locus-tag	class	description
E3H47_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3H47_RS00010	COG0592	DNA-directed DNA polymerase activity
E3H47_RS00020	COG0187	DNA topoisomerase II activity
E3H47_RS00025	COG1063	alcohol dehydrogenase
E3H47_RS00035	COG0488	(ABC) transporter
E3H47_RS00060	COG0596	Alpha beta hydrolase
E3H47_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E3H47_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3H47_RS00085	COG1047	Peptidyl-prolyl cis-trans
E3H47_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3H47_RS00095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3H47_RS00100	COG0196	riboflavin kinase activity
E3H47_RS00120	COG1116	anion transmembrane transporter activity
E3H47_RS00125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3H47_RS00130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3H47_RS00135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3H47_RS00140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3H47_RS00145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3H47_RS00145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3H47_RS00160	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS00165	COG0546	phosphoglycolate phosphatase activity
E3H47_RS00180	COG1309	transcriptional regulator
E3H47_RS00190	COG0543	2 iron, 2 sulfur cluster binding
E3H47_RS00200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3H47_RS00260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3H47_RS00305	COG0438	transferase activity, transferring glycosyl groups
E3H47_RS00310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3H47_RS00320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3H47_RS00330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3H47_RS00345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3H47_RS00350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3H47_RS00365	COG0271	Belongs to the BolA IbaG family
E3H47_RS00380	COG0586	Pfam SNARE associated Golgi protein
E3H47_RS00385	COG0519	Catalyzes the synthesis of GMP from XMP
E3H47_RS00385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3H47_RS00415	COG0281	malic enzyme
E3H47_RS00480	COG2837	iron assimilation
E3H47_RS00485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3H47_RS00490	COG1121	(ABC) transporter
E3H47_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_RS00565	COG0386	Belongs to the glutathione peroxidase family
E3H47_RS00580	COG0697	spore germination
E3H47_RS00590	COG0758	DNA mediated transformation
E3H47_RS00595	COG1652	LysM domain
E3H47_RS00640	COG2814	Major facilitator Superfamily
E3H47_RS00650	COG2814	Major facilitator Superfamily
E3H47_RS00670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3H47_RS00695	COG1253	flavin adenine dinucleotide binding
E3H47_RS00705	COG2860	membrane
E3H47_RS00710	COG0477	Major facilitator Superfamily
E3H47_RS00720	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_RS00735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3H47_RS00750	COG0606	chelatase, subunit chli
E3H47_RS00760	COG0347	Belongs to the P(II) protein family
E3H47_RS00765	COG0004	ammonium transporteR
E3H47_RS00775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3H47_RS00775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3H47_RS00805	COG0795	lipopolysaccharide-transporting ATPase activity
E3H47_RS00810	COG0795	lipopolysaccharide-transporting ATPase activity
E3H47_RS00815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E3H47_RS00820	COG0793	Belongs to the peptidase S41A family
E3H47_RS00835	COG2197	response regulator
E3H47_RS00845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3H47_RS00860	COG4974	Belongs to the 'phage' integrase family
E3H47_RS00885	COG0772	Belongs to the SEDS family
E3H47_RS00895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3H47_RS00900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3H47_RS00910	COG0494	nUDIX hydrolase
E3H47_RS00945	COG3275	phosphorelay sensor kinase activity
E3H47_RS00955	COG0181	hydroxymethylbilane synthase activity
E3H47_RS01000	COG1716	ATPase activity
E3H47_RS01005	COG0546	phosphoglycolate phosphatase activity
E3H47_RS01075	COG0085	RNA polymerase activity
E3H47_RS01080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3H47_RS01095	COG2056	Na+-H+ antiporter family
E3H47_RS01105	COG0326	Molecular chaperone. Has ATPase activity
E3H47_RS01125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E3H47_RS01155	COG0322	excinuclease ABC activity
E3H47_RS01165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3H47_RS01170	COG1132	(ABC) transporter
E3H47_RS01200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3H47_RS01210	COG0497	DNA recombination
E3H47_RS01220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3H47_RS01225	COG0697	spore germination
E3H47_RS01230	COG0237	dephospho-CoA kinase activity
E3H47_RS01275	COG0779	Required for maturation of 30S ribosomal subunits
E3H47_RS01280	COG0195	Participates in both transcription termination and antitermination
E3H47_RS01295	COG1320	monovalent cation:proton antiporter activity
E3H47_RS01300	COG2212	antiporter activity
E3H47_RS01305	COG1863	multisubunit Na H antiporter MnhE subunit
E3H47_RS01310	COG0651	ATP synthesis coupled electron transport
E3H47_RS01315	COG1006	Multisubunit Na H antiporter MnhC subunit
E3H47_RS01320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3H47_RS01320	COG2111	Na H antiporter
E3H47_RS01335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3H47_RS01340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3H47_RS01370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3H47_RS01375	COG1074	ATP-dependent DNA helicase activity
E3H47_RS01380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3H47_RS01390	COG1185	polyribonucleotide nucleotidyltransferase activity
E3H47_RS01395	COG0598	Magnesium transport protein CorA
E3H47_RS01405	COG0484	heat shock protein binding
E3H47_RS01415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E3H47_RS01425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3H47_RS01445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3H47_RS01450	COG4535	Mg2 and Co2 transporter CorC
E3H47_RS01460	COG0425	Belongs to the sulfur carrier protein TusA family
E3H47_RS01470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3H47_RS01470	COG0644	oxidoreductase
E3H47_RS01480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3H47_RS01495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3H47_RS01505	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E3H47_RS01515	COG0493	'glutamate synthase
E3H47_RS01515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3H47_RS01530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3H47_RS01540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3H47_RS01545	COG0534	Mate efflux family protein
E3H47_RS01555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3H47_RS01560	COG1280	lysine exporter protein (LysE YggA)
E3H47_RS01585	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_RS01590	COG1530	ribonuclease E activity
E3H47_RS01605	COG0546	phosphoglycolate phosphatase activity
E3H47_RS01610	COG3971	2-oxopent-4-enoate hydratase activity
E3H47_RS01615	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E3H47_RS01645	COG0583	DNA-binding transcription factor activity
E3H47_RS01650	COG4638	Rieske (2fe-2S)
E3H47_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS01670	COG3384	dioxygenase
E3H47_RS01675	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_RS01700	COG0753	catalase activity
E3H47_RS01710	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS01725	COG0494	nUDIX hydrolase
E3H47_RS01735	COG0583	DNA-binding transcription factor activity
E3H47_RS01740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3H47_RS01755	COG0473	3-isopropylmalate dehydrogenase activity
E3H47_RS01810	COG1560	Kdo2-lipid A biosynthetic process
E3H47_RS01820	COG0488	(ABC) transporter
E3H47_RS01825	COG2900	Belongs to the SlyX family
E3H47_RS01855	COG1929	Belongs to the glycerate kinase type-1 family
E3H47_RS01860	COG0210	DNA helicase
E3H47_RS01865	COG0724	RNA recognition motif
E3H47_RS01880	COG4651	solute:proton antiporter activity
