locus-tag	class	description
E5Y90_RS00010	COG0592	DNA-directed DNA polymerase activity
E5Y90_RS00025	COG1063	alcohol dehydrogenase
E5Y90_RS00030	COG0488	(ABC) transporter
E5Y90_RS00050	COG0316	Belongs to the HesB IscA family
E5Y90_RS00090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5Y90_RS00125	COG2814	Major facilitator Superfamily
E5Y90_RS00130	COG2814	Major facilitator Superfamily
E5Y90_RS00140	COG0666	response to abiotic stimulus
E5Y90_RS00145	COG0693	protein deglycase activity
E5Y90_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
E5Y90_RS00160	COG0733	neurotransmitter:sodium symporter activity
E5Y90_RS00170	COG0428	transporter
E5Y90_RS00195	COG0129	dihydroxy-acid dehydratase activity
E5Y90_RS00220	COG2233	PERMEase
E5Y90_RS00235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_RS00285	COG2733	membrane
E5Y90_RS00300	COG2918	glutathione biosynthetic process
E5Y90_RS00305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5Y90_RS00315	COG3150	esterase
E5Y90_RS00360	COG3706	GGDEF domain
E5Y90_RS00365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5Y90_RS00380	COG1393	Belongs to the ArsC family
E5Y90_RS00385	COG0708	Exodeoxyribonuclease III
E5Y90_RS00395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5Y90_RS00405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5Y90_RS00410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E5Y90_RS00440	COG4771	TonB-dependent receptor
E5Y90_RS00480	COG4521	taurine ABC transporter
E5Y90_RS00485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5Y90_RS00490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5Y90_RS00495	COG2175	clavaminate synthase activity
E5Y90_RS00505	COG2186	Transcriptional regulator
E5Y90_RS00515	COG0277	FAD linked oxidase domain protein
E5Y90_RS00560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5Y90_RS00645	COG1074	ATP-dependent DNA helicase activity
E5Y90_RS00660	COG4372	Transposase
E5Y90_RS00670	COG2963	transposase activity
E5Y90_RS00700	COG3727	T/G mismatch-specific endonuclease activity
E5Y90_RS00705	COG0270	DNA (cytosine-5-)-methyltransferase activity
E5Y90_RS00745	COG3756	Protein conserved in bacteria
E5Y90_RS00790	COG1192	Involved in chromosome partitioning
E5Y90_RS00805	COG0586	Pfam SNARE associated Golgi protein
E5Y90_RS00810	COG3111	PFAM Bacterial OB fold (BOF) protein
E5Y90_RS00815	COG0519	Catalyzes the synthesis of GMP from XMP
E5Y90_RS00815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5Y90_RS00820	COG3706	GGDEF domain
E5Y90_RS00855	COG0534	Mate efflux family protein
E5Y90_RS00905	COG3158	transport of potassium into the cell
E5Y90_RS00940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5Y90_RS00975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5Y90_RS01030	COG0183	Belongs to the thiolase family
E5Y90_RS01065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5Y90_RS01080	COG3275	phosphorelay sensor kinase activity
E5Y90_RS01090	COG0181	hydroxymethylbilane synthase activity
E5Y90_RS01110	COG0824	Thioesterase
E5Y90_RS01140	COG0546	phosphoglycolate phosphatase activity
E5Y90_RS01190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5Y90_RS01195	COG0081	regulation of translation
E5Y90_RS01200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5Y90_RS01210	COG0085	RNA polymerase activity
E5Y90_RS01240	COG2056	Na+-H+ antiporter family
E5Y90_RS01255	COG0326	Molecular chaperone. Has ATPase activity
E5Y90_RS01285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5Y90_RS01290	COG0427	acetyl-CoA hydrolase
E5Y90_RS01295	COG2205	protein histidine kinase activity
E5Y90_RS01300	COG0745	RESPONSE REGULATOR receiver
E5Y90_RS01320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5Y90_RS01350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5Y90_RS01355	COG1074	ATP-dependent DNA helicase activity
E5Y90_RS01360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Y90_RS01370	COG1185	polyribonucleotide nucleotidyltransferase activity
E5Y90_RS01375	COG0598	Magnesium transport protein CorA
E5Y90_RS01380	COG2841	Protein conserved in bacteria
E5Y90_RS01385	COG0789	Transcriptional regulator
E5Y90_RS01395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5Y90_RS01405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5Y90_RS01430	COG4535	Mg2 and Co2 transporter CorC
E5Y90_RS01435	COG0425	Belongs to the sulfur carrier protein TusA family
E5Y90_RS01440	COG3501	Rhs element vgr protein
E5Y90_RS01455	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5Y90_RS01455	COG0644	oxidoreductase
E5Y90_RS01465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5Y90_RS01480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Y90_RS01485	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5Y90_RS01495	COG0493	'glutamate synthase
E5Y90_RS01505	COG2226	methyltransferase
E5Y90_RS01520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5Y90_RS01540	COG0751	glycine-tRNA ligase activity
E5Y90_RS01555	COG0471	metal ion transport
E5Y90_RS01565	COG1983	PspC domain protein
E5Y90_RS01590	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_RS01595	COG1530	ribonuclease E activity
E5Y90_RS01605	COG0546	phosphoglycolate phosphatase activity
E5Y90_RS01610	COG3971	2-oxopent-4-enoate hydratase activity
E5Y90_RS01615	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E5Y90_RS01635	COG2963	transposase activity
E5Y90_RS01645	COG4372	Transposase
E5Y90_RS01650	COG0583	DNA-binding transcription factor activity
E5Y90_RS01655	COG4638	Rieske (2fe-2S)
E5Y90_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS01675	COG3384	dioxygenase
E5Y90_RS01680	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_RS01700	COG3011	Protein conserved in bacteria
E5Y90_RS01705	COG0753	catalase activity
E5Y90_RS01710	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS01755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5Y90_RS01770	COG0473	3-isopropylmalate dehydrogenase activity
E5Y90_RS01820	COG1560	Kdo2-lipid A biosynthetic process
E5Y90_RS01830	COG2900	Belongs to the SlyX family
E5Y90_RS01865	COG1929	Belongs to the glycerate kinase type-1 family
