locus-tag	class	description
C0119_RS00010	COG1525	nuclease
C0119_RS00030	COG2169	Transcriptional regulator
C0119_RS00035	COG1960	acyl-CoA dehydrogenase activity
C0119_RS00040	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0119_RS00045	COG2207	Transcriptional regulator
C0119_RS00050	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0119_RS00055	COG0730	response to heat
C0119_RS00060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0119_RS00115	COG1960	acyl-CoA dehydrogenase activity
C0119_RS00120	COG1960	acyl-CoA dehydrogenase activity
C0119_RS00200	COG0552	protein localization to endoplasmic reticulum
C0119_RS00205	COG0612	Peptidase, M16
C0119_RS00235	COG0517	IMP dehydrogenase activity
C0119_RS00240	COG0133	tryptophan synthase activity
C0119_RS00250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0119_RS00270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0119_RS00320	COG1294	oxidase, subunit
C0119_RS00325	COG4890	Cyd operon protein YbgT
C0119_RS00350	COG0772	Belongs to the SEDS family
C0119_RS00360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C0119_RS00365	COG0148	phosphopyruvate hydratase activity
C0119_RS00395	COG1902	pentaerythritol trinitrate reductase activity
C0119_RS00395	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0119_RS00410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0119_RS00415	COG0583	DNA-binding transcription factor activity
C0119_RS00420	COG0024	Methionine aminopeptidase
C0119_RS00445	COG0786	glutamate:sodium symporter activity
C0119_RS00460	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS00495	COG1570	exodeoxyribonuclease VII activity
C0119_RS00510	COG0729	surface antigen
C0119_RS00520	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C0119_RS00545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0119_RS00570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS00580	COG2890	protein-(glutamine-N5) methyltransferase activity
C0119_RS00585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0119_RS00600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0119_RS00625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0119_RS00630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0119_RS00635	COG1845	cytochrome c oxidase, subunit III
C0119_RS00640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C0119_RS00650	COG0360	Binds together with S18 to 16S ribosomal RNA
C0119_RS00670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0119_RS00685	COG1305	Transglutaminase-like
C0119_RS00695	COG2308	Evidence 4 Homologs of previously reported genes of
C0119_RS00705	COG0069	glutamate synthase activity
C0119_RS00725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0119_RS00730	COG1454	alcohol dehydrogenase
C0119_RS00735	COG0824	Thioesterase
C0119_RS00765	COG0183	Belongs to the thiolase family
C0119_RS00780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0119_RS00790	COG3135	benzoate transporter
C0119_RS00800	COG0589	response to stress
C0119_RS00805	COG0589	response to stress
C0119_RS00815	COG0308	aminopeptidase N
C0119_RS00845	COG1253	flavin adenine dinucleotide binding
C0119_RS00875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C0119_RS00890	COG2431	L-lysine efflux transmembrane transporter activity
C0119_RS00910	COG0776	regulation of translation
C0119_RS00940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0119_RS00975	COG0084	hydrolase, TatD family'
C0119_RS00995	COG1663	tetraacyldisaccharide 4'-kinase activity
C0119_RS01000	COG1132	(ABC) transporter
C0119_RS01010	COG0811	peptide transport
C0119_RS01015	COG1475	DNA binding
C0119_RS01020	COG1192	Involved in chromosome partitioning
C0119_RS01030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C0119_RS01035	COG3178	'Phosphotransferase
C0119_RS01045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0119_RS01050	COG1923	regulation of RNA biosynthetic process
C0119_RS01060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0119_RS01065	COG0802	atpase or kinase
C0119_RS01070	COG0564	pseudouridine synthase activity
C0119_RS01095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0119_RS01145	COG3634	alkyl hydroperoxide reductase activity
C0119_RS01175	COG1254	Belongs to the acylphosphatase family
C0119_RS01180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0119_RS01180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0119_RS01260	COG1464	Belongs to the NlpA lipoprotein family
C0119_RS01265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0119_RS01270	COG2011	ABC-type metal ion transport system permease component
C0119_RS01275	COG0012	GTP binding
C0119_RS01295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C0119_RS01310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C0119_RS01315	COG0436	Aminotransferase
C0119_RS01325	COG0386	Belongs to the glutathione peroxidase family
C0119_RS01330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS01335	COG0436	Aminotransferase
C0119_RS01340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C0119_RS01340	COG2755	lipolytic protein G-D-S-L family
C0119_RS01360	COG2351	hydroxyisourate hydrolase activity
C0119_RS01385	COG1252	NADH dehydrogenase
C0119_RS01390	COG1047	Peptidyl-prolyl cis-trans
C0119_RS01405	COG0501	Belongs to the peptidase M48B family
C0119_RS01410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0119_RS01450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0119_RS01455	COG0527	aspartate kinase activity
C0119_RS01465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0119_RS01480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0119_RS01485	COG2252	PERMEase
C0119_RS01505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0119_RS01510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0119_RS01520	COG0693	protein deglycase activity
C0119_RS01525	COG1960	acyl-CoA dehydrogenase activity
C0119_RS01530	COG1301	dicarboxylic acid transport
C0119_RS01540	COG3139	Protein of unknown function (DUF1315)
C0119_RS01545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0119_RS01550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0119_RS01560	COG0494	nUDIX hydrolase
C0119_RS01570	COG0642	Histidine kinase
C0119_RS01585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0119_RS01595	COG1720	tRNA m6t6A37 methyltransferase activity
C0119_RS01610	COG0789	Transcriptional regulator
C0119_RS01615	COG0826	peptidase U32
C0119_RS01620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0119_RS01645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0119_RS01710	COG1278	Cold shock
C0119_RS01740	COG3177	Filamentation induced by cAMP protein fic
C0119_RS01750	COG0737	Belongs to the 5'-nucleotidase family
C0119_RS01770	COG0431	NADPH-dependent FMN reductase
C0119_RS01775	COG0798	PFAM Bile acid sodium symporter
C0119_RS01785	COG0640	Transcriptional regulator
C0119_RS01895	COG0582	viral genome integration into host DNA
C0119_RS01905	COG1131	(ABC) transporter
C0119_RS01910	COG0842	Transport permease protein
C0119_RS01925	COG2951	lytic endotransglycosylase activity
C0119_RS01950	COG0052	Belongs to the universal ribosomal protein uS2 family
C0119_RS01955	COG0024	Methionine aminopeptidase
C0119_RS01960	COG0436	Aminotransferase
C0119_RS01990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C0119_RS01995	COG1381	Involved in DNA repair and RecF pathway recombination
C0119_RS02005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C0119_RS02010	COG0571	ribonuclease III activity
C0119_RS02035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0119_RS02055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0119_RS02065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0119_RS02070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0119_RS02085	COG4208	sulfate ABC transporter
