locus-tag class description E5Y90_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E5Y90_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5Y90_RS00025 ENOG4105E2A Dehydrogenase E5Y90_RS00030 ENOG4105C5H ABC transporter E5Y90_RS00035 ENOG4108821 RND type efflux pump E5Y90_RS00040 ENOG4108821 RND type efflux pump E5Y90_RS00045 ENOG4108821 RND type efflux pump E5Y90_RS00050 ENOG4108YX9 iron--sulfur cluster insertion protein erpA E5Y90_RS00090 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E5Y90_RS00125 ENOG4105D2S major facilitator superfamily E5Y90_RS00130 ENOG4105D2S major facilitator superfamily E5Y90_RS00140 ENOG4107SNB ankyrin repeat protein YahD E5Y90_RS00145 ENOG4107RKG DJ-1/PfpI family E5Y90_RS00160 ENOG4105C8J )-transporter E5Y90_RS00170 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) E5Y90_RS00180 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E5Y90_RS00195 ENOG4105C01 Dihydroxy-acid dehydratase E5Y90_RS00220 ENOG4105C2W permease E5Y90_RS00235 ENOG4105DJY efflux transporter, rnd family, mfp subunit E5Y90_RS00285 ENOG4106BRA Membrane E5Y90_RS00300 ENOG4105D9M gamma-glutamylcysteine synthetase E5Y90_RS00305 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) E5Y90_RS00315 ENOG4105IPS esterase E5Y90_RS00320 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5Y90_RS00355 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E5Y90_RS00360 ENOG4105BZU Histidine kinase E5Y90_RS00365 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) E5Y90_RS00380 ENOG4105KUZ arsenate reductase E5Y90_RS00385 ENOG4105CGK Exodeoxyribonuclease III E5Y90_RS00395 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5Y90_RS00405 ENOG4108ZAI phosphatidylglycerophosphatase a E5Y90_RS00410 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E5Y90_RS00425 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E5Y90_RS00440 ENOG4105D05 Receptor E5Y90_RS00480 ENOG4106FTQ Taurine ABC transporter, periplasmic E5Y90_RS00485 ENOG4108IY8 ABC, transporter E5Y90_RS00490 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E5Y90_RS00500 ENOG4105DAA L-lactate E5Y90_RS00505 ENOG41073TP transcriptional regulator E5Y90_RS00515 ENOG4105CXG d-lactate dehydrogenase E5Y90_RS00560 ENOG4105C0D helicase E5Y90_RS00645 ENOG4107QKA exodeoxyribonuclease V beta E5Y90_RS00660 ENOG4105E5H Transposase E5Y90_RS00670 ENOG4105IYK transposase E5Y90_RS00685 ENOG4105EKQ RNA-directed DNA polymerase E5Y90_RS00700 ENOG41090BB DNA mismatch endonuclease (vsr) E5Y90_RS00705 ENOG4105DVF Cytosine-specific methyltransferase E5Y90_RS00745 ENOG4105ZTP Protein of unknown function (DUF1376) E5Y90_RS00790 ENOG4107QJE Chromosome Partitioning Protein E5Y90_RS00805 ENOG4105DQR SNARE associated Golgi E5Y90_RS00810 ENOG4105H4F exported protein E5Y90_RS00815 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E5Y90_RS00820 ENOG4105BZU Histidine kinase E5Y90_RS00825 ENOG4105EUB pirin domain protein E5Y90_RS00830 ENOG4108RXX maleylacetoacetate isomerase E5Y90_RS00835 ENOG4105BZU Histidine kinase E5Y90_RS00840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5Y90_RS00855 ENOG4107QJQ Mate efflux family protein E5Y90_RS00905 ENOG4105DFH Transport of potassium into the cell (By similarity) E5Y90_RS00940 ENOG4105CUV Homoserine Kinase E5Y90_RS00975 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E5Y90_RS01030 ENOG4105CHU acetyl-coa acetyltransferase E5Y90_RS01050 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein E5Y90_RS01065 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E5Y90_RS01080 ENOG4108HRK Histidine kinase E5Y90_RS01085 ENOG4108NEV two component transcriptional regulator, LytTR family E5Y90_RS01090 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) E5Y90_RS01115 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS E5Y90_RS01130 ENOG4105GVR general secretion pathway protein D E5Y90_RS01140 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E5Y90_RS01180 ENOG4105PM1 preprotein translocase subunit SecE E5Y90_RS01185 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E5Y90_RS01190 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) E5Y90_RS01195 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) E5Y90_RS01200 ENOG4108VZM 50s ribosomal protein L10 E5Y90_RS01210 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E5Y90_RS01240 ENOG4105D3Y Na H antiporter E5Y90_RS01255 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) E5Y90_RS01285 ENOG4107ZXU DSBA oxidoreductase E5Y90_RS01290 ENOG4105CYC Transferase E5Y90_RS01295 ENOG4105E0F Histidine kinase E5Y90_RS01320 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) E5Y90_RS01330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) E5Y90_RS01340 ENOG4105CSR polyphosphate kinase 2 E5Y90_RS01350 ENOG4105DSY exodeoxyribonuclease V, gamma E5Y90_RS01355 ENOG4107QKA exodeoxyribonuclease V beta E5Y90_RS01360 ENOG4107QYX exodeoxyribonuclease v alpha E5Y90_RS01370 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) E5Y90_RS01375 ENOG4107QUT magnesium and cobalt transport protein CorA E5Y90_RS01380 ENOG4105Z2P Protein of unknown function (DUF465) E5Y90_RS01385 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) E5Y90_RS01395 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) E5Y90_RS01405 ENOG4105C25 Primosomal protein n' E5Y90_RS01410 ENOG4105D7Q type ii secretion system E5Y90_RS01415 ENOG4108VAU general secretion pathway protein G E5Y90_RS01430 ENOG4108JU5 Magnesium and cobalt efflux protein E5Y90_RS01435 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) E5Y90_RS01440 ENOG4105CS6 Rhs element vgr protein E5Y90_RS01455 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5Y90_RS01465 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E5Y90_RS01480 ENOG4105C5X domain protein E5Y90_RS01485 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) E5Y90_RS01495 ENOG4105BZ8 glutamate synthase E5Y90_RS01505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E5Y90_RS01520 ENOG4105C5I Dehydrogenase E5Y90_RS01540 ENOG4105C38 Glycyl-tRNA synthetase beta subunit E5Y90_RS01555 ENOG4105C8P )-transporter E5Y90_RS01565 ENOG41067S9 phage shock protein C, PspC E5Y90_RS01590 ENOG4105J5T Amp-dependent synthetase and ligase E5Y90_RS01595 ENOG4105C03 ribonuclease E5Y90_RS01600 ENOG4105EI2 Pseudouridine synthase E5Y90_RS01605 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E5Y90_RS01610 ENOG4105IKQ hydratase E5Y90_RS01615 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) E5Y90_RS01620 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) E5Y90_RS01625 ENOG4105EPF Outer membrane porin E5Y90_RS01635 ENOG4105IYK transposase E5Y90_RS01645 ENOG4105E5H Transposase E5Y90_RS01650 ENOG4108W5M transcriptional regulator E5Y90_RS01655 ENOG4105FUY alpha subunit E5Y90_RS01670 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase E5Y90_RS01675 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) E5Y90_RS01680 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase E5Y90_RS01700 ENOG4105KIR Thiol-disulfide oxidoreductase dcc E5Y90_RS01705 ENOG4105CH6 catalase E5Y90_RS01710 ENOG4105CSU acyl-Coa dehydrogenase E5Y90_RS01720 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E5Y90_RS01745 ENOG4105DUM transcriptional regulator, lysR family E5Y90_RS01755 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5Y90_RS01770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E5Y90_RS01820 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E5Y90_RS01825 ENOG4105C5H ABC transporter E5Y90_RS01830 ENOG4105VRX Protein slyX homolog E5Y90_RS01850 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E5Y90_RS01865 ENOG4105BZW Glycerate kinase E5Y90_RS01875 ENOG4105VFU Rna-binding protein E5Y90_RS01890 ENOG4105CKD glutathione-regulated potassium-efflux system protein E5Y90_RS01905 ENOG4107RGH Aldehyde dehydrogenase E5Y90_RS01910 ENOG41062JF Transcriptional regulator E5Y90_RS01915 ENOG4105CIY formyltetrahydrofolate deformylase E5Y90_RS01955 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) E5Y90_RS01995 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) E5Y90_RS02010 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E5Y90_RS02025 ENOG4105DWV Homoserine O-trans-acetylase E5Y90_RS02030 ENOG4105DWV Homoserine O-trans-acetylase E5Y90_RS02035 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) E5Y90_RS02045 ENOG4108ESX Receptor E5Y90_RS02050 ENOG4105D05 Receptor E5Y90_RS02060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E5Y90_RS02075 ENOG4107GFK fumarate E5Y90_RS02085 ENOG4108FUF Transcriptional regulator, IclR family E5Y90_RS02090 ENOG4105C26 Dehydrogenase E5Y90_RS02095 