locus-tag	class	description
IC778_RS00010	COG0592	DNA-directed DNA polymerase activity
IC778_RS00020	COG0187	DNA topoisomerase II activity
IC778_RS00030	COG0586	Pfam SNARE associated Golgi protein
IC778_RS00035	COG0488	(ABC) transporter
IC778_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IC778_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IC778_RS00110	COG1047	Peptidyl-prolyl cis-trans
IC778_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IC778_RS00125	COG0196	riboflavin kinase activity
IC778_RS00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IC778_RS00140	COG1309	transcriptional regulator
IC778_RS00145	COG1116	anion transmembrane transporter activity
IC778_RS00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_RS00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_RS00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_RS00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_RS00170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IC778_RS00170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IC778_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS00190	COG0546	phosphoglycolate phosphatase activity
IC778_RS00245	COG3023	N-Acetylmuramoyl-L-alanine amidase
IC778_RS00250	COG0728	peptidoglycan biosynthetic process
IC778_RS00275	COG1596	polysaccharide export
IC778_RS00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IC778_RS00290	COG1091	dTDP-4-dehydrorhamnose reductase activity
IC778_RS00295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IC778_RS00305	COG1086	Polysaccharide biosynthesis protein
IC778_RS00340	COG1216	Glycosyl transferase, family 2
IC778_RS00340	COG0463	Glycosyl transferase, family 2
IC778_RS00345	COG0110	maltose O-acetyltransferase activity
IC778_RS00360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IC778_RS00365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IC778_RS00385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IC778_RS00395	COG2186	Transcriptional regulator
IC778_RS00405	COG0277	FAD linked oxidase domain protein
IC778_RS00410	COG1448	Aminotransferase
IC778_RS00420	COG1802	Transcriptional regulator
IC778_RS00435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IC778_RS00505	COG0564	pseudouridine synthase activity
IC778_RS00545	COG0251	oxidation-reduction process
IC778_RS00550	COG1113	amino acid transport
IC778_RS00555	COG1113	amino acid transport
IC778_RS00575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC778_RS00580	COG1960	acyl-CoA dehydrogenase activity
IC778_RS00585	COG1024	Enoyl-CoA hydratase
IC778_RS00590	COG1024	Enoyl-CoA hydratase
IC778_RS00595	COG0477	Major facilitator Superfamily
IC778_RS00600	COG3916	Acyl-homoserine-lactone synthase
IC778_RS00610	COG2197	response regulator
IC778_RS00620	COG1960	acyl-CoA dehydrogenase activity
IC778_RS00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IC778_RS00625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IC778_RS00625	COG3321	synthase
IC778_RS00625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IC778_RS00665	COG0271	Belongs to the BolA IbaG family
IC778_RS00675	COG1192	Involved in chromosome partitioning
IC778_RS00690	COG0586	Pfam SNARE associated Golgi protein
IC778_RS00695	COG2259	Doxx family
IC778_RS00700	COG4399	Belongs to the UPF0754 family
IC778_RS00700	COG4399	Belongs to the UPF0754 family
IC778_RS00705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC778_RS00705	COG0519	Catalyzes the synthesis of GMP from XMP
IC778_RS00710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC778_RS00720	COG0735	belongs to the Fur family
IC778_RS00755	COG0281	malic enzyme
IC778_RS00765	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS00775	COG1280	lysine exporter protein (LysE YggA)
IC778_RS00780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IC778_RS00785	COG1121	(ABC) transporter
IC778_RS00835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IC778_RS00840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IC778_RS00850	COG0386	Belongs to the glutathione peroxidase family
IC778_RS00865	COG1309	transcriptional regulator
IC778_RS00870	COG0697	spore germination
IC778_RS00880	COG0758	DNA mediated transformation
IC778_RS00915	COG1309	transcriptional regulator
IC778_RS00950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC778_RS00965	COG0655	NAD(P)H dehydrogenase (quinone) activity
IC778_RS01000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IC778_RS01010	COG2814	Major facilitator Superfamily
IC778_RS01020	COG1253	flavin adenine dinucleotide binding
IC778_RS01030	COG2860	membrane
IC778_RS01035	COG0477	Major facilitator Superfamily
IC778_RS01045	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_RS01060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IC778_RS01075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC778_RS01080	COG0235	Class ii aldolase
IC778_RS01085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_RS01090	COG0431	NADPH-dependent FMN reductase
IC778_RS01095	COG0606	chelatase, subunit chli
IC778_RS01105	COG0347	Belongs to the P(II) protein family
IC778_RS01110	COG0004	ammonium transporteR
IC778_RS01120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC778_RS01120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC778_RS01155	COG0795	lipopolysaccharide-transporting ATPase activity
IC778_RS01160	COG0795	lipopolysaccharide-transporting ATPase activity
IC778_RS01165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IC778_RS01170	COG0793	Belongs to the peptidase S41A family
IC778_RS01185	COG2197	response regulator
IC778_RS01195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IC778_RS01205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_RS01210	COG4974	Belongs to the 'phage' integrase family
IC778_RS01240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC778_RS01245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IC778_RS01255	COG0494	nUDIX hydrolase
IC778_RS01275	COG0697	spore germination
IC778_RS01285	COG1538	Outer membrane efflux protein
IC778_RS01305	COG3275	phosphorelay sensor kinase activity
IC778_RS01315	COG0181	hydroxymethylbilane synthase activity
IC778_RS01360	COG1716	ATPase activity
IC778_RS01365	COG0546	phosphoglycolate phosphatase activity
IC778_RS01460	COG0596	Alpha beta hydrolase
IC778_RS01465	COG2056	Na+-H+ antiporter family
IC778_RS01480	COG0326	Molecular chaperone. Has ATPase activity
IC778_RS01495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IC778_RS01560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IC778_RS01575	COG1289	transmembrane transporter activity
IC778_RS01590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IC778_RS01600	COG0497	DNA recombination
IC778_RS01610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC778_RS01620	COG0237	dephospho-CoA kinase activity
IC778_RS01670	COG0195	Participates in both transcription termination and antitermination
IC778_RS01680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IC778_RS01685	COG1320	monovalent cation:proton antiporter activity
IC778_RS01690	COG2212	antiporter activity
IC778_RS01695	COG1863	multisubunit Na H antiporter MnhE subunit
IC778_RS01700	COG0651	ATP synthesis coupled electron transport
IC778_RS01705	COG1006	Multisubunit Na H antiporter MnhC subunit
IC778_RS01710	COG2111	Na H antiporter
IC778_RS01710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IC778_RS01725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IC778_RS01740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_RS01755	COG2226	methyltransferase
IC778_RS01780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IC778_RS01785	COG1074	ATP-dependent DNA helicase activity
IC778_RS01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IC778_RS01795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IC778_RS01805	COG1185	polyribonucleotide nucleotidyltransferase activity
IC778_RS01810	COG0598	Magnesium transport protein CorA
IC778_RS01815	COG0789	Transcriptional regulator
IC778_RS01820	COG0484	heat shock protein binding
IC778_RS01830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IC778_RS01835	COG0475	glutathione-regulated potassium exporter activity
IC778_RS01835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC778_RS01840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IC778_RS01865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC778_RS01875	COG4535	Mg2 and Co2 transporter CorC
IC778_RS01890	COG0644	oxidoreductase
IC778_RS01890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IC778_RS01900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IC778_RS01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_RS01920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IC778_RS01930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC778_RS01930	COG0493	'glutamate synthase
IC778_RS01960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IC778_RS01975	COG0534	Mate efflux family protein
IC778_RS01985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IC778_RS01990	COG4221	oxidoreductase activity
IC778_RS01995	COG0583	DNA-binding transcription factor activity
IC778_RS02010	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_RS02015	COG1530	ribonuclease E activity
IC778_RS02030	COG2378	regulation of single-species biofilm formation
IC778_RS02035	COG0625	glutathione transferase activity
IC778_RS02045	COG0583	DNA-binding transcription factor activity
IC778_RS02090	COG0583	DNA-binding transcription factor activity
IC778_RS02115	COG0473	3-isopropylmalate dehydrogenase activity
IC778_RS02170	COG1301	dicarboxylic acid transport
IC778_RS02180	COG1560	Kdo2-lipid A biosynthetic process
IC778_RS02185	COG1280	lysine exporter protein (LysE YggA)
IC778_RS02195	COG0488	(ABC) transporter
IC778_RS02200	COG2900	Belongs to the SlyX family
IC778_RS02210	COG1733	regulation of RNA biosynthetic process
IC778_RS02235	COG0210	DNA helicase
IC778_RS02240	COG0724	RNA recognition motif
IC778_RS02260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC778_RS02260	COG4651	solute:proton antiporter activity
IC778_RS02285	COG0788	formyltetrahydrofolate deformylase activity
