locus-tag	class	description
MZO21_RS00010	COG0592	DNA-directed DNA polymerase activity
MZO21_RS00020	COG0187	DNA topoisomerase II activity
MZO21_RS00030	COG0488	(ABC) transporter
MZO21_RS00040	COG0583	DNA-binding transcription factor activity
MZO21_RS00055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MZO21_RS00060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MZO21_RS00090	COG2814	Major facilitator Superfamily
MZO21_RS00110	COG1047	Peptidyl-prolyl cis-trans
MZO21_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MZO21_RS00125	COG0196	riboflavin kinase activity
MZO21_RS00140	COG1309	transcriptional regulator
MZO21_RS00145	COG1116	anion transmembrane transporter activity
MZO21_RS00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MZO21_RS00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MZO21_RS00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MZO21_RS00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MZO21_RS00170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MZO21_RS00170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MZO21_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
MZO21_RS00205	COG0546	phosphoglycolate phosphatase activity
MZO21_RS00210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MZO21_RS00220	COG1309	transcriptional regulator
MZO21_RS00225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MZO21_RS00235	COG3023	N-Acetylmuramoyl-L-alanine amidase
MZO21_RS00240	COG0728	peptidoglycan biosynthetic process
MZO21_RS00260	COG0156	8-amino-7-oxononanoate synthase activity
MZO21_RS00265	COG2818	Glycosylase
MZO21_RS00275	COG0739	heme binding
MZO21_RS00295	COG5487	UPF0391 membrane protein
MZO21_RS00300	COG2983	Belongs to the UPF0260 family
MZO21_RS00305	COG1683	Conserved Protein
MZO21_RS00310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MZO21_RS00345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MZO21_RS00350	COG2814	Major facilitator Superfamily
MZO21_RS00355	COG1335	isochorismatase
MZO21_RS00360	COG0385	Bile acid
MZO21_RS00370	COG3830	Belongs to the UPF0237 family
MZO21_RS00370	COG0560	Phosphoserine phosphatase
MZO21_RS00385	COG3385	transposase activity
MZO21_RS00395	COG0753	catalase activity
MZO21_RS00435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MZO21_RS00440	COG0534	Mate efflux family protein
MZO21_RS00445	COG0436	Aminotransferase
MZO21_RS00450	COG2733	membrane
MZO21_RS00465	COG2918	glutathione biosynthetic process
MZO21_RS00470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MZO21_RS00480	COG3150	esterase
MZO21_RS00545	COG1393	Belongs to the ArsC family
MZO21_RS00550	COG0708	Exodeoxyribonuclease III
MZO21_RS00585	COG0189	ligase activity
MZO21_RS00610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MZO21_RS00620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MZO21_RS00650	COG2119	membrane
MZO21_RS00670	COG0259	pyridoxamine-phosphate oxidase activity
MZO21_RS00675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MZO21_RS00695	COG1902	pentaerythritol trinitrate reductase activity
MZO21_RS00700	COG1519	Transferase
MZO21_RS00705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MZO21_RS00710	COG0668	transmembrane transport
MZO21_RS00720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MZO21_RS00730	COG0307	riboflavin synthase, alpha
MZO21_RS00735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MZO21_RS00750	COG5002	protein histidine kinase activity
MZO21_RS00755	COG3162	membrane
MZO21_RS00760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MZO21_RS00765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MZO21_RS00790	COG2826	transposase and inactivated derivatives, IS30 family
MZO21_RS00795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MZO21_RS00800	COG3759	membrane
MZO21_RS00815	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MZO21_RS00825	COG2814	Major facilitator Superfamily
MZO21_RS00855	COG0583	DNA-binding transcription factor activity
MZO21_RS00860	COG1335	isochorismatase
MZO21_RS00875	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MZO21_RS00900	COG3158	transport of potassium into the cell
MZO21_RS00940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MZO21_RS00970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MZO21_RS01005	COG0427	acetyl-CoA hydrolase
MZO21_RS01035	COG4221	oxidoreductase activity
MZO21_RS01040	COG2873	o-acetylhomoserine
MZO21_RS01045	COG0488	(ABC) transporter
MZO21_RS01080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MZO21_RS01100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MZO21_RS01105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MZO21_RS01115	COG2226	methyltransferase
MZO21_RS01155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MZO21_RS01165	COG0067	glutamate synthase
MZO21_RS01165	COG0069	glutamate synthase activity
MZO21_RS01165	COG0070	glutamate synthase
MZO21_RS01170	COG0493	'glutamate synthase
MZO21_RS01175	COG1704	LemA family
MZO21_RS01205	COG0463	Glycosyl transferase, family 2
MZO21_RS01210	COG1132	(ABC) transporter
MZO21_RS01250	COG3307	-O-antigen
MZO21_RS01270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MZO21_RS01275	COG1758	RNA polymerase activity
MZO21_RS01280	COG0194	GDP metabolic process
MZO21_RS01285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MZO21_RS01340	COG0228	four-way junction DNA binding
MZO21_RS01345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MZO21_RS01355	COG0335	large ribosomal subunit rRNA binding
MZO21_RS01360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MZO21_RS01380	COG5006	permease, DMT superfamily
MZO21_RS01385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MZO21_RS01390	COG0277	FAD linked oxidase domain protein
MZO21_RS01425	COG2814	Major facilitator Superfamily
MZO21_RS01435	COG1289	transmembrane transporter activity
MZO21_RS01445	COG0628	permease
MZO21_RS01470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MZO21_RS01475	COG0254	rRNA binding
MZO21_RS01480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MZO21_RS01485	COG0534	Mate efflux family protein
MZO21_RS01495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MZO21_RS01500	COG1960	acyl-CoA dehydrogenase activity
MZO21_RS01515	COG0408	coproporphyrinogen oxidase activity
MZO21_RS01520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MZO21_RS01550	COG1127	ABC transporter
MZO21_RS01555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MZO21_RS01560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MZO21_RS01565	COG2854	intermembrane phospholipid transfer
MZO21_RS01575	COG0598	Magnesium transport protein CorA
MZO21_RS01590	COG1040	competence protein
MZO21_RS01610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MZO21_RS01620	COG2937	Belongs to the GPAT DAPAT family
MZO21_RS01625	COG1946	Acyl-CoA thioesterase
MZO21_RS01630	COG1301	dicarboxylic acid transport
MZO21_RS01640	COG1959	2 iron, 2 sulfur cluster binding
MZO21_RS01645	COG1017	nitric oxide dioxygenase activity
MZO21_RS01645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MZO21_RS01650	COG0433	COG0433 Predicted ATPase
MZO21_RS01675	COG0088	Forms part of the polypeptide exit tunnel
MZO21_RS01690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MZO21_RS01720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MZO21_RS01740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MZO21_RS01745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MZO21_RS01755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MZO21_RS01780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MZO21_RS01790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MZO21_RS01795	COG0202	RNA polymerase activity