ENOG4105C0A alcohol dehydrogenase E5Y90_RS02100 ENOG4105CY2 Citrate transporter E5Y90_RS02105 ENOG4108DNC Involved in acetate metabolism (By similarity) E5Y90_RS02110 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E5Y90_RS02135 ENOG4105CN1 protease E5Y90_RS02155 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5Y90_RS02160 ENOG4105W8H transhydrogenase (subunit alpha E5Y90_RS02165 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5Y90_RS02170 ENOG4105EMK carboxylate amino acid amine transporter E5Y90_RS02180 ENOG4105VKU nucleicacid-binding protein E5Y90_RS02185 ENOG4105DGW oligopeptidase A E5Y90_RS02195 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E5Y90_RS02230 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E5Y90_RS02235 ENOG4107S2Z UPF0761 membrane protein E5Y90_RS02240 ENOG4105CS1 NAD(P)H quinone oxidoreductase E5Y90_RS02280 ENOG4105C9A Phoh family E5Y90_RS02290 ENOG4105E4C Lytic transglycosylase catalytic E5Y90_RS02330 ENOG4105D6S protein involved in catabolism of external DNA E5Y90_RS02335 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase E5Y90_RS02400 ENOG4105NAU thioesterase Superfamily protein E5Y90_RS02430 ENOG4105K9H YciI-like protein E5Y90_RS02440 ENOG4105DB7 PHP domain protein E5Y90_RS02445 ENOG4105FFC UPF0187 protein E5Y90_RS02450 ENOG4105W5Q DNA repair protein (RadC E5Y90_RS02455 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E5Y90_RS02465 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5Y90_RS02470 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) E5Y90_RS02480 ENOG4108ZJ4 polysaccharide deacetylase E5Y90_RS02485 ENOG4105F8V Hydrolase, tatD family E5Y90_RS02490 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E5Y90_RS02500 ENOG4105VW4 glutaredoxin 3 E5Y90_RS02510 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E5Y90_RS02515 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E5Y90_RS02520 ENOG4105CUZ uba thif-type nad fad binding protein E5Y90_RS02530 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E5Y90_RS02535 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E5Y90_RS02540 ENOG4105DJY efflux transporter, rnd family, mfp subunit E5Y90_RS02550 ENOG4105IYK transposase E5Y90_RS02560 ENOG4105E5H Transposase E5Y90_RS02590 ENOG4105C7K acetolactate synthase E5Y90_RS02595 ENOG4108ZP8 Acetolactate synthase small subunit E5Y90_RS02635 ENOG4105WVQ Fe-S assembly protein IscX E5Y90_RS02650 ENOG4105CFV Tetratricopeptide repeat protein E5Y90_RS02655 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) E5Y90_RS02665 ENOG4105CUT histidyl-tRNA synthetase E5Y90_RS02675 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5Y90_RS02700 ENOG4105DXN mazG family E5Y90_RS02705 ENOG4105KQC Competence protein E5Y90_RS02710 ENOG4105DJ0 Poly(A) Polymerase E5Y90_RS02715 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E5Y90_RS02730 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) E5Y90_RS02735 ENOG41080Z8 PHOSPHOCARRIER protein E5Y90_RS02740 ENOG4105N42 UPF0307 protein E5Y90_RS02745 ENOG4105BZU Histidine kinase E5Y90_RS02750 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) E5Y90_RS02755 ENOG4105CM2 brancheD-chain amino acid aminotransferase E5Y90_RS02765 ENOG4105C6Y Udp-glucose 6-dehydrogenase E5Y90_RS02785 ENOG4107J0A lipopolysaccharide biosynthetic process E5Y90_RS02790 ENOG4105C1B dTDP-glucose 4-6-dehydratase E5Y90_RS02795 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E5Y90_RS02805 ENOG4108UT6 Transferase hexapeptide repeat containing protein E5Y90_RS02815 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E5Y90_RS02820 ENOG41090RK glycosyl transferase E5Y90_RS02845 ENOG4105C9M aspartyl-trna synthetase E5Y90_RS02855 ENOG4105UGU tonB-dependent Receptor E5Y90_RS02880 ENOG4105CSU acyl-Coa dehydrogenase E5Y90_RS02885 ENOG4105CSU acyl-Coa dehydrogenase E5Y90_RS02895 ENOG4105EB3 Histidine kinase E5Y90_RS02900 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5Y90_RS02910 ENOG4105CNG UPF0061 protein E5Y90_RS02925 ENOG4108WBT adenosyltransferase E5Y90_RS02930 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) E5Y90_RS02945 ENOG4105C2M dna polymerase I E5Y90_RS02965 ENOG4107QHF type ii secretion system protein e E5Y90_RS02970 ENOG4108ZHJ Organic hydroperoxide resistance protein E5Y90_RS02990 ENOG410903C (LipO)protein E5Y90_RS03040 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) E5Y90_RS03050 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E5Y90_RS03060 ENOG4105CRQ synthase (Component I) E5Y90_RS03100 ENOG4105P8F nudix hydrolase E5Y90_RS03110 ENOG41072GX Peptidase M22 Glycoprotease E5Y90_RS03115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) E5Y90_RS03130 ENOG4105C4W S-formylglutathione hydrolase E5Y90_RS03145 ENOG4105DJV ribulose-phosphate 3-epimerase E5Y90_RS03180 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E5Y90_RS03200 ENOG4108EKN Biotin protein ligase C terminal domain E5Y90_RS03205 ENOG4105HF0 Membrane E5Y90_RS03215 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E5Y90_RS03225 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) E5Y90_RS03235 ENOG4108UWD Iron-storage protein E5Y90_RS03275 ENOG4105FE9 pseudouridine synthase E5Y90_RS03280 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) E5Y90_RS03285 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) E5Y90_RS03295 ENOG4107RTD sua5 ycio yrdc ywlc family protein E5Y90_RS03300 ENOG4108BPE -transporting atpase E5Y90_RS03305 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E5Y90_RS03315 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E5Y90_RS03320 ENOG4105CHR reductase E5Y90_RS03325 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E5Y90_RS03330 ENOG4109066 lysm domain bon superfamily protein E5Y90_RS03335 ENOG4105EW9 transcriptional regulator AsnC family E5Y90_RS03350 ENOG4105M4H endoribonuclease L-psp E5Y90_RS03360 ENOG4108YXA Membrane E5Y90_RS03375 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) E5Y90_RS03400 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E5Y90_RS03415 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) E5Y90_RS03420 ENOG4105C3M thioredoxin reductase E5Y90_RS03425 ENOG4105CNU cell division protein FtsK E5Y90_RS03440 ENOG4107QMS site-determining protein E5Y90_RS03445 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) E5Y90_RS03455 ENOG4106HNH Acyl-transferase E5Y90_RS03460 ENOG4108ZG0 Ompa motb domain protein E5Y90_RS03465 ENOG4105C4R Atp-dependent dna helicase E5Y90_RS03470 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) E5Y90_RS03490 ENOG4107QKV phosphomannomutase E5Y90_RS03495 ENOG4105CAS nag kinase E5Y90_RS03500 ENOG4105E7A Glutamine amidotransferase E5Y90_RS03530 ENOG41090R7 Ferric uptake E5Y90_RS03535 ENOG4105CZX twitching motility protein E5Y90_RS03540 ENOG4105CZX twitching motility protein E5Y90_RS03545 ENOG4105DFA alanine racemase domain protein E5Y90_RS03555 ENOG4105EYH Exonuclease E5Y90_RS03560 ENOG4107RH8 nuclease SbcCD subunit D E5Y90_RS03570 ENOG4105ECP epimerase E5Y90_RS03575 ENOG4108DN8 FAD dependent oxidoreductase E5Y90_RS03580 ENOG4105D52 delta-aminolevulinic acid dehydratase E5Y90_RS03585 ENOG4108VUY thioesterase Superfamily protein E5Y90_RS03590 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) E5Y90_RS03620 ENOG4105G6Z alkaline phosphatase E5Y90_RS03625 ENOG4105G6Z alkaline phosphatase E5Y90_RS03635 ENOG4108ZX5 transcriptional regulator E5Y90_RS03655 ENOG4105E02 MotA TolQ exbB proton channel E5Y90_RS03660 ENOG4105M8F Biopolymer transport protein exbD tolR E5Y90_RS03715 ENOG4105WPN DNA integration recombination invertion protein E5Y90_RS03720 ENOG4105CSH Transporter E5Y90_RS03730 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) E5Y90_RS03735 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) E5Y90_RS03740 ENOG4105HF0 Membrane E5Y90_RS03745 ENOG4105DZ2 Transcriptional regulator E5Y90_RS03760 ENOG4105CF7 AraC family transcriptional regulator E5Y90_RS03765 ENOG4105D2S major facilitator superfamily E5Y90_RS03780 ENOG4105F57 Anthranilate dioxygenase reductase E5Y90_RS03785 ENOG4108YS2 small subunit E5Y90_RS03790 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit E5Y90_RS03820 ENOG4105CNM Receptor E5Y90_RS03835 ENOG4105EJC lysr family transcriptional regulator E5Y90_RS03840 ENOG4105C94 Transporter E5Y90_RS03845 ENOG4105F2M alpha beta hydrolase fold-3 domain protein E5Y90_RS03850 ENOG4105DVW rieske (2Fe-2S) E5Y90_RS03860 ENOG4105E3J oxidoreductase E5Y90_RS03870 ENOG4107R1I NAD-dependent malic enzyme E5Y90_RS03890 ENOG4105EUV Phenol 2-monooxygenase E5Y90_RS03910 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein E5Y90_RS03925 