locus-tag	class	description
DPR03_RS00010	COG0592	DNA-directed DNA polymerase activity
DPR03_RS00020	COG0187	DNA topoisomerase II activity
DPR03_RS00030	COG1063	alcohol dehydrogenase
DPR03_RS00035	COG0488	(ABC) transporter
DPR03_RS00090	COG0657	acetylesterase activity
DPR03_RS00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DPR03_RS00135	COG2814	Major facilitator Superfamily
DPR03_RS00150	COG0693	protein deglycase activity
DPR03_RS00160	COG1012	belongs to the aldehyde dehydrogenase family
DPR03_RS00165	COG0733	neurotransmitter:sodium symporter activity
DPR03_RS00175	COG0428	transporter
DPR03_RS00200	COG0129	dihydroxy-acid dehydratase activity
DPR03_RS00220	COG0583	DNA-binding transcription factor activity
DPR03_RS00225	COG2233	PERMEase
DPR03_RS00240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPR03_RS00260	COG0783	Belongs to the Dps family
DPR03_RS00275	COG1064	alcohol dehydrogenase
DPR03_RS00280	COG2818	Glycosylase
DPR03_RS00295	COG1194	a g-specific adenine glycosylase
DPR03_RS00310	COG0545	Peptidyl-prolyl cis-trans isomerase
DPR03_RS00345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DPR03_RS00370	COG0438	transferase activity, transferring glycosyl groups
DPR03_RS00375	COG0438	transferase activity, transferring glycosyl groups
DPR03_RS00380	COG0438	transferase activity, transferring glycosyl groups
DPR03_RS00385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DPR03_RS00395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DPR03_RS00415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DPR03_RS00430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DPR03_RS00435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DPR03_RS00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DPR03_RS00450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DPR03_RS00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DPR03_RS00460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DPR03_RS00505	COG1192	Involved in chromosome partitioning
DPR03_RS00520	COG0586	Pfam SNARE associated Golgi protein
DPR03_RS00525	COG2259	Doxx family
DPR03_RS00535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DPR03_RS00535	COG0519	Catalyzes the synthesis of GMP from XMP
DPR03_RS00550	COG3706	GGDEF domain
DPR03_RS00595	COG0534	Mate efflux family protein
DPR03_RS00600	COG0436	Aminotransferase
DPR03_RS00620	COG2837	iron assimilation
DPR03_RS00630	COG3123	guanosine phosphorylase activity
DPR03_RS00635	COG1683	Conserved Protein
DPR03_RS00640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DPR03_RS00645	COG1121	(ABC) transporter
DPR03_RS00695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DPR03_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
DPR03_RS00720	COG0386	Belongs to the glutathione peroxidase family
DPR03_RS00725	COG0697	spore germination
DPR03_RS00740	COG0758	DNA mediated transformation
DPR03_RS00795	COG2814	Major facilitator Superfamily
DPR03_RS00815	COG0477	Major facilitator Superfamily
DPR03_RS00820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DPR03_RS00850	COG1253	flavin adenine dinucleotide binding
DPR03_RS00860	COG2860	membrane
DPR03_RS00865	COG0477	Major facilitator Superfamily
DPR03_RS00875	COG0318	PFAM AMP-dependent synthetase and ligase
DPR03_RS00890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DPR03_RS00915	COG0606	chelatase, subunit chli
DPR03_RS00925	COG0347	Belongs to the P(II) protein family
DPR03_RS00930	COG0004	ammonium transporteR
DPR03_RS00940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DPR03_RS00940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DPR03_RS00955	COG0586	Pfam SNARE associated Golgi protein
DPR03_RS00975	COG0795	lipopolysaccharide-transporting ATPase activity
DPR03_RS00980	COG0795	lipopolysaccharide-transporting ATPase activity
DPR03_RS00985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DPR03_RS00990	COG0793	Belongs to the peptidase S41A family
DPR03_RS01000	COG5002	protein histidine kinase activity
DPR03_RS01005	COG2197	response regulator
DPR03_RS01015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DPR03_RS01025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DPR03_RS01030	COG4974	Belongs to the 'phage' integrase family
DPR03_RS01055	COG0772	Belongs to the SEDS family
DPR03_RS01065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DPR03_RS01070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DPR03_RS01075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DPR03_RS01080	COG0494	nUDIX hydrolase
DPR03_RS01085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DPR03_RS01095	COG1538	Outer membrane efflux protein
DPR03_RS01100	COG1216	Glycosyl transferase, family 2
DPR03_RS01110	COG1132	(ABC) transporter
DPR03_RS01120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DPR03_RS01130	COG0497	DNA recombination
DPR03_RS01135	COG3123	guanosine phosphorylase activity
DPR03_RS01140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DPR03_RS01150	COG0237	dephospho-CoA kinase activity
DPR03_RS01175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DPR03_RS01205	COG0779	Required for maturation of 30S ribosomal subunits
DPR03_RS01210	COG0195	Participates in both transcription termination and antitermination
DPR03_RS01215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DPR03_RS01220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DPR03_RS01225	COG1320	monovalent cation:proton antiporter activity
DPR03_RS01230	COG2212	antiporter activity
DPR03_RS01235	COG1863	multisubunit Na H antiporter MnhE subunit
DPR03_RS01240	COG0651	ATP synthesis coupled electron transport
DPR03_RS01245	COG1006	Multisubunit Na H antiporter MnhC subunit
DPR03_RS01250	COG2111	Na H antiporter
DPR03_RS01250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DPR03_RS01265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DPR03_RS01270	COG4221	oxidoreductase activity
DPR03_RS01275	COG2873	o-acetylhomoserine
DPR03_RS01280	COG0488	(ABC) transporter
DPR03_RS01320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DPR03_RS01340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DPR03_RS01345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DPR03_RS01350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DPR03_RS01355	COG2226	methyltransferase
DPR03_RS01405	COG0069	glutamate synthase activity
DPR03_RS01405	COG0067	glutamate synthase
DPR03_RS01405	COG0070	glutamate synthase
DPR03_RS01410	COG0493	'glutamate synthase
DPR03_RS01415	COG1704	LemA family
DPR03_RS01435	COG3307	-O-antigen
DPR03_RS01455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DPR03_RS01460	COG1758	RNA polymerase activity
DPR03_RS01465	COG0194	GDP metabolic process
DPR03_RS01510	COG0228	four-way junction DNA binding
DPR03_RS01515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DPR03_RS01525	COG0335	large ribosomal subunit rRNA binding
DPR03_RS01550	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DPR03_RS01555	COG5380	lipid catabolic process
DPR03_RS01560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DPR03_RS01585	COG5006	permease, DMT superfamily
DPR03_RS01590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DPR03_RS01595	COG0277	FAD linked oxidase domain protein
DPR03_RS01610	COG2814	Major facilitator Superfamily
DPR03_RS01620	COG0628	permease
DPR03_RS01655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DPR03_RS01660	COG0254	rRNA binding
DPR03_RS01665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DPR03_RS01680	COG0534	Mate efflux family protein
DPR03_RS01690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DPR03_RS01700	COG1278	Cold shock
DPR03_RS01705	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS01720	COG0408	coproporphyrinogen oxidase activity
DPR03_RS01725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DPR03_RS01735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DPR03_RS01750	COG1127	ABC transporter
DPR03_RS01755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DPR03_RS01760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DPR03_RS01765	COG2854	intermembrane phospholipid transfer
