
I6J47_RS12105	COG3275	phosphorelay sensor kinase activity
I6J47_RS12125	COG1538	Outer membrane efflux protein
I6J47_RS12135	COG0697	spore germination
I6J47_RS12155	COG0494	nUDIX hydrolase
I6J47_RS12160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J47_RS12165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J47_RS12170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J47_RS12175	COG0772	Belongs to the SEDS family
I6J47_RS12200	COG4974	Belongs to the 'phage' integrase family
I6J47_RS12205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J47_RS12215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J47_RS12225	COG2197	response regulator
I6J47_RS12240	COG0793	Belongs to the peptidase S41A family
I6J47_RS12245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J47_RS12250	COG0795	lipopolysaccharide-transporting ATPase activity
I6J47_RS12290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J47_RS12290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J47_RS12300	COG0004	ammonium transporteR
I6J47_RS12305	COG0347	Belongs to the P(II) protein family
I6J47_RS12315	COG0606	chelatase, subunit chli
I6J47_RS12320	COG0431	NADPH-dependent FMN reductase
I6J47_RS12325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J47_RS12330	COG0235	Class ii aldolase
I6J47_RS12335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J47_RS12355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J47_RS12370	COG0318	PFAM AMP-dependent synthetase and ligase
I6J47_RS12380	COG0477	Major facilitator Superfamily
I6J47_RS12385	COG2860	membrane
I6J47_RS12395	COG1253	flavin adenine dinucleotide binding
I6J47_RS12405	COG2814	Major facilitator Superfamily
I6J47_RS12415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J47_RS12455	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J47_RS12470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J47_RS12500	COG1309	transcriptional regulator
I6J47_RS12535	COG0758	DNA mediated transformation
I6J47_RS12545	COG0697	spore germination
I6J47_RS12550	COG1309	transcriptional regulator
I6J47_RS12565	COG0386	Belongs to the glutathione peroxidase family
I6J47_RS12580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J47_RS12590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J47_RS12630	COG1121	(ABC) transporter
I6J47_RS12635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J47_RS12640	COG1280	lysine exporter protein (LysE YggA)
I6J47_RS12645	COG2837	iron assimilation
I6J47_RS12650	COG0281	malic enzyme
I6J47_RS12695	COG0519	Catalyzes the synthesis of GMP from XMP
I6J47_RS12695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J47_RS12700	COG4399	Belongs to the UPF0754 family
I6J47_RS12705	COG2259	Doxx family
I6J47_RS12710	COG0586	Pfam SNARE associated Golgi protein
I6J47_RS12725	COG1192	Involved in chromosome partitioning
I6J47_RS12735	COG0271	Belongs to the BolA IbaG family
I6J47_RS12770	COG3756	Protein conserved in bacteria
I6J47_RS12840	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS12875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J47_RS12885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J47_RS12890	COG1113	amino acid transport
I6J47_RS12895	COG0697	spore germination
I6J47_RS12900	COG0477	Major facilitator Superfamily
I6J47_RS12905	COG1024	Enoyl-CoA hydratase
I6J47_RS12910	COG1024	Enoyl-CoA hydratase
I6J47_RS12915	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS12920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J47_RS12940	COG1113	amino acid transport
I6J47_RS12945	COG1113	amino acid transport
I6J47_RS12950	COG0251	oxidation-reduction process
I6J47_RS12990	COG0564	pseudouridine synthase activity
I6J47_RS13070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J47_RS13085	COG1802	Transcriptional regulator
I6J47_RS13095	COG1448	Aminotransferase
I6J47_RS13100	COG0277	FAD linked oxidase domain protein
I6J47_RS13110	COG2186	Transcriptional regulator
I6J47_RS13120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J47_RS13135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J47_RS13140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J47_RS13175	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J47_RS13210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J47_RS13240	COG0728	peptidoglycan biosynthetic process
I6J47_RS13245	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J47_RS13305	COG0546	phosphoglycolate phosphatase activity
