locus-tag	class	description
FSC12_RS00025	COG0864	Transcriptional regulator
FSC12_RS00060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FSC12_RS00065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FSC12_RS00070	COG1116	anion transmembrane transporter activity
FSC12_RS00070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FSC12_RS00080	COG2223	nitrite transmembrane transporter activity
FSC12_RS00085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FSC12_RS00090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FSC12_RS00095	COG0243	molybdopterin cofactor binding
FSC12_RS00105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FSC12_RS00115	COG0314	molybdopterin synthase activity
FSC12_RS00120	COG0521	Mo-molybdopterin cofactor biosynthetic process
FSC12_RS00120	COG0315	cyclic pyranopterin monophosphate synthase activity
FSC12_RS00125	COG0303	'Molybdopterin
FSC12_RS00130	COG0725	ABC transporter, periplasmic molybdate-binding protein
FSC12_RS00135	COG4149	molybdate abc transporter
FSC12_RS00140	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FSC12_RS00145	COG2223	nitrite transmembrane transporter activity
FSC12_RS00155	COG0347	Belongs to the P(II) protein family
FSC12_RS00175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FSC12_RS00180	COG1309	transcriptional regulator
FSC12_RS00200	COG1944	ATP diphosphatase activity
FSC12_RS00215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FSC12_RS00230	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FSC12_RS00235	COG1877	trehalose-phosphatase activity
FSC12_RS00245	COG0583	DNA-binding transcription factor activity
FSC12_RS00255	COG0583	DNA-binding transcription factor activity
FSC12_RS00300	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FSC12_RS00305	COG2116	formate transmembrane transporter activity
FSC12_RS00310	COG0515	serine threonine protein kinase
FSC12_RS00330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FSC12_RS00335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FSC12_RS00350	COG2194	sulfuric ester hydrolase activity
FSC12_RS00355	COG0745	RESPONSE REGULATOR receiver
FSC12_RS00360	COG0642	Histidine kinase
FSC12_RS00375	COG4221	oxidoreductase activity
FSC12_RS00410	COG3550	peptidyl-serine autophosphorylation
FSC12_RS00500	COG0596	Alpha beta hydrolase
FSC12_RS00530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FSC12_RS00535	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FSC12_RS00560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FSC12_RS00575	COG0439	Biotin carboxylase
FSC12_RS00585	COG3706	GGDEF domain
FSC12_RS00625	COG1058	Belongs to the CinA family
FSC12_RS00625	COG1546	Belongs to the CinA family
FSC12_RS00635	COG0372	Belongs to the citrate synthase family
FSC12_RS00655	COG0477	Major facilitator Superfamily
FSC12_RS00670	COG0542	response to heat
FSC12_RS00675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FSC12_RS00700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FSC12_RS00710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FSC12_RS00715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FSC12_RS00720	COG0569	domain protein
FSC12_RS00725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FSC12_RS00745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FSC12_RS00755	COG1585	Membrane protein implicated in regulation of membrane protease activity
FSC12_RS00775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FSC12_RS00780	COG0776	regulation of translation
FSC12_RS00805	COG0822	iron-sulfur transferase activity
FSC12_RS00810	COG0316	Belongs to the HesB IscA family
FSC12_RS00840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FSC12_RS00850	COG1027	Aspartate ammonia-lyase
FSC12_RS00855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FSC12_RS00870	COG0506	proline dehydrogenase activity
FSC12_RS00870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FSC12_RS00870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FSC12_RS00890	COG3781	membrane
FSC12_RS00895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FSC12_RS00925	COG0697	spore germination
FSC12_RS00950	COG0424	maF-like protein
FSC12_RS00960	COG2850	peptidyl-arginine hydroxylation
FSC12_RS00965	COG0625	glutathione transferase activity
FSC12_RS00970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FSC12_RS00975	COG0702	epimerase
FSC12_RS00980	COG0268	Binds directly to 16S ribosomal RNA
FSC12_RS00995	COG1011	Hydrolase
FSC12_RS01000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FSC12_RS01010	COG2137	regulation of response to DNA damage stimulus
FSC12_RS01025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FSC12_RS01030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FSC12_RS01035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FSC12_RS01045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FSC12_RS01060	COG0575	Belongs to the CDS family
FSC12_RS01065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FSC12_RS01085	COG3852	Histidine kinase
FSC12_RS01100	COG2814	Major facilitator Superfamily
FSC12_RS01105	COG0445	tRNA wobble uridine modification
FSC12_RS01135	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FSC12_RS01140	COG0138	bifunctional purine biosynthesis protein purh
FSC12_RS01145	COG0151	Belongs to the GarS family
FSC12_RS01160	COG1464	Belongs to the NlpA lipoprotein family
FSC12_RS01165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FSC12_RS01170	COG2011	ABC-type metal ion transport system permease component
FSC12_RS01205	COG2203	Gaf domain
FSC12_RS01205	COG3706	GGDEF domain
FSC12_RS01205	COG4251	negative regulation of phosphorylation
FSC12_RS01205	COG5001	Diguanylate cyclase
FSC12_RS01215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FSC12_RS01225	COG4122	O-methyltransferase activity
FSC12_RS01230	COG0589	response to stress
FSC12_RS01255	COG1538	Outer membrane efflux protein
FSC12_RS01260	COG1137	ATPase activity
FSC12_RS01265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FSC12_RS01275	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FSC12_RS01280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FSC12_RS01280	COG0517	IMP dehydrogenase activity
FSC12_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS01320	COG0519	Catalyzes the synthesis of GMP from XMP
FSC12_RS01320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FSC12_RS01330	COG2353	YceI-like domain
FSC12_RS01345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FSC12_RS01350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FSC12_RS01365	COG2391	methyltransferase activity
FSC12_RS01445	COG1309	transcriptional regulator
FSC12_RS01510	COG0352	thiamine-phosphate diphosphorylase activity
FSC12_RS01525	COG3025	triphosphatase activity
FSC12_RS01545	COG3618	amidohydrolase
FSC12_RS01550	COG0612	Peptidase, M16
FSC12_RS01560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FSC12_RS01565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FSC12_RS01625	COG0515	serine threonine protein kinase
FSC12_RS01625	COG2815	serine threonine protein kinase
FSC12_RS01680	COG4783	chaperone-mediated protein folding
FSC12_RS01735	COG0778	Nitroreductase
FSC12_RS01745	COG0513	Belongs to the DEAD box helicase family
FSC12_RS01750	COG1278	Cold shock
FSC12_RS01765	COG2363	Small membrane protein
FSC12_RS01790	COG0625	glutathione transferase activity
FSC12_RS01795	COG0659	secondary active sulfate transmembrane transporter activity
FSC12_RS01800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FSC12_RS01805	COG0582	viral genome integration into host DNA
FSC12_RS01865	COG3047	cAMP biosynthetic process
FSC12_RS01865	COG2885	chlorophyll binding
FSC12_RS01875	COG0540	Belongs to the ATCase OTCase family
FSC12_RS01895	COG0667	Aldo Keto reductase
FSC12_RS01905	COG1765	OsmC-like protein
FSC12_RS01910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FSC12_RS01935	COG1136	(ABC) transporter
FSC12_RS01940	COG4591	ABC-type transport system involved in lipoprotein release permease component
FSC12_RS01945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FSC12_RS01950	COG0281	malic enzyme
FSC12_RS01975	COG0714	Associated with various cellular activities
FSC12_RS01980	COG2879	small protein