DPR03_RS01775	COG0598	Magnesium transport protein CorA
DPR03_RS01785	COG0494	nUDIX hydrolase
DPR03_RS01790	COG1040	competence protein
DPR03_RS01795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DPR03_RS01805	COG2937	Belongs to the GPAT DAPAT family
DPR03_RS01810	COG1946	Acyl-CoA thioesterase
DPR03_RS01815	COG1301	dicarboxylic acid transport
DPR03_RS01835	COG1959	2 iron, 2 sulfur cluster binding
DPR03_RS01845	COG0433	COG0433 Predicted ATPase
DPR03_RS01850	COG0626	cystathionine gamma-synthase activity
DPR03_RS01870	COG0088	Forms part of the polypeptide exit tunnel
DPR03_RS01875	COG0089	rRNA binding
DPR03_RS01885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DPR03_RS01935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DPR03_RS01940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DPR03_RS01950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DPR03_RS01975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DPR03_RS01985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DPR03_RS01990	COG0202	RNA polymerase activity
DPR03_RS01995	COG0203	ribosomal protein L17
DPR03_RS02000	COG2072	flavoprotein involved in K transport
DPR03_RS02005	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS02010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DPR03_RS02045	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DPR03_RS02050	COG0339	signal peptide processing
DPR03_RS02060	COG0557	exoribonuclease II activity
DPR03_RS02095	COG0179	Fumarylacetoacetate (FAA) hydrolase
DPR03_RS02110	COG1295	ribonuclease BN
DPR03_RS02175	COG1702	phosphate starvation-inducible protein PhoH
DPR03_RS02180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DPR03_RS02185	COG0739	heme binding
DPR03_RS02185	COG0741	lytic transglycosylase activity
DPR03_RS02185	COG1196	nuclear chromosome segregation
DPR03_RS02225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DPR03_RS02230	COG1183	phosphatidylcholine synthase activity
DPR03_RS02270	COG1283	sodium-dependent phosphate transmembrane transporter activity
DPR03_RS02305	COG1607	acyl-coa hydrolase
DPR03_RS02340	COG2350	Protein conserved in bacteria
DPR03_RS02360	COG3781	membrane
DPR03_RS02365	COG2003	Belongs to the UPF0758 family
DPR03_RS02370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DPR03_RS02380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DPR03_RS02390	COG2814	Major facilitator Superfamily
DPR03_RS02415	COG0004	ammonium transporteR
DPR03_RS02430	COG3622	Belongs to the hyi family
DPR03_RS02435	COG2084	Dehydrogenase
DPR03_RS02440	COG1024	Enoyl-CoA hydratase
DPR03_RS02445	COG2205	protein histidine kinase activity
DPR03_RS02445	COG5002	protein histidine kinase activity
DPR03_RS02445	COG0784	Response regulator, receiver
DPR03_RS02450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DPR03_RS02465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DPR03_RS02475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DPR03_RS02485	COG1862	Preprotein translocase
DPR03_RS02500	COG1704	LemA family
DPR03_RS02510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DPR03_RS02540	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS02545	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS02555	COG2205	protein histidine kinase activity
DPR03_RS02560	COG0745	RESPONSE REGULATOR receiver
DPR03_RS02565	COG1113	amino acid transport
DPR03_RS02595	COG2096	Adenosyltransferase
DPR03_RS02600	COG4206	TonB-dependent receptor
DPR03_RS02640	COG0159	tryptophan synthase activity
DPR03_RS02650	COG0285	dihydrofolate synthase activity
DPR03_RS02665	COG0450	alkyl hydroperoxide reductase
DPR03_RS02680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DPR03_RS02685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DPR03_RS02760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DPR03_RS02765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DPR03_RS02790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DPR03_RS02795	COG1408	metallophosphoesterase
DPR03_RS02805	COG0477	Major facilitator Superfamily
DPR03_RS02810	COG1272	protein, Hemolysin III
DPR03_RS02830	COG1250	3-hydroxyacyl-CoA dehydrogenase
DPR03_RS02830	COG1024	Enoyl-CoA hydratase
DPR03_RS02835	COG0183	Belongs to the thiolase family
DPR03_RS02840	COG2207	Transcriptional regulator
DPR03_RS02845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DPR03_RS02850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DPR03_RS02865	COG0183	Belongs to the thiolase family
DPR03_RS02885	COG0833	amino acid
DPR03_RS02895	COG2233	PERMEase
DPR03_RS02900	COG1217	gtp-binding protein TYPA
DPR03_RS02905	COG1970	mechanosensitive ion channel activity
DPR03_RS02925	COG1902	pentaerythritol trinitrate reductase activity
DPR03_RS02945	COG0354	folic acid binding
DPR03_RS02950	COG2132	Multicopper oxidase
DPR03_RS02955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DPR03_RS03005	COG0564	pseudouridine synthase activity
DPR03_RS03025	COG2824	Alkylphosphonate utilization operon protein PhnA
DPR03_RS03040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DPR03_RS03040	COG0351	phosphomethylpyrimidine kinase
DPR03_RS03040	COG0352	thiamine-phosphate diphosphorylase activity
DPR03_RS03080	COG4772	TonB-dependent receptor
DPR03_RS03085	COG0431	NADPH-dependent FMN reductase
DPR03_RS03090	COG0798	PFAM Bile acid sodium symporter
DPR03_RS03095	COG0640	Transcriptional regulator
DPR03_RS03105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DPR03_RS03110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DPR03_RS03110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DPR03_RS03115	COG0745	RESPONSE REGULATOR receiver
DPR03_RS03120	COG2205	protein histidine kinase activity
DPR03_RS03130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DPR03_RS03150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DPR03_RS03165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DPR03_RS03175	COG0713	ATP synthesis coupled electron transport
DPR03_RS03180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DPR03_RS03185	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DPR03_RS03210	COG0583	DNA-binding transcription factor activity
DPR03_RS03235	COG4302	ethanolamine ammonia-lyase activity
DPR03_RS03245	COG0668	transmembrane transport
DPR03_RS03250	COG2081	HI0933 family
DPR03_RS03260	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DPR03_RS03275	COG0004	ammonium transporteR
DPR03_RS03290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DPR03_RS03290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DPR03_RS03305	COG3328	transposase activity
DPR03_RS03310	COG0489	protein tyrosine kinase activity
DPR03_RS03355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPR03_RS03380	COG0840	transmembrane signaling receptor activity
DPR03_RS03385	COG0643	Histidine kinase
DPR03_RS03385	COG0784	Response regulator, receiver
DPR03_RS03385	COG2198	Histidine kinase
DPR03_RS03470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DPR03_RS03480	COG1289	transmembrane transporter activity
DPR03_RS03485	COG2814	Major facilitator Superfamily
DPR03_RS03495	COG0786	glutamate:sodium symporter activity
DPR03_RS03500	COG1115	amino acid carrier protein
DPR03_RS03510	COG1752	Esterase of the alpha-beta hydrolase superfamily
DPR03_RS03515	COG1607	acyl-coa hydrolase
DPR03_RS03525	COG2814	Major facilitator Superfamily
DPR03_RS03550	COG0523	cobalamin synthesis protein
DPR03_RS03560	COG1285	pathogenesis
DPR03_RS03570	COG4251	negative regulation of phosphorylation
DPR03_RS03570	COG5001	Diguanylate cyclase
DPR03_RS03570	COG2203	Gaf domain
DPR03_RS03570	COG3706	GGDEF domain
DPR03_RS03605	COG0393	Putative heavy-metal-binding
DPR03_RS03610	COG0393	Putative heavy-metal-binding
DPR03_RS03615	COG1538	Outer membrane efflux protein
DPR03_RS03625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPR03_RS03640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DPR03_RS03650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DPR03_RS03660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DPR03_RS03665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DPR03_RS03665	COG1648	precorrin-2 dehydrogenase activity