E3H47_RS01880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3H47_RS01905	COG0788	formyltetrahydrofolate deformylase activity
E3H47_RS01940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3H47_RS01960	COG0500	methyltransferase
E3H47_RS02025	COG2813	Specifically methylates the guanine in position
E3H47_RS02025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_RS02030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_RS02035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3H47_RS02045	COG4774	siderophore transport
E3H47_RS02055	COG0740	serine-type endopeptidase activity
E3H47_RS02070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3H47_RS02070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3H47_RS02080	COG0280	phosphate acetyltransferase
E3H47_RS02080	COG0857	belongs to the CobB CobQ family
E3H47_RS02085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3H47_RS02100	COG2267	carboxylic ester hydrolase activity
E3H47_RS02115	COG0793	Belongs to the peptidase S41A family
E3H47_RS02150	COG1426	Protein conserved in bacteria
E3H47_RS02160	COG0124	histidyl-tRNA synthetase
E3H47_RS02170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3H47_RS02195	COG1862	Preprotein translocase
E3H47_RS02205	COG1704	LemA family
E3H47_RS02230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3H47_RS02245	COG0726	polysaccharide deacetylase
E3H47_RS02265	COG1091	dTDP-4-dehydrorhamnose reductase activity
E3H47_RS02280	COG1215	transferase activity, transferring glycosyl groups
E3H47_RS02340	COG0577	efflux transmembrane transporter activity
E3H47_RS02340	COG1136	(ABC) transporter
E3H47_RS02345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3H47_RS02370	COG0028	Belongs to the TPP enzyme family
E3H47_RS02390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E3H47_RS02405	COG0084	hydrolase, TatD family'
E3H47_RS02415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3H47_RS02420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3H47_RS02430	COG2814	Major facilitator Superfamily
E3H47_RS02435	COG0697	spore germination
E3H47_RS02460	COG3622	Belongs to the hyi family
E3H47_RS02465	COG2084	Dehydrogenase
E3H47_RS02470	COG1024	Enoyl-CoA hydratase
E3H47_RS02475	COG0784	Response regulator, receiver
E3H47_RS02475	COG2205	protein histidine kinase activity
E3H47_RS02475	COG5002	protein histidine kinase activity
E3H47_RS02495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3H47_RS02505	COG3956	TIGRFAM MazG family protein
E3H47_RS02510	COG1555	photosystem II stabilization
E3H47_RS02515	COG0617	tRNA 3'-terminal CCA addition
E3H47_RS02520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3H47_RS02530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3H47_RS02535	COG1660	Displays ATPase and GTPase activities
E3H47_RS02540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3H47_RS02545	COG3028	Belongs to the UPF0307 family
E3H47_RS02560	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_RS02580	COG0625	glutathione transferase activity
E3H47_RS02585	COG1238	metal cluster binding
E3H47_RS02625	COG0072	phenylalanine-tRNA ligase activity
E3H47_RS02650	COG0248	Ppx GppA phosphatase
E3H47_RS02660	COG0037	tRNA processing
E3H47_RS02700	COG1764	response to oxidative stress
E3H47_RS02705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3H47_RS02755	COG2969	positive regulation of protein catabolic process
E3H47_RS02760	COG0625	glutathione transferase activity
E3H47_RS02765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3H47_RS02780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3H47_RS02785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3H47_RS02790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3H47_RS02800	COG1346	cytolysis
E3H47_RS02810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3H47_RS02820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3H47_RS02825	COG1408	metallophosphoesterase
E3H47_RS02830	COG0477	Major facilitator Superfamily
E3H47_RS02835	COG1272	protein, Hemolysin III
E3H47_RS02845	COG4667	esterase of the alpha-beta hydrolase superfamily
E3H47_RS02855	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3H47_RS02855	COG1024	Enoyl-CoA hydratase
E3H47_RS02860	COG0183	Belongs to the thiolase family
E3H47_RS02865	COG2207	Transcriptional regulator
E3H47_RS02875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_RS02885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3H47_RS02895	COG1289	transmembrane transporter activity
E3H47_RS02900	COG2814	Major facilitator Superfamily
E3H47_RS02915	COG0786	glutamate:sodium symporter activity
E3H47_RS02920	COG1115	amino acid carrier protein
E3H47_RS02925	COG2059	Chromate
E3H47_RS02930	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3H47_RS02950	COG4770	biotin carboxylase activity
E3H47_RS02955	COG1024	Enoyl-CoA hydratase
E3H47_RS02960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3H47_RS02965	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS02970	COG1309	transcriptional regulator
E3H47_RS02975	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_RS02980	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E3H47_RS03005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3H47_RS03015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3H47_RS03020	COG1077	Cell shape determining protein MreB Mrl
E3H47_RS03025	COG1792	Involved in formation and maintenance of cell shape
E3H47_RS03030	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3H47_RS03035	COG0424	maF-like protein
E3H47_RS03045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3H47_RS03055	COG0560	Phosphoserine phosphatase
E3H47_RS03075	COG0642	Histidine kinase
E3H47_RS03085	COG2194	sulfuric ester hydrolase activity
E3H47_RS03095	COG1113	amino acid transport
E3H47_RS03100	COG2828	Protein conserved in bacteria
E3H47_RS03105	COG2824	Alkylphosphonate utilization operon protein PhnA
E3H47_RS03110	COG0142	geranyltranstransferase activity
E3H47_RS03140	COG1484	DNA-dependent DNA replication
E3H47_RS03190	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3H47_RS03215	COG1309	transcriptional regulator
E3H47_RS03235	COG0004	ammonium transporteR
E3H47_RS03240	COG1126	abc transporter atp-binding protein
E3H47_RS03245	COG0765	amino acid transport
E3H47_RS03250	COG0765	amino acid transport
E3H47_RS03280	COG0525	valine-tRNA ligase activity
E3H47_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS03300	COG0393	Putative heavy-metal-binding
E3H47_RS03305	COG1538	Outer membrane efflux protein
E3H47_RS03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3H47_RS03320	COG0671	phosphoesterase, PA-phosphatase related
E3H47_RS03335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3H47_RS03340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3H47_RS03345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E3H47_RS03370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_RS03380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3H47_RS03380	COG1648	precorrin-2 dehydrogenase activity
E3H47_RS03385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3H47_RS03390	COG0531	amino acid
E3H47_RS03405	COG0321	lipoyl(octanoyl) transferase activity
E3H47_RS03430	COG0586	Pfam SNARE associated Golgi protein
E3H47_RS03450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3H47_RS03470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3H47_RS03500	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E3H47_RS03515	COG0358	DNA primase activity
E3H47_RS03525	COG0564	pseudouridine synthase activity
E3H47_RS03545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3H47_RS03575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3H47_RS03575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3H47_RS03595	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3H47_RS03600	COG1053	succinate dehydrogenase
E3H47_RS03620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3H47_RS03630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3H47_RS03640	COG2354	Protein conserved in bacteria
E3H47_RS03645	COG2321	neutral zinc metallopeptidase
E3H47_RS03670	COG0110	maltose O-acetyltransferase activity