MZO21_RS01800	COG0203	ribosomal protein L17
MZO21_RS01805	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MZO21_RS01815	COG0697	spore germination
MZO21_RS01825	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
MZO21_RS01830	COG0339	signal peptide processing
MZO21_RS01835	COG0557	exoribonuclease II activity
MZO21_RS01865	COG0179	Fumarylacetoacetate (FAA) hydrolase
MZO21_RS01895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MZO21_RS01910	COG0473	3-isopropylmalate dehydrogenase activity
MZO21_RS01930	COG0252	asparaginase activity
MZO21_RS01955	COG1560	Kdo2-lipid A biosynthetic process
MZO21_RS01960	COG0488	(ABC) transporter
MZO21_RS01965	COG2900	Belongs to the SlyX family
MZO21_RS02010	COG1929	Belongs to the glycerate kinase type-1 family
MZO21_RS02015	COG0210	DNA helicase
MZO21_RS02050	COG4651	solute:proton antiporter activity
MZO21_RS02050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MZO21_RS02075	COG0788	formyltetrahydrofolate deformylase activity
MZO21_RS02100	COG0697	spore germination
MZO21_RS02105	COG1295	ribonuclease BN
MZO21_RS02140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MZO21_RS02145	COG1702	phosphate starvation-inducible protein PhoH
MZO21_RS02150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MZO21_RS02155	COG0739	heme binding
MZO21_RS02155	COG0741	lytic transglycosylase activity
MZO21_RS02155	COG1196	nuclear chromosome segregation
MZO21_RS02195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MZO21_RS02200	COG1183	phosphatidylcholine synthase activity
MZO21_RS02235	COG1283	sodium-dependent phosphate transmembrane transporter activity
MZO21_RS02265	COG1607	acyl-coa hydrolase
MZO21_RS02295	COG2350	Protein conserved in bacteria
MZO21_RS02310	COG3781	membrane
MZO21_RS02315	COG2003	Belongs to the UPF0758 family
MZO21_RS02320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MZO21_RS02345	COG1162	GTPase activity
MZO21_RS02350	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MZO21_RS02365	COG1538	Outer membrane efflux protein
MZO21_RS02370	COG0577	efflux transmembrane transporter activity
MZO21_RS02370	COG1136	(ABC) transporter
MZO21_RS02375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO21_RS02380	COG2703	oxygen carrier activity
MZO21_RS02385	COG1466	dna polymerase III delta subunit
MZO21_RS02405	COG0028	Belongs to the TPP enzyme family
MZO21_RS02410	COG0440	acetolactate synthase activity
MZO21_RS02460	COG1426	Protein conserved in bacteria
MZO21_RS02470	COG0124	histidyl-tRNA synthetase
MZO21_RS02475	COG2976	Protein conserved in bacteria
MZO21_RS02480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MZO21_RS02495	COG3956	TIGRFAM MazG family protein
MZO21_RS02500	COG1555	photosystem II stabilization
MZO21_RS02500	COG1596	polysaccharide export
MZO21_RS02505	COG0617	tRNA 3'-terminal CCA addition
MZO21_RS02510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MZO21_RS02520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MZO21_RS02525	COG1660	Displays ATPase and GTPase activities
MZO21_RS02540	COG0318	PFAM AMP-dependent synthetase and ligase
MZO21_RS02550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MZO21_RS02555	COG0625	glutathione transferase activity
MZO21_RS02565	COG1238	metal cluster binding
MZO21_RS02595	COG0072	phenylalanine-tRNA ligase activity
MZO21_RS02620	COG0248	Ppx GppA phosphatase
MZO21_RS02630	COG0037	tRNA processing
MZO21_RS02665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MZO21_RS02680	COG2853	Lipoprotein
MZO21_RS02730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MZO21_RS02740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MZO21_RS02760	COG0494	nUDIX hydrolase
MZO21_RS02770	COG1214	PFAM Peptidase M22, glycoprotease
MZO21_RS02775	COG1968	undecaprenyl-diphosphatase activity
MZO21_RS02795	COG4269	membrane
MZO21_RS02810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MZO21_RS02820	COG2132	Multicopper oxidase
MZO21_RS02840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MZO21_RS02855	COG0183	Belongs to the thiolase family
MZO21_RS02875	COG0833	amino acid
MZO21_RS02885	COG2233	PERMEase
MZO21_RS02890	COG1217	gtp-binding protein TYPA
MZO21_RS02900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MZO21_RS02915	COG1902	pentaerythritol trinitrate reductase activity
MZO21_RS02935	COG0354	folic acid binding
MZO21_RS02940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MZO21_RS03005	COG2824	Alkylphosphonate utilization operon protein PhnA
MZO21_RS03015	COG3422	double-strand break repair
MZO21_RS03025	COG0494	nUDIX hydrolase
MZO21_RS03030	COG3328	transposase activity
MZO21_RS03050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MZO21_RS03055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MZO21_RS03055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MZO21_RS03060	COG0745	RESPONSE REGULATOR receiver
MZO21_RS03065	COG2205	protein histidine kinase activity
MZO21_RS03070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MZO21_RS03085	COG1752	Esterase of the alpha-beta hydrolase superfamily
MZO21_RS03095	COG2814	Major facilitator Superfamily
MZO21_RS03110	COG0745	RESPONSE REGULATOR receiver
MZO21_RS03115	COG0642	Histidine kinase
MZO21_RS03130	COG1126	abc transporter atp-binding protein
MZO21_RS03135	COG0765	amino acid transport
MZO21_RS03140	COG0765	amino acid transport
MZO21_RS03160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MZO21_RS03185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MZO21_RS03210	COG0730	response to heat
MZO21_RS03220	COG1196	nuclear chromosome segregation
MZO21_RS03230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MZO21_RS03235	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MZO21_RS03240	COG2193	ferroxidase activity
MZO21_RS03245	COG1785	Belongs to the alkaline phosphatase family
MZO21_RS03250	COG0596	Alpha beta hydrolase
MZO21_RS03250	COG2226	methyltransferase
MZO21_RS03250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MZO21_RS03265	COG4106	trans-aconitate 2-methyltransferase activity
MZO21_RS03275	COG1187	pseudouridine synthase activity
MZO21_RS03280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MZO21_RS03285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MZO21_RS03290	COG0009	L-threonylcarbamoyladenylate synthase
MZO21_RS03295	COG3101	peptidyl-lysine hydroxylation
MZO21_RS03300	COG1399	metal-binding, possibly nucleic acid-binding protein
MZO21_RS03315	COG1028	Short-chain dehydrogenase reductase Sdr
MZO21_RS03325	COG1652	LysM domain
MZO21_RS03335	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
MZO21_RS03355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MZO21_RS03365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MZO21_RS03370	COG1077	Cell shape determining protein MreB Mrl
MZO21_RS03375	COG1792	Involved in formation and maintenance of cell shape
MZO21_RS03380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MZO21_RS03385	COG0424	maF-like protein
MZO21_RS03400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MZO21_RS03410	COG0560	Phosphoserine phosphatase
MZO21_RS03430	COG1113	amino acid transport
MZO21_RS03435	COG2828	Protein conserved in bacteria
MZO21_RS03440	COG0142	geranyltranstransferase activity