DPR03_RS03670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DPR03_RS03680	COG0531	amino acid
DPR03_RS03695	COG0321	lipoyl(octanoyl) transferase activity
DPR03_RS03700	COG2921	Belongs to the UPF0250 family
DPR03_RS03705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DPR03_RS03730	COG0586	Pfam SNARE associated Golgi protein
DPR03_RS03755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DPR03_RS03785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DPR03_RS03815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DPR03_RS03830	COG0358	DNA primase activity
DPR03_RS03840	COG0564	pseudouridine synthase activity
DPR03_RS03865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DPR03_RS03885	COG0110	maltose O-acetyltransferase activity
DPR03_RS03890	COG0251	oxidation-reduction process
DPR03_RS03895	COG1309	transcriptional regulator
DPR03_RS03905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DPR03_RS03910	COG0505	Belongs to the CarA family
DPR03_RS03935	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DPR03_RS03940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DPR03_RS03950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DPR03_RS03985	COG1253	flavin adenine dinucleotide binding
DPR03_RS04005	COG2239	Acts as a magnesium transporter
DPR03_RS04015	COG0501	Belongs to the peptidase M48B family
DPR03_RS04020	COG1196	nuclear chromosome segregation
DPR03_RS04020	COG0741	lytic transglycosylase activity
DPR03_RS04020	COG0739	heme binding
DPR03_RS04025	COG0037	tRNA processing
DPR03_RS04035	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DPR03_RS04045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DPR03_RS04060	COG0583	DNA-binding transcription factor activity
DPR03_RS04065	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS04070	COG2814	Major facilitator Superfamily
DPR03_RS04075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DPR03_RS04085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DPR03_RS04110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DPR03_RS04115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DPR03_RS04120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DPR03_RS04130	COG3328	transposase activity
DPR03_RS04135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DPR03_RS04170	COG1115	amino acid carrier protein
DPR03_RS04175	COG1113	amino acid transport
DPR03_RS04185	COG0019	diaminopimelate decarboxylase activity
DPR03_RS04195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DPR03_RS04205	COG1522	sequence-specific DNA binding
DPR03_RS04210	COG1280	lysine exporter protein (LysE YggA)
DPR03_RS04250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPR03_RS04275	COG1671	Belongs to the UPF0178 family
DPR03_RS04290	COG4591	ABC-type transport system involved in lipoprotein release permease component
DPR03_RS04295	COG1136	(ABC) transporter
DPR03_RS04300	COG2333	competence protein COMEC
DPR03_RS04300	COG0658	competence protein
DPR03_RS04320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DPR03_RS04325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DPR03_RS04330	COG0628	permease
DPR03_RS04335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DPR03_RS04365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DPR03_RS04380	COG2885	chlorophyll binding
DPR03_RS04385	COG0823	Involved in the tonB-independent uptake of proteins
DPR03_RS04405	COG0824	Thioesterase
DPR03_RS04420	COG1473	amidohydrolase
DPR03_RS04435	COG2255	four-way junction helicase activity
DPR03_RS04450	COG0047	phosphoribosylformylglycinamidine synthase activity
DPR03_RS04450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DPR03_RS04480	COG0778	Nitroreductase
DPR03_RS04485	COG1024	Enoyl-CoA hydratase
DPR03_RS04490	COG1056	cytidyltransferase-related domain
DPR03_RS04490	COG1051	belongs to the nudix hydrolase family
DPR03_RS04495	COG2353	YceI-like domain
DPR03_RS04500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DPR03_RS04510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DPR03_RS04515	COG0602	queuosine metabolic process
DPR03_RS04530	COG0583	DNA-binding transcription factor activity
DPR03_RS04535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DPR03_RS04540	COG4208	sulfate ABC transporter
DPR03_RS04555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DPR03_RS04560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DPR03_RS04570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DPR03_RS04590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DPR03_RS04615	COG0571	ribonuclease III activity
DPR03_RS04620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DPR03_RS04630	COG1381	Involved in DNA repair and RecF pathway recombination
DPR03_RS04635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DPR03_RS04665	COG0436	Aminotransferase
DPR03_RS04670	COG0024	Methionine aminopeptidase
DPR03_RS04675	COG0052	Belongs to the universal ribosomal protein uS2 family
DPR03_RS04700	COG2951	lytic endotransglycosylase activity
DPR03_RS04715	COG0842	Transport permease protein
DPR03_RS04720	COG1131	(ABC) transporter
DPR03_RS04730	COG0582	viral genome integration into host DNA
DPR03_RS04855	COG2814	Major facilitator Superfamily
DPR03_RS04865	COG1968	undecaprenyl-diphosphatase activity
DPR03_RS04870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DPR03_RS04875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DPR03_RS04885	COG2205	protein histidine kinase activity
DPR03_RS04930	COG1278	Cold shock
DPR03_RS04985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DPR03_RS05005	COG3634	alkyl hydroperoxide reductase activity
DPR03_RS05010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DPR03_RS05015	COG0826	peptidase U32
DPR03_RS05020	COG0789	Transcriptional regulator
DPR03_RS05035	COG1720	tRNA m6t6A37 methyltransferase activity
DPR03_RS05045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DPR03_RS05060	COG0642	Histidine kinase
DPR03_RS05070	COG0494	nUDIX hydrolase
DPR03_RS05080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DPR03_RS05085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DPR03_RS05090	COG3139	Protein of unknown function (DUF1315)
DPR03_RS05100	COG1301	dicarboxylic acid transport
DPR03_RS05105	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS05110	COG0693	protein deglycase activity
DPR03_RS05120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DPR03_RS05125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DPR03_RS05145	COG2252	PERMEase
DPR03_RS05150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DPR03_RS05165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DPR03_RS05175	COG0527	aspartate kinase activity
DPR03_RS05185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DPR03_RS05200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DPR03_RS05215	COG1047	Peptidyl-prolyl cis-trans
DPR03_RS05220	COG1252	NADH dehydrogenase
DPR03_RS05225	COG1686	Belongs to the peptidase S11 family
DPR03_RS05240	COG2351	hydroxyisourate hydrolase activity
DPR03_RS05260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DPR03_RS05260	COG2755	lipolytic protein G-D-S-L family
DPR03_RS05265	COG0436	Aminotransferase
DPR03_RS05270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DPR03_RS05275	COG0386	Belongs to the glutathione peroxidase family
DPR03_RS05290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DPR03_RS05325	COG0012	GTP binding
DPR03_RS05330	COG2011	ABC-type metal ion transport system permease component
DPR03_RS05335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DPR03_RS05340	COG1464	Belongs to the NlpA lipoprotein family
DPR03_RS05380	COG0204	Acyl-transferase
DPR03_RS05390	COG0582	viral genome integration into host DNA
DPR03_RS05395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DPR03_RS05435	COG3586	endonuclease activity
