locus-tag	class	description
I6L29_RS00040	COG1702	phosphate starvation-inducible protein PhoH
I6L29_RS00050	COG0739	heme binding
I6L29_RS00050	COG0741	lytic transglycosylase activity
I6L29_RS00050	COG1196	nuclear chromosome segregation
I6L29_RS00080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L29_RS00085	COG1183	phosphatidylcholine synthase activity
I6L29_RS00130	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS00135	COG1309	transcriptional regulator
I6L29_RS00150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L29_RS00155	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS00195	COG2969	positive regulation of protein catabolic process
I6L29_RS00205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L29_RS00210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L29_RS00215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L29_RS00220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L29_RS00225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L29_RS00245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L29_RS00255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L29_RS00260	COG1408	metallophosphoesterase
I6L29_RS00265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L29_RS00265	COG2885	chlorophyll binding
I6L29_RS00270	COG2199	diguanylate cyclase activity
I6L29_RS00340	COG1607	acyl-coa hydrolase
I6L29_RS00375	COG2350	Protein conserved in bacteria
I6L29_RS00390	COG3781	membrane
I6L29_RS00400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L29_RS00405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L29_RS00415	COG1862	Preprotein translocase
I6L29_RS00455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L29_RS00470	COG0726	polysaccharide deacetylase
I6L29_RS00485	COG1216	Glycosyl transferase, family 2
I6L29_RS00535	COG0625	glutathione transferase activity
I6L29_RS00540	COG0583	DNA-binding transcription factor activity
I6L29_RS00545	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS00550	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS00560	COG2205	protein histidine kinase activity
I6L29_RS00565	COG0745	RESPONSE REGULATOR receiver
I6L29_RS00575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L29_RS00595	COG2096	Adenosyltransferase
I6L29_RS00600	COG4206	TonB-dependent receptor
I6L29_RS00645	COG0285	dihydrofolate synthase activity
I6L29_RS00665	COG0450	alkyl hydroperoxide reductase
I6L29_RS00680	COG0477	Major facilitator Superfamily
I6L29_RS00685	COG1272	protein, Hemolysin III
I6L29_RS00695	COG2153	protein acetylation
I6L29_RS00715	COG0183	Belongs to the thiolase family
I6L29_RS00720	COG2207	Transcriptional regulator
I6L29_RS00740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_RS00760	COG0183	Belongs to the thiolase family
I6L29_RS00770	COG2885	chlorophyll binding
I6L29_RS00770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L29_RS00780	COG1690	Belongs to the RtcB family
I6L29_RS00785	COG0833	amino acid
I6L29_RS00795	COG2233	PERMEase
I6L29_RS00800	COG1217	gtp-binding protein TYPA
I6L29_RS00825	COG2094	Belongs to the DNA glycosylase MPG family
I6L29_RS00830	COG4772	TonB-dependent receptor
I6L29_RS00835	COG1902	pentaerythritol trinitrate reductase activity
I6L29_RS00850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L29_RS00855	COG0354	folic acid binding
I6L29_RS00875	COG2233	PERMEase
I6L29_RS00880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_RS00885	COG0251	oxidation-reduction process
I6L29_RS00890	COG1335	isochorismatase
I6L29_RS00895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_RS00905	COG0596	Alpha beta hydrolase
I6L29_RS00910	COG3189	MarR family transcriptional regulator
I6L29_RS00915	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L29_RS00920	COG3422	double-strand break repair
I6L29_RS00960	COG0840	transmembrane signaling receptor activity
I6L29_RS00980	COG5510	response to toxic substance
I6L29_RS00990	COG2832	Protein of unknown function (DUF454)
I6L29_RS00995	COG1376	ErfK ybiS ycfS ynhG family protein
I6L29_RS01035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L29_RS01045	COG1289	transmembrane transporter activity
I6L29_RS01050	COG2814	Major facilitator Superfamily
I6L29_RS01070	COG1115	amino acid carrier protein
I6L29_RS01075	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L29_RS01080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L29_RS01085	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L29_RS01090	COG3590	peptidase
I6L29_RS01100	COG5342	invasion associated locus B
I6L29_RS01115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L29_RS01125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L29_RS01130	COG1077	Cell shape determining protein MreB Mrl
I6L29_RS01135	COG1792	Involved in formation and maintenance of cell shape
I6L29_RS01140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L29_RS01145	COG0424	maF-like protein
I6L29_RS01150	COG1530	ribonuclease E activity
I6L29_RS01160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L29_RS01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L29_RS01205	COG2207	Transcriptional regulator
I6L29_RS01235	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L29_RS01245	COG1113	amino acid transport
I6L29_RS01250	COG2828	Protein conserved in bacteria
I6L29_RS01255	COG0142	geranyltranstransferase activity
I6L29_RS01260	COG2315	Protein conserved in bacteria
I6L29_RS01275	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L29_RS01300	COG2194	sulfuric ester hydrolase activity
I6L29_RS01305	COG0745	RESPONSE REGULATOR receiver
I6L29_RS01310	COG0642	Histidine kinase
I6L29_RS01325	COG0004	ammonium transporteR
I6L29_RS01330	COG0583	DNA-binding transcription factor activity
I6L29_RS01350	COG0525	valine-tRNA ligase activity
I6L29_RS01360	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS01370	COG0393	Putative heavy-metal-binding
I6L29_RS01375	COG0393	Putative heavy-metal-binding
I6L29_RS01380	COG1538	Outer membrane efflux protein
I6L29_RS01390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_RS01395	COG0671	phosphoesterase, PA-phosphatase related
I6L29_RS01420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L29_RS01435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L29_RS01435	COG1648	precorrin-2 dehydrogenase activity
I6L29_RS01440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L29_RS01475	COG0531	amino acid
I6L29_RS01490	COG0321	lipoyl(octanoyl) transferase activity
I6L29_RS01495	COG2921	Belongs to the UPF0250 family
I6L29_RS01535	COG2009	succinate dehydrogenase
I6L29_RS01540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L29_RS01545	COG1053	succinate dehydrogenase
I6L29_RS01550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L29_RS01575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L29_RS01595	COG2354	Protein conserved in bacteria
I6L29_RS01600	COG2321	neutral zinc metallopeptidase
I6L29_RS01620	COG2843	Capsule synthesis protein
I6L29_RS01640	COG0589	response to stress
I6L29_RS01650	COG0251	oxidation-reduction process
I6L29_RS01670	COG0505	Belongs to the CarA family
I6L29_RS01700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L29_RS01705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L29_RS01745	COG2264	protein methyltransferase activity
I6L29_RS01755	COG0477	Major facilitator Superfamily
I6L29_RS01760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L29_RS01775	COG1597	lipid kinase activity
I6L29_RS01780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L29_RS01805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L29_RS01810	COG0584	glycerophosphoryl diester phosphodiesterase
I6L29_RS01830	COG0741	lytic transglycosylase activity
I6L29_RS01850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L29_RS01855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L29_RS01885	COG1309	transcriptional regulator
I6L29_RS01890	COG1902	pentaerythritol trinitrate reductase activity
I6L29_RS01895	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_RS01895	COG0596	Alpha beta hydrolase
I6L29_RS01900	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_RS01900	COG0596	Alpha beta hydrolase
I6L29_RS01905	COG0596	Alpha beta hydrolase
I6L29_RS01910	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS01920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_RS01930	COG0778	Nitroreductase
I6L29_RS01945	COG1929	Belongs to the glycerate kinase type-1 family
I6L29_RS01950	COG0243	molybdopterin cofactor binding
I6L29_RS01955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L29_RS01970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6L29_RS01985	COG1115	amino acid carrier protein
I6L29_RS01990	COG1113	amino acid transport
I6L29_RS02000	COG0019	diaminopimelate decarboxylase activity
I6L29_RS02010	COG1280	lysine exporter protein (LysE YggA)
I6L29_RS02015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L29_RS02045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_RS02075	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L29_RS02080	COG1136	(ABC) transporter
I6L29_RS02085	COG0658	competence protein
I6L29_RS02085	COG2333	competence protein COMEC
I6L29_RS02095	COG0616	signal peptide processing
I6L29_RS02095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L29_RS02100	COG0596	Alpha beta hydrolase
I6L29_RS02105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L29_RS02115	COG0628	permease
I6L29_RS02150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L29_RS02170	COG0823	Involved in the tonB-independent uptake of proteins
I6L29_RS02190	COG0824	Thioesterase
I6L29_RS02195	COG1473	amidohydrolase
I6L29_RS02215	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L29_RS02215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L29_RS02220	COG2814	Major facilitator Superfamily
