locus-tag	class	description
IC776_RS00010	COG0592	DNA-directed DNA polymerase activity
IC776_RS00020	COG0187	DNA topoisomerase II activity
IC776_RS00030	COG0586	Pfam SNARE associated Golgi protein
IC776_RS00035	COG0488	(ABC) transporter
IC776_RS00060	COG0596	Alpha beta hydrolase
IC776_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IC776_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IC776_RS00115	COG1047	Peptidyl-prolyl cis-trans
IC776_RS00125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IC776_RS00130	COG0196	riboflavin kinase activity
IC776_RS00140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IC776_RS00145	COG1309	transcriptional regulator
IC776_RS00150	COG1116	anion transmembrane transporter activity
IC776_RS00155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC776_RS00160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC776_RS00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC776_RS00170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC776_RS00175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IC776_RS00175	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IC776_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS00195	COG0546	phosphoglycolate phosphatase activity
IC776_RS00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
IC776_RS00280	COG1596	polysaccharide export
IC776_RS00285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IC776_RS00295	COG1091	dTDP-4-dehydrorhamnose reductase activity
IC776_RS00300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IC776_RS00310	COG2244	polysaccharide biosynthetic process
IC776_RS00315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IC776_RS00340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IC776_RS00345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IC776_RS00365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IC776_RS00375	COG2186	Transcriptional regulator
IC776_RS00390	COG1448	Aminotransferase
IC776_RS00400	COG1802	Transcriptional regulator
IC776_RS00415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IC776_RS00475	COG0564	pseudouridine synthase activity
IC776_RS00515	COG0251	oxidation-reduction process
IC776_RS00520	COG1113	amino acid transport
IC776_RS00525	COG1113	amino acid transport
IC776_RS00545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC776_RS00550	COG1960	acyl-CoA dehydrogenase activity
IC776_RS00555	COG1024	Enoyl-CoA hydratase
IC776_RS00560	COG1024	Enoyl-CoA hydratase
IC776_RS00565	COG0477	Major facilitator Superfamily
IC776_RS00570	COG3916	Acyl-homoserine-lactone synthase
IC776_RS00580	COG2197	response regulator
IC776_RS00590	COG1960	acyl-CoA dehydrogenase activity
IC776_RS00595	COG3321	synthase
IC776_RS00595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IC776_RS00595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IC776_RS00595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IC776_RS00635	COG0271	Belongs to the BolA IbaG family
IC776_RS00645	COG1192	Involved in chromosome partitioning
IC776_RS00660	COG0586	Pfam SNARE associated Golgi protein
IC776_RS00665	COG2259	Doxx family
IC776_RS00670	COG4399	Belongs to the UPF0754 family
IC776_RS00670	COG4399	Belongs to the UPF0754 family
IC776_RS00675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC776_RS00675	COG0519	Catalyzes the synthesis of GMP from XMP
IC776_RS00680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC776_RS00690	COG0735	belongs to the Fur family
IC776_RS00725	COG0281	malic enzyme
IC776_RS00735	COG2837	iron assimilation
IC776_RS00740	COG1280	lysine exporter protein (LysE YggA)
IC776_RS00745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IC776_RS00750	COG1121	(ABC) transporter
IC776_RS00800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IC776_RS00805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IC776_RS00815	COG0386	Belongs to the glutathione peroxidase family
IC776_RS00830	COG1309	transcriptional regulator
IC776_RS00835	COG0697	spore germination
IC776_RS00845	COG0758	DNA mediated transformation
IC776_RS00880	COG1309	transcriptional regulator
IC776_RS00915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC776_RS00930	COG0655	NAD(P)H dehydrogenase (quinone) activity
IC776_RS00965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IC776_RS00975	COG2814	Major facilitator Superfamily
IC776_RS00985	COG1253	flavin adenine dinucleotide binding
IC776_RS00995	COG2860	membrane
IC776_RS01000	COG0477	Major facilitator Superfamily
IC776_RS01010	COG0318	PFAM AMP-dependent synthetase and ligase
IC776_RS01025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IC776_RS01040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC776_RS01045	COG0235	Class ii aldolase
IC776_RS01050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC776_RS01055	COG0431	NADPH-dependent FMN reductase
IC776_RS01060	COG0606	chelatase, subunit chli
IC776_RS01100	COG0589	response to stress
IC776_RS01105	COG0659	secondary active sulfate transmembrane transporter activity
IC776_RS01115	COG0606	chelatase, subunit chli
IC776_RS01125	COG0347	Belongs to the P(II) protein family
IC776_RS01130	COG0004	ammonium transporteR
IC776_RS01140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC776_RS01140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC776_RS01175	COG0795	lipopolysaccharide-transporting ATPase activity
IC776_RS01180	COG0795	lipopolysaccharide-transporting ATPase activity
IC776_RS01185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IC776_RS01190	COG0793	Belongs to the peptidase S41A family
IC776_RS01205	COG2197	response regulator
IC776_RS01215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IC776_RS01225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC776_RS01230	COG4974	Belongs to the 'phage' integrase family
IC776_RS01255	COG0772	Belongs to the SEDS family
IC776_RS01260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC776_RS01265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IC776_RS01275	COG0494	nUDIX hydrolase
IC776_RS01295	COG0697	spore germination
IC776_RS01300	COG1538	Outer membrane efflux protein
IC776_RS01320	COG3275	phosphorelay sensor kinase activity
IC776_RS01330	COG0181	hydroxymethylbilane synthase activity
IC776_RS01375	COG1716	ATPase activity
IC776_RS01380	COG0546	phosphoglycolate phosphatase activity
IC776_RS01475	COG0596	Alpha beta hydrolase
IC776_RS01480	COG2056	Na+-H+ antiporter family
IC776_RS01495	COG0326	Molecular chaperone. Has ATPase activity
IC776_RS01510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IC776_RS01585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IC776_RS01600	COG1289	transmembrane transporter activity
IC776_RS01615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IC776_RS01625	COG0497	DNA recombination
IC776_RS01640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC776_RS01650	COG0237	dephospho-CoA kinase activity
IC776_RS01700	COG0195	Participates in both transcription termination and antitermination
IC776_RS01710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IC776_RS01715	COG1320	monovalent cation:proton antiporter activity
IC776_RS01720	COG2212	antiporter activity
IC776_RS01725	COG1863	multisubunit Na H antiporter MnhE subunit
IC776_RS01730	COG0651	ATP synthesis coupled electron transport
IC776_RS01735	COG1006	Multisubunit Na H antiporter MnhC subunit
IC776_RS01740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IC776_RS01740	COG2111	Na H antiporter
IC776_RS01755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IC776_RS01765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC776_RS01780	COG2226	methyltransferase
IC776_RS01805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IC776_RS01810	COG1074	ATP-dependent DNA helicase activity
IC776_RS01815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IC776_RS01820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IC776_RS01830	COG1185	polyribonucleotide nucleotidyltransferase activity
IC776_RS01835	COG0598	Magnesium transport protein CorA
IC776_RS01840	COG0789	Transcriptional regulator
IC776_RS01845	COG0484	heat shock protein binding
IC776_RS01855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IC776_RS01860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC776_RS01860	COG0475	glutathione-regulated potassium exporter activity
IC776_RS01865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IC776_RS01890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC776_RS01900	COG4535	Mg2 and Co2 transporter CorC
IC776_RS01915	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IC776_RS01915	COG0644	oxidoreductase
IC776_RS01925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IC776_RS01940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC776_RS01945	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IC776_RS01955	COG0493	'glutamate synthase
IC776_RS01955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC776_RS01985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IC776_RS02000	COG0534	Mate efflux family protein
IC776_RS02010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IC776_RS02015	COG4221	oxidoreductase activity
IC776_RS02020	COG0583	DNA-binding transcription factor activity
IC776_RS02035	COG0318	PFAM AMP-dependent synthetase and ligase
IC776_RS02040	COG1530	ribonuclease E activity
IC776_RS02055	COG2378	regulation of single-species biofilm formation
IC776_RS02060	COG0625	glutathione transferase activity
IC776_RS02070	COG0583	DNA-binding transcription factor activity
IC776_RS02115	COG0583	DNA-binding transcription factor activity
IC776_RS02140	COG0473	3-isopropylmalate dehydrogenase activity