DPR03_RS05495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DPR03_RS05495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DPR03_RS05530	COG3634	alkyl hydroperoxide reductase activity
DPR03_RS05560	COG1643	Atp-dependent helicase
DPR03_RS05580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DPR03_RS05610	COG0802	atpase or kinase
DPR03_RS05615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DPR03_RS05625	COG1923	regulation of RNA biosynthetic process
DPR03_RS05630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DPR03_RS05640	COG3178	'Phosphotransferase
DPR03_RS05645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DPR03_RS05655	COG1192	Involved in chromosome partitioning
DPR03_RS05660	COG1475	DNA binding
DPR03_RS05665	COG0811	peptide transport
DPR03_RS05675	COG1132	(ABC) transporter
DPR03_RS05680	COG1663	tetraacyldisaccharide 4'-kinase activity
DPR03_RS05700	COG0084	hydrolase, TatD family'
DPR03_RS05735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DPR03_RS05765	COG0776	regulation of translation
DPR03_RS05785	COG2431	L-lysine efflux transmembrane transporter activity
DPR03_RS05800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DPR03_RS05825	COG1253	flavin adenine dinucleotide binding
DPR03_RS05855	COG0308	aminopeptidase N
DPR03_RS05865	COG0589	response to stress
DPR03_RS05870	COG0589	response to stress
DPR03_RS05880	COG3135	benzoate transporter
DPR03_RS05890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DPR03_RS05905	COG0183	Belongs to the thiolase family
DPR03_RS05935	COG0824	Thioesterase
DPR03_RS05940	COG1454	alcohol dehydrogenase
DPR03_RS05945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DPR03_RS05950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DPR03_RS05965	COG0069	glutamate synthase activity
DPR03_RS05975	COG2308	Evidence 4 Homologs of previously reported genes of
DPR03_RS05985	COG1305	Transglutaminase-like
DPR03_RS06000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DPR03_RS06020	COG0360	Binds together with S18 to 16S ribosomal RNA
DPR03_RS06030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DPR03_RS06035	COG1845	cytochrome c oxidase, subunit III
DPR03_RS06040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DPR03_RS06045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DPR03_RS06070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DPR03_RS06085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DPR03_RS06090	COG2890	protein-(glutamine-N5) methyltransferase activity
DPR03_RS06095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DPR03_RS06100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DPR03_RS06130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DPR03_RS06155	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DPR03_RS06160	COG0477	Major facilitator Superfamily
DPR03_RS06165	COG0729	surface antigen
DPR03_RS06180	COG1570	exodeoxyribonuclease VII activity
DPR03_RS06215	COG0786	glutamate:sodium symporter activity
DPR03_RS06240	COG0024	Methionine aminopeptidase
DPR03_RS06245	COG0583	DNA-binding transcription factor activity
DPR03_RS06250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DPR03_RS06265	COG1902	pentaerythritol trinitrate reductase activity
DPR03_RS06265	COG0446	pyridine nucleotide-disulphide oxidoreductase
DPR03_RS06295	COG0148	phosphopyruvate hydratase activity
DPR03_RS06300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DPR03_RS06310	COG0772	Belongs to the SEDS family
DPR03_RS06330	COG4890	Cyd operon protein YbgT
DPR03_RS06335	COG1294	oxidase, subunit
DPR03_RS06385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DPR03_RS06405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DPR03_RS06415	COG0133	tryptophan synthase activity
DPR03_RS06420	COG0517	IMP dehydrogenase activity
DPR03_RS06450	COG0612	Peptidase, M16
DPR03_RS06455	COG0552	protein localization to endoplasmic reticulum
DPR03_RS06545	COG0456	acetyltransferase
DPR03_RS06550	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS06555	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS06610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DPR03_RS06615	COG0730	response to heat
DPR03_RS06620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DPR03_RS06625	COG2207	Transcriptional regulator
DPR03_RS06630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DPR03_RS06635	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS06640	COG2169	Transcriptional regulator
DPR03_RS06660	COG1525	nuclease
DPR03_RS06720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DPR03_RS06725	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DPR03_RS06735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DPR03_RS06750	COG2814	Major facilitator Superfamily
DPR03_RS06755	COG0509	glycine decarboxylation via glycine cleavage system
DPR03_RS06765	COG2030	dehydratase
DPR03_RS06770	COG1132	(ABC) transporter
DPR03_RS06775	COG0668	transmembrane transport
DPR03_RS06790	COG3122	Protein conserved in bacteria
DPR03_RS06795	COG3619	membrane
DPR03_RS06810	COG0640	Transcriptional regulator
DPR03_RS06815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DPR03_RS06825	COG0789	Transcriptional regulator
DPR03_RS06850	COG0830	nickel cation binding
DPR03_RS06860	COG0829	nickel cation binding
DPR03_RS06865	COG0831	urea catabolic process
DPR03_RS06875	COG0804	urea catabolic process
DPR03_RS06890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DPR03_RS06895	COG0183	Belongs to the thiolase family
DPR03_RS06900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DPR03_RS06905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DPR03_RS06910	COG3135	benzoate transporter
DPR03_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
DPR03_RS06920	COG0543	2 iron, 2 sulfur cluster binding
DPR03_RS06920	COG0633	Ferredoxin
DPR03_RS06925	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DPR03_RS06930	COG4638	Rieske (2fe-2S)
DPR03_RS06940	COG4829	muconolactone delta-isomerase
DPR03_RS06945	COG4948	Mandelate Racemase Muconate Lactonizing
DPR03_RS06950	COG0583	DNA-binding transcription factor activity
DPR03_RS06955	COG2814	Major facilitator Superfamily
DPR03_RS06965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DPR03_RS06970	COG0318	PFAM AMP-dependent synthetase and ligase
DPR03_RS06975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DPR03_RS06975	COG1017	nitric oxide dioxygenase activity
DPR03_RS06990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DPR03_RS06995	COG0583	DNA-binding transcription factor activity
DPR03_RS07010	COG0439	Biotin carboxylase
DPR03_RS07030	COG0864	Transcriptional regulator
DPR03_RS07065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DPR03_RS07070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DPR03_RS07075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DPR03_RS07075	COG1116	anion transmembrane transporter activity
DPR03_RS07085	COG2223	nitrite transmembrane transporter activity
DPR03_RS07090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DPR03_RS07095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DPR03_RS07100	COG0243	molybdopterin cofactor binding
DPR03_RS07110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DPR03_RS07120	COG0314	molybdopterin synthase activity
DPR03_RS07125	COG0521	Mo-molybdopterin cofactor biosynthetic process
DPR03_RS07125	COG0315	cyclic pyranopterin monophosphate synthase activity
DPR03_RS07130	COG0303	'Molybdopterin
DPR03_RS07135	COG0725	ABC transporter, periplasmic molybdate-binding protein
DPR03_RS07140	COG4149	molybdate abc transporter
DPR03_RS07145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DPR03_RS07150	COG2223	nitrite transmembrane transporter activity
DPR03_RS07160	COG0347	Belongs to the P(II) protein family
DPR03_RS07180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DPR03_RS07185	COG1309	transcriptional regulator
DPR03_RS07205	COG1944	ATP diphosphatase activity
DPR03_RS07220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DPR03_RS07235	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DPR03_RS07240	COG1877	trehalose-phosphatase activity