MZO21_RS03450	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZO21_RS03460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZO21_RS03460	COG0649	NAD binding
MZO21_RS03470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MZO21_RS03485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZO21_RS03495	COG0713	ATP synthesis coupled electron transport
MZO21_RS03500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MZO21_RS03505	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZO21_RS03530	COG0583	DNA-binding transcription factor activity
MZO21_RS03555	COG2081	HI0933 family
MZO21_RS03605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MZO21_RS03605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MZO21_RS03625	COG0489	protein tyrosine kinase activity
MZO21_RS03645	COG2358	TRAP transporter, solute receptor (TAXI family
MZO21_RS03660	COG0442	prolyl-tRNA aminoacylation
MZO21_RS03670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO21_RS03695	COG0840	transmembrane signaling receptor activity
MZO21_RS03700	COG2198	Histidine kinase
MZO21_RS03700	COG0643	Histidine kinase
MZO21_RS03700	COG2198	Histidine kinase
MZO21_RS03700	COG0643	Histidine kinase
MZO21_RS03715	COG5510	response to toxic substance
MZO21_RS03725	COG2832	Protein of unknown function (DUF454)
MZO21_RS03780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MZO21_RS03790	COG1289	transmembrane transporter activity
MZO21_RS03800	COG1115	amino acid carrier protein
MZO21_RS03805	COG1752	Esterase of the alpha-beta hydrolase superfamily
MZO21_RS03815	COG1607	acyl-coa hydrolase
MZO21_RS03825	COG2814	Major facilitator Superfamily
MZO21_RS03830	COG0583	DNA-binding transcription factor activity
MZO21_RS03845	COG0523	cobalamin synthesis protein
MZO21_RS03850	COG4681	YaeQ
MZO21_RS03870	COG2852	Protein conserved in bacteria
MZO21_RS03885	COG0306	phosphate transporter
MZO21_RS03910	COG4771	TonB-dependent receptor
MZO21_RS03915	COG0500	methyltransferase
MZO21_RS03920	COG4771	TonB-dependent receptor
MZO21_RS03945	COG4181	ATPase activity
MZO21_RS03950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MZO21_RS03970	COG0583	DNA-binding transcription factor activity
MZO21_RS03980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MZO21_RS03985	COG1773	rubredoxin
MZO21_RS03990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MZO21_RS04050	COG1253	flavin adenine dinucleotide binding
MZO21_RS04090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MZO21_RS04100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MZO21_RS04115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MZO21_RS04120	COG0730	response to heat
MZO21_RS04145	COG0006	proline dipeptidase activity
MZO21_RS04150	COG2801	Transposase and inactivated derivatives
MZO21_RS04160	COG0640	Transcriptional regulator
MZO21_RS04165	COG0798	PFAM Bile acid sodium symporter
MZO21_RS04170	COG0431	NADPH-dependent FMN reductase
MZO21_RS04175	COG2801	Transposase and inactivated derivatives
MZO21_RS04180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MZO21_RS04185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MZO21_RS04215	COG2816	NAD+ diphosphatase activity
MZO21_RS04230	COG0741	lytic transglycosylase activity
MZO21_RS04230	COG1388	LysM domain
MZO21_RS04235	COG4166	transmembrane transport
MZO21_RS04240	COG4174	ABC transporter (Permease)
MZO21_RS04245	COG4239	(ABC) transporter, permease
MZO21_RS04250	COG4172	Belongs to the ABC transporter superfamily
MZO21_RS04270	COG0833	amino acid
MZO21_RS04305	COG4771	TonB-dependent receptor
MZO21_RS04310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MZO21_RS04315	COG0418	dihydroorotase activity
MZO21_RS04330	COG2186	Transcriptional regulator
MZO21_RS04340	COG0277	FAD linked oxidase domain protein
MZO21_RS04345	COG0446	pyridine nucleotide-disulphide oxidoreductase
MZO21_RS04345	COG1902	pentaerythritol trinitrate reductase activity
MZO21_RS04355	COG1741	Belongs to the pirin family
MZO21_RS04370	COG3739	integral membrane protein
MZO21_RS04380	COG0302	gtp cyclohydrolase
MZO21_RS04395	COG3293	Transposase
MZO21_RS04410	COG0765	amino acid transport
MZO21_RS04415	COG0765	amino acid transport
MZO21_RS04420	COG1126	abc transporter atp-binding protein
MZO21_RS04430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MZO21_RS04440	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MZO21_RS04450	COG0281	malic enzyme
MZO21_RS04450	COG0280	phosphate acetyltransferase
MZO21_RS04465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MZO21_RS04470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MZO21_RS04475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MZO21_RS04520	COG3385	transposase activity
MZO21_RS04525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MZO21_RS04530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MZO21_RS04550	COG2175	clavaminate synthase activity
MZO21_RS04565	COG0052	Belongs to the universal ribosomal protein uS2 family
MZO21_RS04585	COG2951	lytic endotransglycosylase activity
MZO21_RS04590	COG0772	Belongs to the SEDS family
MZO21_RS04605	COG0842	Transport permease protein
MZO21_RS04610	COG1131	(ABC) transporter
MZO21_RS04620	COG2826	transposase and inactivated derivatives, IS30 family
MZO21_RS04670	COG2826	transposase and inactivated derivatives, IS30 family
MZO21_RS04685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MZO21_RS04715	COG3634	alkyl hydroperoxide reductase activity
MZO21_RS04720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MZO21_RS04725	COG0826	peptidase U32
MZO21_RS04750	COG1720	tRNA m6t6A37 methyltransferase activity
MZO21_RS04765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MZO21_RS04780	COG0642	Histidine kinase
MZO21_RS04790	COG0494	nUDIX hydrolase
MZO21_RS04800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MZO21_RS04805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MZO21_RS04810	COG3139	Protein of unknown function (DUF1315)
MZO21_RS04820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MZO21_RS04825	COG1960	acyl-CoA dehydrogenase activity
MZO21_RS04835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MZO21_RS04840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MZO21_RS04850	COG2808	Putative FMN-binding domain
MZO21_RS04865	COG2826	transposase and inactivated derivatives, IS30 family
MZO21_RS04880	COG0612	Peptidase, M16
MZO21_RS04890	COG0612	Peptidase, M16
MZO21_RS04915	COG2801	Transposase and inactivated derivatives
MZO21_RS04920	COG2801	Transposase and inactivated derivatives
MZO21_RS04925	COG3025	triphosphatase activity
MZO21_RS04935	COG0352	thiamine-phosphate diphosphorylase activity
MZO21_RS04945	COG3193	protein, possibly involved in utilization of glycolate and propanediol
MZO21_RS04955	COG0564	pseudouridine synthase activity
MZO21_RS04965	COG0436	Aminotransferase
MZO21_RS04975	COG2199	diguanylate cyclase activity
MZO21_RS04985	COG0556	nucleotide-excision repair
MZO21_RS05020	COG0702	epimerase
MZO21_RS05025	COG1733	regulation of RNA biosynthetic process
MZO21_RS05030	COG1278	Cold shock
MZO21_RS05035	COG2814	Major facilitator Superfamily
MZO21_RS05045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MZO21_RS05055	COG0671	phosphoesterase, PA-phosphatase related
MZO21_RS05065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MZO21_RS05070	COG0076	glutamate decarboxylase activity
MZO21_RS05075	COG0402	S-adenosylhomocysteine deaminase activity