IC776_RS02195	COG1301	dicarboxylic acid transport
IC776_RS02205	COG1560	Kdo2-lipid A biosynthetic process
IC776_RS02210	COG1280	lysine exporter protein (LysE YggA)
IC776_RS02220	COG0488	(ABC) transporter
IC776_RS02225	COG2900	Belongs to the SlyX family
IC776_RS02235	COG1733	regulation of RNA biosynthetic process
IC776_RS02260	COG0210	DNA helicase
IC776_RS02265	COG0724	RNA recognition motif
IC776_RS02285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC776_RS02285	COG4651	solute:proton antiporter activity
IC776_RS02310	COG0788	formyltetrahydrofolate deformylase activity
IC776_RS02405	COG2813	Specifically methylates the guanine in position
IC776_RS02405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC776_RS02415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IC776_RS02425	COG4774	siderophore transport
IC776_RS02435	COG0740	serine-type endopeptidase activity
IC776_RS02455	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IC776_RS02455	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IC776_RS02460	COG0280	phosphate acetyltransferase
IC776_RS02460	COG0857	belongs to the CobB CobQ family
IC776_RS02465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IC776_RS02475	COG0800	Aldolase
IC776_RS02485	COG3265	gluconokinase activity
IC776_RS02490	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS02500	COG2267	carboxylic ester hydrolase activity
IC776_RS02515	COG0793	Belongs to the peptidase S41A family
IC776_RS02550	COG1426	Protein conserved in bacteria
IC776_RS02590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IC776_RS02600	COG1162	GTPase activity
IC776_RS02605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IC776_RS02620	COG1538	Outer membrane efflux protein
IC776_RS02625	COG1136	(ABC) transporter
IC776_RS02625	COG0577	efflux transmembrane transporter activity
IC776_RS02630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS02655	COG0028	Belongs to the TPP enzyme family
IC776_RS02660	COG0440	acetolactate synthase activity
IC776_RS02665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IC776_RS02690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IC776_RS02705	COG0084	hydrolase, TatD family'
IC776_RS02715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IC776_RS02725	COG0583	DNA-binding transcription factor activity
IC776_RS02735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC776_RS02755	COG0629	single-stranded DNA binding
IC776_RS02790	COG3646	Phage regulatory protein
IC776_RS02960	COG4695	Portal protein
IC776_RS02965	COG2814	Major facilitator Superfamily
IC776_RS02975	COG0697	spore germination
IC776_RS03015	COG3622	Belongs to the hyi family
IC776_RS03020	COG2084	Dehydrogenase
IC776_RS03025	COG1024	Enoyl-CoA hydratase
IC776_RS03030	COG5002	protein histidine kinase activity
IC776_RS03030	COG0784	Response regulator, receiver
IC776_RS03030	COG2205	protein histidine kinase activity
IC776_RS03050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC776_RS03060	COG3956	TIGRFAM MazG family protein
IC776_RS03065	COG1555	photosystem II stabilization
IC776_RS03070	COG0617	tRNA 3'-terminal CCA addition
IC776_RS03075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IC776_RS03100	COG3028	Belongs to the UPF0307 family
IC776_RS03105	COG0318	PFAM AMP-dependent synthetase and ligase
IC776_RS03120	COG0625	glutathione transferase activity
IC776_RS03125	COG1238	metal cluster binding
IC776_RS03135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IC776_RS03165	COG0072	phenylalanine-tRNA ligase activity
IC776_RS03195	COG0248	Ppx GppA phosphatase
IC776_RS03205	COG0037	tRNA processing
IC776_RS03245	COG1764	response to oxidative stress
IC776_RS03250	COG1846	Transcriptional regulator
IC776_RS03260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC776_RS03320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IC776_RS03325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IC776_RS03330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IC776_RS03390	COG1214	PFAM Peptidase M22, glycoprotease
IC776_RS03405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IC776_RS03415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IC776_RS03420	COG0561	phosphatase activity
IC776_RS03430	COG2132	Multicopper oxidase
IC776_RS03450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IC776_RS03455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IC776_RS03460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IC776_RS03490	COG1063	alcohol dehydrogenase
IC776_RS03495	COG0583	DNA-binding transcription factor activity
IC776_RS03500	COG1960	acyl-CoA dehydrogenase activity
IC776_RS03505	COG2814	Major facilitator Superfamily
IC776_RS03510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC776_RS03520	COG1309	transcriptional regulator
IC776_RS03535	COG1053	succinate dehydrogenase
IC776_RS03540	COG0583	DNA-binding transcription factor activity
IC776_RS03555	COG0583	DNA-binding transcription factor activity
IC776_RS03565	COG0583	DNA-binding transcription factor activity
IC776_RS03580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC776_RS03625	COG0583	DNA-binding transcription factor activity
IC776_RS03630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IC776_RS03660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IC776_RS03680	COG0745	RESPONSE REGULATOR receiver
IC776_RS03695	COG3706	GGDEF domain
IC776_RS03720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IC776_RS03735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC776_RS03750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IC776_RS03755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC776_RS03780	COG0583	DNA-binding transcription factor activity
IC776_RS03800	COG0668	transmembrane transport
IC776_RS03810	COG2081	HI0933 family
IC776_RS03815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IC776_RS03850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC776_RS03850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC776_RS03860	COG0489	protein tyrosine kinase activity
IC776_RS03865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IC776_RS03910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC776_RS03920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IC776_RS03935	COG0730	response to heat
IC776_RS03945	COG1196	nuclear chromosome segregation
IC776_RS03965	COG2223	nitrite transmembrane transporter activity
IC776_RS03970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IC776_RS03975	COG1877	trehalose-phosphatase activity
IC776_RS03980	COG2226	methyltransferase
IC776_RS03980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC776_RS03980	COG0596	Alpha beta hydrolase
IC776_RS03995	COG4106	trans-aconitate 2-methyltransferase activity
IC776_RS04010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IC776_RS04015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IC776_RS04020	COG0009	L-threonylcarbamoyladenylate synthase
IC776_RS04025	COG3101	peptidyl-lysine hydroxylation
IC776_RS04030	COG1399	metal-binding, possibly nucleic acid-binding protein
IC776_RS04055	COG1652	LysM domain
IC776_RS04060	COG0352	thiamine-phosphate diphosphorylase activity
IC776_RS04060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IC776_RS04060	COG0351	phosphomethylpyrimidine kinase
IC776_RS04070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IC776_RS04100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC776_RS04130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IC776_RS04145	COG0358	DNA primase activity
IC776_RS04180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC776_RS04200	COG0583	DNA-binding transcription factor activity
IC776_RS04205	COG0473	3-isopropylmalate dehydrogenase activity
IC776_RS04215	COG0657	acetylesterase activity
IC776_RS04220	COG4638	Rieske (2fe-2S)
IC776_RS04225	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS04245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC776_RS04245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IC776_RS04255	COG1981	membrane
IC776_RS04270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IC776_RS04280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IC776_RS04300	COG0456	acetyltransferase
IC776_RS04310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IC776_RS04315	COG0492	ferredoxin-NADP+ reductase activity
IC776_RS04320	COG1674	ftsk spoiiie
IC776_RS04325	COG1280	lysine exporter protein (LysE YggA)
IC776_RS04340	COG2894	cell division
IC776_RS04355	COG0204	Acyl-transferase
IC776_RS04360	COG2885	chlorophyll binding
IC776_RS04365	COG0210	DNA helicase
IC776_RS04375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IC776_RS04390	COG0121	glutamine amidotransferase
IC776_RS04405	COG2914	Belongs to the UPF0125 (RnfH) family
IC776_RS04410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IC776_RS04415	COG0735	belongs to the Fur family
IC776_RS04435	COG1968	undecaprenyl-diphosphatase activity
IC776_RS04445	COG0420	3'-5' exonuclease activity
IC776_RS04465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IC776_RS04480	COG2050	protein possibly involved in aromatic compounds catabolism
IC776_RS04490	COG2814	Major facilitator Superfamily
IC776_RS04495	COG0405	Gamma-glutamyltransferase
IC776_RS04505	COG1401	restriction endodeoxyribonuclease activity
IC776_RS04545	COG1404	Belongs to the peptidase S8 family
IC776_RS04555	COG2814	Major facilitator Superfamily
IC776_RS04560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC776_RS04570	COG1595	DNA-templated transcription, initiation
IC776_RS04625	COG0531	amino acid
IC776_RS04630	COG2040	homocysteine
IC776_RS04655	COG1309	transcriptional regulator