ENOG41080HT Transcriptional regulator, arsr family E5Y90_RS03975 ENOG4106UW1 Major Facilitator superfamily E5Y90_RS03980 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase E5Y90_RS03985 ENOG4108K4C ec 3.1.3.12 E5Y90_RS04040 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E5Y90_RS04050 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E5Y90_RS04060 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E5Y90_RS04065 ENOG4105VQ7 Rod shape-determining protein MreD E5Y90_RS04070 ENOG4108Z03 MAF-like protein E5Y90_RS04075 ENOG4105C03 ribonuclease E5Y90_RS04085 ENOG4105D8T Acyltransferase E5Y90_RS04095 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein E5Y90_RS04115 ENOG4105C85 amino acid E5Y90_RS04120 ENOG4107R11 Transcriptional regulator E5Y90_RS04125 ENOG4108IJ6 ABC transporter E5Y90_RS04130 ENOG4105ECW sulfate abc transporter E5Y90_RS04135 ENOG4108I5D sulfate abc transporter E5Y90_RS04145 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E5Y90_RS04155 ENOG4105HHA aminodeoxychorismate lyase E5Y90_RS04170 ENOG4108IYU L-aspartate oxidase E5Y90_RS04175 ENOG4105C0H protease E5Y90_RS04190 ENOG4105C3F Signal peptidase i E5Y90_RS04200 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) E5Y90_RS04205 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) E5Y90_RS04215 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) E5Y90_RS04220 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E5Y90_RS04225 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E5Y90_RS04255 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E5Y90_RS04260 ENOG4105CE9 30S ribosomal protein S2 E5Y90_RS04280 ENOG4105CVE Lytic murein transglycosylase E5Y90_RS04295 ENOG4105E3A (ABC) transporter E5Y90_RS04300 ENOG4105DA5 (ABC) transporter E5Y90_RS04315 ENOG4107VXM glycerophosphoryl diester phosphodiesterase E5Y90_RS04325 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E5Y90_RS04370 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E5Y90_RS04375 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E5Y90_RS04385 ENOG4105E33 succinate dehydrogenase E5Y90_RS04390 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E5Y90_RS04395 ENOG4105C7S Dehydrogenase E5Y90_RS04400 ENOG4107QN2 dihydrolipoyl dehydrogenase E5Y90_RS04410 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E5Y90_RS04425 ENOG4107BJW polysaccharide deacetylase E5Y90_RS04445 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) E5Y90_RS04455 ENOG4105DHQ Histidine kinase E5Y90_RS04465 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E5Y90_RS04475 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase E5Y90_RS04500 ENOG4105DZ2 Transcriptional regulator E5Y90_RS04565 ENOG4108JU3 Alkyl hydroperoxide reductase E5Y90_RS04570 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E5Y90_RS04575 ENOG4105CFP Peptidase U32 E5Y90_RS04580 ENOG4108Z6Z Transcriptional regulator E5Y90_RS04590 ENOG4105DP0 ferredoxin-NADP reductase E5Y90_RS04595 ENOG4108R96 Methyltransferase, YaeB family E5Y90_RS04605 ENOG4107QHF type ii secretion system protein e E5Y90_RS04615 ENOG4105XJC Two component transcriptional regulator (Winged helix family E5Y90_RS04620 ENOG4105DHQ Histidine kinase E5Y90_RS04630 ENOG4105M6F mutator MutT protein E5Y90_RS04640 ENOG4105BZ4 penicillin-binding protein E5Y90_RS04645 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) E5Y90_RS04650 ENOG4105VUT cytoplasmic protein E5Y90_RS04660 ENOG4105CK2 sodium dicarboxylate symporter E5Y90_RS04665 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS04670 ENOG4107R7Y intracellular protease Pfpi family E5Y90_RS04680 ENOG4105CIH Imidazole acetol-phosphate transaminase E5Y90_RS04685 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E5Y90_RS04710 ENOG4105C7N Xanthine uracil vitamin C permease E5Y90_RS04715 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E5Y90_RS04730 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E5Y90_RS04740 ENOG4105CFH Aspartokinase E5Y90_RS04750 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E5Y90_RS04765 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E5Y90_RS04780 ENOG4108YZY peptidylprolyl cis-trans isomerase E5Y90_RS04785 ENOG4105DZ1 carboxypeptidase E5Y90_RS04800 ENOG4108UHE carbonic anhydrase E5Y90_RS04805 ENOG4107ZQV short-chain dehydrogenase reductase E5Y90_RS04815 ENOG4105HSS phospholipase C E5Y90_RS04825 ENOG4105IYK transposase E5Y90_RS04835 ENOG4105E5H Transposase E5Y90_RS04845 ENOG4108R99 pseudouridine synthase E5Y90_RS04850 ENOG4107VXM glycerophosphoryl diester phosphodiesterase E5Y90_RS04880 ENOG4105CHM Aminotransferase E5Y90_RS04885 ENOG4105E0X reductase E5Y90_RS04890 ENOG4108V06 Glutathione peroxidase E5Y90_RS04895 ENOG4105CHM Aminotransferase E5Y90_RS04900 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) E5Y90_RS04910 ENOG4105ZED uncharacterized protein ygaH E5Y90_RS04915 ENOG4108UMN azlc family E5Y90_RS04935 ENOG4105NX3 Membrane E5Y90_RS04950 ENOG4105BZU Histidine kinase E5Y90_RS04965 ENOG4105EUJ GTP cyclohydrolase i E5Y90_RS04980 ENOG4107QYG anthranilate phosphoribosyltransferase E5Y90_RS04985 ENOG4105DDQ anthranilate synthase E5Y90_RS05005 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) E5Y90_RS05050 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5Y90_RS05055 ENOG4107QNR UPF0135 protein E5Y90_RS05060 ENOG4105C0H protease E5Y90_RS05085 ENOG4107QPN acyl-Coa dehydrogenase E5Y90_RS05090 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E5Y90_RS05095 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) E5Y90_RS05125 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E5Y90_RS05135 ENOG4105DTR rard protein E5Y90_RS05165 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E5Y90_RS05170 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E5Y90_RS05185 ENOG4105CCF Lysine exporter protein (Lyse ygga) E5Y90_RS05200 ENOG4108JU3 Alkyl hydroperoxide reductase E5Y90_RS05215 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E5Y90_RS05220 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E5Y90_RS05225 ENOG4105EHM Aminoglycoside phosphotransferase E5Y90_RS05230 ENOG4108S0S Nucleotidyl transferase E5Y90_RS05240 ENOG4107QJE Chromosome Partitioning Protein E5Y90_RS05245 ENOG4105FA0 parb-like partition protein E5Y90_RS05260 ENOG4105BZ1 (ABC) transporter E5Y90_RS05265 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) E5Y90_RS05275 ENOG4107QRG dna polymerase iii E5Y90_RS05285 ENOG4105F8V Hydrolase, tatD family E5Y90_RS05290 ENOG4105R8C Transcriptional regulator E5Y90_RS05310 ENOG4108RTD type II secretion system protein K E5Y90_RS05320 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) E5Y90_RS05330 ENOG4108Z6B deaminase E5Y90_RS05345 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E5Y90_RS05350 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E5Y90_RS05365 ENOG4105DWU Membrane E5Y90_RS05370 ENOG4107RN6 Monooxygenase E5Y90_RS05380 ENOG4105D6Z AFG1 family ATPase E5Y90_RS05385 ENOG4107QP3 malate synthase g E5Y90_RS05405 ENOG4105EE5 Membrane protein terC E5Y90_RS05420 ENOG4105CD8 aminopeptidase N E5Y90_RS05430 ENOG41081QV Universal stress protein E5Y90_RS05445 ENOG4105DKK Benzoate E5Y90_RS05450 ENOG4108NIW Leucine export protein LeuE E5Y90_RS05455 ENOG4107QV2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E5Y90_RS05460 ENOG4105HEI LysR family (Transcriptional regulator E5Y90_RS05475 ENOG4105CHU acetyl-coa acetyltransferase E5Y90_RS05480 ENOG4105CHR reductase E5Y90_RS05495 ENOG4105IYK transposase E5Y90_RS05505 ENOG4105E5H Transposase E5Y90_RS05510 ENOG4105CAU Arsenical resistance protein, ArsH E5Y90_RS05515 ENOG4105D6J arsenicaL-resistance protein E5Y90_RS05520 ENOG41082YX Transcriptional regulator, arsr family E5Y90_RS05540 ENOG4105D3G Pseudouridine synthase E5Y90_RS05545 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E5Y90_RS05560 ENOG4105EJ2 Transcriptional regulator E5Y90_RS05590 ENOG4107QIJ Aconitate hydratase 2 E5Y90_RS05605 ENOG4105EW9 transcriptional regulator AsnC family E5Y90_RS05625 ENOG4105CWM branched-chain amino acid transport system II carrier protein E5Y90_RS05630 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E5Y90_RS05635 ENOG4105CC0 LysR family Transcriptional regulator E5Y90_RS05640 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E5Y90_RS05655 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5Y90_RS05685 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) E5Y90_RS05690 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E5Y90_RS05700 ENOG4105CNI cell division protein FtsW E5Y90_RS05715 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5Y90_RS05720 ENOG4105C4M (Ubiquinol oxidase) subunit I E5Y90_RS05735 ENOG4107QNJ CoA-transferase subunit B E5Y90_RS05745 ENOG4108M0I Transcriptional regulator E5Y90_RS05750 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E5Y90_RS05790 ENOG4105C0B DNA polymerase III (alpha subunit) E5Y90_RS05795 ENOG4108UMI ABC transporter, permease E5Y90_RS05800 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5Y90_RS05810 ENOG4105C12 Phosphoribosylglycinamide synthetase E5Y90_RS05815 ENOG4105DC1 bifunctional purine biosynthesis protein purh E5Y90_RS05820 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) E5Y90_RS05855 ENOG4108SC4 )-transporter E5Y90_RS05865 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5Y90_RS05870 ENOG4105CUX Signal transduction histidine kinase E5Y90_RS05890 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E5Y90_RS05895 ENOG4105KNE Phosphatidate cytidylyltransferase E5Y90_RS05905 ENOG4105DZP Membrane-associated zinc metalloprotease E5Y90_RS05910 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5Y90_RS05920 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5Y90_RS05925 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) E5Y90_RS05930 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5Y90_RS05945 ENOG4105Y3E Modulates RecA activity (By similarity) E5Y90_RS05950 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) E5Y90_RS05955 ENOG4105VEJ Heat shock protein E5Y90_RS05960 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E5Y90_RS05965 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E5Y90_RS05980 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) E5Y90_RS05985 ENOG4105K4T epimerase E5Y90_RS05990 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) E5Y90_RS06000 ENOG4105EZE Cupin 4 family protein E5Y90_RS06010 ENOG4108UHJ MAF-like protein E5Y90_RS06020 ENOG4105BZA Phosphoglycerate kinase E5Y90_RS06030 ENOG4105D2N Aldolase E5Y90_RS06035 ENOG4108TZV Membrane E5Y90_RS06045 ENOG4108RCM Nitroreductase E5Y90_RS06055 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) E5Y90_RS06065 ENOG4105CX6 glutaminyL-tRNA synthetase E5Y90_RS06070 ENOG4105FFC UPF0187 protein E5Y90_RS06085 ENOG4108JJ7 ABC transporter E5Y90_RS06095 ENOG4107QMP dna polymerase iii subunits gamma and tau E5Y90_RS06105 ENOG4105C0A alcohol dehydrogenase E5Y90_RS06110 ENOG4105KJF protein tyrosine phosphatase E5Y90_RS06130 ENOG4105CBC glutamate synthase E5Y90_RS06155 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E5Y90_RS06160 ENOG4105CDU Replicative dna helicase E5Y90_RS06185 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E5Y90_RS06190 ENOG4105CCU oxidase (Subunit III) E5Y90_RS06195 ENOG4105BZ9 Cytochrome C oxidase, subunit I E5Y90_RS06200 ENOG4105E2S oxidase) subunit II E5Y90_RS06225 ENOG4105DEN Luciferase family E5Y90_RS06240 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) E5Y90_RS06245 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E5Y90_RS06265 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS06285 ENOG4105D06 uba thif-type nad fad binding protein E5Y90_RS06310 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) E5Y90_RS06315 ENOG4105CFU surface antigen E5Y90_RS06350 ENOG4107QS8 (LipO)protein E5Y90_RS06400 ENOG4105NI8 Cytosine-specific methyltransferase E5Y90_RS06645 ENOG4105NVB glycoside hydrolase, family 19 E5Y90_RS06665 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5Y90_RS06685 ENOG41066VF YeeE YedE family protein E5Y90_RS06700 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP E5Y90_RS06710 ENOG4105F9F transposase E5Y90_RS06715 ENOG4105CV1 Transketolase (EC 2.2.1.1) E5Y90_RS06725 ENOG4108YYC ycei family E5Y90_RS06735 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E5Y90_RS06740 ENOG4108SHQ Glutathione S-transferase E5Y90_RS06760 ENOG4105C2X Arabinose 5-phosphate isomerase E5Y90_RS06775 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E5Y90_RS06780 ENOG4108IUZ ABC transporter E5Y90_RS06785 ENOG4105DFG type I secretion outer membrane protein E5Y90_RS06825 ENOG4108Z4U Ferredoxin E5Y90_RS06835 ENOG4105K59 histidine triad (HIT) protein E5Y90_RS06845 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5Y90_RS06855 ENOG4105C28 cystathionine E5Y90_RS06865 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) E5Y90_RS06895 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E5Y90_RS06900 ENOG41080XP Cbs domain E5Y90_RS06935 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E5Y90_RS06950 ENOG41068P6 UPF0319 protein E5Y90_RS06985 ENOG4107SC1 transglycosylase E5Y90_RS06990 ENOG4108MJ3 acetyltransferase E5Y90_RS06995 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS07020 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E5Y90_RS07060 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5Y90_RS07065 ENOG4107TSN permease E5Y90_RS07070 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5Y90_RS07075 ENOG4105E7U AraC family transcriptional regulator E5Y90_RS07080 ENOG4105EEF Alkane 1-monooxygenase E5Y90_RS07085 ENOG4105CSU acyl-Coa dehydrogenase E5Y90_RS07105 ENOG4105C4M (Ubiquinol oxidase) subunit I E5Y90_RS07110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5Y90_RS07120 ENOG4105KK6 nuclease E5Y90_RS07125 ENOG41064T2 transcriptional regulator, lysR family E5Y90_RS07130 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS07165 ENOG4107RZC phospholipase d E5Y90_RS07180 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5Y90_RS07185 ENOG4105CZM Major Facilitator E5Y90_RS07195 ENOG4108R6W Transcriptional regulator, ARAC family E5Y90_RS07200 ENOG4105BZ1 (ABC) transporter E5Y90_RS07205 ENOG4105CUY Mechanosensitive ion channel E5Y90_RS07210 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E5Y90_RS07230 ENOG41080HT Transcriptional regulator, arsr family E5Y90_RS07235 ENOG4105C6T cysteine synthase E5Y90_RS07255 ENOG41062JF Transcriptional regulator E5Y90_RS07260 ENOG4105CSU acyl-Coa dehydrogenase E5Y90_RS07265 ENOG4105CHU acetyl-coa acetyltransferase E5Y90_RS07270 ENOG4105CYC Transferase E5Y90_RS07285 ENOG4105F2Z 3-oxoadipate enol-lactonase E5Y90_RS07290 ENOG4105CHU acetyl-coa acetyltransferase E5Y90_RS07295 ENOG4107QNJ CoA-transferase subunit B E5Y90_RS07300 ENOG4107QP7 CoA-transferase subunit A E5Y90_RS07305 ENOG4105DKK Benzoate E5Y90_RS07310 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase E5Y90_RS07315 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein E5Y90_RS07320 ENOG4108UKV benzoate 1,2-dioxygenase E5Y90_RS07325 ENOG4105FUY alpha subunit E5Y90_RS07335 ENOG4105NN7 muconolactone delta-isomerase E5Y90_RS07340 ENOG4105DTQ mandelate racemase muconate lactonizing E5Y90_RS07345 ENOG4108KB2 LysR family Transcriptional regulator E5Y90_RS07350 ENOG4105D2S major facilitator superfamily E5Y90_RS07360 ENOG4105CEY Amp-dependent synthetase and ligase E5Y90_RS07365 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E5Y90_RS07375 ENOG4107YBY Hydrolase E5Y90_RS07380 ENOG4108PTX LysR family Transcriptional regulator E5Y90_RS07385 ENOG4105DDY UPF0142 protein ycaO E5Y90_RS07390 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5Y90_RS07410 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E5Y90_RS07425 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E5Y90_RS07430 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E5Y90_RS07445 ENOG4107RR1 TRANSCRIPTIONal E5Y90_RS07450 ENOG4105C0A alcohol dehydrogenase E5Y90_RS07460 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) E5Y90_RS07465 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) E5Y90_RS07475 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E5Y90_RS07480 ENOG4107R0V Pyruvate dehydrogenase E5Y90_RS07485 ENOG4105CPP Dehydrogenase, E1 component E5Y90_RS07490 ENOG4105C7S Dehydrogenase E5Y90_RS07535 ENOG4105EV9 Alpha Beta Hydrolase E5Y90_RS07560 ENOG4105CMR udp-glucose 4-epimerase E5Y90_RS07565 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) E5Y90_RS07595 ENOG4108Z66 YbaK ebsC protein E5Y90_RS07605 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E5Y90_RS07610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E5Y90_RS07625 ENOG4105D8G Major Facilitator superfamily E5Y90_RS07675 ENOG410620I Diguanylate cyclase E5Y90_RS07695 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) E5Y90_RS07725 ENOG4105BZN citrate synthase E5Y90_RS07730 ENOG4105CR4 methylisocitrate lyase E5Y90_RS07755 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5Y90_RS07760 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) E5Y90_RS07770 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase E5Y90_RS07785 ENOG4105E66 phosphoriboisomerase A E5Y90_RS07790 ENOG4105C7B Threonine dehydratase