I6J47_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS13325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J47_RS13325	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J47_RS13330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J47_RS13335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J47_RS13340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J47_RS13345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J47_RS13350	COG1116	anion transmembrane transporter activity
I6J47_RS13355	COG1309	transcriptional regulator
I6J47_RS13360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J47_RS13370	COG0196	riboflavin kinase activity
I6J47_RS13375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J47_RS13385	COG1047	Peptidyl-prolyl cis-trans
I6J47_RS13425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J47_RS13430	COG0657	acetylesterase activity
I6J47_RS13480	COG2951	lytic endotransglycosylase activity
I6J47_RS13485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J47_RS13500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J47_RS13510	COG0671	phosphoesterase, PA-phosphatase related
I6J47_RS13515	COG0861	Integral membrane protein TerC family
I6J47_RS13525	COG0754	glutathionylspermidine amidase activity
I6J47_RS13535	COG0402	S-adenosylhomocysteine deaminase activity
I6J47_RS13550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J47_RS13555	COG1230	cation diffusion facilitator family transporter
I6J47_RS13570	COG0706	membrane insertase activity
I6J47_RS13595	COG0592	DNA-directed DNA polymerase activity
I6J47_RS13605	COG0187	DNA topoisomerase II activity
I6J47_RS13620	COG0488	(ABC) transporter
I6J47_RS13645	COG0596	Alpha beta hydrolase
I6J47_RS13650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J47_RS13655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J47_RS13685	COG0625	glutathione transferase activity
I6J47_RS13695	COG0733	neurotransmitter:sodium symporter activity
I6J47_RS13735	COG2233	PERMEase
I6J47_RS13750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J47_RS13785	COG2814	Major facilitator Superfamily
I6J47_RS13790	COG0656	L-ascorbic acid biosynthetic process
I6J47_RS13795	COG0583	DNA-binding transcription factor activity
I6J47_RS13810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J47_RS13815	COG1064	alcohol dehydrogenase
I6J47_RS13820	COG2818	Glycosylase
I6J47_RS13835	COG1194	a g-specific adenine glycosylase
I6J47_RS13850	COG5487	UPF0391 membrane protein
I6J47_RS13855	COG2983	Belongs to the UPF0260 family
I6J47_RS13860	COG2133	pyrroloquinoline quinone binding
I6J47_RS13865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J47_RS13870	COG2116	formate transmembrane transporter activity
I6J47_RS13890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J47_RS13895	COG1335	isochorismatase
I6J47_RS13900	COG0385	Bile acid
I6J47_RS13905	COG0534	Mate efflux family protein
I6J47_RS13910	COG1683	Conserved Protein
I6J47_RS13925	COG0346	lactoylglutathione lyase activity
I6J47_RS13930	COG0625	glutathione transferase activity
I6J47_RS13940	COG1113	amino acid transport
I6J47_RS13950	COG0523	cobalamin synthesis protein
I6J47_RS13960	COG2188	Transcriptional regulator
I6J47_RS13990	COG0010	Belongs to the arginase family
I6J47_RS14035	COG3328	transposase activity
I6J47_RS14055	COG0546	phosphoglycolate phosphatase activity
I6J47_RS14060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J47_RS14070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J47_RS14080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J47_RS14085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J47_RS14185	COG0534	Mate efflux family protein
I6J47_RS14190	COG0436	Aminotransferase
I6J47_RS14195	COG2733	membrane
I6J47_RS14210	COG2918	glutathione biosynthetic process
I6J47_RS14255	COG3150	esterase
I6J47_RS14265	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6J47_RS14275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J47_RS14285	COG2233	PERMEase
I6J47_RS14290	COG2351	hydroxyisourate hydrolase activity
I6J47_RS14325	COG3706	GGDEF domain
I6J47_RS14340	COG1393	Belongs to the ArsC family
I6J47_RS14345	COG0708	Exodeoxyribonuclease III
I6J47_RS14375	COG0189	ligase activity
I6J47_RS14395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J47_RS14405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J47_RS14420	COG4942	peptidase