IC776_RS04660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC776_RS04665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC776_RS04675	COG1607	acyl-coa hydrolase
IC776_RS04685	COG0523	cobalamin synthesis protein
IC776_RS04695	COG4681	YaeQ
IC776_RS04705	COG0726	polysaccharide deacetylase
IC776_RS04705	COG1649	PFAM Uncharacterised BCR, COG1649
IC776_RS04710	COG1215	transferase activity, transferring glycosyl groups
IC776_RS04720	COG1024	Enoyl-CoA hydratase
IC776_RS04750	COG1414	Transcriptional regulator
IC776_RS04785	COG2271	Major facilitator Superfamily
IC776_RS04795	COG2267	carboxylic ester hydrolase activity
IC776_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS04815	COG0028	Belongs to the TPP enzyme family
IC776_RS04825	COG0477	Major facilitator Superfamily
IC776_RS04830	COG0242	peptide deformylase activity
IC776_RS04835	COG2066	Belongs to the glutaminase family
IC776_RS04840	COG2207	Transcriptional regulator
IC776_RS04845	COG2223	nitrite transmembrane transporter activity
IC776_RS04875	COG0306	phosphate transporter
IC776_RS04895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC776_RS04940	COG4181	ATPase activity
IC776_RS04945	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IC776_RS04970	COG0583	DNA-binding transcription factor activity
IC776_RS04980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC776_RS04985	COG1773	rubredoxin
IC776_RS05035	COG2851	Citrate transporter
IC776_RS05040	COG1253	flavin adenine dinucleotide binding
IC776_RS05080	COG0804	urea catabolic process
IC776_RS05090	COG0830	nickel cation binding
IC776_RS05110	COG0742	ribosomal rna small subunit methyltransferase
IC776_RS05115	COG0768	penicillin binding
IC776_RS05140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IC776_RS05145	COG2878	Part of a membrane complex involved in electron transport
IC776_RS05150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IC776_RS05160	COG3384	dioxygenase
IC776_RS05195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IC776_RS05230	COG0006	proline dipeptidase activity
IC776_RS05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC776_RS05240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC776_RS05260	COG1279	arginine transmembrane transporter activity
IC776_RS05265	COG0583	DNA-binding transcription factor activity
IC776_RS05310	COG1388	LysM domain
IC776_RS05310	COG0741	lytic transglycosylase activity
IC776_RS05315	COG4166	transmembrane transport
IC776_RS05320	COG4174	ABC transporter (Permease)
IC776_RS05325	COG4239	(ABC) transporter, permease
IC776_RS05330	COG4172	Belongs to the ABC transporter superfamily
IC776_RS05365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IC776_RS05375	COG5001	Diguanylate cyclase
IC776_RS05375	COG4251	negative regulation of phosphorylation
IC776_RS05375	COG2203	Gaf domain
IC776_RS05375	COG3706	GGDEF domain
IC776_RS05385	COG1902	pentaerythritol trinitrate reductase activity
IC776_RS05385	COG0446	pyridine nucleotide-disulphide oxidoreductase
IC776_RS05405	COG0251	oxidation-reduction process
IC776_RS05415	COG0583	DNA-binding transcription factor activity
IC776_RS05500	COG0747	negative chemotaxis
IC776_RS05505	COG0601	transmembrane transport
IC776_RS05510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IC776_RS05515	COG0444	Belongs to the ABC transporter superfamily
IC776_RS05520	COG4608	Belongs to the ABC transporter superfamily
IC776_RS05535	COG1280	lysine exporter protein (LysE YggA)
IC776_RS05540	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC776_RS05555	COG1846	Transcriptional regulator
IC776_RS05570	COG3209	COG3209 Rhs family protein
IC776_RS05625	COG1113	amino acid transport
IC776_RS05635	COG0531	amino acid
IC776_RS05655	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS05675	COG1113	amino acid transport
IC776_RS05710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC776_RS05735	COG4796	Type ii and iii secretion system protein
IC776_RS05740	COG2165	general secretion pathway protein
IC776_RS05770	COG0697	spore germination
IC776_RS05795	COG1960	acyl-CoA dehydrogenase activity
IC776_RS05805	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS05810	COG1024	Enoyl-CoA hydratase
IC776_RS05815	COG2814	Major facilitator Superfamily
IC776_RS05830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC776_RS05845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC776_RS05865	COG1944	ATP diphosphatase activity
IC776_RS05895	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IC776_RS05900	COG2072	flavoprotein involved in K transport
IC776_RS05915	COG1309	transcriptional regulator
IC776_RS05920	COG1741	Belongs to the pirin family
IC776_RS05935	COG2072	flavoprotein involved in K transport
IC776_RS05945	COG2252	PERMEase
IC776_RS05950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IC776_RS05955	COG3038	cytochrome b561
IC776_RS05965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IC776_RS05975	COG0527	aspartate kinase activity
IC776_RS05985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IC776_RS06000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IC776_RS06015	COG0667	Aldo Keto reductase
IC776_RS06025	COG1765	OsmC-like protein
IC776_RS06040	COG0542	response to heat
IC776_RS06085	COG0625	glutathione transferase activity
IC776_RS06090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IC776_RS06110	COG3634	alkyl hydroperoxide reductase activity
IC776_RS06120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IC776_RS06130	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC776_RS06145	COG1643	Atp-dependent helicase
IC776_RS06160	COG2814	Major facilitator Superfamily
IC776_RS06165	COG3135	benzoate transporter
IC776_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS06175	COG0633	Ferredoxin
IC776_RS06175	COG0543	2 iron, 2 sulfur cluster binding
IC776_RS06180	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IC776_RS06185	COG4638	Rieske (2fe-2S)
IC776_RS06195	COG0583	DNA-binding transcription factor activity
IC776_RS06205	COG2871	sodium ion transport
IC776_RS06290	COG1570	exodeoxyribonuclease VII activity
IC776_RS06320	COG1280	lysine exporter protein (LysE YggA)
IC776_RS06325	COG1278	Cold shock
IC776_RS06355	COG2814	Major facilitator Superfamily
IC776_RS06365	COG0667	Aldo Keto reductase
IC776_RS06410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IC776_RS06410	COG0517	IMP dehydrogenase activity
IC776_RS06415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IC776_RS06425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IC776_RS06430	COG1137	ATPase activity
IC776_RS06435	COG1538	Outer membrane efflux protein
IC776_RS06465	COG4122	O-methyltransferase activity
IC776_RS06475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IC776_RS06500	COG2205	protein histidine kinase activity
IC776_RS06510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC776_RS06580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IC776_RS06590	COG1469	GTP cyclohydrolase I activity
IC776_RS06600	COG1294	oxidase, subunit
IC776_RS06605	COG1271	oxidase subunit
IC776_RS06625	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
IC776_RS06645	COG2814	Major facilitator Superfamily
IC776_RS06665	COG4774	siderophore transport
IC776_RS06670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC776_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS06690	COG1522	sequence-specific DNA binding
IC776_RS06695	COG0626	cystathionine gamma-synthase activity
IC776_RS06705	COG1278	Cold shock
IC776_RS06710	COG1309	transcriptional regulator
IC776_RS06755	COG1011	Hydrolase
IC776_RS06820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC776_RS06825	COG3713	MltA-interacting MipA family protein
IC776_RS06840	COG2076	Multidrug Resistance protein
IC776_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS06875	COG3220	belongs to the UPF0276 family
IC776_RS06885	COG1595	DNA-templated transcription, initiation
IC776_RS06895	COG0583	DNA-binding transcription factor activity
IC776_RS06900	COG1914	H( )-stimulated, divalent metal cation uptake system
IC776_RS06920	COG4770	biotin carboxylase activity
IC776_RS06925	COG0038	chloride channel
IC776_RS06965	COG0439	Biotin carboxylase
IC776_RS06970	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC776_RS06975	COG1733	regulation of RNA biosynthetic process
IC776_RS06990	COG0864	Transcriptional regulator
IC776_RS07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC776_RS07005	COG1116	anion transmembrane transporter activity
IC776_RS07020	COG0477	Major facilitator Superfamily
IC776_RS07125	COG0590	tRNA wobble adenosine to inosine editing
IC776_RS07130	COG2807	transmembrane transport
IC776_RS07145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC776_RS07150	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IC776_RS07160	COG0789	Transcriptional regulator
IC776_RS07175	COG1760	l-serine dehydratase
IC776_RS07180	COG2030	dehydratase
IC776_RS07180	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS07185	COG3396	Phenylacetate-CoA oxygenase
IC776_RS07190	COG3460	Phenylacetate-CoA oxygenase
IC776_RS07195	COG3396	Phenylacetate-CoA oxygenase
IC776_RS07200	COG2151	metal-sulfur cluster biosynthetic enzyme
IC776_RS07205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC776_RS07210	COG1024	Enoyl-CoA hydratase
IC776_RS07215	COG1024	Enoyl-CoA hydratase
IC776_RS07220	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC776_RS07225	COG0183	Belongs to the thiolase family
IC776_RS07230	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IC776_RS07235	COG3327	negative regulation of DNA-templated transcription, initiation
IC776_RS07245	COG2050	protein possibly involved in aromatic compounds catabolism