E5Y90_RS07800 ENOG4105CZN Potassium uptake protein E5Y90_RS07805 ENOG4105HDD phospholipase E5Y90_RS07830 ENOG4105PV3 Inner membrane protein yqiJ E5Y90_RS07850 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) E5Y90_RS07855 ENOG4105K70 DNA-binding protein E5Y90_RS07870 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family E5Y90_RS07880 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E5Y90_RS07885 ENOG4108Z4V iron-sulfur cluster assembly E5Y90_RS07900 ENOG4108ZIT Ferredoxin, 2FE-2S E5Y90_RS07905 ENOG4105F8J Adenylate Guanylate cyclase E5Y90_RS07915 ENOG4108JA2 transcriptioN-repair coupling factor E5Y90_RS07925 ENOG4108IJ0 Aspartate ammonia-lyase E5Y90_RS07960 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E5Y90_RS07975 ENOG4105I7R Adenylate cyclase E5Y90_RS08005 ENOG4105JAB phenazine biosynthesis protein, phzf family E5Y90_RS08010 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E5Y90_RS08065 ENOG4106PBJ Serine threonine-protein kinase Pkn6 E5Y90_RS08080 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) E5Y90_RS08085 ENOG4105CSH Transporter E5Y90_RS08090 ENOG4105EW9 transcriptional regulator AsnC family E5Y90_RS08105 ENOG4105KTH gatB Yqey E5Y90_RS08115 ENOG4105ERG peptidase m48, ste24p E5Y90_RS08120 ENOG4105C5I Dehydrogenase E5Y90_RS08135 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E5Y90_RS08170 ENOG41069NU Nitroreductase E5Y90_RS08180 ENOG4105C1J atp-dependent rna helicase E5Y90_RS08195 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5Y90_RS08200 ENOG4105M08 Membrane E5Y90_RS08225 ENOG4108K3A Glutathione S-transferase E5Y90_RS08230 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) E5Y90_RS08250 ENOG4105CEY Amp-dependent synthetase and ligase E5Y90_RS08255 ENOG4108SGK Tetr family transcriptional regulator E5Y90_RS08260 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS08265 ENOG4107QX3 carboxylase E5Y90_RS08270 ENOG4105E39 Enoyl-CoA hydratase E5Y90_RS08290 ENOG4107QNJ CoA-transferase subunit B E5Y90_RS08295 ENOG4105CRW Short chain fatty acid transporter E5Y90_RS08305 ENOG4105CD3 dihydroorotase E5Y90_RS08310 ENOG4105CXT aspartate transcarbamylase E5Y90_RS08320 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5Y90_RS08325 ENOG4105CPC Aldo Keto reductase E5Y90_RS08330 ENOG4107RYR Transcriptional regulator, Crp Fnr family E5Y90_RS08335 ENOG4108UKZ OsmC family E5Y90_RS08340 ENOG4107S1Q Phosphatase E5Y90_RS08345 ENOG4105E9K Isocitrate dehydrogenase E5Y90_RS08355 ENOG4105F8C transglutaminase domain-containing protein E5Y90_RS08365 ENOG4105C7R Atpase associated with various cellular activities aaa_3 E5Y90_RS08375 ENOG4105D22 carbon starvation protein E5Y90_RS08380 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E5Y90_RS08385 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E5Y90_RS08405 ENOG4105DHU Bile acid E5Y90_RS08420 ENOG4105DAN ATP-dependent protease E5Y90_RS08425 ENOG4105M2J Glutaredoxin E5Y90_RS08430 ENOG4105C8Y Acetylornithine aminotransferase E5Y90_RS08440 ENOG4105CR8 Transcriptional regulator E5Y90_RS08445 ENOG4108K5P (LipO)protein E5Y90_RS08450 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) E5Y90_RS08465 ENOG4105DZ1 carboxypeptidase E5Y90_RS08470 ENOG4108Z0R Transferase E5Y90_RS08480 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E5Y90_RS08490 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E5Y90_RS08495 ENOG4105K8N protein family UPF0079, ATPase E5Y90_RS08515 ENOG4105I08 Pseudouridine synthase E5Y90_RS08520 ENOG4108VMM UPF0756 membrane protein E5Y90_RS08525 ENOG4105EYW Ion transport protein E5Y90_RS08530 ENOG4107QUV Domain protein E5Y90_RS08545 ENOG4105CQ7 ATP-dependent helicase E5Y90_RS08550 ENOG4105D3R alkyl hydroperoxide reductase E5Y90_RS08575 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) E5Y90_RS08580 ENOG41075W9 High frequency lysogenization protein HflD homolog E5Y90_RS08585 ENOG4107QTF adenylosuccinate lyase E5Y90_RS08600 ENOG4105ERU peptidase E5Y90_RS08610 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E5Y90_RS08620 ENOG4105C8U phosphate abc transporter E5Y90_RS08625 ENOG4105CVA phosphate E5Y90_RS08630 ENOG4105DY8 decarboxylase E5Y90_RS08635 ENOG4108JPW Aminotransferase E5Y90_RS08710 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) E5Y90_RS08720 ENOG4105KVH Transcriptional regulator E5Y90_RS08740 ENOG4105E5H Transposase E5Y90_RS08750 ENOG4105IYK transposase E5Y90_RS08760 ENOG4105E39 Enoyl-CoA hydratase E5Y90_RS08765 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS08775 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5Y90_RS08780 ENOG4105C26 Dehydrogenase E5Y90_RS08785 ENOG4107YNJ LysR family Transcriptional regulator E5Y90_RS08790 ENOG41067CV Integrase E5Y90_RS08805 ENOG410626B catechol 1,2-dioxygenase E5Y90_RS08810 ENOG4108MR5 E5Y90_RS08815 ENOG4108MZY E5Y90_RS08820 ENOG4108KB2 LysR family Transcriptional regulator E5Y90_RS08825 ENOG4105DTQ mandelate racemase muconate lactonizing E5Y90_RS08830 ENOG4105NN7 muconolactone delta-isomerase E5Y90_RS08835 ENOG4107QP7 CoA-transferase subunit A E5Y90_RS08840 ENOG4107QNJ CoA-transferase subunit B E5Y90_RS08905 ENOG4105FUY alpha subunit E5Y90_RS08910 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) E5Y90_RS08935 ENOG4105E5H Transposase E5Y90_RS08945 ENOG4105IYK transposase E5Y90_RS09000 ENOG4105C3G gtp-binding protein E5Y90_RS09005 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5Y90_RS09010 ENOG4105C2I pirin domain protein E5Y90_RS09020 ENOG4105M6W Crispr-associated protein, Csy3 family E5Y90_RS09030 ENOG4105ENG CRISPR-associated protein, Csy1 family E5Y90_RS09040 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) E5Y90_RS09050 ENOG4105F95 Monooxygenase E5Y90_RS09065 ENOG4108KAZ Involved in phosphonate degradation (By similarity) E5Y90_RS09080 ENOG4107RCV ABC transporter, permease E5Y90_RS09085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E5Y90_RS09090 ENOG4105C4Y ABC transporter E5Y90_RS09105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5Y90_RS09125 ENOG4105EKE dihydroorotase E5Y90_RS09130 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) E5Y90_RS09145 ENOG4108IQI permease E5Y90_RS09155 ENOG4108IQI permease E5Y90_RS09190 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E5Y90_RS09195 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E5Y90_RS09200 ENOG4105E43 Extracellular solute-binding protein, family 5 E5Y90_RS09205 ENOG4105E9H Lytic Murein transglycosylase E5Y90_RS09210 ENOG4107RZZ dna polymerase iii epsilon subunit E5Y90_RS09220 ENOG4105E09 nadh pyrophosphatase E5Y90_RS09230 ENOG4105W4M Transport-associated protein E5Y90_RS09240 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) E5Y90_RS09245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E5Y90_RS09255 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E5Y90_RS09260 ENOG4105D0A hydroxylase E5Y90_RS09265 ENOG4105WG9 Conserved Protein E5Y90_RS09270 ENOG4107RAQ aminopeptidase E5Y90_RS09295 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E5Y90_RS09305 ENOG4107VAM peptidase, m28 E5Y90_RS09310 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) E5Y90_RS09315 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E5Y90_RS09330 ENOG4105D82 Glutamate dehydrogenase E5Y90_RS09335 ENOG4108R3D Electron transport complex E5Y90_RS09340 ENOG4105CSM endonuclease III E5Y90_RS09365 ENOG4105CJN penicillin-binding protein E5Y90_RS09370 ENOG4106H78 methyltransferase E5Y90_RS09380 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E5Y90_RS09390 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase E5Y90_RS09430 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E5Y90_RS09445 ENOG4105C4K Nad synthetase E5Y90_RS09460 ENOG4107YZX Universal stress protein E5Y90_RS09470 ENOG4105EEQ Na H antiporter E5Y90_RS09480 ENOG4105CGZ zinc metallopeptidase E5Y90_RS09485 ENOG4105CKW Inner membrane protein yedI E5Y90_RS09505 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) E5Y90_RS09510 ENOG4105VCQ rubredoxin E5Y90_RS09515 ENOG4107QZF nitrite reductase NADPH large subunit E5Y90_RS09525 ENOG4105C5Q Transcriptional regulator E5Y90_RS09540 ENOG4107U91 Rhomboid family E5Y90_RS09545 ENOG4105CV6 ABC transporter, permease E5Y90_RS09550 ENOG4108I0Y (ABC) transporter E5Y90_RS09555 ENOG4108UJV acyl-CoA thioesterase i E5Y90_RS09590 ENOG4105CJ3 phosphate transporter E5Y90_RS09595 ENOG4105C3R Methionine synthase E5Y90_RS09610 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E5Y90_RS09645 ENOG4107VMU Membrane E5Y90_RS09665 ENOG4105D78 K07001 NTE family protein E5Y90_RS09680 ENOG4105CK7 Sodium proline symporter E5Y90_RS09685 ENOG4105CTB Polyprenyl