E3H47_RS03680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3H47_RS03685	COG0505	Belongs to the CarA family
E3H47_RS03710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3H47_RS03715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3H47_RS03750	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E3H47_RS03755	COG1597	lipid kinase activity
E3H47_RS03770	COG0459	protein refolding
E3H47_RS03785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3H47_RS03790	COG2239	Acts as a magnesium transporter
E3H47_RS03800	COG0501	Belongs to the peptidase M48B family
E3H47_RS03805	COG1196	nuclear chromosome segregation
E3H47_RS03805	COG0739	heme binding
E3H47_RS03805	COG0741	lytic transglycosylase activity
E3H47_RS03810	COG0037	tRNA processing
E3H47_RS03820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3H47_RS03825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3H47_RS03855	COG1215	transferase activity, transferring glycosyl groups
E3H47_RS03880	COG0439	Biotin carboxylase
E3H47_RS03895	COG0864	Transcriptional regulator
E3H47_RS03905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3H47_RS03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3H47_RS03935	COG2814	Major facilitator Superfamily
E3H47_RS03950	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3H47_RS03960	COG0154	amidase activity
E3H47_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS04000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_RS04115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3H47_RS04120	COG3739	integral membrane protein
E3H47_RS04135	COG3706	GGDEF domain
E3H47_RS04140	COG0302	gtp cyclohydrolase
E3H47_RS04155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3H47_RS04160	COG0512	Glutamine amidotransferase of anthranilate synthase
E3H47_RS04165	COG0174	glutamine synthetase
E3H47_RS04180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E3H47_RS04215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3H47_RS04220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3H47_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3H47_RS04240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3H47_RS04250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3H47_RS04255	COG0415	Belongs to the DNA photolyase family
E3H47_RS04265	COG1252	NADH dehydrogenase
E3H47_RS04270	COG1686	Belongs to the peptidase S11 family
E3H47_RS04310	COG1823	symporter activity
E3H47_RS04315	COG0612	Peptidase, M16
E3H47_RS04335	COG3025	triphosphatase activity
E3H47_RS04345	COG0352	thiamine-phosphate diphosphorylase activity
E3H47_RS04400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3H47_RS04405	COG0076	glutamate decarboxylase activity
E3H47_RS04410	COG1522	sequence-specific DNA binding
E3H47_RS04415	COG3961	Belongs to the TPP enzyme family
E3H47_RS04420	COG1113	amino acid transport
E3H47_RS04430	COG0573	inorganic phosphate transmembrane transporter activity
E3H47_RS04440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3H47_RS04450	COG0616	signal peptide processing
E3H47_RS04470	COG2915	High frequency lysogenization protein hflD homolog
E3H47_RS04485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3H47_RS04490	COG1686	Belongs to the peptidase S11 family
E3H47_RS04515	COG0583	DNA-binding transcription factor activity
E3H47_RS04520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3H47_RS04525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3H47_RS04530	COG1067	ATP-dependent peptidase activity
E3H47_RS04575	COG1966	Carbon starvation protein
E3H47_RS04580	COG2879	small protein
E3H47_RS04585	COG0714	Associated with various cellular activities
E3H47_RS04680	COG1396	sequence-specific DNA binding
E3H47_RS04885	COG3179	chitinase
E3H47_RS04955	COG3179	chitinase
E3H47_RS05000	COG0659	secondary active sulfate transmembrane transporter activity
E3H47_RS05010	COG2252	PERMEase
E3H47_RS05015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3H47_RS05025	COG1215	transferase activity, transferring glycosyl groups
E3H47_RS05035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3H47_RS05045	COG0527	aspartate kinase activity
E3H47_RS05055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3H47_RS05070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3H47_RS05085	COG0667	Aldo Keto reductase
E3H47_RS05095	COG1765	OsmC-like protein
E3H47_RS05115	COG0540	Belongs to the ATCase OTCase family
E3H47_RS05125	COG2885	chlorophyll binding
E3H47_RS05125	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3H47_RS05140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_RS05140	COG2226	methyltransferase
E3H47_RS05140	COG0596	Alpha beta hydrolase
E3H47_RS05145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3H47_RS05180	COG1278	Cold shock
E3H47_RS05185	COG0513	Belongs to the DEAD box helicase family
E3H47_RS05195	COG0778	Nitroreductase
E3H47_RS05225	COG1286	toxin biosynthetic process
E3H47_RS05250	COG4783	chaperone-mediated protein folding
E3H47_RS05255	COG1610	YqeY-like protein
E3H47_RS05285	COG2815	serine threonine protein kinase
E3H47_RS05285	COG0515	serine threonine protein kinase
E3H47_RS05365	COG2308	Evidence 4 Homologs of previously reported genes of
E3H47_RS05385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3H47_RS05390	COG0305	Participates in initiation and elongation during chromosome replication
E3H47_RS05400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3H47_RS05405	COG0360	Binds together with S18 to 16S ribosomal RNA
E3H47_RS05415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3H47_RS05420	COG1845	cytochrome c oxidase, subunit III
E3H47_RS05425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3H47_RS05430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3H47_RS05455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E3H47_RS05475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3H47_RS05490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3H47_RS05495	COG2890	protein-(glutamine-N5) methyltransferase activity
E3H47_RS05510	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS05515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3H47_RS05535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3H47_RS05555	COG0729	surface antigen
E3H47_RS05560	COG2911	Protein conserved in bacteria
E3H47_RS05605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3H47_RS05610	COG4605	iron ion homeostasis
E3H47_RS05615	COG4604	ABC transporter, ATP-binding protein
E3H47_RS05620	COG4607	ABC-type enterochelin transport system periplasmic component
E3H47_RS05625	COG2814	Major facilitator Superfamily
E3H47_RS05630	COG0786	glutamate:sodium symporter activity
E3H47_RS05635	COG0583	DNA-binding transcription factor activity
E3H47_RS05640	COG2707	UPF0756 membrane protein
E3H47_RS05655	COG0564	pseudouridine synthase activity
E3H47_RS05660	COG0802	atpase or kinase
E3H47_RS05665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3H47_RS05675	COG1923	regulation of RNA biosynthetic process
E3H47_RS05680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3H47_RS05695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E3H47_RS05705	COG1192	Involved in chromosome partitioning
E3H47_RS05710	COG1475	DNA binding
E3H47_RS05715	COG0811	peptide transport
E3H47_RS05725	COG1132	(ABC) transporter
E3H47_RS05730	COG1663	tetraacyldisaccharide 4'-kinase activity
E3H47_RS05750	COG0084	hydrolase, TatD family'
E3H47_RS05760	COG2165	general secretion pathway protein
E3H47_RS05775	COG3156	type II secretion system protein K
E3H47_RS05815	COG0776	regulation of translation
E3H47_RS05835	COG1396	sequence-specific DNA binding
E3H47_RS05845	COG2431	L-lysine efflux transmembrane transporter activity
E3H47_RS05860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3H47_RS05870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3H47_RS05885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3H47_RS05890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3H47_RS05895	COG0022	dehydrogenase e1 component
E3H47_RS05900	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3H47_RS05905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3H47_RS05910	COG1063	alcohol dehydrogenase
E3H47_RS05945	COG1114	Component of the transport system for branched-chain amino acids