IC778_RS02390	COG2813	Specifically methylates the guanine in position
IC778_RS02390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC778_RS02400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IC778_RS02410	COG4774	siderophore transport
IC778_RS02420	COG0740	serine-type endopeptidase activity
IC778_RS02440	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IC778_RS02440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IC778_RS02445	COG0280	phosphate acetyltransferase
IC778_RS02445	COG0857	belongs to the CobB CobQ family
IC778_RS02450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IC778_RS02460	COG0800	Aldolase
IC778_RS02470	COG3265	gluconokinase activity
IC778_RS02475	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS02500	COG0793	Belongs to the peptidase S41A family
IC778_RS02535	COG1426	Protein conserved in bacteria
IC778_RS02575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IC778_RS02585	COG1162	GTPase activity
IC778_RS02590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IC778_RS02605	COG1538	Outer membrane efflux protein
IC778_RS02610	COG0577	efflux transmembrane transporter activity
IC778_RS02610	COG1136	(ABC) transporter
IC778_RS02615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS02640	COG0028	Belongs to the TPP enzyme family
IC778_RS02645	COG0440	acetolactate synthase activity
IC778_RS02650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IC778_RS02685	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IC778_RS02700	COG0084	hydrolase, TatD family'
IC778_RS02710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IC778_RS02720	COG0583	DNA-binding transcription factor activity
IC778_RS02730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC778_RS02835	COG2814	Major facilitator Superfamily
IC778_RS02850	COG1230	cation diffusion facilitator family transporter
IC778_RS02875	COG2814	Major facilitator Superfamily
IC778_RS02885	COG0697	spore germination
IC778_RS02920	COG3622	Belongs to the hyi family
IC778_RS02925	COG2084	Dehydrogenase
IC778_RS02930	COG1024	Enoyl-CoA hydratase
IC778_RS02935	COG2205	protein histidine kinase activity
IC778_RS02935	COG5002	protein histidine kinase activity
IC778_RS02935	COG0784	Response regulator, receiver
IC778_RS02955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC778_RS02965	COG3956	TIGRFAM MazG family protein
IC778_RS02970	COG1555	photosystem II stabilization
IC778_RS02975	COG0617	tRNA 3'-terminal CCA addition
IC778_RS02980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IC778_RS03005	COG3028	Belongs to the UPF0307 family
IC778_RS03010	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_RS03025	COG0625	glutathione transferase activity
IC778_RS03030	COG1238	metal cluster binding
IC778_RS03040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IC778_RS03070	COG0072	phenylalanine-tRNA ligase activity
IC778_RS03100	COG0248	Ppx GppA phosphatase
IC778_RS03110	COG0037	tRNA processing
IC778_RS03150	COG1764	response to oxidative stress
IC778_RS03155	COG1846	Transcriptional regulator
IC778_RS03165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC778_RS03225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IC778_RS03230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IC778_RS03235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IC778_RS03245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IC778_RS03295	COG1214	PFAM Peptidase M22, glycoprotease
IC778_RS03310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IC778_RS03320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IC778_RS03325	COG0561	phosphatase activity
IC778_RS03335	COG2132	Multicopper oxidase
IC778_RS03360	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS03370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IC778_RS03375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IC778_RS03405	COG1063	alcohol dehydrogenase
IC778_RS03410	COG0583	DNA-binding transcription factor activity
IC778_RS03415	COG1960	acyl-CoA dehydrogenase activity
IC778_RS03420	COG2814	Major facilitator Superfamily
IC778_RS03425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC778_RS03435	COG1309	transcriptional regulator
IC778_RS03450	COG1053	succinate dehydrogenase
IC778_RS03455	COG0583	DNA-binding transcription factor activity
IC778_RS03470	COG0583	DNA-binding transcription factor activity
IC778_RS03480	COG0583	DNA-binding transcription factor activity
IC778_RS03495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_RS03540	COG0583	DNA-binding transcription factor activity
IC778_RS03545	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IC778_RS03575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IC778_RS03595	COG0745	RESPONSE REGULATOR receiver
IC778_RS03610	COG3706	GGDEF domain
IC778_RS03635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IC778_RS03650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC778_RS03665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IC778_RS03670	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC778_RS03695	COG0583	DNA-binding transcription factor activity
IC778_RS03715	COG0668	transmembrane transport
IC778_RS03725	COG2081	HI0933 family
IC778_RS03730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IC778_RS03765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC778_RS03765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC778_RS03775	COG0489	protein tyrosine kinase activity
IC778_RS03780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IC778_RS03825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC778_RS03835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IC778_RS03850	COG0730	response to heat
IC778_RS03860	COG1196	nuclear chromosome segregation
IC778_RS03880	COG2223	nitrite transmembrane transporter activity
IC778_RS03885	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IC778_RS03890	COG1877	trehalose-phosphatase activity
IC778_RS03895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC778_RS03895	COG2226	methyltransferase
IC778_RS03895	COG0596	Alpha beta hydrolase
IC778_RS03910	COG4106	trans-aconitate 2-methyltransferase activity
IC778_RS03925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IC778_RS03930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IC778_RS03935	COG0009	L-threonylcarbamoyladenylate synthase
IC778_RS03940	COG3101	peptidyl-lysine hydroxylation
IC778_RS03945	COG1399	metal-binding, possibly nucleic acid-binding protein
IC778_RS03970	COG1652	LysM domain
IC778_RS03975	COG0351	phosphomethylpyrimidine kinase
IC778_RS03975	COG0352	thiamine-phosphate diphosphorylase activity
IC778_RS03975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IC778_RS03985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IC778_RS04015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC778_RS04045	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IC778_RS04060	COG0358	DNA primase activity
IC778_RS04095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC778_RS04115	COG0583	DNA-binding transcription factor activity
IC778_RS04120	COG0473	3-isopropylmalate dehydrogenase activity
IC778_RS04130	COG0657	acetylesterase activity
IC778_RS04135	COG4638	Rieske (2fe-2S)
IC778_RS04140	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS04160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IC778_RS04160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC778_RS04170	COG1981	membrane
IC778_RS04185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IC778_RS04195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IC778_RS04215	COG0456	acetyltransferase
IC778_RS04225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IC778_RS04230	COG0492	ferredoxin-NADP+ reductase activity
IC778_RS04235	COG1674	ftsk spoiiie
IC778_RS04240	COG1280	lysine exporter protein (LysE YggA)
IC778_RS04255	COG2894	cell division
IC778_RS04270	COG0204	Acyl-transferase
IC778_RS04275	COG2885	chlorophyll binding
IC778_RS04280	COG0210	DNA helicase
IC778_RS04290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IC778_RS04305	COG0121	glutamine amidotransferase
IC778_RS04320	COG2914	Belongs to the UPF0125 (RnfH) family
IC778_RS04325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IC778_RS04330	COG0735	belongs to the Fur family
IC778_RS04350	COG1968	undecaprenyl-diphosphatase activity
IC778_RS04360	COG0420	3'-5' exonuclease activity
IC778_RS04380	COG1090	epimerase
IC778_RS04395	COG2050	protein possibly involved in aromatic compounds catabolism
IC778_RS04405	COG2814	Major facilitator Superfamily
IC778_RS04410	COG0405	Gamma-glutamyltransferase
IC778_RS04470	COG3586	endonuclease activity
IC778_RS04500	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS04520	COG0477	Major facilitator Superfamily
IC778_RS04525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC778_RS04545	COG0531	amino acid
IC778_RS04550	COG2040	homocysteine
IC778_RS04575	COG1309	transcriptional regulator
IC778_RS04580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC778_RS04585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC778_RS04595	COG1607	acyl-coa hydrolase
IC778_RS04605	COG0523	cobalamin synthesis protein
IC778_RS04615	COG4681	YaeQ
IC778_RS04625	COG0726	polysaccharide deacetylase
IC778_RS04625	COG1649	PFAM Uncharacterised BCR, COG1649
IC778_RS04630	COG1215	transferase activity, transferring glycosyl groups
IC778_RS04640	COG1024	Enoyl-CoA hydratase
IC778_RS04670	COG1414	Transcriptional regulator
IC778_RS04705	COG2271	Major facilitator Superfamily
IC778_RS04715	COG2267	carboxylic ester hydrolase activity
IC778_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS04735	COG0028	Belongs to the TPP enzyme family
IC778_RS04750	COG0242	peptide deformylase activity
IC778_RS04755	COG2066	Belongs to the glutaminase family
IC778_RS04760	COG2207	Transcriptional regulator
IC778_RS04765	COG2223	nitrite transmembrane transporter activity
IC778_RS04800	COG0306	phosphate transporter
IC778_RS04820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC778_RS04865	COG4181	ATPase activity