I6J47_RS14430	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J47_RS14440	COG2119	membrane
I6J47_RS14445	COG4774	siderophore transport
I6J47_RS14450	COG0426	domain, Protein
I6J47_RS14450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J47_RS14470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J47_RS14490	COG1902	pentaerythritol trinitrate reductase activity
I6J47_RS14495	COG1519	Transferase
I6J47_RS14500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J47_RS14505	COG0668	transmembrane transport
I6J47_RS14515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J47_RS14520	COG1335	isochorismatase
I6J47_RS14525	COG1522	sequence-specific DNA binding
I6J47_RS14550	COG0784	Response regulator, receiver
I6J47_RS14550	COG2198	Histidine kinase
I6J47_RS14550	COG2205	protein histidine kinase activity
I6J47_RS14555	COG3162	membrane
I6J47_RS14560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J47_RS14570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J47_RS14590	COG1309	transcriptional regulator
I6J47_RS14610	COG0300	oxidoreductase activity
I6J47_RS14615	COG0789	Transcriptional regulator
I6J47_RS14620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J47_RS14620	COG0351	phosphomethylpyrimidine kinase
I6J47_RS14620	COG0352	thiamine-phosphate diphosphorylase activity
I6J47_RS14630	COG2814	Major facilitator Superfamily
I6J47_RS14645	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J47_RS14655	COG1113	amino acid transport
I6J47_RS14665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J47_RS14670	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS14680	COG1335	isochorismatase
I6J47_RS14790	COG2814	Major facilitator Superfamily
I6J47_RS14795	COG0583	DNA-binding transcription factor activity
I6J47_RS14815	COG0667	Aldo Keto reductase
I6J47_RS14830	COG1309	transcriptional regulator
I6J47_RS14855	COG1733	regulation of RNA biosynthetic process
I6J47_RS14860	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J47_RS14865	COG0318	PFAM AMP-dependent synthetase and ligase
I6J47_RS14870	COG1881	PFAM PEBP family protein
I6J47_RS14880	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6J47_RS14885	COG2207	Transcriptional regulator
I6J47_RS14945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J47_RS14960	COG2329	Antibiotic biosynthesis monooxygenase
I6J47_RS14965	COG0697	spore germination
I6J47_RS14975	COG4619	ABC transporter
I6J47_RS14985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6J47_RS14995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J47_RS15025	COG0427	acetyl-CoA hydrolase
I6J47_RS15050	COG0659	secondary active sulfate transmembrane transporter activity
I6J47_RS15055	COG4221	oxidoreductase activity
I6J47_RS15060	COG2873	o-acetylhomoserine
I6J47_RS15065	COG0488	(ABC) transporter
I6J47_RS15145	COG0833	amino acid
I6J47_RS15190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J47_RS15195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J47_RS15210	COG2226	methyltransferase
I6J47_RS15260	COG0069	glutamate synthase activity
I6J47_RS15260	COG0067	glutamate synthase
I6J47_RS15260	COG0070	glutamate synthase
I6J47_RS15265	COG0493	'glutamate synthase
I6J47_RS15275	COG1704	LemA family
I6J47_RS15280	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J47_RS15300	COG3307	-O-antigen
I6J47_RS15325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J47_RS15340	COG0194	GDP metabolic process
I6J47_RS15390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J47_RS15400	COG0335	large ribosomal subunit rRNA binding
I6J47_RS15410	COG5380	lipid catabolic process
I6J47_RS15415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J47_RS15430	COG5006	permease, DMT superfamily
I6J47_RS15435	COG5006	permease, DMT superfamily
I6J47_RS15440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J47_RS15445	COG0277	FAD linked oxidase domain protein
I6J47_RS15455	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J47_RS15460	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J47_RS15475	COG1289	transmembrane transporter activity
I6J47_RS15485	COG0628	permease
I6J47_RS15490	COG1192	Involved in chromosome partitioning
I6J47_RS15520	COG0833	amino acid
I6J47_RS15525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J47_RS15530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J47_RS15540	COG1012	belongs to the aldehyde dehydrogenase family
I6J47_RS15580	COG0583	DNA-binding transcription factor activity