IC776_RS07260	COG1309	transcriptional regulator
IC776_RS07265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC776_RS07280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IC776_RS07285	COG0531	amino acid
IC776_RS07290	COG0753	catalase activity
IC776_RS07295	COG3038	cytochrome b561
IC776_RS07300	COG0583	DNA-binding transcription factor activity
IC776_RS07310	COG1414	Transcriptional regulator
IC776_RS07315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC776_RS07330	COG1840	ABC-type Fe3 transport system, periplasmic component
IC776_RS07335	COG3842	ATPase activity
IC776_RS07350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IC776_RS07355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IC776_RS07370	COG0583	DNA-binding transcription factor activity
IC776_RS07380	COG4770	biotin carboxylase activity
IC776_RS07385	COG1024	Enoyl-CoA hydratase
IC776_RS07390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IC776_RS07395	COG1960	acyl-CoA dehydrogenase activity
IC776_RS07400	COG1309	transcriptional regulator
IC776_RS07405	COG0318	PFAM AMP-dependent synthetase and ligase
IC776_RS07425	COG0583	DNA-binding transcription factor activity
IC776_RS07475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IC776_RS07495	COG0784	Response regulator, receiver
IC776_RS07495	COG2205	protein histidine kinase activity
IC776_RS07535	COG0765	amino acid transport
IC776_RS07540	COG0765	amino acid transport
IC776_RS07550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC776_RS07555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC776_RS07565	COG1280	lysine exporter protein (LysE YggA)
IC776_RS07570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IC776_RS07575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC776_RS07580	COG1045	serine acetyltransferase
IC776_RS07595	COG0583	DNA-binding transcription factor activity
IC776_RS07600	COG0625	glutathione transferase activity
IC776_RS07605	COG0625	glutathione transferase activity
IC776_RS07610	COG0583	DNA-binding transcription factor activity
IC776_RS07620	COG1346	cytolysis
IC776_RS07640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC776_RS07650	COG1294	oxidase, subunit
IC776_RS07655	COG1271	oxidase subunit
IC776_RS07675	COG0477	Major facilitator Superfamily
IC776_RS07685	COG4521	taurine ABC transporter
IC776_RS07690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IC776_RS07695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC776_RS07700	COG2175	clavaminate synthase activity
IC776_RS07710	COG1953	Uracil, thiamine, allantoin
IC776_RS07720	COG0583	DNA-binding transcription factor activity
IC776_RS07730	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IC776_RS07745	COG0640	Transcriptional regulator
IC776_RS07750	COG0798	PFAM Bile acid sodium symporter
IC776_RS07755	COG0431	NADPH-dependent FMN reductase
IC776_RS07760	COG0583	DNA-binding transcription factor activity
IC776_RS07775	COG3634	alkyl hydroperoxide reductase activity
IC776_RS07810	COG1301	dicarboxylic acid transport
IC776_RS07815	COG0436	Aminotransferase
IC776_RS07825	COG0386	Belongs to the glutathione peroxidase family
IC776_RS07865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IC776_RS07890	COG0012	GTP binding
IC776_RS07895	COG2011	ABC-type metal ion transport system permease component
IC776_RS07900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IC776_RS07905	COG1464	Belongs to the NlpA lipoprotein family
IC776_RS07935	COG0765	amino acid transport
IC776_RS07940	COG0765	amino acid transport
IC776_RS07945	COG1126	abc transporter atp-binding protein
IC776_RS07955	COG1522	sequence-specific DNA binding
IC776_RS07980	COG2197	response regulator
IC776_RS08000	COG0583	DNA-binding transcription factor activity
IC776_RS08010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IC776_RS08020	COG0697	spore germination
IC776_RS08040	COG3121	Chaperone
IC776_RS08045	COG3539	Fimbrial protein
IC776_RS08070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IC776_RS08070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IC776_RS08110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IC776_RS08120	COG2353	YceI-like domain
IC776_RS08130	COG3698	Phosphodiester glycosidase
IC776_RS08145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IC776_RS08150	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IC776_RS08150	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IC776_RS08150	COG0506	proline dehydrogenase activity
IC776_RS08160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC776_RS08165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IC776_RS08185	COG1132	(ABC) transporter
IC776_RS08190	COG3122	Protein conserved in bacteria
IC776_RS08195	COG3619	membrane
IC776_RS08205	COG0640	Transcriptional regulator
IC776_RS08215	COG2850	peptidyl-arginine hydroxylation
IC776_RS08220	COG0424	maF-like protein
IC776_RS08260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IC776_RS08270	COG1192	Involved in chromosome partitioning
IC776_RS08275	COG1475	DNA binding
IC776_RS08280	COG0811	peptide transport
IC776_RS08290	COG1132	(ABC) transporter
IC776_RS08295	COG1663	tetraacyldisaccharide 4'-kinase activity
IC776_RS08315	COG0084	hydrolase, TatD family'
IC776_RS08380	COG0776	regulation of translation
IC776_RS08395	COG2431	L-lysine efflux transmembrane transporter activity
IC776_RS08410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IC776_RS08415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IC776_RS08440	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IC776_RS08470	COG0601	transmembrane transport
IC776_RS08475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IC776_RS08480	COG4172	Belongs to the ABC transporter superfamily
IC776_RS08510	COG0702	epimerase
IC776_RS08515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IC776_RS08535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IC776_RS08565	COG0316	Belongs to the HesB IscA family
IC776_RS08570	COG0822	iron-sulfur transferase activity
IC776_RS08595	COG0776	regulation of translation
IC776_RS08600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IC776_RS08605	COG2207	Transcriptional regulator
IC776_RS08610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC776_RS08615	COG1960	acyl-CoA dehydrogenase activity
IC776_RS08620	COG1960	acyl-CoA dehydrogenase activity
IC776_RS08635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IC776_RS08640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IC776_RS08655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IC776_RS08660	COG0406	alpha-ribazole phosphatase activity
IC776_RS08675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IC776_RS08680	COG0730	response to heat
IC776_RS08700	COG4773	Receptor
IC776_RS08705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC776_RS08720	COG1131	(ABC) transporter
IC776_RS08725	COG0842	Transport permease protein
IC776_RS08730	COG0842	Transport permease protein
IC776_RS08780	COG2226	methyltransferase
IC776_RS08805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IC776_RS08840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC776_RS08850	COG0133	tryptophan synthase activity
IC776_RS08865	COG3706	GGDEF domain
IC776_RS08880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IC776_RS08885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IC776_RS08890	COG0022	dehydrogenase e1 component
IC776_RS08895	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC776_RS08900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC776_RS08910	COG1063	alcohol dehydrogenase
IC776_RS08915	COG3781	membrane
IC776_RS08925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC776_RS08925	COG3453	Protein conserved in bacteria
IC776_RS08935	COG0730	response to heat
IC776_RS08950	COG2207	Transcriptional regulator
IC776_RS08950	COG3708	Transcriptional regulator
IC776_RS08960	COG0477	Major facilitator Superfamily
IC776_RS08970	COG1027	Aspartate ammonia-lyase
IC776_RS08990	COG0659	secondary active sulfate transmembrane transporter activity
IC776_RS08995	COG0589	response to stress
IC776_RS09030	COG0583	DNA-binding transcription factor activity
IC776_RS09035	COG0583	DNA-binding transcription factor activity
IC776_RS09040	COG0183	Belongs to the thiolase family
IC776_RS09045	COG2031	fatty acid transporter
IC776_RS09060	COG0583	DNA-binding transcription factor activity
IC776_RS09085	COG2814	Major facilitator Superfamily
IC776_RS09115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC776_RS09120	COG2610	gluconate transmembrane transporter activity
IC776_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS09130	COG2207	Transcriptional regulator
IC776_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS09160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC776_RS09175	COG0543	2 iron, 2 sulfur cluster binding
IC776_RS09175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC776_RS09180	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IC776_RS09185	COG4638	Rieske (2fe-2S)
IC776_RS09195	COG0725	ABC transporter, periplasmic molybdate-binding protein
IC776_RS09200	COG4149	molybdate abc transporter
IC776_RS09205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IC776_RS09230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC776_RS09235	COG3251	PFAM MbtH domain protein
IC776_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS09250	COG1169	isochorismate synthase
IC776_RS09255	COG1021	2,3-dihydroxybenzoate-AMP ligase
IC776_RS09260	COG3433	isochorismatase activity
IC776_RS09260	COG1535	isochorismatase
IC776_RS09265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC776_RS09270	COG4771	TonB-dependent receptor