MZO21_RS05085	COG0573	inorganic phosphate transmembrane transporter activity
MZO21_RS05090	COG0581	inorganic phosphate transmembrane transporter activity
MZO21_RS05095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MZO21_RS05100	COG0616	signal peptide processing
MZO21_RS05125	COG2915	High frequency lysogenization protein hflD homolog
MZO21_RS05130	COG0482	sulfurtransferase activity
MZO21_RS05140	COG1231	oxidoreductase activity
MZO21_RS05155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MZO21_RS05160	COG1686	Belongs to the peptidase S11 family
MZO21_RS05180	COG1388	LysM domain
MZO21_RS05180	COG4942	peptidase
MZO21_RS05185	COG0583	DNA-binding transcription factor activity
MZO21_RS05190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MZO21_RS05195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MZO21_RS05200	COG1067	ATP-dependent peptidase activity
MZO21_RS05240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MZO21_RS05245	COG1966	Carbon starvation protein
MZO21_RS05250	COG2879	small protein
MZO21_RS05255	COG0714	Associated with various cellular activities
MZO21_RS05285	COG2252	PERMEase
MZO21_RS05290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MZO21_RS05310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MZO21_RS05320	COG0527	aspartate kinase activity
MZO21_RS05330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MZO21_RS05340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MZO21_RS05355	COG0667	Aldo Keto reductase
MZO21_RS05365	COG1765	OsmC-like protein
MZO21_RS05370	COG0542	response to heat
MZO21_RS05375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MZO21_RS05375	COG0116	Belongs to the methyltransferase superfamily
MZO21_RS05385	COG1686	Belongs to the peptidase S11 family
MZO21_RS05415	COG0540	Belongs to the ATCase OTCase family
MZO21_RS05435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MZO21_RS05440	COG0659	secondary active sulfate transmembrane transporter activity
MZO21_RS05460	COG2363	Small membrane protein
MZO21_RS05475	COG1278	Cold shock
MZO21_RS05480	COG0513	Belongs to the DEAD box helicase family
MZO21_RS05490	COG0778	Nitroreductase
MZO21_RS05495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MZO21_RS05505	COG0167	dihydroorotate dehydrogenase activity
MZO21_RS05530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MZO21_RS05535	COG4783	chaperone-mediated protein folding
MZO21_RS05540	COG1610	YqeY-like protein
MZO21_RS05600	COG2011	ABC-type metal ion transport system permease component
MZO21_RS05605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MZO21_RS05620	COG0138	bifunctional purine biosynthesis protein purh
MZO21_RS05625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MZO21_RS05650	COG2814	Major facilitator Superfamily
MZO21_RS05680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MZO21_RS05700	COG0360	Binds together with S18 to 16S ribosomal RNA
MZO21_RS05710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MZO21_RS05715	COG1845	cytochrome c oxidase, subunit III
MZO21_RS05720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MZO21_RS05725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MZO21_RS05750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MZO21_RS05765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MZO21_RS05770	COG2890	protein-(glutamine-N5) methyltransferase activity
MZO21_RS05835	COG2199	diguanylate cyclase activity
MZO21_RS05855	COG0439	Biotin carboxylase
MZO21_RS05860	COG0511	ligase activity, forming carbon-carbon bonds
MZO21_RS05865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MZO21_RS05880	COG0308	aminopeptidase N
MZO21_RS05890	COG0589	response to stress
MZO21_RS05905	COG3135	benzoate transporter
MZO21_RS05915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MZO21_RS05920	COG0583	DNA-binding transcription factor activity
MZO21_RS05930	COG0183	Belongs to the thiolase family
MZO21_RS05945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MZO21_RS05960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MZO21_RS05980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MZO21_RS06005	COG0069	glutamate synthase activity
MZO21_RS06010	COG2850	peptidyl-arginine hydroxylation
MZO21_RS06015	COG0424	maF-like protein
MZO21_RS06025	COG0126	phosphoglycerate kinase activity
MZO21_RS06040	COG0697	spore germination
MZO21_RS06090	COG3077	Addiction module antitoxin, RelB DinJ family
MZO21_RS06095	COG2026	Addiction module toxin, RelE StbE family
MZO21_RS06100	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MZO21_RS06100	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MZO21_RS06100	COG0506	proline dehydrogenase activity
MZO21_RS06110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MZO21_RS06120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MZO21_RS06125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MZO21_RS06150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MZO21_RS06155	COG0542	response to heat
MZO21_RS06175	COG0596	Alpha beta hydrolase
MZO21_RS06180	COG2801	Transposase and inactivated derivatives
MZO21_RS06185	COG2801	Transposase and inactivated derivatives
MZO21_RS06190	COG4628	conserved protein (DUF2132)
MZO21_RS06195	COG3958	Transketolase
MZO21_RS06200	COG3959	Transketolase, thiamine diphosphate binding domain
MZO21_RS06205	COG2271	Major facilitator Superfamily
MZO21_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
MZO21_RS06215	COG0583	DNA-binding transcription factor activity
MZO21_RS06230	COG1454	alcohol dehydrogenase
MZO21_RS06240	COG1064	alcohol dehydrogenase
MZO21_RS06250	COG0583	DNA-binding transcription factor activity
MZO21_RS06255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MZO21_RS06260	COG2937	Belongs to the GPAT DAPAT family
MZO21_RS06285	COG3122	Protein conserved in bacteria
MZO21_RS06295	COG1132	(ABC) transporter
MZO21_RS06305	COG0509	glycine decarboxylation via glycine cleavage system
MZO21_RS06325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MZO21_RS06335	COG0697	spore germination
MZO21_RS06355	COG2814	Major facilitator Superfamily
MZO21_RS06385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MZO21_RS06410	COG0730	response to heat
MZO21_RS06415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MZO21_RS06445	COG0772	Belongs to the SEDS family
MZO21_RS06460	COG0148	phosphopyruvate hydratase activity
MZO21_RS06485	COG0446	pyridine nucleotide-disulphide oxidoreductase
MZO21_RS06485	COG1902	pentaerythritol trinitrate reductase activity
MZO21_RS06495	COG2267	carboxylic ester hydrolase activity
MZO21_RS06500	COG0569	domain protein
MZO21_RS06505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MZO21_RS06525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MZO21_RS06550	COG1294	oxidase, subunit
MZO21_RS06555	COG4890	Cyd operon protein YbgT
MZO21_RS06595	COG1525	nuclease
MZO21_RS06615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MZO21_RS06620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MZO21_RS06640	COG0786	glutamate:sodium symporter activity
MZO21_RS06645	COG2353	YceI-like domain
MZO21_RS06700	COG0729	surface antigen
MZO21_RS06705	COG0477	Major facilitator Superfamily
MZO21_RS06715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZO21_RS06720	COG0372	Belongs to the citrate synthase family
MZO21_RS06740	COG3713	MltA-interacting MipA family protein
MZO21_RS06745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MZO21_RS06755	COG0505	Belongs to the CarA family