I6J47_RS15605	COG0752	glycyl-tRNA synthetase alpha subunit
I6J47_RS15630	COG0517	IMP dehydrogenase activity
I6J47_RS15630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J47_RS15630	COG0617	tRNA 3'-terminal CCA addition
I6J47_RS15635	COG1983	PspC domain protein
I6J47_RS15645	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS15660	COG0408	coproporphyrinogen oxidase activity
I6J47_RS15680	COG0513	Belongs to the DEAD box helicase family
I6J47_RS15690	COG1127	ABC transporter
I6J47_RS15695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J47_RS15705	COG2854	intermembrane phospholipid transfer
I6J47_RS15715	COG0598	Magnesium transport protein CorA
I6J47_RS15725	COG0494	nUDIX hydrolase
I6J47_RS15730	COG1040	competence protein
I6J47_RS15735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J47_RS15755	COG1946	Acyl-CoA thioesterase
I6J47_RS15760	COG1301	dicarboxylic acid transport
I6J47_RS15775	COG1959	2 iron, 2 sulfur cluster binding
I6J47_RS15780	COG1017	nitric oxide dioxygenase activity
I6J47_RS15780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J47_RS15790	COG0433	COG0433 Predicted ATPase
I6J47_RS15795	COG0626	cystathionine gamma-synthase activity
I6J47_RS15810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J47_RS15815	COG0088	Forms part of the polypeptide exit tunnel
I6J47_RS15950	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS15955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J47_RS15985	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J47_RS15990	COG0339	signal peptide processing
I6J47_RS15995	COG0557	exoribonuclease II activity
I6J47_RS16045	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J47_RS16050	COG1295	ribonuclease BN
I6J47_RS16085	COG1702	phosphate starvation-inducible protein PhoH
I6J47_RS16095	COG1196	nuclear chromosome segregation
I6J47_RS16095	COG0739	heme binding
I6J47_RS16095	COG0741	lytic transglycosylase activity
I6J47_RS16125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J47_RS16130	COG1183	phosphatidylcholine synthase activity
I6J47_RS16175	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS16180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J47_RS16185	COG1309	transcriptional regulator
I6J47_RS16200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J47_RS16205	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS16240	COG2826	transposase and inactivated derivatives, IS30 family
I6J47_RS16250	COG2969	positive regulation of protein catabolic process
I6J47_RS16255	COG0625	glutathione transferase activity
I6J47_RS16260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J47_RS16265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J47_RS16270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J47_RS16275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J47_RS16280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J47_RS16300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J47_RS16310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J47_RS16315	COG1408	metallophosphoesterase
I6J47_RS16320	COG2885	chlorophyll binding
I6J47_RS16320	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J47_RS16325	COG2199	diguanylate cyclase activity
I6J47_RS16395	COG1607	acyl-coa hydrolase
I6J47_RS16430	COG2350	Protein conserved in bacteria
I6J47_RS16445	COG3781	membrane
I6J47_RS16455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J47_RS16460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J47_RS16470	COG1862	Preprotein translocase
I6J47_RS16495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J47_RS16510	COG0726	polysaccharide deacetylase
I6J47_RS16525	COG1216	Glycosyl transferase, family 2
I6J47_RS16575	COG0625	glutathione transferase activity
I6J47_RS16580	COG0583	DNA-binding transcription factor activity
I6J47_RS16585	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS16590	COG1960	acyl-CoA dehydrogenase activity
I6J47_RS16600	COG2205	protein histidine kinase activity
I6J47_RS16605	COG0745	RESPONSE REGULATOR receiver
I6J47_RS16615	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6J47_RS16635	COG2096	Adenosyltransferase
I6J47_RS16640	COG4206	TonB-dependent receptor
I6J47_RS16685	COG0285	dihydrofolate synthase activity
I6J47_RS16705	COG0450	alkyl hydroperoxide reductase
I6J47_RS16720	COG0477	Major facilitator Superfamily
I6J47_RS16725	COG1272	protein, Hemolysin III
I6J47_RS16735	COG2153	protein acetylation