E3H47_RS05950	COG0024	Methionine aminopeptidase
E3H47_RS05955	COG0583	DNA-binding transcription factor activity
E3H47_RS05965	COG0583	DNA-binding transcription factor activity
E3H47_RS05970	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS05985	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3H47_RS05995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3H47_RS06010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3H47_RS06015	COG0569	domain protein
E3H47_RS06020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3H47_RS06025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3H47_RS06035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3H47_RS06045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3H47_RS06050	COG0542	response to heat
E3H47_RS06080	COG0372	Belongs to the citrate synthase family
E3H47_RS06090	COG2204	response regulator
E3H47_RS06095	COG3852	Histidine kinase
E3H47_RS06110	COG0233	cytoplasmic translational termination
E3H47_RS06115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3H47_RS06120	COG0575	Belongs to the CDS family
E3H47_RS06135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3H47_RS06155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3H47_RS06170	COG2137	regulation of response to DNA damage stimulus
E3H47_RS06175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3H47_RS06180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3H47_RS06185	COG1011	Hydrolase
E3H47_RS06200	COG0268	Binds directly to 16S ribosomal RNA
E3H47_RS06205	COG0702	epimerase
E3H47_RS06210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3H47_RS06225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3H47_RS06255	COG0316	Belongs to the HesB IscA family
E3H47_RS06260	COG0822	iron-sulfur transferase activity
E3H47_RS06285	COG0776	regulation of translation
E3H47_RS06290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3H47_RS06300	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS06305	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS06330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3H47_RS06365	COG1278	Cold shock
E3H47_RS06370	COG2323	membrane
E3H47_RS06375	COG0671	phosphoesterase, PA-phosphatase related
E3H47_RS06385	COG2819	hydrolase of the alpha beta superfamily
E3H47_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS06460	COG0439	Biotin carboxylase
E3H47_RS06470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3H47_RS06495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3H47_RS06555	COG1271	oxidase subunit
E3H47_RS06560	COG1294	oxidase, subunit
E3H47_RS06575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3H47_RS06620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3H47_RS06625	COG1027	Aspartate ammonia-lyase
E3H47_RS06635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3H47_RS06645	COG1448	Aminotransferase
E3H47_RS06650	COG1113	amino acid transport
E3H47_RS06665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3H47_RS06670	COG2814	Major facilitator Superfamily
E3H47_RS06675	COG0509	glycine decarboxylation via glycine cleavage system
E3H47_RS06690	COG1132	(ABC) transporter
E3H47_RS06695	COG2203	Gaf domain
E3H47_RS06695	COG2199	diguanylate cyclase activity
E3H47_RS06710	COG3706	GGDEF domain
E3H47_RS06715	COG2801	Transposase and inactivated derivatives
E3H47_RS06730	COG0668	transmembrane transport
E3H47_RS06735	COG3122	Protein conserved in bacteria
E3H47_RS06755	COG0640	Transcriptional regulator
E3H47_RS06760	COG0783	Belongs to the Dps family
E3H47_RS06785	COG0235	Class ii aldolase
E3H47_RS06795	COG1024	Enoyl-CoA hydratase
E3H47_RS06815	COG3781	membrane
E3H47_RS06825	COG2985	domain, Protein
E3H47_RS06860	COG0583	DNA-binding transcription factor activity
E3H47_RS06905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3H47_RS06910	COG0210	DNA helicase
E3H47_RS06945	COG0477	Major facilitator Superfamily
E3H47_RS06950	COG1024	Enoyl-CoA hydratase
E3H47_RS06955	COG1024	Enoyl-CoA hydratase
E3H47_RS06960	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS06965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3H47_RS06980	COG0583	DNA-binding transcription factor activity
E3H47_RS06990	COG3327	negative regulation of DNA-templated transcription, initiation
E3H47_RS06995	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E3H47_RS07000	COG1024	Enoyl-CoA hydratase
E3H47_RS07005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3H47_RS07010	COG2151	metal-sulfur cluster biosynthetic enzyme
E3H47_RS07015	COG3396	Phenylacetate-CoA oxygenase
E3H47_RS07020	COG3460	Phenylacetate-CoA oxygenase
E3H47_RS07025	COG3396	Phenylacetate-CoA oxygenase
E3H47_RS07030	COG2030	dehydratase
E3H47_RS07030	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_RS07040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3H47_RS07045	COG4149	molybdate abc transporter
E3H47_RS07050	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3H47_RS07055	COG0303	'Molybdopterin
E3H47_RS07060	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3H47_RS07060	COG0315	cyclic pyranopterin monophosphate synthase activity
E3H47_RS07065	COG0314	molybdopterin synthase activity
E3H47_RS07075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3H47_RS07085	COG0243	molybdopterin cofactor binding
E3H47_RS07095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_RS07100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_RS07105	COG2223	nitrite transmembrane transporter activity
E3H47_RS07135	COG1570	exodeoxyribonuclease VII activity
E3H47_RS07160	COG2814	Major facilitator Superfamily
E3H47_RS07170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3H47_RS07180	COG2814	Major facilitator Superfamily
E3H47_RS07185	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS07190	COG0183	Belongs to the thiolase family
E3H47_RS07200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3H47_RS07205	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS07210	COG2814	Major facilitator Superfamily
E3H47_RS07215	COG2814	Major facilitator Superfamily
E3H47_RS07225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3H47_RS07230	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS07235	COG2814	Major facilitator Superfamily
E3H47_RS07240	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3H47_RS07240	COG0644	oxidoreductase
E3H47_RS07265	COG0583	DNA-binding transcription factor activity
E3H47_RS07270	COG1380	Effector of murein hydrolase LrgA
E3H47_RS07285	COG0406	alpha-ribazole phosphatase activity
E3H47_RS07290	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E3H47_RS07335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3H47_RS07380	COG1294	oxidase, subunit
E3H47_RS07385	COG4890	Cyd operon protein YbgT
E3H47_RS07405	COG0552	protein localization to endoplasmic reticulum
E3H47_RS07410	COG0612	Peptidase, M16
E3H47_RS07440	COG0517	IMP dehydrogenase activity
E3H47_RS07440	COG0516	GMP reductase activity
E3H47_RS07445	COG0133	tryptophan synthase activity
E3H47_RS07475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3H47_RS07500	COG0798	PFAM Bile acid sodium symporter
E3H47_RS07505	COG0640	Transcriptional regulator
E3H47_RS07550	COG1278	Cold shock
E3H47_RS07555	COG1560	Kdo2-lipid A biosynthetic process
E3H47_RS07570	COG0537	adenosine 5'-monophosphoramidase activity
E3H47_RS07595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3H47_RS07615	COG0730	response to heat
E3H47_RS07650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E3H47_RS07655	COG0148	phosphopyruvate hydratase activity
E3H47_RS07690	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_RS07690	COG1902	pentaerythritol trinitrate reductase activity
E3H47_RS07705	COG0583	DNA-binding transcription factor activity
E3H47_RS07710	COG4948	Mandelate Racemase Muconate Lactonizing
E3H47_RS07715	COG4829	muconolactone delta-isomerase
E3H47_RS07725	COG4638	Rieske (2fe-2S)
E3H47_RS07730	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E3H47_RS07735	COG0633	Ferredoxin
E3H47_RS07735	COG0543	2 iron, 2 sulfur cluster binding
E3H47_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS07750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3H47_RS07755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3H47_RS07760	COG0183	Belongs to the thiolase family