FSC12_RS01985	COG1966	Carbon starvation protein
FSC12_RS01990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FSC12_RS02030	COG1067	ATP-dependent peptidase activity
FSC12_RS02035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FSC12_RS02040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FSC12_RS02045	COG0583	DNA-binding transcription factor activity
FSC12_RS02070	COG1686	Belongs to the peptidase S11 family
FSC12_RS02075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FSC12_RS02090	COG2351	hydroxyisourate hydrolase activity
FSC12_RS02105	COG5002	protein histidine kinase activity
FSC12_RS02145	COG0616	signal peptide processing
FSC12_RS02155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FSC12_RS02165	COG0573	inorganic phosphate transmembrane transporter activity
FSC12_RS02180	COG0076	glutamate decarboxylase activity
FSC12_RS02185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FSC12_RS02195	COG0671	phosphoesterase, PA-phosphatase related
FSC12_RS02270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FSC12_RS02280	COG2814	Major facilitator Superfamily
FSC12_RS02290	COG1733	regulation of RNA biosynthetic process
FSC12_RS02315	COG0556	nucleotide-excision repair
FSC12_RS02365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FSC12_RS02370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FSC12_RS02375	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS02385	COG2084	Dehydrogenase
FSC12_RS02390	COG2233	PERMEase
FSC12_RS02395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FSC12_RS02400	COG0251	oxidation-reduction process
FSC12_RS02405	COG1335	isochorismatase
FSC12_RS02410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FSC12_RS02415	COG0596	Alpha beta hydrolase
FSC12_RS02425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FSC12_RS02435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FSC12_RS02475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FSC12_RS02480	COG3161	chorismate lyase activity
FSC12_RS02490	COG0174	glutamine synthetase
FSC12_RS02495	COG0512	Glutamine amidotransferase of anthranilate synthase
FSC12_RS02500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FSC12_RS02515	COG0302	gtp cyclohydrolase
FSC12_RS02530	COG3706	GGDEF domain
FSC12_RS02545	COG3739	integral membrane protein
FSC12_RS02570	COG0446	pyridine nucleotide-disulphide oxidoreductase
FSC12_RS02570	COG1902	pentaerythritol trinitrate reductase activity
FSC12_RS02580	COG0277	FAD linked oxidase domain protein
FSC12_RS02590	COG2186	Transcriptional regulator
FSC12_RS02595	COG1620	l-lactate permease
FSC12_RS02610	COG2203	Gaf domain
FSC12_RS02610	COG5001	Diguanylate cyclase
FSC12_RS02610	COG4251	negative regulation of phosphorylation
FSC12_RS02610	COG3706	GGDEF domain
FSC12_RS02615	COG0418	dihydroorotase activity
FSC12_RS02620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FSC12_RS02630	COG4771	TonB-dependent receptor
FSC12_RS02640	COG0833	amino acid
FSC12_RS02680	COG4172	Belongs to the ABC transporter superfamily
FSC12_RS02685	COG4239	(ABC) transporter, permease
FSC12_RS02690	COG4174	ABC transporter (Permease)
FSC12_RS02695	COG4166	transmembrane transport
FSC12_RS02700	COG1388	LysM domain
FSC12_RS02700	COG0741	lytic transglycosylase activity
FSC12_RS02750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FSC12_RS02755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FSC12_RS02805	COG2155	Conserved Protein
FSC12_RS02820	COG0006	proline dipeptidase activity
FSC12_RS02855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FSC12_RS02865	COG2234	aminopeptidase activity
FSC12_RS02875	COG3384	dioxygenase
FSC12_RS02885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FSC12_RS02890	COG2878	Part of a membrane complex involved in electron transport
FSC12_RS02895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FSC12_RS02920	COG0768	penicillin binding
FSC12_RS02925	COG0742	ribosomal rna small subunit methyltransferase
FSC12_RS03005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FSC12_RS03025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FSC12_RS03025	COG3321	synthase
FSC12_RS03025	COG4221	oxidoreductase activity
FSC12_RS03025	COG0604	alcohol dehydrogenase
FSC12_RS03070	COG2268	Band 7 protein
FSC12_RS03075	COG0726	polysaccharide deacetylase
FSC12_RS03075	COG1649	PFAM Uncharacterised BCR, COG1649
FSC12_RS03085	COG1215	transferase activity, transferring glycosyl groups
FSC12_RS03090	COG0726	polysaccharide deacetylase
FSC12_RS03090	COG1649	PFAM Uncharacterised BCR, COG1649
FSC12_RS03100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FSC12_RS03110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FSC12_RS03125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FSC12_RS03130	COG1053	succinate dehydrogenase
FSC12_RS03135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FSC12_RS03155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FSC12_RS03155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FSC12_RS03190	COG2321	neutral zinc metallopeptidase
FSC12_RS03195	COG2354	Protein conserved in bacteria
FSC12_RS03215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FSC12_RS03220	COG1773	rubredoxin
FSC12_RS03225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FSC12_RS03235	COG0583	DNA-binding transcription factor activity
FSC12_RS03245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FSC12_RS03255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FSC12_RS03260	COG4181	ATPase activity
FSC12_RS03285	COG0500	methyltransferase
FSC12_RS03290	COG4771	TonB-dependent receptor
FSC12_RS03310	COG0306	phosphate transporter
FSC12_RS03335	COG2376	Dihydroxyacetone kinase
FSC12_RS03340	COG2066	Belongs to the glutaminase family
FSC12_RS03345	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS03355	COG0525	valine-tRNA ligase activity
FSC12_RS03380	COG2323	membrane
FSC12_RS03385	COG0546	phosphoglycolate phosphatase activity
FSC12_RS03410	COG1752	Esterase of the alpha-beta hydrolase superfamily
FSC12_RS03425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FSC12_RS03435	COG0142	geranyltranstransferase activity
FSC12_RS03440	COG2828	Protein conserved in bacteria
FSC12_RS03445	COG1113	amino acid transport
FSC12_RS03475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FSC12_RS03480	COG1530	ribonuclease E activity
FSC12_RS03485	COG0424	maF-like protein
FSC12_RS03490	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FSC12_RS03495	COG1792	Involved in formation and maintenance of cell shape
FSC12_RS03500	COG1077	Cell shape determining protein MreB Mrl
FSC12_RS03505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FSC12_RS03515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FSC12_RS03530	COG0471	metal ion transport
FSC12_RS03545	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FSC12_RS03560	COG1294	oxidase, subunit
FSC12_RS03565	COG1271	oxidase subunit
FSC12_RS03585	COG4106	trans-aconitate 2-methyltransferase activity
FSC12_RS03600	COG0596	Alpha beta hydrolase
FSC12_RS03605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FSC12_RS03625	COG1113	amino acid transport
FSC12_RS03630	COG1448	Aminotransferase
FSC12_RS03645	COG0625	glutathione transferase activity
FSC12_RS03660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FSC12_RS03680	COG4716	Myosin-crossreactive antigen
FSC12_RS03750	COG1785	Belongs to the alkaline phosphatase family
FSC12_RS03755	COG1785	Belongs to the alkaline phosphatase family
FSC12_RS03780	COG1215	transferase activity, transferring glycosyl groups
FSC12_RS03795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FSC12_RS03850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FSC12_RS03855	COG2050	protein possibly involved in aromatic compounds catabolism
FSC12_RS03865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FSC12_RS03880	COG0420	3'-5' exonuclease activity
FSC12_RS03910	COG0735	belongs to the Fur family
FSC12_RS03915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FSC12_RS03920	COG2914	Belongs to the UPF0125 (RnfH) family
FSC12_RS03935	COG0121	glutamine amidotransferase
FSC12_RS03945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FSC12_RS03950	COG0756	dUTP diphosphatase activity
FSC12_RS03960	COG2885	chlorophyll binding