IC778_RS04870	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IC778_RS04895	COG0583	DNA-binding transcription factor activity
IC778_RS04905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_RS04910	COG1773	rubredoxin
IC778_RS04960	COG2851	Citrate transporter
IC778_RS04965	COG1253	flavin adenine dinucleotide binding
IC778_RS05005	COG0804	urea catabolic process
IC778_RS05015	COG0830	nickel cation binding
IC778_RS05035	COG0742	ribosomal rna small subunit methyltransferase
IC778_RS05040	COG0768	penicillin binding
IC778_RS05065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IC778_RS05070	COG2878	Part of a membrane complex involved in electron transport
IC778_RS05075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IC778_RS05085	COG3384	dioxygenase
IC778_RS05120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IC778_RS05150	COG1674	ftsk spoiiie
IC778_RS05480	COG0006	proline dipeptidase activity
IC778_RS05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_RS05490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_RS05515	COG0583	DNA-binding transcription factor activity
IC778_RS05560	COG0741	lytic transglycosylase activity
IC778_RS05560	COG1388	LysM domain
IC778_RS05570	COG4174	ABC transporter (Permease)
IC778_RS05575	COG4239	(ABC) transporter, permease
IC778_RS05580	COG4172	Belongs to the ABC transporter superfamily
IC778_RS05605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IC778_RS05615	COG5001	Diguanylate cyclase
IC778_RS05615	COG4251	negative regulation of phosphorylation
IC778_RS05615	COG3706	GGDEF domain
IC778_RS05615	COG2203	Gaf domain
IC778_RS05625	COG0446	pyridine nucleotide-disulphide oxidoreductase
IC778_RS05625	COG1902	pentaerythritol trinitrate reductase activity
IC778_RS05640	COG0251	oxidation-reduction process
IC778_RS05650	COG0583	DNA-binding transcription factor activity
IC778_RS05670	COG4269	membrane
IC778_RS05720	COG1846	Transcriptional regulator
IC778_RS05770	COG1113	amino acid transport
IC778_RS05780	COG0531	amino acid
IC778_RS05800	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS05820	COG1113	amino acid transport
IC778_RS05840	COG0697	spore germination
IC778_RS05860	COG1960	acyl-CoA dehydrogenase activity
IC778_RS05870	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS05875	COG1024	Enoyl-CoA hydratase
IC778_RS05880	COG2814	Major facilitator Superfamily
IC778_RS05895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_RS05915	COG1944	ATP diphosphatase activity
IC778_RS05945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IC778_RS05960	COG0583	DNA-binding transcription factor activity
IC778_RS05965	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IC778_RS05970	COG2072	flavoprotein involved in K transport
IC778_RS05985	COG1309	transcriptional regulator
IC778_RS05990	COG1741	Belongs to the pirin family
IC778_RS06005	COG2072	flavoprotein involved in K transport
IC778_RS06015	COG2252	PERMEase
IC778_RS06020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IC778_RS06025	COG3038	cytochrome b561
IC778_RS06035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IC778_RS06045	COG0527	aspartate kinase activity
IC778_RS06055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IC778_RS06070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IC778_RS06085	COG0667	Aldo Keto reductase
IC778_RS06095	COG1765	OsmC-like protein
IC778_RS06110	COG0542	response to heat
IC778_RS06155	COG0625	glutathione transferase activity
IC778_RS06160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IC778_RS06180	COG3634	alkyl hydroperoxide reductase activity
IC778_RS06200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_RS06215	COG1643	Atp-dependent helicase
IC778_RS06235	COG2814	Major facilitator Superfamily
IC778_RS06240	COG3135	benzoate transporter
IC778_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS06250	COG0543	2 iron, 2 sulfur cluster binding
IC778_RS06250	COG0633	Ferredoxin
IC778_RS06255	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IC778_RS06260	COG4638	Rieske (2fe-2S)
IC778_RS06270	COG0583	DNA-binding transcription factor activity
IC778_RS06280	COG2871	sodium ion transport
IC778_RS06365	COG1570	exodeoxyribonuclease VII activity
IC778_RS06400	COG1280	lysine exporter protein (LysE YggA)
IC778_RS06405	COG1278	Cold shock
IC778_RS06435	COG2814	Major facilitator Superfamily
IC778_RS06445	COG0667	Aldo Keto reductase
IC778_RS06465	COG0517	IMP dehydrogenase activity
IC778_RS06465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IC778_RS06470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IC778_RS06480	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IC778_RS06485	COG1137	ATPase activity
IC778_RS06490	COG1538	Outer membrane efflux protein
IC778_RS06520	COG4122	O-methyltransferase activity
IC778_RS06530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IC778_RS06585	COG1560	Kdo2-lipid A biosynthetic process
IC778_RS06605	COG1469	GTP cyclohydrolase I activity
IC778_RS06615	COG1294	oxidase, subunit
IC778_RS06620	COG1271	oxidase subunit
IC778_RS06630	COG0583	DNA-binding transcription factor activity
IC778_RS06635	COG0402	S-adenosylhomocysteine deaminase activity
IC778_RS06650	COG2814	Major facilitator Superfamily
IC778_RS06670	COG4774	siderophore transport
IC778_RS06675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC778_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS06695	COG1522	sequence-specific DNA binding
IC778_RS06700	COG0626	cystathionine gamma-synthase activity
IC778_RS06710	COG1278	Cold shock
IC778_RS06715	COG1309	transcriptional regulator
IC778_RS06795	COG3209	COG3209 Rhs family protein
IC778_RS06810	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS06850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC778_RS06855	COG3713	MltA-interacting MipA family protein
IC778_RS06870	COG2076	Multidrug Resistance protein
IC778_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS06900	COG3220	belongs to the UPF0276 family
IC778_RS06910	COG1595	DNA-templated transcription, initiation
IC778_RS06920	COG0583	DNA-binding transcription factor activity
IC778_RS06925	COG1914	H( )-stimulated, divalent metal cation uptake system
IC778_RS06945	COG4770	biotin carboxylase activity
IC778_RS06950	COG0038	chloride channel
IC778_RS07000	COG1063	alcohol dehydrogenase
IC778_RS07015	COG0439	Biotin carboxylase
IC778_RS07020	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_RS07025	COG1733	regulation of RNA biosynthetic process
IC778_RS07040	COG0864	Transcriptional regulator
IC778_RS07050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC778_RS07055	COG1116	anion transmembrane transporter activity
IC778_RS07080	COG0477	Major facilitator Superfamily
IC778_RS07185	COG0590	tRNA wobble adenosine to inosine editing
IC778_RS07190	COG2807	transmembrane transport
IC778_RS07205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_RS07210	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IC778_RS07220	COG0789	Transcriptional regulator
IC778_RS07230	COG1760	l-serine dehydratase
IC778_RS07235	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS07235	COG2030	dehydratase
IC778_RS07240	COG3396	Phenylacetate-CoA oxygenase
IC778_RS07245	COG3460	Phenylacetate-CoA oxygenase
IC778_RS07250	COG3396	Phenylacetate-CoA oxygenase
IC778_RS07255	COG2151	metal-sulfur cluster biosynthetic enzyme
IC778_RS07260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_RS07265	COG1024	Enoyl-CoA hydratase
IC778_RS07270	COG1024	Enoyl-CoA hydratase
IC778_RS07275	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_RS07285	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IC778_RS07290	COG3327	negative regulation of DNA-templated transcription, initiation
IC778_RS07300	COG2050	protein possibly involved in aromatic compounds catabolism
IC778_RS07310	COG0406	alpha-ribazole phosphatase activity
IC778_RS07330	COG3179	chitinase
IC778_RS07380	COG1309	transcriptional regulator
IC778_RS07385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC778_RS07400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IC778_RS07405	COG0531	amino acid
IC778_RS07410	COG0753	catalase activity
IC778_RS07415	COG3038	cytochrome b561
IC778_RS07435	COG0583	DNA-binding transcription factor activity
IC778_RS07445	COG1414	Transcriptional regulator
IC778_RS07450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_RS07465	COG1840	ABC-type Fe3 transport system, periplasmic component
IC778_RS07470	COG3842	ATPase activity
IC778_RS07485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IC778_RS07490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IC778_RS07495	COG2814	Major facilitator Superfamily
IC778_RS07500	COG1960	acyl-CoA dehydrogenase activity
IC778_RS07505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC778_RS07515	COG1024	Enoyl-CoA hydratase
IC778_RS07540	COG0183	Belongs to the thiolase family
IC778_RS07545	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS07555	COG1024	Enoyl-CoA hydratase
IC778_RS07560	COG1960	acyl-CoA dehydrogenase activity
IC778_RS07585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC778_RS07595	COG2814	Major facilitator Superfamily
IC778_RS07605	COG1960	acyl-CoA dehydrogenase activity
IC778_RS07620	COG0583	DNA-binding transcription factor activity
IC778_RS07630	COG4770	biotin carboxylase activity
IC778_RS07635	COG1024	Enoyl-CoA hydratase
IC778_RS07640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IC778_RS07645	COG1960	acyl-CoA dehydrogenase activity
IC778_RS07650	COG1309	transcriptional regulator
IC778_RS07655	COG0318	PFAM AMP-dependent synthetase and ligase
IC778_RS07675	COG0583	DNA-binding transcription factor activity
IC778_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS07740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IC778_RS07800	COG0765	amino acid transport
IC778_RS07805	COG0765	amino acid transport
IC778_RS07815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC778_RS07820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IC778_RS07830	COG1280	lysine exporter protein (LysE YggA)
IC778_RS07835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IC778_RS07845	COG1045	serine acetyltransferase