IC776_RS09330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC776_RS09335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS09340	COG0745	RESPONSE REGULATOR receiver
IC776_RS09345	COG2205	protein histidine kinase activity
IC776_RS09355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC776_RS09360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IC776_RS09370	COG0753	catalase activity
IC776_RS09380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IC776_RS09405	COG3539	Fimbrial protein
IC776_RS09415	COG2801	Transposase and inactivated derivatives
IC776_RS09505	COG1073	alpha beta
IC776_RS09595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC776_RS09615	COG1120	ATPase activity
IC776_RS09620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IC776_RS09655	COG1566	PFAM secretion protein HlyD family protein
IC776_RS09665	COG2271	Major facilitator Superfamily
IC776_RS09680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC776_RS09710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IC776_RS09715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IC776_RS09740	COG0583	DNA-binding transcription factor activity
IC776_RS09745	COG2188	Transcriptional regulator
IC776_RS09845	COG4689	acetoacetate decarboxylase
IC776_RS09850	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS09860	COG4774	siderophore transport
IC776_RS09875	COG1309	transcriptional regulator
IC776_RS09910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IC776_RS09940	COG0583	DNA-binding transcription factor activity
IC776_RS09945	COG4948	Mandelate Racemase Muconate Lactonizing
IC776_RS09950	COG4829	muconolactone delta-isomerase
IC776_RS09960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IC776_RS09965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC776_RS09970	COG0183	Belongs to the thiolase family
IC776_RS09975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC776_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS09990	COG3733	amine oxidase
IC776_RS10000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC776_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS10020	COG4638	Rieske (2fe-2S)
IC776_RS10040	COG0154	amidase activity
IC776_RS10050	COG2814	Major facilitator Superfamily
IC776_RS10075	COG1960	acyl-CoA dehydrogenase activity
IC776_RS10080	COG0583	DNA-binding transcription factor activity
IC776_RS10085	COG1414	Transcriptional regulator
IC776_RS10100	COG2391	methyltransferase activity
IC776_RS10110	COG4993	Dehydrogenase
IC776_RS10115	COG3659	wide pore channel activity
IC776_RS10120	COG3420	alginic acid biosynthetic process
IC776_RS10125	COG0710	3-dehydroquinate dehydratase activity
IC776_RS10130	COG3485	protocatechuate 3,4-dioxygenase
IC776_RS10135	COG3485	protocatechuate 3,4-dioxygenase
IC776_RS10140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IC776_RS10145	COG2271	Major facilitator Superfamily
IC776_RS10150	COG0596	Alpha beta hydrolase
IC776_RS10155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IC776_RS10160	COG0183	Belongs to the thiolase family
IC776_RS10165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC776_RS10170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IC776_RS10180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IC776_RS10190	COG2323	membrane
IC776_RS10195	COG0148	phosphopyruvate hydratase activity
IC776_RS10235	COG0446	pyridine nucleotide-disulphide oxidoreductase
IC776_RS10235	COG1902	pentaerythritol trinitrate reductase activity
IC776_RS10260	COG0542	response to heat
IC776_RS10265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IC776_RS10295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IC776_RS10300	COG0569	domain protein
IC776_RS10305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IC776_RS10320	COG4774	siderophore transport
IC776_RS10325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IC776_RS10335	COG1585	Membrane protein implicated in regulation of membrane protease activity
IC776_RS10350	COG1294	oxidase, subunit
IC776_RS10355	COG4890	Cyd operon protein YbgT
IC776_RS10370	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IC776_RS10380	COG0552	protein localization to endoplasmic reticulum
IC776_RS10405	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IC776_RS10410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC776_RS10415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IC776_RS10425	COG0583	DNA-binding transcription factor activity
IC776_RS10430	COG0024	Methionine aminopeptidase
IC776_RS10460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IC776_RS10460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IC776_RS10465	COG1105	Belongs to the carbohydrate kinase PfkB family
IC776_RS10470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IC776_RS10470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IC776_RS10470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IC776_RS10485	COG3300	MHYT domain
IC776_RS10485	COG5001	Diguanylate cyclase
IC776_RS10500	COG0659	secondary active sulfate transmembrane transporter activity
IC776_RS10515	COG1113	amino acid transport
IC776_RS10525	COG1522	sequence-specific DNA binding
IC776_RS10540	COG1011	Hydrolase
IC776_RS10545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IC776_RS10555	COG2137	regulation of response to DNA damage stimulus
IC776_RS10570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC776_RS10605	COG0575	Belongs to the CDS family
IC776_RS10610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IC776_RS10630	COG3852	Histidine kinase
IC776_RS10635	COG2204	response regulator
IC776_RS10690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IC776_RS10695	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IC776_RS10715	COG0697	spore germination
IC776_RS10720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC776_RS10730	COG0303	'Molybdopterin
IC776_RS10735	COG0521	Mo-molybdopterin cofactor biosynthetic process
IC776_RS10735	COG0315	cyclic pyranopterin monophosphate synthase activity
IC776_RS10750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IC776_RS10765	COG0243	molybdopterin cofactor binding
IC776_RS10770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC776_RS10775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC776_RS10785	COG0745	RESPONSE REGULATOR receiver
IC776_RS10790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC776_RS10790	COG1116	anion transmembrane transporter activity
IC776_RS10810	COG0511	ligase activity, forming carbon-carbon bonds
IC776_RS10825	COG2814	Major facilitator Superfamily
IC776_RS10870	COG0069	glutamate synthase activity
IC776_RS10900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IC776_RS10925	COG1454	alcohol dehydrogenase
IC776_RS10930	COG0824	Thioesterase
IC776_RS10945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IC776_RS10975	COG2030	dehydratase
IC776_RS10985	COG0183	Belongs to the thiolase family
IC776_RS10995	COG0583	DNA-binding transcription factor activity
IC776_RS11000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IC776_RS11010	COG1522	sequence-specific DNA binding
IC776_RS11015	COG3135	benzoate transporter
IC776_RS11040	COG0589	response to stress
IC776_RS11045	COG0488	(ABC) transporter
IC776_RS11090	COG0668	transmembrane transport
IC776_RS11100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC776_RS11105	COG2423	ornithine cyclodeaminase activity
IC776_RS11110	COG4264	IucA IucC family
IC776_RS11120	COG4264	IucA IucC family
IC776_RS11160	COG1605	Chorismate mutase
IC776_RS11175	COG0625	glutathione transferase activity
IC776_RS11205	COG0308	aminopeptidase N
IC776_RS11225	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IC776_RS11235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IC776_RS11240	COG1454	alcohol dehydrogenase
IC776_RS11260	COG0531	amino acid
IC776_RS11265	COG4303	Ethanolamine ammonia lyase large subunit
IC776_RS11270	COG4302	ethanolamine ammonia-lyase activity
IC776_RS11275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC776_RS11275	COG0519	Catalyzes the synthesis of GMP from XMP
IC776_RS11280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC776_RS11305	COG0697	spore germination
IC776_RS11310	COG1923	regulation of RNA biosynthetic process
IC776_RS11320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IC776_RS11325	COG0802	atpase or kinase
IC776_RS11345	COG1187	pseudouridine synthase activity
IC776_RS11360	COG0583	DNA-binding transcription factor activity
IC776_RS11370	COG2814	Major facilitator Superfamily
IC776_RS11375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC776_RS11405	COG0729	surface antigen
IC776_RS11425	COG0174	glutamine synthetase
IC776_RS11430	COG0745	RESPONSE REGULATOR receiver
IC776_RS11435	COG2205	protein histidine kinase activity
IC776_RS11440	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IC776_RS11445	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IC776_RS11450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IC776_RS11460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IC776_RS11475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC776_RS11480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC776_RS11485	COG1960	acyl-CoA dehydrogenase activity
IC776_RS11500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC776_RS11505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC776_RS11510	COG2890	protein-(glutamine-N5) methyltransferase activity
IC776_RS11530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC776_RS11540	COG3658	cytochrome
IC776_RS11545	COG1215	transferase activity, transferring glycosyl groups
IC776_RS11550	COG0726	polysaccharide deacetylase