synthetase E5Y90_RS09690 ENOG4105C7F AcnD-accessory protein PrpF E5Y90_RS09700 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) E5Y90_RS09705 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E5Y90_RS09710 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) E5Y90_RS09720 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E5Y90_RS09735 ENOG4108YYC ycei family E5Y90_RS09745 ENOG4108IPT Naphthoate synthase E5Y90_RS09760 ENOG4108ETH Formylglycinamide ribotide synthetase E5Y90_RS09780 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) E5Y90_RS09785 ENOG4107YD3 Thioesterase E5Y90_RS09790 ENOG4105E02 MotA TolQ exbB proton channel E5Y90_RS09795 ENOG4105M8F Biopolymer transport protein exbD tolR E5Y90_RS09805 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) E5Y90_RS09810 ENOG4105KCK Peptidoglycan-associated lipoprotein E5Y90_RS09855 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) E5Y90_RS09860 ENOG4105C02 permease E5Y90_RS09870 ENOG4108V3E phosphoribosylglycinamide formyltransferase E5Y90_RS09885 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E5Y90_RS09890 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 E5Y90_RS09895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E5Y90_RS09915 ENOG4108UPT UPF0178 protein E5Y90_RS09955 ENOG4107KET secretion protein, HlyD family E5Y90_RS09975 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5Y90_RS09985 ENOG4105C10 Electron transfer flavoprotein E5Y90_RS09990 ENOG4105BZJ Electron transfer flavoprotein E5Y90_RS10005 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5Y90_RS10010 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) E5Y90_RS10020 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E5Y90_RS10030 ENOG4105C85 amino acid E5Y90_RS10035 ENOG4105BZG amino acid carrier protein E5Y90_RS10040 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E5Y90_RS10050 ENOG41082ND Uncharacterized protein yjcO E5Y90_RS10055 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) E5Y90_RS10060 ENOG4105SYT Methylenetetrahydrofolate reductase E5Y90_RS10065 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E5Y90_RS10075 ENOG4105C6K Malic enzyme E5Y90_RS10085 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) E5Y90_RS10095 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F E5Y90_RS10100 ENOG4107RGD Major Facilitator superfamily E5Y90_RS10105 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS10110 ENOG4105ETT transcriptional Regulator, LysR family E5Y90_RS10125 ENOG4108RRZ Transcription elongation factor GreB E5Y90_RS10140 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) E5Y90_RS10145 ENOG4105E4C Lytic transglycosylase catalytic E5Y90_RS10150 ENOG4105D0M Protease HtpX homolog E5Y90_RS10160 ENOG4105CJW magnesium transporter E5Y90_RS10165 ENOG4105BZS acriflavin resistance protein E5Y90_RS10170 ENOG4107RET Isocitrate lyase E5Y90_RS10180 ENOG4105C37 (CBS) domain E5Y90_RS10215 ENOG4105EEI dihydropteroate synthase E5Y90_RS10225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E5Y90_RS10230 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) E5Y90_RS10235 ENOG4105HBR Rna-binding protein E5Y90_RS10250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E5Y90_RS10255 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E5Y90_RS10265 ENOG4105CVP deoxyribo-dipyrimidine photolyase E5Y90_RS10270 ENOG4105EQK -acetyltransferase E5Y90_RS10290 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E5Y90_RS10310 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E5Y90_RS10315 ENOG4105C34 Pseudouridine synthase E5Y90_RS10320 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5Y90_RS10325 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E5Y90_RS10340 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) E5Y90_RS10370 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E5Y90_RS10375 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) E5Y90_RS10420 ENOG4107T5V SNARE associated Golgi E5Y90_RS10440 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5Y90_RS10445 ENOG41084BA UPF0250 protein E5Y90_RS10450 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E5Y90_RS10465 ENOG4105CUB amino acid E5Y90_RS10475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E5Y90_RS10480 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E5Y90_RS10485 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) E5Y90_RS10500 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) E5Y90_RS10510 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) E5Y90_RS10525 ENOG410841Q phosphoesterase PA-phosphatase related protein E5Y90_RS10530 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5Y90_RS10535 ENOG4105BZS acriflavin resistance protein E5Y90_RS10540 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E5Y90_RS10545 ENOG4105K8R UPF0145 protein E5Y90_RS10550 ENOG4105K8R UPF0145 protein E5Y90_RS10605 ENOG4108VWS Yaeq family E5Y90_RS10610 ENOG4105CKI cobalamin synthesis protein E5Y90_RS10625 ENOG4108W5M transcriptional regulator E5Y90_RS10630 ENOG4105CZM Major Facilitator E5Y90_RS10640 ENOG4108S4H thioesterase Superfamily protein E5Y90_RS10650 ENOG4105D78 K07001 NTE family protein E5Y90_RS10660 ENOG4105D6U Sodium Glutamate Symporter E5Y90_RS10670 ENOG4105C2C drug resistance transporter, Bcr CflA E5Y90_RS10675 ENOG4105EM2 membrane E5Y90_RS10685 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E5Y90_RS10745 ENOG4105WD1 Membrane E5Y90_RS10775 ENOG4105C8Q Methyl-accepting chemotaxis E5Y90_RS10780 ENOG4108ZGA chew protein E5Y90_RS10785 ENOG4105M3Z response regulator E5Y90_RS10790 ENOG4108UNF response regulator E5Y90_RS10800 ENOG4105D0S secretion protein (HlyD E5Y90_RS10845 ENOG4105H1G trap transporter solute receptor taxi family E5Y90_RS10860 ENOG4105D1F ATP-binding protein E5Y90_RS10870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) E5Y90_RS10890 ENOG4105K6H D-cysteine desulfhydrase E5Y90_RS10895 ENOG4105CBX hi0933 family E5Y90_RS10925 ENOG4105DP0 ferredoxin-NADP reductase E5Y90_RS10930 ENOG4105DUM transcriptional regulator, lysR family E5Y90_RS10950 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) E5Y90_RS10960 ENOG4105C8S subunit m E5Y90_RS10965 ENOG4105D65 subunit l E5Y90_RS10970 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E5Y90_RS10975 ENOG4107UFS subunit j E5Y90_RS10980 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E5Y90_RS10990 ENOG4108IEH NADH dehydrogenase subunit g E5Y90_RS10995 ENOG4107QIZ NADH dehydrogenase E5Y90_RS11000 ENOG4105GKE subunit e E5Y90_RS11015 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain E5Y90_RS11025 ENOG4105JJR Histidine kinase E5Y90_RS11030 ENOG4107EXC regulatoR E5Y90_RS11035 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5Y90_RS11040 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5Y90_RS11080 ENOG4107XGZ Hydrolase E5Y90_RS11085 ENOG4105DWF phosphomethylpyrimidine kinase E5Y90_RS11090 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E5Y90_RS11105 ENOG4105D3G Pseudouridine synthase E5Y90_RS11135 ENOG4105DTD Dehydrogenase E5Y90_RS11145 ENOG4105CY2 Citrate transporter E5Y90_RS11150 ENOG4108I0Z Aconitate hydratase E5Y90_RS11155 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) E5Y90_RS11165 ENOG4105RK9 auxin efflux carrier E5Y90_RS11170 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5Y90_RS11180 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E5Y90_RS11185 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) E5Y90_RS11190 ENOG4105CI3 gtp-binding protein typa E5Y90_RS11195 ENOG4105C2W permease E5Y90_RS11205 ENOG4108IQI permease E5Y90_RS11225 ENOG4105CHU acetyl-coa acetyltransferase E5Y90_RS11240 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E5Y90_RS11250 ENOG4108R6W Transcriptional regulator, ARAC family E5Y90_RS11255 ENOG4105CHU acetyl-coa acetyltransferase E5Y90_RS11260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E5Y90_RS11280 ENOG4108UT2 hemolysin iii E5Y90_RS11285 ENOG4105CSH Transporter E5Y90_RS11300 ENOG4107RZC phospholipase d E5Y90_RS11310 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E5Y90_RS11335 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) E5Y90_RS11340 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) E5Y90_RS11345 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E5Y90_RS11355 ENOG4108UJD 30S ribosomal protein S9 E5Y90_RS11360 ENOG4107MKT Stringent starvation protein a E5Y90_RS11365 ENOG4105KB2 stringent starvation protein b E5Y90_RS11405 ENOG4108KHX Diguanylate cyclase E5Y90_RS11410 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 E5Y90_RS11440 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) E5Y90_RS11445 