IC778_RS07860	COG0583	DNA-binding transcription factor activity
IC778_RS07865	COG0625	glutathione transferase activity
IC778_RS07870	COG0625	glutathione transferase activity
IC778_RS07875	COG0583	DNA-binding transcription factor activity
IC778_RS07885	COG1346	cytolysis
IC778_RS07910	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IC778_RS07915	COG3052	prosthetic group binding
IC778_RS07935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IC778_RS07955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_RS07965	COG1294	oxidase, subunit
IC778_RS07970	COG1271	oxidase subunit
IC778_RS07990	COG0477	Major facilitator Superfamily
IC778_RS08000	COG4521	taurine ABC transporter
IC778_RS08005	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IC778_RS08010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_RS08015	COG2175	clavaminate synthase activity
IC778_RS08025	COG1953	Uracil, thiamine, allantoin
IC778_RS08035	COG0583	DNA-binding transcription factor activity
IC778_RS08045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IC778_RS08060	COG0640	Transcriptional regulator
IC778_RS08065	COG0798	PFAM Bile acid sodium symporter
IC778_RS08070	COG0431	NADPH-dependent FMN reductase
IC778_RS08075	COG0583	DNA-binding transcription factor activity
IC778_RS08090	COG3634	alkyl hydroperoxide reductase activity
IC778_RS08125	COG1301	dicarboxylic acid transport
IC778_RS08130	COG0436	Aminotransferase
IC778_RS08140	COG0386	Belongs to the glutathione peroxidase family
IC778_RS08145	COG2207	Transcriptional regulator
IC778_RS08145	COG1917	Cupin 2, conserved barrel domain protein
IC778_RS08180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IC778_RS08205	COG0012	GTP binding
IC778_RS08210	COG2011	ABC-type metal ion transport system permease component
IC778_RS08215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IC778_RS08225	COG1464	Belongs to the NlpA lipoprotein family
IC778_RS08255	COG0765	amino acid transport
IC778_RS08260	COG0765	amino acid transport
IC778_RS08265	COG1126	abc transporter atp-binding protein
IC778_RS08275	COG1522	sequence-specific DNA binding
IC778_RS08300	COG2197	response regulator
IC778_RS08320	COG0583	DNA-binding transcription factor activity
IC778_RS08330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IC778_RS08340	COG0697	spore germination
IC778_RS08360	COG3121	Chaperone
IC778_RS08365	COG3539	Fimbrial protein
IC778_RS08390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IC778_RS08390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IC778_RS08430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IC778_RS08445	COG2353	YceI-like domain
IC778_RS08455	COG3698	Phosphodiester glycosidase
IC778_RS08470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IC778_RS08475	COG0506	proline dehydrogenase activity
IC778_RS08475	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IC778_RS08475	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IC778_RS08485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC778_RS08490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IC778_RS08510	COG1132	(ABC) transporter
IC778_RS08515	COG3122	Protein conserved in bacteria
IC778_RS08520	COG3619	membrane
IC778_RS08540	COG2850	peptidyl-arginine hydroxylation
IC778_RS08545	COG0424	maF-like protein
IC778_RS08585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IC778_RS08595	COG1192	Involved in chromosome partitioning
IC778_RS08600	COG1475	DNA binding
IC778_RS08605	COG0811	peptide transport
IC778_RS08615	COG1132	(ABC) transporter
IC778_RS08640	COG0084	hydrolase, TatD family'
IC778_RS08705	COG0776	regulation of translation
IC778_RS08720	COG2431	L-lysine efflux transmembrane transporter activity
IC778_RS08735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IC778_RS08785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IC778_RS08805	COG0305	Participates in initiation and elongation during chromosome replication
IC778_RS08885	COG4695	Portal protein
IC778_RS09005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IC778_RS09030	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IC778_RS09055	COG0601	transmembrane transport
IC778_RS09060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IC778_RS09065	COG4172	Belongs to the ABC transporter superfamily
IC778_RS09095	COG0702	epimerase
IC778_RS09100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IC778_RS09120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IC778_RS09150	COG0316	Belongs to the HesB IscA family
IC778_RS09155	COG0822	iron-sulfur transferase activity
IC778_RS09180	COG0776	regulation of translation
IC778_RS09185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IC778_RS09190	COG2207	Transcriptional regulator
IC778_RS09195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_RS09200	COG1960	acyl-CoA dehydrogenase activity
IC778_RS09205	COG1960	acyl-CoA dehydrogenase activity
IC778_RS09220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IC778_RS09225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IC778_RS09240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IC778_RS09245	COG0406	alpha-ribazole phosphatase activity
IC778_RS09260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IC778_RS09265	COG0730	response to heat
IC778_RS09285	COG4773	Receptor
IC778_RS09290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC778_RS09305	COG1131	(ABC) transporter
IC778_RS09310	COG0842	Transport permease protein
IC778_RS09315	COG0842	Transport permease protein
IC778_RS09365	COG2226	methyltransferase
IC778_RS09390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IC778_RS09415	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS09430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC778_RS09440	COG0133	tryptophan synthase activity
IC778_RS09455	COG3706	GGDEF domain
IC778_RS09470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IC778_RS09475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IC778_RS09480	COG0022	dehydrogenase e1 component
IC778_RS09485	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_RS09490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_RS09500	COG1063	alcohol dehydrogenase
IC778_RS09505	COG3781	membrane
IC778_RS09515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_RS09515	COG3453	Protein conserved in bacteria
IC778_RS09525	COG0730	response to heat
IC778_RS09540	COG3708	Transcriptional regulator
IC778_RS09540	COG2207	Transcriptional regulator
IC778_RS09550	COG0477	Major facilitator Superfamily
IC778_RS09560	COG1027	Aspartate ammonia-lyase
IC778_RS09575	COG0583	DNA-binding transcription factor activity
IC778_RS09580	COG0583	DNA-binding transcription factor activity
IC778_RS09585	COG0183	Belongs to the thiolase family
IC778_RS09590	COG2031	fatty acid transporter
IC778_RS09605	COG0583	DNA-binding transcription factor activity
IC778_RS09630	COG2814	Major facilitator Superfamily
IC778_RS09660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_RS09665	COG2610	gluconate transmembrane transporter activity
IC778_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS09675	COG2207	Transcriptional regulator
IC778_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS09705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_RS09720	COG0543	2 iron, 2 sulfur cluster binding
IC778_RS09720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_RS09725	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IC778_RS09730	COG4638	Rieske (2fe-2S)
IC778_RS09740	COG0725	ABC transporter, periplasmic molybdate-binding protein
IC778_RS09745	COG4149	molybdate abc transporter
IC778_RS09750	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IC778_RS09775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC778_RS09780	COG3251	PFAM MbtH domain protein
IC778_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS09795	COG1169	isochorismate synthase
IC778_RS09800	COG1021	2,3-dihydroxybenzoate-AMP ligase
IC778_RS09805	COG3433	isochorismatase activity
IC778_RS09805	COG1535	isochorismatase
IC778_RS09810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_RS09815	COG4771	TonB-dependent receptor
IC778_RS09875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_RS09880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS09885	COG0745	RESPONSE REGULATOR receiver
IC778_RS09900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC778_RS09905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IC778_RS09915	COG0753	catalase activity
IC778_RS09925	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IC778_RS09950	COG3539	Fimbrial protein
IC778_RS09980	COG0601	transmembrane transport
IC778_RS09985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IC778_RS10005	COG1132	(ABC) transporter
IC778_RS10010	COG1132	(ABC) transporter
IC778_RS10030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_RS10040	COG0805	protein transport
IC778_RS10045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IC778_RS10060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_RS10065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_RS10070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_RS10075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_RS10105	COG4771	TonB-dependent receptor
IC778_RS10110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_RS10115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_RS10145	COG2175	clavaminate synthase activity
IC778_RS10160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_RS10165	COG0667	Aldo Keto reductase
IC778_RS10180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC778_RS10185	COG2175	clavaminate synthase activity
IC778_RS10280	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS10305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC778_RS10325	COG1120	ATPase activity
IC778_RS10330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IC778_RS10360	COG1566	PFAM secretion protein HlyD family protein
IC778_RS10370	COG2271	Major facilitator Superfamily
IC778_RS10385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_RS10400	COG2188	Transcriptional regulator