E5Y90_RS01875	COG0724	RNA recognition motif
E5Y90_RS01890	COG4651	solute:proton antiporter activity
E5Y90_RS01890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5Y90_RS01915	COG0788	formyltetrahydrofolate deformylase activity
E5Y90_RS01955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5Y90_RS01995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5Y90_RS02010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5Y90_RS02015	COG0583	DNA-binding transcription factor activity
E5Y90_RS02025	COG2813	Specifically methylates the guanine in position
E5Y90_RS02025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5Y90_RS02030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5Y90_RS02035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5Y90_RS02045	COG4774	siderophore transport
E5Y90_RS02050	COG4771	TonB-dependent receptor
E5Y90_RS02060	COG0740	serine-type endopeptidase activity
E5Y90_RS02075	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5Y90_RS02075	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5Y90_RS02085	COG1414	Transcriptional regulator
E5Y90_RS02095	COG1454	alcohol dehydrogenase
E5Y90_RS02100	COG2610	gluconate transmembrane transporter activity
E5Y90_RS02105	COG0280	phosphate acetyltransferase
E5Y90_RS02105	COG0857	belongs to the CobB CobQ family
E5Y90_RS02110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5Y90_RS02135	COG0793	Belongs to the peptidase S41A family
E5Y90_RS02150	COG2814	Major facilitator Superfamily
E5Y90_RS02170	COG0697	spore germination
E5Y90_RS02180	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5Y90_RS02185	COG0339	signal peptide processing
E5Y90_RS02195	COG0557	exoribonuclease II activity
E5Y90_RS02230	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5Y90_RS02235	COG1295	ribonuclease BN
E5Y90_RS02280	COG1702	phosphate starvation-inducible protein PhoH
E5Y90_RS02290	COG0739	heme binding
E5Y90_RS02290	COG0741	lytic transglycosylase activity
E5Y90_RS02290	COG1196	nuclear chromosome segregation
E5Y90_RS02330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5Y90_RS02335	COG1183	phosphatidylcholine synthase activity
E5Y90_RS02400	COG1607	acyl-coa hydrolase
E5Y90_RS02430	COG2350	Protein conserved in bacteria
E5Y90_RS02445	COG3781	membrane
E5Y90_RS02450	COG2003	Belongs to the UPF0758 family
E5Y90_RS02455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5Y90_RS02465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5Y90_RS02470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5Y90_RS02480	COG0726	polysaccharide deacetylase
E5Y90_RS02485	COG0084	hydrolase, TatD family'
E5Y90_RS02500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5Y90_RS02510	COG1162	GTPase activity
E5Y90_RS02515	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5Y90_RS02520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5Y90_RS02530	COG1538	Outer membrane efflux protein
E5Y90_RS02535	COG0577	efflux transmembrane transporter activity
E5Y90_RS02535	COG1136	(ABC) transporter
E5Y90_RS02540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_RS02550	COG2963	transposase activity
E5Y90_RS02560	COG4372	Transposase
E5Y90_RS02590	COG0028	Belongs to the TPP enzyme family
E5Y90_RS02595	COG0440	acetolactate synthase activity
E5Y90_RS02635	COG2975	iron-sulfur cluster assembly
E5Y90_RS02650	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E5Y90_RS02655	COG1426	Protein conserved in bacteria
E5Y90_RS02665	COG0124	histidyl-tRNA synthetase
E5Y90_RS02695	COG0300	oxidoreductase activity
E5Y90_RS02700	COG3956	TIGRFAM MazG family protein
E5Y90_RS02705	COG1555	photosystem II stabilization
E5Y90_RS02705	COG1596	polysaccharide export
E5Y90_RS02710	COG0617	tRNA 3'-terminal CCA addition
E5Y90_RS02715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5Y90_RS02730	COG1660	Displays ATPase and GTPase activities
E5Y90_RS02735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5Y90_RS02740	COG3028	Belongs to the UPF0307 family
E5Y90_RS02745	COG2205	protein histidine kinase activity
E5Y90_RS02750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5Y90_RS02795	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5Y90_RS02815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5Y90_RS02820	COG0463	Glycosyl transferase, family 2
E5Y90_RS02845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5Y90_RS02880	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS02885	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS02895	COG2205	protein histidine kinase activity
E5Y90_RS02900	COG0745	RESPONSE REGULATOR receiver
E5Y90_RS02910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5Y90_RS02925	COG2096	Adenosyltransferase
E5Y90_RS02930	COG4206	TonB-dependent receptor
E5Y90_RS02970	COG1764	response to oxidative stress
E5Y90_RS02975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Y90_RS03040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5Y90_RS03050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5Y90_RS03100	COG0494	nUDIX hydrolase
E5Y90_RS03110	COG1214	PFAM Peptidase M22, glycoprotease
E5Y90_RS03115	COG1968	undecaprenyl-diphosphatase activity
E5Y90_RS03130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5Y90_RS03145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5Y90_RS03180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5Y90_RS03205	COG0730	response to heat
E5Y90_RS03215	COG1196	nuclear chromosome segregation
E5Y90_RS03225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5Y90_RS03235	COG2193	ferroxidase activity
E5Y90_RS03280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5Y90_RS03285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5Y90_RS03295	COG0009	L-threonylcarbamoyladenylate synthase
E5Y90_RS03300	COG3101	peptidyl-lysine hydroxylation
E5Y90_RS03305	COG1399	metal-binding, possibly nucleic acid-binding protein
E5Y90_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS03325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5Y90_RS03330	COG1652	LysM domain
E5Y90_RS03350	COG0251	oxidation-reduction process
E5Y90_RS03355	COG1113	amino acid transport