E3H47_RS07765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_RS07780	COG0477	Major facilitator Superfamily
E3H47_RS07785	COG0596	Alpha beta hydrolase
E3H47_RS07795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3H47_RS07815	COG2351	hydroxyisourate hydrolase activity
E3H47_RS07820	COG4772	TonB-dependent receptor
E3H47_RS07835	COG2084	Dehydrogenase
E3H47_RS07840	COG2233	PERMEase
E3H47_RS07845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_RS07850	COG0251	oxidation-reduction process
E3H47_RS07855	COG1335	isochorismatase
E3H47_RS07860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3H47_RS07870	COG0596	Alpha beta hydrolase
E3H47_RS07885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3H47_RS07895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3H47_RS07905	COG0697	spore germination
E3H47_RS07930	COG0424	maF-like protein
E3H47_RS07935	COG2850	peptidyl-arginine hydroxylation
E3H47_RS07940	COG0069	glutamate synthase activity
E3H47_RS07965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3H47_RS07970	COG1454	alcohol dehydrogenase
E3H47_RS07975	COG0824	Thioesterase
E3H47_RS07980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3H47_RS08005	COG0183	Belongs to the thiolase family
E3H47_RS08020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3H47_RS08030	COG3135	benzoate transporter
E3H47_RS08035	COG2076	Multidrug Resistance protein
E3H47_RS08050	COG0589	response to stress
E3H47_RS08055	COG0308	aminopeptidase N
E3H47_RS08075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3H47_RS08080	COG1454	alcohol dehydrogenase
E3H47_RS08100	COG0531	amino acid
E3H47_RS08105	COG4303	Ethanolamine ammonia lyase large subunit
E3H47_RS08110	COG4302	ethanolamine ammonia-lyase activity
E3H47_RS08115	COG0519	Catalyzes the synthesis of GMP from XMP
E3H47_RS08115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3H47_RS08120	COG2353	YceI-like domain
E3H47_RS08130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3H47_RS08165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3H47_RS08165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3H47_RS08230	COG1464	Belongs to the NlpA lipoprotein family
E3H47_RS08235	COG1464	Belongs to the NlpA lipoprotein family
E3H47_RS08240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3H47_RS08245	COG2011	ABC-type metal ion transport system permease component
E3H47_RS08250	COG0012	GTP binding
E3H47_RS08265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E3H47_RS08280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3H47_RS08285	COG0436	Aminotransferase
E3H47_RS08290	COG0386	Belongs to the glutathione peroxidase family
E3H47_RS08295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3H47_RS08300	COG0436	Aminotransferase
E3H47_RS08305	COG1464	Belongs to the NlpA lipoprotein family
E3H47_RS08310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3H47_RS08315	COG2011	ABC-type metal ion transport system permease component
E3H47_RS08350	COG0242	peptide deformylase activity
E3H47_RS08365	COG0028	Belongs to the TPP enzyme family
E3H47_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS08385	COG2267	carboxylic ester hydrolase activity
E3H47_RS08395	COG2271	Major facilitator Superfamily
E3H47_RS08400	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS08430	COG1414	Transcriptional regulator
E3H47_RS08435	COG4638	Rieske (2fe-2S)
E3H47_RS08440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E3H47_RS08445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3H47_RS08445	COG0543	2 iron, 2 sulfur cluster binding
E3H47_RS08455	COG2271	Major facilitator Superfamily
E3H47_RS08460	COG2207	Transcriptional regulator
E3H47_RS08485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3H47_RS08505	COG3052	prosthetic group binding
E3H47_RS08510	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E3H47_RS08525	COG0583	DNA-binding transcription factor activity
E3H47_RS08595	COG3706	GGDEF domain
E3H47_RS08600	COG1280	lysine exporter protein (LysE YggA)
E3H47_RS08605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_RS08645	COG0583	DNA-binding transcription factor activity
E3H47_RS08655	COG2814	Major facilitator Superfamily
E3H47_RS08665	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_RS08675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3H47_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS08725	COG4264	IucA IucC family
E3H47_RS08730	COG4264	IucA IucC family
E3H47_RS08750	COG0789	Transcriptional regulator
E3H47_RS08770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3H47_RS08780	COG4122	O-methyltransferase activity
E3H47_RS08795	COG1739	Uncharacterized protein family UPF0029
E3H47_RS08810	COG1538	Outer membrane efflux protein
E3H47_RS08815	COG1137	ATPase activity
E3H47_RS08820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3H47_RS08830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3H47_RS08835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3H47_RS08835	COG0517	IMP dehydrogenase activity
E3H47_RS08850	COG1683	Conserved Protein
E3H47_RS08860	COG1228	amidohydrolase
E3H47_RS08870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3H47_RS08895	COG0830	nickel cation binding
E3H47_RS08915	COG0804	urea catabolic process
E3H47_RS08930	COG0829	nickel cation binding
E3H47_RS08940	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_RS08945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_RS08970	COG4232	protein-disulfide reductase activity
E3H47_RS08975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3H47_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_RS08985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3H47_RS08990	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_RS09010	COG0531	amino acid
E3H47_RS09035	COG1643	Atp-dependent helicase
E3H47_RS09060	COG3634	alkyl hydroperoxide reductase activity
E3H47_RS09095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3H47_RS09105	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_RS09110	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS09115	COG1301	dicarboxylic acid transport
E3H47_RS09130	COG3139	Protein of unknown function (DUF1315)
E3H47_RS09135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3H47_RS09140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3H47_RS09150	COG0494	nUDIX hydrolase
E3H47_RS09160	COG0642	Histidine kinase
E3H47_RS09170	COG3111	PFAM Bacterial OB fold (BOF) protein
E3H47_RS09175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3H47_RS09180	COG2203	Gaf domain
E3H47_RS09180	COG2199	diguanylate cyclase activity
E3H47_RS09185	COG1720	tRNA m6t6A37 methyltransferase activity
E3H47_RS09195	COG0826	peptidase U32
E3H47_RS09200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3H47_RS09205	COG3634	alkyl hydroperoxide reductase activity
E3H47_RS09225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3H47_RS09265	COG1131	(ABC) transporter
E3H47_RS09270	COG0842	Transport permease protein
E3H47_RS09285	COG0772	Belongs to the SEDS family
E3H47_RS09290	COG2951	lytic endotransglycosylase activity
E3H47_RS09310	COG0052	Belongs to the universal ribosomal protein uS2 family
E3H47_RS09315	COG0024	Methionine aminopeptidase
E3H47_RS09330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3H47_RS09335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3H47_RS09350	COG2391	methyltransferase activity
E3H47_RS09385	COG3706	GGDEF domain
E3H47_RS09390	COG1253	flavin adenine dinucleotide binding
E3H47_RS09415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3H47_RS09445	COG3040	lipid binding
E3H47_RS09450	COG0556	nucleotide-excision repair
E3H47_RS09460	COG2199	diguanylate cyclase activity
E3H47_RS09465	COG0436	Aminotransferase
E3H47_RS09495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3H47_RS09500	COG1381	Involved in DNA repair and RecF pathway recombination
E3H47_RS09510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3H47_RS09515	COG0571	ribonuclease III activity
E3H47_RS09525	COG0681	Belongs to the peptidase S26 family