I6L29_RS02225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L29_RS02230	COG1024	Enoyl-CoA hydratase
I6L29_RS02235	COG1056	cytidyltransferase-related domain
I6L29_RS02235	COG1051	belongs to the nudix hydrolase family
I6L29_RS02250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L29_RS02265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L29_RS02280	COG4625	pathogenesis
I6L29_RS02285	COG0583	DNA-binding transcription factor activity
I6L29_RS02290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L29_RS02295	COG4208	sulfate ABC transporter
I6L29_RS02300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L29_RS02310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L29_RS02315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L29_RS02320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L29_RS02340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L29_RS02350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L29_RS02355	COG0481	GTPase activity
I6L29_RS02360	COG0681	Belongs to the peptidase S26 family
I6L29_RS02370	COG0571	ribonuclease III activity
I6L29_RS02375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L29_RS02385	COG1381	Involved in DNA repair and RecF pathway recombination
I6L29_RS02390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L29_RS02400	COG4221	oxidoreductase activity
I6L29_RS02430	COG0436	Aminotransferase
I6L29_RS02450	COG0556	nucleotide-excision repair
I6L29_RS02460	COG2962	Rard protein
I6L29_RS02505	COG2070	2-Nitropropane dioxygenase
I6L29_RS02520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L29_RS02535	COG1215	transferase activity, transferring glycosyl groups
I6L29_RS02550	COG0415	Belongs to the DNA photolyase family
I6L29_RS02560	COG1252	NADH dehydrogenase
I6L29_RS02565	COG1686	Belongs to the peptidase S11 family
I6L29_RS02580	COG1187	pseudouridine synthase activity
I6L29_RS02595	COG0477	Major facilitator Superfamily
I6L29_RS02600	COG0583	DNA-binding transcription factor activity
I6L29_RS02605	COG1823	symporter activity
I6L29_RS02615	COG0612	Peptidase, M16
I6L29_RS02640	COG0352	thiamine-phosphate diphosphorylase activity
I6L29_RS02675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_RS02690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L29_RS02695	COG0076	glutamate decarboxylase activity
I6L29_RS02705	COG1522	sequence-specific DNA binding
I6L29_RS02710	COG3961	Belongs to the TPP enzyme family
I6L29_RS02715	COG1113	amino acid transport
I6L29_RS02720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L29_RS02725	COG0573	inorganic phosphate transmembrane transporter activity
I6L29_RS02735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L29_RS02740	COG0616	signal peptide processing
I6L29_RS02780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L29_RS02785	COG1686	Belongs to the peptidase S11 family
I6L29_RS02810	COG0583	DNA-binding transcription factor activity
I6L29_RS02815	COG1067	ATP-dependent peptidase activity
I6L29_RS02820	COG2211	Major facilitator Superfamily
I6L29_RS02855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L29_RS02860	COG1966	Carbon starvation protein
I6L29_RS02865	COG2879	small protein
I6L29_RS02895	COG1741	Belongs to the pirin family
I6L29_RS02910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L29_RS02915	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L29_RS02920	COG4605	iron ion homeostasis
I6L29_RS02925	COG4604	ABC transporter, ATP-binding protein
I6L29_RS02930	COG4607	ABC-type enterochelin transport system periplasmic component
I6L29_RS02935	COG4774	siderophore transport
I6L29_RS02945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L29_RS02950	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L29_RS02955	COG3433	isochorismatase activity
I6L29_RS02955	COG1535	isochorismatase
I6L29_RS02970	COG1132	(ABC) transporter
I6L29_RS02975	COG1132	(ABC) transporter
I6L29_RS02980	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6L29_RS02985	COG2977	Belongs to the P-Pant transferase superfamily
I6L29_RS02990	COG1169	isochorismate synthase
I6L29_RS03005	COG3739	integral membrane protein
I6L29_RS03025	COG0302	gtp cyclohydrolase
I6L29_RS03035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L29_RS03045	COG2840	Smr protein MutS2
I6L29_RS03070	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L29_RS03085	COG0174	glutamine synthetase
I6L29_RS03095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L29_RS03130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L29_RS03135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L29_RS03140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L29_RS03160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L29_RS03165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L29_RS03170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L29_RS03185	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS03190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L29_RS03195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L29_RS03205	COG2223	nitrite transmembrane transporter activity
I6L29_RS03215	COG0024	Methionine aminopeptidase
I6L29_RS03220	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L29_RS03235	COG2207	Transcriptional regulator
I6L29_RS03260	COG2951	lytic endotransglycosylase activity
I6L29_RS03265	COG0772	Belongs to the SEDS family
I6L29_RS03280	COG0842	Transport permease protein
I6L29_RS03285	COG1131	(ABC) transporter
I6L29_RS03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_RS03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L29_RS03345	COG4215	(ABC) transporter
I6L29_RS03350	COG4160	amino acid transport
I6L29_RS03355	COG4598	ABC transporter
I6L29_RS03365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L29_RS03370	COG0826	peptidase U32
I6L29_RS03375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_RS03380	COG0384	phenazine biosynthesis protein PhzF
I6L29_RS03390	COG1720	tRNA m6t6A37 methyltransferase activity
I6L29_RS03400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L29_RS03415	COG0642	Histidine kinase
I6L29_RS03425	COG0494	nUDIX hydrolase
I6L29_RS03435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L29_RS03440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L29_RS03445	COG3139	Protein of unknown function (DUF1315)
I6L29_RS03450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L29_RS03455	COG1301	dicarboxylic acid transport
I6L29_RS03460	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS03480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L29_RS03490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L29_RS03495	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L29_RS03515	COG1690	Belongs to the RtcB family
I6L29_RS03520	COG1234	tRNA 3'-trailer cleavage
I6L29_RS03525	COG4650	regulator
I6L29_RS03555	COG2363	Small membrane protein
I6L29_RS03575	COG0513	Belongs to the DEAD box helicase family
I6L29_RS03585	COG0778	Nitroreductase
I6L29_RS03615	COG1286	toxin biosynthetic process
I6L29_RS03640	COG4783	chaperone-mediated protein folding
I6L29_RS03645	COG1610	YqeY-like protein
I6L29_RS03675	COG0515	serine threonine protein kinase
I6L29_RS03675	COG2815	serine threonine protein kinase
I6L29_RS03700	COG1278	Cold shock
I6L29_RS03715	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6L29_RS03720	COG0786	glutamate:sodium symporter activity
I6L29_RS03725	COG0475	glutathione-regulated potassium exporter activity
I6L29_RS03725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L29_RS03740	COG1309	transcriptional regulator
I6L29_RS03750	COG2985	domain, Protein
I6L29_RS03760	COG2995	paraquat-inducible protein a
I6L29_RS03765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L29_RS03765	COG3008	intermembrane lipid transfer
I6L29_RS03775	COG2351	hydroxyisourate hydrolase activity
I6L29_RS03815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L29_RS03825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L29_RS03830	COG0642	Histidine kinase
I6L29_RS03835	COG0745	RESPONSE REGULATOR receiver
I6L29_RS03850	COG1794	racemase activity, acting on amino acids and derivatives
I6L29_RS03880	COG1301	dicarboxylic acid transport
I6L29_RS03890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L29_RS03895	COG2011	ABC-type metal ion transport system permease component
I6L29_RS03900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L29_RS03910	COG0151	Belongs to the GarS family
I6L29_RS03920	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L29_RS03950	COG2308	Evidence 4 Homologs of previously reported genes of
I6L29_RS03960	COG1305	Transglutaminase-like
I6L29_RS03970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L29_RS03975	COG0305	Participates in initiation and elongation during chromosome replication
I6L29_RS04000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L29_RS04005	COG1845	cytochrome c oxidase, subunit III
I6L29_RS04010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L29_RS04040	COG0726	polysaccharide deacetylase
I6L29_RS04040	COG1649	PFAM Uncharacterised BCR, COG1649
I6L29_RS04045	COG1215	transferase activity, transferring glycosyl groups
I6L29_RS04050	COG3658	cytochrome
I6L29_RS04060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_RS04075	COG0583	DNA-binding transcription factor activity
I6L29_RS04090	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L29_RS04095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_RS04100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_RS04115	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS04120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_RS04135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L29_RS04145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6L29_RS04150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6L29_RS04160	COG2205	protein histidine kinase activity