E5Y90_RS03375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5Y90_RS03400	COG0456	acetyltransferase
E5Y90_RS03415	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5Y90_RS03420	COG0492	ferredoxin-NADP+ reductase activity
E5Y90_RS03425	COG0531	amino acid
E5Y90_RS03425	COG1674	ftsk spoiiie
E5Y90_RS03435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E5Y90_RS03445	COG0850	regulation of cytokinetic process
E5Y90_RS03455	COG0204	Acyl-transferase
E5Y90_RS03460	COG2885	chlorophyll binding
E5Y90_RS03465	COG0210	DNA helicase
E5Y90_RS03470	COG0756	dUTP diphosphatase activity
E5Y90_RS03490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Y90_RS03495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5Y90_RS03500	COG0121	glutamine amidotransferase
E5Y90_RS03525	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5Y90_RS03530	COG0735	belongs to the Fur family
E5Y90_RS03560	COG0420	3'-5' exonuclease activity
E5Y90_RS03570	COG1090	epimerase
E5Y90_RS03575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5Y90_RS03585	COG2050	protein possibly involved in aromatic compounds catabolism
E5Y90_RS03590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5Y90_RS03620	COG1785	Belongs to the alkaline phosphatase family
E5Y90_RS03625	COG1785	Belongs to the alkaline phosphatase family
E5Y90_RS03715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5Y90_RS03720	COG0477	Major facilitator Superfamily
E5Y90_RS03730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5Y90_RS03735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5Y90_RS03740	COG0730	response to heat
E5Y90_RS03745	COG0583	DNA-binding transcription factor activity
E5Y90_RS03760	COG2207	Transcriptional regulator
E5Y90_RS03780	COG0543	2 iron, 2 sulfur cluster binding
E5Y90_RS03780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5Y90_RS03785	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5Y90_RS03790	COG4638	Rieske (2fe-2S)
E5Y90_RS03820	COG4773	Receptor
E5Y90_RS03835	COG0583	DNA-binding transcription factor activity
E5Y90_RS03845	COG0657	acetylesterase activity
E5Y90_RS03870	COG0281	malic enzyme
E5Y90_RS03910	COG2871	sodium ion transport
E5Y90_RS03925	COG0640	Transcriptional regulator
E5Y90_RS03945	COG0783	Belongs to the Dps family
E5Y90_RS03965	COG0500	methyltransferase
E5Y90_RS03975	COG2223	nitrite transmembrane transporter activity
E5Y90_RS03980	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5Y90_RS03995	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E5Y90_RS04040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5Y90_RS04050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5Y90_RS04055	COG1077	Cell shape determining protein MreB Mrl
E5Y90_RS04060	COG1792	Involved in formation and maintenance of cell shape
E5Y90_RS04065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5Y90_RS04070	COG0424	maF-like protein
E5Y90_RS04075	COG1530	ribonuclease E activity
E5Y90_RS04085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5Y90_RS04095	COG0560	Phosphoserine phosphatase
E5Y90_RS04115	COG1113	amino acid transport
E5Y90_RS04120	COG0583	DNA-binding transcription factor activity
E5Y90_RS04125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5Y90_RS04130	COG4208	sulfate ABC transporter
E5Y90_RS04145	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5Y90_RS04155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5Y90_RS04175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Y90_RS04200	COG0571	ribonuclease III activity
E5Y90_RS04205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5Y90_RS04215	COG1381	Involved in DNA repair and RecF pathway recombination
E5Y90_RS04220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5Y90_RS04250	COG0436	Aminotransferase
E5Y90_RS04260	COG0052	Belongs to the universal ribosomal protein uS2 family
E5Y90_RS04280	COG2951	lytic endotransglycosylase activity
E5Y90_RS04295	COG0842	Transport permease protein
E5Y90_RS04300	COG1131	(ABC) transporter
E5Y90_RS04315	COG0584	glycerophosphoryl diester phosphodiesterase
E5Y90_RS04320	COG3118	belongs to the thioredoxin family
E5Y90_RS04375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5Y90_RS04380	COG1053	succinate dehydrogenase
E5Y90_RS04385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5Y90_RS04400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Y90_RS04425	COG1649	PFAM Uncharacterised BCR, COG1649
E5Y90_RS04425	COG0726	polysaccharide deacetylase
E5Y90_RS04455	COG0642	Histidine kinase
E5Y90_RS04460	COG0745	RESPONSE REGULATOR receiver
E5Y90_RS04500	COG0583	DNA-binding transcription factor activity
E5Y90_RS04565	COG3634	alkyl hydroperoxide reductase activity
E5Y90_RS04570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5Y90_RS04580	COG0789	Transcriptional regulator
E5Y90_RS04595	COG1720	tRNA m6t6A37 methyltransferase activity
E5Y90_RS04605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5Y90_RS04615	COG0745	RESPONSE REGULATOR receiver
E5Y90_RS04620	COG0642	Histidine kinase
E5Y90_RS04630	COG0494	nUDIX hydrolase
E5Y90_RS04640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5Y90_RS04645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5Y90_RS04650	COG3139	Protein of unknown function (DUF1315)
E5Y90_RS04660	COG1301	dicarboxylic acid transport
E5Y90_RS04665	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS04670	COG0693	protein deglycase activity
E5Y90_RS04675	COG1605	Chorismate mutase
E5Y90_RS04675	COG0077	Prephenate dehydratase
E5Y90_RS04680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5Y90_RS04685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5Y90_RS04710	COG2252	PERMEase
E5Y90_RS04715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5Y90_RS04730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5Y90_RS04740	COG0527	aspartate kinase activity
E5Y90_RS04750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5Y90_RS04765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5Y90_RS04780	COG1047	Peptidyl-prolyl cis-trans
E5Y90_RS04785	COG1686	Belongs to the peptidase S11 family
E5Y90_RS04800	COG3338	carbonate dehydratase activity