IC776_RS11550	COG1649	PFAM Uncharacterised BCR, COG1649
IC776_RS11580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IC776_RS11590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IC776_RS11615	COG0305	Participates in initiation and elongation during chromosome replication
IC776_RS11620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IC776_RS11640	COG2308	Evidence 4 Homologs of previously reported genes of
IC776_RS11670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IC776_RS11675	COG0138	bifunctional purine biosynthesis protein purh
IC776_RS11680	COG0151	Belongs to the GarS family
IC776_RS11685	COG1464	Belongs to the NlpA lipoprotein family
IC776_RS11690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IC776_RS11695	COG2011	ABC-type metal ion transport system permease component
IC776_RS11710	COG1301	dicarboxylic acid transport
IC776_RS11750	COG0745	RESPONSE REGULATOR receiver
IC776_RS11755	COG0642	Histidine kinase
IC776_RS11760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IC776_RS11770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IC776_RS11795	COG5002	protein histidine kinase activity
IC776_RS11810	COG2351	hydroxyisourate hydrolase activity
IC776_RS11820	COG3008	intermembrane lipid transfer
IC776_RS11820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IC776_RS11825	COG2995	paraquat-inducible protein a
IC776_RS11850	COG2985	domain, Protein
IC776_RS11865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IC776_RS11865	COG2169	Transcriptional regulator
IC776_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS11960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC776_RS11960	COG0475	glutathione-regulated potassium exporter activity
IC776_RS11965	COG0786	glutamate:sodium symporter activity
IC776_RS12060	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IC776_RS12155	COG3210	domain, Protein
IC776_RS12155	COG3210	domain, Protein
IC776_RS12160	COG2831	hemolysin activation secretion protein
IC776_RS12185	COG2815	serine threonine protein kinase
IC776_RS12185	COG0515	serine threonine protein kinase
IC776_RS12215	COG1610	YqeY-like protein
IC776_RS12275	COG0778	Nitroreductase
IC776_RS12285	COG0513	Belongs to the DEAD box helicase family
IC776_RS12305	COG2363	Small membrane protein
IC776_RS12335	COG4650	regulator
IC776_RS12340	COG1234	tRNA 3'-trailer cleavage
IC776_RS12345	COG1690	Belongs to the RtcB family
IC776_RS12365	COG2195	Cleaves the N-terminal amino acid of tripeptides
IC776_RS12370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC776_RS12380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IC776_RS12400	COG1960	acyl-CoA dehydrogenase activity
IC776_RS12405	COG1301	dicarboxylic acid transport
IC776_RS12410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IC776_RS12415	COG3139	Protein of unknown function (DUF1315)
IC776_RS12420	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IC776_RS12425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IC776_RS12445	COG0642	Histidine kinase
IC776_RS12460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC776_RS12470	COG1720	tRNA m6t6A37 methyltransferase activity
IC776_RS12480	COG0384	phenazine biosynthesis protein PhzF
IC776_RS12485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC776_RS12490	COG0826	peptidase U32
IC776_RS12495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC776_RS12505	COG4598	ABC transporter
IC776_RS12510	COG4160	amino acid transport
IC776_RS12515	COG4215	(ABC) transporter
IC776_RS12530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS12570	COG1131	(ABC) transporter
IC776_RS12575	COG0842	Transport permease protein
IC776_RS12590	COG0772	Belongs to the SEDS family
IC776_RS12595	COG2951	lytic endotransglycosylase activity
IC776_RS12620	COG2207	Transcriptional regulator
IC776_RS12635	COG0052	Belongs to the universal ribosomal protein uS2 family
IC776_RS12640	COG0024	Methionine aminopeptidase
IC776_RS12650	COG2223	nitrite transmembrane transporter activity
IC776_RS12660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC776_RS12665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IC776_RS12670	COG1960	acyl-CoA dehydrogenase activity
IC776_RS12685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IC776_RS12690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IC776_RS12695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IC776_RS12715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC776_RS12720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IC776_RS12725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IC776_RS12760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IC776_RS12770	COG0174	glutamine synthetase
IC776_RS12785	COG0512	Glutamine amidotransferase of anthranilate synthase
IC776_RS12790	COG0308	aminopeptidase N
IC776_RS12810	COG2840	Smr protein MutS2
IC776_RS12820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IC776_RS12830	COG0302	gtp cyclohydrolase
IC776_RS12850	COG3739	integral membrane protein
IC776_RS12865	COG1741	Belongs to the pirin family
IC776_RS12885	COG2423	ornithine cyclodeaminase activity
IC776_RS12890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IC776_RS12915	COG2814	Major facilitator Superfamily
IC776_RS12930	COG1401	restriction endodeoxyribonuclease activity
IC776_RS12940	COG2879	small protein
IC776_RS12945	COG1966	Carbon starvation protein
IC776_RS12950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IC776_RS12965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IC776_RS12990	COG1067	ATP-dependent peptidase activity
IC776_RS12995	COG0583	DNA-binding transcription factor activity
IC776_RS13020	COG1686	Belongs to the peptidase S11 family
IC776_RS13025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IC776_RS13050	COG3647	Membrane
IC776_RS13065	COG0616	signal peptide processing
IC776_RS13070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IC776_RS13080	COG0573	inorganic phosphate transmembrane transporter activity
IC776_RS13085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IC776_RS13090	COG1113	amino acid transport
IC776_RS13095	COG3961	Belongs to the TPP enzyme family
IC776_RS13100	COG1522	sequence-specific DNA binding
IC776_RS13110	COG0076	glutamate decarboxylase activity
IC776_RS13115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC776_RS13140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC776_RS13175	COG0352	thiamine-phosphate diphosphorylase activity
IC776_RS13200	COG0612	Peptidase, M16
IC776_RS13210	COG1823	symporter activity
IC776_RS13215	COG0583	DNA-binding transcription factor activity
IC776_RS13220	COG0477	Major facilitator Superfamily
IC776_RS13245	COG1187	pseudouridine synthase activity
IC776_RS13265	COG1686	Belongs to the peptidase S11 family
IC776_RS13270	COG1252	NADH dehydrogenase
IC776_RS13280	COG0415	Belongs to the DNA photolyase family
IC776_RS13295	COG1215	transferase activity, transferring glycosyl groups
IC776_RS13320	COG2070	2-Nitropropane dioxygenase
IC776_RS13375	COG0556	nucleotide-excision repair
IC776_RS13380	COG3706	GGDEF domain
IC776_RS13400	COG0436	Aminotransferase
IC776_RS13425	COG4221	oxidoreductase activity
IC776_RS13435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IC776_RS13440	COG1381	Involved in DNA repair and RecF pathway recombination
IC776_RS13450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IC776_RS13465	COG0681	Belongs to the peptidase S26 family
IC776_RS13470	COG0481	GTPase activity
IC776_RS13480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC776_RS13500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IC776_RS13505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IC776_RS13510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IC776_RS13520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IC776_RS13525	COG4208	sulfate ABC transporter
IC776_RS13530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IC776_RS13535	COG0583	DNA-binding transcription factor activity
IC776_RS13540	COG4625	pathogenesis
IC776_RS13550	COG0602	queuosine metabolic process
IC776_RS13555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IC776_RS13570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IC776_RS13585	COG1056	cytidyltransferase-related domain
IC776_RS13585	COG1051	belongs to the nudix hydrolase family
IC776_RS13590	COG1024	Enoyl-CoA hydratase
IC776_RS13605	COG2814	Major facilitator Superfamily
IC776_RS13610	COG0047	phosphoribosylformylglycinamidine synthase activity
IC776_RS13610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IC776_RS13640	COG1473	amidohydrolase
IC776_RS13645	COG0824	Thioesterase
IC776_RS13665	COG0823	Involved in the tonB-independent uptake of proteins
IC776_RS13685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC776_RS13720	COG0628	permease
IC776_RS13730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IC776_RS13735	COG0596	Alpha beta hydrolase
IC776_RS13740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IC776_RS13740	COG0616	signal peptide processing
IC776_RS13750	COG2333	competence protein COMEC
IC776_RS13750	COG0658	competence protein
IC776_RS13755	COG1136	(ABC) transporter
IC776_RS13760	COG4591	ABC-type transport system involved in lipoprotein release permease component
IC776_RS13795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS13815	COG0463	Glycosyl transferase, family 2
IC776_RS13825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IC776_RS13835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC776_RS13855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IC776_RS13860	COG1280	lysine exporter protein (LysE YggA)