FSC12_RS03965	COG0204	Acyl-transferase
FSC12_RS03995	COG1674	ftsk spoiiie
FSC12_RS03995	COG0531	amino acid
FSC12_RS04000	COG0492	ferredoxin-NADP+ reductase activity
FSC12_RS04005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FSC12_RS04015	COG0456	acetyltransferase
FSC12_RS04025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FSC12_RS04030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FSC12_RS04040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FSC12_RS04060	COG1113	amino acid transport
FSC12_RS04065	COG0251	oxidation-reduction process
FSC12_RS04085	COG1652	LysM domain
FSC12_RS04090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FSC12_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS04110	COG1399	metal-binding, possibly nucleic acid-binding protein
FSC12_RS04115	COG3101	peptidyl-lysine hydroxylation
FSC12_RS04120	COG0009	L-threonylcarbamoyladenylate synthase
FSC12_RS04140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FSC12_RS04145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FSC12_RS04160	COG2193	ferroxidase activity
FSC12_RS04165	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FSC12_RS04170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FSC12_RS04180	COG1196	nuclear chromosome segregation
FSC12_RS04190	COG0730	response to heat
FSC12_RS04195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FSC12_RS04195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FSC12_RS04205	COG3545	Serine hydrolase
FSC12_RS04210	COG3545	Serine hydrolase
FSC12_RS04215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FSC12_RS04240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FSC12_RS04250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FSC12_RS04265	COG4269	membrane
FSC12_RS04285	COG1968	undecaprenyl-diphosphatase activity
FSC12_RS04290	COG1214	PFAM Peptidase M22, glycoprotease
FSC12_RS04300	COG0494	nUDIX hydrolase
FSC12_RS04315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FSC12_RS04340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FSC12_RS04345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FSC12_RS04350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FSC12_RS04355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FSC12_RS04360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FSC12_RS04365	COG0625	glutathione transferase activity
FSC12_RS04370	COG2969	positive regulation of protein catabolic process
FSC12_RS04420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FSC12_RS04425	COG1764	response to oxidative stress
FSC12_RS04475	COG0037	tRNA processing
FSC12_RS04485	COG0248	Ppx GppA phosphatase
FSC12_RS04510	COG0072	phenylalanine-tRNA ligase activity
FSC12_RS04515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FSC12_RS04545	COG1238	metal cluster binding
FSC12_RS04555	COG0625	glutathione transferase activity
FSC12_RS04570	COG0546	phosphoglycolate phosphatase activity
FSC12_RS04610	COG0318	PFAM AMP-dependent synthetase and ligase
FSC12_RS04635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FSC12_RS04650	COG1216	Glycosyl transferase, family 2
FSC12_RS04675	COG1091	dTDP-4-dehydrorhamnose reductase activity
FSC12_RS04725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FSC12_RS04745	COG1660	Displays ATPase and GTPase activities
FSC12_RS04760	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FSC12_RS04765	COG0617	tRNA 3'-terminal CCA addition
FSC12_RS04770	COG1555	photosystem II stabilization
FSC12_RS04775	COG3956	TIGRFAM MazG family protein
FSC12_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS04795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FSC12_RS04805	COG0124	histidyl-tRNA synthetase
FSC12_RS04815	COG1426	Protein conserved in bacteria
FSC12_RS04835	COG2975	iron-sulfur cluster assembly
FSC12_RS04870	COG0440	acetolactate synthase activity
FSC12_RS04875	COG0028	Belongs to the TPP enzyme family
FSC12_RS04900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FSC12_RS04905	COG0577	efflux transmembrane transporter activity
FSC12_RS04905	COG1136	(ABC) transporter
FSC12_RS04910	COG1538	Outer membrane efflux protein
FSC12_RS04920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FSC12_RS04930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FSC12_RS04935	COG1162	GTPase activity
FSC12_RS04965	COG0084	hydrolase, TatD family'
FSC12_RS04980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FSC12_RS05005	COG0793	Belongs to the peptidase S41A family
FSC12_RS05030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FSC12_RS05035	COG0857	belongs to the CobB CobQ family
FSC12_RS05035	COG0280	phosphate acetyltransferase
FSC12_RS05040	COG2610	gluconate transmembrane transporter activity
FSC12_RS05045	COG1454	alcohol dehydrogenase
FSC12_RS05055	COG1414	Transcriptional regulator
FSC12_RS05065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FSC12_RS05065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FSC12_RS05085	COG0740	serine-type endopeptidase activity
FSC12_RS05095	COG4771	TonB-dependent receptor
FSC12_RS05100	COG4774	siderophore transport
FSC12_RS05105	COG4774	siderophore transport
FSC12_RS05110	COG3128	pkhd-type hydroxylase
FSC12_RS05135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FSC12_RS05145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FSC12_RS05145	COG2813	Specifically methylates the guanine in position
FSC12_RS05195	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FSC12_RS05210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FSC12_RS05220	COG0411	ABC transporter
FSC12_RS05240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FSC12_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS05260	COG4638	Rieske (2fe-2S)
FSC12_RS05280	COG0154	amidase activity
FSC12_RS05290	COG0583	DNA-binding transcription factor activity
FSC12_RS05295	COG4948	Mandelate Racemase Muconate Lactonizing
FSC12_RS05300	COG4829	muconolactone delta-isomerase
FSC12_RS05315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FSC12_RS05320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FSC12_RS05325	COG0183	Belongs to the thiolase family
FSC12_RS05330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FSC12_RS05340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FSC12_RS05380	COG0788	formyltetrahydrofolate deformylase activity
FSC12_RS05405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FSC12_RS05405	COG4651	solute:proton antiporter activity
FSC12_RS05425	COG0724	RNA recognition motif
FSC12_RS05430	COG0210	DNA helicase
FSC12_RS05435	COG1929	Belongs to the glycerate kinase type-1 family
FSC12_RS05465	COG2900	Belongs to the SlyX family
FSC12_RS05475	COG1560	Kdo2-lipid A biosynthetic process
FSC12_RS05510	COG0252	asparaginase activity
FSC12_RS05540	COG0473	3-isopropylmalate dehydrogenase activity
FSC12_RS05555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FSC12_RS05610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FSC12_RS05620	COG0519	Catalyzes the synthesis of GMP from XMP
FSC12_RS05635	COG0446	pyridine nucleotide-disulphide oxidoreductase
FSC12_RS05640	COG3384	dioxygenase
FSC12_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS05660	COG4638	Rieske (2fe-2S)
FSC12_RS05665	COG0583	DNA-binding transcription factor activity
FSC12_RS05695	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FSC12_RS05700	COG3971	2-oxopent-4-enoate hydratase activity
FSC12_RS05705	COG0546	phosphoglycolate phosphatase activity
FSC12_RS05715	COG1530	ribonuclease E activity
FSC12_RS05720	COG0318	PFAM AMP-dependent synthetase and ligase
FSC12_RS05745	COG1983	PspC domain protein
FSC12_RS05755	COG0471	metal ion transport
FSC12_RS05775	COG0751	glycine-tRNA ligase activity
FSC12_RS05810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FSC12_RS05840	COG0493	'glutamate synthase
FSC12_RS05850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FSC12_RS05865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FSC12_RS05880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FSC12_RS05890	COG0644	oxidoreductase
FSC12_RS05890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FSC12_RS05905	COG3501	Rhs element vgr protein
FSC12_RS05915	COG4535	Mg2 and Co2 transporter CorC