C0119_RS02090	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C0119_RS02095	COG0583	DNA-binding transcription factor activity
C0119_RS02115	COG0602	queuosine metabolic process
C0119_RS02120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0119_RS02130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0119_RS02140	COG2353	YceI-like domain
C0119_RS02145	COG1056	cytidyltransferase-related domain
C0119_RS02145	COG1051	belongs to the nudix hydrolase family
C0119_RS02150	COG1024	Enoyl-CoA hydratase
C0119_RS02155	COG0778	Nitroreductase
C0119_RS02185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0119_RS02185	COG0047	phosphoribosylformylglycinamidine synthase activity
C0119_RS02200	COG2255	four-way junction helicase activity
C0119_RS02215	COG1473	amidohydrolase
C0119_RS02225	COG0824	Thioesterase
C0119_RS02245	COG0823	Involved in the tonB-independent uptake of proteins
C0119_RS02250	COG2885	chlorophyll binding
C0119_RS02265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0119_RS02305	COG0628	permease
C0119_RS02310	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0119_RS02315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0119_RS02335	COG0658	competence protein
C0119_RS02335	COG2333	competence protein COMEC
C0119_RS02340	COG1136	(ABC) transporter
C0119_RS02345	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0119_RS02360	COG1671	Belongs to the UPF0178 family
C0119_RS02385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS02425	COG1280	lysine exporter protein (LysE YggA)
C0119_RS02440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C0119_RS02460	COG1113	amino acid transport
C0119_RS02465	COG1115	amino acid carrier protein
C0119_RS02500	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C0119_RS02505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C0119_RS02510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C0119_RS02515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0119_RS02540	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C0119_RS02550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0119_RS02555	COG2814	Major facilitator Superfamily
C0119_RS02560	COG1960	acyl-CoA dehydrogenase activity
C0119_RS02565	COG0583	DNA-binding transcription factor activity
C0119_RS02580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0119_RS02590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C0119_RS02600	COG0037	tRNA processing
C0119_RS02605	COG0739	heme binding
C0119_RS02605	COG0741	lytic transglycosylase activity
C0119_RS02605	COG1196	nuclear chromosome segregation
C0119_RS02610	COG0501	Belongs to the peptidase M48B family
C0119_RS02620	COG2239	Acts as a magnesium transporter
C0119_RS02640	COG1253	flavin adenine dinucleotide binding
C0119_RS02645	COG2851	Citrate transporter
C0119_RS02675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0119_RS02685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0119_RS02690	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C0119_RS02715	COG0505	Belongs to the CarA family
C0119_RS02720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0119_RS02730	COG1309	transcriptional regulator
C0119_RS02735	COG0251	oxidation-reduction process
C0119_RS02770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0119_RS02795	COG0564	pseudouridine synthase activity
C0119_RS02805	COG0358	DNA primase activity
C0119_RS02810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0119_RS02820	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C0119_RS02850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0119_RS02880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0119_RS02905	COG0586	Pfam SNARE associated Golgi protein
C0119_RS02930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0119_RS02935	COG2921	Belongs to the UPF0250 family
C0119_RS02940	COG0321	lipoyl(octanoyl) transferase activity
C0119_RS02955	COG0531	amino acid
C0119_RS02965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0119_RS02970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0119_RS02970	COG1648	precorrin-2 dehydrogenase activity
C0119_RS02975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0119_RS02985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C0119_RS02995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0119_RS03010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS03020	COG1538	Outer membrane efflux protein
C0119_RS03025	COG0393	Putative heavy-metal-binding
C0119_RS03030	COG0393	Putative heavy-metal-binding
C0119_RS03035	COG0242	peptide deformylase activity
C0119_RS03065	COG5001	Diguanylate cyclase
C0119_RS03065	COG4251	negative regulation of phosphorylation
C0119_RS03065	COG3706	GGDEF domain
C0119_RS03065	COG2203	Gaf domain
C0119_RS03075	COG1285	pathogenesis
C0119_RS03105	COG0583	DNA-binding transcription factor activity
C0119_RS03110	COG2814	Major facilitator Superfamily
C0119_RS03120	COG1607	acyl-coa hydrolase
C0119_RS03130	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0119_RS03140	COG1115	amino acid carrier protein
C0119_RS03145	COG0786	glutamate:sodium symporter activity
C0119_RS03155	COG2814	Major facilitator Superfamily
C0119_RS03160	COG1289	transmembrane transporter activity
C0119_RS03170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C0119_RS03260	COG0840	transmembrane signaling receptor activity
C0119_RS03285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS03330	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS03350	COG0489	protein tyrosine kinase activity
C0119_RS03365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0119_RS03365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0119_RS03395	COG0004	ammonium transporteR
C0119_RS03410	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C0119_RS03420	COG2081	HI0933 family
C0119_RS03425	COG0668	transmembrane transport
C0119_RS03435	COG4302	ethanolamine ammonia-lyase activity
C0119_RS03445	COG0531	amino acid
C0119_RS03460	COG0583	DNA-binding transcription factor activity
C0119_RS03485	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0119_RS03490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0119_RS03495	COG0713	ATP synthesis coupled electron transport
C0119_RS03505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0119_RS03520	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C0119_RS03540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0119_RS03550	COG2205	protein histidine kinase activity
C0119_RS03555	COG0745	RESPONSE REGULATOR receiver
C0119_RS03560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0119_RS03560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0119_RS03570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0119_RS03580	COG0640	Transcriptional regulator
C0119_RS03585	COG0798	PFAM Bile acid sodium symporter
C0119_RS03590	COG0431	NADPH-dependent FMN reductase
C0119_RS03635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0119_RS03635	COG0352	thiamine-phosphate diphosphorylase activity
C0119_RS03635	COG0351	phosphomethylpyrimidine kinase
C0119_RS03650	COG2824	Alkylphosphonate utilization operon protein PhnA
C0119_RS03665	COG0564	pseudouridine synthase activity
C0119_RS03710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0119_RS03720	COG0354	folic acid binding
C0119_RS03755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0119_RS03765	COG1217	gtp-binding protein TYPA
C0119_RS03770	COG2233	PERMEase
C0119_RS03780	COG0833	amino acid
C0119_RS03800	COG0183	Belongs to the thiolase family
