locus-tag	class	description
EPY81_RS00015	COG2321	neutral zinc metallopeptidase
EPY81_RS00020	COG2354	Protein conserved in bacteria
EPY81_RS00040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPY81_RS00065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPY81_RS00070	COG1053	succinate dehydrogenase
EPY81_RS00075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPY81_RS00080	COG2009	succinate dehydrogenase
EPY81_RS00120	COG2921	Belongs to the UPF0250 family
EPY81_RS00125	COG0321	lipoyl(octanoyl) transferase activity
EPY81_RS00140	COG0531	amino acid
EPY81_RS00175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPY81_RS00180	COG1648	precorrin-2 dehydrogenase activity
EPY81_RS00180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPY81_RS00195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPY81_RS00220	COG0671	phosphoesterase, PA-phosphatase related
EPY81_RS00225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_RS00235	COG1538	Outer membrane efflux protein
EPY81_RS00240	COG0393	Putative heavy-metal-binding
EPY81_RS00245	COG0393	Putative heavy-metal-binding
EPY81_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS00265	COG0525	valine-tRNA ligase activity
EPY81_RS00285	COG0583	DNA-binding transcription factor activity
EPY81_RS00290	COG0004	ammonium transporteR
EPY81_RS00305	COG0642	Histidine kinase
EPY81_RS00310	COG0745	RESPONSE REGULATOR receiver
EPY81_RS00315	COG2194	sulfuric ester hydrolase activity
EPY81_RS00340	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPY81_RS00355	COG2315	Protein conserved in bacteria
EPY81_RS00360	COG0142	geranyltranstransferase activity
EPY81_RS00370	COG1113	amino acid transport
EPY81_RS00380	COG3046	protein related to deoxyribodipyrimidine photolyase
EPY81_RS00400	COG0582	viral genome integration into host DNA
EPY81_RS00430	COG0305	Participates in initiation and elongation during chromosome replication
EPY81_RS00510	COG2207	Transcriptional regulator
EPY81_RS00535	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_RS00555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPY81_RS00565	COG1530	ribonuclease E activity
EPY81_RS00570	COG0424	maF-like protein
EPY81_RS00575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPY81_RS00580	COG1792	Involved in formation and maintenance of cell shape
EPY81_RS00585	COG1077	Cell shape determining protein MreB Mrl
EPY81_RS00590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPY81_RS00600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPY81_RS00625	COG3590	peptidase
EPY81_RS00630	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EPY81_RS00635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPY81_RS00640	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPY81_RS00645	COG1115	amino acid carrier protein
EPY81_RS00665	COG2814	Major facilitator Superfamily
EPY81_RS00670	COG1289	transmembrane transporter activity
EPY81_RS00680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPY81_RS00720	COG1376	ErfK ybiS ycfS ynhG family protein
EPY81_RS00725	COG2832	Protein of unknown function (DUF454)
EPY81_RS00735	COG5510	response to toxic substance
EPY81_RS00755	COG0840	transmembrane signaling receptor activity
EPY81_RS00795	COG3422	double-strand break repair
EPY81_RS00800	COG2824	Alkylphosphonate utilization operon protein PhnA
EPY81_RS00810	COG0596	Alpha beta hydrolase
EPY81_RS00820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_RS00825	COG1335	isochorismatase
EPY81_RS00830	COG0251	oxidation-reduction process
EPY81_RS00835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_RS00840	COG2233	PERMEase
EPY81_RS00860	COG0354	folic acid binding
EPY81_RS00865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPY81_RS00875	COG0679	Auxin Efflux Carrier
EPY81_RS00880	COG1902	pentaerythritol trinitrate reductase activity
EPY81_RS00885	COG4772	TonB-dependent receptor
EPY81_RS00890	COG2094	Belongs to the DNA glycosylase MPG family
EPY81_RS00920	COG2233	PERMEase
EPY81_RS00930	COG0833	amino acid
EPY81_RS00935	COG1690	Belongs to the RtcB family
EPY81_RS00940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPY81_RS00940	COG2885	chlorophyll binding
EPY81_RS00950	COG0183	Belongs to the thiolase family
EPY81_RS00970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_RS00990	COG2207	Transcriptional regulator
EPY81_RS00995	COG0183	Belongs to the thiolase family
EPY81_RS01015	COG2153	protein acetylation
EPY81_RS01025	COG1272	protein, Hemolysin III
EPY81_RS01030	COG0477	Major facilitator Superfamily
EPY81_RS01045	COG0450	alkyl hydroperoxide reductase
EPY81_RS01065	COG0285	dihydrofolate synthase activity
EPY81_RS01100	COG0133	tryptophan synthase activity
EPY81_RS01110	COG4206	TonB-dependent receptor
EPY81_RS01115	COG2096	Adenosyltransferase
EPY81_RS01135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPY81_RS01145	COG0745	RESPONSE REGULATOR receiver
EPY81_RS01150	COG2205	protein histidine kinase activity
EPY81_RS01160	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS01165	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS01170	COG0583	DNA-binding transcription factor activity
EPY81_RS01175	COG0625	glutathione transferase activity
EPY81_RS01225	COG1216	Glycosyl transferase, family 2
EPY81_RS01240	COG0726	polysaccharide deacetylase
EPY81_RS01255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EPY81_RS01260	COG2198	Histidine kinase
EPY81_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_RS01260	COG0784	Response regulator, receiver
EPY81_RS01260	COG2205	protein histidine kinase activity
EPY81_RS01295	COG1862	Preprotein translocase
EPY81_RS01305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPY81_RS01310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPY81_RS01320	COG3781	membrane
EPY81_RS01335	COG2350	Protein conserved in bacteria
EPY81_RS01370	COG1607	acyl-coa hydrolase
EPY81_RS01385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPY81_RS01385	COG3453	Protein conserved in bacteria
EPY81_RS01440	COG2199	diguanylate cyclase activity
EPY81_RS01445	COG2885	chlorophyll binding
EPY81_RS01445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPY81_RS01450	COG1408	metallophosphoesterase
EPY81_RS01455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPY81_RS01465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPY81_RS01485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPY81_RS01490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPY81_RS01495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPY81_RS01500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPY81_RS01505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPY81_RS01510	COG0625	glutathione transferase activity
EPY81_RS01515	COG2969	positive regulation of protein catabolic process
EPY81_RS01555	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS01560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPY81_RS01575	COG1309	transcriptional regulator
EPY81_RS01580	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS01625	COG1183	phosphatidylcholine synthase activity
EPY81_RS01630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPY81_RS01660	COG0739	heme binding
EPY81_RS01660	COG1196	nuclear chromosome segregation
EPY81_RS01660	COG0741	lytic transglycosylase activity
EPY81_RS01670	COG1702	phosphate starvation-inducible protein PhoH
EPY81_RS01705	COG1295	ribonuclease BN
EPY81_RS01710	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPY81_RS01760	COG0557	exoribonuclease II activity
EPY81_RS01765	COG0339	signal peptide processing
EPY81_RS01770	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EPY81_RS01800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPY81_RS01805	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS01830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPY81_RS01840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPY81_RS01940	COG0088	Forms part of the polypeptide exit tunnel
EPY81_RS01945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPY81_RS01960	COG0626	cystathionine gamma-synthase activity
EPY81_RS01965	COG0433	COG0433 Predicted ATPase
EPY81_RS01975	COG1017	nitric oxide dioxygenase activity
EPY81_RS01975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_RS01980	COG1959	2 iron, 2 sulfur cluster binding
EPY81_RS01995	COG1301	dicarboxylic acid transport
EPY81_RS02000	COG1946	Acyl-CoA thioesterase
EPY81_RS02005	COG2937	Belongs to the GPAT DAPAT family
EPY81_RS02020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPY81_RS02025	COG1040	competence protein
EPY81_RS02030	COG0494	nUDIX hydrolase
EPY81_RS02040	COG0598	Magnesium transport protein CorA
EPY81_RS02050	COG2854	intermembrane phospholipid transfer
EPY81_RS02060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPY81_RS02065	COG1127	ABC transporter
EPY81_RS02075	COG0513	Belongs to the DEAD box helicase family
EPY81_RS02095	COG0408	coproporphyrinogen oxidase activity
EPY81_RS02110	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS02120	COG1983	PspC domain protein
EPY81_RS02125	COG4109	DRTGG domain
EPY81_RS02150	COG0752	glycyl-tRNA synthetase alpha subunit
EPY81_RS02175	COG5002	protein histidine kinase activity
EPY81_RS02190	COG0583	DNA-binding transcription factor activity
EPY81_RS02230	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS02240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPY81_RS02245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPY81_RS02250	COG0833	amino acid
EPY81_RS02280	COG1192	Involved in chromosome partitioning
EPY81_RS02285	COG0628	permease
EPY81_RS02295	COG1289	transmembrane transporter activity
EPY81_RS02310	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_RS02315	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPY81_RS02325	COG0277	FAD linked oxidase domain protein