E3H47_RS09540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3H47_RS09555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3H47_RS09560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3H47_RS09565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3H47_RS09575	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E3H47_RS09580	COG4208	sulfate ABC transporter
E3H47_RS09585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E3H47_RS09590	COG0583	DNA-binding transcription factor activity
E3H47_RS09605	COG0602	queuosine metabolic process
E3H47_RS09610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E3H47_RS09620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3H47_RS09625	COG1051	belongs to the nudix hydrolase family
E3H47_RS09625	COG1056	cytidyltransferase-related domain
E3H47_RS09630	COG1024	Enoyl-CoA hydratase
E3H47_RS09640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3H47_RS09645	COG0300	oxidoreductase activity
E3H47_RS09650	COG0047	phosphoribosylformylglycinamidine synthase activity
E3H47_RS09650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3H47_RS09665	COG2255	four-way junction helicase activity
E3H47_RS09685	COG0824	Thioesterase
E3H47_RS09705	COG0823	Involved in the tonB-independent uptake of proteins
E3H47_RS09725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3H47_RS09765	COG0628	permease
E3H47_RS09770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3H47_RS09775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3H47_RS09795	COG2333	competence protein COMEC
E3H47_RS09795	COG0658	competence protein
E3H47_RS09800	COG1136	(ABC) transporter
E3H47_RS09820	COG1671	Belongs to the UPF0178 family
E3H47_RS09840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3H47_RS09870	COG1280	lysine exporter protein (LysE YggA)
E3H47_RS09890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3H47_RS09895	COG0019	diaminopimelate decarboxylase activity
E3H47_RS09905	COG1113	amino acid transport
E3H47_RS09930	COG0174	glutamine synthetase
E3H47_RS09935	COG0745	RESPONSE REGULATOR receiver
E3H47_RS09950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E3H47_RS09955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E3H47_RS09965	COG0833	amino acid
E3H47_RS09975	COG3724	N-succinylarginine dihydrolase activity
E3H47_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
E3H47_RS09985	COG3138	arginine N-succinyltransferase
E3H47_RS09990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3H47_RS09995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3H47_RS10010	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3H47_RS10010	COG1902	pentaerythritol trinitrate reductase activity
E3H47_RS10015	COG0277	FAD linked oxidase domain protein
E3H47_RS10025	COG2186	Transcriptional regulator
E3H47_RS10040	COG5001	Diguanylate cyclase
E3H47_RS10040	COG4251	negative regulation of phosphorylation
E3H47_RS10040	COG3706	GGDEF domain
E3H47_RS10040	COG2203	Gaf domain
E3H47_RS10045	COG0418	dihydroorotase activity
E3H47_RS10050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3H47_RS10065	COG0833	amino acid
E3H47_RS10085	COG4172	Belongs to the ABC transporter superfamily
E3H47_RS10090	COG4239	(ABC) transporter, permease
E3H47_RS10095	COG4174	ABC transporter (Permease)
E3H47_RS10100	COG4166	transmembrane transport
E3H47_RS10105	COG1388	LysM domain
E3H47_RS10105	COG1388	LysM domain
E3H47_RS10105	COG0741	lytic transglycosylase activity
E3H47_RS10105	COG0741	lytic transglycosylase activity
E3H47_RS10110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3H47_RS10120	COG2816	NAD+ diphosphatase activity
E3H47_RS10140	COG3107	peptidoglycan biosynthetic process
E3H47_RS10155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3H47_RS10160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3H47_RS10165	COG0006	proline dipeptidase activity
E3H47_RS10190	COG1522	sequence-specific DNA binding
E3H47_RS10210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3H47_RS10215	COG1917	Cupin 2, conserved barrel domain protein
E3H47_RS10215	COG2169	Transcriptional regulator
E3H47_RS10230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3H47_RS10240	COG2234	aminopeptidase activity
E3H47_RS10245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3H47_RS10250	COG3384	dioxygenase
E3H47_RS10260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3H47_RS10265	COG2878	Part of a membrane complex involved in electron transport
E3H47_RS10270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3H47_RS10295	COG0768	penicillin binding
E3H47_RS10300	COG0742	ribosomal rna small subunit methyltransferase
E3H47_RS10315	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS10345	COG1253	flavin adenine dinucleotide binding
E3H47_RS10355	COG4221	oxidoreductase activity
E3H47_RS10355	COG3321	synthase
E3H47_RS10355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3H47_RS10355	COG0604	alcohol dehydrogenase
E3H47_RS10360	COG0584	glycerophosphoryl diester phosphodiesterase
E3H47_RS10390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3H47_RS10395	COG1773	rubredoxin
E3H47_RS10400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3H47_RS10410	COG0583	DNA-binding transcription factor activity
E3H47_RS10430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3H47_RS10435	COG4181	ATPase activity
E3H47_RS10445	COG0288	reversible hydration of carbon dioxide
E3H47_RS10480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E3H47_RS10490	COG0306	phosphate transporter
E3H47_RS10510	COG0477	Major facilitator Superfamily
E3H47_RS10525	COG0477	Major facilitator Superfamily
E3H47_RS10555	COG1285	pathogenesis
E3H47_RS10560	COG4681	YaeQ
E3H47_RS10565	COG0523	cobalamin synthesis protein
E3H47_RS10575	COG1607	acyl-coa hydrolase
E3H47_RS10590	COG1309	transcriptional regulator
E3H47_RS10595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3H47_RS10605	COG1741	Belongs to the pirin family
E3H47_RS10615	COG2132	Multicopper oxidase
E3H47_RS10630	COG0625	glutathione transferase activity
E3H47_RS10650	COG2031	fatty acid transporter
E3H47_RS10655	COG0183	Belongs to the thiolase family
E3H47_RS10665	COG0589	response to stress
E3H47_RS10710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E3H47_RS10715	COG2814	Major facilitator Superfamily
E3H47_RS10720	COG1566	PFAM secretion protein HlyD family protein
E3H47_RS10725	COG2050	protein possibly involved in aromatic compounds catabolism
E3H47_RS10735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3H47_RS10740	COG1090	epimerase
E3H47_RS10750	COG0420	3'-5' exonuclease activity
E3H47_RS10775	COG0735	belongs to the Fur family
E3H47_RS10780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3H47_RS10800	COG0121	glutamine amidotransferase
E3H47_RS10810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3H47_RS10815	COG0756	dUTP diphosphatase activity
E3H47_RS10825	COG2885	chlorophyll binding
E3H47_RS10830	COG0204	Acyl-transferase
E3H47_RS10845	COG2894	cell division
E3H47_RS10850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3H47_RS10860	COG1674	ftsk spoiiie
E3H47_RS10865	COG0492	ferredoxin-NADP+ reductase activity
E3H47_RS10870	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3H47_RS10880	COG0456	acetyltransferase
E3H47_RS10920	COG1981	membrane
E3H47_RS10930	COG0352	thiamine-phosphate diphosphorylase activity
E3H47_RS10930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E3H47_RS10930	COG0351	phosphomethylpyrimidine kinase
E3H47_RS10935	COG1652	LysM domain
E3H47_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS10960	COG1399	metal-binding, possibly nucleic acid-binding protein
E3H47_RS10965	COG3101	peptidyl-lysine hydroxylation
E3H47_RS10970	COG0009	L-threonylcarbamoyladenylate synthase
E3H47_RS10980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E3H47_RS10985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3H47_RS11000	COG4106	trans-aconitate 2-methyltransferase activity
E3H47_RS11015	COG2226	methyltransferase
E3H47_RS11015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_RS11015	COG0596	Alpha beta hydrolase
E3H47_RS11020	COG2193	ferroxidase activity
E3H47_RS11030	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E3H47_RS11035	COG2223	nitrite transmembrane transporter activity