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) E5Y90_RS11460 ENOG4105D3R alkyl hydroperoxide reductase E5Y90_RS11475 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E5Y90_RS11480 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) E5Y90_RS11515 ENOG4108VIA integral membrane protein E5Y90_RS11520 ENOG4105II7 pyrroline-5-carboxylate reductase E5Y90_RS11525 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E5Y90_RS11535 ENOG4105C9X ppx gppa phosphatase E5Y90_RS11545 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E5Y90_RS11560 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E5Y90_RS11565 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) E5Y90_RS11595 ENOG4105W39 Membrane E5Y90_RS11605 ENOG4105CYM Glutathione S-transferase E5Y90_RS11615 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E5Y90_RS11635 ENOG4105CEY Amp-dependent synthetase and ligase E5Y90_RS11650 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) E5Y90_RS11660 ENOG4108V0P LemA family E5Y90_RS11670 ENOG4105VIE preprotein translocase, subunit YajC E5Y90_RS11675 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E5Y90_RS11680 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E5Y90_RS11695 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5Y90_RS11710 ENOG4105C6T cysteine synthase E5Y90_RS11715 ENOG4105BZU Histidine kinase E5Y90_RS11725 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5Y90_RS11730 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E5Y90_RS11770 ENOG4105C1G acyl-Coa dehydrogenase E5Y90_RS11775 ENOG4105CT3 Monooxygenase E5Y90_RS11780 ENOG4108ZT0 50S ribosomal protein l17 E5Y90_RS11790 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) E5Y90_RS11810 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E5Y90_RS11825 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) E5Y90_RS11835 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) E5Y90_RS11840 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) E5Y90_RS11845 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) E5Y90_RS11875 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) E5Y90_RS11890 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) E5Y90_RS11900 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) E5Y90_RS11905 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) E5Y90_RS11910 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) E5Y90_RS11955 ENOG4105CK2 sodium dicarboxylate symporter E5Y90_RS11960 ENOG4105C29 acyl-CoA thioesterase E5Y90_RS11965 ENOG4105E55 glycerol-3-phosphate acyltransferase E5Y90_RS11975 ENOG4105CB5 ATP-dependent DNA helicase recG E5Y90_RS11980 ENOG4105MJ2 Competence protein E5Y90_RS11990 ENOG4108URH decarboxylase E5Y90_RS11995 ENOG4107QUT magnesium and cobalt transport protein CorA E5Y90_RS12005 ENOG4105E3I toluene tolerance E5Y90_RS12010 ENOG4107PE3 Mammalian cell entry related domain protein E5Y90_RS12015 ENOG4105CY3 ABC transporter, permease E5Y90_RS12020 ENOG4105DHJ ABC, transporter E5Y90_RS12025 ENOG4105C1J atp-dependent rna helicase E5Y90_RS12030 ENOG4105ECY inositol monophosphatase E5Y90_RS12035 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E5Y90_RS12050 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) E5Y90_RS12065 ENOG4105CSU acyl-Coa dehydrogenase E5Y90_RS12070 ENOG4105VEQ Cold shock protein E5Y90_RS12075 ENOG4105CSA Coproporphyrinogen iii oxidase E5Y90_RS12085 ENOG4107QI1 Mate efflux family protein E5Y90_RS12100 ENOG4105WMR Protein CrcB homolog E5Y90_RS12115 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) E5Y90_RS12130 ENOG4107SKI cobyrinic Acid a,c-diamide synthase E5Y90_RS12135 ENOG4105IPI Membrane E5Y90_RS12140 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5Y90_RS12145 ENOG4105VCH membrane E5Y90_RS12150 ENOG4107QF7 multi-drug E5Y90_RS12165 ENOG4105CQB FAD linked oxidase domain protein E5Y90_RS12170 ENOG4108JQ1 Dehydrogenase E5Y90_RS12180 ENOG4107AQZ Membrane E5Y90_RS12195 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) E5Y90_RS12200 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) E5Y90_RS12205 ENOG4107IFA Lipase (EC 3.1.1.3) E5Y90_RS12220 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) E5Y90_RS12225 ENOG4105K5M 30s ribosomal protein S16 E5Y90_RS12270 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E5Y90_RS12275 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) E5Y90_RS12280 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5Y90_RS12285 ENOG4105KME endoribonuclease L-psp E5Y90_RS12290 ENOG4105W53 bacterioferritin-associated ferredoxin E5Y90_RS12295 ENOG4108UQY Iron-storage protein E5Y90_RS12300 ENOG4108YSG O-Antigen polymerase E5Y90_RS12305 ENOG4108YSG O-Antigen polymerase E5Y90_RS12310 ENOG4105X0D Fimbrial protein E5Y90_RS12395 ENOG4108V0P LemA family E5Y90_RS12405 ENOG4105BZ8 glutamate synthase E5Y90_RS12410 ENOG4105CBC glutamate synthase E5Y90_RS12430 ENOG4105E4G Type IV pilus E5Y90_RS12455 ENOG4108JQC penicillin-binding protein 1A E5Y90_RS12460 ENOG4105DHI Methyltransferase E5Y90_RS12465 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) E5Y90_RS12470 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E5Y90_RS12475 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E5Y90_RS12480 ENOG4105CJN penicillin-binding protein E5Y90_RS12495 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E5Y90_RS12525 ENOG4105C5H ABC transporter E5Y90_RS12535 ENOG4105PDP Short chain dehydrogenase E5Y90_RS12540 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E5Y90_RS12555 ENOG4105D65 subunit l E5Y90_RS12560 ENOG4108ZE9 Monovalent cation H antiporter subunit C E5Y90_RS12565 ENOG4107R4Z monovalent cation h antiporter subunit d E5Y90_RS12570 ENOG4105SC1 monovalent cation H antiporter subunit E E5Y90_RS12575 ENOG4105W4C monovalent cation H antiporter subunit F E5Y90_RS12580 ENOG4105KJM monovalent cation h antiporter subunit g E5Y90_RS12585 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) E5Y90_RS12595 ENOG4105CHV Transcription elongation factor NusA E5Y90_RS12630 ENOG4107EJC Preprotein translocase subunit SecG E5Y90_RS12635 ENOG4105CP7 Triose-phosphate isomerase E5Y90_RS12640 ENOG4107QHF type ii secretion system protein e E5Y90_RS12655 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E5Y90_RS12665 ENOG4105C2N RNA methyltransferase TrmH family group 3 E5Y90_RS12670 ENOG4105NBK UPF0345 protein E5Y90_RS12675 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E5Y90_RS12685 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) E5Y90_RS12695 ENOG4105BZ1 (ABC) transporter E5Y90_RS12705 ENOG4107QJZ Glycosyl transferase, family 2 E5Y90_RS12710 ENOG4108UTW Plays a role in the regulation of phosphate uptake E5Y90_RS12715 ENOG4105DFG type I secretion outer membrane protein E5Y90_RS12730 ENOG41087AY ADP-Ribose pyrophosphatase E5Y90_RS12735 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E5Y90_RS12745 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E5Y90_RS12755 ENOG4105CNI cell division protein FtsW E5Y90_RS12770 ENOG4105CE1 Ferrous iron transport protein b E5Y90_RS12780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5Y90_RS12785 ENOG4105T95 Thiol disulfide interChange protein E5Y90_RS12790 ENOG4105D6E homoserine dehydrogenase E5Y90_RS12800 ENOG41061WM D-Alanyl-D-Alanine E5Y90_RS12810 ENOG4105BZU Histidine kinase E5Y90_RS12815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5Y90_RS12820 ENOG4105CN1 protease E5Y90_RS12825 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) E5Y90_RS12830 ENOG4108K5H permease YjgP YjgQ family protein E5Y90_RS12835 ENOG4108M8S permease YjgP YjgQ family protein E5Y90_RS12855 ENOG4105DQR SNARE associated Golgi E5Y90_RS12870 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E5Y90_RS12880 ENOG4105BZU Histidine kinase E5Y90_RS12895 ENOG4105C0P Mg chelatase subunit ChlI E5Y90_RS12905 ENOG4105J5J Outer membrane porin E5Y90_RS12910 ENOG4105F0N pyrophosphate phospho-hydrolase E5Y90_RS12925 ENOG4105CEY Amp-dependent synthetase and ligase E5Y90_RS12930 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5Y90_RS12935 ENOG41079KZ Major Facilitator Superfamily E5Y90_RS12940 ENOG4105EN6 Membrane E5Y90_RS12950 ENOG4105EE5 Membrane protein terC E5Y90_RS12955 ENOG4108URH decarboxylase E5Y90_RS12965 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5Y90_RS12975 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E5Y90_RS12990 ENOG4105CCT upf0313 protein E5Y90_RS12995 ENOG4105D94 Major Facilitator Superfamily E5Y90_RS13045 ENOG4105C79 DNA protecting protein DprA E5Y90_RS13055 ENOG4105SX7 Transporter E5Y90_RS13070 ENOG4108V06 Glutathione