E5Y90_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS04825	COG2963	transposase activity
E5Y90_RS04835	COG4372	Transposase
E5Y90_RS04850	COG0584	glycerophosphoryl diester phosphodiesterase
E5Y90_RS04880	COG0436	Aminotransferase
E5Y90_RS04885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5Y90_RS04890	COG0386	Belongs to the glutathione peroxidase family
E5Y90_RS04895	COG0436	Aminotransferase
E5Y90_RS04900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5Y90_RS04915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5Y90_RS04935	COG3739	integral membrane protein
E5Y90_RS04950	COG3706	GGDEF domain
E5Y90_RS04980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5Y90_RS04985	COG0512	Glutamine amidotransferase of anthranilate synthase
E5Y90_RS04990	COG0174	glutamine synthetase
E5Y90_RS05000	COG3161	chorismate lyase activity
E5Y90_RS05005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5Y90_RS05050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5Y90_RS05055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5Y90_RS05060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5Y90_RS05090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5Y90_RS05095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Y90_RS05125	COG0556	nucleotide-excision repair
E5Y90_RS05170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5Y90_RS05170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5Y90_RS05200	COG3634	alkyl hydroperoxide reductase activity
E5Y90_RS05215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5Y90_RS05225	COG3178	'Phosphotransferase
E5Y90_RS05230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5Y90_RS05240	COG1192	Involved in chromosome partitioning
E5Y90_RS05245	COG1475	DNA binding
E5Y90_RS05250	COG0811	peptide transport
E5Y90_RS05260	COG1132	(ABC) transporter
E5Y90_RS05265	COG1663	tetraacyldisaccharide 4'-kinase activity
E5Y90_RS05285	COG0084	hydrolase, TatD family'
E5Y90_RS05290	COG1309	transcriptional regulator
E5Y90_RS05305	COG4795	General secretion pathway protein
E5Y90_RS05320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5Y90_RS05330	COG0590	tRNA wobble adenosine to inosine editing
E5Y90_RS05350	COG0776	regulation of translation
E5Y90_RS05365	COG2431	L-lysine efflux transmembrane transporter activity
E5Y90_RS05380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5Y90_RS05385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5Y90_RS05405	COG1253	flavin adenine dinucleotide binding
E5Y90_RS05420	COG0308	aminopeptidase N
E5Y90_RS05430	COG0589	response to stress
E5Y90_RS05445	COG3135	benzoate transporter
E5Y90_RS05455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5Y90_RS05460	COG0583	DNA-binding transcription factor activity
E5Y90_RS05475	COG0183	Belongs to the thiolase family
E5Y90_RS05495	COG2963	transposase activity
E5Y90_RS05505	COG4372	Transposase
E5Y90_RS05510	COG0431	NADPH-dependent FMN reductase
E5Y90_RS05515	COG0798	PFAM Bile acid sodium symporter
E5Y90_RS05520	COG0640	Transcriptional regulator
E5Y90_RS05525	COG1393	Belongs to the ArsC family
E5Y90_RS05560	COG1309	transcriptional regulator
E5Y90_RS05625	COG1114	Component of the transport system for branched-chain amino acids
E5Y90_RS05635	COG0583	DNA-binding transcription factor activity
E5Y90_RS05640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5Y90_RS05655	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_RS05655	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_RS05685	COG0148	phosphopyruvate hydratase activity
E5Y90_RS05700	COG0772	Belongs to the SEDS family
E5Y90_RS05710	COG4890	Cyd operon protein YbgT
E5Y90_RS05715	COG1294	oxidase, subunit
E5Y90_RS05735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_RS05745	COG0583	DNA-binding transcription factor activity
E5Y90_RS05795	COG2011	ABC-type metal ion transport system permease component
E5Y90_RS05800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5Y90_RS05805	COG1464	Belongs to the NlpA lipoprotein family
E5Y90_RS05815	COG0138	bifunctional purine biosynthesis protein purh
E5Y90_RS05820	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5Y90_RS05855	COG2814	Major facilitator Superfamily
E5Y90_RS05870	COG3852	Histidine kinase
E5Y90_RS05890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5Y90_RS05895	COG0575	Belongs to the CDS family
E5Y90_RS05910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5Y90_RS05920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_RS05925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5Y90_RS05930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_RS05945	COG2137	regulation of response to DNA damage stimulus
E5Y90_RS05950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5Y90_RS05955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5Y90_RS05960	COG1011	Hydrolase
E5Y90_RS05980	COG0268	Binds directly to 16S ribosomal RNA
E5Y90_RS05985	COG0702	epimerase
E5Y90_RS05990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5Y90_RS06000	COG2850	peptidyl-arginine hydroxylation
E5Y90_RS06010	COG0424	maF-like protein
E5Y90_RS06020	COG0126	phosphoglycerate kinase activity
E5Y90_RS06035	COG0697	spore germination
E5Y90_RS06045	COG0778	Nitroreductase
E5Y90_RS06055	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_RS06065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Y90_RS06070	COG3781	membrane
E5Y90_RS06085	COG5265	(ABC) transporter
E5Y90_RS06095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5Y90_RS06100	COG0824	Thioesterase
E5Y90_RS06105	COG1454	alcohol dehydrogenase
E5Y90_RS06110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5Y90_RS06130	COG0069	glutamate synthase activity
E5Y90_RS06155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5Y90_RS06175	COG0360	Binds together with S18 to 16S ribosomal RNA
E5Y90_RS06185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5Y90_RS06190	COG1845	cytochrome c oxidase, subunit III
E5Y90_RS06195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5Y90_RS06200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5Y90_RS06225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5Y90_RS06240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5Y90_RS06245	COG2890	protein-(glutamine-N5) methyltransferase activity