IC776_RS13870	COG0019	diaminopimelate decarboxylase activity
IC776_RS13880	COG1113	amino acid transport
IC776_RS13885	COG1115	amino acid carrier protein
IC776_RS13910	COG3339	Conserved Protein
IC776_RS13915	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IC776_RS13920	COG0243	molybdopterin cofactor binding
IC776_RS13925	COG1929	Belongs to the glycerate kinase type-1 family
IC776_RS13940	COG0778	Nitroreductase
IC776_RS13945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC776_RS13950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS13975	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IC776_RS13980	COG0583	DNA-binding transcription factor activity
IC776_RS13985	COG0596	Alpha beta hydrolase
IC776_RS13990	COG0596	Alpha beta hydrolase
IC776_RS13990	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC776_RS13995	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC776_RS13995	COG0596	Alpha beta hydrolase
IC776_RS14000	COG1902	pentaerythritol trinitrate reductase activity
IC776_RS14005	COG1309	transcriptional regulator
IC776_RS14035	COG3811	Belongs to the UPF0386 family
IC776_RS14055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC776_RS14070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC776_RS14075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS14090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC776_RS14095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IC776_RS14115	COG0741	lytic transglycosylase activity
IC776_RS14135	COG0584	glycerophosphoryl diester phosphodiesterase
IC776_RS14140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC776_RS14165	COG1597	lipid kinase activity
IC776_RS14180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IC776_RS14185	COG0477	Major facilitator Superfamily
IC776_RS14240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC776_RS14265	COG0505	Belongs to the CarA family
IC776_RS14285	COG0589	response to stress
IC776_RS14305	COG2843	Capsule synthesis protein
IC776_RS14325	COG2321	neutral zinc metallopeptidase
IC776_RS14330	COG2354	Protein conserved in bacteria
IC776_RS14350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC776_RS14375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IC776_RS14380	COG1053	succinate dehydrogenase
IC776_RS14385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IC776_RS14390	COG2009	succinate dehydrogenase
IC776_RS14425	COG2921	Belongs to the UPF0250 family
IC776_RS14430	COG0321	lipoyl(octanoyl) transferase activity
IC776_RS14445	COG0531	amino acid
IC776_RS14460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IC776_RS14465	COG1648	precorrin-2 dehydrogenase activity
IC776_RS14465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IC776_RS14480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IC776_RS14510	COG0671	phosphoesterase, PA-phosphatase related
IC776_RS14515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS14525	COG1538	Outer membrane efflux protein
IC776_RS14530	COG0393	Putative heavy-metal-binding
IC776_RS14535	COG0393	Putative heavy-metal-binding
IC776_RS14545	COG1028	Short-chain dehydrogenase reductase Sdr
IC776_RS14555	COG0525	valine-tRNA ligase activity
IC776_RS14575	COG0583	DNA-binding transcription factor activity
IC776_RS14580	COG0004	ammonium transporteR
IC776_RS14590	COG0642	Histidine kinase
IC776_RS14595	COG0745	RESPONSE REGULATOR receiver
IC776_RS14600	COG2194	sulfuric ester hydrolase activity
IC776_RS14625	COG1752	Esterase of the alpha-beta hydrolase superfamily
IC776_RS14640	COG2315	Protein conserved in bacteria
IC776_RS14645	COG0142	geranyltranstransferase activity
IC776_RS14650	COG2828	Protein conserved in bacteria
IC776_RS14655	COG1113	amino acid transport
IC776_RS14660	COG2816	NAD+ diphosphatase activity
IC776_RS14665	COG3046	protein related to deoxyribodipyrimidine photolyase
IC776_RS14695	COG2207	Transcriptional regulator
IC776_RS14720	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC776_RS14740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC776_RS14750	COG1530	ribonuclease E activity
IC776_RS14755	COG0424	maF-like protein
IC776_RS14760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IC776_RS14765	COG1792	Involved in formation and maintenance of cell shape
IC776_RS14770	COG1077	Cell shape determining protein MreB Mrl
IC776_RS14775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IC776_RS14785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IC776_RS14815	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IC776_RS14820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IC776_RS14825	COG1752	Esterase of the alpha-beta hydrolase superfamily
IC776_RS14830	COG1115	amino acid carrier protein
IC776_RS14850	COG2814	Major facilitator Superfamily
IC776_RS14855	COG1289	transmembrane transporter activity
IC776_RS14865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IC776_RS14905	COG1376	ErfK ybiS ycfS ynhG family protein
IC776_RS14910	COG2832	Protein of unknown function (DUF454)
IC776_RS14935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IC776_RS14950	COG0840	transmembrane signaling receptor activity
IC776_RS14990	COG3422	double-strand break repair
IC776_RS14995	COG2824	Alkylphosphonate utilization operon protein PhnA
IC776_RS15000	COG3189	MarR family transcriptional regulator
IC776_RS15010	COG0354	folic acid binding
IC776_RS15015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC776_RS15025	COG0679	Auxin Efflux Carrier
IC776_RS15030	COG1902	pentaerythritol trinitrate reductase activity
IC776_RS15035	COG4772	TonB-dependent receptor
IC776_RS15040	COG2094	Belongs to the DNA glycosylase MPG family
IC776_RS15065	COG1217	gtp-binding protein TYPA
IC776_RS15070	COG2233	PERMEase
IC776_RS15080	COG0833	amino acid
IC776_RS15085	COG1690	Belongs to the RtcB family
IC776_RS15095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IC776_RS15095	COG2885	chlorophyll binding
IC776_RS15105	COG0183	Belongs to the thiolase family
IC776_RS15120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC776_RS15140	COG2207	Transcriptional regulator
IC776_RS15145	COG0183	Belongs to the thiolase family
IC776_RS15165	COG2153	protein acetylation
IC776_RS15175	COG1272	protein, Hemolysin III
IC776_RS15180	COG0477	Major facilitator Superfamily
IC776_RS15195	COG0450	alkyl hydroperoxide reductase
IC776_RS15215	COG0285	dihydrofolate synthase activity
IC776_RS15270	COG2096	Adenosyltransferase
IC776_RS15290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IC776_RS15300	COG0745	RESPONSE REGULATOR receiver
IC776_RS15305	COG2205	protein histidine kinase activity
IC776_RS15315	COG1960	acyl-CoA dehydrogenase activity
IC776_RS15320	COG1960	acyl-CoA dehydrogenase activity
IC776_RS15355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IC776_RS15395	COG0438	transferase activity, transferring glycosyl groups
IC776_RS15400	COG0463	Glycosyl transferase, family 2
IC776_RS15405	COG0726	polysaccharide deacetylase
IC776_RS15415	COG2194	sulfuric ester hydrolase activity
IC776_RS15430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IC776_RS15475	COG1862	Preprotein translocase
IC776_RS15485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IC776_RS15490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IC776_RS15500	COG3781	membrane
IC776_RS15505	COG0613	PHP domain protein
IC776_RS15515	COG2350	Protein conserved in bacteria
IC776_RS15550	COG1607	acyl-coa hydrolase
IC776_RS15575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC776_RS15610	COG2199	diguanylate cyclase activity
IC776_RS15620	COG1408	metallophosphoesterase
IC776_RS15625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC776_RS15635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IC776_RS15655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IC776_RS15660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IC776_RS15665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IC776_RS15670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IC776_RS15675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IC776_RS15685	COG2969	positive regulation of protein catabolic process
IC776_RS15725	COG1960	acyl-CoA dehydrogenase activity
IC776_RS15730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IC776_RS15745	COG1309	transcriptional regulator
IC776_RS15800	COG1183	phosphatidylcholine synthase activity
IC776_RS15805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IC776_RS15835	COG1196	nuclear chromosome segregation
IC776_RS15835	COG0739	heme binding
IC776_RS15835	COG0741	lytic transglycosylase activity
IC776_RS15845	COG1702	phosphate starvation-inducible protein PhoH
IC776_RS15880	COG1295	ribonuclease BN
IC776_RS15890	COG2169	Transcriptional regulator
IC776_RS15895	COG0179	Fumarylacetoacetate (FAA) hydrolase
IC776_RS15940	COG0557	exoribonuclease II activity
IC776_RS15945	COG0339	signal peptide processing
IC776_RS15950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IC776_RS15980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IC776_RS15985	COG1960	acyl-CoA dehydrogenase activity
IC776_RS16120	COG0088	Forms part of the polypeptide exit tunnel
IC776_RS16125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IC776_RS16140	COG0626	cystathionine gamma-synthase activity
IC776_RS16145	COG0433	COG0433 Predicted ATPase
IC776_RS16150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC776_RS16150	COG1017	nitric oxide dioxygenase activity
IC776_RS16155	COG1959	2 iron, 2 sulfur cluster binding
IC776_RS16170	COG1301	dicarboxylic acid transport
IC776_RS16175	COG1946	Acyl-CoA thioesterase
IC776_RS16180	COG2937	Belongs to the GPAT DAPAT family