DPR03_RS07250	COG0583	DNA-binding transcription factor activity
DPR03_RS07260	COG0583	DNA-binding transcription factor activity
DPR03_RS07280	COG3845	ABC transporter
DPR03_RS07285	COG4603	Belongs to the binding-protein-dependent transport system permease family
DPR03_RS07290	COG1079	Belongs to the binding-protein-dependent transport system permease family
DPR03_RS07305	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DPR03_RS07310	COG2116	formate transmembrane transporter activity
DPR03_RS07320	COG0515	serine threonine protein kinase
DPR03_RS07340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DPR03_RS07345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DPR03_RS07365	COG0745	RESPONSE REGULATOR receiver
DPR03_RS07370	COG0642	Histidine kinase
DPR03_RS07385	COG4221	oxidoreductase activity
DPR03_RS07420	COG3550	peptidyl-serine autophosphorylation
DPR03_RS07430	COG2801	Transposase and inactivated derivatives
DPR03_RS07520	COG0596	Alpha beta hydrolase
DPR03_RS07550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DPR03_RS07555	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DPR03_RS07580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DPR03_RS07595	COG0439	Biotin carboxylase
DPR03_RS07605	COG3706	GGDEF domain
DPR03_RS07615	COG2814	Major facilitator Superfamily
DPR03_RS07660	COG1546	Belongs to the CinA family
DPR03_RS07660	COG1058	Belongs to the CinA family
DPR03_RS07670	COG0372	Belongs to the citrate synthase family
DPR03_RS07690	COG0477	Major facilitator Superfamily
DPR03_RS07705	COG0542	response to heat
DPR03_RS07710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DPR03_RS07750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DPR03_RS07755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DPR03_RS07760	COG0569	domain protein
DPR03_RS07765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DPR03_RS07785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DPR03_RS07795	COG1585	Membrane protein implicated in regulation of membrane protease activity
DPR03_RS07815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DPR03_RS07820	COG0776	regulation of translation
DPR03_RS07845	COG0822	iron-sulfur transferase activity
DPR03_RS07850	COG0316	Belongs to the HesB IscA family
DPR03_RS07880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DPR03_RS07890	COG1027	Aspartate ammonia-lyase
DPR03_RS07895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DPR03_RS07905	COG0506	proline dehydrogenase activity
DPR03_RS07905	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DPR03_RS07905	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DPR03_RS07925	COG3781	membrane
DPR03_RS07930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DPR03_RS07965	COG0697	spore germination
DPR03_RS07990	COG0424	maF-like protein
DPR03_RS08000	COG2850	peptidyl-arginine hydroxylation
DPR03_RS08005	COG0625	glutathione transferase activity
DPR03_RS08010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DPR03_RS08015	COG0702	epimerase
DPR03_RS08020	COG0268	Binds directly to 16S ribosomal RNA
DPR03_RS08035	COG1011	Hydrolase
DPR03_RS08040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DPR03_RS08050	COG2137	regulation of response to DNA damage stimulus
DPR03_RS08065	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DPR03_RS08070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DPR03_RS08075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DPR03_RS08085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DPR03_RS08100	COG0575	Belongs to the CDS family
DPR03_RS08105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DPR03_RS08125	COG3852	Histidine kinase
DPR03_RS08130	COG2204	response regulator
DPR03_RS08160	COG0445	tRNA wobble uridine modification
DPR03_RS08190	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DPR03_RS08195	COG0138	bifunctional purine biosynthesis protein purh
DPR03_RS08205	COG3328	transposase activity
DPR03_RS08220	COG1464	Belongs to the NlpA lipoprotein family
DPR03_RS08225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DPR03_RS08230	COG2011	ABC-type metal ion transport system permease component
DPR03_RS08260	COG3706	GGDEF domain
DPR03_RS08260	COG2203	Gaf domain
DPR03_RS08260	COG4251	negative regulation of phosphorylation
DPR03_RS08260	COG5001	Diguanylate cyclase
DPR03_RS08270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DPR03_RS08280	COG4122	O-methyltransferase activity
DPR03_RS08285	COG0589	response to stress
DPR03_RS08310	COG1538	Outer membrane efflux protein
DPR03_RS08315	COG1137	ATPase activity
DPR03_RS08320	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DPR03_RS08330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DPR03_RS08335	COG0517	IMP dehydrogenase activity
DPR03_RS08335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DPR03_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
DPR03_RS08380	COG0519	Catalyzes the synthesis of GMP from XMP
DPR03_RS08380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DPR03_RS08385	COG2353	YceI-like domain
DPR03_RS08390	COG0456	acetyltransferase
DPR03_RS08400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DPR03_RS08405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DPR03_RS08415	COG2391	methyltransferase activity
DPR03_RS08485	COG1309	transcriptional regulator
DPR03_RS08530	COG0352	thiamine-phosphate diphosphorylase activity
DPR03_RS08545	COG3025	triphosphatase activity
DPR03_RS08565	COG3618	amidohydrolase
DPR03_RS08570	COG0612	Peptidase, M16
DPR03_RS08580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DPR03_RS08585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DPR03_RS08635	COG2815	serine threonine protein kinase
DPR03_RS08635	COG0515	serine threonine protein kinase
DPR03_RS08690	COG4783	chaperone-mediated protein folding
DPR03_RS08745	COG0778	Nitroreductase
DPR03_RS08755	COG0513	Belongs to the DEAD box helicase family
DPR03_RS08760	COG1278	Cold shock
DPR03_RS08775	COG2363	Small membrane protein
DPR03_RS08800	COG2249	NAD(P)H dehydrogenase (quinone) activity
DPR03_RS08810	COG0659	secondary active sulfate transmembrane transporter activity
DPR03_RS08815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DPR03_RS08835	COG2885	chlorophyll binding
DPR03_RS08835	COG3047	cAMP biosynthetic process
DPR03_RS08845	COG0540	Belongs to the ATCase OTCase family
DPR03_RS08865	COG0667	Aldo Keto reductase
DPR03_RS08875	COG1765	OsmC-like protein
DPR03_RS08880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DPR03_RS08905	COG0281	malic enzyme
DPR03_RS08925	COG0714	Associated with various cellular activities
DPR03_RS08930	COG2879	small protein
DPR03_RS08935	COG1966	Carbon starvation protein
DPR03_RS08940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DPR03_RS08980	COG1067	ATP-dependent peptidase activity
DPR03_RS08985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DPR03_RS08990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DPR03_RS08995	COG0583	DNA-binding transcription factor activity
DPR03_RS09020	COG1686	Belongs to the peptidase S11 family
DPR03_RS09025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DPR03_RS09045	COG5002	protein histidine kinase activity
DPR03_RS09085	COG0616	signal peptide processing
DPR03_RS09095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DPR03_RS09105	COG0573	inorganic phosphate transmembrane transporter activity
DPR03_RS09115	COG0076	glutamate decarboxylase activity
DPR03_RS09120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DPR03_RS09130	COG0671	phosphoesterase, PA-phosphatase related
DPR03_RS09135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DPR03_RS09160	COG1733	regulation of RNA biosynthetic process
DPR03_RS09185	COG0556	nucleotide-excision repair
DPR03_RS09195	COG2199	diguanylate cyclase activity
DPR03_RS09225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DPR03_RS09230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DPR03_RS09235	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS09245	COG2084	Dehydrogenase