C0119_RS03815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS03820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0119_RS03825	COG2207	Transcriptional regulator
C0119_RS03830	COG0183	Belongs to the thiolase family
C0119_RS03835	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0119_RS03835	COG1024	Enoyl-CoA hydratase
C0119_RS03855	COG1272	protein, Hemolysin III
C0119_RS03860	COG0477	Major facilitator Superfamily
C0119_RS03870	COG1408	metallophosphoesterase
C0119_RS03875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0119_RS03900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0119_RS03905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0119_RS03980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0119_RS03985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0119_RS04000	COG0450	alkyl hydroperoxide reductase
C0119_RS04015	COG0285	dihydrofolate synthase activity
C0119_RS04025	COG0159	tryptophan synthase activity
C0119_RS04065	COG4206	TonB-dependent receptor
C0119_RS04070	COG2096	Adenosyltransferase
C0119_RS04085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0119_RS04110	COG1113	amino acid transport
C0119_RS04130	COG0745	RESPONSE REGULATOR receiver
C0119_RS04135	COG2205	protein histidine kinase activity
C0119_RS04145	COG1960	acyl-CoA dehydrogenase activity
C0119_RS04150	COG1960	acyl-CoA dehydrogenase activity
C0119_RS04180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C0119_RS04190	COG1704	LemA family
C0119_RS04205	COG1862	Preprotein translocase
C0119_RS04215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0119_RS04225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0119_RS04245	COG5002	protein histidine kinase activity
C0119_RS04245	COG2205	protein histidine kinase activity
C0119_RS04245	COG0784	Response regulator, receiver
C0119_RS04250	COG1024	Enoyl-CoA hydratase
C0119_RS04255	COG2084	Dehydrogenase
C0119_RS04260	COG3622	Belongs to the hyi family
C0119_RS04275	COG0004	ammonium transporteR
C0119_RS04300	COG2814	Major facilitator Superfamily
C0119_RS04345	COG1196	nuclear chromosome segregation
C0119_RS04345	COG0741	lytic transglycosylase activity
C0119_RS04345	COG0739	heme binding
C0119_RS04525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0119_RS04530	COG2003	Belongs to the UPF0758 family
C0119_RS04535	COG3781	membrane
C0119_RS04555	COG2350	Protein conserved in bacteria
C0119_RS04585	COG1607	acyl-coa hydrolase
C0119_RS04615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS04655	COG1183	phosphatidylcholine synthase activity
C0119_RS04660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C0119_RS04700	COG0739	heme binding
C0119_RS04700	COG1196	nuclear chromosome segregation
C0119_RS04700	COG0741	lytic transglycosylase activity
C0119_RS04705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0119_RS04710	COG1702	phosphate starvation-inducible protein PhoH
C0119_RS04755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS04780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS04785	COG0625	glutathione transferase activity
C0119_RS04820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C0119_RS04830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C0119_RS04850	COG2009	succinate dehydrogenase
C0119_RS04875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS04880	COG0183	Belongs to the thiolase family
C0119_RS04895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS04900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0119_RS04935	COG1295	ribonuclease BN
C0119_RS04955	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0119_RS04990	COG0557	exoribonuclease II activity
C0119_RS05000	COG0339	signal peptide processing
C0119_RS05005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C0119_RS05040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C0119_RS05045	COG1960	acyl-CoA dehydrogenase activity
C0119_RS05050	COG2072	flavoprotein involved in K transport
C0119_RS05055	COG0203	ribosomal protein L17
C0119_RS05060	COG0202	RNA polymerase activity
C0119_RS05065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0119_RS05075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0119_RS05100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0119_RS05110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0119_RS05115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0119_RS05165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0119_RS05175	COG0089	rRNA binding
C0119_RS05180	COG0088	Forms part of the polypeptide exit tunnel
C0119_RS05200	COG0626	cystathionine gamma-synthase activity
C0119_RS05205	COG0433	COG0433 Predicted ATPase
C0119_RS05215	COG1959	2 iron, 2 sulfur cluster binding
C0119_RS05235	COG1301	dicarboxylic acid transport
C0119_RS05240	COG1946	Acyl-CoA thioesterase
C0119_RS05245	COG2937	Belongs to the GPAT DAPAT family
C0119_RS05255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0119_RS05260	COG1040	competence protein
C0119_RS05265	COG0494	nUDIX hydrolase
C0119_RS05275	COG0598	Magnesium transport protein CorA
C0119_RS05285	COG2854	intermembrane phospholipid transfer
C0119_RS05290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0119_RS05295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0119_RS05300	COG1127	ABC transporter
C0119_RS05325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0119_RS05330	COG0408	coproporphyrinogen oxidase activity
C0119_RS05345	COG1960	acyl-CoA dehydrogenase activity
C0119_RS05350	COG1278	Cold shock
C0119_RS05360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0119_RS05370	COG0534	Mate efflux family protein
C0119_RS05385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0119_RS05390	COG0254	rRNA binding
C0119_RS05395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0119_RS05410	COG2226	methyltransferase
C0119_RS05430	COG0628	permease
C0119_RS05440	COG2814	Major facilitator Superfamily
C0119_RS05455	COG0277	FAD linked oxidase domain protein
C0119_RS05460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0119_RS05465	COG5006	permease, DMT superfamily
C0119_RS05490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0119_RS05495	COG5380	lipid catabolic process
C0119_RS05510	COG0335	large ribosomal subunit rRNA binding
C0119_RS05520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0119_RS05525	COG0228	four-way junction DNA binding
C0119_RS05570	COG0194	GDP metabolic process
C0119_RS05575	COG1758	RNA polymerase activity
C0119_RS05580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0119_RS05600	COG0675	Transposase, IS605 OrfB family
C0119_RS05615	COG0675	Transposase, IS605 OrfB family
C0119_RS05625	COG3307	-O-antigen
C0119_RS05635	COG4969	Belongs to the N-Me-Phe pilin family
C0119_RS05650	COG1704	LemA family
C0119_RS05655	COG0493	'glutamate synthase
C0119_RS05660	COG0069	glutamate synthase activity
C0119_RS05660	COG0070	glutamate synthase
C0119_RS05660	COG0067	glutamate synthase
C0119_RS05710	COG2226	methyltransferase
C0119_RS05715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0119_RS05720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0119_RS05725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0119_RS05745	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0119_RS05790	COG0488	(ABC) transporter
C0119_RS05800	COG4221	oxidoreductase activity
C0119_RS05805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0119_RS05820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0119_RS05820	COG2111	Na H antiporter
C0119_RS05825	COG1006	Multisubunit Na H antiporter MnhC subunit
C0119_RS05830	COG0651	ATP synthesis coupled electron transport
C0119_RS05835	COG1863	multisubunit Na H antiporter MnhE subunit
C0119_RS05840	COG2212	antiporter activity
C0119_RS05845	COG1320	monovalent cation:proton antiporter activity