EPY81_RS02330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPY81_RS02335	COG5006	permease, DMT superfamily
EPY81_RS02340	COG5006	permease, DMT superfamily
EPY81_RS02355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPY81_RS02360	COG5380	lipid catabolic process
EPY81_RS02370	COG0335	large ribosomal subunit rRNA binding
EPY81_RS02380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPY81_RS02430	COG0194	GDP metabolic process
EPY81_RS02445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPY81_RS02470	COG3307	-O-antigen
EPY81_RS02480	COG4969	Belongs to the N-Me-Phe pilin family
EPY81_RS02490	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EPY81_RS02495	COG1704	LemA family
EPY81_RS02505	COG0493	'glutamate synthase
EPY81_RS02510	COG0069	glutamate synthase activity
EPY81_RS02510	COG0070	glutamate synthase
EPY81_RS02510	COG0067	glutamate synthase
EPY81_RS02560	COG2226	methyltransferase
EPY81_RS02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPY81_RS02580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPY81_RS02625	COG0833	amino acid
EPY81_RS02645	COG0582	viral genome integration into host DNA
EPY81_RS02805	COG0488	(ABC) transporter
EPY81_RS02815	COG4221	oxidoreductase activity
EPY81_RS02820	COG0659	secondary active sulfate transmembrane transporter activity
EPY81_RS02830	COG0745	RESPONSE REGULATOR receiver
EPY81_RS02835	COG2205	protein histidine kinase activity
EPY81_RS02845	COG0427	acetyl-CoA hydrolase
EPY81_RS02875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPY81_RS02900	COG0697	spore germination
EPY81_RS02915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPY81_RS02975	COG2207	Transcriptional regulator
EPY81_RS02980	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EPY81_RS02990	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_RS02995	COG1733	regulation of RNA biosynthetic process
EPY81_RS03040	COG0667	Aldo Keto reductase
EPY81_RS03060	COG0583	DNA-binding transcription factor activity
EPY81_RS03065	COG2814	Major facilitator Superfamily
EPY81_RS03155	COG1335	isochorismatase
EPY81_RS03165	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS03170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPY81_RS03180	COG1113	amino acid transport
EPY81_RS03190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EPY81_RS03205	COG2814	Major facilitator Superfamily
EPY81_RS03215	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPY81_RS03215	COG0352	thiamine-phosphate diphosphorylase activity
EPY81_RS03215	COG0351	phosphomethylpyrimidine kinase
EPY81_RS03220	COG0789	Transcriptional regulator
EPY81_RS03225	COG0300	oxidoreductase activity
EPY81_RS03245	COG1309	transcriptional regulator
EPY81_RS03260	COG3706	GGDEF domain
EPY81_RS03270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPY81_RS03280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPY81_RS03285	COG3162	membrane
EPY81_RS03290	COG0784	Response regulator, receiver
EPY81_RS03290	COG2198	Histidine kinase
EPY81_RS03290	COG2205	protein histidine kinase activity
EPY81_RS03310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_RS03315	COG1522	sequence-specific DNA binding
EPY81_RS03320	COG1335	isochorismatase
EPY81_RS03325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPY81_RS03335	COG0668	transmembrane transport
EPY81_RS03340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPY81_RS03345	COG1519	Transferase
EPY81_RS03350	COG1902	pentaerythritol trinitrate reductase activity
EPY81_RS03370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPY81_RS03390	COG0426	domain, Protein
EPY81_RS03390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_RS03395	COG4774	siderophore transport
EPY81_RS03400	COG2119	membrane
EPY81_RS03410	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPY81_RS03420	COG4942	peptidase
EPY81_RS03435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPY81_RS03445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPY81_RS03465	COG0189	ligase activity
EPY81_RS03485	COG0708	Exodeoxyribonuclease III
EPY81_RS03490	COG1393	Belongs to the ArsC family
EPY81_RS03505	COG3706	GGDEF domain
EPY81_RS03540	COG2351	hydroxyisourate hydrolase activity
EPY81_RS03545	COG2233	PERMEase
EPY81_RS03555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_RS03565	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EPY81_RS03575	COG3150	esterase
EPY81_RS03610	COG3501	Rhs element vgr protein
EPY81_RS03620	COG2918	glutathione biosynthetic process
EPY81_RS03635	COG2733	membrane
EPY81_RS03640	COG0436	Aminotransferase
EPY81_RS03645	COG0534	Mate efflux family protein
EPY81_RS03750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPY81_RS03755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPY81_RS03765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPY81_RS03800	COG0010	Belongs to the arginase family
EPY81_RS03830	COG2188	Transcriptional regulator
EPY81_RS03840	COG0523	cobalamin synthesis protein
EPY81_RS03850	COG1113	amino acid transport
EPY81_RS03860	COG0625	glutathione transferase activity
EPY81_RS03865	COG0346	lactoylglutathione lyase activity
EPY81_RS03880	COG1683	Conserved Protein
EPY81_RS03885	COG0534	Mate efflux family protein
EPY81_RS03890	COG0385	Bile acid
EPY81_RS03895	COG1335	isochorismatase
EPY81_RS03900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPY81_RS03920	COG2116	formate transmembrane transporter activity
EPY81_RS03925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPY81_RS03930	COG2133	pyrroloquinoline quinone binding
EPY81_RS03935	COG2983	Belongs to the UPF0260 family
EPY81_RS03940	COG5487	UPF0391 membrane protein
EPY81_RS03955	COG1194	a g-specific adenine glycosylase
EPY81_RS03970	COG2818	Glycosylase
EPY81_RS03975	COG1064	alcohol dehydrogenase
EPY81_RS03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_RS03995	COG0583	DNA-binding transcription factor activity
EPY81_RS04000	COG0656	L-ascorbic acid biosynthetic process
EPY81_RS04005	COG2814	Major facilitator Superfamily
EPY81_RS04040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_RS04055	COG2233	PERMEase
EPY81_RS04095	COG0733	neurotransmitter:sodium symporter activity
EPY81_RS04105	COG0625	glutathione transferase activity
EPY81_RS04135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPY81_RS04140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPY81_RS04170	COG0488	(ABC) transporter
EPY81_RS04185	COG0187	DNA topoisomerase II activity
EPY81_RS04195	COG0592	DNA-directed DNA polymerase activity
EPY81_RS04205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPY81_RS04220	COG0706	membrane insertase activity
EPY81_RS04235	COG1230	cation diffusion facilitator family transporter
EPY81_RS04240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPY81_RS04255	COG0402	S-adenosylhomocysteine deaminase activity
EPY81_RS04265	COG0754	glutathionylspermidine amidase activity
EPY81_RS04275	COG0861	Integral membrane protein TerC family
EPY81_RS04280	COG0671	phosphoesterase, PA-phosphatase related
EPY81_RS04290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPY81_RS04305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPY81_RS04310	COG2951	lytic endotransglycosylase activity
EPY81_RS04365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPY81_RS04405	COG1047	Peptidyl-prolyl cis-trans
EPY81_RS04415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPY81_RS04420	COG0196	riboflavin kinase activity
EPY81_RS04430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPY81_RS04435	COG1309	transcriptional regulator
EPY81_RS04440	COG1116	anion transmembrane transporter activity
EPY81_RS04445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_RS04450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_RS04455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_RS04460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_RS04465	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPY81_RS04465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPY81_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS04485	COG0546	phosphoglycolate phosphatase activity
EPY81_RS04540	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPY81_RS04545	COG0728	peptidoglycan biosynthetic process
EPY81_RS04575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EPY81_RS04595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EPY81_RS04605	COG1091	dTDP-4-dehydrorhamnose reductase activity
EPY81_RS04620	COG1215	transferase activity, transferring glycosyl groups
EPY81_RS04640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPY81_RS04645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EPY81_RS04660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPY81_RS04670	COG2186	Transcriptional regulator
EPY81_RS04680	COG0277	FAD linked oxidase domain protein
EPY81_RS04685	COG1448	Aminotransferase
EPY81_RS04695	COG1802	Transcriptional regulator
EPY81_RS04710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EPY81_RS04730	COG1051	belongs to the nudix hydrolase family
EPY81_RS04790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPY81_RS04815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPY81_RS04835	COG0564	pseudouridine synthase activity
EPY81_RS04860	COG1522	sequence-specific DNA binding
EPY81_RS04875	COG0251	oxidation-reduction process
EPY81_RS04880	COG1113	amino acid transport
EPY81_RS04885	COG1113	amino acid transport
EPY81_RS04905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPY81_RS04910	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS04915	COG1024	Enoyl-CoA hydratase
EPY81_RS04920	COG1024	Enoyl-CoA hydratase
EPY81_RS04925	COG0477	Major facilitator Superfamily
EPY81_RS04930	COG0697	spore germination
EPY81_RS04935	COG1113	amino acid transport
