locus-tag	class	description
C0119_RS00010	COG0592	DNA-directed DNA polymerase activity
C0119_RS00020	COG0187	DNA topoisomerase II activity
C0119_RS00035	COG1063	alcohol dehydrogenase
C0119_RS00095	COG0657	acetylesterase activity
C0119_RS00105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0119_RS00135	COG2814	Major facilitator Superfamily
C0119_RS00155	COG0693	protein deglycase activity
C0119_RS00165	COG1012	belongs to the aldehyde dehydrogenase family
C0119_RS00170	COG0733	neurotransmitter:sodium symporter activity
C0119_RS00180	COG0428	transporter
C0119_RS00205	COG0129	dihydroxy-acid dehydratase activity
C0119_RS00225	COG0583	DNA-binding transcription factor activity
C0119_RS00230	COG2233	PERMEase
C0119_RS00245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS00265	COG0783	Belongs to the Dps family
C0119_RS00280	COG0675	Transposase, IS605 OrfB family
C0119_RS00290	COG1064	alcohol dehydrogenase
C0119_RS00295	COG2818	Glycosylase
C0119_RS00310	COG1194	a g-specific adenine glycosylase
C0119_RS00325	COG0545	Peptidyl-prolyl cis-trans isomerase
C0119_RS00345	COG1596	polysaccharide export
C0119_RS00350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C0119_RS00375	COG0438	transferase activity, transferring glycosyl groups
C0119_RS00380	COG0438	transferase activity, transferring glycosyl groups
C0119_RS00385	COG0438	transferase activity, transferring glycosyl groups
C0119_RS00390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0119_RS00395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0119_RS00405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0119_RS00415	COG1088	dTDP-glucose 4,6-dehydratase activity
C0119_RS00475	COG0297	glycogen (starch) synthase activity
C0119_RS00485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0119_RS00490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0119_RS00505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0119_RS00515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0119_RS00555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0119_RS00565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C0119_RS00575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0119_RS00580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0119_RS00605	COG1484	DNA-dependent DNA replication
C0119_RS00625	COG3421	Type III restriction
C0119_RS00635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0119_RS00640	COG3002	Belongs to the UPF0753 family
C0119_RS00770	COG3756	Protein conserved in bacteria
C0119_RS00815	COG1192	Involved in chromosome partitioning
C0119_RS00830	COG0586	Pfam SNARE associated Golgi protein
C0119_RS00835	COG0519	Catalyzes the synthesis of GMP from XMP
C0119_RS00835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0119_RS00840	COG1715	Restriction endonuclease
C0119_RS00850	COG3706	GGDEF domain
C0119_RS00900	COG0534	Mate efflux family protein
C0119_RS00905	COG0436	Aminotransferase
C0119_RS00920	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS00930	COG2837	iron assimilation
C0119_RS00940	COG3123	guanosine phosphorylase activity
C0119_RS00950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0119_RS00955	COG1121	(ABC) transporter
C0119_RS01005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0119_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
C0119_RS01055	COG0386	Belongs to the glutathione peroxidase family
C0119_RS01060	COG0697	spore germination
C0119_RS01075	COG0758	DNA mediated transformation
C0119_RS01130	COG2814	Major facilitator Superfamily
C0119_RS01150	COG0477	Major facilitator Superfamily
C0119_RS01155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0119_RS01185	COG1253	flavin adenine dinucleotide binding
C0119_RS01195	COG2860	membrane
C0119_RS01200	COG0477	Major facilitator Superfamily
C0119_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS01225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0119_RS01260	COG0347	Belongs to the P(II) protein family
C0119_RS01265	COG0004	ammonium transporteR
C0119_RS01275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0119_RS01275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0119_RS01290	COG0586	Pfam SNARE associated Golgi protein
C0119_RS01310	COG0795	lipopolysaccharide-transporting ATPase activity
C0119_RS01315	COG0795	lipopolysaccharide-transporting ATPase activity
C0119_RS01320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C0119_RS01325	COG0793	Belongs to the peptidase S41A family
C0119_RS01335	COG5002	protein histidine kinase activity
C0119_RS01340	COG2197	response regulator
C0119_RS01350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0119_RS01360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0119_RS01365	COG4974	Belongs to the 'phage' integrase family
C0119_RS01390	COG0772	Belongs to the SEDS family
C0119_RS01400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0119_RS01405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0119_RS01410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C0119_RS01415	COG0494	nUDIX hydrolase
C0119_RS01420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0119_RS01430	COG1538	Outer membrane efflux protein
C0119_RS01455	COG1132	(ABC) transporter
C0119_RS01465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0119_RS01475	COG0497	DNA recombination
C0119_RS01480	COG3123	guanosine phosphorylase activity
C0119_RS01485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0119_RS01495	COG0237	dephospho-CoA kinase activity
C0119_RS01520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0119_RS01550	COG0779	Required for maturation of 30S ribosomal subunits
C0119_RS01555	COG0195	Participates in both transcription termination and antitermination
C0119_RS01565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0119_RS01570	COG1320	monovalent cation:proton antiporter activity
C0119_RS01575	COG2212	antiporter activity
C0119_RS01580	COG1863	multisubunit Na H antiporter MnhE subunit
C0119_RS01585	COG0651	ATP synthesis coupled electron transport
C0119_RS01590	COG1006	Multisubunit Na H antiporter MnhC subunit
C0119_RS01595	COG2111	Na H antiporter
C0119_RS01595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0119_RS01610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0119_RS01615	COG4221	oxidoreductase activity
C0119_RS01625	COG0488	(ABC) transporter
C0119_RS01670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0119_RS01690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0119_RS01695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0119_RS01700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0119_RS01705	COG2226	methyltransferase
C0119_RS01755	COG0070	glutamate synthase
C0119_RS01755	COG0067	glutamate synthase
C0119_RS01755	COG0069	glutamate synthase activity
C0119_RS01760	COG0493	'glutamate synthase
C0119_RS01765	COG1704	LemA family
C0119_RS01780	COG4969	Belongs to the N-Me-Phe pilin family
C0119_RS01790	COG3307	-O-antigen
C0119_RS01800	COG0675	Transposase, IS605 OrfB family
C0119_RS01815	COG0675	Transposase, IS605 OrfB family
C0119_RS01835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0119_RS01840	COG1758	RNA polymerase activity
C0119_RS01845	COG0194	GDP metabolic process
C0119_RS01890	COG0228	four-way junction DNA binding
C0119_RS01895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0119_RS01905	COG0335	large ribosomal subunit rRNA binding
C0119_RS01920	COG5380	lipid catabolic process
C0119_RS01925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0119_RS01950	COG5006	permease, DMT superfamily