FSC12_RS05920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FSC12_RS05940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FSC12_RS05950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FSC12_RS05965	COG0789	Transcriptional regulator
FSC12_RS05970	COG2841	Protein conserved in bacteria
FSC12_RS05975	COG1185	polyribonucleotide nucleotidyltransferase activity
FSC12_RS05980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FSC12_RS05985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FSC12_RS05990	COG1074	ATP-dependent DNA helicase activity
FSC12_RS05995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FSC12_RS06030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FSC12_RS06050	COG0745	RESPONSE REGULATOR receiver
FSC12_RS06055	COG2205	protein histidine kinase activity
FSC12_RS06060	COG0427	acetyl-CoA hydrolase
FSC12_RS06070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FSC12_RS06095	COG0326	Molecular chaperone. Has ATPase activity
FSC12_RS06110	COG2056	Na+-H+ antiporter family
FSC12_RS06140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FSC12_RS06145	COG0085	RNA polymerase activity
FSC12_RS06160	COG0081	regulation of translation
FSC12_RS06165	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FSC12_RS06185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FSC12_RS06215	COG0546	phosphoglycolate phosphatase activity
FSC12_RS06245	COG0824	Thioesterase
FSC12_RS06265	COG0181	hydroxymethylbilane synthase activity
FSC12_RS06275	COG3275	phosphorelay sensor kinase activity
FSC12_RS06290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FSC12_RS06300	COG0322	excinuclease ABC activity
FSC12_RS06315	COG3706	GGDEF domain
FSC12_RS06320	COG1250	3-hydroxyacyl-CoA dehydrogenase
FSC12_RS06320	COG1024	Enoyl-CoA hydratase
FSC12_RS06380	COG0131	Imidazoleglycerol-phosphate dehydratase
FSC12_RS06385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FSC12_RS06430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FSC12_RS06435	COG0107	imidazoleglycerol-phosphate synthase activity
FSC12_RS06465	COG3158	transport of potassium into the cell
FSC12_RS06495	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FSC12_RS06525	COG2814	Major facilitator Superfamily
FSC12_RS06535	COG0352	thiamine-phosphate diphosphorylase activity
FSC12_RS06535	COG0351	phosphomethylpyrimidine kinase
FSC12_RS06535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FSC12_RS06540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FSC12_RS06545	COG3706	GGDEF domain
FSC12_RS06575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FSC12_RS06580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FSC12_RS06585	COG3162	membrane
FSC12_RS06590	COG0784	Response regulator, receiver
FSC12_RS06590	COG2205	protein histidine kinase activity
FSC12_RS06615	COG0307	riboflavin synthase, alpha
FSC12_RS06630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FSC12_RS06640	COG0668	transmembrane transport
FSC12_RS06645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FSC12_RS06650	COG1519	Transferase
FSC12_RS06655	COG1902	pentaerythritol trinitrate reductase activity
FSC12_RS06660	COG0640	Transcriptional regulator
FSC12_RS06680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FSC12_RS06690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FSC12_RS06705	COG0426	domain, Protein
FSC12_RS06705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FSC12_RS06710	COG2119	membrane
FSC12_RS06740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FSC12_RS06750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FSC12_RS06765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FSC12_RS06775	COG0189	ligase activity
FSC12_RS06790	COG2132	Multicopper oxidase
FSC12_RS06810	COG3385	transposase activity
FSC12_RS06820	COG0708	Exodeoxyribonuclease III
FSC12_RS06825	COG1393	Belongs to the ArsC family
FSC12_RS06875	COG2351	hydroxyisourate hydrolase activity
FSC12_RS06880	COG2233	PERMEase
FSC12_RS06895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FSC12_RS06900	COG4266	Belongs to the allantoicase family
FSC12_RS06925	COG0784	Response regulator, receiver
FSC12_RS06925	COG2205	protein histidine kinase activity
FSC12_RS06950	COG0410	ABC transporter
FSC12_RS06980	COG3150	esterase
FSC12_RS06995	COG2918	glutathione biosynthetic process
FSC12_RS07010	COG2733	membrane
FSC12_RS07050	COG0753	catalase activity
FSC12_RS07070	COG0560	Phosphoserine phosphatase
FSC12_RS07070	COG3830	Belongs to the UPF0237 family
FSC12_RS07080	COG0385	Bile acid
FSC12_RS07085	COG1335	isochorismatase
FSC12_RS07090	COG2814	Major facilitator Superfamily
FSC12_RS07095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FSC12_RS07105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FSC12_RS07120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FSC12_RS07125	COG3300	MHYT domain
FSC12_RS07125	COG5001	Diguanylate cyclase
FSC12_RS07130	COG2983	Belongs to the UPF0260 family
FSC12_RS07135	COG5487	UPF0391 membrane protein
FSC12_RS07140	COG0728	peptidoglycan biosynthetic process
FSC12_RS07145	COG3023	N-Acetylmuramoyl-L-alanine amidase
FSC12_RS07155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FSC12_RS07160	COG1309	transcriptional regulator
FSC12_RS07165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FSC12_RS07170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FSC12_RS07175	COG0546	phosphoglycolate phosphatase activity
FSC12_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS07200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FSC12_RS07200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FSC12_RS07205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FSC12_RS07210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FSC12_RS07215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FSC12_RS07220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FSC12_RS07225	COG1116	anion transmembrane transporter activity
FSC12_RS07230	COG1309	transcriptional regulator
FSC12_RS07240	COG0196	riboflavin kinase activity
FSC12_RS07245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FSC12_RS07255	COG1047	Peptidyl-prolyl cis-trans
FSC12_RS07265	COG2133	pyrroloquinoline quinone binding
FSC12_RS07295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FSC12_RS07360	COG0488	(ABC) transporter
FSC12_RS07365	COG1063	alcohol dehydrogenase
FSC12_RS07375	COG0187	DNA topoisomerase II activity
FSC12_RS07385	COG0592	DNA-directed DNA polymerase activity
FSC12_RS07400	COG0594	ribonuclease P activity
FSC12_RS07405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FSC12_RS07410	COG0706	membrane insertase activity
FSC12_RS07450	COG0402	S-adenosylhomocysteine deaminase activity
FSC12_RS07455	COG0861	Integral membrane protein TerC family
FSC12_RS07460	COG2814	Major facilitator Superfamily
FSC12_RS07465	COG2388	GCN5-related N-acetyl-transferase
FSC12_RS07490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FSC12_RS07510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FSC12_RS07515	COG2951	lytic endotransglycosylase activity
FSC12_RS07520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FSC12_RS07525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FSC12_RS07565	COG2814	Major facilitator Superfamily
FSC12_RS07580	COG0693	protein deglycase activity
FSC12_RS07590	COG1012	belongs to the aldehyde dehydrogenase family
FSC12_RS07595	COG0733	neurotransmitter:sodium symporter activity
FSC12_RS07605	COG0428	transporter
FSC12_RS07635	COG0129	dihydroxy-acid dehydratase activity
FSC12_RS07655	COG0583	DNA-binding transcription factor activity
FSC12_RS07660	COG2233	PERMEase
FSC12_RS07675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FSC12_RS07700	COG0783	Belongs to the Dps family
FSC12_RS07715	COG2814	Major facilitator Superfamily
FSC12_RS07720	COG0656	L-ascorbic acid biosynthetic process
FSC12_RS07725	COG0583	DNA-binding transcription factor activity
FSC12_RS07730	COG1064	alcohol dehydrogenase
FSC12_RS07735	COG2818	Glycosylase
FSC12_RS07750	COG1194	a g-specific adenine glycosylase
FSC12_RS07765	COG0545	Peptidyl-prolyl cis-trans isomerase
FSC12_RS07780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FSC12_RS07805	COG0438	transferase activity, transferring glycosyl groups