EPY81_RS04940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPY81_RS04950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_RS04955	COG3916	Acyl-homoserine-lactone synthase
EPY81_RS04965	COG2197	response regulator
EPY81_RS04970	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_RS04975	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS04980	COG0300	oxidoreductase activity
EPY81_RS04980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPY81_RS04980	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS04980	COG3321	synthase
EPY81_RS05020	COG0271	Belongs to the BolA IbaG family
EPY81_RS05030	COG1192	Involved in chromosome partitioning
EPY81_RS05045	COG0586	Pfam SNARE associated Golgi protein
EPY81_RS05050	COG2259	Doxx family
EPY81_RS05055	COG4399	Belongs to the UPF0754 family
EPY81_RS05060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPY81_RS05060	COG0519	Catalyzes the synthesis of GMP from XMP
EPY81_RS05100	COG0281	malic enzyme
EPY81_RS05105	COG2837	iron assimilation
EPY81_RS05110	COG1280	lysine exporter protein (LysE YggA)
EPY81_RS05115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPY81_RS05120	COG1121	(ABC) transporter
EPY81_RS05160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPY81_RS05170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPY81_RS05185	COG0386	Belongs to the glutathione peroxidase family
EPY81_RS05200	COG1309	transcriptional regulator
EPY81_RS05205	COG0697	spore germination
EPY81_RS05215	COG0758	DNA mediated transformation
EPY81_RS05250	COG1309	transcriptional regulator
EPY81_RS05280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPY81_RS05295	COG0655	NAD(P)H dehydrogenase (quinone) activity
EPY81_RS05335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPY81_RS05345	COG2814	Major facilitator Superfamily
EPY81_RS05355	COG1253	flavin adenine dinucleotide binding
EPY81_RS05365	COG2860	membrane
EPY81_RS05370	COG0477	Major facilitator Superfamily
EPY81_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_RS05395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPY81_RS05415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPY81_RS05420	COG0235	Class ii aldolase
EPY81_RS05425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_RS05430	COG0431	NADPH-dependent FMN reductase
EPY81_RS05435	COG0606	chelatase, subunit chli
EPY81_RS05445	COG0347	Belongs to the P(II) protein family
EPY81_RS05450	COG0004	ammonium transporteR
EPY81_RS05460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPY81_RS05460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPY81_RS05500	COG0795	lipopolysaccharide-transporting ATPase activity
EPY81_RS05505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPY81_RS05510	COG0793	Belongs to the peptidase S41A family
EPY81_RS05525	COG2197	response regulator
EPY81_RS05535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPY81_RS05545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPY81_RS05550	COG4974	Belongs to the 'phage' integrase family
EPY81_RS05575	COG0772	Belongs to the SEDS family
EPY81_RS05580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPY81_RS05585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPY81_RS05590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EPY81_RS05595	COG0494	nUDIX hydrolase
EPY81_RS05615	COG0697	spore germination
EPY81_RS05625	COG1538	Outer membrane efflux protein
EPY81_RS05645	COG3275	phosphorelay sensor kinase activity
EPY81_RS05655	COG0181	hydroxymethylbilane synthase activity
EPY81_RS05700	COG1716	ATPase activity
EPY81_RS05705	COG0546	phosphoglycolate phosphatase activity
EPY81_RS05735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPY81_RS05805	COG2056	Na+-H+ antiporter family
EPY81_RS05820	COG0326	Molecular chaperone. Has ATPase activity
EPY81_RS05835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EPY81_RS05900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPY81_RS05905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPY81_RS05905	COG2169	Transcriptional regulator
EPY81_RS05940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPY81_RS05950	COG0497	DNA recombination
EPY81_RS05965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPY81_RS05975	COG0237	dephospho-CoA kinase activity
EPY81_RS06025	COG0195	Participates in both transcription termination and antitermination
EPY81_RS06035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPY81_RS06045	COG2212	antiporter activity
EPY81_RS06055	COG0651	ATP synthesis coupled electron transport
EPY81_RS06060	COG1006	Multisubunit Na H antiporter MnhC subunit
EPY81_RS06065	COG2111	Na H antiporter
EPY81_RS06065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPY81_RS06090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_RS06105	COG2226	methyltransferase
EPY81_RS06125	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EPY81_RS06130	COG1074	ATP-dependent DNA helicase activity
EPY81_RS06135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPY81_RS06150	COG1185	polyribonucleotide nucleotidyltransferase activity
EPY81_RS06155	COG0598	Magnesium transport protein CorA
EPY81_RS06160	COG0789	Transcriptional regulator
EPY81_RS06165	COG0484	heat shock protein binding
EPY81_RS06175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EPY81_RS06185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPY81_RS06205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPY81_RS06215	COG4535	Mg2 and Co2 transporter CorC
EPY81_RS06230	COG0644	oxidoreductase
EPY81_RS06230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EPY81_RS06240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPY81_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPY81_RS06260	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EPY81_RS06270	COG0493	'glutamate synthase
EPY81_RS06295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPY81_RS06310	COG0534	Mate efflux family protein
EPY81_RS06320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPY81_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS06330	COG0583	DNA-binding transcription factor activity
EPY81_RS06350	COG1530	ribonuclease E activity
EPY81_RS06360	COG0546	phosphoglycolate phosphatase activity
EPY81_RS06365	COG2378	regulation of single-species biofilm formation
EPY81_RS06370	COG0625	glutathione transferase activity
EPY81_RS06380	COG0583	DNA-binding transcription factor activity
EPY81_RS06420	COG0583	DNA-binding transcription factor activity
EPY81_RS06445	COG0473	3-isopropylmalate dehydrogenase activity
EPY81_RS06500	COG1301	dicarboxylic acid transport
EPY81_RS06510	COG1560	Kdo2-lipid A biosynthetic process
EPY81_RS06525	COG2900	Belongs to the SlyX family
EPY81_RS06535	COG1733	regulation of RNA biosynthetic process
EPY81_RS06560	COG0210	DNA helicase
EPY81_RS06565	COG0724	RNA recognition motif
EPY81_RS06585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPY81_RS06585	COG4651	solute:proton antiporter activity
EPY81_RS06590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPY81_RS06595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPY81_RS06610	COG0788	formyltetrahydrofolate deformylase activity
EPY81_RS06710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPY81_RS06710	COG2813	Specifically methylates the guanine in position
EPY81_RS06720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPY81_RS06730	COG4774	siderophore transport
EPY81_RS06740	COG0740	serine-type endopeptidase activity
EPY81_RS06760	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EPY81_RS06760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EPY81_RS06765	COG0857	belongs to the CobB CobQ family
EPY81_RS06765	COG0280	phosphate acetyltransferase
EPY81_RS06770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPY81_RS06785	COG0800	Aldolase
EPY81_RS06795	COG3265	gluconokinase activity
EPY81_RS06800	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS06810	COG2267	carboxylic ester hydrolase activity
EPY81_RS06825	COG0793	Belongs to the peptidase S41A family
EPY81_RS06860	COG1426	Protein conserved in bacteria
EPY81_RS06880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPY81_RS06900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPY81_RS06910	COG1162	GTPase activity
EPY81_RS06915	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPY81_RS06945	COG0577	efflux transmembrane transporter activity
EPY81_RS06945	COG1136	(ABC) transporter
EPY81_RS06950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_RS06970	COG0028	Belongs to the TPP enzyme family
EPY81_RS06975	COG0440	acetolactate synthase activity
EPY81_RS06980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPY81_RS07000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EPY81_RS07015	COG0084	hydrolase, TatD family'
EPY81_RS07025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPY81_RS07035	COG0583	DNA-binding transcription factor activity
EPY81_RS07050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPY81_RS07130	COG2217	Heavy metal translocating P-type atpase
EPY81_RS07135	COG2205	protein histidine kinase activity
EPY81_RS07150	COG2132	Multicopper oxidase
EPY81_RS07175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPY81_RS07200	COG0789	Transcriptional regulator
EPY81_RS07235	COG2814	Major facilitator Superfamily
EPY81_RS07245	COG0697	spore germination
EPY81_RS07250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPY81_RS07255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPY81_RS07260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EPY81_RS07280	COG3622	Belongs to the hyi family
EPY81_RS07285	COG2084	Dehydrogenase
EPY81_RS07290	COG1024	Enoyl-CoA hydratase
EPY81_RS07295	COG0784	Response regulator, receiver
EPY81_RS07295	COG5002	protein histidine kinase activity
EPY81_RS07295	COG2205	protein histidine kinase activity
