locus-tag class description EPY81_RS00010 ENOG4105EEQ Na H antiporter EPY81_RS00015 ENOG4105CGZ zinc metallopeptidase EPY81_RS00020 ENOG4105CKW Inner membrane protein yedI EPY81_RS00030 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EPY81_RS00040 ENOG4107QN2 dihydrolipoyl dehydrogenase EPY81_RS00045 ENOG4105C7S Dehydrogenase EPY81_RS00050 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EPY81_RS00065 ENOG4105E33 succinate dehydrogenase EPY81_RS00075 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein EPY81_RS00080 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit EPY81_RS00115 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EPY81_RS00120 ENOG41084BA UPF0250 protein EPY81_RS00125 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EPY81_RS00135 ENOG4105C0A alcohol dehydrogenase EPY81_RS00140 ENOG4105CUB amino acid EPY81_RS00175 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EPY81_RS00180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EPY81_RS00195 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) EPY81_RS00220 ENOG410841Q phosphoesterase PA-phosphatase related protein EPY81_RS00225 ENOG4105C1P efflux transporter, rnd family, mfp subunit EPY81_RS00230 ENOG4105BZS acriflavin resistance protein EPY81_RS00235 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EPY81_RS00240 ENOG4105K8R UPF0145 protein EPY81_RS00245 ENOG41082CH UPF0145 protein EPY81_RS00265 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EPY81_RS00285 ENOG4108M0I Transcriptional regulator EPY81_RS00305 ENOG4105DHQ Histidine kinase EPY81_RS00310 ENOG4105XJC Two component transcriptional regulator (Winged helix family EPY81_RS00315 ENOG4105DIJ Phosphoethanolamine transferase EPY81_RS00340 ENOG4105D78 K07001 NTE family protein EPY81_RS00355 ENOG4105MSB protein, conserved in bacteria EPY81_RS00360 ENOG4105CTB Polyprenyl synthetase EPY81_RS00365 ENOG4105C7F AcnD-accessory protein PrpF EPY81_RS00370 ENOG4105C85 amino acid EPY81_RS00375 ENOG4105E09 nadh pyrophosphatase EPY81_RS00380 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein EPY81_RS00430 ENOG4105CDU Replicative dna helicase EPY81_RS00510 ENOG4105CF7 AraC family transcriptional regulator EPY81_RS00535 ENOG4108X0B nad(p)h dehydrogenase (quinone) EPY81_RS00545 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein EPY81_RS00555 ENOG4105D8T Acyltransferase EPY81_RS00565 ENOG4105C03 ribonuclease EPY81_RS00570 ENOG4108Z03 MAF-like protein EPY81_RS00575 ENOG4105VQ7 Rod shape-determining protein MreD EPY81_RS00580 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EPY81_RS00585 ENOG4105DFF Rod shape-determining protein mreb EPY81_RS00590 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EPY81_RS00600 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EPY81_RS00625 ENOG4105C9K Endothelin-converting enzyme 1 EPY81_RS00635 ENOG4105C7B Threonine dehydratase EPY81_RS00640 ENOG4105D78 K07001 NTE family protein EPY81_RS00645 ENOG4105BZG amino acid carrier protein EPY81_RS00665 ENOG4105C2C drug resistance transporter, Bcr CflA EPY81_RS00670 ENOG4105EM2 membrane EPY81_RS00680 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EPY81_RS00720 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EPY81_RS00725 ENOG4105WD1 Membrane EPY81_RS00735 ENOG4106HKS Entericidin EcnA/B family EPY81_RS00750 ENOG4105CBS Chea signal transduction histidine kinase EPY81_RS00755 ENOG4105C8Q Methyl-accepting chemotaxis EPY81_RS00760 ENOG4108ZGA chew protein EPY81_RS00765 ENOG4105M3Z response regulator EPY81_RS00770 ENOG4108UNF response regulator EPY81_RS00795 ENOG4105KWI UPF0339 protein EPY81_RS00800 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EPY81_RS00810 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EPY81_RS00815 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) EPY81_RS00820 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) EPY81_RS00825 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) EPY81_RS00830 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) EPY81_RS00835 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EPY81_RS00840 ENOG4105C2W permease EPY81_RS00860 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EPY81_RS00865 ENOG4105T95 Thiol disulfide interChange protein EPY81_RS00875 ENOG4108N2Y auxin Efflux EPY81_RS00880 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EPY81_RS00885 ENOG4105CHB tonB-dependent Receptor EPY81_RS00890 ENOG4108VX5 3-methyladenine DNA glycosylase EPY81_RS00900 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EPY81_RS00920 ENOG4105C2W permease EPY81_RS00930 ENOG4108IQI permease EPY81_RS00935 ENOG4105E0Y RtcB Protein EPY81_RS00940 ENOG4108WHA ompa motb domain protein EPY81_RS00945 ENOG4105X0D Fimbrial protein EPY81_RS00950 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS00970 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EPY81_RS00975 ENOG4105DZG Dehydrogenase EPY81_RS00980 ENOG4105TW1 Carbohydrate-selective porin OprB EPY81_RS00990 ENOG4108R6W Transcriptional regulator, ARAC family EPY81_RS00995 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS01015 ENOG41082BV acetyltransferase EPY81_RS01025 ENOG4108UT2 hemolysin iii EPY81_RS01030 ENOG4105CSH Transporter EPY81_RS01045 ENOG4105D3R alkyl hydroperoxide reductase EPY81_RS01065 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EPY81_RS01100 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EPY81_RS01110 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) EPY81_RS01115 ENOG4108WBT adenosyltransferase EPY81_RS01135 ENOG4105CNG UPF0061 protein EPY81_RS01145 ENOG4105E3W Two component transcriptional regulator (Winged helix family EPY81_RS01150 ENOG4105EB3 Histidine kinase EPY81_RS01160 ENOG4105CSU acyl-Coa dehydrogenase EPY81_RS01165 ENOG4105CSU acyl-Coa dehydrogenase EPY81_RS01170 ENOG4105EQ2 LysR family Transcriptional regulator EPY81_RS01175 ENOG4108K3A Glutathione S-transferase EPY81_RS01200 ENOG4105UGU tonB-dependent Receptor EPY81_RS01225 ENOG4107S6X Glycosyl transferase, family 2 EPY81_RS01240 ENOG4107BJW polysaccharide deacetylase EPY81_RS01250 ENOG4105CM2 brancheD-chain amino acid aminotransferase EPY81_RS01255 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EPY81_RS01260 ENOG4105BZU Histidine kinase EPY81_RS01295 ENOG4105VIE preprotein translocase, subunit YajC EPY81_RS01300 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EPY81_RS01305 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EPY81_RS01310 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EPY81_RS01320 ENOG4105FFC UPF0187 protein EPY81_RS01335 ENOG4105K9H YciI-like protein EPY81_RS01370 ENOG4105NAU thioesterase Superfamily protein EPY81_RS01380 ENOG4107U2T alpha beta EPY81_RS01385 ENOG4107QPB Beta-lactamase domain protein EPY81_RS01395 ENOG4107QN2 dihydrolipoyl dehydrogenase EPY81_RS01435 ENOG4108WS1 EPY81_RS01440 ENOG4108KHX Diguanylate cyclase EPY81_RS01455 ENOG4107RZC phospholipase d EPY81_RS01465 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EPY81_RS01485 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EPY81_RS01490 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EPY81_RS01495 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EPY81_RS01500 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EPY81_RS01505 ENOG4108UJD 30S ribosomal protein S9 EPY81_RS01510 ENOG4107MKT Stringent starvation protein a EPY81_RS01515 ENOG4105KB2 stringent starvation protein b EPY81_RS01555 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS01560 ENOG4107QX3 carboxylase EPY81_RS01575 ENOG4108RZE Tetr family transcriptional regulator EPY81_RS01580 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS01625 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EPY81_RS01630 ENOG4105D6S protein involved in catabolism of external DNA EPY81_RS01660 ENOG4105E4C Lytic transglycosylase catalytic EPY81_RS01670 ENOG4105C9A Phoh family EPY81_RS01700 ENOG4105CS1 NAD(P)H quinone oxidoreductase EPY81_RS01705 ENOG4107S2Z UPF0761 membrane protein EPY81_RS01710 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EPY81_RS01760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EPY81_RS01765 ENOG4105DGW oligopeptidase A EPY81_RS01770 ENOG4105VKU nucleicacid-binding protein EPY81_RS01805 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS01830 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EPY81_RS01840 ENOG41067V7 50S ribosomal protein L36 EPY81_RS01845 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EPY81_RS01940 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EPY81_RS01945 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EPY81_RS01960 ENOG4105C28 cystathionine EPY81_RS01965 ENOG4105D7A ATP-binding protein EPY81_RS01980 ENOG4105KPV Transcriptional regulator EPY81_RS01995 ENOG4105CK2 sodium dicarboxylate symporter EPY81_RS02000 ENOG4105C29 acyl-CoA thioesterase EPY81_RS02005 ENOG4105E55 glycerol-3-phosphate acyltransferase EPY81_RS02020 ENOG4105CB5 ATP-dependent DNA helicase recG EPY81_RS02025 ENOG4105MJ2 Competence protein EPY81_RS02035 ENOG4108URH decarboxylase EPY81_RS02040 ENOG4105D7N magnesium and cobalt transport protein CorA EPY81_RS02050 ENOG4105E3I toluene tolerance EPY81_RS02060 ENOG4105CY3 ABC transporter, permease EPY81_RS02065 ENOG4105DHJ ABC, transporter EPY81_RS02075 ENOG4105C1J atp-dependent rna helicase EPY81_RS02080 ENOG4105ECY inositol monophosphatase EPY81_RS02095 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EPY81_RS02110 ENOG4105CSU acyl-Coa dehydrogenase EPY81_RS02120 ENOG41067S9 phage shock protein C, PspC EPY81_RS02150 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EPY81_RS02175 ENOG4105BZU Histidine kinase EPY81_RS02205 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EPY81_RS02230 ENOG4105C26 Dehydrogenase EPY81_RS02240 ENOG4105C8Y Acetylornithine aminotransferase EPY81_RS02245 ENOG4105D82 Glutamate dehydrogenase EPY81_RS02250 ENOG4108IQI permease EPY81_RS02280 ENOG4107SKI cobyrinic Acid a,c-diamide synthase EPY81_RS02285 ENOG4105IPI Membrane EPY81_RS02290 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EPY81_RS02295 ENOG4105EM2 membrane EPY81_RS02300 ENOG4107QF7 multi-drug EPY81_RS02310 ENOG4105NF4 modulator of drug activity EPY81_RS02315 ENOG4105VRH Antibiotic biosynthesis monooxygenase EPY81_RS02325 ENOG4105CQB FAD linked oxidase domain protein EPY81_RS02330 ENOG4108JQ1 Dehydrogenase EPY81_RS02335 ENOG4107AQZ Membrane EPY81_RS02340 ENOG4107AQZ Membrane EPY81_RS02355 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EPY81_RS02360 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) EPY81_RS02365 ENOG4107IFA Lipase (EC 3.1.1.3) EPY81_RS02370 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EPY81_RS02380 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EPY81_RS02430 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EPY81_RS02445 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EPY81_RS02450 ENOG4105KME endoribonuclease L-psp EPY81_RS02465 ENOG4108UQY Iron-storage protein EPY81_RS02470 ENOG4108YSG O-Antigen polymerase EPY81_RS02480 ENOG4105KHS type IV fimbrial pilin protein EPY81_RS02490 ENOG4105HA9 of methanol dehydrogenase type EPY81_RS02495 ENOG4108V0P LemA family EPY81_RS02505 ENOG4105BZ8 glutamate synthase EPY81_RS02510 ENOG4105CBC glutamate synthase EPY81_RS02530 ENOG4105E4G Type IV pilus EPY81_RS02555 ENOG4108JQC penicillin-binding protein 1A EPY81_RS02560 ENOG4105DHI Methyltransferase EPY81_RS02575 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EPY81_RS02580 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EPY81_RS02585 ENOG4105CJN penicillin-binding protein EPY81_RS02600 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EPY81_RS02625 ENOG4108IQI permease EPY81_RS02645 ENOG4105DFP Integrase EPY81_RS02805 ENOG4105C5H ABC transporter EPY81_RS02815 ENOG4105PDP Short chain dehydrogenase EPY81_RS02820 ENOG4105CHH sulfate transporter EPY81_RS02830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EPY81_RS02835 ENOG4105E0F Histidine kinase EPY81_RS02845 ENOG4105CYC Transferase EPY81_RS02875 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EPY81_RS02900 ENOG410631K Membrane EPY81_RS02915 ENOG4105CUV Homoserine Kinase EPY81_RS02975 ENOG4108UQN AraC family transcriptional regulator EPY81_RS02980 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain EPY81_RS02990 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EPY81_RS02995 ENOG4105KVH Transcriptional regulator EPY81_RS03035 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) EPY81_RS03040 ENOG4105CPC Aldo Keto reductase EPY81_RS03060 ENOG4106NZI LysR family Transcriptional regulator EPY81_RS03065 ENOG4105D94 Major Facilitator Superfamily EPY81_RS03150 ENOG4105EUB pirin domain protein EPY81_RS03155 ENOG4105CHJ isochorismatase hydrolase EPY81_RS03165 ENOG4105C26 Dehydrogenase EPY81_RS03170 ENOG4108JPW Aminotransferase EPY81_RS03180 ENOG4105C85 amino acid EPY81_RS03190 ENOG4108UMN azlc family EPY81_RS03200 ENOG4108UUM single-stranded DNA-binding protein EPY81_RS03205 ENOG4107RDB Major Facilitator EPY81_RS03215 ENOG4105DWF phosphomethylpyrimidine kinase EPY81_RS03225 ENOG4108IXY short-chain dehydrogenase reductase EPY81_RS03230 ENOG4105RA2 Membrane EPY81_RS03240 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EPY81_RS03245 ENOG4108WUH Transcriptional regulator, TetR family EPY81_RS03250 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EPY81_RS03260 ENOG4105BZU Histidine kinase EPY81_RS03270 ENOG4105C94 Transporter EPY81_RS03280 ENOG4107QN1 sodium solute EPY81_RS03285 ENOG41062QD Membrane EPY81_RS03290 ENOG4105BZU Histidine kinase EPY81_RS03305 ENOG4108UZX fmn reductase EPY81_RS03310 ENOG4105FBW Monooxygenase EPY81_RS03320 ENOG4108W2Y isochorismatase EPY81_RS03325 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EPY81_RS03335 ENOG4105D64 Mechanosensitive ion channel EPY81_RS03345 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EPY81_RS03350 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EPY81_RS03370 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EPY81_RS03385 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EPY81_RS03395 ENOG4105E0K tonB-dependent siderophore receptor EPY81_RS03410 ENOG4107QSN dihydrolipoamide acetyltransferase EPY81_RS03415 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EPY81_RS03420 ENOG41063SB peptidase EPY81_RS03435 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EPY81_RS03440 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EPY81_RS03445 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EPY81_RS03465 ENOG4105D7Z glutathione synthase EPY81_RS03485 ENOG4105CGK Exodeoxyribonuclease III EPY81_RS03490 ENOG4105KUZ arsenate reductase EPY81_RS03505 ENOG4105BZU Histidine kinase EPY81_RS03510 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EPY81_RS03540 ENOG41084YZ Hydrolase EPY81_RS03555 ENOG41061H0 Monooxygenase EPY81_RS03565 ENOG4108Z2U ureidoglycolate hydrolase EPY81_RS03570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPY81_RS03575 ENOG4105IPS esterase EPY81_RS03620 ENOG4105D9M gamma-glutamylcysteine synthetase EPY81_RS03635 ENOG4106BRA Membrane EPY81_RS03640 ENOG4105CHM Aminotransferase EPY81_RS03645 ENOG4107QJQ Mate efflux family protein EPY81_RS03660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EPY81_RS03665 ENOG4105BZU Histidine kinase EPY81_RS03695 ENOG4105KHC sulfurtransferase EPY81_RS03735 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EPY81_RS03750 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EPY81_RS03755 ENOG4108ZAI phosphatidylglycerophosphatase a EPY81_RS03765 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EPY81_RS03800 ENOG41088SP formiminoglutamate hydrolase EPY81_RS03810 ENOG4105C85 amino acid EPY81_RS03825 ENOG41090B9 response to stress EPY81_RS03830 ENOG4105CZE histidine utilization repressor EPY81_RS03840 ENOG4105CKI cobalamin synthesis protein EPY81_RS03850 ENOG4105C85 amino acid EPY81_RS03860 ENOG4108RXX maleylacetoacetate isomerase EPY81_RS03865 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EPY81_RS03880 ENOG4105EWC Purine nucleoside phosphorylase EPY81_RS03885 ENOG4105UQX Mate efflux family protein EPY81_RS03890 ENOG4105C09 Bile acid EPY81_RS03895 ENOG4108RWI nicotinamidase EPY81_RS03900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EPY81_RS03920 ENOG4105S64 Formate nitrite transporter EPY81_RS03925 ENOG4105D1H recombination factor protein RarA EPY81_RS03930 ENOG4105D8V Glucose sorbosone dehydrogenase EPY81_RS03935 ENOG4108ZZ3 UPF0260 protein EPY81_RS03955 ENOG4105CEN a g-specific adenine glycosylase EPY81_RS03970 ENOG4108R3E Dna-3-methyladenine glycosylase i EPY81_RS03975 ENOG4105DQ4 alcohol dehydrogenase EPY81_RS03995 ENOG4105HEI LysR family (Transcriptional regulator EPY81_RS04000 ENOG4105CV8 reductase EPY81_RS04005 ENOG4105F27 Major Facilitator EPY81_RS04040 ENOG4105DJY efflux transporter, rnd family, mfp subunit EPY81_RS04045 ENOG4108IG5 Transcriptional regulator EPY81_RS04055 ENOG4105C2W permease EPY81_RS04085 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EPY81_RS04095 ENOG4105C8J )-transporter EPY81_RS04135 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EPY81_RS04140 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EPY81_RS04155 ENOG4108821 RND type efflux pump EPY81_RS04160 ENOG4108821 RND type efflux pump EPY81_RS04165 ENOG4108821 RND type efflux pump EPY81_RS04170 ENOG4105C5H ABC transporter EPY81_RS04185 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPY81_RS04195 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EPY81_RS04205 ENOG4105VG0 50S ribosomal protein l34 EPY81_RS04220 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EPY81_RS04235 ENOG4105PGM cation diffusion facilitator family transporter EPY81_RS04240 ENOG4105T95 Thiol disulfide interChange protein EPY81_RS04250 ENOG4108UGV hypoxanthine phosphoribosyltransferase EPY81_RS04255 ENOG4107QUY Guanine deaminase EPY81_RS04265 ENOG4106032 Glutathionylspermidine synthase EPY81_RS04275 ENOG4105DU1 integral membrane protein, terc EPY81_RS04280 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EPY81_RS04290 ENOG4105DFU Cell wall formation (By similarity) EPY81_RS04300 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EPY81_RS04305 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EPY81_RS04310 ENOG4105CVE Lytic murein transglycosylase EPY81_RS04365 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EPY81_RS04405 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EPY81_RS04415 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EPY81_RS04420 ENOG4105DTN riboflavin biosynthesis protein ribF EPY81_RS04430 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EPY81_RS04435 ENOG4108R86 Transcriptional regulator EPY81_RS04440 ENOG4108VM9 ABC, transporter EPY81_RS04445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EPY81_RS04450 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EPY81_RS04455 ENOG4105GVF (ABC) transporter EPY81_RS04460 ENOG4105GVF (ABC) transporter EPY81_RS04465 ENOG4107QZM n-acetylglutamate synthase EPY81_RS04480 ENOG4105UBK short-chain dehydrogenase reductase EPY81_RS04485 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EPY81_RS04500 ENOG41062JF Transcriptional regulator EPY81_RS04525 ENOG4105HSS phospholipase C EPY81_RS04535 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EPY81_RS04540 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EPY81_RS04545 ENOG4105CJR Integral membrane protein (MviN EPY81_RS04550 ENOG4108V1T peptidylprolyl cis-trans isomerase EPY81_RS04555 ENOG4108V1T peptidylprolyl cis-trans isomerase EPY81_RS04560 ENOG4105D75 Capsular exopolysaccharide family EPY81_RS04570 ENOG4105DAY polysaccharide export protein EPY81_RS04575 ENOG4107QQG Dehydrogenase EPY81_RS04595 ENOG4105C6Y Udp-glucose 6-dehydrogenase EPY81_RS04600 ENOG4105C1B dTDP-glucose 4-6-dehydratase EPY81_RS04605 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EPY81_RS04610 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EPY81_RS04615 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EPY81_RS04620 ENOG4108SHN Glycosyl transferase, family 2 EPY81_RS04630 ENOG4105H63 Glycosyl transferase, family 2 EPY81_RS04640 ENOG4105D3Q Sugar transferase EPY81_RS04645 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EPY81_RS04650 ENOG4105C6Y Udp-glucose 6-dehydrogenase EPY81_RS04660 ENOG4107QKV phosphomannomutase EPY81_RS04665 ENOG4105DAA L-lactate EPY81_RS04670 ENOG41073TP transcriptional regulator EPY81_RS04680 ENOG4105CXG d-lactate dehydrogenase EPY81_RS04685 ENOG4105CGF Aromatic amino acid aminotransferase EPY81_RS04695 ENOG4105DRR Transcriptional regulator, GntR family EPY81_RS04700 ENOG4105CR4 methylisocitrate lyase EPY81_RS04705 ENOG4105BZN citrate synthase EPY81_RS04710 ENOG4108I0Z Aconitate hydratase EPY81_RS04730 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EPY81_RS04790 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EPY81_RS04810 ENOG4105CIS alcohol dehydrogenase EPY81_RS04815 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EPY81_RS04835 ENOG4105D3G Pseudouridine synthase EPY81_RS04860 ENOG4105EW9 transcriptional regulator AsnC family EPY81_RS04875 ENOG4105M4H endoribonuclease L-psp EPY81_RS04880 ENOG4105C85 amino acid EPY81_RS04885 ENOG4105C85 amino acid EPY81_RS04895 ENOG4105C26 Dehydrogenase EPY81_RS04900 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EPY81_RS04910 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS04915 ENOG4105E39 Enoyl-CoA hydratase EPY81_RS04920 ENOG4105E39 Enoyl-CoA hydratase EPY81_RS04925 ENOG4105CSH Transporter EPY81_RS04930 ENOG4108594 Permease of the drug metabolite transporter EPY81_RS04935 ENOG4105C85 amino acid EPY81_RS04940 ENOG4105CJP fad dependent oxidoreductase EPY81_RS04950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EPY81_RS04970 ENOG4107RCI amp-dependent synthetase and ligase EPY81_RS04975 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS04980 ENOG4105C0W non-ribosomal peptide synthetase EPY81_RS05020 ENOG4107PSF BolA-like protein EPY81_RS05030 ENOG4107QJE Chromosome Partitioning Protein EPY81_RS05045 ENOG4105DQR SNARE associated Golgi EPY81_RS05050 ENOG4108VBZ doxx family EPY81_RS05055 ENOG4106MP8 UPF0754 membrane protein EPY81_RS05060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EPY81_RS05075 ENOG4105EUB pirin domain protein EPY81_RS05100 ENOG4107R1I NAD-dependent malic enzyme EPY81_RS05105 ENOG4105EZR dyp-type peroxidase family protein EPY81_RS05115 ENOG4105FAV ABC, transporter EPY81_RS05120 ENOG4105FDK ABC transporter EPY81_RS05145 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EPY81_RS05160 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EPY81_RS05170 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EPY81_RS05185 ENOG4108V06 Glutathione peroxidase EPY81_RS05195 ENOG4107RTG Major Facilitator superfamily EPY81_RS05200 ENOG4108IND Tetr family transcriptional regulator EPY81_RS05215 ENOG4105C79 DNA protecting protein DprA EPY81_RS05250 ENOG4105Y7M Transcriptional regulator, TetR family EPY81_RS05280 ENOG4105C6T cysteine synthase EPY81_RS05295 ENOG4105CS1 NAD(P)H quinone oxidoreductase EPY81_RS05315 ENOG4105CCT upf0313 protein EPY81_RS05335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EPY81_RS05345 ENOG4105C0R drug resistance transporter emrb qaca subfamily EPY81_RS05350 ENOG4108URH decarboxylase EPY81_RS05355 ENOG4105EE5 Membrane protein terC EPY81_RS05360 ENOG4105K5B UPF0225 protein EPY81_RS05365 ENOG4105EN6 Membrane EPY81_RS05370 ENOG41079KZ Major Facilitator Superfamily EPY81_RS05375 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPY81_RS05380 ENOG4105CEY Amp-dependent synthetase and ligase EPY81_RS05395 ENOG4105F0N pyrophosphate phospho-hydrolase EPY81_RS05400 ENOG41090KI Outer membrane porin EPY81_RS05415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EPY81_RS05420 ENOG4105FB2 class II Aldolase EPY81_RS05425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EPY81_RS05430 ENOG4108YYH Nadph-dependent fmn reductase EPY81_RS05435 ENOG4105C0P Mg chelatase subunit ChlI EPY81_RS05450 ENOG4105BZU Histidine kinase EPY81_RS05460 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EPY81_RS05500 ENOG4108K5H permease YjgP YjgQ family protein EPY81_RS05505 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EPY81_RS05510 ENOG4105CN1 protease EPY81_RS05515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EPY81_RS05520 ENOG4107TUY Histidine kinase EPY81_RS05530 ENOG41061WM D-Alanyl-D-Alanine EPY81_RS05540 ENOG4105D6E homoserine dehydrogenase EPY81_RS05545 ENOG4105T95 Thiol disulfide interChange protein EPY81_RS05550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EPY81_RS05560 ENOG4105CE1 Ferrous iron transport protein b EPY81_RS05575 ENOG4105CNI cell division protein FtsW EPY81_RS05580 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EPY81_RS05585 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters EPY81_RS05590 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EPY81_RS05595 ENOG41087AY ADP-Ribose pyrophosphatase EPY81_RS05615 ENOG4108RNG Permease of the drug metabolite transporter EPY81_RS05625 ENOG4105DFG type I secretion outer membrane protein EPY81_RS05630 ENOG4108UTW Plays a role in the regulation of phosphate uptake EPY81_RS05645 ENOG4108HRK Histidine kinase EPY81_RS05650 ENOG4108NEV two component transcriptional regulator, LytTR family EPY81_RS05655 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EPY81_RS05680 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS EPY81_RS05695 ENOG4105GVR general secretion pathway protein D EPY81_RS05700 ENOG4105TV9 FHA Domain-Containing protein EPY81_RS05705 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EPY81_RS05735 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EPY81_RS05745 ENOG4105PM1 preprotein translocase subunit SecE EPY81_RS05750 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EPY81_RS05805 ENOG4105D3Y Na H antiporter EPY81_RS05820 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EPY81_RS05835 ENOG4107ZXU DSBA oxidoreductase EPY81_RS05845 ENOG4108Z6Z Transcriptional regulator EPY81_RS05900 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EPY81_RS05905 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EPY81_RS05940 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EPY81_RS05950 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EPY81_RS05965 ENOG4105C2N RNA methyltransferase TrmH family group 3 EPY81_RS05975 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EPY81_RS05990 ENOG4107QHF type ii secretion system protein e EPY81_RS06000 ENOG4107EJC Preprotein translocase subunit SecG EPY81_RS06025 ENOG4105CHV Transcription elongation factor NusA EPY81_RS06035 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EPY81_RS06040 ENOG4105KJM monovalent cation h antiporter subunit g EPY81_RS06045 ENOG4105W4C monovalent cation H antiporter subunit F EPY81_RS06050 ENOG4105SC1 monovalent cation H antiporter subunit E EPY81_RS06055 ENOG4107R4Z monovalent cation h antiporter subunit d EPY81_RS06060 ENOG4108ZE9 Monovalent cation H antiporter subunit C EPY81_RS06065 ENOG4105D65 subunit l EPY81_RS06085 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase EPY81_RS06090 ENOG41061H0 Monooxygenase EPY81_RS06105 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EPY81_RS06115 ENOG4105CSR polyphosphate kinase 2 EPY81_RS06125 ENOG4105DSY exodeoxyribonuclease V, gamma EPY81_RS06130 ENOG4107QKA exodeoxyribonuclease V beta EPY81_RS06135 ENOG4107QYX exodeoxyribonuclease v alpha EPY81_RS06150 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EPY81_RS06155 ENOG4107QUT magnesium and cobalt transport protein CorA EPY81_RS06160 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) EPY81_RS06165 ENOG4105DVC DnaJ domain protein EPY81_RS06175 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EPY81_RS06185 ENOG4105C25 Primosomal protein n' EPY81_RS06190 ENOG4105D7Q type ii secretion system EPY81_RS06195 ENOG4108VAU general secretion pathway protein G EPY81_RS06205 ENOG4108Z7R Chaperone CsaA EPY81_RS06210 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EPY81_RS06215 ENOG4108JU5 Magnesium and cobalt efflux protein EPY81_RS06220 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) EPY81_RS06230 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EPY81_RS06240 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EPY81_RS06255 ENOG4105C5X domain protein EPY81_RS06260 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) EPY81_RS06270 ENOG4105BZ8 glutamate synthase EPY81_RS06300 ENOG4107T8P acyl-Coa dehydrogenase EPY81_RS06310 ENOG4107QI1 Mate efflux family protein EPY81_RS06320 ENOG4105CSA Coproporphyrinogen iii oxidase EPY81_RS06330 ENOG4105CBN LysR family transcriptional regulator EPY81_RS06350 ENOG4105C03 ribonuclease EPY81_RS06355 ENOG4105EI2 Pseudouridine synthase EPY81_RS06360 ENOG4107XGZ Hydrolase EPY81_RS06365 ENOG4105D29 Helix-turn-helix type 11 domain protein EPY81_RS06380 ENOG4108W5M transcriptional regulator EPY81_RS06395 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EPY81_RS06445 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EPY81_RS06500 ENOG4105CK2 sodium dicarboxylate symporter EPY81_RS06510 ENOG4105D1S lipid A biosynthesis EPY81_RS06520 ENOG4105C5H ABC transporter EPY81_RS06525 ENOG41069P5 Protein slyX homolog EPY81_RS06535 ENOG4105KVH Transcriptional regulator EPY81_RS06545 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EPY81_RS06560 ENOG4105C4R Atp-dependent dna helicase EPY81_RS06565 ENOG4105VFU Rna-binding protein EPY81_RS06585 ENOG4105CKD glutathione-regulated potassium-efflux system protein EPY81_RS06590 ENOG4105W0E 50S ribosomal protein L33 EPY81_RS06595 ENOG4105KDC 50s ribosomal protein l28 EPY81_RS06600 ENOG4107RGH Aldehyde dehydrogenase EPY81_RS06610 ENOG4105CIY formyltetrahydrofolate deformylase EPY81_RS06710 ENOG4105DWV Homoserine O-trans-acetylase EPY81_RS06720 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EPY81_RS06730 ENOG4108ESX Receptor EPY81_RS06740 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EPY81_RS06760 ENOG4107GFK fumarate EPY81_RS06765 ENOG4108DNC Involved in acetate metabolism (By similarity) EPY81_RS06770 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EPY81_RS06780 ENOG4105C01 Dihydroxy-acid dehydratase EPY81_RS06785 ENOG4108UHU Aldolase EPY81_RS06790 ENOG4105C6Z Gluconate EPY81_RS06795 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EPY81_RS06800 ENOG4105C26 Dehydrogenase EPY81_RS06810 ENOG4106HB6 Alpha beta hydrolase EPY81_RS06825 ENOG4105CN1 protease EPY81_RS06840 ENOG4105WVQ Fe-S assembly protein IscX EPY81_RS06860 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) EPY81_RS06880 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EPY81_RS06900 ENOG4105VW4 glutaredoxin 3 EPY81_RS06910 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EPY81_RS06915 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EPY81_RS06925 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EPY81_RS06940 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EPY81_RS06945 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EPY81_RS06950 ENOG4105DJY efflux transporter, rnd family, mfp subunit EPY81_RS06970 ENOG4105C7K acetolactate synthase EPY81_RS06975 ENOG4108ZP8 Acetolactate synthase small subunit EPY81_RS06980 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EPY81_RS06985 ENOG4105BZU Histidine kinase EPY81_RS07000 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EPY81_RS07015 ENOG4105F8V Hydrolase, tatD family EPY81_RS07020 ENOG4107QM5 aconitate hydratase EPY81_RS07025 ENOG4105CUZ uba thif-type nad fad binding protein EPY81_RS07035 ENOG4107RSM transcriptional regulator EPY81_RS07050 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EPY81_RS07130 ENOG4105C59 p-type ATPase EPY81_RS07135 ENOG4105GR3 Histidine kinase EPY81_RS07150 ENOG4105E3B Multicopper oxidase EPY81_RS07175 ENOG4108IJF Heavy metal efflux pump, CzcA EPY81_RS07185 ENOG4105CE1 Ferrous iron transport protein b EPY81_RS07200 ENOG4105W1Y Transcriptional regulator EPY81_RS07245 ENOG4106UX7 integral membrane protein EPY81_RS07250 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EPY81_RS07255 ENOG4105W8H transhydrogenase (subunit alpha EPY81_RS07260 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EPY81_RS07280 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EPY81_RS07285 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EPY81_RS07290 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase EPY81_RS07295 ENOG4105BZU Histidine kinase EPY81_RS07300 ENOG4105C6T cysteine synthase EPY81_RS07315 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EPY81_RS07320 ENOG4105EMU Dehydrogenase EPY81_RS07325 ENOG4105DXN mazG family EPY81_RS07330 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EPY81_RS07335 ENOG4105DJ0 Poly(A) Polymerase EPY81_RS07340 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EPY81_RS07360 ENOG41080Z8 PHOSPHOCARRIER protein EPY81_RS07365 ENOG4105N42 UPF0307 protein EPY81_RS07370 ENOG4105CEY Amp-dependent synthetase and ligase EPY81_RS07385 ENOG4105CYM Glutathione S-transferase EPY81_RS07390 ENOG4105W39 Membrane EPY81_RS07405 ENOG41082NX 50s ribosomal protein l35 EPY81_RS07410 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EPY81_RS07430 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EPY81_RS07450 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EPY81_RS07460 ENOG4105C9X ppx gppa phosphatase EPY81_RS07470 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EPY81_RS07475 ENOG4105II7 pyrroline-5-carboxylate reductase EPY81_RS07480 ENOG4108VIA integral membrane protein EPY81_RS07485 ENOG4105C2M dna polymerase I EPY81_RS07505 ENOG4107QHF type ii secretion system protein e EPY81_RS07510 ENOG4108ZHJ Organic hydroperoxide resistance protein EPY81_RS07515 ENOG4105K56 Transcriptional regulator EPY81_RS07585 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EPY81_RS07590 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EPY81_RS07595 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EPY81_RS07650 ENOG4108Z0R Transferase EPY81_RS07655 ENOG41072GX Peptidase M22 Glycoprotease EPY81_RS07680 ENOG4105DJV ribulose-phosphate 3-epimerase EPY81_RS07685 ENOG4108HCJ Hydrolase EPY81_RS07695 ENOG4105E3B Multicopper oxidase EPY81_RS07715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EPY81_RS07720 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EPY81_RS07725 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EPY81_RS07750 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EPY81_RS07760 ENOG4105ETT transcriptional Regulator, LysR family EPY81_RS07765 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS07770 ENOG4107RGD Major Facilitator superfamily EPY81_RS07775 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EPY81_RS07800 ENOG4107EFR Flavocytochrome c EPY81_RS07805 ENOG4106P55 Transcriptional regulator EPY81_RS07830 ENOG4106P55 Transcriptional regulator EPY81_RS07870 ENOG4105ETT transcriptional Regulator, LysR family EPY81_RS07880 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EPY81_RS07885 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EPY81_RS07950 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) EPY81_RS07955 ENOG4105EQK -acetyltransferase EPY81_RS07995 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EPY81_RS08005 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EPY81_RS08010 ENOG4107EXC regulatoR EPY81_RS08015 ENOG4105E0F Histidine kinase EPY81_RS08025 ENOG4105BZU Histidine kinase EPY81_RS08045 ENOG4105GKE subunit e EPY81_RS08050 ENOG4107QIZ NADH dehydrogenase EPY81_RS08055 ENOG4108IEH NADH dehydrogenase subunit g EPY81_RS08070 ENOG4107UFS subunit j EPY81_RS08080 ENOG4105D65 subunit l EPY81_RS08085 ENOG4105C8S subunit m EPY81_RS08105 ENOG4105DUM transcriptional regulator, lysR family EPY81_RS08110 ENOG4105DP0 ferredoxin-NADP reductase EPY81_RS08135 ENOG4105CBX hi0933 family EPY81_RS08140 ENOG4105K6H D-cysteine desulfhydrase EPY81_RS08175 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EPY81_RS08185 ENOG4105D1F ATP-binding protein EPY81_RS08190 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EPY81_RS08235 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) EPY81_RS08245 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EPY81_RS08260 ENOG4105HF0 Membrane EPY81_RS08270 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EPY81_RS08290 ENOG4106UW1 Major Facilitator superfamily EPY81_RS08295 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase EPY81_RS08300 ENOG4108K4C ec 3.1.3.12 EPY81_RS08305 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EPY81_RS08315 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EPY81_RS08320 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EPY81_RS08330 ENOG4105FE9 pseudouridine synthase EPY81_RS08335 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EPY81_RS08340 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EPY81_RS08345 ENOG4107RTD sua5 ycio yrdc ywlc family protein EPY81_RS08350 ENOG4108BPE -transporting atpase EPY81_RS08355 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EPY81_RS08365 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EPY81_RS08370 ENOG4105CHR reductase EPY81_RS08380 ENOG4109066 lysm domain bon superfamily protein EPY81_RS08385 ENOG4105DWF phosphomethylpyrimidine kinase EPY81_RS08395 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EPY81_RS08425 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EPY81_RS08455 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) EPY81_RS08470 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EPY81_RS08475 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EPY81_RS08480 ENOG4105C34 Pseudouridine synthase EPY81_RS08485 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EPY81_RS08505 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EPY81_RS08525 ENOG4105EJC lysr family transcriptional regulator EPY81_RS08530 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EPY81_RS08535 ENOG4105C94 Transporter EPY81_RS08545 ENOG4105DVW rieske (2Fe-2S) EPY81_RS08550 ENOG4105C26 Dehydrogenase EPY81_RS08555 ENOG4105E3J oxidoreductase EPY81_RS08570 ENOG4105C4K Nad synthetase EPY81_RS08580 ENOG4108YXA Membrane EPY81_RS08595 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EPY81_RS08605 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EPY81_RS08610 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EPY81_RS08625 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EPY81_RS08635 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EPY81_RS08640 ENOG4105C3M thioredoxin reductase EPY81_RS08645 ENOG4105CNU cell division protein FtsK EPY81_RS08665 ENOG4107QMS site-determining protein EPY81_RS08680 ENOG4106HNH Acyl-transferase EPY81_RS08685 ENOG4108ZG0 Ompa motb domain protein EPY81_RS08690 ENOG4105C4R Atp-dependent dna helicase EPY81_RS08700 ENOG4107QKV phosphomannomutase EPY81_RS08715 ENOG4105E7A Glutamine amidotransferase EPY81_RS08730 ENOG4105VDB UPF0125 protein EPY81_RS08740 ENOG41090R7 Ferric uptake EPY81_RS08745 ENOG4105CZX twitching motility protein EPY81_RS08750 ENOG4105CZX twitching motility protein EPY81_RS08755 ENOG4105DFA alanine racemase domain protein EPY81_RS08760 ENOG4105EYH Exonuclease EPY81_RS08765 ENOG4107RH8 nuclease SbcCD subunit D EPY81_RS08785 ENOG4105ECP epimerase EPY81_RS08790 ENOG4105MWK D-amino acid dehydrogenase, small subunit EPY81_RS08795 ENOG4105D52 delta-aminolevulinic acid dehydratase EPY81_RS08800 ENOG4108VUY thioesterase Superfamily protein EPY81_RS08805 ENOG4105CW7 secretion protein, HlyD family EPY81_RS08810 ENOG4105C0R drug resistance transporter emrb qaca subfamily EPY81_RS08815 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EPY81_RS08825 ENOG4105DFP Integrase EPY81_RS08885 ENOG4105CVR type I restriction-modification system EPY81_RS08900 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 EPY81_RS08970 ENOG4105C54 Major Facilitator superfamily EPY81_RS08975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EPY81_RS09025 ENOG4105D5Q Arginine ornithine antiporter EPY81_RS09030 ENOG4107QK5 Homocysteine s-methyltransferase EPY81_RS09055 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EPY81_RS09060 ENOG4105C94 Transporter EPY81_RS09065 ENOG4105C94 Transporter EPY81_RS09085 ENOG4105CKI cobalamin synthesis protein EPY81_RS09095 ENOG4108VWS Yaeq family EPY81_RS09105 ENOG4107BJW polysaccharide deacetylase EPY81_RS09110 ENOG4105CND Glycosyl transferase, family 2 EPY81_RS09135 ENOG41069M3 Transcriptional regulator EPY81_RS09155 ENOG4105CHR reductase EPY81_RS09165 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase EPY81_RS09170 ENOG4105DJB Major Facilitator Superfamily EPY81_RS09180 ENOG4108MXF Alpha Beta Hydrolase EPY81_RS09185 ENOG4105CHR reductase EPY81_RS09200 ENOG4105C7K acetolactate synthase EPY81_RS09210 ENOG4105CSH Transporter EPY81_RS09215 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EPY81_RS09220 ENOG4105CSV Glutaminase EPY81_RS09225 ENOG4105FTV AraC Family Transcriptional Regulator EPY81_RS09230 ENOG4105EU0 Major facilitator Superfamily EPY81_RS09235 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EPY81_RS09245 ENOG4108PZW LysR family Transcriptional regulator EPY81_RS09255 ENOG4105CSP Major Facilitator Superfamily EPY81_RS09270 ENOG4105C3R Methionine synthase EPY81_RS09275 ENOG4105CJ3 phosphate transporter EPY81_RS09295 ENOG4105E6M Sulphatase-modifying factor protein EPY81_RS09300 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) EPY81_RS09315 ENOG4107RNH Outer membrane receptor FepA EPY81_RS09335 ENOG4108UJV acyl-CoA thioesterase i EPY81_RS09340 ENOG4108I0Y (ABC) transporter EPY81_RS09345 ENOG4105CV6 ABC transporter, permease EPY81_RS09350 ENOG4107U91 Rhomboid family EPY81_RS09375 ENOG4105C5Q Transcriptional regulator EPY81_RS09380 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EPY81_RS09385 ENOG4107QZF nitrite reductase NADPH large subunit EPY81_RS09390 ENOG4105VCQ rubredoxin EPY81_RS09410 ENOG4108MRJ EPY81_RS09425 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) EPY81_RS09440 ENOG4105D4T Citrate transporter EPY81_RS09445 ENOG4105C37 (CBS) domain EPY81_RS09455 ENOG4107RET Isocitrate lyase EPY81_RS09460 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion EPY81_RS09485 ENOG4105CQM Urea amidohydrolase subunit alpha EPY81_RS09495 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EPY81_RS09510 ENOG4106H78 methyltransferase EPY81_RS09515 ENOG4105CJN penicillin-binding protein EPY81_RS09540 ENOG4105CSM endonuclease III EPY81_RS09545 ENOG4108R3D Electron transport complex EPY81_RS09550 ENOG4105D82 Glutamate dehydrogenase EPY81_RS09560 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EPY81_RS09575 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EPY81_RS09615 ENOG4107RAQ aminopeptidase EPY81_RS09620 ENOG4105D0A hydroxylase EPY81_RS09625 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EPY81_RS09635 ENOG4105W1Y Transcriptional regulator EPY81_RS09645 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EPY81_RS09660 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EPY81_RS09670 ENOG4105W4M Transport-associated protein EPY81_RS09680 ENOG4105E09 nadh pyrophosphatase EPY81_RS09690 ENOG4108JDX DNA polymerase iii, epsilon subunit EPY81_RS09695 ENOG4105E9H Lytic Murein transglycosylase EPY81_RS09695 ENOG4105E9H Lytic Murein transglycosylase EPY81_RS09700 ENOG4105E43 Extracellular solute-binding protein, family 5 EPY81_RS09705 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EPY81_RS09710 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EPY81_RS09715 ENOG4108JQ5 ABC transporter EPY81_RS09740 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) EPY81_RS09760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EPY81_RS09770 ENOG4105DFP Integrase EPY81_RS09875 ENOG4107Y80 Major Facilitator superfamily EPY81_RS09890 ENOG4105PGM cation diffusion facilitator family transporter EPY81_RS09900 ENOG4105CAH Chromate EPY81_RS09930 ENOG4108M3P Membrane EPY81_RS09950 ENOG4106B0W Curli production assembly transport component CsgG EPY81_RS09960 ENOG4107Y60 (LipO)protein EPY81_RS09970 ENOG4105C85 amino acid EPY81_RS09980 ENOG4105CUB amino acid EPY81_RS10000 ENOG4105C26 Dehydrogenase EPY81_RS10020 ENOG4105C85 amino acid EPY81_RS10025 ENOG4105D5K Hemolysin activator protein EPY81_RS10030 ENOG4105CKT filamentous hemagglutinin EPY81_RS10040 ENOG4107RGH Aldehyde dehydrogenase EPY81_RS10045 ENOG4108ZX5 transcriptional regulator EPY81_RS10050 ENOG4105DJP Membrane EPY81_RS10055 ENOG4105CTX dehydratase EPY81_RS10060 ENOG4105DJB Major Facilitator Superfamily EPY81_RS10065 ENOG4105EQX glucarate dehydratase EPY81_RS10075 ENOG4105CZJ Aldehyde dehydrogenase EPY81_RS10080 ENOG4105JXH GntR family transcriptional regulator EPY81_RS10095 ENOG4105NI3 Protein of unknown function (DUF3237) EPY81_RS10100 ENOG4105EPF Outer membrane porin EPY81_RS10105 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS10120 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase EPY81_RS10125 ENOG4108SC4 )-transporter EPY81_RS10145 ENOG4105E3J oxidoreductase EPY81_RS10160 ENOG4105E6M Sulphatase-modifying factor protein EPY81_RS10165 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) EPY81_RS10170 ENOG4105D2S major facilitator superfamily EPY81_RS10175 ENOG4105EPF Outer membrane porin EPY81_RS10180 ENOG4105DDY UPF0142 protein ycaO EPY81_RS10200 ENOG4107RN6 Monooxygenase EPY81_RS10210 ENOG4105JQZ Methyltransferase EPY81_RS10215 ENOG4105F95 Monooxygenase EPY81_RS10245 ENOG4105C7N Xanthine uracil vitamin C permease EPY81_RS10250 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EPY81_RS10255 ENOG4105CPW cytochrome b561 EPY81_RS10265 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EPY81_RS10275 ENOG4105CFH Aspartokinase EPY81_RS10325 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EPY81_RS10330 ENOG4105W7J DNA binding EPY81_RS10430 ENOG4107ZQ5 Phage-associated protein, HI1409 family EPY81_RS10450 ENOG41090AG Bacteriophage protein EPY81_RS10555 ENOG4105DIJ Phosphoethanolamine transferase EPY81_RS10570 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EPY81_RS10585 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EPY81_RS10600 ENOG4105CPC Aldo Keto reductase EPY81_RS10605 ENOG4107RYR Transcriptional regulator, Crp Fnr family EPY81_RS10615 ENOG4108UKZ OsmC family EPY81_RS10630 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EPY81_RS10660 ENOG4105CD3 dihydroorotase EPY81_RS10665 ENOG4108ZG0 Ompa motb domain protein EPY81_RS10675 ENOG4108TGY Glutathione S-transferase EPY81_RS10705 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EPY81_RS10715 ENOG4108K3A Glutathione S-transferase EPY81_RS10725 ENOG4108JU3 Alkyl hydroperoxide reductase EPY81_RS10745 ENOG4105D3R alkyl hydroperoxide reductase EPY81_RS10750 ENOG4105CQ7 ATP-dependent helicase EPY81_RS10765 ENOG4105D2S major facilitator superfamily EPY81_RS10770 ENOG4105DKK Benzoate EPY81_RS10775 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase EPY81_RS10780 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein EPY81_RS10785 ENOG4108UKV benzoate 1,2-dioxygenase EPY81_RS10790 ENOG4105FUY alpha subunit EPY81_RS10800 ENOG4108KB2 LysR family Transcriptional regulator EPY81_RS10810 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein EPY81_RS10830 ENOG4105EUV Phenol 2-monooxygenase EPY81_RS10895 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EPY81_RS10945 ENOG4105D1S lipid A biosynthesis EPY81_RS10950 ENOG4105VEQ Cold shock protein EPY81_RS10960 ENOG4105II7 pyrroline-5-carboxylate reductase EPY81_RS10970 ENOG4105EW9 transcriptional regulator AsnC family EPY81_RS10975 ENOG4105PAD Hydrolase EPY81_RS10980 ENOG4105F2W methyltransferase EPY81_RS11005 ENOG4105R8C Transcriptional regulator EPY81_RS11050 ENOG4105CUY Mechanosensitive ion channel EPY81_RS11065 ENOG4107YPT transcriptional regulator EPY81_RS11110 ENOG4105C2X Arabinose 5-phosphate isomerase EPY81_RS11115 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EPY81_RS11125 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA EPY81_RS11130 ENOG4108IUZ ABC transporter EPY81_RS11135 ENOG4105DFG type I secretion outer membrane protein EPY81_RS11145 ENOG4105C42 Type I secretion membrane fusion protein (HlyD EPY81_RS11165 ENOG4107ZBN O-methyltransferase EPY81_RS11175 ENOG4108Z4U Ferredoxin EPY81_RS11195 ENOG4108ZX5 transcriptional regulator EPY81_RS11205 ENOG4105CRN Aminoglycoside phosphotransferase EPY81_RS11210 ENOG4105D5Q Arginine ornithine antiporter EPY81_RS11230 ENOG4105CD3 dihydroorotase EPY81_RS11240 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) EPY81_RS11255 ENOG4105KVH Transcriptional regulator EPY81_RS11260 ENOG4107VGR Catalase EPY81_RS11265 ENOG4105CPW cytochrome b561 EPY81_RS11270 ENOG4105D2S major facilitator superfamily EPY81_RS11295 ENOG4105BZU Histidine kinase EPY81_RS11370 ENOG4105E18 UPF0276 protein EPY81_RS11380 ENOG4108WQI RNA Polymerase EPY81_RS11395 ENOG4105C5A transporter EPY81_RS11415 ENOG4108JIK carboxylase EPY81_RS11420 ENOG4107R4J Chloride channel EPY81_RS11425 ENOG4105D5K Hemolysin activator protein EPY81_RS11430 ENOG4105CKT filamentous hemagglutinin EPY81_RS11460 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) EPY81_RS11465 ENOG4105E2A Dehydrogenase EPY81_RS11480 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EPY81_RS11485 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF EPY81_RS11500 ENOG4105MRR Transcriptional regulator (By similarity) EPY81_RS11510 ENOG4108HW3 (ABC) transporter EPY81_RS11530 ENOG4105C0R drug resistance transporter emrb qaca subfamily EPY81_RS11535 ENOG4105JQN Transcriptional regulator EPY81_RS11560 ENOG4105EMY transcriptional regulator EPY81_RS11570 ENOG4107Y2X deaminase EPY81_RS11575 ENOG4105DJ2 Major Facilitator Superfamily EPY81_RS11590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EPY81_RS11595 ENOG4105WPN DNA integration recombination invertion protein EPY81_RS11605 ENOG4108Z4X TRANSCRIPTIONal EPY81_RS11625 ENOG4105EJQ L-serine dehydratase EPY81_RS11630 ENOG4105DXM phenylacetic acid degradation protein EPY81_RS11635 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit EPY81_RS11640 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit EPY81_RS11645 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit EPY81_RS11650 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit EPY81_RS11655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EPY81_RS11660 ENOG4105E39 Enoyl-CoA hydratase EPY81_RS11665 ENOG4108UKI Enoyl-CoA hydratase EPY81_RS11670 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EPY81_RS11675 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS11680 ENOG4105DZS Phenylacetate-CoA ligase EPY81_RS11685 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein EPY81_RS11695 ENOG4107YAU phenylacetic acid degradation protein EPY81_RS11730 ENOG4105HEI LysR family (Transcriptional regulator EPY81_RS11740 ENOG4107HP6 Transcriptional regulator EPY81_RS11745 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase EPY81_RS11765 ENOG4105C4Y ABC transporter EPY81_RS11770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EPY81_RS11775 ENOG4107RCV ABC transporter, permease EPY81_RS11785 ENOG4107STF Involved in phosphonate degradation (By similarity) EPY81_RS11790 ENOG4108KAZ Involved in phosphonate degradation (By similarity) EPY81_RS11795 ENOG4107RGD Major Facilitator superfamily EPY81_RS11800 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS11815 ENOG4108UKI Enoyl-CoA hydratase EPY81_RS11820 ENOG4105EA8 2-Nitropropane dioxygenase EPY81_RS11825 ENOG4105EQ0 Major Facilitator superfamily EPY81_RS11835 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS11840 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EPY81_RS11845 ENOG4105CHR reductase EPY81_RS11850 ENOG4105E39 Enoyl-CoA hydratase EPY81_RS11855 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS11860 ENOG4107RGD Major Facilitator superfamily EPY81_RS11865 ENOG4107QP7 CoA-transferase subunit A EPY81_RS11870 ENOG4107QNJ CoA-transferase subunit B EPY81_RS11880 ENOG4105EQ0 Major Facilitator superfamily EPY81_RS11890 ENOG4105CSU acyl-Coa dehydrogenase EPY81_RS11905 ENOG4105CC0 LysR family Transcriptional regulator EPY81_RS11920 ENOG4105E39 Enoyl-CoA hydratase EPY81_RS11925 ENOG4107QX3 carboxylase EPY81_RS11930 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS11935 ENOG4105R8C Transcriptional regulator EPY81_RS11940 ENOG4105CEY Amp-dependent synthetase and ligase EPY81_RS11955 ENOG4105D2S major facilitator superfamily EPY81_RS11965 ENOG4105HEI LysR family (Transcriptional regulator EPY81_RS12020 ENOG4105K70 DNA-binding protein EPY81_RS12110 ENOG4105CF2 Mu-like prophage FluMu protein GP28 EPY81_RS12115 ENOG4105QIB mu-like prophage Flumu protein gp29 EPY81_RS12120 ENOG4108QUU Morphogenesis Protein EPY81_RS12255 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EPY81_RS12275 ENOG4105KT5 UmuD protein EPY81_RS12285 ENOG4105EW9 transcriptional regulator AsnC family EPY81_RS12295 ENOG4105BZU Histidine kinase EPY81_RS12300 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EPY81_RS12315 ENOG4105EAD ABC transporter EPY81_RS12320 ENOG4108HW4 amino acid AbC transporter EPY81_RS12330 ENOG4107RP9 extracellular solute-binding protein, family 3 EPY81_RS12335 ENOG4105CT1 (ABC) transporter EPY81_RS12340 ENOG4105EXG Transcriptional regulator EPY81_RS12355 ENOG4105C9B Cysteine desulfurase EPY81_RS12360 ENOG4105ESN nucleotide-binding protein EPY81_RS12365 ENOG4105D7W serine acetyltransferase EPY81_RS12375 ENOG4105CHR reductase EPY81_RS12380 ENOG4105CBN LysR family transcriptional regulator EPY81_RS12400 ENOG4105CYM Glutathione S-transferase EPY81_RS12405 ENOG4108SHQ Glutathione S-transferase EPY81_RS12410 ENOG4105CMU LysR family (Transcriptional regulator EPY81_RS12415 ENOG4105VAW lrga family EPY81_RS12420 ENOG41067MG lrgb family EPY81_RS12445 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase EPY81_RS12450 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) EPY81_RS12465 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase EPY81_RS12470 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EPY81_RS12485 ENOG4108K70 Transcriptional regulator EPY81_RS12490 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EPY81_RS12500 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EPY81_RS12505 ENOG4105C4M (Ubiquinol oxidase) subunit I EPY81_RS12525 ENOG4105C54 Major Facilitator superfamily EPY81_RS12535 ENOG4106FTQ Taurine ABC transporter, periplasmic EPY81_RS12540 ENOG4108IY8 ABC, transporter EPY81_RS12545 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EPY81_RS12550 ENOG4105E2B Taurine dioxygenase EPY81_RS12560 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EPY81_RS12570 ENOG4105CBN LysR family transcriptional regulator EPY81_RS12580 ENOG4105CPN adenine deaminase EPY81_RS12595 ENOG41082YX Transcriptional regulator, arsr family EPY81_RS12605 ENOG4105D6J arsenicaL-resistance protein EPY81_RS12610 ENOG4105CAU Arsenical resistance protein, ArsH EPY81_RS12615 ENOG4108KB2 LysR family Transcriptional regulator EPY81_RS12630 ENOG4108JU3 Alkyl hydroperoxide reductase EPY81_RS12655 ENOG4105C0B DNA polymerase III (alpha subunit) EPY81_RS12665 ENOG4105CK2 sodium dicarboxylate symporter EPY81_RS12670 ENOG4105CHM Aminotransferase EPY81_RS12680 ENOG4108V06 Glutathione peroxidase EPY81_RS12685 ENOG4105E7U AraC family transcriptional regulator EPY81_RS12715 ENOG4105ZED uncharacterized protein ygaH EPY81_RS12720 ENOG4108UMN azlc family EPY81_RS12745 ENOG4105C3G gtp-binding protein EPY81_RS12750 ENOG4108UMI ABC transporter, permease EPY81_RS12755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EPY81_RS12760 ENOG4105D01 (LipO)protein EPY81_RS12765 ENOG4105D01 (LipO)protein EPY81_RS12780 ENOG4107T8P acyl-Coa dehydrogenase EPY81_RS12795 ENOG4105EAD ABC transporter EPY81_RS12800 ENOG4105DRP amino acid AbC transporter EPY81_RS12805 ENOG4105CDA abc transporter atp-binding protein EPY81_RS12815 ENOG4105EW9 transcriptional regulator AsnC family EPY81_RS12830 ENOG41067SE Tetr family transcriptional regulator EPY81_RS12845 ENOG4105CC0 LysR family Transcriptional regulator EPY81_RS12855 ENOG4105ETS cytosine purines uracil thiamine allantoin EPY81_RS12865 ENOG4108IPJ Membrane EPY81_RS12870 ENOG4108R4R Iron-regulated virulence regulatory protein EPY81_RS12905 ENOG4105X0I Fimbrial EPY81_RS12925 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EPY81_RS12930 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EPY81_RS12950 ENOG4108HWY Beta-lactamase EPY81_RS12975 ENOG4105CV1 Transketolase (EC 2.2.1.1) EPY81_RS12985 ENOG4108YYC ycei family EPY81_RS12995 ENOG4108T58 Mg2 transport protein CorA EPY81_RS13010 ENOG4105YGK Pfam:UPF0157 EPY81_RS13015 ENOG4105C26 Dehydrogenase EPY81_RS13020 ENOG4105EW9 transcriptional regulator AsnC family EPY81_RS13025 ENOG4105CK7 Sodium proline symporter EPY81_RS13030 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EPY81_RS13040 ENOG4108ZX5 transcriptional regulator EPY81_RS13050 ENOG4105BZ1 (ABC) transporter EPY81_RS13055 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme EPY81_RS13060 ENOG4105XPP Protein of unknown function (DUF1275) EPY81_RS13070 ENOG41080HT Transcriptional regulator, arsr family EPY81_RS13080 ENOG4105EZE Cupin 4 family protein EPY81_RS13085 ENOG4108UHJ MAF-like protein EPY81_RS13105 ENOG4105D2N Aldolase EPY81_RS13110 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EPY81_RS13115 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EPY81_RS13120 ENOG4105EHM Aminoglycoside phosphotransferase EPY81_RS13125 ENOG4108S0S Nucleotidyl transferase EPY81_RS13135 ENOG4107QJE Chromosome Partitioning Protein EPY81_RS13140 ENOG4105FA0 parb-like partition protein EPY81_RS13155 ENOG4105BZ1 (ABC) transporter EPY81_RS13160 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EPY81_RS13170 ENOG4107QRG dna polymerase iii EPY81_RS13180 ENOG4105F8V Hydrolase, tatD family EPY81_RS13205 ENOG4108RTD type II secretion system protein K EPY81_RS13225 ENOG4108Z6B deaminase EPY81_RS13240 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EPY81_RS13245 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EPY81_RS13260 ENOG4105DWU Membrane EPY81_RS13265 ENOG4107RN6 Monooxygenase EPY81_RS13275 ENOG4105D6Z AFG1 family ATPase EPY81_RS13280 ENOG4107QP3 malate synthase g EPY81_RS13290 ENOG4105SG9 biopolymer transport protein, ExbD EPY81_RS13325 ENOG4107QSI ABC, transporter EPY81_RS13330 ENOG4105DGW oligopeptidase A EPY81_RS13360 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EPY81_RS13375 ENOG4105K4T epimerase EPY81_RS13380 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) EPY81_RS13400 ENOG4108JA2 transcriptioN-repair coupling factor EPY81_RS13410 ENOG4105F8J Adenylate Guanylate cyclase EPY81_RS13415 ENOG4108ZIT Ferredoxin, 2FE-2S EPY81_RS13430 ENOG4108Z4V iron-sulfur cluster assembly EPY81_RS13435 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EPY81_RS13445 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EPY81_RS13460 ENOG4105K70 DNA-binding protein EPY81_RS13465 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EPY81_RS13470 ENOG4105E7U AraC family transcriptional regulator EPY81_RS13475 ENOG4105EEF Alkane 1-monooxygenase EPY81_RS13480 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS13485 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS13500 ENOG4108Z66 YbaK ebsC protein EPY81_RS13520 ENOG4108YZT Adenosylcobinamide kinase EPY81_RS13525 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EPY81_RS13545 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EPY81_RS13550 ENOG4107TSN permease EPY81_RS13575 ENOG4105CNM Receptor EPY81_RS13580 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EPY81_RS13605 ENOG4105K59 histidine triad (HIT) protein EPY81_RS13625 ENOG4105C28 cystathionine EPY81_RS13640 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EPY81_RS13655 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EPY81_RS13700 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EPY81_RS13705 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EPY81_RS13730 ENOG4105BZU Histidine kinase EPY81_RS13745 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EPY81_RS13750 ENOG4107R0V Pyruvate dehydrogenase EPY81_RS13755 ENOG4105CPP Dehydrogenase, E1 component EPY81_RS13770 ENOG4105CHR reductase EPY81_RS13780 ENOG4105FFC UPF0187 protein EPY81_RS13790 ENOG4107QPB Beta-lactamase domain protein EPY81_RS13800 ENOG4108VCT Sulfite exporter TauE/SafE EPY81_RS13820 ENOG4105UEI Transcriptional Regulator AraC Family EPY81_RS13825 ENOG4105KVH Transcriptional regulator EPY81_RS13830 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EPY81_RS13840 ENOG4105CSH Transporter EPY81_RS13850 ENOG4108IJ0 Aspartate ammonia-lyase EPY81_RS13865 ENOG4107YNJ LysR family Transcriptional regulator EPY81_RS13875 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS13880 ENOG4105CRW Short chain fatty acid transporter EPY81_RS13895 ENOG4108M0I Transcriptional regulator EPY81_RS13935 ENOG4105CY2 Citrate transporter EPY81_RS13940 ENOG4105DTD Dehydrogenase EPY81_RS13945 ENOG4105CF7 AraC family transcriptional regulator EPY81_RS13950 ENOG4105D2S major facilitator superfamily EPY81_RS13965 ENOG4105CHR reductase EPY81_RS13990 ENOG4105F57 Anthranilate dioxygenase reductase EPY81_RS13995 ENOG4108YS2 small subunit EPY81_RS14000 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit EPY81_RS14005 ENOG4105F4R Transcriptional regulator mode EPY81_RS14010 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EPY81_RS14015 ENOG4105E0C molybdate abc transporter EPY81_RS14020 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EPY81_RS14025 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EPY81_RS14030 ENOG4105WQI isochorismatase EPY81_RS14040 ENOG4107T31 5'-nucleotidase EPY81_RS14050 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) EPY81_RS14055 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) EPY81_RS14065 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E EPY81_RS14070 ENOG4108IGT Dipeptidase EPY81_RS14085 ENOG4105BZS acriflavin resistance protein EPY81_RS14090 ENOG4105C1P efflux transporter, rnd family, mfp subunit EPY81_RS14095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EPY81_RS14100 ENOG4105E0F Histidine kinase EPY81_RS14110 ENOG4107RZC phospholipase d EPY81_RS14165 ENOG4105X0I Fimbrial EPY81_RS14240 ENOG4105VYA Uncharacterized conserved protein (DUF2132) EPY81_RS14250 ENOG4107IFA Lipase (EC 3.1.1.3) EPY81_RS14255 ENOG4108ZX5 transcriptional regulator EPY81_RS14260 ENOG4108821 RND type efflux pump EPY81_RS14300 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EPY81_RS14360 ENOG4105C75 arginyL-tRNA synthetase EPY81_RS14400 ENOG4105CEY Amp-dependent synthetase and ligase EPY81_RS14410 ENOG4105CSU acyl-Coa dehydrogenase EPY81_RS14420 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr EPY81_RS14425 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EPY81_RS14430 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EPY81_RS14435 ENOG4108PTX LysR family Transcriptional regulator EPY81_RS14440 ENOG4107Z3H Transcriptional regulator, TetR family EPY81_RS14480 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EPY81_RS14500 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EPY81_RS14510 ENOG4107XKF NMT1 THI5 Like Domain Protein EPY81_RS14520 ENOG41073TP transcriptional regulator EPY81_RS14525 ENOG41061H0 Monooxygenase EPY81_RS14535 ENOG4105C2W permease EPY81_RS14540 ENOG4105VT2 5-hydroxyisourate hydrolase EPY81_RS14545 ENOG4105CZJ Aldehyde dehydrogenase EPY81_RS14565 ENOG4107EJG GntR family transcriptional regulator EPY81_RS14575 ENOG4108KB2 LysR family Transcriptional regulator EPY81_RS14580 ENOG4105DTQ mandelate racemase muconate lactonizing EPY81_RS14585 ENOG4105NN7 muconolactone delta-isomerase EPY81_RS14595 ENOG4107QP7 CoA-transferase subunit A EPY81_RS14600 ENOG4107QNJ CoA-transferase subunit B EPY81_RS14605 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS14610 ENOG4105F2Z 3-oxoadipate enol-lactonase EPY81_RS14615 ENOG4105C26 Dehydrogenase EPY81_RS14625 ENOG4105F11 amine oxidase EPY81_RS14645 ENOG4105CHR reductase EPY81_RS14655 ENOG4105FUY alpha subunit EPY81_RS14675 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EPY81_RS14685 ENOG4105DNH Major Facilitator EPY81_RS14710 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS14715 ENOG4108PTX LysR family Transcriptional regulator EPY81_RS14720 ENOG4107HP6 Transcriptional regulator EPY81_RS14735 ENOG4105MD1 YeeE YedE family protein EPY81_RS14745 ENOG4105DZG Dehydrogenase EPY81_RS14750 ENOG4105TW1 Carbohydrate-selective porin OprB EPY81_RS14755 ENOG4106JPM 3-dehydroshikimate dehydratase EPY81_RS14760 ENOG4105FF2 Type I DHQase EPY81_RS14765 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha EPY81_RS14770 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta EPY81_RS14775 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EPY81_RS14780 ENOG4105D2S major facilitator superfamily EPY81_RS14785 ENOG4105F2Z 3-oxoadipate enol-lactonase EPY81_RS14790 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase EPY81_RS14795 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS14800 ENOG4107QNJ CoA-transferase subunit B EPY81_RS14805 ENOG4107QP7 CoA-transferase subunit A EPY81_RS14815 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EPY81_RS14820 ENOG4105CNM Receptor EPY81_RS14830 ENOG4107VMU Membrane EPY81_RS14835 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EPY81_RS14875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EPY81_RS14890 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EPY81_RS14900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EPY81_RS14905 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EPY81_RS14935 ENOG4105C7B Threonine dehydratase EPY81_RS14945 ENOG4105CZN Potassium uptake protein EPY81_RS14950 ENOG4105HDD phospholipase EPY81_RS14970 ENOG4105PV3 Inner membrane protein yqiJ EPY81_RS14980 ENOG4105C4M (Ubiquinol oxidase) subunit I EPY81_RS14985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EPY81_RS15015 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EPY81_RS15040 ENOG4105C2X Arabinose 5-phosphate isomerase EPY81_RS15045 ENOG4105C8Y Acetylornithine aminotransferase EPY81_RS15050 ENOG4105M2J Glutaredoxin EPY81_RS15060 ENOG4105CC0 LysR family Transcriptional regulator EPY81_RS15065 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EPY81_RS15070 ENOG4105CWM branched-chain amino acid transport system II carrier protein EPY81_RS15075 ENOG4108ZJF Glcg protein EPY81_RS15095 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EPY81_RS15100 ENOG4105DE4 1-phosphofructokinase EPY81_RS15105 ENOG4105DM4 PTS System EPY81_RS15120 ENOG4105BZU Histidine kinase EPY81_RS15130 ENOG4105D8V Glucose sorbosone dehydrogenase EPY81_RS15140 ENOG4105CHH sulfate transporter EPY81_RS15160 ENOG4105C85 amino acid EPY81_RS15170 ENOG4105F7P transcriptional regulator AsnC family EPY81_RS15185 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 EPY81_RS15190 ENOG4105VEJ Heat shock protein EPY81_RS15200 ENOG4105Y3E Modulates RecA activity (By similarity) EPY81_RS15215 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EPY81_RS15240 ENOG4105DZP Membrane-associated zinc metalloprotease EPY81_RS15250 ENOG4105KNE Phosphatidate cytidylyltransferase EPY81_RS15255 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EPY81_RS15280 ENOG4105CUX Signal transduction histidine kinase EPY81_RS15285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EPY81_RS15335 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EPY81_RS15355 ENOG4105CMR udp-glucose 4-epimerase EPY81_RS15380 ENOG4105T38 integral membrane protein EPY81_RS15385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EPY81_RS15395 ENOG4105CVM Molybdenum cofactor synthesis domain protein EPY81_RS15400 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EPY81_RS15435 ENOG4108IFG nitrite reductase, (NAD(P)H) EPY81_RS15440 ENOG4107QZF nitrite reductase NADPH large subunit EPY81_RS15465 ENOG4105CIF Ornithine Cyclodeaminase EPY81_RS15470 ENOG4105DJU Siderophore biosynthesis protein EPY81_RS15480 ENOG4105DUU IucA IucC family protein EPY81_RS15505 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EPY81_RS15510 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EPY81_RS15520 ENOG4105D8G Major Facilitator superfamily EPY81_RS15530 ENOG4108D1K outer membrane usher protein EPY81_RS15590 ENOG4108RWI nicotinamidase EPY81_RS15605 ENOG4105C0A alcohol dehydrogenase EPY81_RS15615 ENOG4105HSS phospholipase C EPY81_RS15620 ENOG4107QMP dna polymerase iii subunits gamma and tau EPY81_RS15655 ENOG4105CHR reductase EPY81_RS15660 ENOG4105CHU acetyl-coa acetyltransferase EPY81_RS15670 ENOG4105CC0 LysR family Transcriptional regulator EPY81_RS15675 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EPY81_RS15680 ENOG4108NIW Leucine export protein LeuE EPY81_RS15685 ENOG4105EW9 transcriptional regulator AsnC family EPY81_RS15690 ENOG4105DKK Benzoate EPY81_RS15715 ENOG41081QV Universal stress protein EPY81_RS15720 ENOG4105C5H ABC transporter EPY81_RS15725 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium EPY81_RS15780 ENOG4105KUS lysozyme EPY81_RS15815 ENOG41089BK Glutamine amido-transferase EPY81_RS15835 ENOG4108ESX Receptor EPY81_RS15840 ENOG4105GAV receptor EPY81_RS15855 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) EPY81_RS15880 ENOG4108D1K outer membrane usher protein EPY81_RS15895 ENOG4105CD8 aminopeptidase N EPY81_RS15920 ENOG4107QUV Domain protein EPY81_RS15925 ENOG4105C0A alcohol dehydrogenase EPY81_RS15935 ENOG4107RR1 TRANSCRIPTIONal EPY81_RS15945 ENOG4107R55 ethanolamine transporter EPY81_RS15950 ENOG4105CPD ethanolamine ammonia-lyase EPY81_RS15955 ENOG4107FQ9 ethanolamine ammonia-lyase EPY81_RS15960 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EPY81_RS15965 ENOG4105CX6 glutaminyL-tRNA synthetase EPY81_RS15975 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) EPY81_RS15985 ENOG4108RCM Nitroreductase EPY81_RS15990 ENOG4108TZV Membrane EPY81_RS15995 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EPY81_RS16005 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EPY81_RS16010 ENOG4105K8N protein family UPF0079, ATPase EPY81_RS16030 ENOG4105I08 Pseudouridine synthase EPY81_RS16045 ENOG4105DZ2 Transcriptional regulator EPY81_RS16145 ENOG4108QUU Morphogenesis Protein EPY81_RS16165 ENOG4105CF2 Mu-like prophage FluMu protein GP28 EPY81_RS16250 ENOG4105K70 DNA-binding protein EPY81_RS16285 ENOG4105F27 Major Facilitator EPY81_RS16290 ENOG4105EYW Ion transport protein EPY81_RS16300 ENOG4107QIJ Aconitate hydratase 2 EPY81_RS16320 ENOG4105CFU surface antigen EPY81_RS16325 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) EPY81_RS16340 ENOG4105CFQ glutamine synthetase EPY81_RS16345 ENOG4105EEX Two component transcriptional regulator (Winged helix family EPY81_RS16350 ENOG4105C08 Histidine kinase EPY81_RS16355 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EPY81_RS16360 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EPY81_RS16365 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EPY81_RS16375 ENOG4105KRF dihydroneopterin aldolase EPY81_RS16385 ENOG4105D06 uba thif-type nad fad binding protein EPY81_RS16390 ENOG4108MEJ flavin reductase domain protein EPY81_RS16395 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS16410 ENOG4105GVF (ABC) transporter EPY81_RS16415 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EPY81_RS16420 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EPY81_RS16435 ENOG4105CC0 LysR family Transcriptional regulator EPY81_RS16450 ENOG4105DEN Luciferase family EPY81_RS16460 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD EPY81_RS16465 ENOG4105CND Glycosyl transferase, family 2 EPY81_RS16470 ENOG4107BJW polysaccharide deacetylase EPY81_RS16495 ENOG4105E2S oxidase) subunit II EPY81_RS16500 ENOG4105BZ9 Cytochrome C oxidase, subunit I EPY81_RS16505 ENOG4105CCU oxidase (Subunit III) EPY81_RS16510 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EPY81_RS16535 ENOG4105CDU Replicative dna helicase EPY81_RS16540 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EPY81_RS16590 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) EPY81_RS16600 ENOG4105C12 Phosphoribosylglycinamide synthetase EPY81_RS16605 ENOG4105D01 (LipO)protein EPY81_RS16610 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EPY81_RS16615 ENOG4108UMI ABC transporter, permease EPY81_RS16620 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EPY81_RS16630 ENOG4105CK2 sodium dicarboxylate symporter EPY81_RS16675 ENOG4105ETX regulatoR EPY81_RS16680 ENOG4105DHQ Histidine kinase EPY81_RS16685 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EPY81_RS16695 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EPY81_RS16735 ENOG4105VT2 5-hydroxyisourate hydrolase EPY81_RS16745 ENOG4105DY2 Paraquat-inducible protein b EPY81_RS16750 ENOG4105F1S paraquat-inducible protein a EPY81_RS16765 ENOG4105CEB Aspartate aminotransferase EPY81_RS16770 ENOG4105R8C Transcriptional regulator EPY81_RS16785 ENOG4105CKD glutathione-regulated potassium-efflux system protein EPY81_RS16790 ENOG4105D6U Sodium Glutamate Symporter EPY81_RS16810 ENOG4105VEQ Cold shock protein EPY81_RS16860 ENOG4105VCC 30S ribosomal protein S21 EPY81_RS16865 ENOG4105KTH gatB Yqey EPY81_RS16870 ENOG4105ERG peptidase m48, ste24p EPY81_RS16875 ENOG4105C5I Dehydrogenase EPY81_RS16890 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EPY81_RS16925 ENOG41069NU Nitroreductase EPY81_RS16935 ENOG4105C1J atp-dependent rna helicase EPY81_RS16940 ENOG4105VEQ Cold shock protein EPY81_RS16950 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EPY81_RS16955 ENOG4105M08 Membrane EPY81_RS16985 ENOG4105CYB regulatoR EPY81_RS16990 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EPY81_RS16995 ENOG4105E0Y RtcB Protein EPY81_RS17015 ENOG4105CIN aminoacyl-histidine dipeptidase EPY81_RS17025 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EPY81_RS17030 ENOG4105CQC Prephenate dehydratase EPY81_RS17040 ENOG4105C1G acyl-Coa dehydrogenase EPY81_RS17045 ENOG4105CK2 sodium dicarboxylate symporter EPY81_RS17055 ENOG4105VUT cytoplasmic protein EPY81_RS17060 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EPY81_RS17065 ENOG4105BZ4 penicillin-binding protein EPY81_RS17075 ENOG4105M6F mutator MutT protein EPY81_RS17085 ENOG4105DHQ Histidine kinase EPY81_RS17090 ENOG4105XJC Two component transcriptional regulator (Winged helix family EPY81_RS17100 ENOG4107QHF type ii secretion system protein e EPY81_RS17110 ENOG4108R96 Methyltransferase, YaeB family EPY81_RS17115 ENOG4105DP0 ferredoxin-NADP reductase EPY81_RS17120 ENOG4105JAB phenazine biosynthesis protein, phzf family EPY81_RS17125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EPY81_RS17130 ENOG4105CFP Peptidase U32 EPY81_RS17135 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EPY81_RS17145 ENOG4108JEH abc transporter atp-binding protein EPY81_RS17150 ENOG4106YG3 ABC transporter EPY81_RS17155 ENOG4105DSP amino acid AbC transporter EPY81_RS17160 ENOG4105E89 ABC transporter EPY81_RS17170 ENOG4105ENT Efflux transporter rnd family, mfp subunit EPY81_RS17180 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EPY81_RS17215 ENOG4105DA5 (ABC) transporter EPY81_RS17220 ENOG4105E3A (ABC) transporter EPY81_RS17235 ENOG4105CNI cell division protein FtsW EPY81_RS17240 ENOG4105CVE Lytic murein transglycosylase EPY81_RS17280 ENOG4105CE9 30S ribosomal protein S2 EPY81_RS17285 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EPY81_RS17295 ENOG4107RNU major facilitator superfamily MFS_1 EPY81_RS17305 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) EPY81_RS17310 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EPY81_RS17315 ENOG4107QPN acyl-Coa dehydrogenase EPY81_RS17330 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EPY81_RS17335 ENOG4105SYT Methylenetetrahydrofolate reductase EPY81_RS17340 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EPY81_RS17345 ENOG4105BZU Histidine kinase EPY81_RS17350 ENOG4105C6K Malic enzyme EPY81_RS17360 ENOG4105C0H protease EPY81_RS17365 ENOG4107QNR UPF0135 protein EPY81_RS17370 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EPY81_RS17405 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EPY81_RS17415 ENOG4105C5F glutamine synthetase EPY81_RS17420 ENOG4105DUX Transporter EPY81_RS17430 ENOG4105DFP Integrase EPY81_RS17475 ENOG4105NVB glycoside hydrolase, family 19 EPY81_RS17515 ENOG4105YB8 TM2 domain containing protein EPY81_RS17575 ENOG41090AG Bacteriophage protein EPY81_RS17595 ENOG4107ZQ5 Phage-associated protein, HI1409 family EPY81_RS17685 ENOG4105W7J DNA binding EPY81_RS17690 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EPY81_RS17740 ENOG4105DDQ anthranilate synthase EPY81_RS17745 ENOG4105CD8 aminopeptidase N EPY81_RS17750 ENOG4105D05 Receptor EPY81_RS17765 ENOG4108DG9 Smr protein MutS2 EPY81_RS17775 ENOG4105C7W Xanthine dehydrogenase EPY81_RS17785 ENOG4105EUJ GTP cyclohydrolase i EPY81_RS17805 ENOG4105NX3 Membrane EPY81_RS17820 ENOG4105E4F Isochorismate synthase EPY81_RS17840 ENOG4105BZ1 (ABC) transporter EPY81_RS17855 ENOG4105WQI isochorismatase EPY81_RS17860 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EPY81_RS17865 ENOG4105C0W non-ribosomal peptide synthetase EPY81_RS17885 ENOG4108IPW abc transporter atp-binding protein EPY81_RS17900 ENOG4105CEY Amp-dependent synthetase and ligase EPY81_RS17915 ENOG4105C2I pirin domain protein EPY81_RS17970 ENOG4108ZXE EPY81_RS18000 ENOG4105DFP Integrase EPY81_RS18010 ENOG4105VCD cytoplasmic protein EPY81_RS18015 ENOG4105D22 carbon starvation protein EPY81_RS18020 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EPY81_RS18025 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EPY81_RS18045 ENOG4105DHU Bile acid EPY81_RS18055 ENOG4105EYM Major Facilitator superfamily EPY81_RS18060 ENOG4105DAN ATP-dependent protease EPY81_RS18065 ENOG4105EJC lysr family transcriptional regulator EPY81_RS18070 ENOG4108K5P (LipO)protein EPY81_RS18090 ENOG4105DZ1 carboxypeptidase EPY81_RS18095 ENOG4108Z0R Transferase EPY81_RS18120 ENOG4107QTF adenylosuccinate lyase EPY81_RS18135 ENOG4105ERU peptidase EPY81_RS18140 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EPY81_RS18150 ENOG4105C8U phosphate abc transporter EPY81_RS18155 ENOG4105CVA phosphate EPY81_RS18160 ENOG4105C85 amino acid EPY81_RS18165 ENOG4107RA9 decarboxylase EPY81_RS18170 ENOG4105F7P transcriptional regulator AsnC family EPY81_RS18180 ENOG4105DY8 decarboxylase EPY81_RS18185 ENOG4108JPW Aminotransferase EPY81_RS18200 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EPY81_RS18215 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EPY81_RS18220 ENOG4105D3G Pseudouridine synthase EPY81_RS18235 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EPY81_RS18265 ENOG4105JAB phenazine biosynthesis protein, phzf family EPY81_RS18270 ENOG4108ETY sodium dicarboxylate symporter EPY81_RS18275 ENOG4105EGI Transcriptional regulator EPY81_RS18280 ENOG4105CBP Major Facilitator EPY81_RS18295 ENOG4108R99 pseudouridine synthase EPY81_RS18300 ENOG4105E9K Isocitrate dehydrogenase EPY81_RS18310 ENOG4105DZ1 carboxypeptidase EPY81_RS18315 ENOG4105CEP NADH dehydrogenase EPY81_RS18320 ENOG4108YZY peptidylprolyl cis-trans isomerase EPY81_RS18325 ENOG4105CVP deoxyribo-dipyrimidine photolyase EPY81_RS18340 ENOG4107R8N Glycosyl transferase, family 2 EPY81_RS18355 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EPY81_RS18370 ENOG4105EA8 2-Nitropropane dioxygenase EPY81_RS18375 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EPY81_RS18380 ENOG4107QS8 (LipO)protein EPY81_RS18415 ENOG4105DTR rard protein EPY81_RS18425 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EPY81_RS18435 ENOG4105BZU Histidine kinase EPY81_RS18475 ENOG4105EMU Dehydrogenase EPY81_RS18480 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase EPY81_RS18485 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EPY81_RS18490 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) EPY81_RS18500 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EPY81_RS18505 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EPY81_RS18515 ENOG4105C3F Signal peptidase i EPY81_RS18520 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EPY81_RS18525 ENOG41068WN EPY81_RS18535 ENOG4105C0H protease EPY81_RS18540 ENOG4108IYU L-aspartate oxidase EPY81_RS18555 ENOG4105HHA aminodeoxychorismate lyase EPY81_RS18560 ENOG4105YAZ 4-amino-4-deoxychorismate lyase EPY81_RS18565 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EPY81_RS18575 ENOG4108I5D sulfate abc transporter EPY81_RS18585 ENOG4108IJ6 ABC transporter EPY81_RS18590 ENOG4107R11 Transcriptional regulator EPY81_RS18605 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EPY81_RS18610 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EPY81_RS18625 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EPY81_RS18645 ENOG4108UKI Enoyl-CoA hydratase EPY81_RS18650 ENOG4105EGD dinuclear metal center protein, YbgI family EPY81_RS18655 ENOG4105C2C drug resistance transporter, Bcr CflA EPY81_RS18660 ENOG4108ETH Formylglycinamide ribotide synthetase EPY81_RS18680 ENOG4105CH2 amidohydrolase EPY81_RS18685 ENOG4107YD3 Thioesterase EPY81_RS18690 ENOG4105E02 MotA TolQ exbB proton channel EPY81_RS18695 ENOG4105M8F Biopolymer transport protein exbD tolR EPY81_RS18705 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) EPY81_RS18710 ENOG4105KCK Peptidoglycan-associated lipoprotein EPY81_RS18760 ENOG4105C02 permease EPY81_RS18770 ENOG4108V3E phosphoribosylglycinamide formyltransferase EPY81_RS18775 ENOG4107R6F Alpha Beta Hydrolase Fold protein EPY81_RS18780 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EPY81_RS18790 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EPY81_RS18795 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EPY81_RS18800 ENOG4105D60 lipoprotein releasing system transmembrane protein EPY81_RS18830 ENOG4107KET secretion protein, HlyD family EPY81_RS18845 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPY81_RS18850 ENOG4105C10 Electron transfer flavoprotein EPY81_RS18855 ENOG4105BZJ Electron transfer flavoprotein EPY81_RS18860 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EPY81_RS18865 ENOG4105N14 lysine exporter protein LysE YggA EPY81_RS18875 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EPY81_RS18885 ENOG4105C85 amino acid EPY81_RS18890 ENOG4105BZG amino acid carrier protein EPY81_RS18895 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EPY81_RS18905 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EPY81_RS18920 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EPY81_RS18925 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EPY81_RS18930 ENOG4105BZW Glycerate kinase EPY81_RS18950 ENOG4105BZS acriflavin resistance protein EPY81_RS18955 ENOG4105C1P efflux transporter, rnd family, mfp subunit EPY81_RS18980 ENOG4105D01 (LipO)protein EPY81_RS18990 ENOG4108RRZ Transcription elongation factor GreB EPY81_RS18995 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EPY81_RS19020 ENOG4105E4C Lytic transglycosylase catalytic EPY81_RS19035 ENOG4105BZS acriflavin resistance protein EPY81_RS19040 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EPY81_RS19050 ENOG41080IJ Diacylglycerol kinase EPY81_RS19070 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EPY81_RS19085 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EPY81_RS19090 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EPY81_RS19095 ENOG4105CSH Transporter EPY81_RS19105 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EPY81_RS19145 ENOG4105EEI dihydropteroate synthase EPY81_RS19150 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EPY81_RS19160 ENOG4105HBR Rna-binding protein EPY81_RS19180 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EPY81_RS19185 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EPY81_RS19195 ENOG4108Q5F Tetr family transcriptional regulator EPY81_RS19200 ENOG4108UQ8 endoribonuclease L-psp EPY81_RS19210 ENOG41080TK Universal stress protein EPY81_RS19230 ENOG4105PNM synthesis protein