FSC12_RS07810	COG0438	transferase activity, transferring glycosyl groups
FSC12_RS07815	COG0438	transferase activity, transferring glycosyl groups
FSC12_RS07820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FSC12_RS07830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FSC12_RS07845	COG1216	Glycosyl transferase, family 2
FSC12_RS07850	COG0438	transferase activity, transferring glycosyl groups
FSC12_RS07860	COG0438	transferase activity, transferring glycosyl groups
FSC12_RS07870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FSC12_RS07875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FSC12_RS07890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FSC12_RS07895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FSC12_RS07900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FSC12_RS07910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FSC12_RS07915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FSC12_RS07920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FSC12_RS07960	COG2963	transposase activity
FSC12_RS08025	COG2801	Transposase and inactivated derivatives
FSC12_RS08030	COG3077	Addiction module antitoxin, RelB DinJ family
FSC12_RS08065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FSC12_RS08075	COG1570	exodeoxyribonuclease VII activity
FSC12_RS08145	COG3586	endonuclease activity
FSC12_RS08165	COG3756	Protein conserved in bacteria
FSC12_RS08200	COG0271	Belongs to the BolA IbaG family
FSC12_RS08225	COG0586	Pfam SNARE associated Golgi protein
FSC12_RS08230	COG2259	Doxx family
FSC12_RS08240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FSC12_RS08240	COG0519	Catalyzes the synthesis of GMP from XMP
FSC12_RS08245	COG3706	GGDEF domain
FSC12_RS08250	COG3706	GGDEF domain
FSC12_RS08295	COG0534	Mate efflux family protein
FSC12_RS08300	COG0436	Aminotransferase
FSC12_RS08305	COG3501	Rhs element vgr protein
FSC12_RS08320	COG2837	iron assimilation
FSC12_RS08330	COG3123	guanosine phosphorylase activity
FSC12_RS08340	COG1683	Conserved Protein
FSC12_RS08345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FSC12_RS08350	COG1121	(ABC) transporter
FSC12_RS08400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FSC12_RS08410	COG1012	belongs to the aldehyde dehydrogenase family
FSC12_RS08430	COG0697	spore germination
FSC12_RS08440	COG0758	DNA mediated transformation
FSC12_RS08490	COG2814	Major facilitator Superfamily
FSC12_RS08510	COG0477	Major facilitator Superfamily
FSC12_RS08515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FSC12_RS08555	COG1253	flavin adenine dinucleotide binding
FSC12_RS08565	COG2860	membrane
FSC12_RS08570	COG0477	Major facilitator Superfamily
FSC12_RS08580	COG0318	PFAM AMP-dependent synthetase and ligase
FSC12_RS08600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FSC12_RS08625	COG0606	chelatase, subunit chli
FSC12_RS08635	COG0347	Belongs to the P(II) protein family
FSC12_RS08640	COG0004	ammonium transporteR
FSC12_RS08650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FSC12_RS08650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FSC12_RS08665	COG0586	Pfam SNARE associated Golgi protein
FSC12_RS08685	COG0795	lipopolysaccharide-transporting ATPase activity
FSC12_RS08690	COG0795	lipopolysaccharide-transporting ATPase activity
FSC12_RS08695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FSC12_RS08700	COG0793	Belongs to the peptidase S41A family
FSC12_RS08710	COG5002	protein histidine kinase activity
FSC12_RS08715	COG2197	response regulator
FSC12_RS08725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FSC12_RS08735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FSC12_RS08740	COG4974	Belongs to the 'phage' integrase family
FSC12_RS08765	COG0772	Belongs to the SEDS family
FSC12_RS08775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FSC12_RS08780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FSC12_RS08785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FSC12_RS08790	COG0494	nUDIX hydrolase
FSC12_RS08795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FSC12_RS08805	COG1538	Outer membrane efflux protein
FSC12_RS08820	COG1132	(ABC) transporter
FSC12_RS08830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FSC12_RS08840	COG0497	DNA recombination
FSC12_RS08845	COG3123	guanosine phosphorylase activity
FSC12_RS08850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FSC12_RS08860	COG0237	dephospho-CoA kinase activity
FSC12_RS08915	COG0779	Required for maturation of 30S ribosomal subunits
FSC12_RS08920	COG0195	Participates in both transcription termination and antitermination
FSC12_RS08925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FSC12_RS08930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FSC12_RS08940	COG2212	antiporter activity
FSC12_RS08945	COG1863	multisubunit Na H antiporter MnhE subunit
FSC12_RS08950	COG0651	ATP synthesis coupled electron transport
FSC12_RS08955	COG1006	Multisubunit Na H antiporter MnhC subunit
FSC12_RS08960	COG2111	Na H antiporter
FSC12_RS08960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FSC12_RS08975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FSC12_RS08980	COG4221	oxidoreductase activity
FSC12_RS08990	COG0488	(ABC) transporter
FSC12_RS09030	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FSC12_RS09050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FSC12_RS09055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FSC12_RS09065	COG2226	methyltransferase
FSC12_RS09115	COG0069	glutamate synthase activity
FSC12_RS09115	COG0067	glutamate synthase
FSC12_RS09115	COG0070	glutamate synthase
FSC12_RS09120	COG0493	'glutamate synthase
FSC12_RS09125	COG1704	LemA family
FSC12_RS09140	COG4969	Belongs to the N-Me-Phe pilin family
FSC12_RS09150	COG3307	-O-antigen
FSC12_RS09170	COG0675	Transposase, IS605 OrfB family
FSC12_RS09175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FSC12_RS09180	COG1758	RNA polymerase activity
FSC12_RS09185	COG0194	GDP metabolic process
FSC12_RS09195	COG4969	Belongs to the N-Me-Phe pilin family
FSC12_RS09230	COG0228	four-way junction DNA binding
FSC12_RS09235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FSC12_RS09245	COG0335	large ribosomal subunit rRNA binding
FSC12_RS09255	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FSC12_RS09260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FSC12_RS09265	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FSC12_RS09270	COG5380	lipid catabolic process
FSC12_RS09275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FSC12_RS09300	COG5006	permease, DMT superfamily
FSC12_RS09305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FSC12_RS09310	COG0277	FAD linked oxidase domain protein
FSC12_RS09325	COG2814	Major facilitator Superfamily
FSC12_RS09335	COG0628	permease
FSC12_RS09355	COG2226	methyltransferase
FSC12_RS09370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FSC12_RS09375	COG0254	rRNA binding
FSC12_RS09380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FSC12_RS09395	COG0534	Mate efflux family protein
FSC12_RS09405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FSC12_RS09425	COG1278	Cold shock
FSC12_RS09430	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS09445	COG0408	coproporphyrinogen oxidase activity
FSC12_RS09450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FSC12_RS09475	COG1127	ABC transporter
FSC12_RS09480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FSC12_RS09485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FSC12_RS09490	COG2854	intermembrane phospholipid transfer
FSC12_RS09500	COG0598	Magnesium transport protein CorA
FSC12_RS09510	COG0494	nUDIX hydrolase
FSC12_RS09515	COG1040	competence protein
FSC12_RS09520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FSC12_RS09530	COG2937	Belongs to the GPAT DAPAT family
FSC12_RS09535	COG1946	Acyl-CoA thioesterase
FSC12_RS09540	COG1301	dicarboxylic acid transport
FSC12_RS09560	COG1959	2 iron, 2 sulfur cluster binding
FSC12_RS09570	COG0433	COG0433 Predicted ATPase
FSC12_RS09575	COG0626	cystathionine gamma-synthase activity
FSC12_RS09595	COG0088	Forms part of the polypeptide exit tunnel
FSC12_RS09600	COG0089	rRNA binding