EPY81_RS07300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPY81_RS07315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPY81_RS07320	COG4221	oxidoreductase activity
EPY81_RS07325	COG3956	TIGRFAM MazG family protein
EPY81_RS07330	COG1555	photosystem II stabilization
EPY81_RS07335	COG0617	tRNA 3'-terminal CCA addition
EPY81_RS07340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPY81_RS07360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPY81_RS07365	COG3028	Belongs to the UPF0307 family
EPY81_RS07370	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_RS07385	COG0625	glutathione transferase activity
EPY81_RS07390	COG1238	metal cluster binding
EPY81_RS07405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPY81_RS07410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPY81_RS07430	COG0072	phenylalanine-tRNA ligase activity
EPY81_RS07460	COG0248	Ppx GppA phosphatase
EPY81_RS07470	COG0037	tRNA processing
EPY81_RS07510	COG1764	response to oxidative stress
EPY81_RS07515	COG1846	Transcriptional regulator
EPY81_RS07525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPY81_RS07585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPY81_RS07590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPY81_RS07595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPY81_RS07655	COG1214	PFAM Peptidase M22, glycoprotease
EPY81_RS07680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPY81_RS07685	COG0561	phosphatase activity
EPY81_RS07695	COG2132	Multicopper oxidase
EPY81_RS07715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPY81_RS07720	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EPY81_RS07725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPY81_RS07755	COG1063	alcohol dehydrogenase
EPY81_RS07760	COG0583	DNA-binding transcription factor activity
EPY81_RS07765	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS07770	COG2814	Major facilitator Superfamily
EPY81_RS07775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EPY81_RS07785	COG1309	transcriptional regulator
EPY81_RS07800	COG1053	succinate dehydrogenase
EPY81_RS07805	COG0583	DNA-binding transcription factor activity
EPY81_RS07830	COG0583	DNA-binding transcription factor activity
EPY81_RS07870	COG0583	DNA-binding transcription factor activity
EPY81_RS07880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPY81_RS07885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_RS07950	COG0438	transferase activity, transferring glycosyl groups
EPY81_RS07955	COG0110	maltose O-acetyltransferase activity
EPY81_RS07995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPY81_RS08010	COG0745	RESPONSE REGULATOR receiver
EPY81_RS08015	COG2205	protein histidine kinase activity
EPY81_RS08025	COG2199	diguanylate cyclase activity
EPY81_RS08050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EPY81_RS08080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPY81_RS08085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPY81_RS08105	COG0583	DNA-binding transcription factor activity
EPY81_RS08125	COG0668	transmembrane transport
EPY81_RS08135	COG2081	HI0933 family
EPY81_RS08140	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EPY81_RS08175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPY81_RS08175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPY81_RS08185	COG0489	protein tyrosine kinase activity
EPY81_RS08190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPY81_RS08235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPY81_RS08245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPY81_RS08260	COG0730	response to heat
EPY81_RS08270	COG1196	nuclear chromosome segregation
EPY81_RS08290	COG2223	nitrite transmembrane transporter activity
EPY81_RS08295	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EPY81_RS08305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPY81_RS08305	COG0596	Alpha beta hydrolase
EPY81_RS08305	COG2226	methyltransferase
EPY81_RS08320	COG4106	trans-aconitate 2-methyltransferase activity
EPY81_RS08335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EPY81_RS08340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EPY81_RS08345	COG0009	L-threonylcarbamoyladenylate synthase
EPY81_RS08350	COG3101	peptidyl-lysine hydroxylation
EPY81_RS08355	COG1399	metal-binding, possibly nucleic acid-binding protein
EPY81_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS08380	COG1652	LysM domain
EPY81_RS08385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPY81_RS08385	COG0352	thiamine-phosphate diphosphorylase activity
EPY81_RS08385	COG0351	phosphomethylpyrimidine kinase
EPY81_RS08395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPY81_RS08425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPY81_RS08455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EPY81_RS08470	COG0358	DNA primase activity
EPY81_RS08505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPY81_RS08525	COG0583	DNA-binding transcription factor activity
EPY81_RS08530	COG0473	3-isopropylmalate dehydrogenase activity
EPY81_RS08545	COG4638	Rieske (2fe-2S)
EPY81_RS08550	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS08570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPY81_RS08570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPY81_RS08595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EPY81_RS08605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPY81_RS08610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPY81_RS08625	COG0456	acetyltransferase
EPY81_RS08635	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPY81_RS08640	COG0492	ferredoxin-NADP+ reductase activity
EPY81_RS08645	COG1674	ftsk spoiiie
EPY81_RS08650	COG1280	lysine exporter protein (LysE YggA)
EPY81_RS08665	COG2894	cell division
EPY81_RS08680	COG0204	Acyl-transferase
EPY81_RS08685	COG2885	chlorophyll binding
EPY81_RS08690	COG0210	DNA helicase
EPY81_RS08700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPY81_RS08715	COG0121	glutamine amidotransferase
EPY81_RS08730	COG2914	Belongs to the UPF0125 (RnfH) family
EPY81_RS08735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPY81_RS08740	COG0735	belongs to the Fur family
EPY81_RS08765	COG0420	3'-5' exonuclease activity
EPY81_RS08785	COG1090	epimerase
EPY81_RS08800	COG2050	protein possibly involved in aromatic compounds catabolism
EPY81_RS08810	COG2814	Major facilitator Superfamily
EPY81_RS08815	COG0405	Gamma-glutamyltransferase
EPY81_RS08825	COG0582	viral genome integration into host DNA
EPY81_RS08865	COG0629	single-stranded DNA binding
EPY81_RS08885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPY81_RS08900	COG1401	restriction endodeoxyribonuclease activity
EPY81_RS08970	COG0477	Major facilitator Superfamily
EPY81_RS08975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPY81_RS09025	COG0531	amino acid
EPY81_RS09030	COG2040	homocysteine
EPY81_RS09055	COG1309	transcriptional regulator
EPY81_RS09060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPY81_RS09065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPY81_RS09075	COG1607	acyl-coa hydrolase
EPY81_RS09085	COG0523	cobalamin synthesis protein
EPY81_RS09095	COG4681	YaeQ
EPY81_RS09105	COG0726	polysaccharide deacetylase
EPY81_RS09105	COG1649	PFAM Uncharacterised BCR, COG1649
EPY81_RS09110	COG1215	transferase activity, transferring glycosyl groups
EPY81_RS09135	COG1414	Transcriptional regulator
EPY81_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS09165	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_RS09170	COG2271	Major facilitator Superfamily
EPY81_RS09180	COG2267	carboxylic ester hydrolase activity
EPY81_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS09200	COG0028	Belongs to the TPP enzyme family
EPY81_RS09210	COG0477	Major facilitator Superfamily
EPY81_RS09215	COG0242	peptide deformylase activity
EPY81_RS09220	COG2066	Belongs to the glutaminase family
EPY81_RS09225	COG2207	Transcriptional regulator
EPY81_RS09225	COG0662	Cupin 2, conserved barrel domain protein
EPY81_RS09230	COG2223	nitrite transmembrane transporter activity
EPY81_RS09245	COG0583	DNA-binding transcription factor activity
EPY81_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS09255	COG2271	Major facilitator Superfamily
EPY81_RS09260	COG3959	Transketolase, thiamine diphosphate binding domain
EPY81_RS09265	COG3958	Transketolase
EPY81_RS09275	COG0306	phosphate transporter
EPY81_RS09295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPY81_RS09340	COG4181	ATPase activity
EPY81_RS09345	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPY81_RS09375	COG0583	DNA-binding transcription factor activity
EPY81_RS09380	COG2267	carboxylic ester hydrolase activity
EPY81_RS09385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_RS09390	COG1773	rubredoxin
EPY81_RS09440	COG2851	Citrate transporter
EPY81_RS09445	COG1253	flavin adenine dinucleotide binding
EPY81_RS09460	COG3015	lipoprotein NlpE involved in copper resistance
EPY81_RS09485	COG0804	urea catabolic process
EPY81_RS09495	COG0830	nickel cation binding
EPY81_RS09510	COG0742	ribosomal rna small subunit methyltransferase
EPY81_RS09515	COG0768	penicillin binding
EPY81_RS09540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPY81_RS09545	COG2878	Part of a membrane complex involved in electron transport
EPY81_RS09550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPY81_RS09560	COG3384	dioxygenase
EPY81_RS09575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPY81_RS09615	COG0006	proline dipeptidase activity
EPY81_RS09620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_RS09625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_RS09635	COG0789	Transcriptional regulator
EPY81_RS09645	COG1279	arginine transmembrane transporter activity
EPY81_RS09650	COG0583	DNA-binding transcription factor activity