E5Y90_RS06265	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS06270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Y90_RS06285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5Y90_RS06310	COG0477	Major facilitator Superfamily
E5Y90_RS06315	COG0729	surface antigen
E5Y90_RS06500	COG5410	chromosome segregation
E5Y90_RS06645	COG3179	chitinase
E5Y90_RS06685	COG2391	methyltransferase activity
E5Y90_RS06700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5Y90_RS06710	COG2826	transposase and inactivated derivatives, IS30 family
E5Y90_RS06715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5Y90_RS06725	COG2353	YceI-like domain
E5Y90_RS06735	COG0519	Catalyzes the synthesis of GMP from XMP
E5Y90_RS06735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5Y90_RS06740	COG0625	glutathione transferase activity
E5Y90_RS06760	COG0517	IMP dehydrogenase activity
E5Y90_RS06760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5Y90_RS06765	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5Y90_RS06775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5Y90_RS06780	COG1137	ATPase activity
E5Y90_RS06785	COG1538	Outer membrane efflux protein
E5Y90_RS06810	COG0589	response to stress
E5Y90_RS06815	COG4122	O-methyltransferase activity
E5Y90_RS06825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5Y90_RS06845	COG2084	Dehydrogenase
E5Y90_RS06865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5Y90_RS06885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5Y90_RS06895	COG0133	tryptophan synthase activity
E5Y90_RS06900	COG0517	IMP dehydrogenase activity
E5Y90_RS06930	COG0612	Peptidase, M16
E5Y90_RS06935	COG0552	protein localization to endoplasmic reticulum
E5Y90_RS06950	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E5Y90_RS06995	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS07060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5Y90_RS07065	COG0730	response to heat
E5Y90_RS07070	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5Y90_RS07075	COG2207	Transcriptional regulator
E5Y90_RS07080	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5Y90_RS07085	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS07090	COG2169	Transcriptional regulator
E5Y90_RS07105	COG1271	oxidase subunit
E5Y90_RS07110	COG1294	oxidase, subunit
E5Y90_RS07120	COG1525	nuclease
E5Y90_RS07125	COG0583	DNA-binding transcription factor activity
E5Y90_RS07165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Y90_RS07170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5Y90_RS07180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5Y90_RS07185	COG2814	Major facilitator Superfamily
E5Y90_RS07200	COG1132	(ABC) transporter
E5Y90_RS07205	COG0668	transmembrane transport
E5Y90_RS07210	COG3122	Protein conserved in bacteria
E5Y90_RS07230	COG0640	Transcriptional regulator
E5Y90_RS07235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5Y90_RS07240	COG2217	Heavy metal translocating P-type atpase
E5Y90_RS07245	COG0789	Transcriptional regulator
E5Y90_RS07260	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS07265	COG0183	Belongs to the thiolase family
E5Y90_RS07270	COG0427	acetyl-CoA hydrolase
E5Y90_RS07285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5Y90_RS07290	COG0183	Belongs to the thiolase family
E5Y90_RS07295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_RS07300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5Y90_RS07305	COG3135	benzoate transporter
E5Y90_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS07315	COG0633	Ferredoxin
E5Y90_RS07315	COG0543	2 iron, 2 sulfur cluster binding
E5Y90_RS07320	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5Y90_RS07325	COG4638	Rieske (2fe-2S)
E5Y90_RS07335	COG4829	muconolactone delta-isomerase
E5Y90_RS07340	COG4948	Mandelate Racemase Muconate Lactonizing
E5Y90_RS07345	COG0583	DNA-binding transcription factor activity
E5Y90_RS07350	COG2814	Major facilitator Superfamily
E5Y90_RS07360	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_RS07365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5Y90_RS07365	COG1017	nitric oxide dioxygenase activity
E5Y90_RS07375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5Y90_RS07380	COG0583	DNA-binding transcription factor activity
E5Y90_RS07385	COG1944	ATP diphosphatase activity
E5Y90_RS07390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5Y90_RS07390	COG0644	oxidoreductase
E5Y90_RS07410	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS07430	COG4106	trans-aconitate 2-methyltransferase activity
E5Y90_RS07450	COG1454	alcohol dehydrogenase
E5Y90_RS07465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5Y90_RS07475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5Y90_RS07480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5Y90_RS07485	COG0022	dehydrogenase e1 component
E5Y90_RS07490	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5Y90_RS07495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5Y90_RS07500	COG2801	Transposase and inactivated derivatives
E5Y90_RS07505	COG2801	Transposase and inactivated derivatives
E5Y90_RS07535	COG0596	Alpha beta hydrolase
E5Y90_RS07595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5Y90_RS07605	COG0511	ligase activity, forming carbon-carbon bonds
E5Y90_RS07610	COG0439	Biotin carboxylase
E5Y90_RS07625	COG2814	Major facilitator Superfamily
E5Y90_RS07675	COG2199	diguanylate cyclase activity
E5Y90_RS07675	COG2203	Gaf domain
E5Y90_RS07680	COG2801	Transposase and inactivated derivatives
E5Y90_RS07695	COG0167	dihydroorotate dehydrogenase activity
E5Y90_RS07725	COG0372	Belongs to the citrate synthase family
E5Y90_RS07755	COG0542	response to heat
E5Y90_RS07760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5Y90_RS07770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5Y90_RS07785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5Y90_RS07790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5Y90_RS07795	COG0569	domain protein