I6L29_RS04165	COG0745	RESPONSE REGULATOR receiver
I6L29_RS04170	COG0174	glutamine synthetase
I6L29_RS04190	COG0729	surface antigen
I6L29_RS04220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L29_RS04225	COG2814	Major facilitator Superfamily
I6L29_RS04235	COG0583	DNA-binding transcription factor activity
I6L29_RS04250	COG1187	pseudouridine synthase activity
I6L29_RS04270	COG0802	atpase or kinase
I6L29_RS04275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L29_RS04285	COG1923	regulation of RNA biosynthetic process
I6L29_RS04290	COG0697	spore germination
I6L29_RS04300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L29_RS04315	COG0519	Catalyzes the synthesis of GMP from XMP
I6L29_RS04315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L29_RS04320	COG4302	ethanolamine ammonia-lyase activity
I6L29_RS04325	COG4303	Ethanolamine ammonia lyase large subunit
I6L29_RS04330	COG0531	amino acid
I6L29_RS04350	COG1454	alcohol dehydrogenase
I6L29_RS04355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L29_RS04380	COG0308	aminopeptidase N
I6L29_RS04420	COG1605	Chorismate mutase
I6L29_RS04435	COG4772	TonB-dependent receptor
I6L29_RS04440	COG4774	siderophore transport
I6L29_RS04490	COG3772	lysozyme
I6L29_RS04515	COG0583	DNA-binding transcription factor activity
I6L29_RS04550	COG0488	(ABC) transporter
I6L29_RS04555	COG0589	response to stress
I6L29_RS04575	COG3135	benzoate transporter
I6L29_RS04580	COG1522	sequence-specific DNA binding
I6L29_RS04590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L29_RS04595	COG0583	DNA-binding transcription factor activity
I6L29_RS04605	COG0183	Belongs to the thiolase family
I6L29_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS04615	COG2030	dehydratase
I6L29_RS04620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L29_RS04645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L29_RS04660	COG0824	Thioesterase
I6L29_RS04665	COG1454	alcohol dehydrogenase
I6L29_RS04680	COG1335	isochorismatase
I6L29_RS04695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L29_RS04725	COG0069	glutamate synthase activity
I6L29_RS04750	COG2814	Major facilitator Superfamily
I6L29_RS04765	COG0511	ligase activity, forming carbon-carbon bonds
I6L29_RS04790	COG4264	IucA IucC family
I6L29_RS04800	COG4264	IucA IucC family
I6L29_RS04805	COG2423	ornithine cyclodeaminase activity
I6L29_RS04810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L29_RS04820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_RS04820	COG1116	anion transmembrane transporter activity
I6L29_RS04835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_RS04835	COG2146	nitrite reductase [NAD(P)H] activity
I6L29_RS04840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_RS04845	COG0243	molybdopterin cofactor binding
I6L29_RS04855	COG0243	molybdopterin cofactor binding
I6L29_RS04860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L29_RS04875	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L29_RS04875	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L29_RS04880	COG0303	'Molybdopterin
I6L29_RS04890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_RS04895	COG0697	spore germination
I6L29_RS04920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L29_RS04990	COG2204	response regulator
I6L29_RS04995	COG3852	Histidine kinase
I6L29_RS05020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L29_RS05025	COG0575	Belongs to the CDS family
I6L29_RS05060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L29_RS05075	COG2137	regulation of response to DNA damage stimulus
I6L29_RS05085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L29_RS05090	COG1011	Hydrolase
I6L29_RS05105	COG1522	sequence-specific DNA binding
I6L29_RS05115	COG1113	amino acid transport
I6L29_RS05120	COG0657	acetylesterase activity
I6L29_RS05135	COG0659	secondary active sulfate transmembrane transporter activity
I6L29_RS05170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L29_RS05170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L29_RS05170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L29_RS05175	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L29_RS05180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L29_RS05180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L29_RS05210	COG0024	Methionine aminopeptidase
I6L29_RS05215	COG0583	DNA-binding transcription factor activity
I6L29_RS05225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L29_RS05230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L29_RS05235	COG0517	IMP dehydrogenase activity
I6L29_RS05235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L29_RS05260	COG0552	protein localization to endoplasmic reticulum
I6L29_RS05285	COG4890	Cyd operon protein YbgT
I6L29_RS05290	COG1294	oxidase, subunit
I6L29_RS05305	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L29_RS05315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L29_RS05330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L29_RS05335	COG0569	domain protein
I6L29_RS05340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L29_RS05370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L29_RS05375	COG0542	response to heat
I6L29_RS05400	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L29_RS05400	COG1902	pentaerythritol trinitrate reductase activity
I6L29_RS05440	COG0148	phosphopyruvate hydratase activity
I6L29_RS05445	COG2323	membrane
I6L29_RS05455	COG4773	Receptor
I6L29_RS05460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L29_RS05470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L29_RS05475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L29_RS05480	COG0183	Belongs to the thiolase family
I6L29_RS05485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L29_RS05490	COG0596	Alpha beta hydrolase
I6L29_RS05495	COG2271	Major facilitator Superfamily
I6L29_RS05500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L29_RS05505	COG3485	protocatechuate 3,4-dioxygenase
I6L29_RS05510	COG3485	protocatechuate 3,4-dioxygenase
I6L29_RS05515	COG0710	3-dehydroquinate dehydratase activity
I6L29_RS05520	COG3420	alginic acid biosynthetic process
I6L29_RS05525	COG3659	wide pore channel activity
I6L29_RS05530	COG4993	Dehydrogenase
I6L29_RS05635	COG2369	cell adhesion
I6L29_RS05640	COG4383	Mu-like prophage protein gp29
I6L29_RS05660	COG4373	Mu-like prophage FluMu protein gp28
I6L29_RS05730	COG3267	Type II secretory pathway component ExeA
I6L29_RS05730	COG3409	Peptidoglycan-binding domain 1 protein
I6L29_RS05755	COG0776	regulation of translation
I6L29_RS05805	COG2391	methyltransferase activity
I6L29_RS05820	COG1414	Transcriptional regulator
I6L29_RS05825	COG0583	DNA-binding transcription factor activity
I6L29_RS05830	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS05855	COG2814	Major facilitator Superfamily
I6L29_RS05865	COG0154	amidase activity
I6L29_RS05895	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS05905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_RS05915	COG3733	amine oxidase
I6L29_RS05925	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS05930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L29_RS05935	COG0183	Belongs to the thiolase family
I6L29_RS05940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L29_RS05945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L29_RS05955	COG4829	muconolactone delta-isomerase
I6L29_RS05960	COG4948	Mandelate Racemase Muconate Lactonizing
I6L29_RS05965	COG0583	DNA-binding transcription factor activity
I6L29_RS05975	COG2186	Transcriptional regulator
I6L29_RS05995	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS06000	COG2351	hydroxyisourate hydrolase activity
I6L29_RS06005	COG2233	PERMEase
I6L29_RS06015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_RS06020	COG2186	Transcriptional regulator
I6L29_RS06030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_RS06040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_RS06060	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L29_RS06060	COG1902	pentaerythritol trinitrate reductase activity
I6L29_RS06100	COG1309	transcriptional regulator
I6L29_RS06105	COG0583	DNA-binding transcription factor activity
I6L29_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS06115	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS06130	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS06140	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_RS06215	COG0583	DNA-binding transcription factor activity
I6L29_RS06240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L29_RS06245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L29_RS06260	COG2831	hemolysin activation secretion protein
I6L29_RS06265	COG3210	domain, Protein
I6L29_RS06320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L29_RS06325	COG1120	ATPase activity
I6L29_RS06345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L29_RS06395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L29_RS06440	COG3539	Fimbrial protein
I6L29_RS06465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L29_RS06475	COG0753	catalase activity
I6L29_RS06495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L29_RS06505	COG2205	protein histidine kinase activity
I6L29_RS06510	COG0745	RESPONSE REGULATOR receiver
I6L29_RS06515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_RS06520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L29_RS06575	COG1535	isochorismatase
I6L29_RS06575	COG3433	isochorismatase activity
I6L29_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS06660	COG4397	Mu-like prophage major head subunit gpT
I6L29_RS06675	COG5005	Phage virion morphogenesis