I6J47_RS16755	COG0183	Belongs to the thiolase family
I6J47_RS16760	COG2207	Transcriptional regulator
I6J47_RS16780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J47_RS16800	COG0183	Belongs to the thiolase family
I6J47_RS16810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J47_RS16810	COG2885	chlorophyll binding
I6J47_RS16820	COG1690	Belongs to the RtcB family
I6J47_RS16825	COG0833	amino acid
I6J47_RS16835	COG2233	PERMEase
I6J47_RS16840	COG1217	gtp-binding protein TYPA
I6J47_RS16865	COG2094	Belongs to the DNA glycosylase MPG family
I6J47_RS16870	COG4772	TonB-dependent receptor
I6J47_RS16875	COG1902	pentaerythritol trinitrate reductase activity
I6J47_RS16880	COG0679	Auxin Efflux Carrier
I6J47_RS16890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J47_RS16895	COG0354	folic acid binding
I6J47_RS16915	COG2233	PERMEase
I6J47_RS16920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J47_RS16925	COG0251	oxidation-reduction process
I6J47_RS16930	COG1335	isochorismatase
I6J47_RS16935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J47_RS16940	COG0778	Nitroreductase
I6J47_RS16945	COG0596	Alpha beta hydrolase
I6J47_RS16950	COG3189	MarR family transcriptional regulator
I6J47_RS16955	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J47_RS16960	COG3422	double-strand break repair
I6J47_RS17000	COG0840	transmembrane signaling receptor activity
I6J47_RS17020	COG5510	response to toxic substance
I6J47_RS17030	COG2832	Protein of unknown function (DUF454)
I6J47_RS17035	COG1376	ErfK ybiS ycfS ynhG family protein
I6J47_RS17075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J47_RS17085	COG1289	transmembrane transporter activity
I6J47_RS17090	COG2814	Major facilitator Superfamily
I6J47_RS17110	COG1115	amino acid carrier protein
I6J47_RS17115	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J47_RS17120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J47_RS17125	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J47_RS17130	COG3590	peptidase
I6J47_RS17155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J47_RS17165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J47_RS17170	COG1077	Cell shape determining protein MreB Mrl
I6J47_RS17175	COG1792	Involved in formation and maintenance of cell shape
I6J47_RS17180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J47_RS17185	COG0424	maF-like protein
I6J47_RS17190	COG1530	ribonuclease E activity
I6J47_RS17200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J47_RS17220	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J47_RS17245	COG2207	Transcriptional regulator
I6J47_RS17275	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J47_RS17285	COG1113	amino acid transport
I6J47_RS17290	COG2828	Protein conserved in bacteria
I6J47_RS17295	COG0142	geranyltranstransferase activity
I6J47_RS17300	COG2315	Protein conserved in bacteria
I6J47_RS17315	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J47_RS17340	COG2194	sulfuric ester hydrolase activity
I6J47_RS17345	COG0745	RESPONSE REGULATOR receiver
I6J47_RS17350	COG0642	Histidine kinase
I6J47_RS17365	COG0004	ammonium transporteR
I6J47_RS17370	COG0583	DNA-binding transcription factor activity
I6J47_RS17395	COG0525	valine-tRNA ligase activity
I6J47_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
I6J47_RS17415	COG0393	Putative heavy-metal-binding
I6J47_RS17420	COG0393	Putative heavy-metal-binding
I6J47_RS17425	COG1538	Outer membrane efflux protein
I6J47_RS17435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J47_RS17440	COG0671	phosphoesterase, PA-phosphatase related
I6J47_RS17465	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J47_RS17480	COG1648	precorrin-2 dehydrogenase activity
I6J47_RS17480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J47_RS17485	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J47_RS17520	COG0531	amino acid
I6J47_RS17535	COG0321	lipoyl(octanoyl) transferase activity
I6J47_RS17540	COG2921	Belongs to the UPF0250 family
I6J47_RS17580	COG2009	succinate dehydrogenase
I6J47_RS17585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J47_RS17590	COG1053	succinate dehydrogenase
I6J47_RS17595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J47_RS17620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J47_RS17640	COG2354	Protein conserved in bacteria
I6J47_RS17645	COG2321	neutral zinc metallopeptidase