E5Y90_RS07800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5Y90_RS07820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5Y90_RS07830	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5Y90_RS07850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5Y90_RS07880	COG0822	iron-sulfur transferase activity
E5Y90_RS07885	COG0316	Belongs to the HesB IscA family
E5Y90_RS07915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5Y90_RS07925	COG1027	Aspartate ammonia-lyase
E5Y90_RS07960	COG0352	thiamine-phosphate diphosphorylase activity
E5Y90_RS07975	COG3025	triphosphatase activity
E5Y90_RS08000	COG0612	Peptidase, M16
E5Y90_RS08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5Y90_RS08080	COG0154	amidase activity
E5Y90_RS08085	COG0477	Major facilitator Superfamily
E5Y90_RS08090	COG1522	sequence-specific DNA binding
E5Y90_RS08105	COG1610	YqeY-like protein
E5Y90_RS08115	COG4783	chaperone-mediated protein folding
E5Y90_RS08170	COG0778	Nitroreductase
E5Y90_RS08180	COG0513	Belongs to the DEAD box helicase family
E5Y90_RS08185	COG1278	Cold shock
E5Y90_RS08200	COG2363	Small membrane protein
E5Y90_RS08230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5Y90_RS08250	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_RS08255	COG1309	transcriptional regulator
E5Y90_RS08260	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS08265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5Y90_RS08270	COG1024	Enoyl-CoA hydratase
E5Y90_RS08275	COG4770	biotin carboxylase activity
E5Y90_RS08290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_RS08295	COG2031	fatty acid transporter
E5Y90_RS08310	COG0540	Belongs to the ATCase OTCase family
E5Y90_RS08325	COG0667	Aldo Keto reductase
E5Y90_RS08335	COG1765	OsmC-like protein
E5Y90_RS08340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5Y90_RS08365	COG0714	Associated with various cellular activities
E5Y90_RS08375	COG1966	Carbon starvation protein
E5Y90_RS08380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5Y90_RS08385	COG1509	lysine 2,3-aminomutase activity
E5Y90_RS08420	COG1067	ATP-dependent peptidase activity
E5Y90_RS08425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5Y90_RS08430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5Y90_RS08440	COG0583	DNA-binding transcription factor activity
E5Y90_RS08450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5Y90_RS08465	COG1686	Belongs to the peptidase S11 family
E5Y90_RS08470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5Y90_RS08480	COG1923	regulation of RNA biosynthetic process
E5Y90_RS08490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5Y90_RS08495	COG0802	atpase or kinase
E5Y90_RS08520	COG2707	UPF0756 membrane protein
E5Y90_RS08525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5Y90_RS08530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Y90_RS08545	COG1643	Atp-dependent helicase
E5Y90_RS08575	COG0482	sulfurtransferase activity
E5Y90_RS08580	COG2915	High frequency lysogenization protein hflD homolog
E5Y90_RS08600	COG0616	signal peptide processing
E5Y90_RS08610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5Y90_RS08620	COG0573	inorganic phosphate transmembrane transporter activity
E5Y90_RS08625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5Y90_RS08630	COG0076	glutamate decarboxylase activity
E5Y90_RS08635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5Y90_RS08665	COG2801	Transposase and inactivated derivatives
E5Y90_RS08705	COG0582	viral genome integration into host DNA
E5Y90_RS08710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5Y90_RS08720	COG1733	regulation of RNA biosynthetic process
E5Y90_RS08740	COG4372	Transposase
E5Y90_RS08750	COG2963	transposase activity
E5Y90_RS08760	COG1024	Enoyl-CoA hydratase
E5Y90_RS08765	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS08770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Y90_RS08785	COG0583	DNA-binding transcription factor activity
E5Y90_RS08790	COG0582	viral genome integration into host DNA
E5Y90_RS08805	COG3485	protocatechuate 3,4-dioxygenase
E5Y90_RS08810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5Y90_RS08815	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5Y90_RS08820	COG0583	DNA-binding transcription factor activity
E5Y90_RS08825	COG4948	Mandelate Racemase Muconate Lactonizing
E5Y90_RS08830	COG4829	muconolactone delta-isomerase
E5Y90_RS08835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5Y90_RS08840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5Y90_RS08905	COG4638	Rieske (2fe-2S)
E5Y90_RS08910	COG0154	amidase activity
E5Y90_RS08935	COG4372	Transposase
E5Y90_RS08945	COG2963	transposase activity
E5Y90_RS09000	COG0012	GTP binding
E5Y90_RS09005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5Y90_RS09010	COG1741	Belongs to the pirin family
E5Y90_RS09040	COG1518	maintenance of DNA repeat elements
E5Y90_RS09050	COG2072	flavoprotein involved in K transport
E5Y90_RS09065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5Y90_RS09085	COG3842	ATPase activity
E5Y90_RS09090	COG1840	ABC-type Fe3 transport system, periplasmic component
E5Y90_RS09105	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_RS09105	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_RS09120	COG5001	Diguanylate cyclase
E5Y90_RS09120	COG4251	negative regulation of phosphorylation
E5Y90_RS09120	COG3706	GGDEF domain
E5Y90_RS09120	COG2203	Gaf domain
E5Y90_RS09125	COG0418	dihydroorotase activity
E5Y90_RS09130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5Y90_RS09145	COG0833	amino acid
E5Y90_RS09155	COG0833	amino acid
E5Y90_RS09190	COG4239	(ABC) transporter, permease
E5Y90_RS09195	COG4174	ABC transporter (Permease)
E5Y90_RS09200	COG4166	transmembrane transport
E5Y90_RS09205	COG1388	LysM domain
E5Y90_RS09205	COG0741	lytic transglycosylase activity
E5Y90_RS09220	COG2816	NAD+ diphosphatase activity
E5Y90_RS09240	COG3107	peptidoglycan biosynthetic process
E5Y90_RS09255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5Y90_RS09260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5Y90_RS09265	COG2155	Conserved Protein