E3H47_RS11040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3H47_RS11050	COG1196	nuclear chromosome segregation
E3H47_RS11060	COG0730	response to heat
E3H47_RS11075	COG3545	Serine hydrolase
E3H47_RS11080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3H47_RS11090	COG2226	methyltransferase
E3H47_RS11095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3H47_RS11125	COG0564	pseudouridine synthase activity
E3H47_RS11155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3H47_RS11170	COG1902	pentaerythritol trinitrate reductase activity
E3H47_RS11175	COG2094	Belongs to the DNA glycosylase MPG family
E3H47_RS11185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3H47_RS11190	COG1970	mechanosensitive ion channel activity
E3H47_RS11195	COG1217	gtp-binding protein TYPA
E3H47_RS11200	COG2233	PERMEase
E3H47_RS11210	COG0833	amino acid
E3H47_RS11225	COG0183	Belongs to the thiolase family
E3H47_RS11265	COG1376	ErfK ybiS ycfS ynhG family protein
E3H47_RS11270	COG2832	Protein of unknown function (DUF454)
E3H47_RS11280	COG5510	response to toxic substance
E3H47_RS11285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3H47_RS11295	COG2198	Histidine kinase
E3H47_RS11295	COG0643	Histidine kinase
E3H47_RS11300	COG0840	transmembrane signaling receptor activity
E3H47_RS11335	COG0442	prolyl-tRNA aminoacylation
E3H47_RS11370	COG0489	protein tyrosine kinase activity
E3H47_RS11375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3H47_RS11375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3H47_RS11410	COG2081	HI0933 family
E3H47_RS11420	COG0668	transmembrane transport
E3H47_RS11440	COG0583	DNA-binding transcription factor activity
E3H47_RS11455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3H47_RS11460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3H47_RS11465	COG0713	ATP synthesis coupled electron transport
E3H47_RS11475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3H47_RS11490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3H47_RS11510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3H47_RS11525	COG2205	protein histidine kinase activity
E3H47_RS11530	COG0745	RESPONSE REGULATOR receiver
E3H47_RS11550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3H47_RS11555	COG0583	DNA-binding transcription factor activity
E3H47_RS11560	COG4773	Receptor
E3H47_RS11575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3H47_RS11585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3H47_RS11610	COG1968	undecaprenyl-diphosphatase activity
E3H47_RS11615	COG1214	PFAM Peptidase M22, glycoprotease
E3H47_RS11620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3H47_RS11625	COG0494	nUDIX hydrolase
E3H47_RS11665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3H47_RS11675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3H47_RS11680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3H47_RS11685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3H47_RS11755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3H47_RS11770	COG0450	alkyl hydroperoxide reductase
E3H47_RS11785	COG0285	dihydrofolate synthase activity
E3H47_RS11790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3H47_RS11835	COG4206	TonB-dependent receptor
E3H47_RS11840	COG2096	Adenosyltransferase
E3H47_RS11860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E3H47_RS11865	COG0745	RESPONSE REGULATOR receiver
E3H47_RS11870	COG2205	protein histidine kinase activity
E3H47_RS11880	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS11885	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS11890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3H47_RS11895	COG1162	GTPase activity
E3H47_RS11905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3H47_RS11910	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3H47_RS11915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3H47_RS11920	COG2003	Belongs to the UPF0758 family
E3H47_RS11925	COG3781	membrane
E3H47_RS11940	COG2350	Protein conserved in bacteria
E3H47_RS11960	COG1666	GTP binding
E3H47_RS11970	COG1607	acyl-coa hydrolase
E3H47_RS12035	COG1183	phosphatidylcholine synthase activity
E3H47_RS12040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3H47_RS12070	COG0741	lytic transglycosylase activity
E3H47_RS12070	COG0739	heme binding
E3H47_RS12070	COG1196	nuclear chromosome segregation
E3H47_RS12075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3H47_RS12080	COG1702	phosphate starvation-inducible protein PhoH
E3H47_RS12085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3H47_RS12120	COG1295	ribonuclease BN
E3H47_RS12125	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3H47_RS12160	COG0557	exoribonuclease II activity
E3H47_RS12165	COG0339	signal peptide processing
E3H47_RS12170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E3H47_RS12200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3H47_RS12205	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS12210	COG2072	flavoprotein involved in K transport
E3H47_RS12215	COG0203	ribosomal protein L17
E3H47_RS12220	COG0202	RNA polymerase activity
E3H47_RS12225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3H47_RS12260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3H47_RS12275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3H47_RS12290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3H47_RS12295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3H47_RS12300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3H47_RS12315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3H47_RS12325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3H47_RS12335	COG0089	rRNA binding
E3H47_RS12340	COG0088	Forms part of the polypeptide exit tunnel
E3H47_RS12345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3H47_RS12360	COG0626	cystathionine gamma-synthase activity
E3H47_RS12365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3H47_RS12365	COG1017	nitric oxide dioxygenase activity
E3H47_RS12370	COG1959	2 iron, 2 sulfur cluster binding
E3H47_RS12380	COG1301	dicarboxylic acid transport
E3H47_RS12385	COG1946	Acyl-CoA thioesterase
E3H47_RS12390	COG2937	Belongs to the GPAT DAPAT family
E3H47_RS12400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3H47_RS12405	COG1040	competence protein
E3H47_RS12420	COG0598	Magnesium transport protein CorA
E3H47_RS12430	COG2854	intermembrane phospholipid transfer
E3H47_RS12435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3H47_RS12440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3H47_RS12445	COG1127	ABC transporter
E3H47_RS12460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3H47_RS12470	COG0408	coproporphyrinogen oxidase activity
E3H47_RS12490	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS12500	COG1983	PspC domain protein
E3H47_RS12515	COG0752	glycyl-tRNA synthetase alpha subunit
E3H47_RS12520	COG0751	glycine-tRNA ligase activity
E3H47_RS12540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3H47_RS12580	COG0628	permease
E3H47_RS12585	COG2032	superoxide dismutase activity
E3H47_RS12600	COG0277	FAD linked oxidase domain protein
E3H47_RS12605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3H47_RS12615	COG5006	permease, DMT superfamily
E3H47_RS12630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3H47_RS12635	COG5380	lipid catabolic process
E3H47_RS12640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E3H47_RS12650	COG0335	large ribosomal subunit rRNA binding
E3H47_RS12660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3H47_RS12665	COG0228	four-way junction DNA binding
E3H47_RS12710	COG0194	GDP metabolic process
E3H47_RS12715	COG1758	RNA polymerase activity
E3H47_RS12720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3H47_RS12770	COG0463	Glycosyl transferase, family 2
E3H47_RS12790	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3H47_RS12795	COG1704	LemA family
E3H47_RS12805	COG0493	'glutamate synthase
E3H47_RS12810	COG0070	glutamate synthase
E3H47_RS12810	COG0067	glutamate synthase
E3H47_RS12810	COG0069	glutamate synthase activity
E3H47_RS12860	COG2226	methyltransferase
E3H47_RS12870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3H47_RS12875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3H47_RS12890	COG0275	rRNA processing