DPR03_RS09255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DPR03_RS09260	COG0251	oxidation-reduction process
DPR03_RS09265	COG1335	isochorismatase
DPR03_RS09270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DPR03_RS09275	COG0596	Alpha beta hydrolase
DPR03_RS09285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DPR03_RS09295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DPR03_RS09335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DPR03_RS09350	COG0174	glutamine synthetase
DPR03_RS09355	COG0512	Glutamine amidotransferase of anthranilate synthase
DPR03_RS09360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DPR03_RS09375	COG0302	gtp cyclohydrolase
DPR03_RS09390	COG3706	GGDEF domain
DPR03_RS09405	COG3739	integral membrane protein
DPR03_RS09420	COG1741	Belongs to the pirin family
DPR03_RS09455	COG0640	Transcriptional regulator
DPR03_RS09470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DPR03_RS09475	COG4232	protein-disulfide reductase activity
DPR03_RS09485	COG0642	Histidine kinase
DPR03_RS09500	COG1902	pentaerythritol trinitrate reductase activity
DPR03_RS09500	COG0446	pyridine nucleotide-disulphide oxidoreductase
DPR03_RS09510	COG0277	FAD linked oxidase domain protein
DPR03_RS09520	COG2186	Transcriptional regulator
DPR03_RS09525	COG1620	l-lactate permease
DPR03_RS09535	COG3706	GGDEF domain
DPR03_RS09535	COG4251	negative regulation of phosphorylation
DPR03_RS09535	COG5001	Diguanylate cyclase
DPR03_RS09535	COG2203	Gaf domain
DPR03_RS09540	COG0418	dihydroorotase activity
DPR03_RS09545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DPR03_RS09555	COG4771	TonB-dependent receptor
DPR03_RS09565	COG0833	amino acid
DPR03_RS09605	COG4172	Belongs to the ABC transporter superfamily
DPR03_RS09610	COG4239	(ABC) transporter, permease
DPR03_RS09615	COG4174	ABC transporter (Permease)
DPR03_RS09620	COG4166	transmembrane transport
DPR03_RS09625	COG1388	LysM domain
DPR03_RS09625	COG0741	lytic transglycosylase activity
DPR03_RS09645	COG0657	acetylesterase activity
DPR03_RS09675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DPR03_RS09680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DPR03_RS09700	COG2155	Conserved Protein
DPR03_RS09710	COG0006	proline dipeptidase activity
DPR03_RS09745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DPR03_RS09755	COG2234	aminopeptidase activity
DPR03_RS09765	COG3384	dioxygenase
DPR03_RS09775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DPR03_RS09780	COG2878	Part of a membrane complex involved in electron transport
DPR03_RS09785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DPR03_RS09810	COG0768	penicillin binding
DPR03_RS09815	COG0742	ribosomal rna small subunit methyltransferase
DPR03_RS09900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DPR03_RS09920	COG3321	synthase
DPR03_RS09920	COG0604	alcohol dehydrogenase
DPR03_RS09920	COG4221	oxidoreductase activity
DPR03_RS09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DPR03_RS09965	COG2268	Band 7 protein
DPR03_RS09970	COG1649	PFAM Uncharacterised BCR, COG1649
DPR03_RS09970	COG0726	polysaccharide deacetylase
DPR03_RS09980	COG1215	transferase activity, transferring glycosyl groups
DPR03_RS09985	COG1649	PFAM Uncharacterised BCR, COG1649
DPR03_RS09985	COG0726	polysaccharide deacetylase
DPR03_RS09995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DPR03_RS10005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DPR03_RS10020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DPR03_RS10025	COG1053	succinate dehydrogenase
DPR03_RS10030	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DPR03_RS10050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DPR03_RS10050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DPR03_RS10085	COG2321	neutral zinc metallopeptidase
DPR03_RS10090	COG2354	Protein conserved in bacteria
DPR03_RS10110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DPR03_RS10115	COG1773	rubredoxin
DPR03_RS10120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DPR03_RS10130	COG0583	DNA-binding transcription factor activity
DPR03_RS10140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DPR03_RS10150	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DPR03_RS10155	COG4181	ATPase activity
DPR03_RS10180	COG4771	TonB-dependent receptor
DPR03_RS10200	COG0306	phosphate transporter
DPR03_RS10230	COG2376	Dihydroxyacetone kinase
DPR03_RS10235	COG2066	Belongs to the glutaminase family
DPR03_RS10240	COG0300	oxidoreductase activity
DPR03_RS10250	COG0525	valine-tRNA ligase activity
DPR03_RS10260	COG2852	Protein conserved in bacteria
DPR03_RS10275	COG2323	membrane
DPR03_RS10280	COG0546	phosphoglycolate phosphatase activity
DPR03_RS10300	COG1752	Esterase of the alpha-beta hydrolase superfamily
DPR03_RS10315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DPR03_RS10320	COG0142	geranyltranstransferase activity
DPR03_RS10325	COG2828	Protein conserved in bacteria
DPR03_RS10330	COG1113	amino acid transport
DPR03_RS10360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DPR03_RS10365	COG1530	ribonuclease E activity
DPR03_RS10370	COG0424	maF-like protein
DPR03_RS10375	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DPR03_RS10380	COG1792	Involved in formation and maintenance of cell shape
DPR03_RS10385	COG1077	Cell shape determining protein MreB Mrl
DPR03_RS10390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DPR03_RS10400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DPR03_RS10425	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DPR03_RS10440	COG1294	oxidase, subunit
DPR03_RS10445	COG1271	oxidase subunit
DPR03_RS10465	COG4106	trans-aconitate 2-methyltransferase activity
DPR03_RS10480	COG0596	Alpha beta hydrolase
DPR03_RS10485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DPR03_RS10505	COG1113	amino acid transport
DPR03_RS10510	COG1448	Aminotransferase
DPR03_RS10525	COG0625	glutathione transferase activity
DPR03_RS10540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DPR03_RS10550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DPR03_RS10555	COG2050	protein possibly involved in aromatic compounds catabolism
DPR03_RS10580	COG0420	3'-5' exonuclease activity
DPR03_RS10610	COG0735	belongs to the Fur family
DPR03_RS10615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DPR03_RS10620	COG2914	Belongs to the UPF0125 (RnfH) family
DPR03_RS10635	COG0121	glutamine amidotransferase
DPR03_RS10645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DPR03_RS10650	COG0756	dUTP diphosphatase activity
DPR03_RS10660	COG2885	chlorophyll binding
DPR03_RS10665	COG0204	Acyl-transferase
DPR03_RS10695	COG0531	amino acid
DPR03_RS10695	COG1674	ftsk spoiiie
DPR03_RS10700	COG0492	ferredoxin-NADP+ reductase activity
DPR03_RS10705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DPR03_RS10715	COG0456	acetyltransferase
DPR03_RS10725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DPR03_RS10740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DPR03_RS10755	COG1981	membrane
DPR03_RS10760	COG1113	amino acid transport
DPR03_RS10765	COG0251	oxidation-reduction process
DPR03_RS10785	COG1652	LysM domain
DPR03_RS10790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DPR03_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
DPR03_RS10810	COG1399	metal-binding, possibly nucleic acid-binding protein
DPR03_RS10815	COG3101	peptidyl-lysine hydroxylation
DPR03_RS10820	COG0009	L-threonylcarbamoyladenylate synthase
DPR03_RS10840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DPR03_RS10845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DPR03_RS10860	COG2193	ferroxidase activity
DPR03_RS10865	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DPR03_RS10870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DPR03_RS10880	COG1196	nuclear chromosome segregation
DPR03_RS10890	COG0730	response to heat
DPR03_RS10895	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DPR03_RS10895	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DPR03_RS10905	COG3545	Serine hydrolase