E5Y90_RS09270	COG0006	proline dipeptidase activity
E5Y90_RS09295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5Y90_RS09305	COG2234	aminopeptidase activity
E5Y90_RS09310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5Y90_RS09315	COG3384	dioxygenase
E5Y90_RS09330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5Y90_RS09335	COG2878	Part of a membrane complex involved in electron transport
E5Y90_RS09340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5Y90_RS09365	COG0768	penicillin binding
E5Y90_RS09370	COG0742	ribosomal rna small subunit methyltransferase
E5Y90_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS09390	COG0204	Acyl-transferase
E5Y90_RS09420	COG1597	lipid kinase activity
E5Y90_RS09445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5Y90_RS09445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5Y90_RS09460	COG0589	response to stress
E5Y90_RS09480	COG2321	neutral zinc metallopeptidase
E5Y90_RS09485	COG2354	Protein conserved in bacteria
E5Y90_RS09505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5Y90_RS09510	COG1773	rubredoxin
E5Y90_RS09515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5Y90_RS09525	COG0583	DNA-binding transcription factor activity
E5Y90_RS09545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5Y90_RS09550	COG4181	ATPase activity
E5Y90_RS09590	COG0306	phosphate transporter
E5Y90_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS09610	COG0525	valine-tRNA ligase activity
E5Y90_RS09645	COG2323	membrane
E5Y90_RS09665	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5Y90_RS09680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Y90_RS09685	COG0142	geranyltranstransferase activity
E5Y90_RS09690	COG2828	Protein conserved in bacteria
E5Y90_RS09700	COG2171	N-acyltransferase activity
E5Y90_RS09705	COG0602	queuosine metabolic process
E5Y90_RS09710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5Y90_RS09720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5Y90_RS09735	COG2353	YceI-like domain
E5Y90_RS09740	COG1056	cytidyltransferase-related domain
E5Y90_RS09740	COG1051	belongs to the nudix hydrolase family
E5Y90_RS09750	COG0778	Nitroreductase
E5Y90_RS09760	COG0047	phosphoribosylformylglycinamidine synthase activity
E5Y90_RS09760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5Y90_RS09780	COG2255	four-way junction helicase activity
E5Y90_RS09785	COG0824	Thioesterase
E5Y90_RS09805	COG0823	Involved in the tonB-independent uptake of proteins
E5Y90_RS09825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Y90_RS09855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5Y90_RS09860	COG0628	permease
E5Y90_RS09870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5Y90_RS09885	COG1560	Kdo2-lipid A biosynthetic process
E5Y90_RS09890	COG0658	competence protein
E5Y90_RS09890	COG2333	competence protein COMEC
E5Y90_RS09895	COG1136	(ABC) transporter
E5Y90_RS09915	COG1671	Belongs to the UPF0178 family
E5Y90_RS09955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_RS10005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5Y90_RS10010	COG0596	Alpha beta hydrolase
E5Y90_RS10030	COG1113	amino acid transport
E5Y90_RS10035	COG1115	amino acid carrier protein
E5Y90_RS10050	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E5Y90_RS10055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5Y90_RS10060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5Y90_RS10065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5Y90_RS10070	COG5001	Diguanylate cyclase
E5Y90_RS10070	COG1716	ATPase activity
E5Y90_RS10085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E5Y90_RS10095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5Y90_RS10100	COG2814	Major facilitator Superfamily
E5Y90_RS10105	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS10110	COG0583	DNA-binding transcription factor activity
E5Y90_RS10125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5Y90_RS10140	COG0037	tRNA processing
E5Y90_RS10145	COG0739	heme binding
E5Y90_RS10145	COG0741	lytic transglycosylase activity
E5Y90_RS10145	COG1196	nuclear chromosome segregation
E5Y90_RS10150	COG0501	Belongs to the peptidase M48B family
E5Y90_RS10160	COG2239	Acts as a magnesium transporter
E5Y90_RS10180	COG1253	flavin adenine dinucleotide binding
E5Y90_RS10215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5Y90_RS10225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5Y90_RS10230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5Y90_RS10250	COG0505	Belongs to the CarA family
E5Y90_RS10255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5Y90_RS10265	COG0415	Belongs to the DNA photolyase family
E5Y90_RS10270	COG0110	maltose O-acetyltransferase activity
E5Y90_RS10290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5Y90_RS10315	COG0564	pseudouridine synthase activity
E5Y90_RS10325	COG0358	DNA primase activity
E5Y90_RS10340	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5Y90_RS10370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5Y90_RS10375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5Y90_RS10420	COG0586	Pfam SNARE associated Golgi protein
E5Y90_RS10445	COG2921	Belongs to the UPF0250 family
E5Y90_RS10450	COG0321	lipoyl(octanoyl) transferase activity
E5Y90_RS10465	COG0531	amino acid
E5Y90_RS10475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5Y90_RS10480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5Y90_RS10480	COG1648	precorrin-2 dehydrogenase activity
E5Y90_RS10485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5Y90_RS10500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5Y90_RS10510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5Y90_RS10525	COG0671	phosphoesterase, PA-phosphatase related
E5Y90_RS10530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_RS10540	COG1538	Outer membrane efflux protein
E5Y90_RS10545	COG0393	Putative heavy-metal-binding
E5Y90_RS10550	COG0393	Putative heavy-metal-binding
E5Y90_RS10605	COG4681	YaeQ
E5Y90_RS10610	COG0523	cobalamin synthesis protein
E5Y90_RS10625	COG0583	DNA-binding transcription factor activity