EPY81_RS09690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPY81_RS09695	COG0741	lytic transglycosylase activity
EPY81_RS09695	COG0741	lytic transglycosylase activity
EPY81_RS09695	COG1388	LysM domain
EPY81_RS09695	COG1388	LysM domain
EPY81_RS09700	COG4166	transmembrane transport
EPY81_RS09705	COG4174	ABC transporter (Permease)
EPY81_RS09710	COG4239	(ABC) transporter, permease
EPY81_RS09715	COG4172	Belongs to the ABC transporter superfamily
EPY81_RS09740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPY81_RS09750	COG2203	Gaf domain
EPY81_RS09750	COG3706	GGDEF domain
EPY81_RS09750	COG5001	Diguanylate cyclase
EPY81_RS09750	COG4251	negative regulation of phosphorylation
EPY81_RS09760	COG1902	pentaerythritol trinitrate reductase activity
EPY81_RS09760	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_RS09770	COG0582	viral genome integration into host DNA
EPY81_RS09875	COG2814	Major facilitator Superfamily
EPY81_RS09890	COG1230	cation diffusion facilitator family transporter
EPY81_RS09900	COG2059	Chromate
EPY81_RS09930	COG4269	membrane
EPY81_RS09970	COG1113	amino acid transport
EPY81_RS09980	COG0531	amino acid
EPY81_RS10000	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS10020	COG1113	amino acid transport
EPY81_RS10025	COG2831	hemolysin activation secretion protein
EPY81_RS10030	COG3210	domain, Protein
EPY81_RS10050	COG0697	spore germination
EPY81_RS10055	COG2721	sulfolactate sulfo-lyase activity
EPY81_RS10060	COG2271	Major facilitator Superfamily
EPY81_RS10065	COG4948	Mandelate Racemase Muconate Lactonizing
EPY81_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS10080	COG2186	Transcriptional regulator
EPY81_RS10105	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS10115	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS10120	COG1024	Enoyl-CoA hydratase
EPY81_RS10125	COG2814	Major facilitator Superfamily
EPY81_RS10145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_RS10160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPY81_RS10180	COG1944	ATP diphosphatase activity
EPY81_RS10210	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EPY81_RS10215	COG2072	flavoprotein involved in K transport
EPY81_RS10230	COG1309	transcriptional regulator
EPY81_RS10235	COG1741	Belongs to the pirin family
EPY81_RS10245	COG2252	PERMEase
EPY81_RS10250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPY81_RS10255	COG3038	cytochrome b561
EPY81_RS10265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPY81_RS10325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPY81_RS10330	COG4197	protein conserved in bacteria, prophage-related
EPY81_RS10415	COG5410	chromosome segregation
EPY81_RS10430	COG3567	Phage-associated protein, HI1409 family
EPY81_RS10450	COG3566	protein conserved in bacteria
EPY81_RS10555	COG2194	sulfuric ester hydrolase activity
EPY81_RS10570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPY81_RS10585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPY81_RS10600	COG0667	Aldo Keto reductase
EPY81_RS10615	COG1765	OsmC-like protein
EPY81_RS10630	COG0542	response to heat
EPY81_RS10665	COG2885	chlorophyll binding
EPY81_RS10675	COG0625	glutathione transferase activity
EPY81_RS10705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPY81_RS10725	COG3634	alkyl hydroperoxide reductase activity
EPY81_RS10745	COG0450	alkyl hydroperoxide reductase
EPY81_RS10750	COG1643	Atp-dependent helicase
EPY81_RS10765	COG2814	Major facilitator Superfamily
EPY81_RS10770	COG3135	benzoate transporter
EPY81_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS10780	COG0633	Ferredoxin
EPY81_RS10780	COG0543	2 iron, 2 sulfur cluster binding
EPY81_RS10785	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EPY81_RS10790	COG4638	Rieske (2fe-2S)
EPY81_RS10800	COG0583	DNA-binding transcription factor activity
EPY81_RS10810	COG2871	sodium ion transport
EPY81_RS10895	COG1570	exodeoxyribonuclease VII activity
EPY81_RS10945	COG1560	Kdo2-lipid A biosynthetic process
EPY81_RS10950	COG1278	Cold shock
EPY81_RS10975	COG1011	Hydrolase
EPY81_RS10980	COG2226	methyltransferase
EPY81_RS11005	COG1309	transcriptional regulator
EPY81_RS11050	COG0668	transmembrane transport
EPY81_RS11060	COG2814	Major facilitator Superfamily
EPY81_RS11065	COG1733	regulation of RNA biosynthetic process
EPY81_RS11115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EPY81_RS11125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPY81_RS11130	COG1137	ATPase activity
EPY81_RS11135	COG1538	Outer membrane efflux protein
EPY81_RS11165	COG4122	O-methyltransferase activity
EPY81_RS11175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EPY81_RS11190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPY81_RS11205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPY81_RS11210	COG0531	amino acid
EPY81_RS11215	COG1522	sequence-specific DNA binding
EPY81_RS11230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPY81_RS11240	COG1469	GTP cyclohydrolase I activity
EPY81_RS11255	COG1733	regulation of RNA biosynthetic process
EPY81_RS11260	COG0753	catalase activity
EPY81_RS11265	COG3038	cytochrome b561
EPY81_RS11370	COG3220	belongs to the UPF0276 family
EPY81_RS11380	COG1595	DNA-templated transcription, initiation
EPY81_RS11395	COG1914	H( )-stimulated, divalent metal cation uptake system
EPY81_RS11415	COG4770	biotin carboxylase activity
EPY81_RS11420	COG0038	chloride channel
EPY81_RS11425	COG2831	hemolysin activation secretion protein
EPY81_RS11430	COG3210	domain, Protein
EPY81_RS11460	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPY81_RS11465	COG1063	alcohol dehydrogenase
EPY81_RS11480	COG0439	Biotin carboxylase
EPY81_RS11485	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPY81_RS11490	COG1733	regulation of RNA biosynthetic process
EPY81_RS11500	COG0864	Transcriptional regulator
EPY81_RS11510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_RS11515	COG1116	anion transmembrane transporter activity
EPY81_RS11530	COG0477	Major facilitator Superfamily
EPY81_RS11560	COG0583	DNA-binding transcription factor activity
EPY81_RS11565	COG0666	response to abiotic stimulus
EPY81_RS11570	COG0590	tRNA wobble adenosine to inosine editing
EPY81_RS11575	COG2807	transmembrane transport
EPY81_RS11590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_RS11595	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPY81_RS11605	COG0789	Transcriptional regulator
EPY81_RS11625	COG1760	l-serine dehydratase
EPY81_RS11630	COG2030	dehydratase
EPY81_RS11630	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS11635	COG3396	Phenylacetate-CoA oxygenase
EPY81_RS11640	COG3460	Phenylacetate-CoA oxygenase
EPY81_RS11645	COG3396	Phenylacetate-CoA oxygenase
EPY81_RS11650	COG2151	metal-sulfur cluster biosynthetic enzyme
EPY81_RS11655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_RS11660	COG1024	Enoyl-CoA hydratase
EPY81_RS11665	COG1024	Enoyl-CoA hydratase
EPY81_RS11670	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPY81_RS11675	COG0183	Belongs to the thiolase family
EPY81_RS11680	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EPY81_RS11685	COG3327	negative regulation of DNA-templated transcription, initiation
EPY81_RS11695	COG2050	protein possibly involved in aromatic compounds catabolism
EPY81_RS11730	COG0583	DNA-binding transcription factor activity
EPY81_RS11740	COG1414	Transcriptional regulator
EPY81_RS11745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_RS11765	COG1840	ABC-type Fe3 transport system, periplasmic component
EPY81_RS11770	COG3842	ATPase activity
EPY81_RS11785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPY81_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPY81_RS11795	COG2814	Major facilitator Superfamily
EPY81_RS11800	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS11815	COG1024	Enoyl-CoA hydratase
EPY81_RS11825	COG2814	Major facilitator Superfamily
EPY81_RS11835	COG0183	Belongs to the thiolase family
EPY81_RS11840	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPY81_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS11850	COG1024	Enoyl-CoA hydratase
EPY81_RS11855	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS11860	COG2814	Major facilitator Superfamily
EPY81_RS11865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPY81_RS11870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPY81_RS11880	COG2814	Major facilitator Superfamily
EPY81_RS11890	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS11905	COG0583	DNA-binding transcription factor activity
EPY81_RS11920	COG1024	Enoyl-CoA hydratase
EPY81_RS11925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPY81_RS11930	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS11935	COG1309	transcriptional regulator
EPY81_RS11940	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_RS11955	COG2814	Major facilitator Superfamily
EPY81_RS11965	COG0583	DNA-binding transcription factor activity
EPY81_RS12020	COG0776	regulation of translation
EPY81_RS12110	COG4373	Mu-like prophage FluMu protein gp28
EPY81_RS12115	COG4383	Mu-like prophage protein gp29
EPY81_RS12120	COG2369	cell adhesion
EPY81_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS12275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPY81_RS12295	COG2205	protein histidine kinase activity
EPY81_RS12295	COG0784	Response regulator, receiver
EPY81_RS12315	COG0765	amino acid transport
EPY81_RS12320	COG0765	amino acid transport
EPY81_RS12330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_RS12335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_RS12345	COG1280	lysine exporter protein (LysE YggA)
EPY81_RS12355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPY81_RS12360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPY81_RS12365	COG1045	serine acetyltransferase