FSC12_RS09610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FSC12_RS09660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FSC12_RS09665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FSC12_RS09675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FSC12_RS09700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FSC12_RS09710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FSC12_RS09715	COG0202	RNA polymerase activity
FSC12_RS09720	COG0203	ribosomal protein L17
FSC12_RS09725	COG2072	flavoprotein involved in K transport
FSC12_RS09735	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS09740	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FSC12_RS09775	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FSC12_RS09780	COG0339	signal peptide processing
FSC12_RS09800	COG0557	exoribonuclease II activity
FSC12_RS09835	COG0179	Fumarylacetoacetate (FAA) hydrolase
FSC12_RS09840	COG2169	Transcriptional regulator
FSC12_RS09850	COG1295	ribonuclease BN
FSC12_RS09915	COG1702	phosphate starvation-inducible protein PhoH
FSC12_RS09920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FSC12_RS09925	COG0739	heme binding
FSC12_RS09925	COG0741	lytic transglycosylase activity
FSC12_RS09925	COG1196	nuclear chromosome segregation
FSC12_RS09965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FSC12_RS09970	COG1183	phosphatidylcholine synthase activity
FSC12_RS10005	COG1283	sodium-dependent phosphate transmembrane transporter activity
FSC12_RS10035	COG1607	acyl-coa hydrolase
FSC12_RS10065	COG2350	Protein conserved in bacteria
FSC12_RS10085	COG3781	membrane
FSC12_RS10090	COG2003	Belongs to the UPF0758 family
FSC12_RS10095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FSC12_RS10105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FSC12_RS10115	COG2814	Major facilitator Superfamily
FSC12_RS10135	COG0004	ammonium transporteR
FSC12_RS10150	COG3622	Belongs to the hyi family
FSC12_RS10155	COG2084	Dehydrogenase
FSC12_RS10160	COG1024	Enoyl-CoA hydratase
FSC12_RS10165	COG2205	protein histidine kinase activity
FSC12_RS10165	COG0784	Response regulator, receiver
FSC12_RS10165	COG5002	protein histidine kinase activity
FSC12_RS10170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FSC12_RS10185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FSC12_RS10195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FSC12_RS10205	COG1862	Preprotein translocase
FSC12_RS10220	COG1704	LemA family
FSC12_RS10230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FSC12_RS10260	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS10265	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS10275	COG2205	protein histidine kinase activity
FSC12_RS10280	COG0745	RESPONSE REGULATOR receiver
FSC12_RS10285	COG1113	amino acid transport
FSC12_RS10310	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FSC12_RS10325	COG2096	Adenosyltransferase
FSC12_RS10330	COG4206	TonB-dependent receptor
FSC12_RS10365	COG0159	tryptophan synthase activity
FSC12_RS10375	COG0285	dihydrofolate synthase activity
FSC12_RS10390	COG0450	alkyl hydroperoxide reductase
FSC12_RS10405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FSC12_RS10410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FSC12_RS10480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FSC12_RS10485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FSC12_RS10530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FSC12_RS10535	COG1408	metallophosphoesterase
FSC12_RS10545	COG0477	Major facilitator Superfamily
FSC12_RS10550	COG1272	protein, Hemolysin III
FSC12_RS10560	COG2153	protein acetylation
FSC12_RS10575	COG1250	3-hydroxyacyl-CoA dehydrogenase
FSC12_RS10575	COG1024	Enoyl-CoA hydratase
FSC12_RS10580	COG0183	Belongs to the thiolase family
FSC12_RS10585	COG2207	Transcriptional regulator
FSC12_RS10595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FSC12_RS10610	COG0183	Belongs to the thiolase family
FSC12_RS10635	COG0833	amino acid
FSC12_RS10645	COG2233	PERMEase
FSC12_RS10660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FSC12_RS10675	COG1902	pentaerythritol trinitrate reductase activity
FSC12_RS10695	COG0354	folic acid binding
FSC12_RS10700	COG2132	Multicopper oxidase
FSC12_RS10750	COG0564	pseudouridine synthase activity
FSC12_RS10765	COG2824	Alkylphosphonate utilization operon protein PhnA
FSC12_RS10780	COG0351	phosphomethylpyrimidine kinase
FSC12_RS10780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FSC12_RS10780	COG0352	thiamine-phosphate diphosphorylase activity
FSC12_RS10810	COG4772	TonB-dependent receptor
FSC12_RS10815	COG0431	NADPH-dependent FMN reductase
FSC12_RS10820	COG0798	PFAM Bile acid sodium symporter
FSC12_RS10825	COG0640	Transcriptional regulator
FSC12_RS10845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FSC12_RS10850	COG1335	isochorismatase
FSC12_RS10860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FSC12_RS10865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FSC12_RS10865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FSC12_RS10870	COG0745	RESPONSE REGULATOR receiver
FSC12_RS10875	COG2205	protein histidine kinase activity
FSC12_RS10885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FSC12_RS10905	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FSC12_RS10920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FSC12_RS10930	COG0713	ATP synthesis coupled electron transport
FSC12_RS10935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FSC12_RS10970	COG0583	DNA-binding transcription factor activity
FSC12_RS10985	COG0531	amino acid
FSC12_RS10990	COG4303	Ethanolamine ammonia lyase large subunit
FSC12_RS10995	COG4302	ethanolamine ammonia-lyase activity
FSC12_RS11005	COG0668	transmembrane transport
FSC12_RS11010	COG2081	HI0933 family
FSC12_RS11020	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FSC12_RS11035	COG0004	ammonium transporteR
FSC12_RS11055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FSC12_RS11055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FSC12_RS11070	COG0489	protein tyrosine kinase activity
FSC12_RS11115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FSC12_RS11140	COG0840	transmembrane signaling receptor activity
FSC12_RS11230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FSC12_RS11240	COG1289	transmembrane transporter activity
FSC12_RS11245	COG2814	Major facilitator Superfamily
FSC12_RS11255	COG0786	glutamate:sodium symporter activity
FSC12_RS11260	COG1115	amino acid carrier protein
FSC12_RS11270	COG1752	Esterase of the alpha-beta hydrolase superfamily
FSC12_RS11280	COG1607	acyl-coa hydrolase
FSC12_RS11290	COG2814	Major facilitator Superfamily
FSC12_RS11295	COG0583	DNA-binding transcription factor activity
FSC12_RS11315	COG0523	cobalamin synthesis protein
FSC12_RS11325	COG1285	pathogenesis
FSC12_RS11335	COG2203	Gaf domain
FSC12_RS11335	COG3706	GGDEF domain
FSC12_RS11335	COG4251	negative regulation of phosphorylation
FSC12_RS11335	COG5001	Diguanylate cyclase
FSC12_RS11370	COG0393	Putative heavy-metal-binding
FSC12_RS11375	COG0393	Putative heavy-metal-binding
FSC12_RS11380	COG1538	Outer membrane efflux protein
FSC12_RS11390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FSC12_RS11405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FSC12_RS11415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FSC12_RS11430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FSC12_RS11435	COG1648	precorrin-2 dehydrogenase activity
FSC12_RS11435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FSC12_RS11440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FSC12_RS11450	COG0531	amino acid
FSC12_RS11465	COG0321	lipoyl(octanoyl) transferase activity
FSC12_RS11470	COG2921	Belongs to the UPF0250 family
FSC12_RS11475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FSC12_RS11500	COG0586	Pfam SNARE associated Golgi protein
FSC12_RS11525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FSC12_RS11555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FSC12_RS11585	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FSC12_RS11595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FSC12_RS11600	COG0358	DNA primase activity
FSC12_RS11610	COG0564	pseudouridine synthase activity