C0119_RS05850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0119_RS05860	COG0195	Participates in both transcription termination and antitermination
C0119_RS05865	COG0779	Required for maturation of 30S ribosomal subunits
C0119_RS05895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0119_RS05920	COG0237	dephospho-CoA kinase activity
C0119_RS05930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0119_RS05935	COG3123	guanosine phosphorylase activity
C0119_RS05940	COG0497	DNA recombination
C0119_RS05950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0119_RS05960	COG1132	(ABC) transporter
C0119_RS05985	COG1538	Outer membrane efflux protein
C0119_RS05995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0119_RS06000	COG0494	nUDIX hydrolase
C0119_RS06005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C0119_RS06010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0119_RS06015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0119_RS06025	COG0772	Belongs to the SEDS family
C0119_RS06050	COG4974	Belongs to the 'phage' integrase family
C0119_RS06055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0119_RS06065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0119_RS06075	COG2197	response regulator
C0119_RS06080	COG5002	protein histidine kinase activity
C0119_RS06090	COG0793	Belongs to the peptidase S41A family
C0119_RS06095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C0119_RS06100	COG0795	lipopolysaccharide-transporting ATPase activity
C0119_RS06105	COG0795	lipopolysaccharide-transporting ATPase activity
C0119_RS06125	COG0586	Pfam SNARE associated Golgi protein
C0119_RS06140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0119_RS06140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0119_RS06150	COG0004	ammonium transporteR
C0119_RS06155	COG0347	Belongs to the P(II) protein family
C0119_RS06190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0119_RS06205	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS06215	COG0477	Major facilitator Superfamily
C0119_RS06220	COG2860	membrane
C0119_RS06230	COG1253	flavin adenine dinucleotide binding
C0119_RS06260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0119_RS06265	COG0477	Major facilitator Superfamily
C0119_RS06285	COG2814	Major facilitator Superfamily
C0119_RS06340	COG0758	DNA mediated transformation
C0119_RS06350	COG0697	spore germination
C0119_RS06355	COG0386	Belongs to the glutathione peroxidase family
C0119_RS06375	COG1012	belongs to the aldehyde dehydrogenase family
C0119_RS06405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0119_RS06455	COG1121	(ABC) transporter
C0119_RS06460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0119_RS06470	COG3123	guanosine phosphorylase activity
C0119_RS06480	COG2837	iron assimilation
C0119_RS06490	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS06505	COG0436	Aminotransferase
C0119_RS06510	COG0534	Mate efflux family protein
C0119_RS06560	COG3706	GGDEF domain
C0119_RS06570	COG1715	Restriction endonuclease
C0119_RS06575	COG0519	Catalyzes the synthesis of GMP from XMP
C0119_RS06575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0119_RS06580	COG0586	Pfam SNARE associated Golgi protein
C0119_RS06595	COG1192	Involved in chromosome partitioning
C0119_RS06640	COG3756	Protein conserved in bacteria
C0119_RS06770	COG3002	Belongs to the UPF0753 family
C0119_RS06775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0119_RS06785	COG3421	Type III restriction
C0119_RS06805	COG1484	DNA-dependent DNA replication
C0119_RS06830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0119_RS06835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0119_RS06845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C0119_RS06855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0119_RS06895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0119_RS06905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0119_RS06920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0119_RS06925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0119_RS06935	COG0297	glycogen (starch) synthase activity
C0119_RS06995	COG1088	dTDP-glucose 4,6-dehydratase activity
C0119_RS07005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0119_RS07015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0119_RS07020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0119_RS07025	COG0438	transferase activity, transferring glycosyl groups
C0119_RS07030	COG0438	transferase activity, transferring glycosyl groups
C0119_RS07035	COG0438	transferase activity, transferring glycosyl groups
C0119_RS07060	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C0119_RS07065	COG1596	polysaccharide export
C0119_RS07085	COG0545	Peptidyl-prolyl cis-trans isomerase
C0119_RS07100	COG1194	a g-specific adenine glycosylase
C0119_RS07115	COG2818	Glycosylase
C0119_RS07120	COG1064	alcohol dehydrogenase
C0119_RS07130	COG0675	Transposase, IS605 OrfB family
C0119_RS07145	COG0783	Belongs to the Dps family
C0119_RS07165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS07180	COG2233	PERMEase
C0119_RS07185	COG0583	DNA-binding transcription factor activity
C0119_RS07205	COG0129	dihydroxy-acid dehydratase activity
C0119_RS07230	COG0428	transporter
C0119_RS07240	COG0733	neurotransmitter:sodium symporter activity
C0119_RS07245	COG1012	belongs to the aldehyde dehydrogenase family
C0119_RS07255	COG0693	protein deglycase activity
C0119_RS07275	COG2814	Major facilitator Superfamily
C0119_RS07305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0119_RS07315	COG0657	acetylesterase activity
C0119_RS07375	COG1063	alcohol dehydrogenase
C0119_RS07390	COG0187	DNA topoisomerase II activity
C0119_RS07400	COG0592	DNA-directed DNA polymerase activity
C0119_RS07415	COG0594	ribonuclease P activity
C0119_RS07420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0119_RS07425	COG0706	membrane insertase activity
C0119_RS07465	COG0402	S-adenosylhomocysteine deaminase activity
C0119_RS07470	COG0861	Integral membrane protein TerC family
C0119_RS07475	COG2814	Major facilitator Superfamily
C0119_RS07480	COG2388	GCN5-related N-acetyl-transferase
C0119_RS07505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0119_RS07520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0119_RS07525	COG2951	lytic endotransglycosylase activity
C0119_RS07530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C0119_RS07535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0119_RS07570	COG2133	pyrroloquinoline quinone binding
C0119_RS07585	COG1047	Peptidyl-prolyl cis-trans
C0119_RS07595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0119_RS07600	COG0196	riboflavin kinase activity
C0119_RS07610	COG1309	transcriptional regulator
C0119_RS07615	COG1116	anion transmembrane transporter activity
C0119_RS07620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0119_RS07625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0119_RS07630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS07640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C0119_RS07640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0119_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS07665	COG0546	phosphoglycolate phosphatase activity
C0119_RS07670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0119_RS07690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0119_RS07695	COG1309	transcriptional regulator
C0119_RS07700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0119_RS07710	COG3023	N-Acetylmuramoyl-L-alanine amidase
C0119_RS07720	COG5487	UPF0391 membrane protein
C0119_RS07725	COG2983	Belongs to the UPF0260 family
C0119_RS07730	COG3300	MHYT domain