EPY81_RS12375	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS12380	COG0583	DNA-binding transcription factor activity
EPY81_RS12400	COG0625	glutathione transferase activity
EPY81_RS12405	COG0625	glutathione transferase activity
EPY81_RS12410	COG0583	DNA-binding transcription factor activity
EPY81_RS12420	COG1346	cytolysis
EPY81_RS12445	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EPY81_RS12450	COG3052	prosthetic group binding
EPY81_RS12470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPY81_RS12490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_RS12500	COG1294	oxidase, subunit
EPY81_RS12505	COG1271	oxidase subunit
EPY81_RS12525	COG0477	Major facilitator Superfamily
EPY81_RS12535	COG4521	taurine ABC transporter
EPY81_RS12540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EPY81_RS12545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_RS12550	COG2175	clavaminate synthase activity
EPY81_RS12560	COG1953	Uracil, thiamine, allantoin
EPY81_RS12570	COG0583	DNA-binding transcription factor activity
EPY81_RS12580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EPY81_RS12595	COG0640	Transcriptional regulator
EPY81_RS12605	COG0798	PFAM Bile acid sodium symporter
EPY81_RS12610	COG0431	NADPH-dependent FMN reductase
EPY81_RS12615	COG0583	DNA-binding transcription factor activity
EPY81_RS12630	COG3634	alkyl hydroperoxide reductase activity
EPY81_RS12665	COG1301	dicarboxylic acid transport
EPY81_RS12670	COG0436	Aminotransferase
EPY81_RS12680	COG0386	Belongs to the glutathione peroxidase family
EPY81_RS12720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EPY81_RS12745	COG0012	GTP binding
EPY81_RS12750	COG2011	ABC-type metal ion transport system permease component
EPY81_RS12755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPY81_RS12765	COG1464	Belongs to the NlpA lipoprotein family
EPY81_RS12795	COG0765	amino acid transport
EPY81_RS12800	COG0765	amino acid transport
EPY81_RS12805	COG1126	abc transporter atp-binding protein
EPY81_RS12815	COG1522	sequence-specific DNA binding
EPY81_RS12830	COG1309	transcriptional regulator
EPY81_RS12845	COG0583	DNA-binding transcription factor activity
EPY81_RS12855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPY81_RS12865	COG0697	spore germination
EPY81_RS12870	COG0583	DNA-binding transcription factor activity
EPY81_RS12905	COG3539	Fimbrial protein
EPY81_RS12930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPY81_RS12930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPY81_RS12975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPY81_RS12985	COG2353	YceI-like domain
EPY81_RS12995	COG3698	Phosphodiester glycosidase
EPY81_RS13010	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPY81_RS13015	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EPY81_RS13015	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EPY81_RS13015	COG0506	proline dehydrogenase activity
EPY81_RS13025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPY81_RS13030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPY81_RS13050	COG1132	(ABC) transporter
EPY81_RS13055	COG3122	Protein conserved in bacteria
EPY81_RS13060	COG3619	membrane
EPY81_RS13070	COG0640	Transcriptional regulator
EPY81_RS13080	COG2850	peptidyl-arginine hydroxylation
EPY81_RS13085	COG0424	maF-like protein
EPY81_RS13110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPY81_RS13120	COG3178	'Phosphotransferase
EPY81_RS13125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EPY81_RS13135	COG1192	Involved in chromosome partitioning
EPY81_RS13140	COG1475	DNA binding
EPY81_RS13145	COG0811	peptide transport
EPY81_RS13155	COG1132	(ABC) transporter
EPY81_RS13160	COG1663	tetraacyldisaccharide 4'-kinase activity
EPY81_RS13180	COG0084	hydrolase, TatD family'
EPY81_RS13225	COG0590	tRNA wobble adenosine to inosine editing
EPY81_RS13245	COG0776	regulation of translation
EPY81_RS13260	COG2431	L-lysine efflux transmembrane transporter activity
EPY81_RS13275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPY81_RS13280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPY81_RS13325	COG4166	transmembrane transport
EPY81_RS13330	COG0339	signal peptide processing
EPY81_RS13335	COG0601	transmembrane transport
EPY81_RS13375	COG0702	epimerase
EPY81_RS13380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPY81_RS13400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPY81_RS13430	COG0316	Belongs to the HesB IscA family
EPY81_RS13435	COG0822	iron-sulfur transferase activity
EPY81_RS13460	COG0776	regulation of translation
EPY81_RS13465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPY81_RS13470	COG2207	Transcriptional regulator
EPY81_RS13475	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPY81_RS13480	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS13485	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS13500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPY81_RS13525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EPY81_RS13545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPY81_RS13550	COG0730	response to heat
EPY81_RS13575	COG4773	Receptor
EPY81_RS13580	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPY81_RS13640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPY81_RS13655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPY81_RS13660	COG0583	DNA-binding transcription factor activity
EPY81_RS13690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPY81_RS13700	COG0133	tryptophan synthase activity
EPY81_RS13730	COG3706	GGDEF domain
EPY81_RS13745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPY81_RS13750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPY81_RS13755	COG0022	dehydrogenase e1 component
EPY81_RS13760	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPY81_RS13765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPY81_RS13775	COG1063	alcohol dehydrogenase
EPY81_RS13780	COG3781	membrane
EPY81_RS13790	COG3453	Protein conserved in bacteria
EPY81_RS13790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPY81_RS13800	COG0730	response to heat
EPY81_RS13820	COG3708	Transcriptional regulator
EPY81_RS13820	COG2207	Transcriptional regulator
EPY81_RS13825	COG1733	regulation of RNA biosynthetic process
EPY81_RS13830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPY81_RS13840	COG0477	Major facilitator Superfamily
EPY81_RS13850	COG1027	Aspartate ammonia-lyase
EPY81_RS13865	COG0583	DNA-binding transcription factor activity
EPY81_RS13870	COG0583	DNA-binding transcription factor activity
EPY81_RS13875	COG0183	Belongs to the thiolase family
EPY81_RS13880	COG2031	fatty acid transporter
EPY81_RS13895	COG0583	DNA-binding transcription factor activity
EPY81_RS13935	COG2610	gluconate transmembrane transporter activity
EPY81_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS13945	COG2207	Transcriptional regulator
EPY81_RS13960	COG0412	Dienelactone hydrolase
EPY81_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS13975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_RS13990	COG0543	2 iron, 2 sulfur cluster binding
EPY81_RS13990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_RS13995	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EPY81_RS14000	COG4638	Rieske (2fe-2S)
EPY81_RS14010	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPY81_RS14015	COG4149	molybdate abc transporter
EPY81_RS14020	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EPY81_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS14030	COG3433	isochorismatase activity
EPY81_RS14030	COG1535	isochorismatase
EPY81_RS14085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPY81_RS14090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_RS14095	COG0745	RESPONSE REGULATOR receiver
EPY81_RS14100	COG2205	protein histidine kinase activity
EPY81_RS14110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPY81_RS14130	COG0753	catalase activity
EPY81_RS14165	COG3539	Fimbrial protein
EPY81_RS14240	COG4628	conserved protein (DUF2132)
EPY81_RS14250	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPY81_RS14300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPY81_RS14360	COG0018	arginyl-trna synthetase
EPY81_RS14400	COG0318	PFAM AMP-dependent synthetase and ligase
EPY81_RS14410	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS14425	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS14435	COG0583	DNA-binding transcription factor activity
EPY81_RS14440	COG1309	transcriptional regulator
EPY81_RS14480	COG1902	pentaerythritol trinitrate reductase activity
EPY81_RS14480	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_RS14500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_RS14510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_RS14520	COG2186	Transcriptional regulator
EPY81_RS14525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPY81_RS14535	COG2233	PERMEase
EPY81_RS14540	COG2351	hydroxyisourate hydrolase activity
EPY81_RS14545	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS14565	COG2186	Transcriptional regulator
EPY81_RS14575	COG0583	DNA-binding transcription factor activity
EPY81_RS14580	COG4948	Mandelate Racemase Muconate Lactonizing
EPY81_RS14585	COG4829	muconolactone delta-isomerase
EPY81_RS14595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPY81_RS14600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPY81_RS14605	COG0183	Belongs to the thiolase family
EPY81_RS14610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPY81_RS14615	COG1012	belongs to the aldehyde dehydrogenase family
EPY81_RS14625	COG3733	amine oxidase
EPY81_RS14635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS14655	COG4638	Rieske (2fe-2S)
EPY81_RS14675	COG0154	amidase activity
EPY81_RS14685	COG2814	Major facilitator Superfamily