FSC12_RS11625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FSC12_RS11635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FSC12_RS11665	COG0251	oxidation-reduction process
FSC12_RS11670	COG1309	transcriptional regulator
FSC12_RS11680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FSC12_RS11685	COG0505	Belongs to the CarA family
FSC12_RS11710	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FSC12_RS11715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FSC12_RS11725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FSC12_RS11760	COG1253	flavin adenine dinucleotide binding
FSC12_RS11780	COG2239	Acts as a magnesium transporter
FSC12_RS11790	COG0501	Belongs to the peptidase M48B family
FSC12_RS11795	COG0741	lytic transglycosylase activity
FSC12_RS11795	COG0739	heme binding
FSC12_RS11795	COG1196	nuclear chromosome segregation
FSC12_RS11800	COG0037	tRNA processing
FSC12_RS11810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FSC12_RS11815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FSC12_RS11830	COG0583	DNA-binding transcription factor activity
FSC12_RS11835	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS11840	COG2814	Major facilitator Superfamily
FSC12_RS11845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FSC12_RS11855	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FSC12_RS11880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FSC12_RS11885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FSC12_RS11890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FSC12_RS11895	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FSC12_RS11930	COG1115	amino acid carrier protein
FSC12_RS11935	COG1113	amino acid transport
FSC12_RS11945	COG0019	diaminopimelate decarboxylase activity
FSC12_RS11955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FSC12_RS11970	COG1280	lysine exporter protein (LysE YggA)
FSC12_RS12010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FSC12_RS12035	COG1671	Belongs to the UPF0178 family
FSC12_RS12050	COG4591	ABC-type transport system involved in lipoprotein release permease component
FSC12_RS12055	COG1136	(ABC) transporter
FSC12_RS12060	COG2333	competence protein COMEC
FSC12_RS12060	COG0658	competence protein
FSC12_RS12080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FSC12_RS12085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FSC12_RS12090	COG0628	permease
FSC12_RS12095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FSC12_RS12125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FSC12_RS12145	COG0823	Involved in the tonB-independent uptake of proteins
FSC12_RS12165	COG0824	Thioesterase
FSC12_RS12175	COG1473	amidohydrolase
FSC12_RS12190	COG2255	four-way junction helicase activity
FSC12_RS12205	COG0047	phosphoribosylformylglycinamidine synthase activity
FSC12_RS12205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FSC12_RS12220	COG0583	DNA-binding transcription factor activity
FSC12_RS12230	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
FSC12_RS12235	COG0778	Nitroreductase
FSC12_RS12240	COG1024	Enoyl-CoA hydratase
FSC12_RS12245	COG1056	cytidyltransferase-related domain
FSC12_RS12245	COG1051	belongs to the nudix hydrolase family
FSC12_RS12250	COG2353	YceI-like domain
FSC12_RS12255	COG0583	DNA-binding transcription factor activity
FSC12_RS12260	COG1279	arginine transmembrane transporter activity
FSC12_RS12270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FSC12_RS12280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FSC12_RS12285	COG0602	queuosine metabolic process
FSC12_RS12300	COG0583	DNA-binding transcription factor activity
FSC12_RS12305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FSC12_RS12310	COG4208	sulfate ABC transporter
FSC12_RS12325	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FSC12_RS12330	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FSC12_RS12340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FSC12_RS12360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FSC12_RS12385	COG0571	ribonuclease III activity
FSC12_RS12390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FSC12_RS12400	COG1381	Involved in DNA repair and RecF pathway recombination
FSC12_RS12405	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FSC12_RS12435	COG0436	Aminotransferase
FSC12_RS12440	COG0024	Methionine aminopeptidase
FSC12_RS12445	COG0052	Belongs to the universal ribosomal protein uS2 family
FSC12_RS12470	COG2951	lytic endotransglycosylase activity
FSC12_RS12485	COG0842	Transport permease protein
FSC12_RS12490	COG1131	(ABC) transporter
FSC12_RS12505	COG2814	Major facilitator Superfamily
FSC12_RS12560	COG1414	Transcriptional regulator
FSC12_RS12565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FSC12_RS12570	COG1414	Transcriptional regulator
FSC12_RS12575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FSC12_RS12580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FSC12_RS12585	COG0183	Belongs to the thiolase family
FSC12_RS12590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FSC12_RS12595	COG0596	Alpha beta hydrolase
FSC12_RS12600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FSC12_RS12605	COG3485	protocatechuate 3,4-dioxygenase
FSC12_RS12610	COG3485	protocatechuate 3,4-dioxygenase
FSC12_RS12640	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS12650	COG1012	belongs to the aldehyde dehydrogenase family
FSC12_RS12655	COG1024	Enoyl-CoA hydratase
FSC12_RS12660	COG2814	Major facilitator Superfamily
FSC12_RS12675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FSC12_RS12700	COG1278	Cold shock
FSC12_RS12715	COG1380	Effector of murein hydrolase LrgA
FSC12_RS12720	COG0583	DNA-binding transcription factor activity
FSC12_RS12770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FSC12_RS12790	COG3634	alkyl hydroperoxide reductase activity
FSC12_RS12795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FSC12_RS12805	COG0789	Transcriptional regulator
FSC12_RS12820	COG1720	tRNA m6t6A37 methyltransferase activity
FSC12_RS12830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FSC12_RS12840	COG0745	RESPONSE REGULATOR receiver
FSC12_RS12845	COG0642	Histidine kinase
FSC12_RS12855	COG0494	nUDIX hydrolase
FSC12_RS12865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FSC12_RS12870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FSC12_RS12875	COG3139	Protein of unknown function (DUF1315)
FSC12_RS12885	COG1301	dicarboxylic acid transport
FSC12_RS12895	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS12900	COG0693	protein deglycase activity
FSC12_RS12910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FSC12_RS12915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FSC12_RS12950	COG2252	PERMEase
FSC12_RS12955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FSC12_RS12970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FSC12_RS12980	COG0527	aspartate kinase activity
FSC12_RS12985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FSC12_RS12990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FSC12_RS13015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FSC12_RS13030	COG1047	Peptidyl-prolyl cis-trans
FSC12_RS13035	COG1252	NADH dehydrogenase
FSC12_RS13055	COG2351	hydroxyisourate hydrolase activity
FSC12_RS13075	COG2755	lipolytic protein G-D-S-L family
FSC12_RS13075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FSC12_RS13080	COG0436	Aminotransferase
FSC12_RS13085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FSC12_RS13090	COG0386	Belongs to the glutathione peroxidase family
FSC12_RS13105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FSC12_RS13125	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FSC12_RS13145	COG0012	GTP binding
FSC12_RS13150	COG2011	ABC-type metal ion transport system permease component
FSC12_RS13155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FSC12_RS13160	COG1464	Belongs to the NlpA lipoprotein family
FSC12_RS13295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FSC12_RS13305	COG4638	Rieske (2fe-2S)
FSC12_RS13320	COG2814	Major facilitator Superfamily
FSC12_RS13340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FSC12_RS13345	COG2814	Major facilitator Superfamily