C0119_RS07730	COG5001	Diguanylate cyclase
C0119_RS07735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0119_RS07740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0119_RS07750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0119_RS07760	COG1335	isochorismatase
C0119_RS07765	COG0385	Bile acid
C0119_RS07775	COG3830	Belongs to the UPF0237 family
C0119_RS07775	COG0560	Phosphoserine phosphatase
C0119_RS07840	COG2733	membrane
C0119_RS07855	COG2918	glutathione biosynthetic process
C0119_RS07860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0119_RS07870	COG3150	esterase
C0119_RS07895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS07900	COG0410	ABC transporter
C0119_RS07925	COG0784	Response regulator, receiver
C0119_RS07925	COG2205	protein histidine kinase activity
C0119_RS07950	COG4266	Belongs to the allantoicase family
C0119_RS07955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0119_RS07970	COG2233	PERMEase
C0119_RS08025	COG1393	Belongs to the ArsC family
C0119_RS08030	COG0708	Exodeoxyribonuclease III
C0119_RS08040	COG1278	Cold shock
C0119_RS08055	COG2132	Multicopper oxidase
C0119_RS08070	COG0189	ligase activity
C0119_RS08095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0119_RS08140	COG2119	membrane
C0119_RS08145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS08145	COG0426	domain, Protein
C0119_RS08160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0119_RS08170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C0119_RS08190	COG0640	Transcriptional regulator
C0119_RS08195	COG1902	pentaerythritol trinitrate reductase activity
C0119_RS08200	COG1519	Transferase
C0119_RS08205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0119_RS08210	COG0668	transmembrane transport
C0119_RS08220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0119_RS08235	COG0307	riboflavin synthase, alpha
C0119_RS08245	COG0431	NADPH-dependent FMN reductase
C0119_RS08260	COG0784	Response regulator, receiver
C0119_RS08260	COG2205	protein histidine kinase activity
C0119_RS08265	COG3162	membrane
C0119_RS08275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0119_RS08290	COG3706	GGDEF domain
C0119_RS08295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0119_RS08300	COG0351	phosphomethylpyrimidine kinase
C0119_RS08300	COG0352	thiamine-phosphate diphosphorylase activity
C0119_RS08300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0119_RS08310	COG2814	Major facilitator Superfamily
C0119_RS08340	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C0119_RS08370	COG3158	transport of potassium into the cell
C0119_RS08405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0119_RS08460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0119_RS08465	COG0131	Imidazoleglycerol-phosphate dehydratase
C0119_RS08525	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0119_RS08525	COG1024	Enoyl-CoA hydratase
C0119_RS08530	COG3706	GGDEF domain
C0119_RS08555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0119_RS08575	COG3275	phosphorelay sensor kinase activity
C0119_RS08585	COG0181	hydroxymethylbilane synthase activity
C0119_RS08605	COG0824	Thioesterase
C0119_RS08635	COG0546	phosphoglycolate phosphatase activity
C0119_RS08665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0119_RS08685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0119_RS08690	COG0081	regulation of translation
C0119_RS08705	COG0085	RNA polymerase activity
C0119_RS08710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0119_RS08740	COG2056	Na+-H+ antiporter family
C0119_RS08755	COG0326	Molecular chaperone. Has ATPase activity
C0119_RS08785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0119_RS08795	COG0427	acetyl-CoA hydrolase
C0119_RS08825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0119_RS08865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C0119_RS08870	COG1074	ATP-dependent DNA helicase activity
C0119_RS08875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0119_RS08885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0119_RS08890	COG1185	polyribonucleotide nucleotidyltransferase activity
C0119_RS08895	COG2841	Protein conserved in bacteria
C0119_RS08900	COG0789	Transcriptional regulator
C0119_RS08915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0119_RS08925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0119_RS08945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0119_RS08950	COG4535	Mg2 and Co2 transporter CorC
C0119_RS08975	COG0644	oxidoreductase
C0119_RS08975	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C0119_RS08985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0119_RS09000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0119_RS09015	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C0119_RS09055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0119_RS09075	COG0751	glycine-tRNA ligase activity
C0119_RS09095	COG0471	metal ion transport
C0119_RS09105	COG1983	PspC domain protein
C0119_RS09130	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS09135	COG1530	ribonuclease E activity
C0119_RS09150	COG0546	phosphoglycolate phosphatase activity
C0119_RS09155	COG3971	2-oxopent-4-enoate hydratase activity
C0119_RS09160	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C0119_RS09195	COG0583	DNA-binding transcription factor activity
C0119_RS09200	COG4638	Rieske (2fe-2S)
C0119_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS09220	COG3384	dioxygenase
C0119_RS09225	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0119_RS09245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C0119_RS09250	COG1960	acyl-CoA dehydrogenase activity
C0119_RS09295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0119_RS09310	COG0473	3-isopropylmalate dehydrogenase activity
C0119_RS09340	COG0252	asparaginase activity
C0119_RS09370	COG1560	Kdo2-lipid A biosynthetic process
C0119_RS09375	COG0488	(ABC) transporter
C0119_RS09380	COG2900	Belongs to the SlyX family
C0119_RS09410	COG1929	Belongs to the glycerate kinase type-1 family
C0119_RS09415	COG0210	DNA helicase
C0119_RS09420	COG0724	RNA recognition motif
C0119_RS09440	COG4651	solute:proton antiporter activity
C0119_RS09440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0119_RS09465	COG0788	formyltetrahydrofolate deformylase activity
C0119_RS09500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C0119_RS09505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0119_RS09555	COG2813	Specifically methylates the guanine in position
C0119_RS09555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0119_RS09560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0119_RS09565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0119_RS09570	COG4774	siderophore transport
C0119_RS09580	COG3128	pkhd-type hydroxylase
C0119_RS09585	COG4774	siderophore transport
C0119_RS09590	COG4774	siderophore transport
C0119_RS09600	COG0740	serine-type endopeptidase activity
C0119_RS09615	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C0119_RS09615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C0119_RS09625	COG0280	phosphate acetyltransferase
C0119_RS09625	COG0857	belongs to the CobB CobQ family
C0119_RS09630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0119_RS09655	COG0793	Belongs to the peptidase S41A family
C0119_RS09670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C0119_RS09685	COG0084	hydrolase, TatD family'
C0119_RS09715	COG1162	GTPase activity
C0119_RS09720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0119_RS09730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C0119_RS09740	COG1538	Outer membrane efflux protein
C0119_RS09745	COG1136	(ABC) transporter
C0119_RS09745	COG0577	efflux transmembrane transporter activity
C0119_RS09750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS09775	COG0028	Belongs to the TPP enzyme family
C0119_RS09780	COG0440	acetolactate synthase activity
C0119_RS09790	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS09820	COG2975	iron-sulfur cluster assembly
C0119_RS09840	COG1426	Protein conserved in bacteria
C0119_RS09850	COG0124	histidyl-tRNA synthetase
C0119_RS09860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0119_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS09880	COG3956	TIGRFAM MazG family protein
C0119_RS09885	COG1555	photosystem II stabilization
C0119_RS09890	COG0617	tRNA 3'-terminal CCA addition
C0119_RS09895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0119_RS09910	COG1660	Displays ATPase and GTPase activities
C0119_RS09930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0119_RS10020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0119_RS10040	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS10065	COG0546	phosphoglycolate phosphatase activity
C0119_RS10075	COG0675	Transposase, IS605 OrfB family
C0119_RS10090	COG0625	glutathione transferase activity
C0119_RS10100	COG1238	metal cluster binding
C0119_RS10130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0119_RS10160	COG0248	Ppx GppA phosphatase
C0119_RS10170	COG0037	tRNA processing
C0119_RS10220	COG1764	response to oxidative stress
C0119_RS10225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS10280	COG2969	positive regulation of protein catabolic process
C0119_RS10285	COG0625	glutathione transferase activity
C0119_RS10290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0119_RS10295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0119_RS10300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C0119_RS10305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0119_RS10310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0119_RS10335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0119_RS10350	COG0494	nUDIX hydrolase
C0119_RS10360	COG1214	PFAM Peptidase M22, glycoprotease
C0119_RS10365	COG1968	undecaprenyl-diphosphatase activity
C0119_RS10385	COG4269	membrane
C0119_RS10400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0119_RS10410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0119_RS10420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0119_RS10435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0119_RS10440	COG3545	Serine hydrolase
C0119_RS10445	COG3545	Serine hydrolase
C0119_RS10455	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C0119_RS10455	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C0119_RS10460	COG0730	response to heat
C0119_RS10470	COG1196	nuclear chromosome segregation
C0119_RS10480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0119_RS10485	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C0119_RS10490	COG2193	ferroxidase activity
C0119_RS10505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0119_RS10510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0119_RS10530	COG0009	L-threonylcarbamoyladenylate synthase
C0119_RS10535	COG3101	peptidyl-lysine hydroxylation
C0119_RS10540	COG1399	metal-binding, possibly nucleic acid-binding protein
C0119_RS10555	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS10560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0119_RS10565	COG1652	LysM domain
C0119_RS10585	COG0251	oxidation-reduction process
C0119_RS10590	COG1113	amino acid transport
C0119_RS10595	COG1981	membrane
C0119_RS10610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0119_RS10625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0119_RS10635	COG0456	acetyltransferase
C0119_RS10645	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0119_RS10650	COG0492	ferredoxin-NADP+ reductase activity
C0119_RS10685	COG0204	Acyl-transferase
C0119_RS10690	COG2885	chlorophyll binding
C0119_RS10695	COG0210	DNA helicase
C0119_RS10700	COG0756	dUTP diphosphatase activity
C0119_RS10705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0119_RS10715	COG0121	glutamine amidotransferase
C0119_RS10730	COG2914	Belongs to the UPF0125 (RnfH) family
C0119_RS10735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0119_RS10740	COG0735	belongs to the Fur family
C0119_RS10770	COG0420	3'-5' exonuclease activity
C0119_RS10795	COG2050	protein possibly involved in aromatic compounds catabolism
C0119_RS10810	COG0582	viral genome integration into host DNA
C0119_RS10855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0119_RS10870	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS10915	COG5001	Diguanylate cyclase
C0119_RS10915	COG3300	MHYT domain
C0119_RS10940	COG3177	Filamentation induced by cAMP protein fic
C0119_RS10945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0119_RS10960	COG0625	glutathione transferase activity
C0119_RS10975	COG1448	Aminotransferase
C0119_RS10980	COG1113	amino acid transport
C0119_RS11000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0119_RS11005	COG0596	Alpha beta hydrolase
C0119_RS11020	COG4106	trans-aconitate 2-methyltransferase activity
C0119_RS11045	COG1294	oxidase, subunit
C0119_RS11060	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C0119_RS11090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0119_RS11100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0119_RS11105	COG1077	Cell shape determining protein MreB Mrl
C0119_RS11110	COG1792	Involved in formation and maintenance of cell shape
C0119_RS11115	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C0119_RS11125	COG1530	ribonuclease E activity
C0119_RS11130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0119_RS11160	COG1113	amino acid transport
C0119_RS11165	COG2828	Protein conserved in bacteria
C0119_RS11170	COG0142	geranyltranstransferase activity
C0119_RS11175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0119_RS11210	COG0546	phosphoglycolate phosphatase activity
C0119_RS11215	COG2323	membrane
C0119_RS11230	COG2852	Protein conserved in bacteria
C0119_RS11240	COG0525	valine-tRNA ligase activity
C0119_RS11250	COG0300	oxidoreductase activity
C0119_RS11255	COG2066	Belongs to the glutaminase family
C0119_RS11260	COG2376	Dihydroxyacetone kinase
C0119_RS11290	COG0306	phosphate transporter
C0119_RS11335	COG4181	ATPase activity
C0119_RS11340	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C0119_RS11350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0119_RS11360	COG0583	DNA-binding transcription factor activity
C0119_RS11370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS11375	COG1773	rubredoxin
C0119_RS11380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0119_RS11400	COG2354	Protein conserved in bacteria
C0119_RS11405	COG2321	neutral zinc metallopeptidase
C0119_RS11440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0119_RS11440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS11445	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS11465	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C0119_RS11470	COG1053	succinate dehydrogenase
C0119_RS11475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0119_RS11490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS11500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0119_RS11510	COG0726	polysaccharide deacetylase
C0119_RS11510	COG1649	PFAM Uncharacterised BCR, COG1649
C0119_RS11515	COG1215	transferase activity, transferring glycosyl groups
C0119_RS11525	COG0726	polysaccharide deacetylase
C0119_RS11525	COG1649	PFAM Uncharacterised BCR, COG1649
C0119_RS11530	COG2268	Band 7 protein
C0119_RS11595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0119_RS11670	COG0742	ribosomal rna small subunit methyltransferase
C0119_RS11675	COG0768	penicillin binding
C0119_RS11700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0119_RS11705	COG2878	Part of a membrane complex involved in electron transport
C0119_RS11710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0119_RS11720	COG3384	dioxygenase
C0119_RS11730	COG2234	aminopeptidase activity
C0119_RS11740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0119_RS11775	COG0006	proline dipeptidase activity
C0119_RS11780	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS11790	COG2155	Conserved Protein
C0119_RS11805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0119_RS11810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0119_RS11840	COG0657	acetylesterase activity
C0119_RS11860	COG1388	LysM domain
C0119_RS11860	COG0741	lytic transglycosylase activity
C0119_RS11865	COG4166	transmembrane transport
C0119_RS11870	COG4174	ABC transporter (Permease)
C0119_RS11875	COG4239	(ABC) transporter, permease
C0119_RS11880	COG4172	Belongs to the ABC transporter superfamily
C0119_RS11920	COG0833	amino acid
C0119_RS11930	COG4771	TonB-dependent receptor
C0119_RS11940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0119_RS11945	COG0418	dihydroorotase activity
C0119_RS11950	COG3706	GGDEF domain
C0119_RS11950	COG2203	Gaf domain
C0119_RS11950	COG5001	Diguanylate cyclase
C0119_RS11950	COG4251	negative regulation of phosphorylation
C0119_RS11960	COG1620	l-lactate permease
C0119_RS11965	COG2186	Transcriptional regulator
C0119_RS11975	COG0277	FAD linked oxidase domain protein
C0119_RS11985	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0119_RS11985	COG1902	pentaerythritol trinitrate reductase activity
C0119_RS11995	COG0642	Histidine kinase
C0119_RS12010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0119_RS12025	COG0640	Transcriptional regulator
C0119_RS12060	COG1741	Belongs to the pirin family
C0119_RS12075	COG3739	integral membrane protein
C0119_RS12090	COG3706	GGDEF domain
C0119_RS12105	COG0302	gtp cyclohydrolase
C0119_RS12120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0119_RS12125	COG0512	Glutamine amidotransferase of anthranilate synthase
C0119_RS12130	COG0174	glutamine synthetase
C0119_RS12145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0119_RS12185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0119_RS12195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0119_RS12215	COG1335	isochorismatase
C0119_RS12220	COG0251	oxidation-reduction process
C0119_RS12225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS12230	COG2233	PERMEase
C0119_RS12235	COG2084	Dehydrogenase
C0119_RS12245	COG1960	acyl-CoA dehydrogenase activity
C0119_RS12250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0119_RS12255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS12285	COG2199	diguanylate cyclase activity
C0119_RS12295	COG0556	nucleotide-excision repair
C0119_RS12325	COG1733	regulation of RNA biosynthetic process
C0119_RS12330	COG2814	Major facilitator Superfamily
C0119_RS12340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0119_RS12345	COG0671	phosphoesterase, PA-phosphatase related
C0119_RS12355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0119_RS12360	COG0076	glutamate decarboxylase activity
C0119_RS12370	COG0573	inorganic phosphate transmembrane transporter activity
C0119_RS12380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0119_RS12390	COG0616	signal peptide processing
C0119_RS12450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0119_RS12455	COG1686	Belongs to the peptidase S11 family
C0119_RS12480	COG0583	DNA-binding transcription factor activity
C0119_RS12485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0119_RS12490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0119_RS12495	COG1067	ATP-dependent peptidase activity
C0119_RS12535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0119_RS12540	COG1966	Carbon starvation protein
C0119_RS12545	COG2879	small protein
C0119_RS12550	COG0714	Associated with various cellular activities
C0119_RS12575	COG0281	malic enzyme
C0119_RS12595	COG1136	(ABC) transporter
C0119_RS12620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0119_RS12625	COG1765	OsmC-like protein
C0119_RS12635	COG0667	Aldo Keto reductase
C0119_RS12655	COG0540	Belongs to the ATCase OTCase family
C0119_RS12665	COG2885	chlorophyll binding
C0119_RS12665	COG3047	cAMP biosynthetic process
C0119_RS12690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0119_RS12695	COG0659	secondary active sulfate transmembrane transporter activity
C0119_RS12715	COG2363	Small membrane protein
C0119_RS12730	COG1278	Cold shock
C0119_RS12735	COG0513	Belongs to the DEAD box helicase family
C0119_RS12745	COG0778	Nitroreductase
C0119_RS12800	COG4783	chaperone-mediated protein folding
C0119_RS12825	COG2199	diguanylate cyclase activity
C0119_RS12825	COG2203	Gaf domain
C0119_RS12880	COG2815	serine threonine protein kinase
C0119_RS12880	COG0515	serine threonine protein kinase
C0119_RS12930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0119_RS12935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS12945	COG0612	Peptidase, M16
C0119_RS12950	COG3618	amidohydrolase
C0119_RS12970	COG3025	triphosphatase activity
C0119_RS12985	COG0352	thiamine-phosphate diphosphorylase activity
C0119_RS13030	COG1309	transcriptional regulator
C0119_RS13095	COG2391	methyltransferase activity
C0119_RS13105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0119_RS13110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0119_RS13120	COG0456	acetyltransferase
C0119_RS13125	COG2353	YceI-like domain
C0119_RS13130	COG0519	Catalyzes the synthesis of GMP from XMP
C0119_RS13130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0119_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS13150	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS13175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C0119_RS13175	COG0517	IMP dehydrogenase activity
C0119_RS13180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C0119_RS13190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C0119_RS13195	COG1137	ATPase activity
C0119_RS13225	COG0589	response to stress
C0119_RS13230	COG4122	O-methyltransferase activity
C0119_RS13240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C0119_RS13250	COG2203	Gaf domain
C0119_RS13250	COG5001	Diguanylate cyclase
C0119_RS13250	COG4251	negative regulation of phosphorylation
C0119_RS13250	COG3706	GGDEF domain
C0119_RS13285	COG2011	ABC-type metal ion transport system permease component
C0119_RS13290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0119_RS13295	COG1464	Belongs to the NlpA lipoprotein family
C0119_RS13310	COG0151	Belongs to the GarS family
C0119_RS13315	COG0138	bifunctional purine biosynthesis protein purh
C0119_RS13320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C0119_RS13350	COG0445	tRNA wobble uridine modification
C0119_RS13360	COG2814	Major facilitator Superfamily
C0119_RS13375	COG3852	Histidine kinase
C0119_RS13395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0119_RS13400	COG0575	Belongs to the CDS family
C0119_RS13415	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0119_RS13430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0119_RS13435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0119_RS13450	COG2137	regulation of response to DNA damage stimulus
C0119_RS13460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C0119_RS13465	COG1011	Hydrolase
C0119_RS13480	COG0268	Binds directly to 16S ribosomal RNA
C0119_RS13485	COG0702	epimerase
C0119_RS13490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0119_RS13495	COG0625	glutathione transferase activity
C0119_RS13500	COG2850	peptidyl-arginine hydroxylation
C0119_RS13510	COG0424	maF-like protein
C0119_RS13535	COG0697	spore germination
C0119_RS13565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0119_RS13570	COG3781	membrane
C0119_RS13590	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C0119_RS13590	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C0119_RS13590	COG0506	proline dehydrogenase activity
C0119_RS13600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0119_RS13605	COG1027	Aspartate ammonia-lyase
C0119_RS13645	COG0316	Belongs to the HesB IscA family
C0119_RS13650	COG0822	iron-sulfur transferase activity
C0119_RS13675	COG0776	regulation of translation
C0119_RS13680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0119_RS13700	COG1585	Membrane protein implicated in regulation of membrane protease activity
C0119_RS13710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0119_RS13730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0119_RS13735	COG0569	domain protein
C0119_RS13740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0119_RS13755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS13780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0119_RS13785	COG0542	response to heat
C0119_RS13800	COG0477	Major facilitator Superfamily
C0119_RS13820	COG0372	Belongs to the citrate synthase family
C0119_RS13835	COG1546	Belongs to the CinA family
C0119_RS13835	COG1058	Belongs to the CinA family
C0119_RS13845	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS13885	COG2814	Major facilitator Superfamily
C0119_RS13895	COG3706	GGDEF domain
C0119_RS13905	COG0439	Biotin carboxylase
C0119_RS13920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0119_RS13945	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C0119_RS13950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0119_RS13980	COG0596	Alpha beta hydrolase
C0119_RS14070	COG3550	peptidyl-serine autophosphorylation
C0119_RS14080	COG2072	flavoprotein involved in K transport
C0119_RS14090	COG2144	transferase activity, transferring acyl groups
C0119_RS14115	COG3604	Transcriptional regulator
C0119_RS14140	COG4221	oxidoreductase activity
C0119_RS14155	COG0642	Histidine kinase
C0119_RS14160	COG0745	RESPONSE REGULATOR receiver
C0119_RS14165	COG2194	sulfuric ester hydrolase activity
C0119_RS14180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS14205	COG0515	serine threonine protein kinase
C0119_RS14210	COG2116	formate transmembrane transporter activity
C0119_RS14215	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C0119_RS14235	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0119_RS14240	COG3845	ABC transporter
C0119_RS14270	COG0583	DNA-binding transcription factor activity
C0119_RS14285	COG1877	trehalose-phosphatase activity
C0119_RS14290	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C0119_RS14320	COG1944	ATP diphosphatase activity
C0119_RS14340	COG1309	transcriptional regulator
C0119_RS14345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0119_RS14375	COG2223	nitrite transmembrane transporter activity
C0119_RS14380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C0119_RS14385	COG4149	molybdate abc transporter
C0119_RS14390	COG0725	ABC transporter, periplasmic molybdate-binding protein
C0119_RS14395	COG0303	'Molybdopterin
C0119_RS14400	COG0315	cyclic pyranopterin monophosphate synthase activity
C0119_RS14400	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0119_RS14405	COG0314	molybdopterin synthase activity
C0119_RS14415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0119_RS14425	COG0243	molybdopterin cofactor binding
C0119_RS14430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS14435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS14440	COG2223	nitrite transmembrane transporter activity
C0119_RS14455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS14455	COG1116	anion transmembrane transporter activity
C0119_RS14460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0119_RS14465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0119_RS14485	COG1064	alcohol dehydrogenase
C0119_RS14510	COG0864	Transcriptional regulator
C0119_RS14520	COG0439	Biotin carboxylase
C0119_RS14535	COG0583	DNA-binding transcription factor activity
C0119_RS14540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0119_RS14585	COG1017	nitric oxide dioxygenase activity
C0119_RS14585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0119_RS14590	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS14595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0119_RS14605	COG2814	Major facilitator Superfamily
C0119_RS14610	COG0583	DNA-binding transcription factor activity
C0119_RS14615	COG4948	Mandelate Racemase Muconate Lactonizing
C0119_RS14620	COG4829	muconolactone delta-isomerase
C0119_RS14630	COG4638	Rieske (2fe-2S)
C0119_RS14635	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C0119_RS14640	COG0633	Ferredoxin
C0119_RS14640	COG0543	2 iron, 2 sulfur cluster binding
C0119_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS14650	COG3135	benzoate transporter
C0119_RS14655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0119_RS14660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0119_RS14665	COG0183	Belongs to the thiolase family
C0119_RS14670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0119_RS14690	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS14705	COG0831	urea catabolic process
C0119_RS14710	COG0829	nickel cation binding
C0119_RS14720	COG0830	nickel cation binding
C0119_RS14745	COG0789	Transcriptional regulator
C0119_RS14755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0119_RS14760	COG0640	Transcriptional regulator
C0119_RS14775	COG3619	membrane
C0119_RS14780	COG3122	Protein conserved in bacteria
C0119_RS14795	COG0668	transmembrane transport
C0119_RS14800	COG1132	(ABC) transporter
C0119_RS14805	COG2030	dehydratase
C0119_RS14815	COG0509	glycine decarboxylation via glycine cleavage system
C0119_RS14820	COG2814	Major facilitator Superfamily
C0119_RS14835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0119_RS14845	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C0119_RS14915	COG1525	nuclease
C0119_RS14935	COG2169	Transcriptional regulator
C0119_RS14940	COG1960	acyl-CoA dehydrogenase activity
C0119_RS14950	COG2207	Transcriptional regulator
C0119_RS14955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0119_RS14960	COG0730	response to heat
C0119_RS14965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0119_RS15020	COG1475	DNA binding
C0119_RS15025	COG1192	Involved in chromosome partitioning
C0119_RS15105	COG0789	Transcriptional regulator
C0119_RS15270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS15315	COG3284	Transcriptional regulator
C0119_RS15430	COG4372	Transposase
C0119_RS15465	COG1401	restriction endodeoxyribonuclease activity
C0119_RS15480	COG0659	secondary active sulfate transmembrane transporter activity
C0119_RS15485	COG0589	response to stress
C0119_RS15605	COG0604	alcohol dehydrogenase
C0119_RS15625	COG1063	alcohol dehydrogenase
C0119_RS15640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0119_RS15715	COG2814	Major facilitator Superfamily
C0119_RS15765	COG0789	Transcriptional regulator
C0119_RS15790	COG0582	viral genome integration into host DNA
C0119_RS15795	COG2369	cell adhesion
C0119_RS15820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0119_RS15890	COG1475	DNA binding
C0119_RS15895	COG1192	Involved in chromosome partitioning
C0119_RS15975	COG0789	Transcriptional regulator