E3H47_RS12895	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3H47_RS12905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3H47_RS12930	COG0488	(ABC) transporter
E3H47_RS12940	COG4221	oxidoreductase activity
E3H47_RS12970	COG0427	acetyl-CoA hydrolase
E3H47_RS13000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3H47_RS13015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3H47_RS13020	COG0697	spore germination
E3H47_RS13035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3H47_RS13040	COG0107	imidazoleglycerol-phosphate synthase activity
E3H47_RS13095	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E3H47_RS13105	COG1058	Belongs to the CinA family
E3H47_RS13105	COG1546	Belongs to the CinA family
E3H47_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
E3H47_RS13135	COG1196	nuclear chromosome segregation
E3H47_RS13170	COG0629	single-stranded DNA binding
E3H47_RS13175	COG2814	Major facilitator Superfamily
E3H47_RS13190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E3H47_RS13190	COG0351	phosphomethylpyrimidine kinase
E3H47_RS13190	COG0352	thiamine-phosphate diphosphorylase activity
E3H47_RS13210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3H47_RS13230	COG3162	membrane
E3H47_RS13235	COG2205	protein histidine kinase activity
E3H47_RS13235	COG2198	Histidine kinase
E3H47_RS13235	COG0784	Response regulator, receiver
E3H47_RS13265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3H47_RS13270	COG3152	Membrane
E3H47_RS13275	COG0668	transmembrane transport
E3H47_RS13285	COG1519	Transferase
E3H47_RS13290	COG1902	pentaerythritol trinitrate reductase activity
E3H47_RS13305	COG0586	Pfam SNARE associated Golgi protein
E3H47_RS13320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3H47_RS13345	COG0426	domain, Protein
E3H47_RS13345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3H47_RS13350	COG2119	membrane
E3H47_RS13380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3H47_RS13390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3H47_RS13400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3H47_RS13410	COG2814	Major facilitator Superfamily
E3H47_RS13420	COG0189	ligase activity
E3H47_RS13430	COG0708	Exodeoxyribonuclease III
E3H47_RS13455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3H47_RS13455	COG0666	response to abiotic stimulus
E3H47_RS13475	COG3150	esterase
E3H47_RS13490	COG2918	glutathione biosynthetic process
E3H47_RS13510	COG0436	Aminotransferase
E3H47_RS13515	COG0534	Mate efflux family protein
E3H47_RS13540	COG0688	phosphatidylethanolamine metabolic process
E3H47_RS13560	COG0753	catalase activity
E3H47_RS13580	COG3830	Belongs to the UPF0237 family
E3H47_RS13580	COG0560	Phosphoserine phosphatase
E3H47_RS13595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3H47_RS13600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3H47_RS13610	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3H47_RS13620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3H47_RS13625	COG0697	spore germination
E3H47_RS13630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3H47_RS13635	COG0385	Bile acid
E3H47_RS13640	COG1335	isochorismatase
E3H47_RS13645	COG2814	Major facilitator Superfamily
E3H47_RS13650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3H47_RS13670	COG2155	Conserved Protein
E3H47_RS13675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3H47_RS13680	COG2133	pyrroloquinoline quinone binding
E3H47_RS13685	COG0789	Transcriptional regulator
E3H47_RS13695	COG2983	Belongs to the UPF0260 family
E3H47_RS13700	COG5487	UPF0391 membrane protein
E3H47_RS13715	COG1194	a g-specific adenine glycosylase
E3H47_RS13730	COG2818	Glycosylase
E3H47_RS13735	COG1064	alcohol dehydrogenase
E3H47_RS13750	COG0583	DNA-binding transcription factor activity
E3H47_RS13755	COG0656	L-ascorbic acid biosynthetic process
E3H47_RS13760	COG2814	Major facilitator Superfamily
E3H47_RS13800	COG1309	transcriptional regulator
E3H47_RS13810	COG2233	PERMEase
E3H47_RS13825	COG0546	phosphoglycolate phosphatase activity
E3H47_RS13835	COG0129	dihydroxy-acid dehydratase activity
E3H47_RS13850	COG0428	transporter
E3H47_RS13860	COG0733	neurotransmitter:sodium symporter activity
E3H47_RS13910	COG1846	Transcriptional regulator
E3H47_RS13945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3H47_RS13955	COG0657	acetylesterase activity
E3H47_RS13970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3H47_RS13985	COG2951	lytic endotransglycosylase activity
E3H47_RS13990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3H47_RS14005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3H47_RS14010	COG0318	PFAM AMP-dependent synthetase and ligase
E3H47_RS14015	COG1960	acyl-CoA dehydrogenase activity
E3H47_RS14025	COG2814	Major facilitator Superfamily
E3H47_RS14035	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3H47_RS14050	COG0402	S-adenosylhomocysteine deaminase activity
E3H47_RS14070	COG1230	cation diffusion facilitator family transporter
E3H47_RS14085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3H47_RS14090	COG0706	membrane insertase activity
E3H47_RS14095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3H47_RS14100	COG0594	ribonuclease P activity
E3H47_RS14150	COG1373	ATPase (AAA superfamily
E3H47_RS14240	COG2132	Multicopper oxidase
E3H47_RS14280	COG2132	Multicopper oxidase
E3H47_RS14295	COG2205	protein histidine kinase activity
E3H47_RS14300	COG3174	membrane
E3H47_RS14305	COG2217	Heavy metal translocating P-type atpase
E3H47_RS14360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3H47_RS14370	COG1063	alcohol dehydrogenase
E3H47_RS14450	COG3077	Addiction module antitoxin, RelB DinJ family
E3H47_RS14460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3H47_RS14470	COG0640	Transcriptional regulator
E3H47_RS14480	COG0798	PFAM Bile acid sodium symporter
E3H47_RS14485	COG0431	NADPH-dependent FMN reductase
E3H47_RS14490	COG0492	ferredoxin-NADP+ reductase activity
E3H47_RS14540	COG0642	Histidine kinase
E3H47_RS14545	COG0745	RESPONSE REGULATOR receiver
E3H47_RS14550	COG2194	sulfuric ester hydrolase activity
E3H47_RS14580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3H47_RS14595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3H47_RS14635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3H47_RS14650	COG0642	Histidine kinase
E3H47_RS14660	COG2801	Transposase and inactivated derivatives
E3H47_RS14675	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E3H47_RS14755	COG3451	type IV secretory pathway VirB4
E3H47_RS14775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3H47_RS14830	COG1192	Involved in chromosome partitioning
E3H47_RS14865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3H47_RS14965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3H47_RS14975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3H47_RS14985	COG2026	Addiction module toxin, RelE StbE family
E3H47_RS15005	COG2072	flavoprotein involved in K transport
E3H47_RS15015	COG2144	transferase activity, transferring acyl groups
E3H47_RS15040	COG3604	Transcriptional regulator
E3H47_RS15045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3H47_RS15075	COG1192	Involved in chromosome partitioning
E3H47_RS15080	COG1475	DNA binding
E3H47_RS15130	COG0582	viral genome integration into host DNA
E3H47_RS15145	COG3485	protocatechuate 3,4-dioxygenase
E3H47_RS15150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3H47_RS15155	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3H47_RS15160	COG0583	DNA-binding transcription factor activity
E3H47_RS15165	COG4948	Mandelate Racemase Muconate Lactonizing
E3H47_RS15170	COG4829	muconolactone delta-isomerase
E3H47_RS15175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3H47_RS15180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3H47_RS15185	COG0183	Belongs to the thiolase family
E3H47_RS15190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3H47_RS15200	COG4680	protein conserved in bacteria
E3H47_RS15255	COG1309	transcriptional regulator
E3H47_RS15290	COG0633	Ferredoxin
E3H47_RS15295	COG2207	Transcriptional regulator
E3H47_RS15350	COG2871	sodium ion transport