FSC12_RS13365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FSC12_RS13370	COG0183	Belongs to the thiolase family
FSC12_RS13375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FSC12_RS13380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FSC12_RS13390	COG4829	muconolactone delta-isomerase
FSC12_RS13395	COG4948	Mandelate Racemase Muconate Lactonizing
FSC12_RS13400	COG0583	DNA-binding transcription factor activity
FSC12_RS13455	COG1454	alcohol dehydrogenase
FSC12_RS13490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FSC12_RS13490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FSC12_RS13495	COG1254	Belongs to the acylphosphatase family
FSC12_RS13525	COG3634	alkyl hydroperoxide reductase activity
FSC12_RS13555	COG1643	Atp-dependent helicase
FSC12_RS13575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FSC12_RS13580	COG2707	UPF0756 membrane protein
FSC12_RS13600	COG0564	pseudouridine synthase activity
FSC12_RS13605	COG0802	atpase or kinase
FSC12_RS13610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FSC12_RS13620	COG1923	regulation of RNA biosynthetic process
FSC12_RS13625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FSC12_RS13635	COG3178	'Phosphotransferase
FSC12_RS13640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FSC12_RS13650	COG1192	Involved in chromosome partitioning
FSC12_RS13655	COG1475	DNA binding
FSC12_RS13660	COG0811	peptide transport
FSC12_RS13670	COG1132	(ABC) transporter
FSC12_RS13675	COG1663	tetraacyldisaccharide 4'-kinase activity
FSC12_RS13695	COG0084	hydrolase, TatD family'
FSC12_RS13730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FSC12_RS13760	COG0776	regulation of translation
FSC12_RS13770	COG0284	orotidine-5'-phosphate decarboxylase activity
FSC12_RS13780	COG2431	L-lysine efflux transmembrane transporter activity
FSC12_RS13795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FSC12_RS13820	COG1253	flavin adenine dinucleotide binding
FSC12_RS13850	COG0308	aminopeptidase N
FSC12_RS13860	COG0589	response to stress
FSC12_RS13865	COG0589	response to stress
FSC12_RS13875	COG3135	benzoate transporter
FSC12_RS13885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FSC12_RS13900	COG0183	Belongs to the thiolase family
FSC12_RS13925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FSC12_RS13930	COG0824	Thioesterase
FSC12_RS13935	COG1454	alcohol dehydrogenase
FSC12_RS13940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FSC12_RS13960	COG0069	glutamate synthase activity
FSC12_RS13970	COG2308	Evidence 4 Homologs of previously reported genes of
FSC12_RS13980	COG1305	Transglutaminase-like
FSC12_RS13995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FSC12_RS14020	COG0360	Binds together with S18 to 16S ribosomal RNA
FSC12_RS14030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FSC12_RS14035	COG1845	cytochrome c oxidase, subunit III
FSC12_RS14040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FSC12_RS14045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FSC12_RS14070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FSC12_RS14090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FSC12_RS14095	COG2890	protein-(glutamine-N5) methyltransferase activity
FSC12_RS14100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FSC12_RS14105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FSC12_RS14135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FSC12_RS14160	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FSC12_RS14165	COG0477	Major facilitator Superfamily
FSC12_RS14170	COG0729	surface antigen
FSC12_RS14185	COG1570	exodeoxyribonuclease VII activity
FSC12_RS14215	COG0786	glutamate:sodium symporter activity
FSC12_RS14220	COG5001	Diguanylate cyclase
FSC12_RS14220	COG3300	MHYT domain
FSC12_RS14250	COG0024	Methionine aminopeptidase
FSC12_RS14255	COG0583	DNA-binding transcription factor activity
FSC12_RS14260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FSC12_RS14275	COG0446	pyridine nucleotide-disulphide oxidoreductase
FSC12_RS14275	COG1902	pentaerythritol trinitrate reductase activity
FSC12_RS14305	COG0148	phosphopyruvate hydratase activity
FSC12_RS14310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FSC12_RS14320	COG0772	Belongs to the SEDS family
FSC12_RS14340	COG4890	Cyd operon protein YbgT
FSC12_RS14345	COG1294	oxidase, subunit
FSC12_RS14395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FSC12_RS14415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FSC12_RS14425	COG0133	tryptophan synthase activity
FSC12_RS14430	COG0517	IMP dehydrogenase activity
FSC12_RS14460	COG0612	Peptidase, M16
FSC12_RS14465	COG0552	protein localization to endoplasmic reticulum
FSC12_RS14530	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS14535	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS14590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FSC12_RS14595	COG0730	response to heat
FSC12_RS14600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FSC12_RS14605	COG2207	Transcriptional regulator
FSC12_RS14610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FSC12_RS14615	COG1960	acyl-CoA dehydrogenase activity
FSC12_RS14620	COG2169	Transcriptional regulator
FSC12_RS14640	COG1525	nuclease
FSC12_RS14705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FSC12_RS14710	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FSC12_RS14720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FSC12_RS14735	COG2814	Major facilitator Superfamily
FSC12_RS14740	COG0509	glycine decarboxylation via glycine cleavage system
FSC12_RS14750	COG2030	dehydratase
FSC12_RS14755	COG1132	(ABC) transporter
FSC12_RS14760	COG0668	transmembrane transport
FSC12_RS14775	COG3122	Protein conserved in bacteria
FSC12_RS14780	COG3619	membrane
FSC12_RS14795	COG0640	Transcriptional regulator
FSC12_RS14800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FSC12_RS14810	COG0789	Transcriptional regulator
FSC12_RS14835	COG0830	nickel cation binding
FSC12_RS14845	COG0829	nickel cation binding
FSC12_RS14855	COG0831	urea catabolic process
FSC12_RS14865	COG0804	urea catabolic process
FSC12_RS14910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FSC12_RS14915	COG0183	Belongs to the thiolase family
FSC12_RS14920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FSC12_RS14925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FSC12_RS14930	COG3135	benzoate transporter
FSC12_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
FSC12_RS14940	COG0633	Ferredoxin
FSC12_RS14940	COG0543	2 iron, 2 sulfur cluster binding
FSC12_RS14945	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FSC12_RS14950	COG4638	Rieske (2fe-2S)
FSC12_RS14960	COG4829	muconolactone delta-isomerase
FSC12_RS14965	COG4948	Mandelate Racemase Muconate Lactonizing
FSC12_RS14970	COG0583	DNA-binding transcription factor activity
FSC12_RS14975	COG2814	Major facilitator Superfamily
FSC12_RS14985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FSC12_RS14990	COG0318	PFAM AMP-dependent synthetase and ligase
FSC12_RS15010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FSC12_RS15015	COG0583	DNA-binding transcription factor activity
FSC12_RS15030	COG0439	Biotin carboxylase
FSC12_RS15085	COG0673	inositol 2-dehydrogenase activity
FSC12_RS15105	COG2826	transposase and inactivated derivatives, IS30 family
FSC12_RS15125	COG1660	Displays ATPase and GTPase activities
FSC12_RS15260	COG2963	transposase activity
FSC12_RS15325	COG1802	Transcriptional regulator
FSC12_RS15325	COG4626	Terminase
FSC12_RS15400	COG1192	Involved in chromosome partitioning
FSC12_RS15500	COG0582	viral genome integration into host DNA
FSC12_RS15515	COG1230	cation diffusion facilitator family transporter
FSC12_RS15550	COG1683	Conserved Protein
FSC12_RS15600	COG4974	Belongs to the 'phage' integrase family
FSC12_RS15625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FSC12_RS15705	COG1373	ATPase (AAA superfamily
FSC12_RS15845	COG3173	Aminoglycoside phosphotransferase
FSC12_RS15855	COG0488	(ABC) transporter
FSC12_RS15915	COG0583	DNA-binding transcription factor activity
FSC12_RS15950	COG3657	addiction module killer protein
FSC12_RS15955	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FSC12_RS16015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain