locus-tag	class	description
C2U64_RS00020	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_RS00060	COG1660	Displays ATPase and GTPase activities
C2U64_RS00095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U64_RS00140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U64_RS00255	COG2184	nucleotidyltransferase activity
C2U64_RS00290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U64_RS00330	COG0582	viral genome integration into host DNA
C2U64_RS00355	COG3621	Patatin-like phospholipase
C2U64_RS00395	COG2801	Transposase and inactivated derivatives
C2U64_RS00415	COG1570	exodeoxyribonuclease VII activity
C2U64_RS00425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U64_RS00435	COG2801	Transposase and inactivated derivatives
C2U64_RS00445	COG2801	Transposase and inactivated derivatives
C2U64_RS00455	COG3173	Aminoglycoside phosphotransferase
C2U64_RS00460	COG0488	(ABC) transporter
C2U64_RS00480	COG2801	Transposase and inactivated derivatives
C2U64_RS00495	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U64_RS00500	COG3657	addiction module killer protein
C2U64_RS00525	COG2801	Transposase and inactivated derivatives
C2U64_RS00535	COG2801	Transposase and inactivated derivatives
C2U64_RS00575	COG3077	Addiction module antitoxin, RelB DinJ family
C2U64_RS00590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U64_RS00650	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_RS00655	COG0589	response to stress
C2U64_RS00690	COG0604	alcohol dehydrogenase
C2U64_RS00720	COG0582	viral genome integration into host DNA
C2U64_RS00735	COG2130	NADP-dependent
C2U64_RS00740	COG1309	transcriptional regulator
C2U64_RS00750	COG1902	pentaerythritol trinitrate reductase activity
C2U64_RS00760	COG1979	alcohol dehydrogenase
C2U64_RS00775	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2U64_RS00805	COG0477	Major facilitator Superfamily
C2U64_RS00810	COG0697	spore germination
C2U64_RS00820	COG0604	alcohol dehydrogenase
C2U64_RS00820	COG3321	synthase
C2U64_RS00825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C2U64_RS00830	COG0583	DNA-binding transcription factor activity
C2U64_RS00835	COG4221	oxidoreductase activity
C2U64_RS00860	COG2801	Transposase and inactivated derivatives
C2U64_RS00880	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_RS00910	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U64_RS00910	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U64_RS00960	COG2184	nucleotidyltransferase activity
C2U64_RS00995	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_RS01105	COG1785	Belongs to the alkaline phosphatase family
C2U64_RS01110	COG1475	DNA binding
C2U64_RS01115	COG1192	Involved in chromosome partitioning
C2U64_RS01140	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U64_RS01165	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_RS01170	COG0589	response to stress
C2U64_RS01190	COG0592	DNA-directed DNA polymerase activity
C2U64_RS01200	COG0187	DNA topoisomerase II activity
C2U64_RS01215	COG0488	(ABC) transporter
C2U64_RS01240	COG0596	Alpha beta hydrolase
C2U64_RS01245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U64_RS01250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U64_RS01285	COG0625	glutathione transferase activity
C2U64_RS01295	COG0733	neurotransmitter:sodium symporter activity
C2U64_RS01335	COG2233	PERMEase
C2U64_RS01350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_RS01385	COG2814	Major facilitator Superfamily
C2U64_RS01390	COG0656	L-ascorbic acid biosynthetic process
C2U64_RS01395	COG0583	DNA-binding transcription factor activity
C2U64_RS01410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_RS01415	COG1064	alcohol dehydrogenase
C2U64_RS01420	COG2818	Glycosylase
C2U64_RS01435	COG1194	a g-specific adenine glycosylase
C2U64_RS01450	COG5487	UPF0391 membrane protein
C2U64_RS01455	COG2983	Belongs to the UPF0260 family
C2U64_RS01460	COG2133	pyrroloquinoline quinone binding
C2U64_RS01465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U64_RS01470	COG2116	formate transmembrane transporter activity
C2U64_RS01490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U64_RS01495	COG1335	isochorismatase
C2U64_RS01500	COG0385	Bile acid
C2U64_RS01505	COG0534	Mate efflux family protein
C2U64_RS01510	COG1683	Conserved Protein
C2U64_RS01525	COG0346	lactoylglutathione lyase activity
C2U64_RS01530	COG0625	glutathione transferase activity
C2U64_RS01540	COG1113	amino acid transport
C2U64_RS01550	COG0523	cobalamin synthesis protein
C2U64_RS01560	COG2188	Transcriptional regulator
C2U64_RS01590	COG0010	Belongs to the arginase family
C2U64_RS01640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U64_RS01650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U64_RS01655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U64_RS01765	COG0534	Mate efflux family protein
C2U64_RS01770	COG0436	Aminotransferase
C2U64_RS01775	COG2733	membrane
C2U64_RS01790	COG2918	glutathione biosynthetic process
C2U64_RS01845	COG3150	esterase
C2U64_RS01855	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C2U64_RS01865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_RS01875	COG2233	PERMEase
C2U64_RS01880	COG2351	hydroxyisourate hydrolase activity
C2U64_RS01915	COG3706	GGDEF domain
C2U64_RS01920	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS01935	COG1393	Belongs to the ArsC family
C2U64_RS01940	COG0708	Exodeoxyribonuclease III
C2U64_RS01960	COG0189	ligase activity
C2U64_RS01980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U64_RS01990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U64_RS02005	COG4942	peptidase
C2U64_RS02015	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U64_RS02025	COG2119	membrane
C2U64_RS02030	COG4774	siderophore transport
C2U64_RS02035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_RS02035	COG0426	domain, Protein
C2U64_RS02055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U64_RS02075	COG1902	pentaerythritol trinitrate reductase activity
C2U64_RS02080	COG1519	Transferase
C2U64_RS02085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U64_RS02090	COG0668	transmembrane transport
C2U64_RS02100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U64_RS02105	COG1335	isochorismatase
C2U64_RS02110	COG1522	sequence-specific DNA binding
C2U64_RS02115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_RS02135	COG2205	protein histidine kinase activity
C2U64_RS02135	COG2198	Histidine kinase
C2U64_RS02135	COG0784	Response regulator, receiver
C2U64_RS02140	COG3162	membrane
C2U64_RS02145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U64_RS02155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U64_RS02180	COG1309	transcriptional regulator
C2U64_RS02200	COG0300	oxidoreductase activity
C2U64_RS02205	COG0789	Transcriptional regulator
C2U64_RS02210	COG0351	phosphomethylpyrimidine kinase
C2U64_RS02210	COG0352	thiamine-phosphate diphosphorylase activity
C2U64_RS02210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U64_RS02220	COG2814	Major facilitator Superfamily
C2U64_RS02280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U64_RS02295	COG0641	radical SAM
C2U64_RS02315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2U64_RS02325	COG1113	amino acid transport
C2U64_RS02335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U64_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS02350	COG1335	isochorismatase
C2U64_RS02435	COG2814	Major facilitator Superfamily
C2U64_RS02440	COG0583	DNA-binding transcription factor activity
C2U64_RS02460	COG0667	Aldo Keto reductase
C2U64_RS02500	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U64_RS02590	COG2814	Major facilitator Superfamily
C2U64_RS02655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U64_RS02680	COG0582	viral genome integration into host DNA
C2U64_RS02740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U64_RS02755	COG0697	spore germination
C2U64_RS02780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U64_RS02810	COG0427	acetyl-CoA hydrolase
C2U64_RS02835	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_RS02840	COG4221	oxidoreductase activity
C2U64_RS02845	COG2873	o-acetylhomoserine
C2U64_RS02850	COG0488	(ABC) transporter
C2U64_RS02935	COG0833	amino acid
C2U64_RS02980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U64_RS02985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U64_RS03000	COG2226	methyltransferase
C2U64_RS03050	COG0070	glutamate synthase
C2U64_RS03050	COG0067	glutamate synthase
C2U64_RS03050	COG0069	glutamate synthase activity
C2U64_RS03055	COG0493	'glutamate synthase
C2U64_RS03065	COG1704	LemA family
C2U64_RS03070	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U64_RS03080	COG4969	Belongs to the N-Me-Phe pilin family
C2U64_RS03090	COG3307	-O-antigen
C2U64_RS03115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U64_RS03130	COG0194	GDP metabolic process
C2U64_RS03180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U64_RS03190	COG0335	large ribosomal subunit rRNA binding
C2U64_RS03200	COG5380	lipid catabolic process
C2U64_RS03205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U64_RS03220	COG5006	permease, DMT superfamily
C2U64_RS03230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U64_RS03235	COG0277	FAD linked oxidase domain protein
C2U64_RS03245	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2U64_RS03250	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U64_RS03265	COG1289	transmembrane transporter activity
C2U64_RS03275	COG0628	permease
C2U64_RS03280	COG1192	Involved in chromosome partitioning
C2U64_RS03310	COG0833	amino acid
C2U64_RS03315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U64_RS03320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U64_RS03330	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS03370	COG0583	DNA-binding transcription factor activity
C2U64_RS03395	COG0752	glycyl-tRNA synthetase alpha subunit
C2U64_RS03420	COG0517	IMP dehydrogenase activity