IC778_RS10480	COG1309	transcriptional regulator
IC778_RS10505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IC778_RS10535	COG0583	DNA-binding transcription factor activity
IC778_RS10540	COG4948	Mandelate Racemase Muconate Lactonizing
IC778_RS10545	COG4829	muconolactone delta-isomerase
IC778_RS10555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IC778_RS10560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC778_RS10565	COG0183	Belongs to the thiolase family
IC778_RS10570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC778_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS10590	COG3733	amine oxidase
IC778_RS10600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS10620	COG4638	Rieske (2fe-2S)
IC778_RS10640	COG0154	amidase activity
IC778_RS10650	COG2814	Major facilitator Superfamily
IC778_RS10675	COG1960	acyl-CoA dehydrogenase activity
IC778_RS10680	COG0583	DNA-binding transcription factor activity
IC778_RS10685	COG1414	Transcriptional regulator
IC778_RS10700	COG2391	methyltransferase activity
IC778_RS10710	COG4993	Dehydrogenase
IC778_RS10715	COG3659	wide pore channel activity
IC778_RS10720	COG3420	alginic acid biosynthetic process
IC778_RS10725	COG0710	3-dehydroquinate dehydratase activity
IC778_RS10730	COG3485	protocatechuate 3,4-dioxygenase
IC778_RS10735	COG3485	protocatechuate 3,4-dioxygenase
IC778_RS10740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IC778_RS10745	COG2271	Major facilitator Superfamily
IC778_RS10750	COG0596	Alpha beta hydrolase
IC778_RS10755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IC778_RS10760	COG0183	Belongs to the thiolase family
IC778_RS10765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IC778_RS10770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IC778_RS10780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IC778_RS10790	COG2323	membrane
IC778_RS10795	COG0148	phosphopyruvate hydratase activity
IC778_RS10835	COG1902	pentaerythritol trinitrate reductase activity
IC778_RS10835	COG0446	pyridine nucleotide-disulphide oxidoreductase
IC778_RS10860	COG0542	response to heat
IC778_RS10865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IC778_RS10895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IC778_RS10900	COG0569	domain protein
IC778_RS10905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IC778_RS10920	COG4774	siderophore transport
IC778_RS10925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IC778_RS10935	COG1585	Membrane protein implicated in regulation of membrane protease activity
IC778_RS10950	COG1294	oxidase, subunit
IC778_RS10955	COG4890	Cyd operon protein YbgT
IC778_RS10980	COG0552	protein localization to endoplasmic reticulum
IC778_RS11005	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IC778_RS11010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC778_RS11015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IC778_RS11025	COG0583	DNA-binding transcription factor activity
IC778_RS11030	COG0024	Methionine aminopeptidase
IC778_RS11060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IC778_RS11060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IC778_RS11065	COG1105	Belongs to the carbohydrate kinase PfkB family
IC778_RS11070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IC778_RS11070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IC778_RS11070	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IC778_RS11095	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS11115	COG0659	secondary active sulfate transmembrane transporter activity
IC778_RS11130	COG1113	amino acid transport
IC778_RS11140	COG1522	sequence-specific DNA binding
IC778_RS11155	COG1011	Hydrolase
IC778_RS11160	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IC778_RS11170	COG2137	regulation of response to DNA damage stimulus
IC778_RS11185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC778_RS11205	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IC778_RS11220	COG0575	Belongs to the CDS family
IC778_RS11225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IC778_RS11250	COG3852	Histidine kinase
IC778_RS11255	COG2204	response regulator
IC778_RS11310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IC778_RS11315	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IC778_RS11335	COG0697	spore germination
IC778_RS11350	COG0303	'Molybdopterin
IC778_RS11355	COG0315	cyclic pyranopterin monophosphate synthase activity
IC778_RS11355	COG0521	Mo-molybdopterin cofactor biosynthetic process
IC778_RS11370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IC778_RS11375	COG0243	molybdopterin cofactor binding
IC778_RS11385	COG0243	molybdopterin cofactor binding
IC778_RS11390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_RS11395	COG2146	nitrite reductase [NAD(P)H] activity
IC778_RS11395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_RS11405	COG0745	RESPONSE REGULATOR receiver
IC778_RS11410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_RS11410	COG1116	anion transmembrane transporter activity
IC778_RS11430	COG0511	ligase activity, forming carbon-carbon bonds
IC778_RS11490	COG0069	glutamate synthase activity
IC778_RS11520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IC778_RS11535	COG1335	isochorismatase
IC778_RS11545	COG1454	alcohol dehydrogenase
IC778_RS11550	COG0824	Thioesterase
IC778_RS11560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IC778_RS11585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IC778_RS11590	COG2030	dehydratase
IC778_RS11595	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS11600	COG0183	Belongs to the thiolase family
IC778_RS11610	COG0583	DNA-binding transcription factor activity
IC778_RS11615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IC778_RS11625	COG1522	sequence-specific DNA binding
IC778_RS11630	COG3135	benzoate transporter
IC778_RS11655	COG0589	response to stress
IC778_RS11660	COG0488	(ABC) transporter
IC778_RS11705	COG0668	transmembrane transport
IC778_RS11715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC778_RS11720	COG2423	ornithine cyclodeaminase activity
IC778_RS11725	COG4264	IucA IucC family
IC778_RS11735	COG4264	IucA IucC family
IC778_RS11775	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS11785	COG1605	Chorismate mutase
IC778_RS11800	COG0625	glutathione transferase activity
IC778_RS11830	COG0308	aminopeptidase N
IC778_RS11850	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IC778_RS11860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IC778_RS11865	COG1454	alcohol dehydrogenase
IC778_RS11885	COG0531	amino acid
IC778_RS11890	COG4303	Ethanolamine ammonia lyase large subunit
IC778_RS11895	COG4302	ethanolamine ammonia-lyase activity
IC778_RS11900	COG0519	Catalyzes the synthesis of GMP from XMP
IC778_RS11900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC778_RS11905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC778_RS11930	COG0697	spore germination
IC778_RS11935	COG1923	regulation of RNA biosynthetic process
IC778_RS11945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IC778_RS11950	COG0802	atpase or kinase
IC778_RS11970	COG1187	pseudouridine synthase activity
IC778_RS11985	COG0583	DNA-binding transcription factor activity
IC778_RS11995	COG2814	Major facilitator Superfamily
IC778_RS12000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC778_RS12030	COG0729	surface antigen
IC778_RS12050	COG0174	glutamine synthetase
IC778_RS12055	COG0745	RESPONSE REGULATOR receiver
IC778_RS12060	COG2205	protein histidine kinase activity
IC778_RS12065	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IC778_RS12070	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IC778_RS12075	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IC778_RS12100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_RS12105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC778_RS12110	COG1960	acyl-CoA dehydrogenase activity
IC778_RS12125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IC778_RS12130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IC778_RS12135	COG2890	protein-(glutamine-N5) methyltransferase activity
IC778_RS12155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_RS12165	COG3658	cytochrome
IC778_RS12170	COG1215	transferase activity, transferring glycosyl groups
IC778_RS12175	COG1649	PFAM Uncharacterised BCR, COG1649
IC778_RS12175	COG0726	polysaccharide deacetylase
IC778_RS12205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IC778_RS12215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IC778_RS12240	COG0305	Participates in initiation and elongation during chromosome replication
IC778_RS12245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IC778_RS12255	COG1305	Transglutaminase-like
IC778_RS12265	COG2308	Evidence 4 Homologs of previously reported genes of
IC778_RS12295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IC778_RS12300	COG0138	bifunctional purine biosynthesis protein purh
IC778_RS12305	COG0151	Belongs to the GarS family
IC778_RS12310	COG1464	Belongs to the NlpA lipoprotein family
IC778_RS12315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IC778_RS12320	COG2011	ABC-type metal ion transport system permease component
IC778_RS12335	COG1301	dicarboxylic acid transport
IC778_RS12380	COG2855	membrane
IC778_RS12395	COG2814	Major facilitator Superfamily
IC778_RS12400	COG3246	L-lysine catabolic process to acetate
IC778_RS12405	COG2175	clavaminate synthase activity
IC778_RS12430	COG0745	RESPONSE REGULATOR receiver
IC778_RS12435	COG0642	Histidine kinase
IC778_RS12440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IC778_RS12485	COG5002	protein histidine kinase activity
IC778_RS12500	COG2351	hydroxyisourate hydrolase activity
IC778_RS12510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IC778_RS12510	COG3008	intermembrane lipid transfer
IC778_RS12515	COG2995	paraquat-inducible protein a
IC778_RS12540	COG2985	domain, Protein
IC778_RS12555	COG2169	Transcriptional regulator
IC778_RS12555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IC778_RS12565	COG1309	transcriptional regulator
IC778_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS12645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IC778_RS12645	COG0475	glutathione-regulated potassium exporter activity
IC778_RS12650	COG0786	glutamate:sodium symporter activity
IC778_RS12660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IC778_RS12670	COG0596	Alpha beta hydrolase
IC778_RS12690	COG0583	DNA-binding transcription factor activity
IC778_RS12695	COG1335	isochorismatase
IC778_RS12765	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS12805	COG2815	serine threonine protein kinase
IC778_RS12805	COG0515	serine threonine protein kinase
IC778_RS12835	COG1610	YqeY-like protein
IC778_RS12895	COG0778	Nitroreductase
IC778_RS12905	COG0513	Belongs to the DEAD box helicase family
IC778_RS12925	COG2363	Small membrane protein
IC778_RS12950	COG4650	regulator
IC778_RS12955	COG1234	tRNA 3'-trailer cleavage
IC778_RS12960	COG1690	Belongs to the RtcB family
IC778_RS12980	COG2195	Cleaves the N-terminal amino acid of tripeptides
IC778_RS12985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC778_RS12995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IC778_RS13015	COG1960	acyl-CoA dehydrogenase activity
IC778_RS13020	COG1301	dicarboxylic acid transport
IC778_RS13030	COG3139	Protein of unknown function (DUF1315)
IC778_RS13035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IC778_RS13040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IC778_RS13050	COG0494	nUDIX hydrolase
IC778_RS13060	COG0642	Histidine kinase
IC778_RS13075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC778_RS13085	COG1720	tRNA m6t6A37 methyltransferase activity
IC778_RS13095	COG0384	phenazine biosynthesis protein PhzF
IC778_RS13100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC778_RS13105	COG0826	peptidase U32
IC778_RS13110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC778_RS13120	COG4598	ABC transporter
IC778_RS13125	COG4160	amino acid transport
IC778_RS13130	COG4215	(ABC) transporter
IC778_RS13145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS13185	COG1131	(ABC) transporter
IC778_RS13190	COG0842	Transport permease protein
IC778_RS13205	COG0772	Belongs to the SEDS family
IC778_RS13210	COG2951	lytic endotransglycosylase activity
IC778_RS13235	COG2207	Transcriptional regulator
IC778_RS13250	COG0052	Belongs to the universal ribosomal protein uS2 family
IC778_RS13255	COG0024	Methionine aminopeptidase
IC778_RS13265	COG2223	nitrite transmembrane transporter activity
IC778_RS13275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_RS13280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IC778_RS13285	COG1960	acyl-CoA dehydrogenase activity
IC778_RS13300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IC778_RS13305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IC778_RS13310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IC778_RS13330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC778_RS13335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IC778_RS13340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IC778_RS13375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IC778_RS13385	COG0174	glutamine synthetase
IC778_RS13400	COG0512	Glutamine amidotransferase of anthranilate synthase
IC778_RS13415	COG2840	Smr protein MutS2
IC778_RS13425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IC778_RS13435	COG0302	gtp cyclohydrolase
IC778_RS13455	COG3739	integral membrane protein
IC778_RS13470	COG1741	Belongs to the pirin family
IC778_RS13480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IC778_RS13485	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS13495	COG2964	Protein conserved in bacteria
IC778_RS13505	COG2423	ornithine cyclodeaminase activity
IC778_RS13510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IC778_RS13550	COG2814	Major facilitator Superfamily
IC778_RS13580	COG2879	small protein
IC778_RS13585	COG1966	Carbon starvation protein
IC778_RS13590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IC778_RS13605	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IC778_RS13630	COG1067	ATP-dependent peptidase activity
IC778_RS13635	COG0583	DNA-binding transcription factor activity
IC778_RS13660	COG1686	Belongs to the peptidase S11 family
IC778_RS13665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IC778_RS13690	COG3647	Membrane
IC778_RS13705	COG0616	signal peptide processing
IC778_RS13710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IC778_RS13720	COG0573	inorganic phosphate transmembrane transporter activity
IC778_RS13725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IC778_RS13730	COG1113	amino acid transport
IC778_RS13735	COG3961	Belongs to the TPP enzyme family
IC778_RS13740	COG1522	sequence-specific DNA binding
IC778_RS13750	COG0076	glutamate decarboxylase activity
IC778_RS13755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC778_RS13780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_RS13815	COG0352	thiamine-phosphate diphosphorylase activity
IC778_RS13850	COG0612	Peptidase, M16
IC778_RS13860	COG1823	symporter activity
IC778_RS13865	COG0583	DNA-binding transcription factor activity
IC778_RS13870	COG0477	Major facilitator Superfamily
IC778_RS13895	COG1187	pseudouridine synthase activity
IC778_RS13910	COG1686	Belongs to the peptidase S11 family
IC778_RS13915	COG1252	NADH dehydrogenase
IC778_RS13925	COG0415	Belongs to the DNA photolyase family
IC778_RS13940	COG1215	transferase activity, transferring glycosyl groups
IC778_RS13955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IC778_RS13970	COG2070	2-Nitropropane dioxygenase
IC778_RS14025	COG0556	nucleotide-excision repair
IC778_RS14030	COG3706	GGDEF domain
IC778_RS14050	COG0436	Aminotransferase
IC778_RS14075	COG4221	oxidoreductase activity
IC778_RS14085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IC778_RS14090	COG1381	Involved in DNA repair and RecF pathway recombination
IC778_RS14100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IC778_RS14115	COG0681	Belongs to the peptidase S26 family
IC778_RS14120	COG0481	GTPase activity
IC778_RS14130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC778_RS14150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IC778_RS14155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IC778_RS14160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IC778_RS14170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IC778_RS14175	COG4208	sulfate ABC transporter
IC778_RS14180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IC778_RS14185	COG0583	DNA-binding transcription factor activity
IC778_RS14190	COG4625	pathogenesis
IC778_RS14200	COG0602	queuosine metabolic process
IC778_RS14205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IC778_RS14220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IC778_RS14235	COG1051	belongs to the nudix hydrolase family
IC778_RS14235	COG1056	cytidyltransferase-related domain
IC778_RS14240	COG1024	Enoyl-CoA hydratase
IC778_RS14245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IC778_RS14265	COG2814	Major facilitator Superfamily
IC778_RS14270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IC778_RS14270	COG0047	phosphoribosylformylglycinamidine synthase activity
IC778_RS14295	COG1473	amidohydrolase
IC778_RS14300	COG0824	Thioesterase
IC778_RS14320	COG0823	Involved in the tonB-independent uptake of proteins
IC778_RS14340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC778_RS14375	COG0628	permease
IC778_RS14385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IC778_RS14390	COG0596	Alpha beta hydrolase
IC778_RS14395	COG0616	signal peptide processing
IC778_RS14395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IC778_RS14405	COG0658	competence protein
IC778_RS14405	COG2333	competence protein COMEC
IC778_RS14410	COG1136	(ABC) transporter
IC778_RS14415	COG4591	ABC-type transport system involved in lipoprotein release permease component
IC778_RS14450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS14470	COG0463	Glycosyl transferase, family 2
IC778_RS14480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IC778_RS14490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_RS14510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IC778_RS14515	COG1280	lysine exporter protein (LysE YggA)
IC778_RS14530	COG0019	diaminopimelate decarboxylase activity
IC778_RS14540	COG1113	amino acid transport
IC778_RS14545	COG1115	amino acid carrier protein
IC778_RS14670	COG0681	Belongs to the peptidase S26 family
IC778_RS14705	COG4373	Mu-like prophage FluMu protein gp28
IC778_RS14715	COG4383	Mu-like prophage protein gp29
IC778_RS14740	COG4397	Mu-like prophage major head subunit gpT
IC778_RS14830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IC778_RS14835	COG0243	molybdopterin cofactor binding
IC778_RS14840	COG1929	Belongs to the glycerate kinase type-1 family
IC778_RS14855	COG0778	Nitroreductase
IC778_RS14860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_RS14865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS14885	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS14890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IC778_RS14895	COG0583	DNA-binding transcription factor activity
IC778_RS14900	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS14905	COG0596	Alpha beta hydrolase
IC778_RS14910	COG0596	Alpha beta hydrolase
IC778_RS14910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_RS14915	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_RS14915	COG0596	Alpha beta hydrolase
IC778_RS14920	COG1902	pentaerythritol trinitrate reductase activity
IC778_RS14925	COG1309	transcriptional regulator
IC778_RS14985	COG3811	Belongs to the UPF0386 family
IC778_RS15005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC778_RS15020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_RS15025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS15045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC778_RS15050	COG0183	Belongs to the thiolase family
IC778_RS15055	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_RS15060	COG1024	Enoyl-CoA hydratase
IC778_RS15065	COG1960	acyl-CoA dehydrogenase activity
IC778_RS15070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IC778_RS15070	COG0644	oxidoreductase
IC778_RS15135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC778_RS15160	COG1002	Type II restriction enzyme, methylase subunits
IC778_RS15165	COG1061	Type III restriction enzyme res subunit
IC778_RS15175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IC778_RS15215	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IC778_RS15235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC778_RS15260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IC778_RS15280	COG0741	lytic transglycosylase activity
IC778_RS15300	COG0584	glycerophosphoryl diester phosphodiesterase
IC778_RS15305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC778_RS15325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IC778_RS15330	COG1597	lipid kinase activity
IC778_RS15345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IC778_RS15350	COG0477	Major facilitator Superfamily
IC778_RS15400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IC778_RS15405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC778_RS15430	COG0505	Belongs to the CarA family
IC778_RS15450	COG0589	response to stress
IC778_RS15470	COG2321	neutral zinc metallopeptidase
IC778_RS15475	COG2354	Protein conserved in bacteria
IC778_RS15495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_RS15520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IC778_RS15525	COG1053	succinate dehydrogenase
IC778_RS15530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IC778_RS15535	COG2009	succinate dehydrogenase
IC778_RS15570	COG2921	Belongs to the UPF0250 family
IC778_RS15575	COG0321	lipoyl(octanoyl) transferase activity
IC778_RS15590	COG0531	amino acid
IC778_RS15600	COG1733	regulation of RNA biosynthetic process
IC778_RS15605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IC778_RS15610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IC778_RS15610	COG1648	precorrin-2 dehydrogenase activity
IC778_RS15625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IC778_RS15655	COG0671	phosphoesterase, PA-phosphatase related
IC778_RS15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS15670	COG1538	Outer membrane efflux protein
IC778_RS15675	COG0393	Putative heavy-metal-binding
IC778_RS15680	COG0393	Putative heavy-metal-binding
IC778_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
IC778_RS15700	COG0525	valine-tRNA ligase activity
IC778_RS15710	COG0525	valine-tRNA ligase activity
IC778_RS15730	COG0583	DNA-binding transcription factor activity
IC778_RS15735	COG0004	ammonium transporteR
IC778_RS15745	COG0642	Histidine kinase
IC778_RS15750	COG0745	RESPONSE REGULATOR receiver
IC778_RS15755	COG2194	sulfuric ester hydrolase activity
IC778_RS15775	COG1752	Esterase of the alpha-beta hydrolase superfamily
IC778_RS15790	COG2315	Protein conserved in bacteria
IC778_RS15795	COG0142	geranyltranstransferase activity
IC778_RS15800	COG2828	Protein conserved in bacteria
IC778_RS15805	COG1113	amino acid transport
IC778_RS15810	COG2816	NAD+ diphosphatase activity
IC778_RS15815	COG3046	protein related to deoxyribodipyrimidine photolyase
IC778_RS15845	COG2207	Transcriptional regulator
IC778_RS15870	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_RS15890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IC778_RS15900	COG1530	ribonuclease E activity
IC778_RS15905	COG0424	maF-like protein
IC778_RS15910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IC778_RS15915	COG1792	Involved in formation and maintenance of cell shape
IC778_RS15920	COG1077	Cell shape determining protein MreB Mrl
IC778_RS15925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IC778_RS15935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IC778_RS15965	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IC778_RS15970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IC778_RS15975	COG1752	Esterase of the alpha-beta hydrolase superfamily
IC778_RS15980	COG1115	amino acid carrier protein
IC778_RS16000	COG2814	Major facilitator Superfamily
IC778_RS16005	COG1289	transmembrane transporter activity
IC778_RS16055	COG1376	ErfK ybiS ycfS ynhG family protein
IC778_RS16060	COG2832	Protein of unknown function (DUF454)
IC778_RS16085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IC778_RS16100	COG0840	transmembrane signaling receptor activity
IC778_RS16140	COG3422	double-strand break repair
IC778_RS16145	COG2824	Alkylphosphonate utilization operon protein PhnA
IC778_RS16150	COG3189	MarR family transcriptional regulator
IC778_RS16155	COG0596	Alpha beta hydrolase
IC778_RS16165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IC778_RS16170	COG1335	isochorismatase
IC778_RS16175	COG0251	oxidation-reduction process
IC778_RS16180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_RS16185	COG2233	PERMEase
IC778_RS16200	COG0354	folic acid binding
IC778_RS16205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_RS16215	COG0679	Auxin Efflux Carrier
IC778_RS16220	COG1902	pentaerythritol trinitrate reductase activity
IC778_RS16225	COG4772	TonB-dependent receptor
IC778_RS16230	COG2094	Belongs to the DNA glycosylase MPG family
IC778_RS16255	COG1217	gtp-binding protein TYPA
IC778_RS16260	COG2233	PERMEase
IC778_RS16270	COG0833	amino acid
IC778_RS16275	COG1690	Belongs to the RtcB family
IC778_RS16285	COG2885	chlorophyll binding
IC778_RS16285	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IC778_RS16295	COG0183	Belongs to the thiolase family
IC778_RS16310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC778_RS16330	COG2207	Transcriptional regulator
IC778_RS16335	COG0183	Belongs to the thiolase family
IC778_RS16355	COG2153	protein acetylation
IC778_RS16365	COG1272	protein, Hemolysin III
IC778_RS16370	COG0477	Major facilitator Superfamily
IC778_RS16385	COG0450	alkyl hydroperoxide reductase
IC778_RS16405	COG0285	dihydrofolate synthase activity
IC778_RS16455	COG4206	TonB-dependent receptor
IC778_RS16460	COG2096	Adenosyltransferase
IC778_RS16480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IC778_RS16490	COG0745	RESPONSE REGULATOR receiver
IC778_RS16495	COG2205	protein histidine kinase activity
IC778_RS16505	COG1960	acyl-CoA dehydrogenase activity
IC778_RS16510	COG1960	acyl-CoA dehydrogenase activity
IC778_RS16545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IC778_RS16565	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS16590	COG0438	transferase activity, transferring glycosyl groups
IC778_RS16595	COG0463	Glycosyl transferase, family 2
IC778_RS16600	COG0726	polysaccharide deacetylase
IC778_RS16610	COG2194	sulfuric ester hydrolase activity
IC778_RS16625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IC778_RS16635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IC778_RS16670	COG1862	Preprotein translocase
IC778_RS16680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IC778_RS16685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IC778_RS16695	COG3781	membrane
IC778_RS16700	COG0613	PHP domain protein
IC778_RS16710	COG2350	Protein conserved in bacteria
IC778_RS16745	COG1607	acyl-coa hydrolase
IC778_RS16770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC778_RS16805	COG2199	diguanylate cyclase activity
IC778_RS16815	COG1408	metallophosphoesterase
IC778_RS16820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC778_RS16830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IC778_RS16850	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IC778_RS16855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IC778_RS16860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IC778_RS16865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IC778_RS16870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IC778_RS16880	COG2969	positive regulation of protein catabolic process
IC778_RS16915	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC778_RS16915	COG1024	Enoyl-CoA hydratase
IC778_RS16920	COG1960	acyl-CoA dehydrogenase activity
IC778_RS16925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IC778_RS16940	COG1309	transcriptional regulator
IC778_RS16945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IC778_RS17010	COG1183	phosphatidylcholine synthase activity
IC778_RS17015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IC778_RS17045	COG0739	heme binding
IC778_RS17045	COG0741	lytic transglycosylase activity
IC778_RS17045	COG1196	nuclear chromosome segregation
IC778_RS17055	COG1702	phosphate starvation-inducible protein PhoH
IC778_RS17090	COG1295	ribonuclease BN
IC778_RS17100	COG2169	Transcriptional regulator
IC778_RS17105	COG0179	Fumarylacetoacetate (FAA) hydrolase
IC778_RS17150	COG0557	exoribonuclease II activity
IC778_RS17155	COG0339	signal peptide processing
IC778_RS17160	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IC778_RS17190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IC778_RS17195	COG1960	acyl-CoA dehydrogenase activity
IC778_RS17245	COG1841	ribosomal large subunit assembly
IC778_RS17330	COG0088	Forms part of the polypeptide exit tunnel
IC778_RS17335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IC778_RS17350	COG0626	cystathionine gamma-synthase activity
IC778_RS17355	COG0433	COG0433 Predicted ATPase
IC778_RS17360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC778_RS17360	COG1017	nitric oxide dioxygenase activity
IC778_RS17365	COG1959	2 iron, 2 sulfur cluster binding
IC778_RS17380	COG1301	dicarboxylic acid transport
IC778_RS17385	COG1946	Acyl-CoA thioesterase
IC778_RS17390	COG2937	Belongs to the GPAT DAPAT family
IC778_RS17405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IC778_RS17410	COG1040	competence protein
IC778_RS17415	COG0494	nUDIX hydrolase
IC778_RS17425	COG0598	Magnesium transport protein CorA
IC778_RS17435	COG2854	intermembrane phospholipid transfer
IC778_RS17445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IC778_RS17450	COG1127	ABC transporter
IC778_RS17455	COG0513	Belongs to the DEAD box helicase family