I6L29_RS06685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L29_RS06690	COG4149	molybdate abc transporter
I6L29_RS06695	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L29_RS06705	COG4638	Rieske (2fe-2S)
I6L29_RS06710	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6L29_RS06715	COG0543	2 iron, 2 sulfur cluster binding
I6L29_RS06715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_RS06730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS06760	COG2207	Transcriptional regulator
I6L29_RS06765	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS06770	COG2610	gluconate transmembrane transporter activity
I6L29_RS06810	COG0583	DNA-binding transcription factor activity
I6L29_RS06825	COG2031	fatty acid transporter
I6L29_RS06830	COG0183	Belongs to the thiolase family
I6L29_RS06835	COG0583	DNA-binding transcription factor activity
I6L29_RS06840	COG0583	DNA-binding transcription factor activity
I6L29_RS06855	COG1027	Aspartate ammonia-lyase
I6L29_RS06865	COG0477	Major facilitator Superfamily
I6L29_RS06875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L29_RS06880	COG1733	regulation of RNA biosynthetic process
I6L29_RS06885	COG3708	Transcriptional regulator
I6L29_RS06885	COG2207	Transcriptional regulator
I6L29_RS06900	COG0730	response to heat
I6L29_RS06920	COG3781	membrane
I6L29_RS06925	COG1063	alcohol dehydrogenase
I6L29_RS06935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L29_RS06940	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_RS06945	COG0022	dehydrogenase e1 component
I6L29_RS06950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6L29_RS06955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L29_RS06970	COG3706	GGDEF domain
I6L29_RS06990	COG0133	tryptophan synthase activity
I6L29_RS07000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L29_RS07030	COG0583	DNA-binding transcription factor activity
I6L29_RS07035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L29_RS07040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L29_RS07045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L29_RS07105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L29_RS07110	COG4773	Receptor
I6L29_RS07135	COG0730	response to heat
I6L29_RS07140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L29_RS07160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6L29_RS07175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L29_RS07185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L29_RS07200	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS07205	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS07210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L29_RS07215	COG2207	Transcriptional regulator
I6L29_RS07220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L29_RS07225	COG0776	regulation of translation
I6L29_RS07250	COG0822	iron-sulfur transferase activity
I6L29_RS07255	COG0316	Belongs to the HesB IscA family
I6L29_RS07285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L29_RS07305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L29_RS07310	COG0702	epimerase
I6L29_RS07345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L29_RS07350	COG0601	transmembrane transport
I6L29_RS07355	COG0339	signal peptide processing
I6L29_RS07360	COG4166	transmembrane transport
I6L29_RS07405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L29_RS07410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L29_RS07425	COG2431	L-lysine efflux transmembrane transporter activity
I6L29_RS07440	COG0776	regulation of translation
I6L29_RS07505	COG0084	hydrolase, TatD family'
I6L29_RS07525	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L29_RS07530	COG1132	(ABC) transporter
I6L29_RS07540	COG0811	peptide transport
I6L29_RS07545	COG1475	DNA binding
I6L29_RS07550	COG1192	Involved in chromosome partitioning
I6L29_RS07560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L29_RS07565	COG3178	'Phosphotransferase
I6L29_RS07575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L29_RS07600	COG0424	maF-like protein
I6L29_RS07605	COG2850	peptidyl-arginine hydroxylation
I6L29_RS07615	COG0640	Transcriptional regulator
I6L29_RS07625	COG3619	membrane
I6L29_RS07630	COG3122	Protein conserved in bacteria
I6L29_RS07635	COG1132	(ABC) transporter
I6L29_RS07655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L29_RS07660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L29_RS07670	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L29_RS07670	COG0506	proline dehydrogenase activity
I6L29_RS07670	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L29_RS07675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6L29_RS07690	COG3698	Phosphodiester glycosidase
I6L29_RS07700	COG2353	YceI-like domain
I6L29_RS07710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L29_RS07755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L29_RS07755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L29_RS07780	COG3539	Fimbrial protein
I6L29_RS07815	COG0583	DNA-binding transcription factor activity
I6L29_RS07820	COG0697	spore germination
I6L29_RS07830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L29_RS07840	COG0583	DNA-binding transcription factor activity
I6L29_RS07855	COG1309	transcriptional regulator
I6L29_RS07870	COG1522	sequence-specific DNA binding
I6L29_RS07880	COG1126	abc transporter atp-binding protein
I6L29_RS07885	COG0765	amino acid transport
I6L29_RS07890	COG0765	amino acid transport
I6L29_RS07920	COG1464	Belongs to the NlpA lipoprotein family
I6L29_RS07925	COG1464	Belongs to the NlpA lipoprotein family
I6L29_RS07930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L29_RS07935	COG2011	ABC-type metal ion transport system permease component
I6L29_RS07940	COG0012	GTP binding
I6L29_RS07965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L29_RS08000	COG1917	Cupin 2, conserved barrel domain protein
I6L29_RS08000	COG2207	Transcriptional regulator
I6L29_RS08005	COG0386	Belongs to the glutathione peroxidase family
I6L29_RS08015	COG0436	Aminotransferase
I6L29_RS08020	COG1301	dicarboxylic acid transport
I6L29_RS08055	COG3634	alkyl hydroperoxide reductase activity
I6L29_RS08070	COG0583	DNA-binding transcription factor activity
I6L29_RS08075	COG0431	NADPH-dependent FMN reductase
I6L29_RS08080	COG0798	PFAM Bile acid sodium symporter
I6L29_RS08090	COG0640	Transcriptional regulator
I6L29_RS08105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6L29_RS08115	COG0583	DNA-binding transcription factor activity
I6L29_RS08125	COG1953	Uracil, thiamine, allantoin
I6L29_RS08135	COG2175	clavaminate synthase activity
I6L29_RS08140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_RS08145	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L29_RS08150	COG4521	taurine ABC transporter
I6L29_RS08160	COG0477	Major facilitator Superfamily
I6L29_RS08180	COG1271	oxidase subunit
I6L29_RS08185	COG1294	oxidase, subunit
I6L29_RS08195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_RS08215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L29_RS08235	COG3052	prosthetic group binding
I6L29_RS08240	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6L29_RS08265	COG1346	cytolysis
I6L29_RS08275	COG0583	DNA-binding transcription factor activity
I6L29_RS08280	COG0625	glutathione transferase activity
I6L29_RS08285	COG0625	glutathione transferase activity
I6L29_RS08290	COG0583	DNA-binding transcription factor activity
I6L29_RS08295	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS08305	COG1045	serine acetyltransferase
I6L29_RS08310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L29_RS08315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L29_RS08325	COG1280	lysine exporter protein (LysE YggA)
I6L29_RS08340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L29_RS08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L29_RS08355	COG0765	amino acid transport
I6L29_RS08360	COG0765	amino acid transport
I6L29_RS08380	COG2205	protein histidine kinase activity
I6L29_RS08380	COG0784	Response regulator, receiver
I6L29_RS08400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L29_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS08465	COG0583	DNA-binding transcription factor activity
I6L29_RS08475	COG2814	Major facilitator Superfamily
I6L29_RS08490	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_RS08495	COG1309	transcriptional regulator
I6L29_RS08500	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS08505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L29_RS08510	COG1024	Enoyl-CoA hydratase
I6L29_RS08515	COG4770	biotin carboxylase activity
I6L29_RS08525	COG0583	DNA-binding transcription factor activity
I6L29_RS08540	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS08550	COG2814	Major facilitator Superfamily
I6L29_RS08560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L29_RS08565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L29_RS08570	COG2814	Major facilitator Superfamily
I6L29_RS08575	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS08580	COG1024	Enoyl-CoA hydratase
I6L29_RS08590	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L29_RS08595	COG0183	Belongs to the thiolase family
I6L29_RS08605	COG2814	Major facilitator Superfamily
I6L29_RS08615	COG1024	Enoyl-CoA hydratase
I6L29_RS08625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L29_RS08630	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS08635	COG2814	Major facilitator Superfamily
I6L29_RS08640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L29_RS08645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L29_RS08660	COG3842	ATPase activity
I6L29_RS08665	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L29_RS08680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_RS08685	COG1414	Transcriptional regulator
I6L29_RS08695	COG0583	DNA-binding transcription factor activity
I6L29_RS08700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L29_RS08705	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS08715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L29_RS08725	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS08730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_RS08735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_RS08740	COG2267	carboxylic ester hydrolase activity
I6L29_RS08785	COG2050	protein possibly involved in aromatic compounds catabolism
I6L29_RS08795	COG3327	negative regulation of DNA-templated transcription, initiation
I6L29_RS08800	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6L29_RS08805	COG0183	Belongs to the thiolase family
I6L29_RS08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L29_RS08815	COG1024	Enoyl-CoA hydratase
I6L29_RS08820	COG1024	Enoyl-CoA hydratase
I6L29_RS08825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_RS08830	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L29_RS08835	COG3396	Phenylacetate-CoA oxygenase
I6L29_RS08840	COG3460	Phenylacetate-CoA oxygenase
I6L29_RS08845	COG3396	Phenylacetate-CoA oxygenase
I6L29_RS08850	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS08850	COG2030	dehydratase
I6L29_RS08855	COG1760	l-serine dehydratase
I6L29_RS08870	COG0789	Transcriptional regulator
I6L29_RS08880	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L29_RS08885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_RS08900	COG2807	transmembrane transport
I6L29_RS08905	COG0590	tRNA wobble adenosine to inosine editing
I6L29_RS08910	COG0666	response to abiotic stimulus
I6L29_RS08955	COG2885	chlorophyll binding
I6L29_RS08975	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L29_RS09005	COG3210	domain, Protein
I6L29_RS09010	COG2831	hemolysin activation secretion protein
I6L29_RS09015	COG0038	chloride channel
I6L29_RS09020	COG4770	biotin carboxylase activity
I6L29_RS09040	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L29_RS09045	COG0583	DNA-binding transcription factor activity
I6L29_RS09055	COG1595	DNA-templated transcription, initiation
I6L29_RS09065	COG3220	belongs to the UPF0276 family
I6L29_RS09115	COG0702	epimerase
I6L29_RS09120	COG1733	regulation of RNA biosynthetic process
I6L29_RS09130	COG1234	tRNA 3'-trailer cleavage
I6L29_RS09135	COG1051	belongs to the nudix hydrolase family
I6L29_RS09150	COG3712	iron ion homeostasis
I6L29_RS09200	COG3038	cytochrome b561
I6L29_RS09205	COG0753	catalase activity
I6L29_RS09210	COG1733	regulation of RNA biosynthetic process
I6L29_RS09235	COG0531	amino acid
I6L29_RS09240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L29_RS09255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L29_RS09270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L29_RS09280	COG4122	O-methyltransferase activity
I6L29_RS09315	COG1137	ATPase activity
I6L29_RS09320	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L29_RS09330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L29_RS09355	COG0668	transmembrane transport
I6L29_RS09400	COG1309	transcriptional regulator
I6L29_RS09430	COG2226	methyltransferase
I6L29_RS09455	COG1278	Cold shock
I6L29_RS09460	COG1560	Kdo2-lipid A biosynthetic process
I6L29_RS09465	COG1280	lysine exporter protein (LysE YggA)
I6L29_RS09500	COG1570	exodeoxyribonuclease VII activity
I6L29_RS09585	COG2871	sodium ion transport
I6L29_RS09595	COG0583	DNA-binding transcription factor activity
I6L29_RS09605	COG4638	Rieske (2fe-2S)
I6L29_RS09615	COG0633	Ferredoxin
I6L29_RS09615	COG0543	2 iron, 2 sulfur cluster binding
I6L29_RS09620	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS09625	COG3135	benzoate transporter
I6L29_RS09630	COG2814	Major facilitator Superfamily
I6L29_RS09645	COG1643	Atp-dependent helicase
I6L29_RS09670	COG3634	alkyl hydroperoxide reductase activity
I6L29_RS09690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L29_RS09710	COG0625	glutathione transferase activity
I6L29_RS09720	COG2885	chlorophyll binding
I6L29_RS09755	COG0542	response to heat
I6L29_RS09770	COG1765	OsmC-like protein
I6L29_RS09785	COG0667	Aldo Keto reductase
I6L29_RS09800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L29_RS09815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L29_RS09825	COG0582	viral genome integration into host DNA
I6L29_RS09840	COG3293	Transposase
I6L29_RS09845	COG1063	alcohol dehydrogenase
I6L29_RS09895	COG1196	nuclear chromosome segregation
I6L29_RS09895	COG0739	heme binding
I6L29_RS09895	COG0741	lytic transglycosylase activity
I6L29_RS09910	COG1598	PFAM Uncharacterised protein family UPF0150
I6L29_RS10190	COG0527	aspartate kinase activity
I6L29_RS10200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L29_RS10210	COG3038	cytochrome b561
I6L29_RS10215	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L29_RS10220	COG2252	PERMEase
I6L29_RS10230	COG1741	Belongs to the pirin family
I6L29_RS10235	COG1309	transcriptional regulator
I6L29_RS10250	COG2072	flavoprotein involved in K transport
I6L29_RS10255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6L29_RS10260	COG0583	DNA-binding transcription factor activity
I6L29_RS10275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L29_RS10305	COG1944	ATP diphosphatase activity
I6L29_RS10325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L29_RS10340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_RS10355	COG2814	Major facilitator Superfamily
I6L29_RS10360	COG1024	Enoyl-CoA hydratase
I6L29_RS10365	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS10375	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS10400	COG2186	Transcriptional regulator
I6L29_RS10405	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS10415	COG4948	Mandelate Racemase Muconate Lactonizing
I6L29_RS10420	COG2271	Major facilitator Superfamily
I6L29_RS10425	COG2721	sulfolactate sulfo-lyase activity
I6L29_RS10430	COG0697	spore germination
I6L29_RS10450	COG3210	domain, Protein
I6L29_RS10455	COG2831	hemolysin activation secretion protein
I6L29_RS10460	COG1113	amino acid transport
I6L29_RS10480	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS10500	COG0531	amino acid
I6L29_RS10510	COG1113	amino acid transport
I6L29_RS10550	COG4269	membrane
I6L29_RS10570	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L29_RS10570	COG1902	pentaerythritol trinitrate reductase activity
I6L29_RS10580	COG2203	Gaf domain
I6L29_RS10580	COG4251	negative regulation of phosphorylation
I6L29_RS10580	COG5001	Diguanylate cyclase
I6L29_RS10580	COG3706	GGDEF domain
I6L29_RS10590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L29_RS10615	COG4172	Belongs to the ABC transporter superfamily
I6L29_RS10620	COG4239	(ABC) transporter, permease
I6L29_RS10625	COG4174	ABC transporter (Permease)
I6L29_RS10630	COG4166	transmembrane transport
I6L29_RS10635	COG0741	lytic transglycosylase activity
I6L29_RS10635	COG1388	LysM domain
I6L29_RS10635	COG0741	lytic transglycosylase activity
I6L29_RS10635	COG1388	LysM domain
I6L29_RS10680	COG0583	DNA-binding transcription factor activity
I6L29_RS10685	COG1279	arginine transmembrane transporter activity
I6L29_RS10695	COG0789	Transcriptional regulator
I6L29_RS10705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_RS10710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_RS10715	COG0006	proline dipeptidase activity
I6L29_RS10755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L29_RS10770	COG3384	dioxygenase
I6L29_RS10780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L29_RS10785	COG2878	Part of a membrane complex involved in electron transport
I6L29_RS10790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L29_RS10815	COG0768	penicillin binding
I6L29_RS10820	COG0742	ribosomal rna small subunit methyltransferase
I6L29_RS10835	COG0830	nickel cation binding
I6L29_RS10845	COG0804	urea catabolic process
I6L29_RS10870	COG3015	lipoprotein NlpE involved in copper resistance
I6L29_RS10885	COG1253	flavin adenine dinucleotide binding
I6L29_RS10890	COG2851	Citrate transporter
I6L29_RS10940	COG1773	rubredoxin
I6L29_RS10945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L29_RS10950	COG2267	carboxylic ester hydrolase activity
I6L29_RS10955	COG0583	DNA-binding transcription factor activity
I6L29_RS10985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L29_RS10990	COG4181	ATPase activity
I6L29_RS11035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L29_RS11055	COG0306	phosphate transporter
I6L29_RS11085	COG2223	nitrite transmembrane transporter activity
I6L29_RS11090	COG2207	Transcriptional regulator
I6L29_RS11095	COG2066	Belongs to the glutaminase family
I6L29_RS11100	COG0242	peptide deformylase activity
I6L29_RS11105	COG0477	Major facilitator Superfamily
I6L29_RS11115	COG0028	Belongs to the TPP enzyme family
I6L29_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS11135	COG2267	carboxylic ester hydrolase activity
I6L29_RS11145	COG2271	Major facilitator Superfamily
I6L29_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS11180	COG1414	Transcriptional regulator
I6L29_RS11195	COG1024	Enoyl-CoA hydratase
I6L29_RS11205	COG1215	transferase activity, transferring glycosyl groups
I6L29_RS11210	COG0726	polysaccharide deacetylase
I6L29_RS11210	COG1649	PFAM Uncharacterised BCR, COG1649
I6L29_RS11220	COG4681	YaeQ
I6L29_RS11230	COG0523	cobalamin synthesis protein
I6L29_RS11240	COG1607	acyl-coa hydrolase
I6L29_RS11250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L29_RS11255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L29_RS11260	COG1309	transcriptional regulator
I6L29_RS11285	COG2040	homocysteine
I6L29_RS11290	COG0531	amino acid
I6L29_RS11340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L29_RS11345	COG2814	Major facilitator Superfamily
I6L29_RS11390	COG1401	restriction endodeoxyribonuclease activity
I6L29_RS11400	COG0405	Gamma-glutamyltransferase
I6L29_RS11405	COG2814	Major facilitator Superfamily
I6L29_RS11415	COG2050	protein possibly involved in aromatic compounds catabolism
I6L29_RS11430	COG1090	epimerase
I6L29_RS11450	COG0420	3'-5' exonuclease activity
I6L29_RS11475	COG0735	belongs to the Fur family
I6L29_RS11480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L29_RS11485	COG2914	Belongs to the UPF0125 (RnfH) family
I6L29_RS11500	COG0121	glutamine amidotransferase
I6L29_RS11515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L29_RS11525	COG0210	DNA helicase
I6L29_RS11530	COG2885	chlorophyll binding
I6L29_RS11535	COG0204	Acyl-transferase
I6L29_RS11550	COG2894	cell division
I6L29_RS11565	COG1280	lysine exporter protein (LysE YggA)
I6L29_RS11570	COG1674	ftsk spoiiie
I6L29_RS11575	COG0492	ferredoxin-NADP+ reductase activity
I6L29_RS11580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L29_RS11590	COG0456	acetyltransferase
I6L29_RS11605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L29_RS11610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L29_RS11620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L29_RS11635	COG1981	membrane
I6L29_RS11645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L29_RS11645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L29_RS11665	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS11670	COG4638	Rieske (2fe-2S)
I6L29_RS11675	COG0657	acetylesterase activity
I6L29_RS11685	COG0473	3-isopropylmalate dehydrogenase activity
I6L29_RS11690	COG0583	DNA-binding transcription factor activity
I6L29_RS11710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L29_RS11745	COG0358	DNA primase activity
I6L29_RS11760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L29_RS11790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L29_RS11820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L29_RS11830	COG0351	phosphomethylpyrimidine kinase
I6L29_RS11830	COG0352	thiamine-phosphate diphosphorylase activity
I6L29_RS11830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L29_RS11835	COG1652	LysM domain
I6L29_RS11860	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L29_RS11865	COG3101	peptidyl-lysine hydroxylation
I6L29_RS11870	COG0009	L-threonylcarbamoyladenylate synthase
I6L29_RS11875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L29_RS11880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L29_RS11895	COG4106	trans-aconitate 2-methyltransferase activity
I6L29_RS11910	COG0596	Alpha beta hydrolase
I6L29_RS11910	COG2226	methyltransferase
I6L29_RS11910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L29_RS11920	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6L29_RS11925	COG2223	nitrite transmembrane transporter activity
I6L29_RS11945	COG1196	nuclear chromosome segregation
I6L29_RS11955	COG0730	response to heat
I6L29_RS11970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L29_RS11980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L29_RS12030	COG0489	protein tyrosine kinase activity
I6L29_RS12040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L29_RS12040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L29_RS12075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L29_RS12080	COG2081	HI0933 family
I6L29_RS12090	COG0668	transmembrane transport
I6L29_RS12110	COG0583	DNA-binding transcription factor activity
I6L29_RS12130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L29_RS12135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L29_RS12165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L29_RS12190	COG2199	diguanylate cyclase activity
I6L29_RS12205	COG0745	RESPONSE REGULATOR receiver
I6L29_RS12220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L29_RS12260	COG0110	maltose O-acetyltransferase activity
I6L29_RS12265	COG0438	transferase activity, transferring glycosyl groups
I6L29_RS12275	COG3328	transposase activity
I6L29_RS12320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_RS12335	COG0583	DNA-binding transcription factor activity
I6L29_RS12370	COG0583	DNA-binding transcription factor activity
I6L29_RS12385	COG0583	DNA-binding transcription factor activity
I6L29_RS12390	COG1053	succinate dehydrogenase
I6L29_RS12405	COG1309	transcriptional regulator
I6L29_RS12415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L29_RS12420	COG2814	Major facilitator Superfamily
I6L29_RS12425	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS12430	COG0583	DNA-binding transcription factor activity
I6L29_RS12460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L29_RS12465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L29_RS12470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L29_RS12490	COG2132	Multicopper oxidase
I6L29_RS12500	COG0561	phosphatase activity
I6L29_RS12505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L29_RS12515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L29_RS12530	COG1214	PFAM Peptidase M22, glycoprotease
I6L29_RS12590	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L29_RS12595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L29_RS12600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L29_RS12660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L29_RS12670	COG1846	Transcriptional regulator
I6L29_RS12675	COG1764	response to oxidative stress
I6L29_RS12715	COG0037	tRNA processing
I6L29_RS12725	COG0248	Ppx GppA phosphatase
I6L29_RS12755	COG0072	phenylalanine-tRNA ligase activity
I6L29_RS12780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L29_RS12795	COG1238	metal cluster binding
I6L29_RS12800	COG0625	glutathione transferase activity
I6L29_RS12815	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_RS12820	COG3028	Belongs to the UPF0307 family
I6L29_RS12825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L29_RS12845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L29_RS12850	COG0617	tRNA 3'-terminal CCA addition
I6L29_RS12855	COG1555	photosystem II stabilization
I6L29_RS12860	COG3956	TIGRFAM MazG family protein
I6L29_RS12870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L29_RS12885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L29_RS12890	COG5002	protein histidine kinase activity
I6L29_RS12890	COG2205	protein histidine kinase activity
I6L29_RS12890	COG0784	Response regulator, receiver
I6L29_RS12895	COG1024	Enoyl-CoA hydratase
I6L29_RS12900	COG2084	Dehydrogenase
I6L29_RS12905	COG3622	Belongs to the hyi family
I6L29_RS12940	COG0697	spore germination
I6L29_RS12950	COG2814	Major facilitator Superfamily
I6L29_RS13000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L29_RS13025	COG2132	Multicopper oxidase
I6L29_RS13040	COG2205	protein histidine kinase activity
I6L29_RS13125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L29_RS13140	COG0583	DNA-binding transcription factor activity
I6L29_RS13150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L29_RS13160	COG0084	hydrolase, TatD family'
I6L29_RS13175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L29_RS13195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L29_RS13200	COG0440	acetolactate synthase activity
I6L29_RS13205	COG0028	Belongs to the TPP enzyme family
I6L29_RS13225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_RS13230	COG1136	(ABC) transporter
I6L29_RS13230	COG0577	efflux transmembrane transporter activity
I6L29_RS13260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L29_RS13265	COG1162	GTPase activity
I6L29_RS13275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L29_RS13295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L29_RS13315	COG1426	Protein conserved in bacteria
I6L29_RS13350	COG0793	Belongs to the peptidase S41A family
I6L29_RS13365	COG2267	carboxylic ester hydrolase activity
I6L29_RS13375	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS13380	COG3265	gluconokinase activity
I6L29_RS13390	COG0800	Aldolase
I6L29_RS13405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L29_RS13410	COG0857	belongs to the CobB CobQ family
I6L29_RS13410	COG0280	phosphate acetyltransferase
I6L29_RS13415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L29_RS13415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L29_RS13435	COG0740	serine-type endopeptidase activity
I6L29_RS13445	COG4774	siderophore transport
I6L29_RS13455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L29_RS13465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6L29_RS13465	COG2813	Specifically methylates the guanine in position
I6L29_RS13565	COG0788	formyltetrahydrofolate deformylase activity
I6L29_RS13590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L29_RS13590	COG4651	solute:proton antiporter activity
I6L29_RS13610	COG0724	RNA recognition motif
I6L29_RS13615	COG0210	DNA helicase
I6L29_RS13640	COG1733	regulation of RNA biosynthetic process
I6L29_RS13645	COG0604	alcohol dehydrogenase
I6L29_RS13650	COG2900	Belongs to the SlyX family
I6L29_RS13655	COG0488	(ABC) transporter
I6L29_RS13665	COG1560	Kdo2-lipid A biosynthetic process
I6L29_RS13675	COG1301	dicarboxylic acid transport
I6L29_RS13730	COG0473	3-isopropylmalate dehydrogenase activity
I6L29_RS13755	COG0583	DNA-binding transcription factor activity
I6L29_RS13795	COG0583	DNA-binding transcription factor activity
I6L29_RS13805	COG0625	glutathione transferase activity
I6L29_RS13810	COG2378	regulation of single-species biofilm formation
I6L29_RS13815	COG0546	phosphoglycolate phosphatase activity
I6L29_RS13825	COG1530	ribonuclease E activity
I6L29_RS13830	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_RS13845	COG0583	DNA-binding transcription factor activity
I6L29_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS13855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L29_RS13865	COG0534	Mate efflux family protein
I6L29_RS13880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L29_RS13905	COG0493	'glutamate synthase
I6L29_RS13905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L29_RS13915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L29_RS13920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L29_RS13935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L29_RS13945	COG0644	oxidoreductase
I6L29_RS13945	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L29_RS13960	COG4535	Mg2 and Co2 transporter CorC
I6L29_RS13970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L29_RS13990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L29_RS14000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L29_RS14010	COG0484	heat shock protein binding
I6L29_RS14015	COG0789	Transcriptional regulator
I6L29_RS14020	COG0598	Magnesium transport protein CorA
I6L29_RS14025	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L29_RS14035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L29_RS14040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L29_RS14045	COG1074	ATP-dependent DNA helicase activity
I6L29_RS14050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L29_RS14070	COG2226	methyltransferase
I6L29_RS14080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L29_RS14085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_RS14095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L29_RS14110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L29_RS14110	COG2111	Na H antiporter
I6L29_RS14115	COG1006	Multisubunit Na H antiporter MnhC subunit
I6L29_RS14120	COG0651	ATP synthesis coupled electron transport
I6L29_RS14125	COG1863	multisubunit Na H antiporter MnhE subunit
I6L29_RS14130	COG2212	antiporter activity
I6L29_RS14135	COG1320	monovalent cation:proton antiporter activity
I6L29_RS14140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L29_RS14150	COG0195	Participates in both transcription termination and antitermination
I6L29_RS14200	COG0237	dephospho-CoA kinase activity
I6L29_RS14210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L29_RS14225	COG0497	DNA recombination
I6L29_RS14235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L29_RS14270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L29_RS14270	COG2169	Transcriptional regulator
I6L29_RS14275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L29_RS14345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L29_RS14360	COG0326	Molecular chaperone. Has ATPase activity
I6L29_RS14375	COG2056	Na+-H+ antiporter family
I6L29_RS14445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L29_RS14475	COG0546	phosphoglycolate phosphatase activity
I6L29_RS14480	COG1716	ATPase activity
I6L29_RS14525	COG0181	hydroxymethylbilane synthase activity
I6L29_RS14535	COG3275	phosphorelay sensor kinase activity
I6L29_RS14555	COG1538	Outer membrane efflux protein
I6L29_RS14565	COG0697	spore germination
I6L29_RS14585	COG0494	nUDIX hydrolase
I6L29_RS14590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L29_RS14595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L29_RS14600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L29_RS14605	COG0772	Belongs to the SEDS family
I6L29_RS14630	COG4974	Belongs to the 'phage' integrase family
I6L29_RS14635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L29_RS14645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L29_RS14655	COG2197	response regulator
I6L29_RS14670	COG0793	Belongs to the peptidase S41A family
I6L29_RS14675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L29_RS14680	COG0795	lipopolysaccharide-transporting ATPase activity
I6L29_RS14720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L29_RS14720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L29_RS14730	COG0004	ammonium transporteR
I6L29_RS14735	COG0347	Belongs to the P(II) protein family
I6L29_RS14745	COG0606	chelatase, subunit chli
I6L29_RS14750	COG0431	NADPH-dependent FMN reductase
I6L29_RS14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_RS14760	COG0235	Class ii aldolase
I6L29_RS14765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L29_RS14785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L29_RS14800	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_RS14810	COG0477	Major facilitator Superfamily
I6L29_RS14815	COG2860	membrane
I6L29_RS14825	COG1253	flavin adenine dinucleotide binding
I6L29_RS14835	COG2814	Major facilitator Superfamily
I6L29_RS14845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L29_RS14885	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6L29_RS14900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L29_RS14965	COG0758	DNA mediated transformation
I6L29_RS14975	COG0697	spore germination
I6L29_RS14980	COG1309	transcriptional regulator
I6L29_RS14995	COG0386	Belongs to the glutathione peroxidase family
I6L29_RS15010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L29_RS15020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L29_RS15060	COG1121	(ABC) transporter
I6L29_RS15065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L29_RS15070	COG1280	lysine exporter protein (LysE YggA)
I6L29_RS15075	COG2837	iron assimilation
I6L29_RS15080	COG0281	malic enzyme
I6L29_RS15125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L29_RS15125	COG0519	Catalyzes the synthesis of GMP from XMP
I6L29_RS15130	COG4399	Belongs to the UPF0754 family
I6L29_RS15135	COG2259	Doxx family
I6L29_RS15140	COG0586	Pfam SNARE associated Golgi protein
I6L29_RS15155	COG1192	Involved in chromosome partitioning
I6L29_RS15165	COG0271	Belongs to the BolA IbaG family
I6L29_RS15205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L29_RS15205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L29_RS15205	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L29_RS15205	COG3321	synthase
I6L29_RS15210	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS15215	COG0318	PFAM AMP-dependent synthetase and ligase
I6L29_RS15220	COG2197	response regulator
I6L29_RS15230	COG3916	Acyl-homoserine-lactone synthase
I6L29_RS15235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_RS15245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L29_RS15250	COG1113	amino acid transport
I6L29_RS15255	COG0697	spore germination
I6L29_RS15260	COG0477	Major facilitator Superfamily
I6L29_RS15265	COG1024	Enoyl-CoA hydratase
I6L29_RS15270	COG1024	Enoyl-CoA hydratase
I6L29_RS15275	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS15280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L29_RS15300	COG1113	amino acid transport
I6L29_RS15305	COG1113	amino acid transport
I6L29_RS15310	COG0251	oxidation-reduction process
I6L29_RS15350	COG0564	pseudouridine synthase activity
I6L29_RS15380	COG3328	transposase activity
I6L29_RS15435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L29_RS15450	COG1802	Transcriptional regulator
I6L29_RS15460	COG1448	Aminotransferase
I6L29_RS15465	COG0277	FAD linked oxidase domain protein
I6L29_RS15475	COG2186	Transcriptional regulator
I6L29_RS15485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L29_RS15500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L29_RS15505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L29_RS15540	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L29_RS15565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L29_RS15595	COG0728	peptidoglycan biosynthetic process
I6L29_RS15600	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L29_RS15655	COG0546	phosphoglycolate phosphatase activity
I6L29_RS15660	COG1028	Short-chain dehydrogenase reductase Sdr
I6L29_RS15675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L29_RS15675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L29_RS15680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_RS15685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L29_RS15690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L29_RS15695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L29_RS15700	COG1116	anion transmembrane transporter activity
I6L29_RS15705	COG1309	transcriptional regulator
I6L29_RS15710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L29_RS15720	COG0196	riboflavin kinase activity
I6L29_RS15725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L29_RS15735	COG1047	Peptidyl-prolyl cis-trans
I6L29_RS15775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L29_RS15780	COG0657	acetylesterase activity
I6L29_RS15800	COG0583	DNA-binding transcription factor activity
I6L29_RS15830	COG2951	lytic endotransglycosylase activity
I6L29_RS15835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L29_RS15850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L29_RS15860	COG0671	phosphoesterase, PA-phosphatase related
I6L29_RS15865	COG0861	Integral membrane protein TerC family
I6L29_RS15875	COG0754	glutathionylspermidine amidase activity
I6L29_RS15885	COG0402	S-adenosylhomocysteine deaminase activity
I6L29_RS15900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L29_RS15920	COG0706	membrane insertase activity
I6L29_RS15945	COG0592	DNA-directed DNA polymerase activity
I6L29_RS15955	COG0187	DNA topoisomerase II activity
I6L29_RS15970	COG0488	(ABC) transporter
I6L29_RS15995	COG0596	Alpha beta hydrolase
I6L29_RS16000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L29_RS16005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L29_RS16035	COG0625	glutathione transferase activity
I6L29_RS16045	COG0733	neurotransmitter:sodium symporter activity
I6L29_RS16085	COG2233	PERMEase
I6L29_RS16100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L29_RS16135	COG2814	Major facilitator Superfamily
I6L29_RS16140	COG0656	L-ascorbic acid biosynthetic process
I6L29_RS16145	COG0583	DNA-binding transcription factor activity
I6L29_RS16160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L29_RS16165	COG1064	alcohol dehydrogenase
I6L29_RS16170	COG2818	Glycosylase
I6L29_RS16185	COG1194	a g-specific adenine glycosylase
I6L29_RS16200	COG5487	UPF0391 membrane protein
I6L29_RS16205	COG2983	Belongs to the UPF0260 family
I6L29_RS16210	COG2133	pyrroloquinoline quinone binding
I6L29_RS16215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L29_RS16220	COG2116	formate transmembrane transporter activity
I6L29_RS16240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L29_RS16245	COG1335	isochorismatase
I6L29_RS16250	COG0385	Bile acid
I6L29_RS16255	COG0534	Mate efflux family protein
I6L29_RS16260	COG1683	Conserved Protein
I6L29_RS16275	COG0346	lactoylglutathione lyase activity
I6L29_RS16280	COG0625	glutathione transferase activity
I6L29_RS16290	COG1113	amino acid transport
I6L29_RS16300	COG0523	cobalamin synthesis protein
I6L29_RS16310	COG2188	Transcriptional regulator
I6L29_RS16340	COG0010	Belongs to the arginase family
I6L29_RS16375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L29_RS16385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L29_RS16390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L29_RS16490	COG0534	Mate efflux family protein
I6L29_RS16495	COG0436	Aminotransferase
I6L29_RS16500	COG2733	membrane
I6L29_RS16515	COG2918	glutathione biosynthetic process
I6L29_RS16560	COG3150	esterase
I6L29_RS16570	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6L29_RS16580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L29_RS16590	COG2233	PERMEase
I6L29_RS16595	COG2351	hydroxyisourate hydrolase activity
I6L29_RS16630	COG3706	GGDEF domain
I6L29_RS16645	COG1393	Belongs to the ArsC family
I6L29_RS16650	COG0708	Exodeoxyribonuclease III
I6L29_RS16670	COG0189	ligase activity
I6L29_RS16690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L29_RS16700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L29_RS16715	COG4942	peptidase
I6L29_RS16725	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L29_RS16735	COG2119	membrane
I6L29_RS16740	COG4774	siderophore transport
I6L29_RS16745	COG0426	domain, Protein
I6L29_RS16745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L29_RS16765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L29_RS16785	COG1902	pentaerythritol trinitrate reductase activity
I6L29_RS16790	COG1519	Transferase
I6L29_RS16795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L29_RS16800	COG0668	transmembrane transport
I6L29_RS16810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L29_RS16815	COG1335	isochorismatase
I6L29_RS16820	COG1522	sequence-specific DNA binding
I6L29_RS16845	COG0784	Response regulator, receiver
I6L29_RS16845	COG2198	Histidine kinase
I6L29_RS16845	COG2205	protein histidine kinase activity
I6L29_RS16850	COG3162	membrane
I6L29_RS16855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L29_RS16865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L29_RS16890	COG1309	transcriptional regulator
I6L29_RS16910	COG0300	oxidoreductase activity
I6L29_RS16915	COG0789	Transcriptional regulator
I6L29_RS16920	COG0352	thiamine-phosphate diphosphorylase activity
I6L29_RS16920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6L29_RS16920	COG0351	phosphomethylpyrimidine kinase
I6L29_RS16930	COG2814	Major facilitator Superfamily
I6L29_RS16945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L29_RS16955	COG1113	amino acid transport
I6L29_RS16965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L29_RS16970	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS16980	COG1335	isochorismatase
I6L29_RS17020	COG2814	Major facilitator Superfamily
I6L29_RS17025	COG0583	DNA-binding transcription factor activity
I6L29_RS17045	COG0667	Aldo Keto reductase
I6L29_RS17060	COG1309	transcriptional regulator
I6L29_RS17080	COG1733	regulation of RNA biosynthetic process
I6L29_RS17085	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L29_RS17170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L29_RS17185	COG2329	Antibiotic biosynthesis monooxygenase
I6L29_RS17190	COG0697	spore germination
I6L29_RS17200	COG1132	(ABC) transporter
I6L29_RS17210	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L29_RS17220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L29_RS17250	COG0427	acetyl-CoA hydrolase
I6L29_RS17275	COG0659	secondary active sulfate transmembrane transporter activity
I6L29_RS17280	COG4221	oxidoreductase activity
I6L29_RS17285	COG2873	o-acetylhomoserine
I6L29_RS17290	COG0488	(ABC) transporter
I6L29_RS17370	COG0833	amino acid
I6L29_RS17415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L29_RS17420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L29_RS17435	COG2226	methyltransferase
I6L29_RS17485	COG0070	glutamate synthase
I6L29_RS17485	COG0069	glutamate synthase activity
I6L29_RS17485	COG0067	glutamate synthase
I6L29_RS17490	COG0493	'glutamate synthase
I6L29_RS17500	COG1704	LemA family
I6L29_RS17505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L29_RS17515	COG4969	Belongs to the N-Me-Phe pilin family
I6L29_RS17525	COG3328	transposase activity
I6L29_RS17535	COG3307	-O-antigen
I6L29_RS17560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L29_RS17575	COG0194	GDP metabolic process
I6L29_RS17625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L29_RS17635	COG0335	large ribosomal subunit rRNA binding
I6L29_RS17645	COG5380	lipid catabolic process
I6L29_RS17650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L29_RS17665	COG5006	permease, DMT superfamily
I6L29_RS17670	COG5006	permease, DMT superfamily
I6L29_RS17675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L29_RS17680	COG0277	FAD linked oxidase domain protein
I6L29_RS17690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L29_RS17695	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L29_RS17710	COG1289	transmembrane transporter activity
I6L29_RS17720	COG0628	permease
I6L29_RS17725	COG1192	Involved in chromosome partitioning
I6L29_RS17755	COG0833	amino acid
I6L29_RS17760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L29_RS17765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L29_RS17775	COG1012	belongs to the aldehyde dehydrogenase family
I6L29_RS17815	COG0583	DNA-binding transcription factor activity
I6L29_RS17845	COG0752	glycyl-tRNA synthetase alpha subunit
I6L29_RS17865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L29_RS17865	COG0617	tRNA 3'-terminal CCA addition
I6L29_RS17865	COG0517	IMP dehydrogenase activity
I6L29_RS17870	COG1983	PspC domain protein
I6L29_RS17880	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS17895	COG0408	coproporphyrinogen oxidase activity
I6L29_RS17915	COG0513	Belongs to the DEAD box helicase family
I6L29_RS17925	COG1127	ABC transporter
I6L29_RS17930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L29_RS17940	COG2854	intermembrane phospholipid transfer
I6L29_RS17950	COG0598	Magnesium transport protein CorA
I6L29_RS17960	COG0494	nUDIX hydrolase
I6L29_RS17965	COG1040	competence protein
I6L29_RS17970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L29_RS17990	COG1946	Acyl-CoA thioesterase
I6L29_RS17995	COG1301	dicarboxylic acid transport
I6L29_RS18010	COG1959	2 iron, 2 sulfur cluster binding
I6L29_RS18015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L29_RS18015	COG1017	nitric oxide dioxygenase activity
I6L29_RS18025	COG0433	COG0433 Predicted ATPase
I6L29_RS18030	COG0626	cystathionine gamma-synthase activity
I6L29_RS18045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L29_RS18050	COG0088	Forms part of the polypeptide exit tunnel
I6L29_RS18185	COG1960	acyl-CoA dehydrogenase activity
I6L29_RS18190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L29_RS18220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L29_RS18225	COG0339	signal peptide processing
I6L29_RS18230	COG0557	exoribonuclease II activity
I6L29_RS18260	COG3328	transposase activity
I6L29_RS18285	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L29_RS18300	COG0477	Major facilitator Superfamily
I6L29_RS18305	COG0697	spore germination
I6L29_RS18315	COG3321	synthase
I6L29_RS18315	COG0604	alcohol dehydrogenase
I6L29_RS18320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L29_RS18330	COG3328	transposase activity
I6L29_RS18345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L29_RS18355	COG4772	TonB-dependent receptor
I6L29_RS18370	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L29_RS18410	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6L29_RS18490	COG3586	endonuclease activity
I6L29_RS18525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L29_RS18605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L29_RS18625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L29_RS18685	COG4372	Transposase
I6L29_RS18715	COG0358	DNA primase activity
I6L29_RS18735	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6L29_RS18795	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6L29_RS18815	COG3328	transposase activity
I6L29_RS18825	COG0582	viral genome integration into host DNA
I6L29_RS18840	COG2130	NADP-dependent
I6L29_RS18845	COG1309	transcriptional regulator
I6L29_RS18855	COG1902	pentaerythritol trinitrate reductase activity
I6L29_RS18865	COG1979	alcohol dehydrogenase
I6L29_RS18880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L29_RS18945	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6L29_RS19205	COG1538	Outer membrane efflux protein