C2U64_RS03420	COG0617	tRNA 3'-terminal CCA addition
C2U64_RS03420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2U64_RS03425	COG1983	PspC domain protein
C2U64_RS03435	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS03450	COG0408	coproporphyrinogen oxidase activity
C2U64_RS03470	COG0513	Belongs to the DEAD box helicase family
C2U64_RS03480	COG1127	ABC transporter
C2U64_RS03485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U64_RS03495	COG2854	intermembrane phospholipid transfer
C2U64_RS03505	COG0598	Magnesium transport protein CorA
C2U64_RS03515	COG0494	nUDIX hydrolase
C2U64_RS03520	COG1040	competence protein
C2U64_RS03525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U64_RS03540	COG2937	Belongs to the GPAT DAPAT family
C2U64_RS03545	COG1946	Acyl-CoA thioesterase
C2U64_RS03550	COG1301	dicarboxylic acid transport
C2U64_RS03565	COG1959	2 iron, 2 sulfur cluster binding
C2U64_RS03570	COG1017	nitric oxide dioxygenase activity
C2U64_RS03570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_RS03580	COG0433	COG0433 Predicted ATPase
C2U64_RS03585	COG0626	cystathionine gamma-synthase activity
C2U64_RS03600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U64_RS03605	COG0088	Forms part of the polypeptide exit tunnel
C2U64_RS03740	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS03745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U64_RS03775	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U64_RS03780	COG0339	signal peptide processing
C2U64_RS03785	COG0557	exoribonuclease II activity
C2U64_RS03835	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U64_RS03840	COG1295	ribonuclease BN
C2U64_RS03875	COG1702	phosphate starvation-inducible protein PhoH
C2U64_RS03885	COG0739	heme binding
C2U64_RS03885	COG0741	lytic transglycosylase activity
C2U64_RS03885	COG1196	nuclear chromosome segregation
C2U64_RS03915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U64_RS03920	COG1183	phosphatidylcholine synthase activity
C2U64_RS03965	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS03970	COG1309	transcriptional regulator
C2U64_RS03985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U64_RS03990	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS04030	COG2969	positive regulation of protein catabolic process
C2U64_RS04035	COG0625	glutathione transferase activity
C2U64_RS04040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U64_RS04045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U64_RS04050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U64_RS04055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U64_RS04060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U64_RS04080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U64_RS04090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U64_RS04095	COG1408	metallophosphoesterase
C2U64_RS04100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U64_RS04100	COG2885	chlorophyll binding
C2U64_RS04105	COG2199	diguanylate cyclase activity
C2U64_RS04175	COG1607	acyl-coa hydrolase
C2U64_RS04210	COG2350	Protein conserved in bacteria
C2U64_RS04225	COG3781	membrane
C2U64_RS04235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U64_RS04250	COG1862	Preprotein translocase
C2U64_RS04285	COG2205	protein histidine kinase activity
C2U64_RS04285	COG2198	Histidine kinase
C2U64_RS04285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_RS04285	COG0784	Response regulator, receiver
C2U64_RS04290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U64_RS04305	COG0726	polysaccharide deacetylase
C2U64_RS04320	COG1216	Glycosyl transferase, family 2
C2U64_RS04370	COG0625	glutathione transferase activity
C2U64_RS04375	COG0583	DNA-binding transcription factor activity
C2U64_RS04380	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS04385	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS04395	COG2205	protein histidine kinase activity
C2U64_RS04400	COG0745	RESPONSE REGULATOR receiver
C2U64_RS04410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U64_RS04430	COG2096	Adenosyltransferase
C2U64_RS04435	COG4206	TonB-dependent receptor
C2U64_RS04480	COG0285	dihydrofolate synthase activity
C2U64_RS04500	COG0450	alkyl hydroperoxide reductase
C2U64_RS04515	COG0477	Major facilitator Superfamily
C2U64_RS04520	COG1272	protein, Hemolysin III
C2U64_RS04530	COG2153	protein acetylation
C2U64_RS04550	COG0183	Belongs to the thiolase family
C2U64_RS04555	COG2207	Transcriptional regulator
C2U64_RS04575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_RS04595	COG0183	Belongs to the thiolase family
C2U64_RS04605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U64_RS04605	COG2885	chlorophyll binding
C2U64_RS04610	COG1690	Belongs to the RtcB family
C2U64_RS04615	COG0833	amino acid
C2U64_RS04625	COG2233	PERMEase
C2U64_RS04630	COG1217	gtp-binding protein TYPA
C2U64_RS04655	COG2094	Belongs to the DNA glycosylase MPG family
C2U64_RS04660	COG4772	TonB-dependent receptor
C2U64_RS04665	COG1902	pentaerythritol trinitrate reductase activity
C2U64_RS04680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U64_RS04685	COG0354	folic acid binding
C2U64_RS04705	COG2233	PERMEase
C2U64_RS04710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_RS04715	COG0251	oxidation-reduction process
C2U64_RS04720	COG1335	isochorismatase
C2U64_RS04725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_RS04730	COG0778	Nitroreductase
C2U64_RS04735	COG0596	Alpha beta hydrolase
C2U64_RS04740	COG3189	MarR family transcriptional regulator
C2U64_RS04745	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U64_RS04750	COG3422	double-strand break repair
C2U64_RS04790	COG0840	transmembrane signaling receptor activity
C2U64_RS04810	COG5510	response to toxic substance
C2U64_RS04820	COG2832	Protein of unknown function (DUF454)
C2U64_RS04825	COG1376	ErfK ybiS ycfS ynhG family protein
C2U64_RS04865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U64_RS04875	COG1289	transmembrane transporter activity
C2U64_RS04880	COG2814	Major facilitator Superfamily
C2U64_RS04905	COG1115	amino acid carrier protein
C2U64_RS04910	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U64_RS04915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U64_RS04920	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2U64_RS04925	COG3590	peptidase
C2U64_RS04950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U64_RS04960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U64_RS04965	COG1077	Cell shape determining protein MreB Mrl
C2U64_RS04970	COG1792	Involved in formation and maintenance of cell shape
C2U64_RS04975	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U64_RS04980	COG0424	maF-like protein
C2U64_RS04985	COG1530	ribonuclease E activity
C2U64_RS04995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U64_RS05015	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U64_RS05040	COG2207	Transcriptional regulator
C2U64_RS05070	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U64_RS05080	COG1113	amino acid transport
C2U64_RS05085	COG2828	Protein conserved in bacteria
C2U64_RS05090	COG0142	geranyltranstransferase activity
C2U64_RS05095	COG2315	Protein conserved in bacteria
C2U64_RS05110	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U64_RS05135	COG2194	sulfuric ester hydrolase activity
C2U64_RS05140	COG0745	RESPONSE REGULATOR receiver
C2U64_RS05145	COG0642	Histidine kinase
C2U64_RS05160	COG0004	ammonium transporteR
C2U64_RS05165	COG0583	DNA-binding transcription factor activity
C2U64_RS05190	COG0525	valine-tRNA ligase activity
C2U64_RS05200	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS05210	COG0393	Putative heavy-metal-binding
C2U64_RS05215	COG0393	Putative heavy-metal-binding
C2U64_RS05220	COG1538	Outer membrane efflux protein
C2U64_RS05230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_RS05235	COG0671	phosphoesterase, PA-phosphatase related
C2U64_RS05260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U64_RS05275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U64_RS05275	COG1648	precorrin-2 dehydrogenase activity
C2U64_RS05280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U64_RS05300	COG0531	amino acid
C2U64_RS05315	COG0321	lipoyl(octanoyl) transferase activity
C2U64_RS05320	COG2921	Belongs to the UPF0250 family
C2U64_RS05365	COG2009	succinate dehydrogenase
C2U64_RS05370	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U64_RS05375	COG1053	succinate dehydrogenase
C2U64_RS05380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U64_RS05405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U64_RS05425	COG2354	Protein conserved in bacteria
C2U64_RS05430	COG2321	neutral zinc metallopeptidase
C2U64_RS05465	COG2843	Capsule synthesis protein
C2U64_RS05490	COG0589	response to stress
C2U64_RS05500	COG0251	oxidation-reduction process
C2U64_RS05505	COG1309	transcriptional regulator
C2U64_RS05520	COG0505	Belongs to the CarA family
C2U64_RS05555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U64_RS05560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U64_RS05605	COG2264	protein methyltransferase activity
C2U64_RS05615	COG0477	Major facilitator Superfamily
C2U64_RS05620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U64_RS05635	COG1597	lipid kinase activity
C2U64_RS05640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U64_RS05970	COG0582	viral genome integration into host DNA
C2U64_RS05980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U64_RS05985	COG0584	glycerophosphoryl diester phosphodiesterase
C2U64_RS06005	COG0741	lytic transglycosylase activity
C2U64_RS06030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U64_RS06075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_RS06080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_RS06085	COG0778	Nitroreductase
C2U64_RS06100	COG1929	Belongs to the glycerate kinase type-1 family
C2U64_RS06105	COG0243	molybdopterin cofactor binding
C2U64_RS06110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U64_RS06145	COG1115	amino acid carrier protein
C2U64_RS06150	COG1113	amino acid transport
C2U64_RS06160	COG0019	diaminopimelate decarboxylase activity
C2U64_RS06170	COG1280	lysine exporter protein (LysE YggA)
C2U64_RS06175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U64_RS06205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_RS06235	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U64_RS06240	COG1136	(ABC) transporter
C2U64_RS06245	COG0658	competence protein
C2U64_RS06245	COG2333	competence protein COMEC
C2U64_RS06255	COG0616	signal peptide processing
C2U64_RS06255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U64_RS06260	COG0596	Alpha beta hydrolase
C2U64_RS06265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U64_RS06275	COG0628	permease
C2U64_RS06315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U64_RS06335	COG0823	Involved in the tonB-independent uptake of proteins
C2U64_RS06355	COG0824	Thioesterase
C2U64_RS06360	COG1473	amidohydrolase
C2U64_RS06380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U64_RS06380	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U64_RS06385	COG2814	Major facilitator Superfamily
C2U64_RS06390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U64_RS06395	COG1024	Enoyl-CoA hydratase
C2U64_RS06400	COG1051	belongs to the nudix hydrolase family
C2U64_RS06400	COG1056	cytidyltransferase-related domain
C2U64_RS06415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U64_RS06430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U64_RS06445	COG4625	pathogenesis
C2U64_RS06450	COG0583	DNA-binding transcription factor activity
C2U64_RS06455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U64_RS06460	COG4208	sulfate ABC transporter
C2U64_RS06465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U64_RS06475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U64_RS06480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U64_RS06485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U64_RS06505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U64_RS06515	COG0481	GTPase activity
C2U64_RS06520	COG0681	Belongs to the peptidase S26 family
C2U64_RS06530	COG0571	ribonuclease III activity
C2U64_RS06535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2U64_RS06550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U64_RS06560	COG4221	oxidoreductase activity
C2U64_RS06590	COG0436	Aminotransferase
C2U64_RS06610	COG0556	nucleotide-excision repair
C2U64_RS06620	COG2962	Rard protein
C2U64_RS06665	COG2070	2-Nitropropane dioxygenase
C2U64_RS06680	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U64_RS06695	COG1215	transferase activity, transferring glycosyl groups
C2U64_RS06710	COG0415	Belongs to the DNA photolyase family
C2U64_RS06720	COG1252	NADH dehydrogenase
C2U64_RS06725	COG1686	Belongs to the peptidase S11 family
C2U64_RS06740	COG1187	pseudouridine synthase activity
C2U64_RS06755	COG0477	Major facilitator Superfamily
C2U64_RS06760	COG0583	DNA-binding transcription factor activity
C2U64_RS06765	COG1823	symporter activity
C2U64_RS06775	COG0612	Peptidase, M16
C2U64_RS06800	COG0352	thiamine-phosphate diphosphorylase activity
C2U64_RS06835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_RS06850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U64_RS06855	COG0076	glutamate decarboxylase activity
C2U64_RS06865	COG1522	sequence-specific DNA binding
C2U64_RS06870	COG3961	Belongs to the TPP enzyme family
C2U64_RS06875	COG1113	amino acid transport
C2U64_RS06880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2U64_RS06885	COG0573	inorganic phosphate transmembrane transporter activity
C2U64_RS06895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U64_RS06900	COG0616	signal peptide processing
C2U64_RS06935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U64_RS06940	COG1686	Belongs to the peptidase S11 family
C2U64_RS06965	COG0583	DNA-binding transcription factor activity
C2U64_RS06970	COG1067	ATP-dependent peptidase activity
C2U64_RS07010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U64_RS07015	COG1966	Carbon starvation protein
C2U64_RS07020	COG2879	small protein
C2U64_RS07070	COG1741	Belongs to the pirin family
C2U64_RS07085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U64_RS07090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U64_RS07095	COG4605	iron ion homeostasis
C2U64_RS07100	COG4604	ABC transporter, ATP-binding protein
C2U64_RS07105	COG4607	ABC-type enterochelin transport system periplasmic component
C2U64_RS07110	COG4774	siderophore transport
C2U64_RS07120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U64_RS07125	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U64_RS07130	COG1535	isochorismatase
C2U64_RS07130	COG3433	isochorismatase activity
C2U64_RS07145	COG1132	(ABC) transporter
C2U64_RS07150	COG1132	(ABC) transporter
C2U64_RS07155	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2U64_RS07160	COG2977	Belongs to the P-Pant transferase superfamily
C2U64_RS07165	COG1169	isochorismate synthase
C2U64_RS07185	COG3739	integral membrane protein
C2U64_RS07205	COG0302	gtp cyclohydrolase
C2U64_RS07215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2U64_RS07225	COG2840	Smr protein MutS2
C2U64_RS07260	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U64_RS07390	COG5410	chromosome segregation
C2U64_RS07500	COG0582	viral genome integration into host DNA
C2U64_RS07515	COG0174	glutamine synthetase
C2U64_RS07525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U64_RS07560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U64_RS07565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U64_RS07570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U64_RS07590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U64_RS07595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2U64_RS07600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U64_RS07615	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS07620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U64_RS07625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U64_RS07635	COG2223	nitrite transmembrane transporter activity
C2U64_RS07645	COG0024	Methionine aminopeptidase
C2U64_RS07650	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U64_RS07690	COG2951	lytic endotransglycosylase activity
C2U64_RS07695	COG0772	Belongs to the SEDS family
C2U64_RS07710	COG0842	Transport permease protein
C2U64_RS07715	COG1131	(ABC) transporter
C2U64_RS07760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_RS07770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_RS07775	COG4215	(ABC) transporter
C2U64_RS07780	COG4160	amino acid transport
C2U64_RS07785	COG4598	ABC transporter
C2U64_RS07795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U64_RS07800	COG0826	peptidase U32
C2U64_RS07805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_RS07810	COG0384	phenazine biosynthesis protein PhzF
C2U64_RS07820	COG1720	tRNA m6t6A37 methyltransferase activity
C2U64_RS07830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U64_RS07845	COG0642	Histidine kinase
C2U64_RS07855	COG0494	nUDIX hydrolase
C2U64_RS07865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U64_RS07870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U64_RS07875	COG3139	Protein of unknown function (DUF1315)
C2U64_RS07880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U64_RS07890	COG1301	dicarboxylic acid transport
C2U64_RS07895	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS07910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U64_RS07920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U64_RS07925	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U64_RS07945	COG1690	Belongs to the RtcB family
C2U64_RS07950	COG1234	tRNA 3'-trailer cleavage
C2U64_RS07955	COG4650	regulator
C2U64_RS07985	COG2363	Small membrane protein
C2U64_RS08005	COG0513	Belongs to the DEAD box helicase family
C2U64_RS08015	COG0778	Nitroreductase
C2U64_RS08045	COG1286	toxin biosynthetic process
C2U64_RS08070	COG4783	chaperone-mediated protein folding
C2U64_RS08075	COG1610	YqeY-like protein
C2U64_RS08130	COG1278	Cold shock
C2U64_RS08145	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U64_RS08150	COG0786	glutamate:sodium symporter activity
C2U64_RS08155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U64_RS08155	COG0475	glutathione-regulated potassium exporter activity
C2U64_RS08160	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS08210	COG1309	transcriptional regulator
C2U64_RS08220	COG2985	domain, Protein
C2U64_RS08235	COG2995	paraquat-inducible protein a
C2U64_RS08240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U64_RS08240	COG3008	intermembrane lipid transfer
C2U64_RS08250	COG2351	hydroxyisourate hydrolase activity
C2U64_RS08290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U64_RS08300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U64_RS08305	COG0642	Histidine kinase
C2U64_RS08310	COG0745	RESPONSE REGULATOR receiver
C2U64_RS08325	COG1794	racemase activity, acting on amino acids and derivatives
C2U64_RS08355	COG1301	dicarboxylic acid transport
C2U64_RS08365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U64_RS08370	COG2011	ABC-type metal ion transport system permease component
C2U64_RS08375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U64_RS08385	COG0151	Belongs to the GarS family
C2U64_RS08395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U64_RS08425	COG2308	Evidence 4 Homologs of previously reported genes of
C2U64_RS08435	COG1305	Transglutaminase-like
C2U64_RS08445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U64_RS08450	COG0305	Participates in initiation and elongation during chromosome replication
C2U64_RS08475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U64_RS08480	COG1845	cytochrome c oxidase, subunit III
C2U64_RS08485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U64_RS08515	COG3328	transposase activity
C2U64_RS08520	COG1649	PFAM Uncharacterised BCR, COG1649
C2U64_RS08520	COG0726	polysaccharide deacetylase
C2U64_RS08525	COG1215	transferase activity, transferring glycosyl groups
C2U64_RS08530	COG3658	cytochrome
C2U64_RS08540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_RS08555	COG0583	DNA-binding transcription factor activity
C2U64_RS08570	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U64_RS08575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_RS08580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_RS08595	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS08600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_RS08615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U64_RS08625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C2U64_RS08630	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2U64_RS08640	COG2205	protein histidine kinase activity
C2U64_RS08645	COG0745	RESPONSE REGULATOR receiver
C2U64_RS08650	COG0174	glutamine synthetase
C2U64_RS08670	COG0729	surface antigen
C2U64_RS08705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U64_RS08710	COG2814	Major facilitator Superfamily
C2U64_RS08765	COG2369	cell adhesion
C2U64_RS08770	COG4383	Mu-like prophage protein gp29
C2U64_RS08780	COG4373	Mu-like prophage FluMu protein gp28
C2U64_RS08845	COG3267	Type II secretory pathway component ExeA
C2U64_RS08845	COG3409	Peptidoglycan-binding domain 1 protein
C2U64_RS08920	COG0583	DNA-binding transcription factor activity
C2U64_RS08935	COG1187	pseudouridine synthase activity
C2U64_RS08955	COG0802	atpase or kinase
C2U64_RS08960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U64_RS08970	COG1923	regulation of RNA biosynthetic process
C2U64_RS08975	COG0697	spore germination
C2U64_RS09000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U64_RS09005	COG0519	Catalyzes the synthesis of GMP from XMP
C2U64_RS09005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U64_RS09015	COG4302	ethanolamine ammonia-lyase activity
C2U64_RS09020	COG4303	Ethanolamine ammonia lyase large subunit
C2U64_RS09025	COG0531	amino acid
C2U64_RS09045	COG1454	alcohol dehydrogenase
C2U64_RS09050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U64_RS09075	COG0308	aminopeptidase N
C2U64_RS09115	COG1605	Chorismate mutase
C2U64_RS09140	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS09175	COG3772	lysozyme
C2U64_RS09185	COG1733	regulation of RNA biosynthetic process
C2U64_RS09210	COG0583	DNA-binding transcription factor activity
C2U64_RS09250	COG0488	(ABC) transporter
C2U64_RS09255	COG0589	response to stress
C2U64_RS09275	COG3135	benzoate transporter
C2U64_RS09280	COG1522	sequence-specific DNA binding
C2U64_RS09290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U64_RS09295	COG0583	DNA-binding transcription factor activity
C2U64_RS09305	COG0183	Belongs to the thiolase family
C2U64_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS09315	COG2030	dehydratase
C2U64_RS09320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2U64_RS09345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U64_RS09355	COG0824	Thioesterase
C2U64_RS09360	COG1454	alcohol dehydrogenase
C2U64_RS09375	COG1335	isochorismatase
C2U64_RS09395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2U64_RS09425	COG0069	glutamate synthase activity
C2U64_RS09450	COG2814	Major facilitator Superfamily
C2U64_RS09465	COG0511	ligase activity, forming carbon-carbon bonds
C2U64_RS09490	COG4264	IucA IucC family
C2U64_RS09500	COG4264	IucA IucC family
C2U64_RS09505	COG2423	ornithine cyclodeaminase activity
C2U64_RS09510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U64_RS09515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_RS09515	COG1116	anion transmembrane transporter activity
C2U64_RS09530	COG2146	nitrite reductase [NAD(P)H] activity
C2U64_RS09530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_RS09535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_RS09540	COG0243	molybdopterin cofactor binding
C2U64_RS09550	COG0243	molybdopterin cofactor binding
C2U64_RS09555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U64_RS09570	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U64_RS09570	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U64_RS09575	COG0303	'Molybdopterin
C2U64_RS09585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_RS09590	COG0697	spore germination
C2U64_RS09615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U64_RS09685	COG2204	response regulator
C2U64_RS09690	COG3852	Histidine kinase
C2U64_RS09715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U64_RS09720	COG0575	Belongs to the CDS family
C2U64_RS09755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U64_RS09770	COG2137	regulation of response to DNA damage stimulus
C2U64_RS09780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2U64_RS09785	COG1011	Hydrolase
C2U64_RS09800	COG1522	sequence-specific DNA binding
C2U64_RS09810	COG1113	amino acid transport
C2U64_RS09815	COG0657	acetylesterase activity
C2U64_RS09830	COG0659	secondary active sulfate transmembrane transporter activity
C2U64_RS09865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U64_RS09865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U64_RS09865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U64_RS09870	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U64_RS09875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U64_RS09875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U64_RS09895	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C2U64_RS09905	COG0024	Methionine aminopeptidase
C2U64_RS09910	COG0583	DNA-binding transcription factor activity
C2U64_RS09920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U64_RS09925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U64_RS09930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U64_RS09930	COG0517	IMP dehydrogenase activity
C2U64_RS09955	COG0552	protein localization to endoplasmic reticulum
C2U64_RS09980	COG4890	Cyd operon protein YbgT
C2U64_RS09985	COG1294	oxidase, subunit
C2U64_RS10000	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U64_RS10010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U64_RS10025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U64_RS10030	COG0569	domain protein
C2U64_RS10035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U64_RS10065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U64_RS10070	COG0542	response to heat
C2U64_RS10080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U64_RS10095	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_RS10095	COG1902	pentaerythritol trinitrate reductase activity
C2U64_RS10135	COG0148	phosphopyruvate hydratase activity
C2U64_RS10140	COG2323	membrane
C2U64_RS10150	COG4773	Receptor
C2U64_RS10155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U64_RS10165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U64_RS10170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U64_RS10175	COG0183	Belongs to the thiolase family
C2U64_RS10180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U64_RS10185	COG0596	Alpha beta hydrolase
C2U64_RS10190	COG2271	Major facilitator Superfamily
C2U64_RS10195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U64_RS10200	COG3485	protocatechuate 3,4-dioxygenase
C2U64_RS10205	COG3485	protocatechuate 3,4-dioxygenase
C2U64_RS10210	COG0710	3-dehydroquinate dehydratase activity
C2U64_RS10215	COG3420	alginic acid biosynthetic process
C2U64_RS10220	COG3659	wide pore channel activity
C2U64_RS10225	COG4993	Dehydrogenase
C2U64_RS10235	COG2391	methyltransferase activity
C2U64_RS10250	COG1414	Transcriptional regulator
C2U64_RS10255	COG0583	DNA-binding transcription factor activity
C2U64_RS10260	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS10285	COG2814	Major facilitator Superfamily
C2U64_RS10295	COG0154	amidase activity
C2U64_RS10315	COG4638	Rieske (2fe-2S)
C2U64_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS10335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_RS10345	COG3733	amine oxidase
C2U64_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS10360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U64_RS10365	COG0183	Belongs to the thiolase family
C2U64_RS10370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U64_RS10375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U64_RS10385	COG4829	muconolactone delta-isomerase
C2U64_RS10390	COG4948	Mandelate Racemase Muconate Lactonizing
C2U64_RS10395	COG0583	DNA-binding transcription factor activity
C2U64_RS10405	COG2186	Transcriptional regulator
C2U64_RS10425	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS10430	COG2351	hydroxyisourate hydrolase activity
C2U64_RS10435	COG2233	PERMEase
C2U64_RS10445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_RS10450	COG2186	Transcriptional regulator
C2U64_RS10465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_RS10475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_RS10495	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_RS10495	COG1902	pentaerythritol trinitrate reductase activity
C2U64_RS10535	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS10545	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_RS10560	COG1309	transcriptional regulator
C2U64_RS10620	COG0583	DNA-binding transcription factor activity
C2U64_RS10645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U64_RS10650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U64_RS10665	COG2831	hemolysin activation secretion protein
C2U64_RS10730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U64_RS10735	COG1120	ATPase activity
C2U64_RS10745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U64_RS10795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U64_RS10830	COG4628	conserved protein (DUF2132)
C2U64_RS10845	COG3539	Fimbrial protein
C2U64_RS10870	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C2U64_RS10880	COG0753	catalase activity
C2U64_RS10900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U64_RS10910	COG2205	protein histidine kinase activity
C2U64_RS10915	COG0745	RESPONSE REGULATOR receiver
C2U64_RS10920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_RS10925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_RS10980	COG1535	isochorismatase
C2U64_RS10980	COG3433	isochorismatase activity
C2U64_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS10990	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U64_RS10995	COG4149	molybdate abc transporter
C2U64_RS11000	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2U64_RS11010	COG4638	Rieske (2fe-2S)
C2U64_RS11015	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U64_RS11020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_RS11020	COG0543	2 iron, 2 sulfur cluster binding
C2U64_RS11035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_RS11045	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS11065	COG2207	Transcriptional regulator
C2U64_RS11070	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS11075	COG2610	gluconate transmembrane transporter activity
C2U64_RS11115	COG0583	DNA-binding transcription factor activity
C2U64_RS11130	COG2031	fatty acid transporter
C2U64_RS11135	COG0183	Belongs to the thiolase family
C2U64_RS11140	COG0583	DNA-binding transcription factor activity
C2U64_RS11145	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS11150	COG0583	DNA-binding transcription factor activity
C2U64_RS11165	COG1027	Aspartate ammonia-lyase
C2U64_RS11175	COG0477	Major facilitator Superfamily
C2U64_RS11185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U64_RS11190	COG1733	regulation of RNA biosynthetic process
C2U64_RS11195	COG2207	Transcriptional regulator
C2U64_RS11195	COG3708	Transcriptional regulator
C2U64_RS11210	COG0730	response to heat
C2U64_RS11230	COG3781	membrane
C2U64_RS11235	COG1063	alcohol dehydrogenase
C2U64_RS11245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U64_RS11250	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U64_RS11255	COG0022	dehydrogenase e1 component
C2U64_RS11260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2U64_RS11265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U64_RS11280	COG3706	GGDEF domain
C2U64_RS11300	COG0133	tryptophan synthase activity
C2U64_RS11310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U64_RS11340	COG0583	DNA-binding transcription factor activity
C2U64_RS11345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U64_RS11355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U64_RS11415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U64_RS11420	COG4773	Receptor
C2U64_RS11445	COG0730	response to heat
C2U64_RS11450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U64_RS11470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C2U64_RS11500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U64_RS11515	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS11520	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS11525	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_RS11530	COG2207	Transcriptional regulator
C2U64_RS11535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U64_RS11540	COG0776	regulation of translation
C2U64_RS11565	COG0822	iron-sulfur transferase activity
C2U64_RS11570	COG0316	Belongs to the HesB IscA family
C2U64_RS11600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U64_RS11620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U64_RS11625	COG0702	epimerase
C2U64_RS11665	COG0601	transmembrane transport
C2U64_RS11670	COG0339	signal peptide processing
C2U64_RS11675	COG4166	transmembrane transport
C2U64_RS11720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U64_RS11830	COG3328	transposase activity
C2U64_RS11840	COG5484	DNA packaging
C2U64_RS11840	COG3728	DNA packaging
C2U64_RS11925	COG5377	YqaJ viral recombinase family
C2U64_RS11935	COG0210	DNA helicase
C2U64_RS11965	COG0582	viral genome integration into host DNA
C2U64_RS11970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U64_RS11985	COG3328	transposase activity
C2U64_RS11990	COG2431	L-lysine efflux transmembrane transporter activity
C2U64_RS12005	COG0776	regulation of translation
C2U64_RS12070	COG0084	hydrolase, TatD family'
C2U64_RS12090	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U64_RS12095	COG1132	(ABC) transporter
C2U64_RS12105	COG0811	peptide transport
C2U64_RS12110	COG1475	DNA binding
C2U64_RS12115	COG1192	Involved in chromosome partitioning
C2U64_RS12125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U64_RS12130	COG3178	'Phosphotransferase
C2U64_RS12140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U64_RS12165	COG0424	maF-like protein
C2U64_RS12170	COG2850	peptidyl-arginine hydroxylation
C2U64_RS12180	COG0640	Transcriptional regulator
C2U64_RS12190	COG3619	membrane
C2U64_RS12195	COG3122	Protein conserved in bacteria
C2U64_RS12200	COG1132	(ABC) transporter
C2U64_RS12220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U64_RS12225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U64_RS12235	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U64_RS12235	COG0506	proline dehydrogenase activity
C2U64_RS12235	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U64_RS12240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2U64_RS12255	COG3698	Phosphodiester glycosidase
C2U64_RS12265	COG2353	YceI-like domain
C2U64_RS12275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U64_RS12320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U64_RS12320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U64_RS12350	COG3539	Fimbrial protein
C2U64_RS12385	COG0583	DNA-binding transcription factor activity
C2U64_RS12390	COG0697	spore germination
C2U64_RS12400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U64_RS12410	COG0583	DNA-binding transcription factor activity
C2U64_RS12425	COG1309	transcriptional regulator
C2U64_RS12440	COG1522	sequence-specific DNA binding
C2U64_RS12450	COG1126	abc transporter atp-binding protein
C2U64_RS12455	COG0765	amino acid transport
C2U64_RS12460	COG0765	amino acid transport
C2U64_RS12490	COG1464	Belongs to the NlpA lipoprotein family
C2U64_RS12500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U64_RS12505	COG2011	ABC-type metal ion transport system permease component
C2U64_RS12510	COG0012	GTP binding
C2U64_RS12535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2U64_RS12570	COG2207	Transcriptional regulator
C2U64_RS12570	COG1917	Cupin 2, conserved barrel domain protein
C2U64_RS12575	COG0386	Belongs to the glutathione peroxidase family
C2U64_RS12585	COG0436	Aminotransferase
C2U64_RS12590	COG1301	dicarboxylic acid transport
C2U64_RS12625	COG3634	alkyl hydroperoxide reductase activity
C2U64_RS12640	COG0583	DNA-binding transcription factor activity
C2U64_RS12645	COG0431	NADPH-dependent FMN reductase
C2U64_RS12650	COG0798	PFAM Bile acid sodium symporter
C2U64_RS12660	COG0640	Transcriptional regulator
C2U64_RS12675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2U64_RS12685	COG0583	DNA-binding transcription factor activity
C2U64_RS12695	COG1953	Uracil, thiamine, allantoin
C2U64_RS12705	COG2175	clavaminate synthase activity
C2U64_RS12710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_RS12715	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U64_RS12720	COG4521	taurine ABC transporter
C2U64_RS12730	COG0477	Major facilitator Superfamily
C2U64_RS12750	COG1271	oxidase subunit
C2U64_RS12755	COG1294	oxidase, subunit
C2U64_RS12765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_RS12785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2U64_RS12805	COG3052	prosthetic group binding
C2U64_RS12810	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C2U64_RS12835	COG1346	cytolysis
C2U64_RS12845	COG0583	DNA-binding transcription factor activity
C2U64_RS12850	COG0625	glutathione transferase activity
C2U64_RS12855	COG0625	glutathione transferase activity
C2U64_RS12875	COG0583	DNA-binding transcription factor activity
C2U64_RS12890	COG1045	serine acetyltransferase
C2U64_RS12900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U64_RS12905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U64_RS12910	COG1280	lysine exporter protein (LysE YggA)
C2U64_RS12925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_RS12930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U64_RS12940	COG0765	amino acid transport
C2U64_RS12945	COG0765	amino acid transport
C2U64_RS12965	COG0784	Response regulator, receiver
C2U64_RS12965	COG2205	protein histidine kinase activity
C2U64_RS12985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U64_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS13055	COG0583	DNA-binding transcription factor activity
C2U64_RS13070	COG2814	Major facilitator Superfamily
C2U64_RS13085	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_RS13090	COG1309	transcriptional regulator
C2U64_RS13095	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS13100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U64_RS13105	COG1024	Enoyl-CoA hydratase
C2U64_RS13110	COG4770	biotin carboxylase activity
C2U64_RS13120	COG0583	DNA-binding transcription factor activity
C2U64_RS13135	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS13145	COG2814	Major facilitator Superfamily
C2U64_RS13155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U64_RS13160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U64_RS13165	COG2814	Major facilitator Superfamily
C2U64_RS13170	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS13175	COG1024	Enoyl-CoA hydratase
C2U64_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS13185	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U64_RS13190	COG0183	Belongs to the thiolase family
C2U64_RS13200	COG2814	Major facilitator Superfamily
C2U64_RS13210	COG1024	Enoyl-CoA hydratase
C2U64_RS13225	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS13230	COG2814	Major facilitator Superfamily