I6J47_RS17665	COG2843	Capsule synthesis protein
I6J47_RS17685	COG0589	response to stress
I6J47_RS17695	COG0251	oxidation-reduction process
I6J47_RS17700	COG1309	transcriptional regulator
I6J47_RS17715	COG0505	Belongs to the CarA family
I6J47_RS17745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J47_RS17750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J47_RS17790	COG2264	protein methyltransferase activity
I6J47_RS17800	COG0477	Major facilitator Superfamily
I6J47_RS17805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J47_RS17820	COG1597	lipid kinase activity
I6J47_RS17825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J47_RS17850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J47_RS17855	COG0584	glycerophosphoryl diester phosphodiesterase
I6J47_RS17875	COG0741	lytic transglycosylase activity
I6J47_RS17895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J47_RS17930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J47_RS17935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J47_RS17940	COG0778	Nitroreductase
I6J47_RS17955	COG1929	Belongs to the glycerate kinase type-1 family
I6J47_RS17960	COG0243	molybdopterin cofactor binding
I6J47_RS17965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J47_RS17970	COG3339	Conserved Protein
I6J47_RS17995	COG1115	amino acid carrier protein
I6J47_RS18000	COG1113	amino acid transport
I6J47_RS18010	COG0019	diaminopimelate decarboxylase activity
I6J47_RS18020	COG1280	lysine exporter protein (LysE YggA)
I6J47_RS18025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J47_RS18055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J47_RS18085	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J47_RS18090	COG1136	(ABC) transporter
I6J47_RS18095	COG2333	competence protein COMEC
I6J47_RS18095	COG0658	competence protein
I6J47_RS18105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J47_RS18105	COG0616	signal peptide processing
I6J47_RS18110	COG0596	Alpha beta hydrolase
I6J47_RS18115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J47_RS18125	COG0628	permease
I6J47_RS18160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J47_RS18180	COG0823	Involved in the tonB-independent uptake of proteins
I6J47_RS18200	COG0824	Thioesterase
I6J47_RS18205	COG1473	amidohydrolase
I6J47_RS18225	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J47_RS18225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J47_RS18230	COG2814	Major facilitator Superfamily
I6J47_RS18235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J47_RS18240	COG1024	Enoyl-CoA hydratase
I6J47_RS18245	COG1051	belongs to the nudix hydrolase family
I6J47_RS18245	COG1056	cytidyltransferase-related domain
I6J47_RS18260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J47_RS18275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J47_RS18290	COG4625	pathogenesis
I6J47_RS18295	COG0583	DNA-binding transcription factor activity
I6J47_RS18300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J47_RS18305	COG4208	sulfate ABC transporter
I6J47_RS18310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J47_RS18410	COG1785	Belongs to the alkaline phosphatase family
I6J47_RS18415	COG1475	DNA binding
I6J47_RS18420	COG1192	Involved in chromosome partitioning
I6J47_RS18450	COG0501	Belongs to the peptidase M48B family
I6J47_RS18455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J47_RS18555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J47_RS18575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J47_RS18740	COG0358	DNA primase activity
I6J47_RS18800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J47_RS18820	COG3328	transposase activity
I6J47_RS18830	COG0582	viral genome integration into host DNA
I6J47_RS18845	COG2130	NADP-dependent
I6J47_RS18850	COG1309	transcriptional regulator
I6J47_RS18860	COG1902	pentaerythritol trinitrate reductase activity
I6J47_RS18895	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J47_RS18920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J47_RS18920	COG0475	glutathione-regulated potassium exporter activity
I6J47_RS18930	COG1063	alcohol dehydrogenase
I6J47_RS18955	COG3328	transposase activity
I6J47_RS18980	COG3657	addiction module killer protein
I6J47_RS18985	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J47_RS19010	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6J47_RS19045	COG4679	PFAM Phage derived protein Gp49-like (DUF891)