MZO21_RS06825	COG0552	protein localization to endoplasmic reticulum
MZO21_RS06850	COG0517	IMP dehydrogenase activity
MZO21_RS06860	COG0133	tryptophan synthase activity
MZO21_RS06875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MZO21_RS06880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MZO21_RS06895	COG1280	lysine exporter protein (LysE YggA)
MZO21_RS06915	COG3328	transposase activity
MZO21_RS06925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MZO21_RS06925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MZO21_RS06995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MZO21_RS07025	COG0537	adenosine 5'-monophosphoramidase activity
MZO21_RS07065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MZO21_RS07070	COG0776	regulation of translation
MZO21_RS07080	COG1959	2 iron, 2 sulfur cluster binding
MZO21_RS07090	COG0822	iron-sulfur transferase activity
MZO21_RS07095	COG0316	Belongs to the HesB IscA family
MZO21_RS07125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MZO21_RS07135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MZO21_RS07140	COG0702	epimerase
MZO21_RS07165	COG1011	Hydrolase
MZO21_RS07170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MZO21_RS07180	COG2137	regulation of response to DNA damage stimulus
MZO21_RS07195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MZO21_RS07205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MZO21_RS07215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MZO21_RS07230	COG0575	Belongs to the CDS family
MZO21_RS07235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MZO21_RS07255	COG3852	Histidine kinase
MZO21_RS07270	COG0288	reversible hydration of carbon dioxide
MZO21_RS07280	COG0583	DNA-binding transcription factor activity
MZO21_RS07285	COG0024	Methionine aminopeptidase
MZO21_RS07305	COG3385	transposase activity
MZO21_RS07310	COG1253	flavin adenine dinucleotide binding
MZO21_RS07320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MZO21_RS07325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MZO21_RS07340	COG2431	L-lysine efflux transmembrane transporter activity
MZO21_RS07385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MZO21_RS07395	COG1309	transcriptional regulator
MZO21_RS07400	COG0084	hydrolase, TatD family'
MZO21_RS07420	COG1663	tetraacyldisaccharide 4'-kinase activity
MZO21_RS07425	COG1132	(ABC) transporter
MZO21_RS07435	COG0811	peptide transport
MZO21_RS07440	COG1475	DNA binding
MZO21_RS07445	COG1192	Involved in chromosome partitioning
MZO21_RS07455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MZO21_RS07470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MZO21_RS07475	COG3385	transposase activity
MZO21_RS07480	COG1923	regulation of RNA biosynthetic process
MZO21_RS07490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MZO21_RS07495	COG0802	atpase or kinase
MZO21_RS07515	COG2707	UPF0756 membrane protein
MZO21_RS07520	COG0583	DNA-binding transcription factor activity
MZO21_RS07525	COG1944	ATP diphosphatase activity
MZO21_RS07545	COG0642	Histidine kinase
MZO21_RS07560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MZO21_RS07605	COG2072	flavoprotein involved in K transport
MZO21_RS07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MZO21_RS07635	COG5285	phytanoyl-CoA dioxygenase
MZO21_RS07645	COG1126	abc transporter atp-binding protein
MZO21_RS07655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MZO21_RS07660	COG0583	DNA-binding transcription factor activity
MZO21_RS07675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MZO21_RS07685	COG0579	oxidoreductase
MZO21_RS07695	COG3842	ATPase activity
MZO21_RS07700	COG1840	ABC-type Fe3 transport system, periplasmic component
MZO21_RS07735	COG0012	GTP binding
MZO21_RS07740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MZO21_RS07750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MZO21_RS07760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MZO21_RS07775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MZO21_RS07790	COG0386	Belongs to the glutathione peroxidase family
MZO21_RS07795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MZO21_RS07800	COG0436	Aminotransferase
MZO21_RS07820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MZO21_RS07865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MZO21_RS07875	COG4122	O-methyltransferase activity
MZO21_RS07880	COG0589	response to stress
MZO21_RS07910	COG1137	ATPase activity
MZO21_RS07915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MZO21_RS07925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MZO21_RS07930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MZO21_RS07930	COG0517	IMP dehydrogenase activity
MZO21_RS07965	COG1643	Atp-dependent helicase
MZO21_RS08000	COG3634	alkyl hydroperoxide reductase activity
MZO21_RS08015	COG2391	methyltransferase activity
MZO21_RS08030	COG2826	transposase and inactivated derivatives, IS30 family
MZO21_RS08050	COG1301	dicarboxylic acid transport
MZO21_RS08070	COG2070	2-Nitropropane dioxygenase
MZO21_RS08125	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MZO21_RS08130	COG1381	Involved in DNA repair and RecF pathway recombination
MZO21_RS08140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MZO21_RS08145	COG0571	ribonuclease III activity
MZO21_RS08155	COG0681	Belongs to the peptidase S26 family
MZO21_RS08175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MZO21_RS08220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MZO21_RS08230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MZO21_RS08245	COG4208	sulfate ABC transporter
MZO21_RS08250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MZO21_RS08255	COG0583	DNA-binding transcription factor activity
MZO21_RS08270	COG0602	queuosine metabolic process
MZO21_RS08275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MZO21_RS08285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MZO21_RS08295	COG0583	DNA-binding transcription factor activity
MZO21_RS08300	COG1051	belongs to the nudix hydrolase family
MZO21_RS08300	COG1056	cytidyltransferase-related domain
MZO21_RS08305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MZO21_RS08310	COG0778	Nitroreductase
MZO21_RS08330	COG3180	Ammonia monooxygenase
MZO21_RS08335	COG3323	Protein of unknown function (DUF1653)
MZO21_RS08335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MZO21_RS08340	COG0583	DNA-binding transcription factor activity
MZO21_RS08350	COG0047	phosphoribosylformylglycinamidine synthase activity
MZO21_RS08350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MZO21_RS08370	COG2255	four-way junction helicase activity
MZO21_RS08385	COG0824	Thioesterase
MZO21_RS08405	COG0823	Involved in the tonB-independent uptake of proteins
MZO21_RS08425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MZO21_RS08445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MZO21_RS08450	COG0628	permease
MZO21_RS08460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MZO21_RS08485	COG1136	(ABC) transporter
MZO21_RS08490	COG4591	ABC-type transport system involved in lipoprotein release permease component
MZO21_RS08500	COG0697	spore germination
MZO21_RS08505	COG1671	Belongs to the UPF0178 family
MZO21_RS08530	COG1301	dicarboxylic acid transport
MZO21_RS08535	COG1301	dicarboxylic acid transport
MZO21_RS08570	COG1280	lysine exporter protein (LysE YggA)
MZO21_RS08585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MZO21_RS08595	COG0019	diaminopimelate decarboxylase activity
MZO21_RS08605	COG1113	amino acid transport
MZO21_RS08610	COG1115	amino acid carrier protein
MZO21_RS08640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MZO21_RS08645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MZO21_RS08650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MZO21_RS08685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MZO21_RS08700	COG0174	glutamine synthetase
MZO21_RS08705	COG3293	Transposase
MZO21_RS08710	COG0512	Glutamine amidotransferase of anthranilate synthase
MZO21_RS08715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MZO21_RS08725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MZO21_RS08730	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MZO21_RS08740	COG0037	tRNA processing
MZO21_RS08745	COG0739	heme binding
MZO21_RS08745	COG0741	lytic transglycosylase activity
MZO21_RS08745	COG1196	nuclear chromosome segregation
MZO21_RS08750	COG0501	Belongs to the peptidase M48B family
MZO21_RS08760	COG2239	Acts as a magnesium transporter
MZO21_RS08765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MZO21_RS08775	COG0584	glycerophosphoryl diester phosphodiesterase
MZO21_RS08800	COG0477	Major facilitator Superfamily
MZO21_RS08815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MZO21_RS08840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MZO21_RS08870	COG3384	dioxygenase
MZO21_RS08880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MZO21_RS08885	COG2878	Part of a membrane complex involved in electron transport
MZO21_RS08890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MZO21_RS08910	COG0768	penicillin binding
MZO21_RS08915	COG0742	ribosomal rna small subunit methyltransferase
MZO21_RS08950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MZO21_RS08955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZO21_RS08975	COG0505	Belongs to the CarA family
MZO21_RS08980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MZO21_RS08990	COG0415	Belongs to the DNA photolyase family
MZO21_RS08995	COG0110	maltose O-acetyltransferase activity
MZO21_RS09015	COG0589	response to stress
MZO21_RS09030	COG2321	neutral zinc metallopeptidase
MZO21_RS09035	COG2354	Protein conserved in bacteria
MZO21_RS09055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MZO21_RS09070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MZO21_RS09075	COG1053	succinate dehydrogenase
MZO21_RS09080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MZO21_RS09115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MZO21_RS09115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MZO21_RS09140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MZO21_RS09165	COG0564	pseudouridine synthase activity
MZO21_RS09175	COG0358	DNA primase activity
MZO21_RS09180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MZO21_RS09190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MZO21_RS09220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MZO21_RS09225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MZO21_RS09250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MZO21_RS09270	COG0586	Pfam SNARE associated Golgi protein
MZO21_RS09300	COG0321	lipoyl(octanoyl) transferase activity
MZO21_RS09315	COG0531	amino acid
MZO21_RS09325	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MZO21_RS09330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MZO21_RS09330	COG1648	precorrin-2 dehydrogenase activity
MZO21_RS09335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MZO21_RS09345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MZO21_RS09350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MZO21_RS09355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MZO21_RS09370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO21_RS09375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MZO21_RS09380	COG1538	Outer membrane efflux protein
MZO21_RS09385	COG0393	Putative heavy-metal-binding
MZO21_RS09390	COG0393	Putative heavy-metal-binding
MZO21_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
MZO21_RS09405	COG0525	valine-tRNA ligase activity
MZO21_RS09415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MZO21_RS09465	COG1802	Transcriptional regulator
MZO21_RS09480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MZO21_RS09485	COG2814	Major facilitator Superfamily
MZO21_RS09490	COG1566	PFAM secretion protein HlyD family protein
MZO21_RS09495	COG2050	protein possibly involved in aromatic compounds catabolism
MZO21_RS09510	COG3706	GGDEF domain
MZO21_RS09540	COG2203	Gaf domain
MZO21_RS09540	COG3706	GGDEF domain
MZO21_RS09540	COG4251	negative regulation of phosphorylation
MZO21_RS09540	COG5001	Diguanylate cyclase
MZO21_RS09545	COG0420	3'-5' exonuclease activity
MZO21_RS09575	COG0735	belongs to the Fur family
MZO21_RS09580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MZO21_RS09600	COG0121	glutamine amidotransferase
MZO21_RS09610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MZO21_RS09615	COG0756	dUTP diphosphatase activity
MZO21_RS09625	COG2885	chlorophyll binding
MZO21_RS09630	COG0204	Acyl-transferase
MZO21_RS09640	COG0850	regulation of cytokinetic process
MZO21_RS09660	COG1280	lysine exporter protein (LysE YggA)
MZO21_RS09665	COG1674	ftsk spoiiie
MZO21_RS09665	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MZO21_RS09670	COG0492	ferredoxin-NADP+ reductase activity
MZO21_RS09690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MZO21_RS09715	COG4974	Belongs to the 'phage' integrase family
MZO21_RS09770	COG0500	methyltransferase
MZO21_RS09775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MZO21_RS09780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MZO21_RS09785	COG0456	acetyltransferase
MZO21_RS09795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MZO21_RS09805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MZO21_RS09820	COG1981	membrane
MZO21_RS09825	COG1113	amino acid transport
MZO21_RS09830	COG0251	oxidation-reduction process
MZO21_RS09860	COG2207	Transcriptional regulator
MZO21_RS09865	COG0183	Belongs to the thiolase family
MZO21_RS09870	COG1250	3-hydroxyacyl-CoA dehydrogenase
MZO21_RS09870	COG1024	Enoyl-CoA hydratase
MZO21_RS09895	COG1272	protein, Hemolysin III
MZO21_RS09900	COG0477	Major facilitator Superfamily
MZO21_RS09905	COG1408	metallophosphoesterase
MZO21_RS09910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MZO21_RS09920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MZO21_RS09950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MZO21_RS09955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MZO21_RS09960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MZO21_RS09965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MZO21_RS09970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MZO21_RS09980	COG2969	positive regulation of protein catabolic process
MZO21_RS10055	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MZO21_RS10060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MZO21_RS10070	COG0653	protein targeting
MZO21_RS10080	COG0285	dihydrofolate synthase activity
MZO21_RS10085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MZO21_RS10100	COG3083	sulfuric ester hydrolase activity
MZO21_RS10125	COG4206	TonB-dependent receptor
MZO21_RS10130	COG2096	Adenosyltransferase