C0119_RS01955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0119_RS01960	COG0277	FAD linked oxidase domain protein
C0119_RS01975	COG2814	Major facilitator Superfamily
C0119_RS01985	COG0628	permease
C0119_RS02005	COG2226	methyltransferase
C0119_RS02020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0119_RS02025	COG0254	rRNA binding
C0119_RS02030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0119_RS02045	COG0534	Mate efflux family protein
C0119_RS02055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0119_RS02065	COG1278	Cold shock
C0119_RS02070	COG1960	acyl-CoA dehydrogenase activity
C0119_RS02085	COG0408	coproporphyrinogen oxidase activity
C0119_RS02090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0119_RS02115	COG1127	ABC transporter
C0119_RS02120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0119_RS02125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0119_RS02130	COG2854	intermembrane phospholipid transfer
C0119_RS02140	COG0598	Magnesium transport protein CorA
C0119_RS02150	COG0494	nUDIX hydrolase
C0119_RS02155	COG1040	competence protein
C0119_RS02160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0119_RS02170	COG2937	Belongs to the GPAT DAPAT family
C0119_RS02175	COG1946	Acyl-CoA thioesterase
C0119_RS02180	COG1301	dicarboxylic acid transport
C0119_RS02200	COG1959	2 iron, 2 sulfur cluster binding
C0119_RS02210	COG0433	COG0433 Predicted ATPase
C0119_RS02215	COG0626	cystathionine gamma-synthase activity
C0119_RS02235	COG0088	Forms part of the polypeptide exit tunnel
C0119_RS02240	COG0089	rRNA binding
C0119_RS02250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0119_RS02300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0119_RS02305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0119_RS02315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0119_RS02340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0119_RS02350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0119_RS02355	COG0202	RNA polymerase activity
C0119_RS02360	COG0203	ribosomal protein L17
C0119_RS02365	COG2072	flavoprotein involved in K transport
C0119_RS02370	COG1960	acyl-CoA dehydrogenase activity
C0119_RS02375	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C0119_RS02410	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C0119_RS02415	COG0339	signal peptide processing
C0119_RS02425	COG0557	exoribonuclease II activity
C0119_RS02460	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0119_RS02470	COG2169	Transcriptional regulator
C0119_RS02480	COG1295	ribonuclease BN
C0119_RS02515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0119_RS02520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS02535	COG0183	Belongs to the thiolase family
C0119_RS02540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS02565	COG2009	succinate dehydrogenase
C0119_RS02585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C0119_RS02595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C0119_RS02630	COG0625	glutathione transferase activity
C0119_RS02635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS02660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS02705	COG1702	phosphate starvation-inducible protein PhoH
C0119_RS02710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0119_RS02715	COG1196	nuclear chromosome segregation
C0119_RS02715	COG0741	lytic transglycosylase activity
C0119_RS02715	COG0739	heme binding
C0119_RS02755	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C0119_RS02760	COG1183	phosphatidylcholine synthase activity
C0119_RS02800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS02830	COG1607	acyl-coa hydrolase
C0119_RS02860	COG2350	Protein conserved in bacteria
C0119_RS02880	COG3781	membrane
C0119_RS02885	COG2003	Belongs to the UPF0758 family
C0119_RS02890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0119_RS03065	COG0739	heme binding
C0119_RS03065	COG1196	nuclear chromosome segregation
C0119_RS03065	COG0741	lytic transglycosylase activity
C0119_RS03110	COG2814	Major facilitator Superfamily
C0119_RS03135	COG0004	ammonium transporteR
C0119_RS03150	COG3622	Belongs to the hyi family
C0119_RS03155	COG2084	Dehydrogenase
C0119_RS03160	COG1024	Enoyl-CoA hydratase
C0119_RS03165	COG0784	Response regulator, receiver
C0119_RS03165	COG2205	protein histidine kinase activity
C0119_RS03165	COG5002	protein histidine kinase activity
C0119_RS03185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0119_RS03195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0119_RS03205	COG1862	Preprotein translocase
C0119_RS03220	COG1704	LemA family
C0119_RS03230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C0119_RS03260	COG1960	acyl-CoA dehydrogenase activity
C0119_RS03265	COG1960	acyl-CoA dehydrogenase activity
C0119_RS03275	COG2205	protein histidine kinase activity
C0119_RS03280	COG0745	RESPONSE REGULATOR receiver
C0119_RS03300	COG1113	amino acid transport
C0119_RS03325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0119_RS03340	COG2096	Adenosyltransferase
C0119_RS03345	COG4206	TonB-dependent receptor
C0119_RS03385	COG0159	tryptophan synthase activity
C0119_RS03395	COG0285	dihydrofolate synthase activity
C0119_RS03410	COG0450	alkyl hydroperoxide reductase
C0119_RS03425	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0119_RS03430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0119_RS03505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0119_RS03510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0119_RS03535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0119_RS03540	COG1408	metallophosphoesterase
C0119_RS03550	COG0477	Major facilitator Superfamily
C0119_RS03555	COG1272	protein, Hemolysin III
C0119_RS03575	COG1024	Enoyl-CoA hydratase
C0119_RS03575	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0119_RS03580	COG0183	Belongs to the thiolase family
C0119_RS03585	COG2207	Transcriptional regulator
C0119_RS03590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0119_RS03595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS03610	COG0183	Belongs to the thiolase family
C0119_RS03630	COG0833	amino acid
C0119_RS03640	COG2233	PERMEase
C0119_RS03645	COG1217	gtp-binding protein TYPA
C0119_RS03655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0119_RS03690	COG0354	folic acid binding
C0119_RS03700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0119_RS03745	COG0564	pseudouridine synthase activity
C0119_RS03760	COG2824	Alkylphosphonate utilization operon protein PhnA
C0119_RS03775	COG0351	phosphomethylpyrimidine kinase
C0119_RS03775	COG0352	thiamine-phosphate diphosphorylase activity
C0119_RS03775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0119_RS03820	COG0431	NADPH-dependent FMN reductase
C0119_RS03825	COG0798	PFAM Bile acid sodium symporter
C0119_RS03830	COG0640	Transcriptional regulator
C0119_RS03840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0119_RS03850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0119_RS03850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0119_RS03855	COG0745	RESPONSE REGULATOR receiver
C0119_RS03860	COG2205	protein histidine kinase activity
C0119_RS03870	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0119_RS03890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C0119_RS03905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0119_RS03915	COG0713	ATP synthesis coupled electron transport
C0119_RS03920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0119_RS03925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0119_RS03950	COG0583	DNA-binding transcription factor activity
C0119_RS03965	COG0531	amino acid
C0119_RS03975	COG4302	ethanolamine ammonia-lyase activity
C0119_RS03985	COG0668	transmembrane transport
C0119_RS03990	COG2081	HI0933 family
C0119_RS04000	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C0119_RS04015	COG0004	ammonium transporteR
C0119_RS04045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0119_RS04045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0119_RS04060	COG0489	protein tyrosine kinase activity
C0119_RS04080	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS04125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS04150	COG0840	transmembrane signaling receptor activity
C0119_RS04240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C0119_RS04250	COG1289	transmembrane transporter activity
C0119_RS04255	COG2814	Major facilitator Superfamily
C0119_RS04265	COG0786	glutamate:sodium symporter activity
C0119_RS04270	COG1115	amino acid carrier protein
C0119_RS04280	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0119_RS04290	COG1607	acyl-coa hydrolase
C0119_RS04300	COG2814	Major facilitator Superfamily
C0119_RS04305	COG0583	DNA-binding transcription factor activity
C0119_RS04335	COG1285	pathogenesis
C0119_RS04345	COG4251	negative regulation of phosphorylation
C0119_RS04345	COG5001	Diguanylate cyclase
C0119_RS04345	COG3706	GGDEF domain
C0119_RS04345	COG2203	Gaf domain
C0119_RS04375	COG0242	peptide deformylase activity
C0119_RS04380	COG0393	Putative heavy-metal-binding
C0119_RS04385	COG0393	Putative heavy-metal-binding
C0119_RS04390	COG1538	Outer membrane efflux protein
C0119_RS04400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS04415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0119_RS04425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C0119_RS04435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0119_RS04440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0119_RS04440	COG1648	precorrin-2 dehydrogenase activity
C0119_RS04445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0119_RS04455	COG0531	amino acid
C0119_RS04470	COG0321	lipoyl(octanoyl) transferase activity
C0119_RS04475	COG2921	Belongs to the UPF0250 family
C0119_RS04480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0119_RS04505	COG0586	Pfam SNARE associated Golgi protein
C0119_RS04530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0119_RS04560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0119_RS04590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C0119_RS04600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0119_RS04605	COG0358	DNA primase activity
C0119_RS04615	COG0564	pseudouridine synthase activity
C0119_RS04640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0119_RS04675	COG0251	oxidation-reduction process
C0119_RS04680	COG1309	transcriptional regulator
C0119_RS04690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0119_RS04695	COG0505	Belongs to the CarA family
C0119_RS04720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C0119_RS04725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0119_RS04735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0119_RS04765	COG2851	Citrate transporter
C0119_RS04770	COG1253	flavin adenine dinucleotide binding
C0119_RS04790	COG2239	Acts as a magnesium transporter
C0119_RS04800	COG0501	Belongs to the peptidase M48B family
C0119_RS04805	COG0739	heme binding
C0119_RS04805	COG0741	lytic transglycosylase activity
C0119_RS04805	COG1196	nuclear chromosome segregation
C0119_RS04810	COG0037	tRNA processing
C0119_RS04820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C0119_RS04830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0119_RS04845	COG0583	DNA-binding transcription factor activity
C0119_RS04850	COG1960	acyl-CoA dehydrogenase activity
C0119_RS04855	COG2814	Major facilitator Superfamily
C0119_RS04860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0119_RS04870	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C0119_RS04895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0119_RS04900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C0119_RS04905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C0119_RS04910	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C0119_RS04945	COG1115	amino acid carrier protein
C0119_RS04950	COG1113	amino acid transport
C0119_RS04970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C0119_RS04985	COG1280	lysine exporter protein (LysE YggA)
C0119_RS05025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS05050	COG1671	Belongs to the UPF0178 family
C0119_RS05065	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0119_RS05070	COG1136	(ABC) transporter
C0119_RS05075	COG0658	competence protein
C0119_RS05075	COG2333	competence protein COMEC
C0119_RS05095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0119_RS05100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0119_RS05105	COG0628	permease
C0119_RS05145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0119_RS05160	COG2885	chlorophyll binding
C0119_RS05165	COG0823	Involved in the tonB-independent uptake of proteins
C0119_RS05185	COG0824	Thioesterase
C0119_RS05195	COG1473	amidohydrolase
C0119_RS05210	COG2255	four-way junction helicase activity
C0119_RS05225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0119_RS05225	COG0047	phosphoribosylformylglycinamidine synthase activity
C0119_RS05255	COG0778	Nitroreductase
C0119_RS05260	COG1024	Enoyl-CoA hydratase
C0119_RS05265	COG1056	cytidyltransferase-related domain
C0119_RS05265	COG1051	belongs to the nudix hydrolase family
C0119_RS05270	COG2353	YceI-like domain
C0119_RS05280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0119_RS05290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0119_RS05295	COG0602	queuosine metabolic process
C0119_RS05315	COG0583	DNA-binding transcription factor activity
C0119_RS05320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C0119_RS05325	COG4208	sulfate ABC transporter
C0119_RS05340	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0119_RS05345	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0119_RS05355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0119_RS05375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0119_RS05400	COG0571	ribonuclease III activity
C0119_RS05405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C0119_RS05415	COG1381	Involved in DNA repair and RecF pathway recombination
C0119_RS05420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C0119_RS05450	COG0436	Aminotransferase
C0119_RS05455	COG0024	Methionine aminopeptidase
C0119_RS05460	COG0052	Belongs to the universal ribosomal protein uS2 family
C0119_RS05485	COG2951	lytic endotransglycosylase activity
C0119_RS05500	COG0842	Transport permease protein
C0119_RS05505	COG1131	(ABC) transporter
C0119_RS05515	COG0582	viral genome integration into host DNA
C0119_RS05630	COG0640	Transcriptional regulator
C0119_RS05640	COG0798	PFAM Bile acid sodium symporter
C0119_RS05645	COG0431	NADPH-dependent FMN reductase
C0119_RS05665	COG0737	Belongs to the 5'-nucleotidase family
C0119_RS05675	COG3177	Filamentation induced by cAMP protein fic
C0119_RS05705	COG1278	Cold shock
C0119_RS05770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0119_RS05795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0119_RS05800	COG0826	peptidase U32
C0119_RS05805	COG0789	Transcriptional regulator
C0119_RS05820	COG1720	tRNA m6t6A37 methyltransferase activity
C0119_RS05830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0119_RS05845	COG0642	Histidine kinase
C0119_RS05855	COG0494	nUDIX hydrolase
C0119_RS05865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0119_RS05870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0119_RS05875	COG3139	Protein of unknown function (DUF1315)
C0119_RS05885	COG1301	dicarboxylic acid transport
C0119_RS05890	COG1960	acyl-CoA dehydrogenase activity
C0119_RS05895	COG0693	protein deglycase activity
C0119_RS05905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0119_RS05910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0119_RS05930	COG2252	PERMEase
C0119_RS05935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0119_RS05950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0119_RS05960	COG0527	aspartate kinase activity
C0119_RS05965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0119_RS06000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0119_RS06005	COG0501	Belongs to the peptidase M48B family
C0119_RS06020	COG1047	Peptidyl-prolyl cis-trans
C0119_RS06025	COG1252	NADH dehydrogenase
C0119_RS06050	COG2351	hydroxyisourate hydrolase activity
C0119_RS06070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C0119_RS06070	COG2755	lipolytic protein G-D-S-L family
C0119_RS06075	COG0436	Aminotransferase
C0119_RS06080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0119_RS06085	COG0386	Belongs to the glutathione peroxidase family
C0119_RS06095	COG0436	Aminotransferase
C0119_RS06100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C0119_RS06115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C0119_RS06135	COG0012	GTP binding
C0119_RS06140	COG2011	ABC-type metal ion transport system permease component
C0119_RS06145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0119_RS06150	COG1464	Belongs to the NlpA lipoprotein family
C0119_RS06230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0119_RS06230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0119_RS06235	COG1254	Belongs to the acylphosphatase family
C0119_RS06265	COG3634	alkyl hydroperoxide reductase activity
C0119_RS06315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0119_RS06340	COG0564	pseudouridine synthase activity
C0119_RS06345	COG0802	atpase or kinase
C0119_RS06350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0119_RS06360	COG1923	regulation of RNA biosynthetic process
C0119_RS06365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0119_RS06375	COG3178	'Phosphotransferase
C0119_RS06380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C0119_RS06390	COG1192	Involved in chromosome partitioning
C0119_RS06395	COG1475	DNA binding
C0119_RS06400	COG0811	peptide transport
C0119_RS06410	COG1132	(ABC) transporter
C0119_RS06415	COG1663	tetraacyldisaccharide 4'-kinase activity
C0119_RS06435	COG0084	hydrolase, TatD family'
C0119_RS06470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0119_RS06500	COG0776	regulation of translation
C0119_RS06520	COG2431	L-lysine efflux transmembrane transporter activity
C0119_RS06535	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C0119_RS06560	COG1253	flavin adenine dinucleotide binding
C0119_RS06590	COG0308	aminopeptidase N
C0119_RS06600	COG0589	response to stress
C0119_RS06605	COG0589	response to stress
C0119_RS06615	COG3135	benzoate transporter
C0119_RS06625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0119_RS06640	COG0183	Belongs to the thiolase family
C0119_RS06670	COG0824	Thioesterase
C0119_RS06675	COG1454	alcohol dehydrogenase
C0119_RS06680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0119_RS06700	COG0069	glutamate synthase activity
C0119_RS06710	COG2308	Evidence 4 Homologs of previously reported genes of
C0119_RS06720	COG1305	Transglutaminase-like
C0119_RS06735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0119_RS06755	COG0360	Binds together with S18 to 16S ribosomal RNA
C0119_RS06765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C0119_RS06770	COG1845	cytochrome c oxidase, subunit III
C0119_RS06775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0119_RS06780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0119_RS06805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0119_RS06820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0119_RS06825	COG2890	protein-(glutamine-N5) methyltransferase activity
C0119_RS06835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS06860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0119_RS06885	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C0119_RS06895	COG0729	surface antigen
C0119_RS06910	COG1570	exodeoxyribonuclease VII activity
C0119_RS06945	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS06960	COG0786	glutamate:sodium symporter activity
C0119_RS06985	COG0024	Methionine aminopeptidase
C0119_RS06990	COG0583	DNA-binding transcription factor activity
C0119_RS06995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0119_RS07010	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0119_RS07010	COG1902	pentaerythritol trinitrate reductase activity
C0119_RS07040	COG0148	phosphopyruvate hydratase activity
C0119_RS07045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C0119_RS07055	COG0772	Belongs to the SEDS family
C0119_RS07080	COG4890	Cyd operon protein YbgT
C0119_RS07085	COG1294	oxidase, subunit
C0119_RS07135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0119_RS07155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0119_RS07165	COG0133	tryptophan synthase activity
C0119_RS07170	COG0517	IMP dehydrogenase activity
C0119_RS07205	COG0552	protein localization to endoplasmic reticulum
C0119_RS07285	COG1960	acyl-CoA dehydrogenase activity
C0119_RS07290	COG1960	acyl-CoA dehydrogenase activity
C0119_RS07345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0119_RS07350	COG0730	response to heat
C0119_RS07355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0119_RS07360	COG2207	Transcriptional regulator
C0119_RS07370	COG1960	acyl-CoA dehydrogenase activity
C0119_RS07375	COG2169	Transcriptional regulator
C0119_RS07395	COG1525	nuclease
C0119_RS07465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C0119_RS07475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0119_RS07490	COG2814	Major facilitator Superfamily
C0119_RS07495	COG0509	glycine decarboxylation via glycine cleavage system
C0119_RS07505	COG2030	dehydratase
C0119_RS07510	COG1132	(ABC) transporter
C0119_RS07515	COG0668	transmembrane transport
C0119_RS07530	COG3122	Protein conserved in bacteria
C0119_RS07535	COG3619	membrane
C0119_RS07550	COG0640	Transcriptional regulator
C0119_RS07555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0119_RS07565	COG0789	Transcriptional regulator
C0119_RS07590	COG0830	nickel cation binding
C0119_RS07600	COG0829	nickel cation binding
C0119_RS07605	COG0831	urea catabolic process
C0119_RS07625	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS07645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0119_RS07650	COG0183	Belongs to the thiolase family
C0119_RS07655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0119_RS07660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0119_RS07665	COG3135	benzoate transporter
C0119_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS07675	COG0543	2 iron, 2 sulfur cluster binding
C0119_RS07675	COG0633	Ferredoxin
C0119_RS07680	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C0119_RS07685	COG4638	Rieske (2fe-2S)
C0119_RS07695	COG4829	muconolactone delta-isomerase
C0119_RS07700	COG4948	Mandelate Racemase Muconate Lactonizing
C0119_RS07705	COG0583	DNA-binding transcription factor activity
C0119_RS07710	COG2814	Major facilitator Superfamily
C0119_RS07720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0119_RS07725	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS07730	COG1017	nitric oxide dioxygenase activity
C0119_RS07730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0119_RS07775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0119_RS07780	COG0583	DNA-binding transcription factor activity
C0119_RS07795	COG0439	Biotin carboxylase
C0119_RS07805	COG0864	Transcriptional regulator
C0119_RS07830	COG1064	alcohol dehydrogenase
C0119_RS07850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0119_RS07855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0119_RS07860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS07860	COG1116	anion transmembrane transporter activity
C0119_RS07875	COG2223	nitrite transmembrane transporter activity
C0119_RS07880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS07885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS07890	COG0243	molybdopterin cofactor binding
C0119_RS07900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0119_RS07910	COG0314	molybdopterin synthase activity
C0119_RS07915	COG0315	cyclic pyranopterin monophosphate synthase activity
C0119_RS07915	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0119_RS07920	COG0303	'Molybdopterin
C0119_RS07925	COG0725	ABC transporter, periplasmic molybdate-binding protein
C0119_RS07930	COG4149	molybdate abc transporter
C0119_RS07935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C0119_RS07940	COG2223	nitrite transmembrane transporter activity
C0119_RS07970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0119_RS07975	COG1309	transcriptional regulator
C0119_RS07995	COG1944	ATP diphosphatase activity
C0119_RS08025	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C0119_RS08030	COG1877	trehalose-phosphatase activity
C0119_RS08040	COG0583	DNA-binding transcription factor activity
C0119_RS08070	COG3845	ABC transporter
C0119_RS08075	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0119_RS08095	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C0119_RS08100	COG2116	formate transmembrane transporter activity
C0119_RS08105	COG0515	serine threonine protein kinase
C0119_RS08130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS08145	COG2194	sulfuric ester hydrolase activity
C0119_RS08150	COG0745	RESPONSE REGULATOR receiver
C0119_RS08155	COG0642	Histidine kinase
C0119_RS08170	COG4221	oxidoreductase activity
C0119_RS08195	COG3604	Transcriptional regulator
C0119_RS08220	COG2144	transferase activity, transferring acyl groups
C0119_RS08230	COG2072	flavoprotein involved in K transport
C0119_RS08240	COG3550	peptidyl-serine autophosphorylation
C0119_RS08330	COG0596	Alpha beta hydrolase
C0119_RS08360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0119_RS08365	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C0119_RS08390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0119_RS08405	COG0439	Biotin carboxylase
C0119_RS08415	COG3706	GGDEF domain
C0119_RS08425	COG2814	Major facilitator Superfamily
C0119_RS08465	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS08475	COG1546	Belongs to the CinA family
C0119_RS08475	COG1058	Belongs to the CinA family
C0119_RS08490	COG0372	Belongs to the citrate synthase family
C0119_RS08510	COG0477	Major facilitator Superfamily
C0119_RS08525	COG0542	response to heat
C0119_RS08530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0119_RS08555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS08570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0119_RS08575	COG0569	domain protein
C0119_RS08580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0119_RS08600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0119_RS08610	COG1585	Membrane protein implicated in regulation of membrane protease activity
C0119_RS08630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0119_RS08635	COG0776	regulation of translation
C0119_RS08660	COG0822	iron-sulfur transferase activity
C0119_RS08665	COG0316	Belongs to the HesB IscA family
C0119_RS08705	COG1027	Aspartate ammonia-lyase
C0119_RS08710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0119_RS08720	COG0506	proline dehydrogenase activity
C0119_RS08720	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C0119_RS08720	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C0119_RS08740	COG3781	membrane
C0119_RS08745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0119_RS08775	COG0697	spore germination
C0119_RS08800	COG0424	maF-like protein
C0119_RS08810	COG2850	peptidyl-arginine hydroxylation
C0119_RS08815	COG0625	glutathione transferase activity
C0119_RS08820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0119_RS08825	COG0702	epimerase
C0119_RS08830	COG0268	Binds directly to 16S ribosomal RNA
C0119_RS08845	COG1011	Hydrolase
C0119_RS08850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C0119_RS08860	COG2137	regulation of response to DNA damage stimulus
C0119_RS08875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0119_RS08880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0119_RS08895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0119_RS08910	COG0575	Belongs to the CDS family
C0119_RS08915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0119_RS08935	COG3852	Histidine kinase
C0119_RS08955	COG0445	tRNA wobble uridine modification
C0119_RS08985	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C0119_RS08990	COG0138	bifunctional purine biosynthesis protein purh
C0119_RS08995	COG0151	Belongs to the GarS family
C0119_RS09010	COG1464	Belongs to the NlpA lipoprotein family
C0119_RS09015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0119_RS09020	COG2011	ABC-type metal ion transport system permease component
C0119_RS09055	COG2203	Gaf domain
C0119_RS09055	COG4251	negative regulation of phosphorylation
C0119_RS09055	COG5001	Diguanylate cyclase
C0119_RS09055	COG3706	GGDEF domain
C0119_RS09065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C0119_RS09075	COG4122	O-methyltransferase activity
C0119_RS09080	COG0589	response to stress
C0119_RS09110	COG1137	ATPase activity
C0119_RS09115	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C0119_RS09125	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C0119_RS09130	COG0517	IMP dehydrogenase activity
C0119_RS09130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C0119_RS09155	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS09175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0119_RS09175	COG0519	Catalyzes the synthesis of GMP from XMP
C0119_RS09180	COG2353	YceI-like domain
C0119_RS09185	COG0456	acetyltransferase
C0119_RS09195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0119_RS09200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0119_RS09210	COG2391	methyltransferase activity
C0119_RS09275	COG1309	transcriptional regulator
C0119_RS09320	COG0352	thiamine-phosphate diphosphorylase activity
C0119_RS09335	COG3025	triphosphatase activity
C0119_RS09355	COG3618	amidohydrolase
C0119_RS09360	COG0612	Peptidase, M16
C0119_RS09370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS09375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0119_RS09425	COG2815	serine threonine protein kinase
C0119_RS09425	COG0515	serine threonine protein kinase
C0119_RS09480	COG2203	Gaf domain
C0119_RS09480	COG2199	diguanylate cyclase activity
C0119_RS09505	COG4783	chaperone-mediated protein folding
C0119_RS09560	COG0778	Nitroreductase
C0119_RS09570	COG0513	Belongs to the DEAD box helicase family
C0119_RS09575	COG1278	Cold shock
C0119_RS09590	COG2363	Small membrane protein
C0119_RS09610	COG0659	secondary active sulfate transmembrane transporter activity
C0119_RS09615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0119_RS09640	COG3047	cAMP biosynthetic process
C0119_RS09640	COG2885	chlorophyll binding
C0119_RS09650	COG0540	Belongs to the ATCase OTCase family
C0119_RS09670	COG0667	Aldo Keto reductase
C0119_RS09680	COG1765	OsmC-like protein
C0119_RS09685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0119_RS09710	COG1136	(ABC) transporter
C0119_RS09730	COG0281	malic enzyme
C0119_RS09755	COG0714	Associated with various cellular activities
C0119_RS09760	COG2879	small protein
C0119_RS09765	COG1966	Carbon starvation protein
C0119_RS09770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0119_RS09810	COG1067	ATP-dependent peptidase activity
C0119_RS09815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0119_RS09820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0119_RS09825	COG0583	DNA-binding transcription factor activity
C0119_RS09850	COG1686	Belongs to the peptidase S11 family
C0119_RS09855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0119_RS09915	COG0616	signal peptide processing
C0119_RS09925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0119_RS09935	COG0573	inorganic phosphate transmembrane transporter activity
C0119_RS09945	COG0076	glutamate decarboxylase activity
C0119_RS09950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0119_RS09960	COG0671	phosphoesterase, PA-phosphatase related
C0119_RS09965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0119_RS09975	COG2814	Major facilitator Superfamily
C0119_RS09980	COG1733	regulation of RNA biosynthetic process
C0119_RS10010	COG0556	nucleotide-excision repair
C0119_RS10020	COG2199	diguanylate cyclase activity
C0119_RS10050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS10055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0119_RS10060	COG1960	acyl-CoA dehydrogenase activity
C0119_RS10070	COG2084	Dehydrogenase
C0119_RS10075	COG2233	PERMEase
C0119_RS10080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS10085	COG0251	oxidation-reduction process
C0119_RS10090	COG1335	isochorismatase
C0119_RS10110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0119_RS10120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0119_RS10160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0119_RS10175	COG0174	glutamine synthetase
C0119_RS10180	COG0512	Glutamine amidotransferase of anthranilate synthase
C0119_RS10185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0119_RS10200	COG0302	gtp cyclohydrolase
C0119_RS10215	COG3706	GGDEF domain
C0119_RS10230	COG3739	integral membrane protein
C0119_RS10245	COG1741	Belongs to the pirin family
C0119_RS10280	COG0640	Transcriptional regulator
C0119_RS10295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0119_RS10310	COG0642	Histidine kinase
C0119_RS10320	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0119_RS10320	COG1902	pentaerythritol trinitrate reductase activity
C0119_RS10330	COG0277	FAD linked oxidase domain protein
C0119_RS10340	COG2186	Transcriptional regulator
C0119_RS10345	COG1620	l-lactate permease
C0119_RS10355	COG3706	GGDEF domain
C0119_RS10355	COG2203	Gaf domain
C0119_RS10355	COG4251	negative regulation of phosphorylation
C0119_RS10355	COG5001	Diguanylate cyclase
C0119_RS10360	COG0418	dihydroorotase activity
C0119_RS10365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0119_RS10375	COG4771	TonB-dependent receptor
C0119_RS10385	COG0833	amino acid
C0119_RS10425	COG4172	Belongs to the ABC transporter superfamily
C0119_RS10430	COG4239	(ABC) transporter, permease
C0119_RS10435	COG4174	ABC transporter (Permease)
C0119_RS10440	COG4166	transmembrane transport
C0119_RS10445	COG1388	LysM domain
C0119_RS10445	COG0741	lytic transglycosylase activity
C0119_RS10465	COG0657	acetylesterase activity
C0119_RS10495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0119_RS10500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0119_RS10515	COG2155	Conserved Protein
C0119_RS10525	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS10530	COG0006	proline dipeptidase activity
C0119_RS10565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0119_RS10575	COG2234	aminopeptidase activity
C0119_RS10585	COG3384	dioxygenase
C0119_RS10595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0119_RS10600	COG2878	Part of a membrane complex involved in electron transport
C0119_RS10605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0119_RS10630	COG0768	penicillin binding
C0119_RS10635	COG0742	ribosomal rna small subunit methyltransferase
C0119_RS10710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0119_RS10775	COG2268	Band 7 protein
C0119_RS10780	COG1649	PFAM Uncharacterised BCR, COG1649
C0119_RS10780	COG0726	polysaccharide deacetylase
C0119_RS10790	COG1215	transferase activity, transferring glycosyl groups
C0119_RS10795	COG1649	PFAM Uncharacterised BCR, COG1649
C0119_RS10795	COG0726	polysaccharide deacetylase
C0119_RS10805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0119_RS10815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0119_RS10830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0119_RS10835	COG1053	succinate dehydrogenase
C0119_RS10840	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C0119_RS10860	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS10865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS10865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0119_RS10900	COG2321	neutral zinc metallopeptidase
C0119_RS10905	COG2354	Protein conserved in bacteria
C0119_RS10925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0119_RS10930	COG1773	rubredoxin
C0119_RS10935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0119_RS10945	COG0583	DNA-binding transcription factor activity
C0119_RS10955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0119_RS10965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C0119_RS10970	COG4181	ATPase activity
C0119_RS11015	COG0306	phosphate transporter
C0119_RS11045	COG2376	Dihydroxyacetone kinase
C0119_RS11050	COG2066	Belongs to the glutaminase family
C0119_RS11055	COG0300	oxidoreductase activity
C0119_RS11065	COG0525	valine-tRNA ligase activity
C0119_RS11075	COG2852	Protein conserved in bacteria
C0119_RS11090	COG2323	membrane
C0119_RS11095	COG0546	phosphoglycolate phosphatase activity
C0119_RS11130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0119_RS11135	COG0142	geranyltranstransferase activity
C0119_RS11140	COG2828	Protein conserved in bacteria
C0119_RS11145	COG1113	amino acid transport
C0119_RS11175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0119_RS11180	COG1530	ribonuclease E activity
C0119_RS11190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C0119_RS11195	COG1792	Involved in formation and maintenance of cell shape
C0119_RS11200	COG1077	Cell shape determining protein MreB Mrl
C0119_RS11205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0119_RS11215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0119_RS11240	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C0119_RS11255	COG1294	oxidase, subunit
C0119_RS11280	COG4106	trans-aconitate 2-methyltransferase activity
C0119_RS11295	COG0596	Alpha beta hydrolase
C0119_RS11300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0119_RS11320	COG1113	amino acid transport
C0119_RS11325	COG1448	Aminotransferase
C0119_RS11340	COG0625	glutathione transferase activity
C0119_RS11355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0119_RS11360	COG3177	Filamentation induced by cAMP protein fic
C0119_RS11385	COG3300	MHYT domain
C0119_RS11385	COG5001	Diguanylate cyclase
C0119_RS11430	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS11445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0119_RS11490	COG0582	viral genome integration into host DNA
C0119_RS11505	COG2050	protein possibly involved in aromatic compounds catabolism
C0119_RS11530	COG0420	3'-5' exonuclease activity
C0119_RS11560	COG0735	belongs to the Fur family
C0119_RS11565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0119_RS11570	COG2914	Belongs to the UPF0125 (RnfH) family
C0119_RS11585	COG0121	glutamine amidotransferase
C0119_RS11595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0119_RS11600	COG0756	dUTP diphosphatase activity
C0119_RS11605	COG0210	DNA helicase
C0119_RS11610	COG2885	chlorophyll binding
C0119_RS11615	COG0204	Acyl-transferase
C0119_RS11650	COG0492	ferredoxin-NADP+ reductase activity
C0119_RS11655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0119_RS11665	COG0456	acetyltransferase
C0119_RS11675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0119_RS11690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0119_RS11705	COG1981	membrane
C0119_RS11710	COG1113	amino acid transport
C0119_RS11715	COG0251	oxidation-reduction process
C0119_RS11735	COG1652	LysM domain
C0119_RS11740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0119_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS11760	COG1399	metal-binding, possibly nucleic acid-binding protein
C0119_RS11765	COG3101	peptidyl-lysine hydroxylation
C0119_RS11770	COG0009	L-threonylcarbamoyladenylate synthase
C0119_RS11790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0119_RS11795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0119_RS11810	COG2193	ferroxidase activity
C0119_RS11815	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C0119_RS11820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0119_RS11830	COG1196	nuclear chromosome segregation
C0119_RS11840	COG0730	response to heat
C0119_RS11845	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C0119_RS11845	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C0119_RS11855	COG3545	Serine hydrolase
C0119_RS11860	COG3545	Serine hydrolase
C0119_RS11865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0119_RS11880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0119_RS11890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0119_RS11900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0119_RS11915	COG4269	membrane
C0119_RS11935	COG1968	undecaprenyl-diphosphatase activity
C0119_RS11940	COG1214	PFAM Peptidase M22, glycoprotease
C0119_RS11950	COG0494	nUDIX hydrolase
C0119_RS11965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0119_RS11990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0119_RS11995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0119_RS12000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C0119_RS12005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0119_RS12010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0119_RS12015	COG0625	glutathione transferase activity
C0119_RS12020	COG2969	positive regulation of protein catabolic process
C0119_RS12075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS12080	COG1764	response to oxidative stress
C0119_RS12130	COG0037	tRNA processing
C0119_RS12140	COG0248	Ppx GppA phosphatase
C0119_RS12170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0119_RS12200	COG1238	metal cluster binding
C0119_RS12210	COG0625	glutathione transferase activity
C0119_RS12225	COG0675	Transposase, IS605 OrfB family
C0119_RS12235	COG0546	phosphoglycolate phosphatase activity
C0119_RS12260	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS12280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0119_RS12370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0119_RS12390	COG1660	Displays ATPase and GTPase activities
C0119_RS12405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0119_RS12410	COG0617	tRNA 3'-terminal CCA addition
C0119_RS12415	COG1555	photosystem II stabilization
C0119_RS12420	COG3956	TIGRFAM MazG family protein
C0119_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS12440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0119_RS12450	COG0124	histidyl-tRNA synthetase
C0119_RS12460	COG1426	Protein conserved in bacteria
C0119_RS12480	COG2975	iron-sulfur cluster assembly
C0119_RS12510	COG2826	transposase and inactivated derivatives, IS30 family
C0119_RS12520	COG0440	acetolactate synthase activity
C0119_RS12525	COG0028	Belongs to the TPP enzyme family
C0119_RS12550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0119_RS12555	COG0577	efflux transmembrane transporter activity
C0119_RS12555	COG1136	(ABC) transporter
C0119_RS12560	COG1538	Outer membrane efflux protein
C0119_RS12570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C0119_RS12580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0119_RS12585	COG1162	GTPase activity
C0119_RS12615	COG0084	hydrolase, TatD family'
C0119_RS12630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C0119_RS12645	COG0793	Belongs to the peptidase S41A family
C0119_RS12670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0119_RS12675	COG0280	phosphate acetyltransferase
C0119_RS12675	COG0857	belongs to the CobB CobQ family
C0119_RS12685	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C0119_RS12685	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C0119_RS12700	COG0740	serine-type endopeptidase activity
C0119_RS12710	COG4774	siderophore transport
C0119_RS12715	COG4774	siderophore transport
C0119_RS12720	COG3128	pkhd-type hydroxylase
C0119_RS12730	COG4774	siderophore transport
C0119_RS12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0119_RS12740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0119_RS12745	COG2813	Specifically methylates the guanine in position
C0119_RS12745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0119_RS12795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0119_RS12800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C0119_RS12835	COG0788	formyltetrahydrofolate deformylase activity
C0119_RS12860	COG4651	solute:proton antiporter activity
C0119_RS12860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0119_RS12880	COG0724	RNA recognition motif
C0119_RS12885	COG0210	DNA helicase
C0119_RS12890	COG1929	Belongs to the glycerate kinase type-1 family
C0119_RS12920	COG2900	Belongs to the SlyX family
C0119_RS12925	COG0488	(ABC) transporter
C0119_RS12930	COG1560	Kdo2-lipid A biosynthetic process
C0119_RS12965	COG0252	asparaginase activity
C0119_RS12995	COG0473	3-isopropylmalate dehydrogenase activity
C0119_RS13010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0119_RS13055	COG1960	acyl-CoA dehydrogenase activity
C0119_RS13060	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C0119_RS13075	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0119_RS13080	COG3384	dioxygenase
C0119_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS13100	COG4638	Rieske (2fe-2S)
C0119_RS13105	COG0583	DNA-binding transcription factor activity
C0119_RS13140	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C0119_RS13145	COG3971	2-oxopent-4-enoate hydratase activity
C0119_RS13150	COG0546	phosphoglycolate phosphatase activity
C0119_RS13165	COG1530	ribonuclease E activity
C0119_RS13170	COG0318	PFAM AMP-dependent synthetase and ligase
C0119_RS13195	COG1983	PspC domain protein
C0119_RS13205	COG0471	metal ion transport
C0119_RS13225	COG0751	glycine-tRNA ligase activity
C0119_RS13245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0119_RS13285	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C0119_RS13300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0119_RS13315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0119_RS13325	COG0644	oxidoreductase
C0119_RS13325	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C0119_RS13350	COG4535	Mg2 and Co2 transporter CorC
C0119_RS13355	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0119_RS13375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0119_RS13385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0119_RS13400	COG0789	Transcriptional regulator
C0119_RS13405	COG2841	Protein conserved in bacteria
C0119_RS13410	COG1185	polyribonucleotide nucleotidyltransferase activity
C0119_RS13415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0119_RS13425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0119_RS13430	COG1074	ATP-dependent DNA helicase activity
C0119_RS13435	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C0119_RS13470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0119_RS13500	COG0427	acetyl-CoA hydrolase
C0119_RS13510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0119_RS13540	COG0326	Molecular chaperone. Has ATPase activity
C0119_RS13555	COG2056	Na+-H+ antiporter family
C0119_RS13585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0119_RS13590	COG0085	RNA polymerase activity
C0119_RS13605	COG0081	regulation of translation
C0119_RS13610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0119_RS13630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0119_RS13660	COG0546	phosphoglycolate phosphatase activity
C0119_RS13690	COG0824	Thioesterase
C0119_RS13710	COG0181	hydroxymethylbilane synthase activity
C0119_RS13720	COG3275	phosphorelay sensor kinase activity
C0119_RS13740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0119_RS13765	COG3706	GGDEF domain
C0119_RS13770	COG1024	Enoyl-CoA hydratase
C0119_RS13770	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0119_RS13830	COG0131	Imidazoleglycerol-phosphate dehydratase
C0119_RS13835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0119_RS13890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0119_RS13925	COG3158	transport of potassium into the cell
C0119_RS13955	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C0119_RS13985	COG2814	Major facilitator Superfamily
C0119_RS13995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0119_RS13995	COG0351	phosphomethylpyrimidine kinase
C0119_RS13995	COG0352	thiamine-phosphate diphosphorylase activity
C0119_RS14000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0119_RS14005	COG3706	GGDEF domain
C0119_RS14020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0119_RS14030	COG3162	membrane
C0119_RS14035	COG0784	Response regulator, receiver
C0119_RS14035	COG2205	protein histidine kinase activity
C0119_RS14050	COG0431	NADPH-dependent FMN reductase
C0119_RS14060	COG0307	riboflavin synthase, alpha
C0119_RS14075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0119_RS14085	COG0668	transmembrane transport
C0119_RS14090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0119_RS14095	COG1519	Transferase
C0119_RS14100	COG1902	pentaerythritol trinitrate reductase activity
C0119_RS14105	COG0640	Transcriptional regulator
C0119_RS14125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C0119_RS14135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0119_RS14150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0119_RS14150	COG0426	domain, Protein
C0119_RS14155	COG2119	membrane
C0119_RS14200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0119_RS14225	COG0189	ligase activity
C0119_RS14240	COG2132	Multicopper oxidase
C0119_RS14255	COG1278	Cold shock
C0119_RS14265	COG0708	Exodeoxyribonuclease III
C0119_RS14270	COG1393	Belongs to the ArsC family
C0119_RS14325	COG2233	PERMEase
C0119_RS14340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0119_RS14345	COG4266	Belongs to the allantoicase family
C0119_RS14370	COG0784	Response regulator, receiver
C0119_RS14370	COG2205	protein histidine kinase activity
C0119_RS14395	COG0410	ABC transporter
C0119_RS14400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS14425	COG3150	esterase
C0119_RS14435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0119_RS14440	COG2918	glutathione biosynthetic process
C0119_RS14455	COG2733	membrane
C0119_RS14515	COG3830	Belongs to the UPF0237 family
C0119_RS14515	COG0560	Phosphoserine phosphatase
C0119_RS14525	COG0385	Bile acid
C0119_RS14530	COG1335	isochorismatase
C0119_RS14540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0119_RS14550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0119_RS14555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0119_RS14560	COG3300	MHYT domain
C0119_RS14560	COG5001	Diguanylate cyclase
C0119_RS14565	COG2983	Belongs to the UPF0260 family
C0119_RS14570	COG5487	UPF0391 membrane protein
C0119_RS14580	COG3023	N-Acetylmuramoyl-L-alanine amidase
C0119_RS14590	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0119_RS14595	COG1309	transcriptional regulator
C0119_RS14600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0119_RS14620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0119_RS14625	COG0546	phosphoglycolate phosphatase activity
C0119_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
C0119_RS14650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C0119_RS14650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0119_RS14660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0119_RS14665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0119_RS14670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0119_RS14675	COG1116	anion transmembrane transporter activity
C0119_RS14680	COG1309	transcriptional regulator
C0119_RS14690	COG0196	riboflavin kinase activity
C0119_RS14695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0119_RS14705	COG1047	Peptidyl-prolyl cis-trans
C0119_RS14715	COG2133	pyrroloquinoline quinone binding
C0119_RS14750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0119_RS14755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C0119_RS14760	COG2951	lytic endotransglycosylase activity
C0119_RS14765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0119_RS14780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0119_RS14805	COG2388	GCN5-related N-acetyl-transferase
C0119_RS14810	COG2814	Major facilitator Superfamily
C0119_RS14815	COG0861	Integral membrane protein TerC family
C0119_RS14820	COG0402	S-adenosylhomocysteine deaminase activity
C0119_RS14860	COG0706	membrane insertase activity
C0119_RS14865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0119_RS14870	COG0594	ribonuclease P activity
C0119_RS14950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0119_RS14965	COG1063	alcohol dehydrogenase
C0119_RS14985	COG0604	alcohol dehydrogenase
C0119_RS15105	COG0589	response to stress
C0119_RS15110	COG0659	secondary active sulfate transmembrane transporter activity
C0119_RS15125	COG1401	restriction endodeoxyribonuclease activity
C0119_RS15160	COG4372	Transposase
C0119_RS15270	COG3284	Transcriptional regulator
C0119_RS15315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0119_RS15480	COG0789	Transcriptional regulator
C0119_RS15560	COG1192	Involved in chromosome partitioning
C0119_RS15565	COG1475	DNA binding
C0119_RS15635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0119_RS15660	COG2369	cell adhesion
C0119_RS15665	COG0582	viral genome integration into host DNA
C0119_RS15690	COG0789	Transcriptional regulator
C0119_RS15740	COG2814	Major facilitator Superfamily