locus-tag	class	description
I6L26_RS00040	COG2918	glutathione biosynthetic process
I6L26_RS00055	COG2733	membrane
I6L26_RS00060	COG0436	Aminotransferase
I6L26_RS00065	COG0534	Mate efflux family protein
I6L26_RS00165	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L26_RS00170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L26_RS00180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L26_RS00200	COG1280	lysine exporter protein (LysE YggA)
I6L26_RS00210	COG0546	phosphoglycolate phosphatase activity
I6L26_RS00220	COG0010	Belongs to the arginase family
I6L26_RS00250	COG2188	Transcriptional regulator
I6L26_RS00260	COG0523	cobalamin synthesis protein
I6L26_RS00270	COG1113	amino acid transport
I6L26_RS00280	COG0625	glutathione transferase activity
I6L26_RS00285	COG0346	lactoylglutathione lyase activity
I6L26_RS00300	COG1683	Conserved Protein
I6L26_RS00305	COG0534	Mate efflux family protein
I6L26_RS00310	COG0385	Bile acid
I6L26_RS00315	COG1335	isochorismatase
I6L26_RS00320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L26_RS00340	COG2116	formate transmembrane transporter activity
I6L26_RS00345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L26_RS00350	COG2133	pyrroloquinoline quinone binding
I6L26_RS00355	COG2983	Belongs to the UPF0260 family
I6L26_RS00360	COG5487	UPF0391 membrane protein
I6L26_RS00375	COG1194	a g-specific adenine glycosylase
I6L26_RS00390	COG2818	Glycosylase
I6L26_RS00395	COG1064	alcohol dehydrogenase
I6L26_RS00400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L26_RS00415	COG0583	DNA-binding transcription factor activity
I6L26_RS00420	COG0656	L-ascorbic acid biosynthetic process
I6L26_RS00425	COG2814	Major facilitator Superfamily
I6L26_RS00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L26_RS00475	COG2233	PERMEase
I6L26_RS00515	COG0733	neurotransmitter:sodium symporter activity
I6L26_RS00525	COG0625	glutathione transferase activity
I6L26_RS00555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L26_RS00560	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L26_RS00565	COG0596	Alpha beta hydrolase
I6L26_RS00590	COG0488	(ABC) transporter
I6L26_RS00605	COG0187	DNA topoisomerase II activity
I6L26_RS00645	COG0706	membrane insertase activity
I6L26_RS00655	COG0582	viral genome integration into host DNA
I6L26_RS00680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6L26_RS00690	COG1230	cation diffusion facilitator family transporter
I6L26_RS00695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L26_RS00710	COG0402	S-adenosylhomocysteine deaminase activity
I6L26_RS00720	COG0754	glutathionylspermidine amidase activity
I6L26_RS00735	COG0861	Integral membrane protein TerC family
I6L26_RS00740	COG0671	phosphoesterase, PA-phosphatase related
I6L26_RS00750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L26_RS00765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L26_RS00770	COG2951	lytic endotransglycosylase activity
I6L26_RS00800	COG0583	DNA-binding transcription factor activity
I6L26_RS00820	COG0657	acetylesterase activity
I6L26_RS00835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L26_RS00875	COG1047	Peptidyl-prolyl cis-trans
I6L26_RS00885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L26_RS00890	COG0196	riboflavin kinase activity
I6L26_RS00900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L26_RS00905	COG1309	transcriptional regulator
I6L26_RS00910	COG1116	anion transmembrane transporter activity
I6L26_RS00915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L26_RS00920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L26_RS00925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L26_RS00930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L26_RS00935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L26_RS00935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L26_RS00950	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS00955	COG0546	phosphoglycolate phosphatase activity
I6L26_RS01010	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L26_RS01015	COG0728	peptidoglycan biosynthetic process
I6L26_RS01045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L26_RS01065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6L26_RS01075	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L26_RS01090	COG0463	Glycosyl transferase, family 2
I6L26_RS01090	COG1216	Glycosyl transferase, family 2
I6L26_RS01120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L26_RS01125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L26_RS01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L26_RS01155	COG2186	Transcriptional regulator
I6L26_RS01165	COG0277	FAD linked oxidase domain protein
I6L26_RS01170	COG1448	Aminotransferase
I6L26_RS01180	COG1802	Transcriptional regulator
I6L26_RS01195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L26_RS01235	COG0564	pseudouridine synthase activity
I6L26_RS01275	COG0251	oxidation-reduction process
I6L26_RS01280	COG1113	amino acid transport
I6L26_RS01285	COG1113	amino acid transport
I6L26_RS01305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L26_RS01310	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS01315	COG1024	Enoyl-CoA hydratase
I6L26_RS01320	COG1024	Enoyl-CoA hydratase
I6L26_RS01325	COG0477	Major facilitator Superfamily
I6L26_RS01330	COG3916	Acyl-homoserine-lactone synthase
I6L26_RS01360	COG0271	Belongs to the BolA IbaG family
I6L26_RS01370	COG1192	Involved in chromosome partitioning
I6L26_RS01385	COG0586	Pfam SNARE associated Golgi protein
I6L26_RS01390	COG2259	Doxx family
I6L26_RS01395	COG4399	Belongs to the UPF0754 family
I6L26_RS01400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L26_RS01400	COG0519	Catalyzes the synthesis of GMP from XMP
I6L26_RS01440	COG0281	malic enzyme
I6L26_RS01445	COG2837	iron assimilation
I6L26_RS01450	COG1280	lysine exporter protein (LysE YggA)
I6L26_RS01455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L26_RS01460	COG1121	(ABC) transporter
I6L26_RS01500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L26_RS01510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L26_RS01525	COG0386	Belongs to the glutathione peroxidase family
I6L26_RS01540	COG1309	transcriptional regulator
I6L26_RS01545	COG0697	spore germination
I6L26_RS01555	COG0758	DNA mediated transformation
I6L26_RS01620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L26_RS01635	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6L26_RS01675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L26_RS01685	COG2814	Major facilitator Superfamily
I6L26_RS01695	COG1253	flavin adenine dinucleotide binding
I6L26_RS01705	COG2860	membrane
I6L26_RS01710	COG0477	Major facilitator Superfamily
I6L26_RS01720	COG0318	PFAM AMP-dependent synthetase and ligase
I6L26_RS01735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L26_RS01755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L26_RS01760	COG0235	Class ii aldolase
I6L26_RS01765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L26_RS01770	COG0431	NADPH-dependent FMN reductase
I6L26_RS01775	COG0606	chelatase, subunit chli
I6L26_RS01785	COG0347	Belongs to the P(II) protein family
I6L26_RS01790	COG0004	ammonium transporteR
I6L26_RS01800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L26_RS01800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L26_RS01840	COG0795	lipopolysaccharide-transporting ATPase activity
I6L26_RS01845	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L26_RS01850	COG0793	Belongs to the peptidase S41A family
I6L26_RS01865	COG2197	response regulator
I6L26_RS01875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L26_RS01885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L26_RS01890	COG4974	Belongs to the 'phage' integrase family
I6L26_RS01915	COG0772	Belongs to the SEDS family
I6L26_RS01920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L26_RS01925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L26_RS01930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L26_RS01945	COG0494	nUDIX hydrolase
I6L26_RS01965	COG0697	spore germination
I6L26_RS01975	COG1538	Outer membrane efflux protein
I6L26_RS01995	COG3275	phosphorelay sensor kinase activity
I6L26_RS02005	COG0181	hydroxymethylbilane synthase activity
I6L26_RS02050	COG1716	ATPase activity
I6L26_RS02055	COG0546	phosphoglycolate phosphatase activity
I6L26_RS02085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L26_RS02155	COG2056	Na+-H+ antiporter family
I6L26_RS02170	COG0326	Molecular chaperone. Has ATPase activity
I6L26_RS02185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L26_RS02200	COG3328	transposase activity
I6L26_RS02260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L26_RS02265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L26_RS02265	COG2169	Transcriptional regulator
I6L26_RS02300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L26_RS02310	COG0497	DNA recombination
I6L26_RS02325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L26_RS02335	COG0237	dephospho-CoA kinase activity
I6L26_RS02385	COG0195	Participates in both transcription termination and antitermination
I6L26_RS02395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L26_RS02400	COG1320	monovalent cation:proton antiporter activity
I6L26_RS02405	COG2212	antiporter activity
I6L26_RS02410	COG1863	multisubunit Na H antiporter MnhE subunit
I6L26_RS02415	COG0651	ATP synthesis coupled electron transport
I6L26_RS02420	COG1006	Multisubunit Na H antiporter MnhC subunit
I6L26_RS02425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L26_RS02425	COG2111	Na H antiporter
I6L26_RS02440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L26_RS02450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L26_RS02465	COG2226	methyltransferase
I6L26_RS02485	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L26_RS02490	COG1074	ATP-dependent DNA helicase activity
I6L26_RS02495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L26_RS02500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L26_RS02510	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L26_RS02515	COG0598	Magnesium transport protein CorA
I6L26_RS02520	COG0789	Transcriptional regulator
I6L26_RS02525	COG0484	heat shock protein binding
I6L26_RS02535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L26_RS02545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L26_RS02565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L26_RS02575	COG4535	Mg2 and Co2 transporter CorC
I6L26_RS02590	COG0644	oxidoreductase
I6L26_RS02590	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L26_RS02600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L26_RS02615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L26_RS02620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L26_RS02630	COG0493	'glutamate synthase
I6L26_RS02655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L26_RS02670	COG0534	Mate efflux family protein
I6L26_RS02680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L26_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS02690	COG0583	DNA-binding transcription factor activity
I6L26_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
I6L26_RS02710	COG1530	ribonuclease E activity
I6L26_RS02720	COG0546	phosphoglycolate phosphatase activity
I6L26_RS02725	COG2378	regulation of single-species biofilm formation
I6L26_RS02730	COG0625	glutathione transferase activity
I6L26_RS02740	COG0583	DNA-binding transcription factor activity
I6L26_RS02780	COG0583	DNA-binding transcription factor activity
I6L26_RS02805	COG0473	3-isopropylmalate dehydrogenase activity
I6L26_RS02860	COG1301	dicarboxylic acid transport
I6L26_RS02870	COG1560	Kdo2-lipid A biosynthetic process
I6L26_RS02880	COG0488	(ABC) transporter
I6L26_RS02885	COG2900	Belongs to the SlyX family
I6L26_RS02895	COG1733	regulation of RNA biosynthetic process
I6L26_RS02920	COG0210	DNA helicase
I6L26_RS02925	COG0724	RNA recognition motif
I6L26_RS02945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L26_RS02945	COG4651	solute:proton antiporter activity
I6L26_RS02970	COG0788	formyltetrahydrofolate deformylase activity
I6L26_RS03070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L26_RS03070	COG2813	Specifically methylates the guanine in position
I6L26_RS03080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L26_RS03090	COG4774	siderophore transport
I6L26_RS03100	COG0740	serine-type endopeptidase activity
I6L26_RS03120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L26_RS03120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L26_RS03125	COG0280	phosphate acetyltransferase
I6L26_RS03125	COG0857	belongs to the CobB CobQ family
I6L26_RS03130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L26_RS03145	COG0800	Aldolase
I6L26_RS03155	COG3265	gluconokinase activity
I6L26_RS03160	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS03170	COG2267	carboxylic ester hydrolase activity
I6L26_RS03185	COG0793	Belongs to the peptidase S41A family
I6L26_RS03220	COG1426	Protein conserved in bacteria
I6L26_RS03240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L26_RS03260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L26_RS03270	COG1162	GTPase activity
I6L26_RS03275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L26_RS03305	COG1136	(ABC) transporter
I6L26_RS03305	COG0577	efflux transmembrane transporter activity
I6L26_RS03310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L26_RS03330	COG0028	Belongs to the TPP enzyme family
I6L26_RS03335	COG0440	acetolactate synthase activity
I6L26_RS03340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L26_RS03350	COG2826	transposase and inactivated derivatives, IS30 family
I6L26_RS03365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L26_RS03380	COG0084	hydrolase, TatD family'
I6L26_RS03390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L26_RS03400	COG0583	DNA-binding transcription factor activity
I6L26_RS03415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L26_RS03500	COG2205	protein histidine kinase activity
I6L26_RS03515	COG2132	Multicopper oxidase
I6L26_RS03540	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L26_RS03575	COG0640	Transcriptional regulator
I6L26_RS03585	COG0798	PFAM Bile acid sodium symporter
I6L26_RS03590	COG0431	NADPH-dependent FMN reductase
I6L26_RS03595	COG0492	ferredoxin-NADP+ reductase activity
I6L26_RS03600	COG2072	flavoprotein involved in K transport
I6L26_RS03635	COG2814	Major facilitator Superfamily
I6L26_RS03645	COG0697	spore germination
I6L26_RS03675	COG3622	Belongs to the hyi family
I6L26_RS03680	COG2084	Dehydrogenase
I6L26_RS03685	COG1024	Enoyl-CoA hydratase
I6L26_RS03690	COG0784	Response regulator, receiver
I6L26_RS03690	COG2205	protein histidine kinase activity
I6L26_RS03690	COG5002	protein histidine kinase activity
I6L26_RS03695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L26_RS03710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L26_RS03715	COG4221	oxidoreductase activity
I6L26_RS03720	COG3956	TIGRFAM MazG family protein
I6L26_RS03725	COG1555	photosystem II stabilization
I6L26_RS03730	COG0617	tRNA 3'-terminal CCA addition
I6L26_RS03735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L26_RS03755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L26_RS03760	COG3028	Belongs to the UPF0307 family
I6L26_RS03765	COG0318	PFAM AMP-dependent synthetase and ligase
I6L26_RS03780	COG0625	glutathione transferase activity
I6L26_RS03785	COG1238	metal cluster binding
I6L26_RS03800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L26_RS03825	COG0072	phenylalanine-tRNA ligase activity
I6L26_RS03855	COG0248	Ppx GppA phosphatase
I6L26_RS03865	COG0037	tRNA processing
I6L26_RS03905	COG1764	response to oxidative stress
I6L26_RS03910	COG1846	Transcriptional regulator
I6L26_RS03920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L26_RS03980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L26_RS03985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L26_RS03990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L26_RS04050	COG1214	PFAM Peptidase M22, glycoprotease
I6L26_RS04065	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L26_RS04075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L26_RS04080	COG0561	phosphatase activity
I6L26_RS04090	COG2132	Multicopper oxidase
I6L26_RS04110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L26_RS04115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L26_RS04120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L26_RS04150	COG1063	alcohol dehydrogenase
I6L26_RS04155	COG0583	DNA-binding transcription factor activity
I6L26_RS04160	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS04165	COG2814	Major facilitator Superfamily
I6L26_RS04170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L26_RS04180	COG1309	transcriptional regulator
I6L26_RS04195	COG1053	succinate dehydrogenase
I6L26_RS04200	COG0583	DNA-binding transcription factor activity
I6L26_RS04215	COG0583	DNA-binding transcription factor activity
I6L26_RS04270	COG0583	DNA-binding transcription factor activity
I6L26_RS04285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L26_RS04340	COG0438	transferase activity, transferring glycosyl groups
I6L26_RS04345	COG0110	maltose O-acetyltransferase activity
I6L26_RS04385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L26_RS04400	COG0745	RESPONSE REGULATOR receiver
I6L26_RS04415	COG2199	diguanylate cyclase activity
I6L26_RS04440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L26_RS04470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L26_RS04475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L26_RS04495	COG0583	DNA-binding transcription factor activity
I6L26_RS04515	COG0668	transmembrane transport
I6L26_RS04525	COG2081	HI0933 family
I6L26_RS04530	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L26_RS04565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L26_RS04565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L26_RS04575	COG0489	protein tyrosine kinase activity
I6L26_RS04625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L26_RS04635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L26_RS04650	COG0730	response to heat
I6L26_RS04660	COG1196	nuclear chromosome segregation
I6L26_RS04680	COG2223	nitrite transmembrane transporter activity
I6L26_RS04685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6L26_RS04695	COG0596	Alpha beta hydrolase
I6L26_RS04695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L26_RS04695	COG2226	methyltransferase
I6L26_RS04710	COG4106	trans-aconitate 2-methyltransferase activity
I6L26_RS04725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L26_RS04730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L26_RS04735	COG0009	L-threonylcarbamoyladenylate synthase
I6L26_RS04740	COG3101	peptidyl-lysine hydroxylation
I6L26_RS04745	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L26_RS04770	COG1652	LysM domain
I6L26_RS04775	COG0352	thiamine-phosphate diphosphorylase activity
I6L26_RS04775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L26_RS04775	COG0351	phosphomethylpyrimidine kinase
I6L26_RS04785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L26_RS04815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L26_RS04845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L26_RS04860	COG0358	DNA primase activity
I6L26_RS04895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L26_RS04915	COG0583	DNA-binding transcription factor activity
I6L26_RS04920	COG0473	3-isopropylmalate dehydrogenase activity
I6L26_RS04930	COG0657	acetylesterase activity
I6L26_RS04935	COG4638	Rieske (2fe-2S)
I6L26_RS04940	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS04960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L26_RS04960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L26_RS04970	COG1981	membrane
I6L26_RS04985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L26_RS04995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L26_RS05000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L26_RS05015	COG0456	acetyltransferase
I6L26_RS05025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L26_RS05030	COG0492	ferredoxin-NADP+ reductase activity
I6L26_RS05035	COG1674	ftsk spoiiie
I6L26_RS05040	COG1280	lysine exporter protein (LysE YggA)
I6L26_RS05055	COG2894	cell division
I6L26_RS05070	COG0204	Acyl-transferase
I6L26_RS05075	COG2885	chlorophyll binding
I6L26_RS05080	COG0210	DNA helicase
I6L26_RS05090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L26_RS05105	COG0121	glutamine amidotransferase
I6L26_RS05120	COG2914	Belongs to the UPF0125 (RnfH) family
I6L26_RS05125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L26_RS05130	COG0735	belongs to the Fur family
I6L26_RS05155	COG0420	3'-5' exonuclease activity
I6L26_RS05175	COG1090	epimerase
I6L26_RS05190	COG2050	protein possibly involved in aromatic compounds catabolism
I6L26_RS05200	COG2814	Major facilitator Superfamily
I6L26_RS05205	COG0405	Gamma-glutamyltransferase
I6L26_RS05215	COG1401	restriction endodeoxyribonuclease activity
I6L26_RS05260	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6L26_RS05270	COG2814	Major facilitator Superfamily
I6L26_RS05275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L26_RS05325	COG0531	amino acid
I6L26_RS05330	COG2040	homocysteine
I6L26_RS05355	COG1309	transcriptional regulator
I6L26_RS05360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L26_RS05365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L26_RS05375	COG1607	acyl-coa hydrolase
I6L26_RS05385	COG0523	cobalamin synthesis protein
I6L26_RS05395	COG4681	YaeQ
I6L26_RS05405	COG0726	polysaccharide deacetylase
I6L26_RS05405	COG1649	PFAM Uncharacterised BCR, COG1649
I6L26_RS05410	COG1215	transferase activity, transferring glycosyl groups
I6L26_RS05420	COG1024	Enoyl-CoA hydratase
I6L26_RS05435	COG1414	Transcriptional regulator
I6L26_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS05465	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L26_RS05470	COG2271	Major facilitator Superfamily
I6L26_RS05480	COG2267	carboxylic ester hydrolase activity
I6L26_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS05500	COG0028	Belongs to the TPP enzyme family
I6L26_RS05510	COG0477	Major facilitator Superfamily
I6L26_RS05515	COG0242	peptide deformylase activity
I6L26_RS05520	COG2066	Belongs to the glutaminase family
I6L26_RS05525	COG2207	Transcriptional regulator
I6L26_RS05530	COG2223	nitrite transmembrane transporter activity
I6L26_RS05555	COG0306	phosphate transporter
I6L26_RS05575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L26_RS05620	COG4181	ATPase activity
I6L26_RS05625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L26_RS05655	COG0583	DNA-binding transcription factor activity
I6L26_RS05660	COG2267	carboxylic ester hydrolase activity
I6L26_RS05665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L26_RS05670	COG1773	rubredoxin
I6L26_RS05720	COG2851	Citrate transporter
I6L26_RS05725	COG1253	flavin adenine dinucleotide binding
I6L26_RS05740	COG3015	lipoprotein NlpE involved in copper resistance
I6L26_RS05765	COG0804	urea catabolic process
I6L26_RS05775	COG0830	nickel cation binding
I6L26_RS05790	COG0742	ribosomal rna small subunit methyltransferase
I6L26_RS05795	COG0768	penicillin binding
I6L26_RS05820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L26_RS05825	COG2878	Part of a membrane complex involved in electron transport
I6L26_RS05830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L26_RS05840	COG3384	dioxygenase
I6L26_RS05855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L26_RS05895	COG0006	proline dipeptidase activity
I6L26_RS05900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L26_RS05905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L26_RS05915	COG0789	Transcriptional regulator
I6L26_RS05925	COG1279	arginine transmembrane transporter activity
I6L26_RS05930	COG0583	DNA-binding transcription factor activity
I6L26_RS05975	COG0741	lytic transglycosylase activity
I6L26_RS05975	COG1388	LysM domain
I6L26_RS05975	COG0741	lytic transglycosylase activity
I6L26_RS05975	COG1388	LysM domain
I6L26_RS05980	COG4166	transmembrane transport
I6L26_RS05985	COG4174	ABC transporter (Permease)
I6L26_RS05990	COG4239	(ABC) transporter, permease
I6L26_RS05995	COG4172	Belongs to the ABC transporter superfamily
I6L26_RS06020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L26_RS06030	COG3706	GGDEF domain
I6L26_RS06030	COG4251	negative regulation of phosphorylation
I6L26_RS06030	COG5001	Diguanylate cyclase
I6L26_RS06030	COG2203	Gaf domain
I6L26_RS06040	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L26_RS06040	COG1902	pentaerythritol trinitrate reductase activity
I6L26_RS06060	COG4269	membrane
I6L26_RS06095	COG1113	amino acid transport
I6L26_RS06105	COG0531	amino acid
I6L26_RS06125	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS06145	COG1113	amino acid transport
I6L26_RS06150	COG2831	hemolysin activation secretion protein
I6L26_RS06155	COG3210	domain, Protein
I6L26_RS06175	COG0697	spore germination
I6L26_RS06180	COG2721	sulfolactate sulfo-lyase activity
I6L26_RS06185	COG2271	Major facilitator Superfamily
I6L26_RS06190	COG4948	Mandelate Racemase Muconate Lactonizing
I6L26_RS06200	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS06205	COG2186	Transcriptional regulator
I6L26_RS06230	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS06240	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS06245	COG1024	Enoyl-CoA hydratase
I6L26_RS06250	COG2814	Major facilitator Superfamily
I6L26_RS06270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L26_RS06285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L26_RS06305	COG1944	ATP diphosphatase activity
I6L26_RS06335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L26_RS06350	COG0583	DNA-binding transcription factor activity
I6L26_RS06355	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6L26_RS06360	COG2072	flavoprotein involved in K transport
I6L26_RS06375	COG1309	transcriptional regulator
I6L26_RS06380	COG1741	Belongs to the pirin family
I6L26_RS06390	COG2252	PERMEase
I6L26_RS06395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L26_RS06400	COG3038	cytochrome b561
I6L26_RS06410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L26_RS06420	COG0527	aspartate kinase activity
I6L26_RS06430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L26_RS06440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L26_RS06455	COG0667	Aldo Keto reductase
I6L26_RS06470	COG1765	OsmC-like protein
I6L26_RS06485	COG0542	response to heat
I6L26_RS06520	COG2885	chlorophyll binding
I6L26_RS06530	COG0625	glutathione transferase activity
I6L26_RS06550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L26_RS06570	COG3634	alkyl hydroperoxide reductase activity
I6L26_RS06595	COG1643	Atp-dependent helicase
I6L26_RS06610	COG2814	Major facilitator Superfamily
I6L26_RS06615	COG3135	benzoate transporter
I6L26_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS06625	COG0633	Ferredoxin
I6L26_RS06625	COG0543	2 iron, 2 sulfur cluster binding
I6L26_RS06635	COG4638	Rieske (2fe-2S)
I6L26_RS06645	COG0583	DNA-binding transcription factor activity
I6L26_RS06655	COG2871	sodium ion transport
I6L26_RS06740	COG1570	exodeoxyribonuclease VII activity
I6L26_RS06775	COG1280	lysine exporter protein (LysE YggA)
I6L26_RS06780	COG1560	Kdo2-lipid A biosynthetic process
I6L26_RS06785	COG1278	Cold shock
I6L26_RS06810	COG2226	methyltransferase
I6L26_RS06875	COG0668	transmembrane transport
I6L26_RS06885	COG2814	Major facilitator Superfamily
I6L26_RS06925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L26_RS06935	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L26_RS06940	COG1137	ATPase activity
I6L26_RS06975	COG4122	O-methyltransferase activity
I6L26_RS06985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L26_RS07000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L26_RS07015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L26_RS07020	COG0531	amino acid
I6L26_RS07025	COG1522	sequence-specific DNA binding
I6L26_RS07050	COG1733	regulation of RNA biosynthetic process
I6L26_RS07055	COG0753	catalase activity
I6L26_RS07060	COG3038	cytochrome b561
I6L26_RS07115	COG3712	iron ion homeostasis
I6L26_RS07120	COG1595	DNA-templated transcription, initiation
I6L26_RS07130	COG1051	belongs to the nudix hydrolase family
I6L26_RS07145	COG1733	regulation of RNA biosynthetic process
I6L26_RS07150	COG0702	epimerase
I6L26_RS07205	COG3220	belongs to the UPF0276 family
I6L26_RS07215	COG1595	DNA-templated transcription, initiation
I6L26_RS07225	COG0583	DNA-binding transcription factor activity
I6L26_RS07230	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L26_RS07250	COG4770	biotin carboxylase activity
I6L26_RS07255	COG0038	chloride channel
I6L26_RS07260	COG2831	hemolysin activation secretion protein
I6L26_RS07265	COG3210	domain, Protein
I6L26_RS07295	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L26_RS07300	COG1063	alcohol dehydrogenase
I6L26_RS07345	COG0666	response to abiotic stimulus
I6L26_RS07350	COG0590	tRNA wobble adenosine to inosine editing
I6L26_RS07355	COG2807	transmembrane transport
I6L26_RS07370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L26_RS07375	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L26_RS07385	COG0789	Transcriptional regulator
I6L26_RS07400	COG1760	l-serine dehydratase
I6L26_RS07405	COG2030	dehydratase
I6L26_RS07405	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS07410	COG3396	Phenylacetate-CoA oxygenase
I6L26_RS07415	COG3460	Phenylacetate-CoA oxygenase
I6L26_RS07420	COG3396	Phenylacetate-CoA oxygenase
I6L26_RS07425	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L26_RS07430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L26_RS07435	COG1024	Enoyl-CoA hydratase
I6L26_RS07440	COG1024	Enoyl-CoA hydratase
I6L26_RS07445	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L26_RS07450	COG0183	Belongs to the thiolase family
I6L26_RS07455	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6L26_RS07460	COG3327	negative regulation of DNA-templated transcription, initiation
I6L26_RS07470	COG2050	protein possibly involved in aromatic compounds catabolism
I6L26_RS07475	COG0583	DNA-binding transcription factor activity
I6L26_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS07510	COG0583	DNA-binding transcription factor activity
I6L26_RS07520	COG1414	Transcriptional regulator
I6L26_RS07525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L26_RS07540	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L26_RS07545	COG3842	ATPase activity
I6L26_RS07560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L26_RS07565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L26_RS07570	COG2814	Major facilitator Superfamily
I6L26_RS07575	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS07590	COG1024	Enoyl-CoA hydratase
I6L26_RS07600	COG2814	Major facilitator Superfamily
I6L26_RS07610	COG0183	Belongs to the thiolase family
I6L26_RS07615	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L26_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS07625	COG1024	Enoyl-CoA hydratase
I6L26_RS07630	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS07635	COG2814	Major facilitator Superfamily
I6L26_RS07640	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L26_RS07645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L26_RS07655	COG2814	Major facilitator Superfamily
I6L26_RS07665	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS07680	COG0583	DNA-binding transcription factor activity
I6L26_RS07690	COG4770	biotin carboxylase activity
I6L26_RS07695	COG1024	Enoyl-CoA hydratase
I6L26_RS07700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L26_RS07705	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS07710	COG1309	transcriptional regulator
I6L26_RS07715	COG0318	PFAM AMP-dependent synthetase and ligase
I6L26_RS07730	COG2814	Major facilitator Superfamily
I6L26_RS07740	COG0583	DNA-binding transcription factor activity
I6L26_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS07805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L26_RS07825	COG2205	protein histidine kinase activity
I6L26_RS07825	COG0784	Response regulator, receiver
I6L26_RS07845	COG0765	amino acid transport
I6L26_RS07850	COG0765	amino acid transport
I6L26_RS07860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L26_RS07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L26_RS07880	COG1280	lysine exporter protein (LysE YggA)
I6L26_RS07885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L26_RS07890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L26_RS07895	COG1045	serine acetyltransferase
I6L26_RS07910	COG0583	DNA-binding transcription factor activity
I6L26_RS07930	COG0625	glutathione transferase activity
I6L26_RS07935	COG0625	glutathione transferase activity
I6L26_RS07940	COG0583	DNA-binding transcription factor activity
I6L26_RS07950	COG1346	cytolysis
I6L26_RS07975	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6L26_RS07980	COG3052	prosthetic group binding
I6L26_RS08000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L26_RS08020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L26_RS08030	COG1294	oxidase, subunit
I6L26_RS08035	COG1271	oxidase subunit
I6L26_RS08055	COG0477	Major facilitator Superfamily
I6L26_RS08065	COG4521	taurine ABC transporter
I6L26_RS08070	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L26_RS08075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L26_RS08080	COG2175	clavaminate synthase activity
I6L26_RS08090	COG1953	Uracil, thiamine, allantoin
I6L26_RS08100	COG0583	DNA-binding transcription factor activity
I6L26_RS08110	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6L26_RS08125	COG0640	Transcriptional regulator
I6L26_RS08135	COG0798	PFAM Bile acid sodium symporter
I6L26_RS08140	COG0431	NADPH-dependent FMN reductase
I6L26_RS08145	COG0583	DNA-binding transcription factor activity
I6L26_RS08160	COG3634	alkyl hydroperoxide reductase activity
I6L26_RS08195	COG1301	dicarboxylic acid transport
I6L26_RS08200	COG0436	Aminotransferase
I6L26_RS08210	COG0386	Belongs to the glutathione peroxidase family
I6L26_RS08215	COG2207	Transcriptional regulator
I6L26_RS08215	COG1917	Cupin 2, conserved barrel domain protein
I6L26_RS08250	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L26_RS08275	COG0012	GTP binding
I6L26_RS08280	COG2011	ABC-type metal ion transport system permease component
I6L26_RS08285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L26_RS08295	COG1464	Belongs to the NlpA lipoprotein family
I6L26_RS08325	COG0765	amino acid transport
I6L26_RS08330	COG0765	amino acid transport
I6L26_RS08335	COG1126	abc transporter atp-binding protein
I6L26_RS08345	COG1522	sequence-specific DNA binding
I6L26_RS08360	COG1309	transcriptional regulator
I6L26_RS08375	COG0583	DNA-binding transcription factor activity
I6L26_RS08385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L26_RS08395	COG0697	spore germination
I6L26_RS08400	COG0583	DNA-binding transcription factor activity
I6L26_RS08435	COG3539	Fimbrial protein
I6L26_RS08460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L26_RS08460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L26_RS08505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L26_RS08515	COG2353	YceI-like domain
I6L26_RS08525	COG3698	Phosphodiester glycosidase
I6L26_RS08540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6L26_RS08545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L26_RS08545	COG0506	proline dehydrogenase activity
I6L26_RS08545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L26_RS08555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L26_RS08560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L26_RS08580	COG1132	(ABC) transporter
I6L26_RS08585	COG3122	Protein conserved in bacteria
I6L26_RS08590	COG3619	membrane
I6L26_RS08600	COG0640	Transcriptional regulator
I6L26_RS08610	COG2850	peptidyl-arginine hydroxylation
I6L26_RS08615	COG0424	maF-like protein
I6L26_RS08640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L26_RS08650	COG3178	'Phosphotransferase
I6L26_RS08655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L26_RS08665	COG1192	Involved in chromosome partitioning
I6L26_RS08670	COG1475	DNA binding
I6L26_RS08675	COG0811	peptide transport
I6L26_RS08685	COG1132	(ABC) transporter
I6L26_RS08690	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L26_RS08710	COG0084	hydrolase, TatD family'
I6L26_RS08775	COG0776	regulation of translation
I6L26_RS08790	COG2431	L-lysine efflux transmembrane transporter activity
I6L26_RS08805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L26_RS08810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L26_RS08855	COG4166	transmembrane transport
I6L26_RS08860	COG0339	signal peptide processing
I6L26_RS08865	COG0601	transmembrane transport
I6L26_RS08905	COG0702	epimerase
I6L26_RS08910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L26_RS08930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L26_RS08960	COG0316	Belongs to the HesB IscA family
I6L26_RS08965	COG0822	iron-sulfur transferase activity
I6L26_RS08990	COG0776	regulation of translation
I6L26_RS08995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L26_RS09000	COG2207	Transcriptional regulator
I6L26_RS09005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L26_RS09010	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS09015	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS09030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L26_RS09040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L26_RS09055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6L26_RS09075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L26_RS09080	COG0730	response to heat
I6L26_RS09105	COG4773	Receptor
I6L26_RS09110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L26_RS09170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L26_RS09180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L26_RS09185	COG0583	DNA-binding transcription factor activity
I6L26_RS09215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L26_RS09225	COG0133	tryptophan synthase activity
I6L26_RS09245	COG3706	GGDEF domain
I6L26_RS09260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L26_RS09265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6L26_RS09270	COG0022	dehydrogenase e1 component
I6L26_RS09275	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L26_RS09280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L26_RS09290	COG1063	alcohol dehydrogenase
I6L26_RS09295	COG3781	membrane
I6L26_RS09315	COG0730	response to heat
I6L26_RS09335	COG1733	regulation of RNA biosynthetic process
I6L26_RS09340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L26_RS09350	COG0477	Major facilitator Superfamily
I6L26_RS09360	COG1027	Aspartate ammonia-lyase
I6L26_RS09375	COG0583	DNA-binding transcription factor activity
I6L26_RS09380	COG0583	DNA-binding transcription factor activity
I6L26_RS09385	COG0183	Belongs to the thiolase family
I6L26_RS09390	COG2031	fatty acid transporter
I6L26_RS09405	COG0583	DNA-binding transcription factor activity
I6L26_RS09445	COG2610	gluconate transmembrane transporter activity
I6L26_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS09455	COG2207	Transcriptional regulator
I6L26_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS09485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L26_RS09500	COG0543	2 iron, 2 sulfur cluster binding
I6L26_RS09500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L26_RS09505	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L26_RS09510	COG4638	Rieske (2fe-2S)
I6L26_RS09520	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L26_RS09525	COG4149	molybdate abc transporter
I6L26_RS09530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L26_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS09540	COG1535	isochorismatase
I6L26_RS09540	COG3433	isochorismatase activity
I6L26_RS09595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L26_RS09600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L26_RS09605	COG0745	RESPONSE REGULATOR receiver
I6L26_RS09610	COG2205	protein histidine kinase activity
I6L26_RS09620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L26_RS09640	COG0753	catalase activity
I6L26_RS09650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L26_RS09675	COG3539	Fimbrial protein
I6L26_RS09685	COG4628	conserved protein (DUF2132)
I6L26_RS09695	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L26_RS09745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L26_RS09795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L26_RS09805	COG1120	ATPase activity
I6L26_RS09810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L26_RS09865	COG3210	domain, Protein
I6L26_RS09870	COG2831	hemolysin activation secretion protein
I6L26_RS09885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L26_RS09890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L26_RS09980	COG1309	transcriptional regulator
I6L26_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
I6L26_RS10000	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS10025	COG0583	DNA-binding transcription factor activity
I6L26_RS10030	COG1309	transcriptional regulator
I6L26_RS10070	COG1902	pentaerythritol trinitrate reductase activity
I6L26_RS10070	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L26_RS10090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L26_RS10100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L26_RS10110	COG2186	Transcriptional regulator
I6L26_RS10115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L26_RS10125	COG2233	PERMEase
I6L26_RS10130	COG2351	hydroxyisourate hydrolase activity
I6L26_RS10135	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS10155	COG2186	Transcriptional regulator
I6L26_RS10165	COG0583	DNA-binding transcription factor activity
I6L26_RS10170	COG4948	Mandelate Racemase Muconate Lactonizing
I6L26_RS10175	COG4829	muconolactone delta-isomerase
I6L26_RS10185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L26_RS10190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L26_RS10195	COG0183	Belongs to the thiolase family
I6L26_RS10200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L26_RS10205	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS10215	COG3733	amine oxidase
I6L26_RS10225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L26_RS10235	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS10245	COG4638	Rieske (2fe-2S)
I6L26_RS10265	COG0154	amidase activity
I6L26_RS10275	COG2814	Major facilitator Superfamily
I6L26_RS10300	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS10305	COG0583	DNA-binding transcription factor activity
I6L26_RS10310	COG1414	Transcriptional regulator
I6L26_RS10325	COG2391	methyltransferase activity
I6L26_RS10335	COG4993	Dehydrogenase
I6L26_RS10340	COG3659	wide pore channel activity
I6L26_RS10345	COG3420	alginic acid biosynthetic process
I6L26_RS10350	COG0710	3-dehydroquinate dehydratase activity
I6L26_RS10355	COG3485	protocatechuate 3,4-dioxygenase
I6L26_RS10360	COG3485	protocatechuate 3,4-dioxygenase
I6L26_RS10365	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L26_RS10370	COG2271	Major facilitator Superfamily
I6L26_RS10375	COG0596	Alpha beta hydrolase
I6L26_RS10380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L26_RS10385	COG0183	Belongs to the thiolase family
I6L26_RS10390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L26_RS10395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L26_RS10405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L26_RS10410	COG4773	Receptor
I6L26_RS10420	COG2323	membrane
I6L26_RS10425	COG0148	phosphopyruvate hydratase activity
I6L26_RS10465	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L26_RS10465	COG1902	pentaerythritol trinitrate reductase activity
I6L26_RS10480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L26_RS10490	COG0542	response to heat
I6L26_RS10495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L26_RS10525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L26_RS10530	COG0569	domain protein
I6L26_RS10535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L26_RS10550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L26_RS10560	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L26_RS10575	COG1294	oxidase, subunit
I6L26_RS10580	COG4890	Cyd operon protein YbgT
I6L26_RS10605	COG0552	protein localization to endoplasmic reticulum
I6L26_RS10630	COG0517	IMP dehydrogenase activity
I6L26_RS10630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L26_RS10635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L26_RS10640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L26_RS10650	COG0583	DNA-binding transcription factor activity
I6L26_RS10655	COG0024	Methionine aminopeptidase
I6L26_RS10665	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6L26_RS10685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L26_RS10685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L26_RS10690	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L26_RS10695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L26_RS10695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L26_RS10695	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L26_RS10730	COG0659	secondary active sulfate transmembrane transporter activity
I6L26_RS10745	COG0657	acetylesterase activity
I6L26_RS10750	COG1113	amino acid transport
I6L26_RS10760	COG1522	sequence-specific DNA binding
I6L26_RS10775	COG1011	Hydrolase
I6L26_RS10780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L26_RS10790	COG2137	regulation of response to DNA damage stimulus
I6L26_RS10805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L26_RS10840	COG0575	Belongs to the CDS family
I6L26_RS10845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L26_RS10870	COG3852	Histidine kinase
I6L26_RS10875	COG2204	response regulator
I6L26_RS10955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L26_RS10980	COG0697	spore germination
I6L26_RS10985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L26_RS10995	COG0303	'Molybdopterin
I6L26_RS11000	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L26_RS11000	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L26_RS11015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L26_RS11020	COG0243	molybdopterin cofactor binding
I6L26_RS11030	COG0243	molybdopterin cofactor binding
I6L26_RS11035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L26_RS11040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L26_RS11040	COG2146	nitrite reductase [NAD(P)H] activity
I6L26_RS11055	COG1116	anion transmembrane transporter activity
I6L26_RS11055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L26_RS11065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L26_RS11070	COG2423	ornithine cyclodeaminase activity
I6L26_RS11075	COG4264	IucA IucC family
I6L26_RS11085	COG4264	IucA IucC family
I6L26_RS11110	COG0511	ligase activity, forming carbon-carbon bonds
I6L26_RS11125	COG2814	Major facilitator Superfamily
I6L26_RS11150	COG0069	glutamate synthase activity
I6L26_RS11180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L26_RS11195	COG1335	isochorismatase
I6L26_RS11210	COG1454	alcohol dehydrogenase
I6L26_RS11215	COG0824	Thioesterase
I6L26_RS11230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L26_RS11255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L26_RS11260	COG2030	dehydratase
I6L26_RS11265	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS11270	COG0183	Belongs to the thiolase family
I6L26_RS11280	COG0583	DNA-binding transcription factor activity
I6L26_RS11285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L26_RS11295	COG1522	sequence-specific DNA binding
I6L26_RS11300	COG3135	benzoate transporter
I6L26_RS11320	COG0589	response to stress
I6L26_RS11325	COG0488	(ABC) transporter
I6L26_RS11360	COG0583	DNA-binding transcription factor activity
I6L26_RS11385	COG1733	regulation of RNA biosynthetic process
I6L26_RS11395	COG3772	lysozyme
I6L26_RS11450	COG4772	TonB-dependent receptor
I6L26_RS11465	COG1605	Chorismate mutase
I6L26_RS11505	COG0308	aminopeptidase N
I6L26_RS11535	COG1454	alcohol dehydrogenase
I6L26_RS11555	COG0531	amino acid
I6L26_RS11560	COG4303	Ethanolamine ammonia lyase large subunit
I6L26_RS11565	COG4302	ethanolamine ammonia-lyase activity
I6L26_RS11570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L26_RS11570	COG0519	Catalyzes the synthesis of GMP from XMP
I6L26_RS11575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L26_RS11600	COG0697	spore germination
I6L26_RS11605	COG1923	regulation of RNA biosynthetic process
I6L26_RS11615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L26_RS11620	COG0802	atpase or kinase
I6L26_RS11640	COG1187	pseudouridine synthase activity
I6L26_RS11655	COG0583	DNA-binding transcription factor activity
I6L26_RS11665	COG2814	Major facilitator Superfamily
I6L26_RS11670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L26_RS11700	COG0729	surface antigen
I6L26_RS11720	COG0174	glutamine synthetase
I6L26_RS11725	COG0745	RESPONSE REGULATOR receiver
I6L26_RS11730	COG2205	protein histidine kinase activity
I6L26_RS11740	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6L26_RS11745	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6L26_RS11755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L26_RS11770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L26_RS11775	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS11790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L26_RS11795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L26_RS11800	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L26_RS11815	COG0583	DNA-binding transcription factor activity
I6L26_RS11830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L26_RS11840	COG3658	cytochrome
I6L26_RS11845	COG1215	transferase activity, transferring glycosyl groups
I6L26_RS11850	COG0726	polysaccharide deacetylase
I6L26_RS11850	COG1649	PFAM Uncharacterised BCR, COG1649
I6L26_RS11880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L26_RS11885	COG1845	cytochrome c oxidase, subunit III
I6L26_RS11890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L26_RS11915	COG0305	Participates in initiation and elongation during chromosome replication
I6L26_RS11920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L26_RS11930	COG1305	Transglutaminase-like
I6L26_RS11940	COG2308	Evidence 4 Homologs of previously reported genes of
I6L26_RS11970	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L26_RS11980	COG0151	Belongs to the GarS family
I6L26_RS11990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L26_RS11995	COG2011	ABC-type metal ion transport system permease component
I6L26_RS12000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L26_RS12010	COG1301	dicarboxylic acid transport
I6L26_RS12040	COG1794	racemase activity, acting on amino acids and derivatives
I6L26_RS12055	COG0745	RESPONSE REGULATOR receiver
I6L26_RS12060	COG0642	Histidine kinase
I6L26_RS12065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L26_RS12075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L26_RS12115	COG2351	hydroxyisourate hydrolase activity
I6L26_RS12125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L26_RS12125	COG3008	intermembrane lipid transfer
I6L26_RS12130	COG2995	paraquat-inducible protein a
I6L26_RS12145	COG2985	domain, Protein
I6L26_RS12155	COG1309	transcriptional regulator
I6L26_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS12210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L26_RS12210	COG0475	glutathione-regulated potassium exporter activity
I6L26_RS12215	COG0786	glutamate:sodium symporter activity
I6L26_RS12220	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6L26_RS12235	COG1278	Cold shock
I6L26_RS12290	COG1610	YqeY-like protein
I6L26_RS12295	COG4783	chaperone-mediated protein folding
I6L26_RS12320	COG1286	toxin biosynthetic process
I6L26_RS12350	COG0778	Nitroreductase
I6L26_RS12360	COG0513	Belongs to the DEAD box helicase family
I6L26_RS12380	COG2363	Small membrane protein
I6L26_RS12410	COG4650	regulator
I6L26_RS12415	COG1234	tRNA 3'-trailer cleavage
I6L26_RS12420	COG1690	Belongs to the RtcB family
I6L26_RS12440	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L26_RS12445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L26_RS12455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L26_RS12470	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS12475	COG1301	dicarboxylic acid transport
I6L26_RS12480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L26_RS12485	COG3139	Protein of unknown function (DUF1315)
I6L26_RS12490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L26_RS12495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L26_RS12505	COG0494	nUDIX hydrolase
I6L26_RS12515	COG0642	Histidine kinase
I6L26_RS12530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L26_RS12540	COG1720	tRNA m6t6A37 methyltransferase activity
I6L26_RS12550	COG0384	phenazine biosynthesis protein PhzF
I6L26_RS12555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L26_RS12560	COG0826	peptidase U32
I6L26_RS12565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L26_RS12575	COG4598	ABC transporter
I6L26_RS12580	COG4160	amino acid transport
I6L26_RS12585	COG4215	(ABC) transporter
I6L26_RS12590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L26_RS12600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L26_RS12645	COG1131	(ABC) transporter
I6L26_RS12650	COG0842	Transport permease protein
I6L26_RS12665	COG0772	Belongs to the SEDS family
I6L26_RS12670	COG2951	lytic endotransglycosylase activity
I6L26_RS12710	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L26_RS12715	COG0024	Methionine aminopeptidase
I6L26_RS12725	COG2223	nitrite transmembrane transporter activity
I6L26_RS12735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L26_RS12740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L26_RS12745	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS12760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L26_RS12765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L26_RS12770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L26_RS12790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L26_RS12795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L26_RS12800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L26_RS12835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L26_RS12845	COG0174	glutamine synthetase
I6L26_RS12860	COG0582	viral genome integration into host DNA
I6L26_RS12880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L26_RS12950	COG1196	nuclear chromosome segregation
I6L26_RS12950	COG0741	lytic transglycosylase activity
I6L26_RS12950	COG0739	heme binding
I6L26_RS12960	COG1598	PFAM Uncharacterised protein family UPF0150
I6L26_RS13195	COG3530	Putative quorum-sensing-regulated virulence factor
I6L26_RS13235	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L26_RS13270	COG2840	Smr protein MutS2
I6L26_RS13280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L26_RS13290	COG0302	gtp cyclohydrolase
I6L26_RS13340	COG1169	isochorismate synthase
I6L26_RS13345	COG2977	Belongs to the P-Pant transferase superfamily
I6L26_RS13350	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6L26_RS13355	COG1132	(ABC) transporter
I6L26_RS13360	COG1132	(ABC) transporter
I6L26_RS13370	COG3433	isochorismatase activity
I6L26_RS13370	COG1535	isochorismatase
I6L26_RS13375	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L26_RS13380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L26_RS13390	COG4774	siderophore transport
I6L26_RS13395	COG4607	ABC-type enterochelin transport system periplasmic component
I6L26_RS13400	COG4604	ABC transporter, ATP-binding protein
I6L26_RS13405	COG4605	iron ion homeostasis
I6L26_RS13410	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L26_RS13415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L26_RS13430	COG1741	Belongs to the pirin family
I6L26_RS13465	COG2879	small protein
I6L26_RS13470	COG1966	Carbon starvation protein
I6L26_RS13475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L26_RS13515	COG1067	ATP-dependent peptidase activity
I6L26_RS13520	COG0583	DNA-binding transcription factor activity
I6L26_RS13545	COG1686	Belongs to the peptidase S11 family
I6L26_RS13550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L26_RS13585	COG0616	signal peptide processing
I6L26_RS13590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L26_RS13600	COG0573	inorganic phosphate transmembrane transporter activity
I6L26_RS13605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L26_RS13610	COG1113	amino acid transport
I6L26_RS13615	COG3961	Belongs to the TPP enzyme family
I6L26_RS13620	COG1522	sequence-specific DNA binding
I6L26_RS13630	COG0076	glutamate decarboxylase activity
I6L26_RS13635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L26_RS13650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L26_RS13685	COG0352	thiamine-phosphate diphosphorylase activity
I6L26_RS13710	COG0612	Peptidase, M16
I6L26_RS13720	COG1823	symporter activity
I6L26_RS13725	COG0583	DNA-binding transcription factor activity
I6L26_RS13730	COG0477	Major facilitator Superfamily
I6L26_RS13745	COG1187	pseudouridine synthase activity
I6L26_RS13760	COG1686	Belongs to the peptidase S11 family
I6L26_RS13765	COG1252	NADH dehydrogenase
I6L26_RS13775	COG0415	Belongs to the DNA photolyase family
I6L26_RS13790	COG1215	transferase activity, transferring glycosyl groups
I6L26_RS13805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L26_RS13820	COG2070	2-Nitropropane dioxygenase
I6L26_RS13865	COG2962	Rard protein
I6L26_RS13875	COG0556	nucleotide-excision repair
I6L26_RS13895	COG0436	Aminotransferase
I6L26_RS13925	COG4221	oxidoreductase activity
I6L26_RS13935	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L26_RS13950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L26_RS13955	COG0571	ribonuclease III activity
I6L26_RS13965	COG0681	Belongs to the peptidase S26 family
I6L26_RS13970	COG0481	GTPase activity
I6L26_RS13980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L26_RS14000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L26_RS14005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L26_RS14010	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L26_RS14020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L26_RS14025	COG4208	sulfate ABC transporter
I6L26_RS14030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L26_RS14035	COG0583	DNA-binding transcription factor activity
I6L26_RS14040	COG4625	pathogenesis
I6L26_RS14055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L26_RS14070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L26_RS14085	COG1051	belongs to the nudix hydrolase family
I6L26_RS14085	COG1056	cytidyltransferase-related domain
I6L26_RS14090	COG1024	Enoyl-CoA hydratase
I6L26_RS14095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L26_RS14100	COG2814	Major facilitator Superfamily
I6L26_RS14105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L26_RS14105	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L26_RS14125	COG1473	amidohydrolase
I6L26_RS14130	COG0824	Thioesterase
I6L26_RS14150	COG0823	Involved in the tonB-independent uptake of proteins
I6L26_RS14170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L26_RS14205	COG0628	permease
I6L26_RS14215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L26_RS14220	COG0596	Alpha beta hydrolase
I6L26_RS14225	COG0616	signal peptide processing
I6L26_RS14225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L26_RS14235	COG0658	competence protein
I6L26_RS14235	COG2333	competence protein COMEC
I6L26_RS14240	COG1136	(ABC) transporter
I6L26_RS14245	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L26_RS14275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L26_RS14305	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L26_RS14310	COG1280	lysine exporter protein (LysE YggA)
I6L26_RS14320	COG0019	diaminopimelate decarboxylase activity
I6L26_RS14330	COG1113	amino acid transport
I6L26_RS14335	COG1115	amino acid carrier protein
I6L26_RS14360	COG3339	Conserved Protein
I6L26_RS14365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L26_RS14370	COG0243	molybdopterin cofactor binding
I6L26_RS14375	COG1929	Belongs to the glycerate kinase type-1 family
I6L26_RS14390	COG0778	Nitroreductase
I6L26_RS14395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L26_RS14400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L26_RS14435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L26_RS14455	COG0741	lytic transglycosylase activity
I6L26_RS14475	COG0584	glycerophosphoryl diester phosphodiesterase
I6L26_RS14480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L26_RS14505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L26_RS14510	COG1597	lipid kinase activity
I6L26_RS14525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L26_RS14530	COG0477	Major facilitator Superfamily
I6L26_RS14540	COG2264	protein methyltransferase activity
I6L26_RS14580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L26_RS14585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L26_RS14615	COG0505	Belongs to the CarA family
I6L26_RS14635	COG0251	oxidation-reduction process
I6L26_RS14645	COG0589	response to stress
I6L26_RS14665	COG2843	Capsule synthesis protein
I6L26_RS14685	COG2321	neutral zinc metallopeptidase
I6L26_RS14690	COG2354	Protein conserved in bacteria
I6L26_RS14710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L26_RS14735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L26_RS14740	COG1053	succinate dehydrogenase
I6L26_RS14745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L26_RS14750	COG2009	succinate dehydrogenase
I6L26_RS14790	COG2921	Belongs to the UPF0250 family
I6L26_RS14795	COG0321	lipoyl(octanoyl) transferase activity
I6L26_RS14810	COG0531	amino acid
I6L26_RS14845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L26_RS14850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L26_RS14850	COG1648	precorrin-2 dehydrogenase activity
I6L26_RS14865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L26_RS14890	COG0671	phosphoesterase, PA-phosphatase related
I6L26_RS14895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L26_RS14905	COG1538	Outer membrane efflux protein
I6L26_RS14910	COG0393	Putative heavy-metal-binding
I6L26_RS14915	COG0393	Putative heavy-metal-binding
I6L26_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
I6L26_RS14935	COG0525	valine-tRNA ligase activity
I6L26_RS14960	COG0583	DNA-binding transcription factor activity
I6L26_RS14965	COG0004	ammonium transporteR
I6L26_RS14980	COG0642	Histidine kinase
I6L26_RS14985	COG0745	RESPONSE REGULATOR receiver
I6L26_RS14990	COG2194	sulfuric ester hydrolase activity
I6L26_RS15015	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L26_RS15030	COG2315	Protein conserved in bacteria
I6L26_RS15035	COG0142	geranyltranstransferase activity
I6L26_RS15040	COG2828	Protein conserved in bacteria
I6L26_RS15045	COG1113	amino acid transport
I6L26_RS15055	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L26_RS15085	COG2207	Transcriptional regulator
I6L26_RS15110	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L26_RS15130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L26_RS15140	COG1530	ribonuclease E activity
I6L26_RS15145	COG0424	maF-like protein
I6L26_RS15150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L26_RS15155	COG1792	Involved in formation and maintenance of cell shape
I6L26_RS15160	COG1077	Cell shape determining protein MreB Mrl
I6L26_RS15165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L26_RS15175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L26_RS15200	COG3590	peptidase
I6L26_RS15205	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L26_RS15210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L26_RS15215	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L26_RS15220	COG1115	amino acid carrier protein
I6L26_RS15240	COG2814	Major facilitator Superfamily
I6L26_RS15245	COG1289	transmembrane transporter activity
I6L26_RS15255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L26_RS15295	COG1376	ErfK ybiS ycfS ynhG family protein
I6L26_RS15300	COG2832	Protein of unknown function (DUF454)
I6L26_RS15310	COG5510	response to toxic substance
I6L26_RS15330	COG0840	transmembrane signaling receptor activity
I6L26_RS15370	COG3422	double-strand break repair
I6L26_RS15375	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L26_RS15380	COG3189	MarR family transcriptional regulator
I6L26_RS15385	COG0596	Alpha beta hydrolase
I6L26_RS15390	COG0778	Nitroreductase
I6L26_RS15395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L26_RS15400	COG1335	isochorismatase
I6L26_RS15405	COG0251	oxidation-reduction process
I6L26_RS15410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L26_RS15415	COG2233	PERMEase
I6L26_RS15435	COG0354	folic acid binding
I6L26_RS15440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L26_RS15450	COG0679	Auxin Efflux Carrier
I6L26_RS15455	COG1902	pentaerythritol trinitrate reductase activity
I6L26_RS15460	COG4772	TonB-dependent receptor
I6L26_RS15465	COG2094	Belongs to the DNA glycosylase MPG family
I6L26_RS15490	COG1217	gtp-binding protein TYPA
I6L26_RS15495	COG2233	PERMEase
I6L26_RS15505	COG0833	amino acid
I6L26_RS15510	COG1690	Belongs to the RtcB family
I6L26_RS15520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L26_RS15520	COG2885	chlorophyll binding
I6L26_RS15530	COG0183	Belongs to the thiolase family
I6L26_RS15550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L26_RS15570	COG2207	Transcriptional regulator
I6L26_RS15575	COG0183	Belongs to the thiolase family
I6L26_RS15595	COG2153	protein acetylation
I6L26_RS15605	COG1272	protein, Hemolysin III
I6L26_RS15610	COG0477	Major facilitator Superfamily
I6L26_RS15625	COG0450	alkyl hydroperoxide reductase
I6L26_RS15645	COG0285	dihydrofolate synthase activity
I6L26_RS15690	COG4206	TonB-dependent receptor
I6L26_RS15695	COG2096	Adenosyltransferase
I6L26_RS15715	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L26_RS15725	COG0745	RESPONSE REGULATOR receiver
I6L26_RS15730	COG2205	protein histidine kinase activity
I6L26_RS15740	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS15745	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS15750	COG0583	DNA-binding transcription factor activity
I6L26_RS15755	COG0625	glutathione transferase activity
I6L26_RS15805	COG1216	Glycosyl transferase, family 2
I6L26_RS15820	COG0726	polysaccharide deacetylase
I6L26_RS15835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L26_RS15840	COG0784	Response regulator, receiver
I6L26_RS15840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L26_RS15840	COG2198	Histidine kinase
I6L26_RS15840	COG2205	protein histidine kinase activity
I6L26_RS15860	COG1862	Preprotein translocase
I6L26_RS15870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L26_RS15875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L26_RS15885	COG3781	membrane
I6L26_RS15900	COG2350	Protein conserved in bacteria
I6L26_RS15935	COG1607	acyl-coa hydrolase
I6L26_RS15960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L26_RS16005	COG2199	diguanylate cyclase activity
I6L26_RS16010	COG2885	chlorophyll binding
I6L26_RS16010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L26_RS16015	COG1408	metallophosphoesterase
I6L26_RS16020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L26_RS16030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L26_RS16050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L26_RS16055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L26_RS16060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L26_RS16065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L26_RS16070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L26_RS16080	COG2969	positive regulation of protein catabolic process
I6L26_RS16120	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS16125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L26_RS16140	COG1309	transcriptional regulator
I6L26_RS16145	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS16190	COG1183	phosphatidylcholine synthase activity
I6L26_RS16195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L26_RS16225	COG0739	heme binding
I6L26_RS16225	COG0741	lytic transglycosylase activity
I6L26_RS16225	COG1196	nuclear chromosome segregation
I6L26_RS16235	COG1702	phosphate starvation-inducible protein PhoH
I6L26_RS16270	COG1295	ribonuclease BN
I6L26_RS16275	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L26_RS16325	COG0557	exoribonuclease II activity
I6L26_RS16330	COG0339	signal peptide processing
I6L26_RS16335	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L26_RS16365	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L26_RS16370	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS16505	COG0088	Forms part of the polypeptide exit tunnel
I6L26_RS16510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L26_RS16525	COG0626	cystathionine gamma-synthase activity
I6L26_RS16530	COG0433	COG0433 Predicted ATPase
I6L26_RS16540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L26_RS16540	COG1017	nitric oxide dioxygenase activity
I6L26_RS16545	COG1959	2 iron, 2 sulfur cluster binding
I6L26_RS16560	COG1301	dicarboxylic acid transport
I6L26_RS16565	COG1946	Acyl-CoA thioesterase
I6L26_RS16585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L26_RS16590	COG1040	competence protein
I6L26_RS16595	COG0494	nUDIX hydrolase
I6L26_RS16605	COG0598	Magnesium transport protein CorA
I6L26_RS16615	COG2854	intermembrane phospholipid transfer
I6L26_RS16625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L26_RS16630	COG1127	ABC transporter
I6L26_RS16640	COG0513	Belongs to the DEAD box helicase family
I6L26_RS16660	COG0408	coproporphyrinogen oxidase activity
I6L26_RS16675	COG1960	acyl-CoA dehydrogenase activity
I6L26_RS16685	COG1983	PspC domain protein
I6L26_RS16690	COG0517	IMP dehydrogenase activity
I6L26_RS16710	COG0752	glycyl-tRNA synthetase alpha subunit
I6L26_RS16735	COG0583	DNA-binding transcription factor activity
I6L26_RS16775	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS16785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L26_RS16790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L26_RS16795	COG0833	amino acid
I6L26_RS16825	COG1192	Involved in chromosome partitioning
I6L26_RS16830	COG0628	permease
I6L26_RS16840	COG1289	transmembrane transporter activity
I6L26_RS16855	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L26_RS16860	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L26_RS16880	COG0277	FAD linked oxidase domain protein
I6L26_RS16885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L26_RS16890	COG5006	permease, DMT superfamily
I6L26_RS16910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L26_RS16915	COG5380	lipid catabolic process
I6L26_RS16925	COG0335	large ribosomal subunit rRNA binding
I6L26_RS16935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L26_RS16985	COG0194	GDP metabolic process
I6L26_RS17000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L26_RS17025	COG3307	-O-antigen
I6L26_RS17045	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L26_RS17050	COG1704	LemA family
I6L26_RS17060	COG0493	'glutamate synthase
I6L26_RS17065	COG0069	glutamate synthase activity
I6L26_RS17065	COG0067	glutamate synthase
I6L26_RS17065	COG0070	glutamate synthase
I6L26_RS17115	COG2226	methyltransferase
I6L26_RS17130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L26_RS17135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L26_RS17180	COG0833	amino acid
I6L26_RS17260	COG0488	(ABC) transporter
I6L26_RS17265	COG2873	o-acetylhomoserine
I6L26_RS17270	COG4221	oxidoreductase activity
I6L26_RS17275	COG0659	secondary active sulfate transmembrane transporter activity
I6L26_RS17300	COG0427	acetyl-CoA hydrolase
I6L26_RS17330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L26_RS17340	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L26_RS17360	COG2329	Antibiotic biosynthesis monooxygenase
I6L26_RS17375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L26_RS17435	COG2207	Transcriptional regulator
I6L26_RS17440	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L26_RS17450	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L26_RS17455	COG1733	regulation of RNA biosynthetic process
I6L26_RS17470	COG1309	transcriptional regulator
I6L26_RS17485	COG0667	Aldo Keto reductase
I6L26_RS17505	COG0583	DNA-binding transcription factor activity
I6L26_RS17510	COG2814	Major facilitator Superfamily
I6L26_RS17550	COG1335	isochorismatase
I6L26_RS17560	COG1012	belongs to the aldehyde dehydrogenase family
I6L26_RS17565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L26_RS17585	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L26_RS17600	COG2814	Major facilitator Superfamily
I6L26_RS17610	COG0352	thiamine-phosphate diphosphorylase activity
I6L26_RS17610	COG0351	phosphomethylpyrimidine kinase
I6L26_RS17610	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L26_RS17630	COG1309	transcriptional regulator
I6L26_RS17650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L26_RS17660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L26_RS17665	COG3162	membrane
I6L26_RS17670	COG0784	Response regulator, receiver
I6L26_RS17670	COG2205	protein histidine kinase activity
I6L26_RS17670	COG2198	Histidine kinase
I6L26_RS17695	COG1522	sequence-specific DNA binding
I6L26_RS17700	COG1335	isochorismatase
I6L26_RS17705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L26_RS17715	COG0668	transmembrane transport
I6L26_RS17725	COG1519	Transferase
I6L26_RS17730	COG1902	pentaerythritol trinitrate reductase activity
I6L26_RS17750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L26_RS17770	COG0426	domain, Protein
I6L26_RS17770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L26_RS17775	COG4774	siderophore transport
I6L26_RS17780	COG2119	membrane
I6L26_RS17790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L26_RS17800	COG4942	peptidase
I6L26_RS17815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L26_RS17825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L26_RS17845	COG0189	ligase activity
I6L26_RS17865	COG0708	Exodeoxyribonuclease III
I6L26_RS17870	COG1393	Belongs to the ArsC family
I6L26_RS17885	COG3706	GGDEF domain
I6L26_RS17920	COG2351	hydroxyisourate hydrolase activity
I6L26_RS17925	COG2233	PERMEase
I6L26_RS17935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L26_RS17945	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6L26_RS17955	COG3150	esterase
I6L26_RS17990	COG0604	alcohol dehydrogenase
I6L26_RS18015	COG0582	viral genome integration into host DNA
I6L26_RS18030	COG2130	NADP-dependent
I6L26_RS18035	COG1309	transcriptional regulator
I6L26_RS18045	COG1902	pentaerythritol trinitrate reductase activity
I6L26_RS18055	COG1979	alcohol dehydrogenase
I6L26_RS18070	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L26_RS18100	COG0477	Major facilitator Superfamily
I6L26_RS18105	COG0697	spore germination
I6L26_RS18115	COG0604	alcohol dehydrogenase
I6L26_RS18115	COG3321	synthase
I6L26_RS18120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L26_RS18125	COG0583	DNA-binding transcription factor activity
I6L26_RS18130	COG4221	oxidoreductase activity
I6L26_RS18165	COG3077	Addiction module antitoxin, RelB DinJ family
I6L26_RS18180	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L26_RS18205	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L26_RS18235	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6L26_RS18235	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6L26_RS18285	COG2184	nucleotidyltransferase activity
I6L26_RS18320	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6L26_RS18425	COG1785	Belongs to the alkaline phosphatase family
I6L26_RS18430	COG1475	DNA binding
I6L26_RS18435	COG1192	Involved in chromosome partitioning
I6L26_RS18475	COG1063	alcohol dehydrogenase
I6L26_RS18550	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L26_RS18565	COG0592	DNA-directed DNA polymerase activity
I6L26_RS18575	COG1196	nuclear chromosome segregation
I6L26_RS18735	COG1538	Outer membrane efflux protein