DPR03_RS10915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DPR03_RS10940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DPR03_RS10950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DPR03_RS10965	COG4269	membrane
DPR03_RS10985	COG1968	undecaprenyl-diphosphatase activity
DPR03_RS10990	COG1214	PFAM Peptidase M22, glycoprotease
DPR03_RS11000	COG0494	nUDIX hydrolase
DPR03_RS11015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DPR03_RS11040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DPR03_RS11045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DPR03_RS11050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DPR03_RS11055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DPR03_RS11060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DPR03_RS11065	COG0625	glutathione transferase activity
DPR03_RS11070	COG2969	positive regulation of protein catabolic process
DPR03_RS11125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DPR03_RS11130	COG1764	response to oxidative stress
DPR03_RS11175	COG0037	tRNA processing
DPR03_RS11185	COG0248	Ppx GppA phosphatase
DPR03_RS11210	COG0072	phenylalanine-tRNA ligase activity
DPR03_RS11215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DPR03_RS11245	COG1238	metal cluster binding
DPR03_RS11255	COG0625	glutathione transferase activity
DPR03_RS11265	COG0546	phosphoglycolate phosphatase activity
DPR03_RS11290	COG0318	PFAM AMP-dependent synthetase and ligase
DPR03_RS11310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DPR03_RS11325	COG1442	glycosyl transferase family 8
DPR03_RS11335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DPR03_RS11335	COG0463	Glycosyl transferase, family 2
DPR03_RS11340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DPR03_RS11385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DPR03_RS11405	COG1660	Displays ATPase and GTPase activities
DPR03_RS11420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DPR03_RS11425	COG0617	tRNA 3'-terminal CCA addition
DPR03_RS11430	COG1555	photosystem II stabilization
DPR03_RS11435	COG3956	TIGRFAM MazG family protein
DPR03_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
DPR03_RS11455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DPR03_RS11465	COG0124	histidyl-tRNA synthetase
DPR03_RS11475	COG1426	Protein conserved in bacteria
DPR03_RS11495	COG2975	iron-sulfur cluster assembly
DPR03_RS11530	COG0440	acetolactate synthase activity
DPR03_RS11535	COG0028	Belongs to the TPP enzyme family
DPR03_RS11560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DPR03_RS11565	COG0577	efflux transmembrane transporter activity
DPR03_RS11565	COG1136	(ABC) transporter
DPR03_RS11570	COG1538	Outer membrane efflux protein
DPR03_RS11580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DPR03_RS11590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DPR03_RS11595	COG1162	GTPase activity
DPR03_RS11625	COG0084	hydrolase, TatD family'
DPR03_RS11640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DPR03_RS11650	COG1401	restriction endodeoxyribonuclease activity
DPR03_RS11675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DPR03_RS11685	COG1061	Type III restriction enzyme res subunit
DPR03_RS11690	COG1002	Type II restriction enzyme, methylase subunits
DPR03_RS11695	COG3293	Transposase
DPR03_RS11740	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DPR03_RS11750	COG0084	hydrolase, TatD family'
DPR03_RS11835	COG0793	Belongs to the peptidase S41A family
DPR03_RS11860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DPR03_RS11865	COG0857	belongs to the CobB CobQ family
DPR03_RS11865	COG0280	phosphate acetyltransferase
DPR03_RS11875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DPR03_RS11875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DPR03_RS11890	COG0740	serine-type endopeptidase activity
DPR03_RS11900	COG4774	siderophore transport
DPR03_RS11905	COG4774	siderophore transport
DPR03_RS11910	COG3128	pkhd-type hydroxylase
DPR03_RS11920	COG4774	siderophore transport
DPR03_RS11925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DPR03_RS11935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DPR03_RS11935	COG2813	Specifically methylates the guanine in position
DPR03_RS11985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DPR03_RS12025	COG0788	formyltetrahydrofolate deformylase activity
DPR03_RS12050	COG4651	solute:proton antiporter activity
DPR03_RS12050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DPR03_RS12065	COG0724	RNA recognition motif
DPR03_RS12070	COG0210	DNA helicase
DPR03_RS12075	COG1929	Belongs to the glycerate kinase type-1 family
DPR03_RS12105	COG2900	Belongs to the SlyX family
DPR03_RS12110	COG0488	(ABC) transporter
DPR03_RS12115	COG1560	Kdo2-lipid A biosynthetic process
DPR03_RS12145	COG0252	asparaginase activity
DPR03_RS12185	COG0473	3-isopropylmalate dehydrogenase activity
DPR03_RS12200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DPR03_RS12245	COG1960	acyl-CoA dehydrogenase activity
DPR03_RS12255	COG0753	catalase activity
DPR03_RS12270	COG0446	pyridine nucleotide-disulphide oxidoreductase
DPR03_RS12275	COG3384	dioxygenase
DPR03_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
DPR03_RS12295	COG4638	Rieske (2fe-2S)
DPR03_RS12300	COG0583	DNA-binding transcription factor activity
DPR03_RS12320	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DPR03_RS12325	COG3971	2-oxopent-4-enoate hydratase activity
DPR03_RS12330	COG0546	phosphoglycolate phosphatase activity
DPR03_RS12345	COG1530	ribonuclease E activity
DPR03_RS12350	COG0318	PFAM AMP-dependent synthetase and ligase
DPR03_RS12380	COG1983	PspC domain protein
DPR03_RS12390	COG0471	metal ion transport
DPR03_RS12405	COG0752	glycyl-tRNA synthetase alpha subunit
DPR03_RS12410	COG0751	glycine-tRNA ligase activity
DPR03_RS12435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DPR03_RS12465	COG0493	'glutamate synthase
DPR03_RS12475	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DPR03_RS12490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DPR03_RS12505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DPR03_RS12515	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DPR03_RS12515	COG0644	oxidoreductase
DPR03_RS12575	COG4535	Mg2 and Co2 transporter CorC
DPR03_RS12580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DPR03_RS12600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DPR03_RS12610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DPR03_RS12625	COG0789	Transcriptional regulator
DPR03_RS12630	COG2841	Protein conserved in bacteria
DPR03_RS12635	COG1185	polyribonucleotide nucleotidyltransferase activity
DPR03_RS12640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DPR03_RS12650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DPR03_RS12655	COG1074	ATP-dependent DNA helicase activity
DPR03_RS12660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DPR03_RS12695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DPR03_RS12730	COG0427	acetyl-CoA hydrolase
DPR03_RS12740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DPR03_RS12770	COG0326	Molecular chaperone. Has ATPase activity
DPR03_RS12785	COG2056	Na+-H+ antiporter family
DPR03_RS12815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DPR03_RS12820	COG0085	RNA polymerase activity
DPR03_RS12835	COG0081	regulation of translation
DPR03_RS12840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DPR03_RS12860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DPR03_RS12890	COG0546	phosphoglycolate phosphatase activity
DPR03_RS12920	COG0824	Thioesterase
DPR03_RS12940	COG0181	hydroxymethylbilane synthase activity
DPR03_RS12950	COG3275	phosphorelay sensor kinase activity
DPR03_RS12980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DPR03_RS12990	COG0322	excinuclease ABC activity
DPR03_RS13005	COG3706	GGDEF domain
DPR03_RS13010	COG1250	3-hydroxyacyl-CoA dehydrogenase
DPR03_RS13010	COG1024	Enoyl-CoA hydratase
DPR03_RS13070	COG0131	Imidazoleglycerol-phosphate dehydratase