MZO21_RS10145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MZO21_RS10155	COG1113	amino acid transport
MZO21_RS10160	COG0745	RESPONSE REGULATOR receiver
MZO21_RS10165	COG2205	protein histidine kinase activity
MZO21_RS10175	COG1960	acyl-CoA dehydrogenase activity
MZO21_RS10180	COG1960	acyl-CoA dehydrogenase activity
MZO21_RS10220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MZO21_RS10240	COG1215	transferase activity, transferring glycosyl groups
MZO21_RS10265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MZO21_RS10270	COG1088	dTDP-glucose 4,6-dehydratase activity
MZO21_RS10320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MZO21_RS10325	COG5002	protein histidine kinase activity
MZO21_RS10335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MZO21_RS10345	COG1704	LemA family
MZO21_RS10355	COG1862	Preprotein translocase
MZO21_RS10380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MZO21_RS10385	COG1028	Short-chain dehydrogenase reductase Sdr
MZO21_RS10425	COG2986	histidine ammonia-lyase
MZO21_RS10450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MZO21_RS10455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MZO21_RS10490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MZO21_RS10515	COG1024	Enoyl-CoA hydratase
MZO21_RS10520	COG2084	Dehydrogenase
MZO21_RS10525	COG3622	Belongs to the hyi family
MZO21_RS10540	COG0004	ammonium transporteR
MZO21_RS10565	COG2814	Major facilitator Superfamily
MZO21_RS10570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MZO21_RS10580	COG3293	Transposase
MZO21_RS10585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MZO21_RS10590	COG0084	hydrolase, TatD family'
MZO21_RS10605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MZO21_RS10630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MZO21_RS10635	COG0280	phosphate acetyltransferase
MZO21_RS10635	COG0857	belongs to the CobB CobQ family
MZO21_RS10645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MZO21_RS10645	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MZO21_RS10655	COG0740	serine-type endopeptidase activity
MZO21_RS10665	COG4771	TonB-dependent receptor
MZO21_RS10670	COG4774	siderophore transport
MZO21_RS10685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MZO21_RS10695	COG2813	Specifically methylates the guanine in position
MZO21_RS10695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MZO21_RS10750	COG0583	DNA-binding transcription factor activity
MZO21_RS10785	COG0753	catalase activity
MZO21_RS10800	COG0446	pyridine nucleotide-disulphide oxidoreductase
MZO21_RS10805	COG3384	dioxygenase
MZO21_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
MZO21_RS10825	COG4638	Rieske (2fe-2S)
MZO21_RS10830	COG0583	DNA-binding transcription factor activity
MZO21_RS10850	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MZO21_RS10855	COG3971	2-oxopent-4-enoate hydratase activity
MZO21_RS10860	COG0546	phosphoglycolate phosphatase activity
MZO21_RS10865	COG0564	pseudouridine synthase activity
MZO21_RS10870	COG1530	ribonuclease E activity
MZO21_RS10875	COG0318	PFAM AMP-dependent synthetase and ligase
MZO21_RS10900	COG1983	PspC domain protein
MZO21_RS10905	COG0517	IMP dehydrogenase activity
MZO21_RS10910	COG0752	glycyl-tRNA synthetase alpha subunit
MZO21_RS10915	COG0751	glycine-tRNA ligase activity
MZO21_RS10945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MZO21_RS10970	COG0493	'glutamate synthase
MZO21_RS10970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MZO21_RS10980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MZO21_RS10985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MZO21_RS11000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MZO21_RS11010	COG0644	oxidoreductase
MZO21_RS11010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
MZO21_RS11015	COG0425	Belongs to the sulfur carrier protein TusA family
MZO21_RS11020	COG4535	Mg2 and Co2 transporter CorC
MZO21_RS11025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MZO21_RS11035	COG1278	Cold shock
MZO21_RS11040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MZO21_RS11050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MZO21_RS11060	COG2841	Protein conserved in bacteria
MZO21_RS11065	COG2841	Protein conserved in bacteria
MZO21_RS11080	COG1185	polyribonucleotide nucleotidyltransferase activity
MZO21_RS11090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MZO21_RS11095	COG1074	ATP-dependent DNA helicase activity
MZO21_RS11100	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MZO21_RS11130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MZO21_RS11140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MZO21_RS11155	COG2111	Na H antiporter
MZO21_RS11155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MZO21_RS11160	COG1006	Multisubunit Na H antiporter MnhC subunit
MZO21_RS11165	COG0651	ATP synthesis coupled electron transport
MZO21_RS11170	COG1863	multisubunit Na H antiporter MnhE subunit
MZO21_RS11175	COG2212	antiporter activity
MZO21_RS11180	COG1320	monovalent cation:proton antiporter activity
MZO21_RS11185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MZO21_RS11195	COG0195	Participates in both transcription termination and antitermination
MZO21_RS11200	COG0779	Required for maturation of 30S ribosomal subunits
MZO21_RS11255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MZO21_RS11260	COG0237	dephospho-CoA kinase activity
MZO21_RS11270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MZO21_RS11275	COG3123	guanosine phosphorylase activity
MZO21_RS11280	COG0497	DNA recombination
MZO21_RS11290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MZO21_RS11305	COG1132	(ABC) transporter
MZO21_RS11310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MZO21_RS11350	COG3328	transposase activity
MZO21_RS11360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MZO21_RS11380	COG0326	Molecular chaperone. Has ATPase activity
MZO21_RS11395	COG2056	Na+-H+ antiporter family
MZO21_RS11410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MZO21_RS11415	COG0085	RNA polymerase activity
MZO21_RS11420	COG0222	ribosome binding
MZO21_RS11425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MZO21_RS11430	COG0081	regulation of translation
MZO21_RS11445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MZO21_RS11520	COG0181	hydroxymethylbilane synthase activity
MZO21_RS11530	COG3275	phosphorelay sensor kinase activity
MZO21_RS11545	COG0704	Plays a role in the regulation of phosphate uptake
MZO21_RS11575	COG0494	nUDIX hydrolase
MZO21_RS11580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MZO21_RS11585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MZO21_RS11590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MZO21_RS11600	COG0772	Belongs to the SEDS family
MZO21_RS11625	COG4974	Belongs to the 'phage' integrase family
MZO21_RS11640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MZO21_RS11650	COG2197	response regulator
MZO21_RS11665	COG0793	Belongs to the peptidase S41A family
MZO21_RS11670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MZO21_RS11675	COG0795	lipopolysaccharide-transporting ATPase activity
MZO21_RS11680	COG0795	lipopolysaccharide-transporting ATPase activity
MZO21_RS11700	COG0586	Pfam SNARE associated Golgi protein
MZO21_RS11715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MZO21_RS11715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MZO21_RS11725	COG0004	ammonium transporteR