EPY81_RS14710	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS14715	COG0583	DNA-binding transcription factor activity
EPY81_RS14720	COG1414	Transcriptional regulator
EPY81_RS14735	COG2391	methyltransferase activity
EPY81_RS14745	COG4993	Dehydrogenase
EPY81_RS14750	COG3659	wide pore channel activity
EPY81_RS14755	COG3420	alginic acid biosynthetic process
EPY81_RS14760	COG0710	3-dehydroquinate dehydratase activity
EPY81_RS14765	COG3485	protocatechuate 3,4-dioxygenase
EPY81_RS14770	COG3485	protocatechuate 3,4-dioxygenase
EPY81_RS14775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPY81_RS14780	COG2271	Major facilitator Superfamily
EPY81_RS14785	COG0596	Alpha beta hydrolase
EPY81_RS14790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPY81_RS14795	COG0183	Belongs to the thiolase family
EPY81_RS14800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPY81_RS14805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPY81_RS14815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EPY81_RS14820	COG4773	Receptor
EPY81_RS14830	COG2323	membrane
EPY81_RS14835	COG0148	phosphopyruvate hydratase activity
EPY81_RS14875	COG1902	pentaerythritol trinitrate reductase activity
EPY81_RS14875	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPY81_RS14890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPY81_RS14900	COG0542	response to heat
EPY81_RS14905	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPY81_RS14935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPY81_RS14940	COG0569	domain protein
EPY81_RS14945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPY81_RS14960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPY81_RS14970	COG1585	Membrane protein implicated in regulation of membrane protease activity
EPY81_RS14985	COG1294	oxidase, subunit
EPY81_RS14990	COG4890	Cyd operon protein YbgT
EPY81_RS15015	COG0552	protein localization to endoplasmic reticulum
EPY81_RS15040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPY81_RS15040	COG0517	IMP dehydrogenase activity
EPY81_RS15045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPY81_RS15050	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPY81_RS15060	COG0583	DNA-binding transcription factor activity
EPY81_RS15065	COG0024	Methionine aminopeptidase
EPY81_RS15075	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EPY81_RS15095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPY81_RS15095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPY81_RS15100	COG1105	Belongs to the carbohydrate kinase PfkB family
EPY81_RS15105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPY81_RS15105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPY81_RS15105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPY81_RS15140	COG0659	secondary active sulfate transmembrane transporter activity
EPY81_RS15160	COG1113	amino acid transport
EPY81_RS15170	COG1522	sequence-specific DNA binding
EPY81_RS15185	COG1011	Hydrolase
EPY81_RS15190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPY81_RS15200	COG2137	regulation of response to DNA damage stimulus
EPY81_RS15215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPY81_RS15250	COG0575	Belongs to the CDS family
EPY81_RS15255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPY81_RS15280	COG3852	Histidine kinase
EPY81_RS15285	COG2204	response regulator
EPY81_RS15355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPY81_RS15380	COG0697	spore germination
EPY81_RS15385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_RS15395	COG0303	'Molybdopterin
EPY81_RS15400	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPY81_RS15400	COG0315	cyclic pyranopterin monophosphate synthase activity
EPY81_RS15415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPY81_RS15420	COG0243	molybdopterin cofactor binding
EPY81_RS15430	COG0243	molybdopterin cofactor binding
EPY81_RS15435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_RS15440	COG2146	nitrite reductase [NAD(P)H] activity
EPY81_RS15440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPY81_RS15455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_RS15455	COG1116	anion transmembrane transporter activity
EPY81_RS15460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPY81_RS15465	COG2423	ornithine cyclodeaminase activity
EPY81_RS15470	COG4264	IucA IucC family
EPY81_RS15480	COG4264	IucA IucC family
EPY81_RS15505	COG0511	ligase activity, forming carbon-carbon bonds
EPY81_RS15520	COG2814	Major facilitator Superfamily
EPY81_RS15575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPY81_RS15590	COG1335	isochorismatase
EPY81_RS15605	COG1454	alcohol dehydrogenase
EPY81_RS15610	COG0824	Thioesterase
EPY81_RS15620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPY81_RS15655	COG1028	Short-chain dehydrogenase reductase Sdr
EPY81_RS15660	COG0183	Belongs to the thiolase family
EPY81_RS15670	COG0583	DNA-binding transcription factor activity
EPY81_RS15685	COG1522	sequence-specific DNA binding
EPY81_RS15690	COG3135	benzoate transporter
EPY81_RS15715	COG0589	response to stress
EPY81_RS15720	COG0488	(ABC) transporter
EPY81_RS15755	COG0583	DNA-binding transcription factor activity
EPY81_RS15780	COG3772	lysozyme
EPY81_RS15835	COG4774	siderophore transport
EPY81_RS15840	COG4772	TonB-dependent receptor
EPY81_RS15855	COG1605	Chorismate mutase
EPY81_RS15895	COG0308	aminopeptidase N
EPY81_RS15920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPY81_RS15925	COG1454	alcohol dehydrogenase
EPY81_RS15945	COG0531	amino acid
EPY81_RS15950	COG4303	Ethanolamine ammonia lyase large subunit
EPY81_RS15955	COG4302	ethanolamine ammonia-lyase activity
EPY81_RS15960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPY81_RS15960	COG0519	Catalyzes the synthesis of GMP from XMP
EPY81_RS15965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPY81_RS15975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPY81_RS15990	COG0697	spore germination
EPY81_RS15995	COG1923	regulation of RNA biosynthetic process
EPY81_RS16005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPY81_RS16010	COG0802	atpase or kinase
EPY81_RS16030	COG1187	pseudouridine synthase activity
EPY81_RS16045	COG0583	DNA-binding transcription factor activity
EPY81_RS16145	COG2369	cell adhesion
EPY81_RS16165	COG4373	Mu-like prophage FluMu protein gp28
EPY81_RS16200	COG0681	Belongs to the peptidase S26 family
EPY81_RS16225	COG3409	Peptidoglycan-binding domain 1 protein
EPY81_RS16225	COG3267	Type II secretory pathway component ExeA
EPY81_RS16250	COG0776	regulation of translation
EPY81_RS16285	COG2814	Major facilitator Superfamily
EPY81_RS16290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPY81_RS16320	COG0729	surface antigen
EPY81_RS16325	COG0477	Major facilitator Superfamily
EPY81_RS16340	COG0174	glutamine synthetase
EPY81_RS16345	COG0745	RESPONSE REGULATOR receiver
EPY81_RS16350	COG2205	protein histidine kinase activity
EPY81_RS16355	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EPY81_RS16360	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EPY81_RS16365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EPY81_RS16375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPY81_RS16390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPY81_RS16395	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS16410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPY81_RS16415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPY81_RS16420	COG2890	protein-(glutamine-N5) methyltransferase activity
EPY81_RS16435	COG0583	DNA-binding transcription factor activity
EPY81_RS16450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPY81_RS16460	COG3658	cytochrome
EPY81_RS16465	COG1215	transferase activity, transferring glycosyl groups
EPY81_RS16470	COG0726	polysaccharide deacetylase
EPY81_RS16470	COG1649	PFAM Uncharacterised BCR, COG1649
EPY81_RS16500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPY81_RS16505	COG1845	cytochrome c oxidase, subunit III
EPY81_RS16510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPY81_RS16535	COG0305	Participates in initiation and elongation during chromosome replication
EPY81_RS16540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPY81_RS16550	COG1305	Transglutaminase-like
EPY81_RS16560	COG2308	Evidence 4 Homologs of previously reported genes of
EPY81_RS16590	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPY81_RS16600	COG0151	Belongs to the GarS family
EPY81_RS16610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPY81_RS16615	COG2011	ABC-type metal ion transport system permease component
EPY81_RS16620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPY81_RS16630	COG1301	dicarboxylic acid transport
EPY81_RS16660	COG1794	racemase activity, acting on amino acids and derivatives
EPY81_RS16675	COG0745	RESPONSE REGULATOR receiver
EPY81_RS16680	COG0642	Histidine kinase
EPY81_RS16685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPY81_RS16695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPY81_RS16735	COG2351	hydroxyisourate hydrolase activity
EPY81_RS16745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPY81_RS16745	COG3008	intermembrane lipid transfer
EPY81_RS16750	COG2995	paraquat-inducible protein a
EPY81_RS16760	COG2985	domain, Protein
EPY81_RS16770	COG1309	transcriptional regulator
EPY81_RS16785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPY81_RS16785	COG0475	glutathione-regulated potassium exporter activity
EPY81_RS16790	COG0786	glutamate:sodium symporter activity
EPY81_RS16795	COG3243	poly(R)-hydroxyalkanoic acid synthase
EPY81_RS16810	COG1278	Cold shock
EPY81_RS16860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPY81_RS16865	COG1610	YqeY-like protein
EPY81_RS16870	COG4783	chaperone-mediated protein folding