IC776_RS16195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IC776_RS16200	COG1040	competence protein
IC776_RS16205	COG0494	nUDIX hydrolase
IC776_RS16215	COG0598	Magnesium transport protein CorA
IC776_RS16225	COG2854	intermembrane phospholipid transfer
IC776_RS16235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IC776_RS16240	COG1127	ABC transporter
IC776_RS16245	COG0513	Belongs to the DEAD box helicase family
IC776_RS16265	COG0408	coproporphyrinogen oxidase activity
IC776_RS16280	COG1960	acyl-CoA dehydrogenase activity
IC776_RS16290	COG1983	PspC domain protein
IC776_RS16295	COG0517	IMP dehydrogenase activity
IC776_RS16295	COG0617	tRNA 3'-terminal CCA addition
IC776_RS16295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IC776_RS16310	COG0752	glycyl-tRNA synthetase alpha subunit
IC776_RS16330	COG0583	DNA-binding transcription factor activity
IC776_RS16335	COG1794	racemase activity, acting on amino acids and derivatives
IC776_RS16340	COG0583	DNA-binding transcription factor activity
IC776_RS16380	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS16390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC776_RS16395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IC776_RS16400	COG0833	amino acid
IC776_RS16430	COG1192	Involved in chromosome partitioning
IC776_RS16435	COG0628	permease
IC776_RS16445	COG1289	transmembrane transporter activity
IC776_RS16460	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC776_RS16465	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IC776_RS16475	COG0277	FAD linked oxidase domain protein
IC776_RS16480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IC776_RS16485	COG5006	permease, DMT superfamily
IC776_RS16505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IC776_RS16510	COG5380	lipid catabolic process
IC776_RS16520	COG0335	large ribosomal subunit rRNA binding
IC776_RS16530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IC776_RS16580	COG0194	GDP metabolic process
IC776_RS16595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC776_RS16615	COG3307	-O-antigen
IC776_RS16635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IC776_RS16640	COG1704	LemA family
IC776_RS16650	COG0493	'glutamate synthase
IC776_RS16655	COG0070	glutamate synthase
IC776_RS16655	COG0069	glutamate synthase activity
IC776_RS16655	COG0067	glutamate synthase
IC776_RS16705	COG2226	methyltransferase
IC776_RS16720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IC776_RS16725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IC776_RS16770	COG0833	amino acid
IC776_RS16790	COG0582	viral genome integration into host DNA
IC776_RS16915	COG0488	(ABC) transporter
IC776_RS16920	COG0028	Belongs to the TPP enzyme family
IC776_RS16930	COG4221	oxidoreductase activity
IC776_RS16935	COG0659	secondary active sulfate transmembrane transporter activity
IC776_RS16955	COG0427	acetyl-CoA hydrolase
IC776_RS16985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IC776_RS17015	COG0697	spore germination
IC776_RS17020	COG2329	Antibiotic biosynthesis monooxygenase
IC776_RS17035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IC776_RS17090	COG0582	viral genome integration into host DNA
IC776_RS17195	COG3177	Filamentation induced by cAMP protein fic
IC776_RS17210	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC776_RS17215	COG1733	regulation of RNA biosynthetic process
IC776_RS17240	COG1733	regulation of RNA biosynthetic process
IC776_RS17265	COG0667	Aldo Keto reductase
IC776_RS17285	COG0583	DNA-binding transcription factor activity
IC776_RS17290	COG2814	Major facilitator Superfamily
IC776_RS17325	COG1335	isochorismatase
IC776_RS17335	COG1012	belongs to the aldehyde dehydrogenase family
IC776_RS17340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC776_RS17350	COG1113	amino acid transport
IC776_RS17360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IC776_RS17375	COG2814	Major facilitator Superfamily
IC776_RS17385	COG0351	phosphomethylpyrimidine kinase
IC776_RS17385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IC776_RS17385	COG0352	thiamine-phosphate diphosphorylase activity
IC776_RS17395	COG4221	oxidoreductase activity
IC776_RS17415	COG1309	transcriptional regulator
IC776_RS17440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC776_RS17450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC776_RS17455	COG3162	membrane
IC776_RS17460	COG0784	Response regulator, receiver
IC776_RS17460	COG2198	Histidine kinase
IC776_RS17460	COG2205	protein histidine kinase activity
IC776_RS17485	COG1522	sequence-specific DNA binding
IC776_RS17490	COG1335	isochorismatase
IC776_RS17495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC776_RS17505	COG0668	transmembrane transport
IC776_RS17510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IC776_RS17515	COG1519	Transferase
IC776_RS17520	COG1902	pentaerythritol trinitrate reductase activity
IC776_RS17540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IC776_RS17565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC776_RS17565	COG0426	domain, Protein
IC776_RS17570	COG2119	membrane
IC776_RS17580	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC776_RS17590	COG4942	peptidase
IC776_RS17605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IC776_RS17615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IC776_RS17635	COG0189	ligase activity
IC776_RS17655	COG0708	Exodeoxyribonuclease III
IC776_RS17660	COG1393	Belongs to the ArsC family
IC776_RS17675	COG3706	GGDEF domain
IC776_RS17710	COG2351	hydroxyisourate hydrolase activity
IC776_RS17715	COG2233	PERMEase
IC776_RS17725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC776_RS17735	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IC776_RS17745	COG3150	esterase
IC776_RS17825	COG2918	glutathione biosynthetic process
IC776_RS17840	COG2733	membrane
IC776_RS17845	COG0436	Aminotransferase
IC776_RS17850	COG0534	Mate efflux family protein
IC776_RS17945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IC776_RS17950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IC776_RS17960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IC776_RS17965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IC776_RS17975	COG1196	nuclear chromosome segregation
IC776_RS17990	COG1280	lysine exporter protein (LysE YggA)
IC776_RS17995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IC776_RS18000	COG0546	phosphoglycolate phosphatase activity
IC776_RS18010	COG0010	Belongs to the arginase family
IC776_RS18040	COG2188	Transcriptional regulator
IC776_RS18050	COG0523	cobalamin synthesis protein
IC776_RS18060	COG1113	amino acid transport
IC776_RS18070	COG0625	glutathione transferase activity
IC776_RS18075	COG0346	lactoylglutathione lyase activity
IC776_RS18090	COG1683	Conserved Protein
IC776_RS18095	COG0534	Mate efflux family protein
IC776_RS18100	COG0385	Bile acid
IC776_RS18105	COG1335	isochorismatase
IC776_RS18110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC776_RS18130	COG2116	formate transmembrane transporter activity
IC776_RS18135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IC776_RS18140	COG2133	pyrroloquinoline quinone binding
IC776_RS18145	COG2983	Belongs to the UPF0260 family
IC776_RS18150	COG5487	UPF0391 membrane protein
IC776_RS18165	COG1194	a g-specific adenine glycosylase
IC776_RS18180	COG2818	Glycosylase
IC776_RS18190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC776_RS18210	COG0656	L-ascorbic acid biosynthetic process
IC776_RS18215	COG2814	Major facilitator Superfamily
IC776_RS18250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC776_RS18265	COG2233	PERMEase
IC776_RS18305	COG0733	neurotransmitter:sodium symporter activity
IC776_RS18315	COG0625	glutathione transferase activity
IC776_RS18345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IC776_RS18350	COG0657	acetylesterase activity
IC776_RS18400	COG2951	lytic endotransglycosylase activity
IC776_RS18405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IC776_RS18420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IC776_RS18430	COG0671	phosphoesterase, PA-phosphatase related
IC776_RS18435	COG0861	Integral membrane protein TerC family
IC776_RS18445	COG0402	S-adenosylhomocysteine deaminase activity
IC776_RS18460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC776_RS18570	COG2816	NAD+ diphosphatase activity
IC776_RS18575	COG3046	protein related to deoxyribodipyrimidine photolyase
IC776_RS18590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC776_RS18615	COG1192	Involved in chromosome partitioning
IC776_RS18670	COG0667	Aldo Keto reductase
IC776_RS18765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC776_RS18770	COG0501	Belongs to the peptidase M48B family
IC776_RS18795	COG0542	response to heat
IC776_RS18825	COG0582	viral genome integration into host DNA
IC776_RS18840	COG2130	NADP-dependent
IC776_RS18845	COG1309	transcriptional regulator
IC776_RS18855	COG1902	pentaerythritol trinitrate reductase activity
IC776_RS18865	COG1979	alcohol dehydrogenase
IC776_RS18880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IC776_RS18910	COG0477	Major facilitator Superfamily
IC776_RS18915	COG0697	spore germination
IC776_RS18925	COG0604	alcohol dehydrogenase
IC776_RS18925	COG3321	synthase
IC776_RS18930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IC776_RS18955	COG2801	Transposase and inactivated derivatives
IC776_RS18970	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IC776_RS18995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IC776_RS19005	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
IC776_RS19105	COG3706	GGDEF domain
IC776_RS19120	COG2801	Transposase and inactivated derivatives