peroxidase E5Y90_RS13095 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) E5Y90_RS13145 ENOG4105FDK ABC transporter E5Y90_RS13150 ENOG4105FAV ABC, transporter E5Y90_RS13155 ENOG4105EWC Purine nucleoside phosphorylase E5Y90_RS13165 ENOG410829K Lysine exporter protein (Lyse ygga) E5Y90_RS13170 ENOG4105EZR dyp-type peroxidase family protein E5Y90_RS13180 ENOG4108QDE fad dependent oxidoreductase E5Y90_RS13185 ENOG4105EUB pirin domain protein E5Y90_RS13200 ENOG4105D3R alkyl hydroperoxide reductase E5Y90_RS13230 ENOG4108UUM single-stranded DNA-binding protein E5Y90_RS13235 ENOG4107RDB Major Facilitator E5Y90_RS13245 ENOG4105DWF phosphomethylpyrimidine kinase E5Y90_RS13255 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E5Y90_RS13270 ENOG4105C94 Transporter E5Y90_RS13280 ENOG4107QN1 sodium solute E5Y90_RS13285 ENOG41062QD Membrane E5Y90_RS13290 ENOG4105BZU Histidine kinase E5Y90_RS13305 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E5Y90_RS13315 ENOG4105D64 Mechanosensitive ion channel E5Y90_RS13325 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E5Y90_RS13330 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5Y90_RS13360 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E5Y90_RS13375 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E5Y90_RS13395 ENOG4107QSN dihydrolipoamide acetyltransferase E5Y90_RS13400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E5Y90_RS13405 ENOG41063SB peptidase E5Y90_RS13420 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E5Y90_RS13425 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E5Y90_RS13430 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E5Y90_RS13440 ENOG4105DFU Cell wall formation (By similarity) E5Y90_RS13450 ENOG4105D7Z glutathione synthase E5Y90_RS13465 ENOG4105E3B Multicopper oxidase E5Y90_RS13480 ENOG4108ZX5 transcriptional regulator E5Y90_RS13485 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr E5Y90_RS13490 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) E5Y90_RS13495 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5Y90_RS13505 ENOG4107QKV phosphomannomutase E5Y90_RS13510 ENOG4105CMR udp-glucose 4-epimerase E5Y90_RS13520 ENOG4105C6Y Udp-glucose 6-dehydrogenase E5Y90_RS13525 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E5Y90_RS13535 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E5Y90_RS13540 ENOG4107WZ3 Transferase E5Y90_RS13545 ENOG4105D3Q Sugar transferase E5Y90_RS13550 ENOG4105CGN Glycosyl transferase (Group 1 E5Y90_RS13565 ENOG4108KMV Glycosyl transferase (Group 1 E5Y90_RS13580 ENOG4107QQG Dehydrogenase E5Y90_RS13585 ENOG4105DAY polysaccharide export protein E5Y90_RS13595 ENOG4105D75 Capsular exopolysaccharide family E5Y90_RS13600 ENOG4108MRJ E5Y90_RS13605 ENOG4108V1T peptidylprolyl cis-trans isomerase E5Y90_RS13610 ENOG4108V1T peptidylprolyl cis-trans isomerase E5Y90_RS13625 ENOG4105CEN a g-specific adenine glycosylase E5Y90_RS13630 ENOG4105FAA peptidase M23 E5Y90_RS13655 ENOG4108R3E Dna-3-methyladenine glycosylase i E5Y90_RS13660 ENOG4105DQ4 alcohol dehydrogenase E5Y90_RS13670 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) E5Y90_RS13685 ENOG4105KHC sulfurtransferase E5Y90_RS13705 ENOG4105D7V transposase E5Y90_RS13715 ENOG4105EAC phosphoserine phosphatase E5Y90_RS13725 ENOG4105C09 Bile acid E5Y90_RS13730 ENOG4108RWI nicotinamidase E5Y90_RS13735 ENOG4108SC4 )-transporter E5Y90_RS13740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E5Y90_RS13750 ENOG4105C8V SAICAR synthetase E5Y90_RS13755 ENOG4105D1H recombination factor protein RarA E5Y90_RS13765 ENOG4108ZZ3 UPF0260 protein E5Y90_RS13775 ENOG4105CJR Integral membrane protein (MviN E5Y90_RS13780 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E5Y90_RS13785 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E5Y90_RS13790 ENOG4105HSS phospholipase C E5Y90_RS13795 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) E5Y90_RS13800 ENOG4105EJ2 Transcriptional regulator E5Y90_RS13805 ENOG4108Z33 Thiol disulfide Interchange Protein E5Y90_RS13810 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) E5Y90_RS13815 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E5Y90_RS13820 ENOG4105UBK short-chain dehydrogenase reductase E5Y90_RS13845 ENOG4107QZM n-acetylglutamate synthase E5Y90_RS13850 ENOG4108R86 Transcriptional regulator E5Y90_RS13860 ENOG4105DTN riboflavin biosynthesis protein ribF E5Y90_RS13865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E5Y90_RS13875 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E5Y90_RS13915 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) E5Y90_RS13920 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) E5Y90_RS13925 ENOG4105CVE Lytic murein transglycosylase E5Y90_RS13930 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E5Y90_RS13935 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E5Y90_RS13945 ENOG4105DFU Cell wall formation (By similarity) E5Y90_RS13955 ENOG4105F27 Major Facilitator E5Y90_RS13960 ENOG4105DU1 integral membrane protein, terc E5Y90_RS13965 ENOG4107QUY Guanine deaminase E5Y90_RS13970 ENOG4108UGV hypoxanthine phosphoribosyltransferase E5Y90_RS13980 ENOG4105T95 Thiol disulfide interChange protein E5Y90_RS13995 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E5Y90_RS14000 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) E5Y90_RS14005 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) E5Y90_RS14020 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) E5Y90_RS14035 ENOG4105E39 Enoyl-CoA hydratase E5Y90_RS14050 ENOG4105CEY Amp-dependent synthetase and ligase E5Y90_RS14375 ENOG4108UUM single-stranded DNA-binding protein E5Y90_RS14410 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5Y90_RS14605 ENOG4108IG5 Transcriptional regulator E5Y90_RS14805 ENOG4105M6W Crispr-associated protein, Csy3 family E5Y90_RS14815 ENOG4105ENG CRISPR-associated protein, Csy1 family E5Y90_RS15180 ENOG4105CZX twitching motility protein E5Y90_RS15255 ENOG4105DR5 peptidase E5Y90_RS15440 ENOG4108K0D peptidase, M48 E5Y90_RS15450 ENOG4105J7D transcriptional regulator E5Y90_RS15470 ENOG4105CHR reductase E5Y90_RS15630 ENOG4108JJ7 ABC transporter E5Y90_RS15680 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5Y90_RS15695 ENOG410814C multidrug resistance protein E5Y90_RS15705 ENOG4106032 Glutathionylspermidine synthase E5Y90_RS15780 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS E5Y90_RS15805 ENOG4105KK6 nuclease E5Y90_RS15935 ENOG4105F5W AtP-binding protein E5Y90_RS16000 ENOG4105CY2 Citrate transporter E5Y90_RS16005 ENOG4105C0A alcohol dehydrogenase E5Y90_RS16010 ENOG4105C26 Dehydrogenase E5Y90_RS16015 ENOG4108FUF Transcriptional regulator, IclR family E5Y90_RS16065 ENOG4105E4P ATPase (AAA E5Y90_RS16130 ENOG4105C26 Dehydrogenase E5Y90_RS16140 ENOG4105C26 Dehydrogenase E5Y90_RS16145 ENOG4105C0A alcohol dehydrogenase E5Y90_RS16185 ENOG4108FUF Transcriptional regulator, IclR family E5Y90_RS16195 ENOG4108BUD transposase E5Y90_RS16215 ENOG4105XUP Phage derived protein Gp49-like (DUF891) E5Y90_RS16255 ENOG4105EKQ RNA-directed DNA polymerase E5Y90_RS16340 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase E5Y90_RS16360 ENOG4108BUD transposase E5Y90_RS16370 ENOG4108C33 Resolvase E5Y90_RS16380 ENOG4108R0M Aminoglycoside E5Y90_RS16405 ENOG4105W1Y Transcriptional regulator E5Y90_RS16435 ENOG4108C66 Inherit from COG: DNA primase E5Y90_RS16455 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E5Y90_RS16500 ENOG4105MZU cell filamentation protein E5Y90_RS16515 ENOG4105E5H Transposase E5Y90_RS16635 ENOG4105IYK transposase E5Y90_RS16640 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) E5Y90_RS16645 ENOG4107QJE Chromosome Partitioning Protein E5Y90_RS16785 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) E5Y90_RS16790 ENOG4107QJE Chromosome Partitioning Protein E5Y90_RS16805 ENOG4108NE4 E5Y90_RS16825 ENOG4108HWY Beta-lactamase E5Y90_RS16835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5Y90_RS16840 ENOG4105BZU Histidine kinase E5Y90_RS16850 ENOG4105BZS acriflavin resistance protein E5Y90_RS16855 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5Y90_RS16965 ENOG4108W2Y isochorismatase E5Y90_RS16970 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein E5Y90_RS17000 ENOG4105CH6 catalase E5Y90_RS17055 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) E5Y90_RS17080 ENOG4107Z6W Protein CrcB homolog E5Y90_RS17090 ENOG4105CHH sulfate transporter E5Y90_RS17140 ENOG4105WJ3 XRE family Transcriptional regulator E5Y90_RS17245 ENOG410814C multidrug resistance protein E5Y90_RS17255 ENOG4105XUP Phage derived protein Gp49-like (DUF891)