EPY81_RS16895	COG1286	toxin biosynthetic process
EPY81_RS16925	COG0778	Nitroreductase
EPY81_RS16935	COG0513	Belongs to the DEAD box helicase family
EPY81_RS16955	COG2363	Small membrane protein
EPY81_RS16985	COG4650	regulator
EPY81_RS16990	COG1234	tRNA 3'-trailer cleavage
EPY81_RS16995	COG1690	Belongs to the RtcB family
EPY81_RS17015	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPY81_RS17025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPY81_RS17040	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS17045	COG1301	dicarboxylic acid transport
EPY81_RS17055	COG3139	Protein of unknown function (DUF1315)
EPY81_RS17060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPY81_RS17065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPY81_RS17075	COG0494	nUDIX hydrolase
EPY81_RS17085	COG0642	Histidine kinase
EPY81_RS17090	COG0745	RESPONSE REGULATOR receiver
EPY81_RS17110	COG1720	tRNA m6t6A37 methyltransferase activity
EPY81_RS17120	COG0384	phenazine biosynthesis protein PhzF
EPY81_RS17125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPY81_RS17135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPY81_RS17145	COG4598	ABC transporter
EPY81_RS17150	COG4160	amino acid transport
EPY81_RS17155	COG4215	(ABC) transporter
EPY81_RS17160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPY81_RS17170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_RS17180	COG1538	Outer membrane efflux protein
EPY81_RS17215	COG1131	(ABC) transporter
EPY81_RS17220	COG0842	Transport permease protein
EPY81_RS17235	COG0772	Belongs to the SEDS family
EPY81_RS17240	COG2951	lytic endotransglycosylase activity
EPY81_RS17265	COG2207	Transcriptional regulator
EPY81_RS17280	COG0052	Belongs to the universal ribosomal protein uS2 family
EPY81_RS17285	COG0024	Methionine aminopeptidase
EPY81_RS17295	COG2223	nitrite transmembrane transporter activity
EPY81_RS17305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPY81_RS17310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPY81_RS17315	COG1960	acyl-CoA dehydrogenase activity
EPY81_RS17330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EPY81_RS17335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPY81_RS17340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPY81_RS17360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPY81_RS17365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPY81_RS17370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EPY81_RS17405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPY81_RS17420	COG3104	oligopeptide transport
EPY81_RS17430	COG0582	viral genome integration into host DNA
EPY81_RS17475	COG3179	chitinase
EPY81_RS17515	COG2314	TM2 domain
EPY81_RS17575	COG3566	protein conserved in bacteria
EPY81_RS17595	COG3567	Phage-associated protein, HI1409 family
EPY81_RS17600	COG5410	chromosome segregation
EPY81_RS17685	COG4197	protein conserved in bacteria, prophage-related
EPY81_RS17690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPY81_RS17740	COG0512	Glutamine amidotransferase of anthranilate synthase
EPY81_RS17745	COG0308	aminopeptidase N
EPY81_RS17750	COG4771	TonB-dependent receptor
EPY81_RS17765	COG2840	Smr protein MutS2
EPY81_RS17775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPY81_RS17785	COG0302	gtp cyclohydrolase
EPY81_RS17805	COG3739	integral membrane protein
EPY81_RS17820	COG1169	isochorismate synthase
EPY81_RS17830	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EPY81_RS17840	COG1132	(ABC) transporter
EPY81_RS17855	COG3433	isochorismatase activity
EPY81_RS17855	COG1535	isochorismatase
EPY81_RS17860	COG1021	2,3-dihydroxybenzoate-AMP ligase
EPY81_RS17865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPY81_RS17875	COG4774	siderophore transport
EPY81_RS17880	COG4607	ABC-type enterochelin transport system periplasmic component
EPY81_RS17885	COG4604	ABC transporter, ATP-binding protein
EPY81_RS17890	COG4605	iron ion homeostasis
EPY81_RS17895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPY81_RS17900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPY81_RS17915	COG1741	Belongs to the pirin family
EPY81_RS18000	COG0582	viral genome integration into host DNA
EPY81_RS18010	COG2879	small protein
EPY81_RS18015	COG1966	Carbon starvation protein
EPY81_RS18020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPY81_RS18055	COG2211	Major facilitator Superfamily
EPY81_RS18060	COG1067	ATP-dependent peptidase activity
EPY81_RS18065	COG0583	DNA-binding transcription factor activity
EPY81_RS18090	COG1686	Belongs to the peptidase S11 family
EPY81_RS18095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPY81_RS18135	COG0616	signal peptide processing
EPY81_RS18140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPY81_RS18150	COG0573	inorganic phosphate transmembrane transporter activity
EPY81_RS18155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPY81_RS18160	COG1113	amino acid transport
EPY81_RS18165	COG3961	Belongs to the TPP enzyme family
EPY81_RS18170	COG1522	sequence-specific DNA binding
EPY81_RS18180	COG0076	glutamate decarboxylase activity
EPY81_RS18185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPY81_RS18200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPY81_RS18235	COG0352	thiamine-phosphate diphosphorylase activity
EPY81_RS18260	COG0612	Peptidase, M16
EPY81_RS18275	COG0583	DNA-binding transcription factor activity
EPY81_RS18280	COG0477	Major facilitator Superfamily
EPY81_RS18295	COG1187	pseudouridine synthase activity
EPY81_RS18310	COG1686	Belongs to the peptidase S11 family
EPY81_RS18315	COG1252	NADH dehydrogenase
EPY81_RS18325	COG0415	Belongs to the DNA photolyase family
EPY81_RS18340	COG1215	transferase activity, transferring glycosyl groups
EPY81_RS18355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPY81_RS18370	COG2070	2-Nitropropane dioxygenase
EPY81_RS18415	COG2962	Rard protein
EPY81_RS18425	COG0556	nucleotide-excision repair
EPY81_RS18475	COG4221	oxidoreductase activity
EPY81_RS18485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPY81_RS18490	COG1381	Involved in DNA repair and RecF pathway recombination
EPY81_RS18500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPY81_RS18505	COG0571	ribonuclease III activity
EPY81_RS18515	COG0681	Belongs to the peptidase S26 family
EPY81_RS18520	COG0481	GTPase activity
EPY81_RS18525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPY81_RS18535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPY81_RS18555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPY81_RS18560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPY81_RS18565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EPY81_RS18575	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EPY81_RS18580	COG4208	sulfate ABC transporter
EPY81_RS18585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EPY81_RS18590	COG0583	DNA-binding transcription factor activity
EPY81_RS18595	COG4625	pathogenesis
EPY81_RS18610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPY81_RS18625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPY81_RS18640	COG1051	belongs to the nudix hydrolase family
EPY81_RS18640	COG1056	cytidyltransferase-related domain
EPY81_RS18645	COG1024	Enoyl-CoA hydratase
EPY81_RS18650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPY81_RS18655	COG2814	Major facilitator Superfamily
EPY81_RS18660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPY81_RS18660	COG0047	phosphoribosylformylglycinamidine synthase activity
EPY81_RS18680	COG1473	amidohydrolase
EPY81_RS18685	COG0824	Thioesterase
EPY81_RS18705	COG0823	Involved in the tonB-independent uptake of proteins
EPY81_RS18725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPY81_RS18760	COG0628	permease
EPY81_RS18770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPY81_RS18775	COG0596	Alpha beta hydrolase
EPY81_RS18780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPY81_RS18780	COG0616	signal peptide processing
EPY81_RS18790	COG0658	competence protein
EPY81_RS18790	COG2333	competence protein COMEC
EPY81_RS18795	COG1136	(ABC) transporter
EPY81_RS18800	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPY81_RS18830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_RS18860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPY81_RS18865	COG1280	lysine exporter protein (LysE YggA)
EPY81_RS18875	COG0019	diaminopimelate decarboxylase activity
EPY81_RS18885	COG1113	amino acid transport
EPY81_RS18890	COG1115	amino acid carrier protein
EPY81_RS18905	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPY81_RS18915	COG3339	Conserved Protein
EPY81_RS18920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPY81_RS18925	COG0243	molybdopterin cofactor binding
EPY81_RS18930	COG1929	Belongs to the glycerate kinase type-1 family
EPY81_RS18945	COG0778	Nitroreductase
EPY81_RS18955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPY81_RS18990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPY81_RS18995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPY81_RS19020	COG0741	lytic transglycosylase activity
EPY81_RS19040	COG0584	glycerophosphoryl diester phosphodiesterase
EPY81_RS19070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EPY81_RS19090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPY81_RS19095	COG0477	Major facilitator Superfamily
EPY81_RS19105	COG2264	protein methyltransferase activity
EPY81_RS19145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPY81_RS19150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPY81_RS19180	COG0505	Belongs to the CarA family
EPY81_RS19195	COG1309	transcriptional regulator
EPY81_RS19200	COG0251	oxidation-reduction process
EPY81_RS19210	COG0589	response to stress
EPY81_RS19230	COG2843	Capsule synthesis protein