C2U64_RS13235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U64_RS13240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2U64_RS13255	COG3842	ATPase activity
C2U64_RS13260	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U64_RS13275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_RS13280	COG1414	Transcriptional regulator
C2U64_RS13290	COG0583	DNA-binding transcription factor activity
C2U64_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS13325	COG0583	DNA-binding transcription factor activity
C2U64_RS13330	COG2050	protein possibly involved in aromatic compounds catabolism
C2U64_RS13340	COG3327	negative regulation of DNA-templated transcription, initiation
C2U64_RS13345	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2U64_RS13350	COG0183	Belongs to the thiolase family
C2U64_RS13355	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U64_RS13360	COG1024	Enoyl-CoA hydratase
C2U64_RS13365	COG1024	Enoyl-CoA hydratase
C2U64_RS13370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_RS13375	COG2151	metal-sulfur cluster biosynthetic enzyme
C2U64_RS13380	COG3396	Phenylacetate-CoA oxygenase
C2U64_RS13385	COG3460	Phenylacetate-CoA oxygenase
C2U64_RS13390	COG3396	Phenylacetate-CoA oxygenase
C2U64_RS13395	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS13395	COG2030	dehydratase
C2U64_RS13400	COG1760	l-serine dehydratase
C2U64_RS13420	COG0789	Transcriptional regulator
C2U64_RS13430	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2U64_RS13435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_RS13450	COG2807	transmembrane transport
C2U64_RS13455	COG0590	tRNA wobble adenosine to inosine editing
C2U64_RS13460	COG0666	response to abiotic stimulus
C2U64_RS13485	COG4770	biotin carboxylase activity
C2U64_RS13500	COG1063	alcohol dehydrogenase
C2U64_RS13505	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U64_RS13550	COG2831	hemolysin activation secretion protein
C2U64_RS13555	COG0038	chloride channel
C2U64_RS13560	COG4770	biotin carboxylase activity
C2U64_RS13580	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U64_RS13585	COG0583	DNA-binding transcription factor activity
C2U64_RS13595	COG1595	DNA-templated transcription, initiation
C2U64_RS13605	COG3220	belongs to the UPF0276 family
C2U64_RS13665	COG0702	epimerase
C2U64_RS13670	COG1733	regulation of RNA biosynthetic process
C2U64_RS13690	COG1051	belongs to the nudix hydrolase family
C2U64_RS13700	COG1595	DNA-templated transcription, initiation
C2U64_RS13705	COG3712	iron ion homeostasis
C2U64_RS13745	COG3038	cytochrome b561
C2U64_RS13750	COG0753	catalase activity
C2U64_RS13755	COG1733	regulation of RNA biosynthetic process
C2U64_RS13780	COG1522	sequence-specific DNA binding
C2U64_RS13785	COG0531	amino acid
C2U64_RS13790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U64_RS13805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U64_RS13820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U64_RS13830	COG4122	O-methyltransferase activity
C2U64_RS13860	COG1538	Outer membrane efflux protein
C2U64_RS13865	COG1137	ATPase activity
C2U64_RS13870	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U64_RS13880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U64_RS14015	COG5410	chromosome segregation
C2U64_RS14180	COG2814	Major facilitator Superfamily
C2U64_RS14190	COG0668	transmembrane transport
C2U64_RS14255	COG2226	methyltransferase
C2U64_RS14280	COG1278	Cold shock
C2U64_RS14285	COG1560	Kdo2-lipid A biosynthetic process
C2U64_RS14290	COG1280	lysine exporter protein (LysE YggA)
C2U64_RS14330	COG1570	exodeoxyribonuclease VII activity
C2U64_RS14415	COG2871	sodium ion transport
C2U64_RS14425	COG0583	DNA-binding transcription factor activity
C2U64_RS14435	COG4638	Rieske (2fe-2S)
C2U64_RS14440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U64_RS14445	COG0633	Ferredoxin
C2U64_RS14445	COG0543	2 iron, 2 sulfur cluster binding
C2U64_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS14455	COG3135	benzoate transporter
C2U64_RS14460	COG2814	Major facilitator Superfamily
C2U64_RS14475	COG1643	Atp-dependent helicase
C2U64_RS14500	COG3634	alkyl hydroperoxide reductase activity
C2U64_RS14520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U64_RS14525	COG0625	glutathione transferase activity
C2U64_RS14535	COG2885	chlorophyll binding
C2U64_RS14570	COG0542	response to heat
C2U64_RS14585	COG1765	OsmC-like protein
C2U64_RS14600	COG0667	Aldo Keto reductase
C2U64_RS14615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U64_RS14625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U64_RS14635	COG0582	viral genome integration into host DNA
C2U64_RS14655	COG3293	Transposase
C2U64_RS14660	COG1063	alcohol dehydrogenase
C2U64_RS14695	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C2U64_RS14700	COG3421	Type III restriction
C2U64_RS14735	COG0739	heme binding
C2U64_RS14735	COG0741	lytic transglycosylase activity
C2U64_RS14735	COG1196	nuclear chromosome segregation
C2U64_RS14750	COG1598	PFAM Uncharacterised protein family UPF0150
C2U64_RS14930	COG0527	aspartate kinase activity
C2U64_RS14940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U64_RS14950	COG3038	cytochrome b561
C2U64_RS14955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U64_RS14960	COG2252	PERMEase
C2U64_RS14970	COG1741	Belongs to the pirin family
C2U64_RS14975	COG1309	transcriptional regulator
C2U64_RS14990	COG2072	flavoprotein involved in K transport
C2U64_RS14995	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2U64_RS15000	COG0583	DNA-binding transcription factor activity
C2U64_RS15015	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U64_RS15045	COG1944	ATP diphosphatase activity
C2U64_RS15065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U64_RS15080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U64_RS15100	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C2U64_RS15105	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS15120	COG2814	Major facilitator Superfamily
C2U64_RS15125	COG1024	Enoyl-CoA hydratase
C2U64_RS15140	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS15165	COG2186	Transcriptional regulator
C2U64_RS15170	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS15180	COG4948	Mandelate Racemase Muconate Lactonizing
C2U64_RS15185	COG2271	Major facilitator Superfamily
C2U64_RS15190	COG2721	sulfolactate sulfo-lyase activity
C2U64_RS15195	COG0697	spore germination
C2U64_RS15215	COG1113	amino acid transport
C2U64_RS15235	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS15255	COG0531	amino acid
C2U64_RS15265	COG1113	amino acid transport
C2U64_RS15300	COG2801	Transposase and inactivated derivatives
C2U64_RS15310	COG4269	membrane
C2U64_RS15330	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_RS15330	COG1902	pentaerythritol trinitrate reductase activity
C2U64_RS15355	COG3328	transposase activity
C2U64_RS15370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U64_RS15395	COG4172	Belongs to the ABC transporter superfamily
C2U64_RS15400	COG4239	(ABC) transporter, permease
C2U64_RS15405	COG4174	ABC transporter (Permease)
C2U64_RS15410	COG4166	transmembrane transport
C2U64_RS15415	COG1388	LysM domain
C2U64_RS15415	COG0741	lytic transglycosylase activity
C2U64_RS15460	COG0583	DNA-binding transcription factor activity
C2U64_RS15465	COG1279	arginine transmembrane transporter activity
C2U64_RS15485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_RS15490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_RS15495	COG0006	proline dipeptidase activity
C2U64_RS15535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U64_RS15550	COG3384	dioxygenase
C2U64_RS15560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U64_RS15565	COG2878	Part of a membrane complex involved in electron transport
C2U64_RS15570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U64_RS15595	COG0768	penicillin binding
C2U64_RS15600	COG0742	ribosomal rna small subunit methyltransferase
C2U64_RS15615	COG0830	nickel cation binding
C2U64_RS15625	COG0804	urea catabolic process
C2U64_RS15650	COG3015	lipoprotein NlpE involved in copper resistance
C2U64_RS15665	COG1253	flavin adenine dinucleotide binding
C2U64_RS15670	COG2851	Citrate transporter
C2U64_RS15720	COG1773	rubredoxin
C2U64_RS15725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U64_RS15730	COG2267	carboxylic ester hydrolase activity
C2U64_RS15735	COG0583	DNA-binding transcription factor activity
C2U64_RS15765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U64_RS15770	COG4181	ATPase activity
C2U64_RS15815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U64_RS15835	COG0306	phosphate transporter
C2U64_RS15850	COG3958	Transketolase
C2U64_RS15855	COG3959	Transketolase, thiamine diphosphate binding domain
C2U64_RS15860	COG2271	Major facilitator Superfamily
C2U64_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS15870	COG0583	DNA-binding transcription factor activity
C2U64_RS15890	COG2223	nitrite transmembrane transporter activity
C2U64_RS15895	COG0662	Cupin 2, conserved barrel domain protein
C2U64_RS15895	COG2207	Transcriptional regulator
C2U64_RS15900	COG2066	Belongs to the glutaminase family
C2U64_RS15905	COG0242	peptide deformylase activity
C2U64_RS15910	COG0477	Major facilitator Superfamily
C2U64_RS15920	COG0028	Belongs to the TPP enzyme family
C2U64_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS15940	COG2267	carboxylic ester hydrolase activity
C2U64_RS15950	COG2271	Major facilitator Superfamily
C2U64_RS15955	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U64_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS15985	COG1414	Transcriptional regulator
C2U64_RS16000	COG1024	Enoyl-CoA hydratase
C2U64_RS16010	COG1215	transferase activity, transferring glycosyl groups
C2U64_RS16015	COG1649	PFAM Uncharacterised BCR, COG1649
C2U64_RS16015	COG0726	polysaccharide deacetylase
C2U64_RS16025	COG4681	YaeQ