DPR03_RS13075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DPR03_RS13120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DPR03_RS13125	COG0107	imidazoleglycerol-phosphate synthase activity
DPR03_RS13185	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DPR03_RS13215	COG2814	Major facilitator Superfamily
DPR03_RS13225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DPR03_RS13230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DPR03_RS13240	COG3328	transposase activity
DPR03_RS13275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DPR03_RS13285	COG3162	membrane
DPR03_RS13290	COG2205	protein histidine kinase activity
DPR03_RS13290	COG0784	Response regulator, receiver
DPR03_RS13305	COG0431	NADPH-dependent FMN reductase
DPR03_RS13315	COG0307	riboflavin synthase, alpha
DPR03_RS13330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DPR03_RS13340	COG0668	transmembrane transport
DPR03_RS13345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DPR03_RS13350	COG1519	Transferase
DPR03_RS13355	COG1902	pentaerythritol trinitrate reductase activity
DPR03_RS13360	COG0640	Transcriptional regulator
DPR03_RS13380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DPR03_RS13390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DPR03_RS13405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DPR03_RS13405	COG0426	domain, Protein
DPR03_RS13410	COG2119	membrane
DPR03_RS13445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DPR03_RS13455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DPR03_RS13470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DPR03_RS13480	COG0189	ligase activity
DPR03_RS13510	COG1278	Cold shock
DPR03_RS13520	COG0708	Exodeoxyribonuclease III
DPR03_RS13525	COG1393	Belongs to the ArsC family
DPR03_RS13540	COG3706	GGDEF domain
DPR03_RS13575	COG2351	hydroxyisourate hydrolase activity
DPR03_RS13580	COG2233	PERMEase
DPR03_RS13595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DPR03_RS13600	COG4266	Belongs to the allantoicase family
DPR03_RS13625	COG2205	protein histidine kinase activity
DPR03_RS13625	COG0784	Response regulator, receiver
DPR03_RS13650	COG0410	ABC transporter
DPR03_RS13655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DPR03_RS13680	COG3150	esterase
DPR03_RS13695	COG2918	glutathione biosynthetic process
DPR03_RS13710	COG2733	membrane
DPR03_RS13750	COG0753	catalase activity
DPR03_RS13770	COG3830	Belongs to the UPF0237 family
DPR03_RS13770	COG0560	Phosphoserine phosphatase
DPR03_RS13780	COG0385	Bile acid
DPR03_RS13785	COG1335	isochorismatase
DPR03_RS13790	COG2814	Major facilitator Superfamily
DPR03_RS13795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DPR03_RS13805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DPR03_RS13820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DPR03_RS13825	COG5001	Diguanylate cyclase
DPR03_RS13825	COG3300	MHYT domain
DPR03_RS13830	COG2983	Belongs to the UPF0260 family
DPR03_RS13835	COG5487	UPF0391 membrane protein
DPR03_RS13840	COG0728	peptidoglycan biosynthetic process
DPR03_RS13845	COG3023	N-Acetylmuramoyl-L-alanine amidase
DPR03_RS13855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DPR03_RS13860	COG1309	transcriptional regulator
DPR03_RS13865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DPR03_RS13870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DPR03_RS13875	COG0546	phosphoglycolate phosphatase activity
DPR03_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
DPR03_RS13905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DPR03_RS13905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DPR03_RS13910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DPR03_RS13915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DPR03_RS13920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DPR03_RS13925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DPR03_RS13930	COG1116	anion transmembrane transporter activity
DPR03_RS13935	COG1309	transcriptional regulator
DPR03_RS13945	COG0196	riboflavin kinase activity
DPR03_RS13950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DPR03_RS13960	COG1047	Peptidyl-prolyl cis-trans
DPR03_RS13970	COG2133	pyrroloquinoline quinone binding
DPR03_RS14005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DPR03_RS14010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DPR03_RS14015	COG2951	lytic endotransglycosylase activity
DPR03_RS14020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DPR03_RS14040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DPR03_RS14070	COG2388	GCN5-related N-acetyl-transferase
DPR03_RS14075	COG2814	Major facilitator Superfamily
DPR03_RS14080	COG0861	Integral membrane protein TerC family
DPR03_RS14085	COG0402	S-adenosylhomocysteine deaminase activity
DPR03_RS14240	COG0582	viral genome integration into host DNA
DPR03_RS14250	COG0706	membrane insertase activity
DPR03_RS14255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DPR03_RS14260	COG0594	ribonuclease P activity
DPR03_RS14310	COG0659	secondary active sulfate transmembrane transporter activity
DPR03_RS14315	COG0589	response to stress
DPR03_RS14325	COG0492	ferredoxin-NADP+ reductase activity
DPR03_RS14330	COG0431	NADPH-dependent FMN reductase
DPR03_RS14335	COG0798	PFAM Bile acid sodium symporter
DPR03_RS14345	COG0640	Transcriptional regulator
DPR03_RS14355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DPR03_RS14405	COG0789	Transcriptional regulator
DPR03_RS14435	COG4372	Transposase
DPR03_RS14495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DPR03_RS14520	COG2369	cell adhesion
DPR03_RS14525	COG0582	viral genome integration into host DNA
DPR03_RS14550	COG0789	Transcriptional regulator
DPR03_RS14600	COG2223	nitrite transmembrane transporter activity
DPR03_RS14660	COG2217	Heavy metal translocating P-type atpase
DPR03_RS14665	COG3174	membrane
DPR03_RS14670	COG2205	protein histidine kinase activity
DPR03_RS14685	COG2132	Multicopper oxidase
DPR03_RS14760	COG2132	Multicopper oxidase
DPR03_RS14775	COG3077	Addiction module antitoxin, RelB DinJ family
DPR03_RS14825	COG2009	succinate dehydrogenase
DPR03_RS14845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DPR03_RS14865	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DPR03_RS14905	COG0625	glutathione transferase activity
DPR03_RS14910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DPR03_RS14950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DPR03_RS14985	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
DPR03_RS15035	COG0583	DNA-binding transcription factor activity
DPR03_RS15040	COG0604	alcohol dehydrogenase
DPR03_RS15040	COG3321	synthase
DPR03_RS15045	COG3321	synthase
DPR03_RS15045	COG0604	alcohol dehydrogenase
DPR03_RS15060	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DPR03_RS15120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DPR03_RS15130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DPR03_RS15135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DPR03_RS15200	COG3550	peptidyl-serine autophosphorylation
DPR03_RS15205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DPR03_RS15215	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DPR03_RS15215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DPR03_RS15215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DPR03_RS15220	COG1105	Belongs to the carbohydrate kinase PfkB family
DPR03_RS15225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DPR03_RS15225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DPR03_RS15240	COG2267	carboxylic ester hydrolase activity
DPR03_RS15240	COG2226	methyltransferase
DPR03_RS15265	COG4773	Receptor
DPR03_RS15295	COG1454	alcohol dehydrogenase
DPR03_RS15315	COG4774	siderophore transport
DPR03_RS15320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DPR03_RS15365	COG1192	Involved in chromosome partitioning
DPR03_RS15430	COG1373	ATPase (AAA superfamily
DPR03_RS15525	COG1764	response to oxidative stress
DPR03_RS15530	COG1846	Transcriptional regulator
DPR03_RS15625	COG1764	response to oxidative stress
DPR03_RS15630	COG1846	Transcriptional regulator