MZO21_RS11730	COG0347	Belongs to the P(II) protein family
MZO21_RS11740	COG0606	chelatase, subunit chli
MZO21_RS11755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MZO21_RS11770	COG0318	PFAM AMP-dependent synthetase and ligase
MZO21_RS11780	COG0477	Major facilitator Superfamily
MZO21_RS11785	COG2860	membrane
MZO21_RS11795	COG1253	flavin adenine dinucleotide binding
MZO21_RS11810	COG2814	Major facilitator Superfamily
MZO21_RS11820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MZO21_RS11885	COG4771	TonB-dependent receptor
MZO21_RS11905	COG0758	DNA mediated transformation
MZO21_RS11915	COG0697	spore germination
MZO21_RS11925	COG0386	Belongs to the glutathione peroxidase family
MZO21_RS11955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MZO21_RS11995	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MZO21_RS12005	COG1121	(ABC) transporter
MZO21_RS12010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MZO21_RS12015	COG1280	lysine exporter protein (LysE YggA)
MZO21_RS12020	COG2837	iron assimilation
MZO21_RS12025	COG0281	malic enzyme
MZO21_RS12070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MZO21_RS12070	COG0519	Catalyzes the synthesis of GMP from XMP
MZO21_RS12080	COG2259	Doxx family
MZO21_RS12085	COG0586	Pfam SNARE associated Golgi protein
MZO21_RS12110	COG0271	Belongs to the BolA IbaG family
MZO21_RS12145	COG3756	Protein conserved in bacteria
MZO21_RS12245	COG4372	Transposase
MZO21_RS12270	COG4372	Transposase
MZO21_RS12305	COG3550	peptidyl-serine autophosphorylation
MZO21_RS12310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MZO21_RS12340	COG2801	Transposase and inactivated derivatives
MZO21_RS12380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MZO21_RS12385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MZO21_RS12390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MZO21_RS12400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MZO21_RS12405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MZO21_RS12410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MZO21_RS12425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MZO21_RS12435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MZO21_RS12445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MZO21_RS12450	COG0438	transferase activity, transferring glycosyl groups
MZO21_RS12455	COG0438	transferase activity, transferring glycosyl groups
MZO21_RS12460	COG0438	transferase activity, transferring glycosyl groups
MZO21_RS12470	COG0110	maltose O-acetyltransferase activity
MZO21_RS12485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MZO21_RS12490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MZO21_RS12525	COG2233	PERMEase
MZO21_RS12530	COG0583	DNA-binding transcription factor activity
MZO21_RS12555	COG0129	dihydroxy-acid dehydratase activity
MZO21_RS12570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MZO21_RS12570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MZO21_RS12580	COG0733	neurotransmitter:sodium symporter activity
MZO21_RS12585	COG1012	belongs to the aldehyde dehydrogenase family
MZO21_RS12620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MZO21_RS12630	COG0583	DNA-binding transcription factor activity
MZO21_RS12655	COG2951	lytic endotransglycosylase activity
MZO21_RS12660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MZO21_RS12675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MZO21_RS12680	COG3385	transposase activity
MZO21_RS12685	COG2388	GCN5-related N-acetyl-transferase
MZO21_RS12690	COG2388	GCN5-related N-acetyl-transferase
MZO21_RS12695	COG2814	Major facilitator Superfamily
MZO21_RS12700	COG0861	Integral membrane protein TerC family
MZO21_RS12710	COG0402	S-adenosylhomocysteine deaminase activity
MZO21_RS12725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MZO21_RS12750	COG0706	membrane insertase activity
MZO21_RS12755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MZO21_RS12810	COG1525	nuclease
MZO21_RS12860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MZO21_RS12975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MZO21_RS13010	COG1660	Displays ATPase and GTPase activities
MZO21_RS13060	COG4372	Transposase
MZO21_RS13075	COG0789	Transcriptional regulator
MZO21_RS13160	COG3173	Aminoglycoside phosphotransferase
MZO21_RS13165	COG0488	(ABC) transporter
MZO21_RS13170	COG2963	transposase activity
MZO21_RS13180	COG4372	Transposase
MZO21_RS13195	COG2801	Transposase and inactivated derivatives
MZO21_RS13205	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MZO21_RS13210	COG3657	addiction module killer protein
MZO21_RS13220	COG0745	RESPONSE REGULATOR receiver
MZO21_RS13225	COG5002	protein histidine kinase activity
MZO21_RS13235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MZO21_RS13260	COG3077	Addiction module antitoxin, RelB DinJ family
MZO21_RS13275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MZO21_RS13300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MZO21_RS13320	COG4372	Transposase
MZO21_RS13435	COG0659	secondary active sulfate transmembrane transporter activity
MZO21_RS13440	COG0589	response to stress
MZO21_RS13460	COG1595	DNA-templated transcription, initiation
MZO21_RS13465	COG0785	Cytochrome C biogenesis protein
MZO21_RS13475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MZO21_RS13490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MZO21_RS13510	COG2226	methyltransferase
MZO21_RS13520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MZO21_RS13795	COG1192	Involved in chromosome partitioning
MZO21_RS13800	COG1475	DNA binding
MZO21_RS13960	COG4974	Belongs to the 'phage' integrase family
MZO21_RS14110	COG3293	Transposase
MZO21_RS14150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MZO21_RS14185	COG2826	transposase and inactivated derivatives, IS30 family
MZO21_RS14195	COG2826	transposase and inactivated derivatives, IS30 family
MZO21_RS14365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MZO21_RS14445	COG1192	Involved in chromosome partitioning
MZO21_RS14450	COG1475	DNA binding
MZO21_RS14495	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MZO21_RS14500	COG3657	addiction module killer protein
MZO21_RS14515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MZO21_RS14530	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
MZO21_RS14535	COG0583	DNA-binding transcription factor activity
MZO21_RS14540	COG2249	NAD(P)H dehydrogenase (quinone) activity
MZO21_RS14545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MZO21_RS14560	COG3077	Addiction module antitoxin, RelB DinJ family
MZO21_RS14575	COG3077	Addiction module antitoxin, RelB DinJ family
MZO21_RS14580	COG2188	Transcriptional regulator
MZO21_RS14595	COG2801	Transposase and inactivated derivatives
MZO21_RS14615	COG0579	oxidoreductase
MZO21_RS14660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MZO21_RS14730	COG0668	transmembrane transport
MZO21_RS14735	COG2801	Transposase and inactivated derivatives
MZO21_RS14785	COG1454	alcohol dehydrogenase
MZO21_RS14790	COG2610	gluconate transmembrane transporter activity
MZO21_RS14805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MZO21_RS14810	COG0589	response to stress
MZO21_RS14815	COG0659	secondary active sulfate transmembrane transporter activity
MZO21_RS14885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MZO21_RS14940	COG2963	transposase activity
MZO21_RS15000	COG1373	ATPase (AAA superfamily