C2U64_RS16035	COG0523	cobalamin synthesis protein
C2U64_RS16045	COG1607	acyl-coa hydrolase
C2U64_RS16055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U64_RS16060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U64_RS16065	COG1309	transcriptional regulator
C2U64_RS16090	COG2040	homocysteine
C2U64_RS16095	COG0531	amino acid
C2U64_RS16120	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS16150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U64_RS16155	COG0477	Major facilitator Superfamily
C2U64_RS16185	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS16215	COG1401	restriction endodeoxyribonuclease activity
C2U64_RS16235	COG0405	Gamma-glutamyltransferase
C2U64_RS16240	COG2814	Major facilitator Superfamily
C2U64_RS16250	COG2050	protein possibly involved in aromatic compounds catabolism
C2U64_RS16265	COG1090	epimerase
C2U64_RS16285	COG0420	3'-5' exonuclease activity
C2U64_RS16310	COG0735	belongs to the Fur family
C2U64_RS16315	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U64_RS16320	COG2914	Belongs to the UPF0125 (RnfH) family
C2U64_RS16340	COG0121	glutamine amidotransferase
C2U64_RS16355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U64_RS16365	COG0210	DNA helicase
C2U64_RS16370	COG2885	chlorophyll binding
C2U64_RS16375	COG0204	Acyl-transferase
C2U64_RS16390	COG2894	cell division
C2U64_RS16405	COG1280	lysine exporter protein (LysE YggA)
C2U64_RS16410	COG1674	ftsk spoiiie
C2U64_RS16415	COG0492	ferredoxin-NADP+ reductase activity
C2U64_RS16420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U64_RS16430	COG0456	acetyltransferase
C2U64_RS16445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U64_RS16450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U64_RS16460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U64_RS16475	COG1981	membrane
C2U64_RS16485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U64_RS16485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U64_RS16505	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS16510	COG4638	Rieske (2fe-2S)
C2U64_RS16515	COG0657	acetylesterase activity
C2U64_RS16525	COG0473	3-isopropylmalate dehydrogenase activity
C2U64_RS16530	COG0583	DNA-binding transcription factor activity
C2U64_RS16550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U64_RS16585	COG0358	DNA primase activity
C2U64_RS16600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U64_RS16630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U64_RS16660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U64_RS16670	COG0351	phosphomethylpyrimidine kinase
C2U64_RS16670	COG0352	thiamine-phosphate diphosphorylase activity
C2U64_RS16670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U64_RS16675	COG1652	LysM domain
C2U64_RS16700	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U64_RS16705	COG3101	peptidyl-lysine hydroxylation
C2U64_RS16710	COG0009	L-threonylcarbamoyladenylate synthase
C2U64_RS16715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2U64_RS16720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U64_RS16735	COG4106	trans-aconitate 2-methyltransferase activity
C2U64_RS16750	COG2226	methyltransferase
C2U64_RS16750	COG0596	Alpha beta hydrolase
C2U64_RS16750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U64_RS16760	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C2U64_RS16765	COG2223	nitrite transmembrane transporter activity
C2U64_RS16785	COG1196	nuclear chromosome segregation
C2U64_RS16795	COG0730	response to heat
C2U64_RS16810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U64_RS16820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U64_RS16875	COG0489	protein tyrosine kinase activity
C2U64_RS16885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U64_RS16885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U64_RS16920	COG3328	transposase activity
C2U64_RS16925	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2U64_RS16930	COG2081	HI0933 family
C2U64_RS16940	COG0668	transmembrane transport
C2U64_RS16960	COG0583	DNA-binding transcription factor activity
C2U64_RS16980	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U64_RS16985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U64_RS17015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C2U64_RS17040	COG2199	diguanylate cyclase activity
C2U64_RS17055	COG0745	RESPONSE REGULATOR receiver
C2U64_RS17070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U64_RS17090	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS17120	COG0110	maltose O-acetyltransferase activity
C2U64_RS17125	COG0438	transferase activity, transferring glycosyl groups
C2U64_RS17200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U64_RS17215	COG0583	DNA-binding transcription factor activity
C2U64_RS17250	COG0583	DNA-binding transcription factor activity
C2U64_RS17270	COG0583	DNA-binding transcription factor activity
C2U64_RS17275	COG1053	succinate dehydrogenase
C2U64_RS17300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U64_RS17305	COG2814	Major facilitator Superfamily
C2U64_RS17310	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS17315	COG0583	DNA-binding transcription factor activity
C2U64_RS17340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U64_RS17345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2U64_RS17350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U64_RS17370	COG2132	Multicopper oxidase
C2U64_RS17380	COG0561	phosphatase activity
C2U64_RS17385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U64_RS17395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2U64_RS17410	COG1214	PFAM Peptidase M22, glycoprotease
C2U64_RS17470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U64_RS17475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U64_RS17480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U64_RS17540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U64_RS17550	COG1846	Transcriptional regulator
C2U64_RS17555	COG1764	response to oxidative stress
C2U64_RS17595	COG0037	tRNA processing
C2U64_RS17605	COG0248	Ppx GppA phosphatase
C2U64_RS17635	COG0072	phenylalanine-tRNA ligase activity
C2U64_RS17660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U64_RS17675	COG1238	metal cluster binding
C2U64_RS17680	COG0625	glutathione transferase activity
C2U64_RS17700	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_RS17705	COG3028	Belongs to the UPF0307 family
C2U64_RS17710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U64_RS17730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U64_RS17735	COG0617	tRNA 3'-terminal CCA addition
C2U64_RS17740	COG1555	photosystem II stabilization
C2U64_RS17745	COG3956	TIGRFAM MazG family protein
C2U64_RS17750	COG4221	oxidoreductase activity
C2U64_RS17755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U64_RS17770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U64_RS17775	COG5002	protein histidine kinase activity
C2U64_RS17775	COG0784	Response regulator, receiver
C2U64_RS17775	COG2205	protein histidine kinase activity
C2U64_RS17780	COG1024	Enoyl-CoA hydratase
C2U64_RS17785	COG2084	Dehydrogenase
C2U64_RS17790	COG3622	Belongs to the hyi family
C2U64_RS17820	COG0697	spore germination
C2U64_RS17830	COG2814	Major facilitator Superfamily
C2U64_RS17865	COG2072	flavoprotein involved in K transport
C2U64_RS17870	COG0492	ferredoxin-NADP+ reductase activity
C2U64_RS17875	COG0431	NADPH-dependent FMN reductase
C2U64_RS17880	COG0798	PFAM Bile acid sodium symporter
C2U64_RS17890	COG0640	Transcriptional regulator
C2U64_RS17925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U64_RS17950	COG2132	Multicopper oxidase
C2U64_RS17965	COG2205	protein histidine kinase activity
C2U64_RS18045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U64_RS18060	COG0583	DNA-binding transcription factor activity
C2U64_RS18070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U64_RS18080	COG0084	hydrolase, TatD family'
C2U64_RS18095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2U64_RS18110	COG2826	transposase and inactivated derivatives, IS30 family
C2U64_RS18130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U64_RS18135	COG0440	acetolactate synthase activity
C2U64_RS18140	COG0028	Belongs to the TPP enzyme family
C2U64_RS18160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U64_RS18165	COG1136	(ABC) transporter
C2U64_RS18165	COG0577	efflux transmembrane transporter activity
C2U64_RS18200	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U64_RS18205	COG1162	GTPase activity
C2U64_RS18215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U64_RS18235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U64_RS18255	COG1426	Protein conserved in bacteria
C2U64_RS18290	COG0793	Belongs to the peptidase S41A family
C2U64_RS18305	COG2267	carboxylic ester hydrolase activity
C2U64_RS18315	COG1012	belongs to the aldehyde dehydrogenase family
C2U64_RS18320	COG3265	gluconokinase activity
C2U64_RS18330	COG0800	Aldolase
C2U64_RS18345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U64_RS18350	COG0857	belongs to the CobB CobQ family
C2U64_RS18350	COG0280	phosphate acetyltransferase
C2U64_RS18355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U64_RS18355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U64_RS18375	COG0740	serine-type endopeptidase activity
C2U64_RS18385	COG4774	siderophore transport
C2U64_RS18395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U64_RS18405	COG2813	Specifically methylates the guanine in position
C2U64_RS18405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U64_RS18505	COG0788	formyltetrahydrofolate deformylase activity
C2U64_RS18530	COG4651	solute:proton antiporter activity
C2U64_RS18530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U64_RS18550	COG0724	RNA recognition motif
C2U64_RS18555	COG0210	DNA helicase
C2U64_RS18580	COG1733	regulation of RNA biosynthetic process
C2U64_RS18585	COG0604	alcohol dehydrogenase
C2U64_RS18590	COG2900	Belongs to the SlyX family