IC778_RS17475	COG0408	coproporphyrinogen oxidase activity
IC778_RS17490	COG1960	acyl-CoA dehydrogenase activity
IC778_RS17500	COG1983	PspC domain protein
IC778_RS17505	COG0517	IMP dehydrogenase activity
IC778_RS17530	COG0752	glycyl-tRNA synthetase alpha subunit
IC778_RS17550	COG0583	DNA-binding transcription factor activity
IC778_RS17555	COG1794	racemase activity, acting on amino acids and derivatives
IC778_RS17560	COG0583	DNA-binding transcription factor activity
IC778_RS17600	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS17610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC778_RS17615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IC778_RS17620	COG0833	amino acid
IC778_RS17625	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS17655	COG1192	Involved in chromosome partitioning
IC778_RS17660	COG0628	permease
IC778_RS17670	COG1289	transmembrane transporter activity
IC778_RS17685	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_RS17690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IC778_RS17700	COG0277	FAD linked oxidase domain protein
IC778_RS17705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IC778_RS17710	COG5006	permease, DMT superfamily
IC778_RS17730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IC778_RS17735	COG5380	lipid catabolic process
IC778_RS17745	COG0335	large ribosomal subunit rRNA binding
IC778_RS17755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IC778_RS17770	COG4969	Belongs to the N-Me-Phe pilin family
IC778_RS17795	COG4969	Belongs to the N-Me-Phe pilin family
IC778_RS17810	COG0194	GDP metabolic process
IC778_RS17825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC778_RS17845	COG3307	-O-antigen
IC778_RS17855	COG4969	Belongs to the N-Me-Phe pilin family
IC778_RS17865	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IC778_RS17870	COG1704	LemA family
IC778_RS17880	COG0493	'glutamate synthase
IC778_RS17885	COG0067	glutamate synthase
IC778_RS17885	COG0069	glutamate synthase activity
IC778_RS17885	COG0070	glutamate synthase
IC778_RS17935	COG2226	methyltransferase
IC778_RS17950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IC778_RS17955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IC778_RS18000	COG0833	amino acid
IC778_RS18075	COG0488	(ABC) transporter
IC778_RS18080	COG0028	Belongs to the TPP enzyme family
IC778_RS18090	COG4221	oxidoreductase activity
IC778_RS18095	COG0659	secondary active sulfate transmembrane transporter activity
IC778_RS18125	COG0427	acetyl-CoA hydrolase
IC778_RS18155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IC778_RS18200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IC778_RS18265	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC778_RS18270	COG1733	regulation of RNA biosynthetic process
IC778_RS18300	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS18305	COG1733	regulation of RNA biosynthetic process
IC778_RS18325	COG0667	Aldo Keto reductase
IC778_RS18345	COG0583	DNA-binding transcription factor activity
IC778_RS18350	COG2814	Major facilitator Superfamily
IC778_RS18385	COG1335	isochorismatase
IC778_RS18395	COG1012	belongs to the aldehyde dehydrogenase family
IC778_RS18400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC778_RS18410	COG1113	amino acid transport
IC778_RS18420	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IC778_RS18440	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS18480	COG2814	Major facilitator Superfamily
IC778_RS18490	COG0351	phosphomethylpyrimidine kinase
IC778_RS18490	COG0352	thiamine-phosphate diphosphorylase activity
IC778_RS18490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IC778_RS18500	COG4221	oxidoreductase activity
IC778_RS18520	COG1309	transcriptional regulator
IC778_RS18540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC778_RS18550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC778_RS18555	COG3162	membrane
IC778_RS18560	COG2205	protein histidine kinase activity
IC778_RS18560	COG2198	Histidine kinase
IC778_RS18560	COG0784	Response regulator, receiver
IC778_RS18585	COG1522	sequence-specific DNA binding
IC778_RS18590	COG1335	isochorismatase
IC778_RS18595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC778_RS18605	COG0668	transmembrane transport
IC778_RS18610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IC778_RS18615	COG1519	Transferase
IC778_RS18620	COG1902	pentaerythritol trinitrate reductase activity
IC778_RS18640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IC778_RS18665	COG0426	domain, Protein
IC778_RS18665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IC778_RS18670	COG2119	membrane
IC778_RS18680	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC778_RS18690	COG4942	peptidase
IC778_RS18705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IC778_RS18715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IC778_RS18735	COG0189	ligase activity
IC778_RS18760	COG0708	Exodeoxyribonuclease III
IC778_RS18765	COG1393	Belongs to the ArsC family
IC778_RS18780	COG3706	GGDEF domain
IC778_RS18795	COG0666	response to abiotic stimulus
IC778_RS18795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IC778_RS18815	COG2351	hydroxyisourate hydrolase activity
IC778_RS18830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC778_RS18840	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IC778_RS18850	COG3150	esterase
IC778_RS18890	COG1388	LysM domain
IC778_RS18890	COG1705	Flagellar rod assembly protein muramidase FlgJ
IC778_RS18905	COG2918	glutathione biosynthetic process
IC778_RS18920	COG2733	membrane
IC778_RS18925	COG0436	Aminotransferase
IC778_RS18930	COG0534	Mate efflux family protein
IC778_RS19025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IC778_RS19030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IC778_RS19040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IC778_RS19070	COG1280	lysine exporter protein (LysE YggA)
IC778_RS19075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IC778_RS19080	COG0546	phosphoglycolate phosphatase activity
IC778_RS19090	COG0010	Belongs to the arginase family
IC778_RS19120	COG2188	Transcriptional regulator
IC778_RS19130	COG0523	cobalamin synthesis protein
IC778_RS19140	COG1113	amino acid transport
IC778_RS19150	COG0625	glutathione transferase activity
IC778_RS19155	COG0346	lactoylglutathione lyase activity
IC778_RS19170	COG1683	Conserved Protein
IC778_RS19175	COG0534	Mate efflux family protein
IC778_RS19180	COG0385	Bile acid
IC778_RS19185	COG1335	isochorismatase
IC778_RS19190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC778_RS19210	COG2116	formate transmembrane transporter activity
IC778_RS19215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IC778_RS19220	COG2133	pyrroloquinoline quinone binding
IC778_RS19225	COG2983	Belongs to the UPF0260 family
IC778_RS19230	COG5487	UPF0391 membrane protein
IC778_RS19245	COG1194	a g-specific adenine glycosylase
IC778_RS19260	COG2818	Glycosylase
IC778_RS19265	COG1064	alcohol dehydrogenase
IC778_RS19285	COG0583	DNA-binding transcription factor activity
IC778_RS19290	COG0656	L-ascorbic acid biosynthetic process
IC778_RS19295	COG2814	Major facilitator Superfamily
IC778_RS19330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC778_RS19345	COG2233	PERMEase
IC778_RS19385	COG0733	neurotransmitter:sodium symporter activity
IC778_RS19395	COG0625	glutathione transferase activity
IC778_RS19425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IC778_RS19430	COG0657	acetylesterase activity
IC778_RS19480	COG2951	lytic endotransglycosylase activity
IC778_RS19485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IC778_RS19500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IC778_RS19510	COG0671	phosphoesterase, PA-phosphatase related
IC778_RS19515	COG0861	Integral membrane protein TerC family
IC778_RS19525	COG0754	glutathionylspermidine amidase activity
IC778_RS19535	COG0402	S-adenosylhomocysteine deaminase activity
IC778_RS19550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_RS19760	COG0501	Belongs to the peptidase M48B family
IC778_RS19800	COG4372	Transposase
IC778_RS19825	COG0589	response to stress
IC778_RS19830	COG0659	secondary active sulfate transmembrane transporter activity
IC778_RS19860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IC778_RS19965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IC778_RS20040	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS20050	COG2826	transposase and inactivated derivatives, IS30 family
IC778_RS20150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC778_RS20200	COG1192	Involved in chromosome partitioning
IC778_RS20215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IC778_RS20260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IC778_RS20290	COG0477	Major facilitator Superfamily
IC778_RS20295	COG0697	spore germination
IC778_RS20305	COG0604	alcohol dehydrogenase
IC778_RS20305	COG3321	synthase
IC778_RS20310	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IC778_RS20315	COG0583	DNA-binding transcription factor activity
IC778_RS20320	COG3328	transposase activity
IC778_RS20335	COG0659	secondary active sulfate transmembrane transporter activity
IC778_RS20340	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IC778_RS20375	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
IC778_RS20530	COG0789	Transcriptional regulator
IC778_RS20570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC778_RS20595	COG2132	Multicopper oxidase
IC778_RS20610	COG2205	protein histidine kinase activity
IC778_RS20620	COG2217	Heavy metal translocating P-type atpase
IC778_RS20710	COG0210	DNA helicase
IC778_RS20730	COG0210	DNA helicase
IC778_RS20775	COG0582	viral genome integration into host DNA
IC778_RS20790	COG2130	NADP-dependent
IC778_RS20795	COG1309	transcriptional regulator
IC778_RS20805	COG1902	pentaerythritol trinitrate reductase activity
IC778_RS20895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC778_RS20930	COG0741	lytic transglycosylase activity
IC778_RS21110	COG3853	Toxic anion resistance protein (TelA)
IC778_RS21125	COG1475	DNA binding
IC778_RS21210	COG1525	nuclease