C2U64_RS18595	COG0488	(ABC) transporter
C2U64_RS18605	COG1560	Kdo2-lipid A biosynthetic process
C2U64_RS18615	COG1301	dicarboxylic acid transport
C2U64_RS18670	COG0473	3-isopropylmalate dehydrogenase activity
C2U64_RS18695	COG0583	DNA-binding transcription factor activity
C2U64_RS18740	COG0583	DNA-binding transcription factor activity
C2U64_RS18750	COG0625	glutathione transferase activity
C2U64_RS18755	COG2378	regulation of single-species biofilm formation
C2U64_RS18760	COG0546	phosphoglycolate phosphatase activity
C2U64_RS18775	COG1530	ribonuclease E activity
C2U64_RS18780	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_RS18795	COG0583	DNA-binding transcription factor activity
C2U64_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS18805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U64_RS18815	COG0534	Mate efflux family protein
C2U64_RS18830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U64_RS18855	COG0493	'glutamate synthase
C2U64_RS18865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U64_RS18870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U64_RS18885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2U64_RS18895	COG0644	oxidoreductase
C2U64_RS18895	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C2U64_RS18910	COG4535	Mg2 and Co2 transporter CorC
C2U64_RS18920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U64_RS18940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U64_RS18950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U64_RS18960	COG0484	heat shock protein binding
C2U64_RS18965	COG0789	Transcriptional regulator
C2U64_RS18970	COG0598	Magnesium transport protein CorA
C2U64_RS18975	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U64_RS18985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2U64_RS18990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U64_RS18995	COG1074	ATP-dependent DNA helicase activity
C2U64_RS19000	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U64_RS19020	COG2226	methyltransferase
C2U64_RS19035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U64_RS19045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U64_RS19060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U64_RS19060	COG2111	Na H antiporter
C2U64_RS19065	COG1006	Multisubunit Na H antiporter MnhC subunit
C2U64_RS19070	COG0651	ATP synthesis coupled electron transport
C2U64_RS19075	COG1863	multisubunit Na H antiporter MnhE subunit
C2U64_RS19080	COG2212	antiporter activity
C2U64_RS19085	COG1320	monovalent cation:proton antiporter activity
C2U64_RS19090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U64_RS19100	COG0195	Participates in both transcription termination and antitermination
C2U64_RS19150	COG0237	dephospho-CoA kinase activity
C2U64_RS19160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U64_RS19175	COG0497	DNA recombination
C2U64_RS19185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U64_RS19220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U64_RS19220	COG2169	Transcriptional regulator
C2U64_RS19225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U64_RS19295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2U64_RS19310	COG0326	Molecular chaperone. Has ATPase activity
C2U64_RS19325	COG2056	Na+-H+ antiporter family
C2U64_RS19395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U64_RS19425	COG0546	phosphoglycolate phosphatase activity
C2U64_RS19430	COG1716	ATPase activity
C2U64_RS19475	COG0181	hydroxymethylbilane synthase activity
C2U64_RS19485	COG3275	phosphorelay sensor kinase activity
C2U64_RS19505	COG1538	Outer membrane efflux protein
C2U64_RS19515	COG0697	spore germination
C2U64_RS19535	COG0494	nUDIX hydrolase
C2U64_RS19540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U64_RS19545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U64_RS19550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U64_RS19555	COG0772	Belongs to the SEDS family
C2U64_RS19580	COG4974	Belongs to the 'phage' integrase family
C2U64_RS19585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U64_RS19595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U64_RS19605	COG2197	response regulator
C2U64_RS19620	COG0793	Belongs to the peptidase S41A family
C2U64_RS19625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U64_RS19630	COG0795	lipopolysaccharide-transporting ATPase activity
C2U64_RS19670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U64_RS19670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U64_RS19680	COG0004	ammonium transporteR
C2U64_RS19685	COG0347	Belongs to the P(II) protein family
C2U64_RS19695	COG0606	chelatase, subunit chli
C2U64_RS19700	COG0431	NADPH-dependent FMN reductase
C2U64_RS19705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_RS19710	COG0235	Class ii aldolase
C2U64_RS19715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U64_RS19735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U64_RS19750	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_RS19760	COG0477	Major facilitator Superfamily
C2U64_RS19765	COG2860	membrane
C2U64_RS19775	COG1253	flavin adenine dinucleotide binding
C2U64_RS19785	COG2814	Major facilitator Superfamily
C2U64_RS19795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U64_RS19835	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2U64_RS19850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U64_RS19880	COG1309	transcriptional regulator
C2U64_RS19915	COG0758	DNA mediated transformation
C2U64_RS19925	COG0697	spore germination
C2U64_RS19930	COG1309	transcriptional regulator
C2U64_RS19945	COG0386	Belongs to the glutathione peroxidase family
C2U64_RS19960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U64_RS19970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U64_RS20010	COG1121	(ABC) transporter
C2U64_RS20015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U64_RS20020	COG1280	lysine exporter protein (LysE YggA)
C2U64_RS20025	COG2837	iron assimilation
C2U64_RS20030	COG0281	malic enzyme
C2U64_RS20075	COG0519	Catalyzes the synthesis of GMP from XMP
C2U64_RS20075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U64_RS20080	COG4399	Belongs to the UPF0754 family
C2U64_RS20085	COG2259	Doxx family
C2U64_RS20090	COG0586	Pfam SNARE associated Golgi protein
C2U64_RS20105	COG1192	Involved in chromosome partitioning
C2U64_RS20115	COG0271	Belongs to the BolA IbaG family
C2U64_RS20155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U64_RS20155	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2U64_RS20155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U64_RS20155	COG3321	synthase
C2U64_RS20160	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS20165	COG0318	PFAM AMP-dependent synthetase and ligase
C2U64_RS20170	COG2197	response regulator
C2U64_RS20180	COG3916	Acyl-homoserine-lactone synthase
C2U64_RS20185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U64_RS20195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U64_RS20200	COG1113	amino acid transport
C2U64_RS20205	COG0697	spore germination
C2U64_RS20210	COG0477	Major facilitator Superfamily
C2U64_RS20215	COG1024	Enoyl-CoA hydratase
C2U64_RS20220	COG1024	Enoyl-CoA hydratase
C2U64_RS20225	COG1960	acyl-CoA dehydrogenase activity
C2U64_RS20230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U64_RS20250	COG1113	amino acid transport
C2U64_RS20255	COG1113	amino acid transport
C2U64_RS20260	COG0251	oxidation-reduction process
C2U64_RS20300	COG0564	pseudouridine synthase activity
C2U64_RS20320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U64_RS20335	COG1051	belongs to the nudix hydrolase family
C2U64_RS20355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2U64_RS20370	COG1802	Transcriptional regulator
C2U64_RS20380	COG1448	Aminotransferase
C2U64_RS20385	COG0277	FAD linked oxidase domain protein
C2U64_RS20395	COG2186	Transcriptional regulator
C2U64_RS20405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U64_RS20420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U64_RS20425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U64_RS20460	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U64_RS20470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2U64_RS20490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U64_RS20520	COG0728	peptidoglycan biosynthetic process
C2U64_RS20525	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U64_RS20580	COG0546	phosphoglycolate phosphatase activity
C2U64_RS20585	COG1028	Short-chain dehydrogenase reductase Sdr
C2U64_RS20600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U64_RS20600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U64_RS20605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_RS20610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U64_RS20615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U64_RS20620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U64_RS20625	COG1116	anion transmembrane transporter activity
C2U64_RS20630	COG1309	transcriptional regulator
C2U64_RS20635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U64_RS20645	COG0196	riboflavin kinase activity
C2U64_RS20650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U64_RS20660	COG1047	Peptidyl-prolyl cis-trans
C2U64_RS20700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U64_RS20705	COG0657	acetylesterase activity
C2U64_RS20755	COG2951	lytic endotransglycosylase activity
C2U64_RS20760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U64_RS20775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U64_RS20785	COG3328	transposase activity
C2U64_RS20795	COG0671	phosphoesterase, PA-phosphatase related
C2U64_RS20800	COG0861	Integral membrane protein TerC family
C2U64_RS20810	COG0754	glutathionylspermidine amidase activity
C2U64_RS20820	COG0402	S-adenosylhomocysteine deaminase activity
C2U64_RS20835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U64_RS20855	COG0706	membrane insertase activity