E5Y90_RS10630	COG2814	Major facilitator Superfamily
E5Y90_RS10640	COG1607	acyl-coa hydrolase
E5Y90_RS10650	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5Y90_RS10660	COG0786	glutamate:sodium symporter activity
E5Y90_RS10670	COG2814	Major facilitator Superfamily
E5Y90_RS10675	COG1289	transmembrane transporter activity
E5Y90_RS10685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5Y90_RS10745	COG2832	Protein of unknown function (DUF454)
E5Y90_RS10770	COG0643	Histidine kinase
E5Y90_RS10770	COG0784	Response regulator, receiver
E5Y90_RS10770	COG2198	Histidine kinase
E5Y90_RS10775	COG0840	transmembrane signaling receptor activity
E5Y90_RS10800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5Y90_RS10845	COG2358	TRAP transporter, solute receptor (TAXI family
E5Y90_RS10860	COG0489	protein tyrosine kinase activity
E5Y90_RS10870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Y90_RS10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5Y90_RS10890	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E5Y90_RS10895	COG2081	HI0933 family
E5Y90_RS10910	COG0668	transmembrane transport
E5Y90_RS10930	COG0583	DNA-binding transcription factor activity
E5Y90_RS10935	COG1278	Cold shock
E5Y90_RS10950	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5Y90_RS10960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Y90_RS10965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5Y90_RS10970	COG0713	ATP synthesis coupled electron transport
E5Y90_RS10975	COG0839	Belongs to the complex I subunit 6 family
E5Y90_RS10980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Y90_RS10995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5Y90_RS11015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5Y90_RS11025	COG2205	protein histidine kinase activity
E5Y90_RS11030	COG0745	RESPONSE REGULATOR receiver
E5Y90_RS11035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5Y90_RS11035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5Y90_RS11040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5Y90_RS11085	COG0352	thiamine-phosphate diphosphorylase activity
E5Y90_RS11085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5Y90_RS11085	COG0351	phosphomethylpyrimidine kinase
E5Y90_RS11090	COG2824	Alkylphosphonate utilization operon protein PhnA
E5Y90_RS11105	COG0564	pseudouridine synthase activity
E5Y90_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS11145	COG2610	gluconate transmembrane transporter activity
E5Y90_RS11155	COG0354	folic acid binding
E5Y90_RS11165	COG0679	Auxin Efflux Carrier
E5Y90_RS11170	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_RS11180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5Y90_RS11185	COG1970	mechanosensitive ion channel activity
E5Y90_RS11195	COG2233	PERMEase
E5Y90_RS11205	COG0833	amino acid
E5Y90_RS11225	COG0183	Belongs to the thiolase family
E5Y90_RS11240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5Y90_RS11250	COG2207	Transcriptional regulator
E5Y90_RS11255	COG0183	Belongs to the thiolase family
E5Y90_RS11260	COG1024	Enoyl-CoA hydratase
E5Y90_RS11260	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5Y90_RS11270	COG2153	protein acetylation
E5Y90_RS11280	COG1272	protein, Hemolysin III
E5Y90_RS11285	COG0477	Major facilitator Superfamily
E5Y90_RS11295	COG1408	metallophosphoesterase
E5Y90_RS11300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5Y90_RS11310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5Y90_RS11335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5Y90_RS11340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5Y90_RS11345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5Y90_RS11355	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5Y90_RS11360	COG0625	glutathione transferase activity
E5Y90_RS11365	COG2969	positive regulation of protein catabolic process
E5Y90_RS11405	COG2199	diguanylate cyclase activity
E5Y90_RS11410	COG2885	chlorophyll binding
E5Y90_RS11440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5Y90_RS11445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5Y90_RS11460	COG0450	alkyl hydroperoxide reductase
E5Y90_RS11475	COG0285	dihydrofolate synthase activity
E5Y90_RS11480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5Y90_RS11525	COG0037	tRNA processing
E5Y90_RS11535	COG0248	Ppx GppA phosphatase
E5Y90_RS11560	COG0072	phenylalanine-tRNA ligase activity
E5Y90_RS11565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5Y90_RS11595	COG1238	metal cluster binding
E5Y90_RS11605	COG0625	glutathione transferase activity
E5Y90_RS11615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5Y90_RS11635	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_RS11650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5Y90_RS11660	COG1704	LemA family
E5Y90_RS11670	COG1862	Preprotein translocase
E5Y90_RS11680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5Y90_RS11695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5Y90_RS11715	COG5002	protein histidine kinase activity
E5Y90_RS11715	COG0784	Response regulator, receiver
E5Y90_RS11715	COG2205	protein histidine kinase activity
E5Y90_RS11725	COG2084	Dehydrogenase
E5Y90_RS11730	COG3622	Belongs to the hyi family
E5Y90_RS11765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5Y90_RS11770	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS11775	COG2072	flavoprotein involved in K transport
E5Y90_RS11780	COG0203	ribosomal protein L17
E5Y90_RS11790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5Y90_RS11825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5Y90_RS11835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5Y90_RS11840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5Y90_RS11845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5Y90_RS11875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5Y90_RS11890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5Y90_RS11900	COG0089	rRNA binding
E5Y90_RS11905	COG0088	Forms part of the polypeptide exit tunnel
E5Y90_RS11910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5Y90_RS11935	COG1959	2 iron, 2 sulfur cluster binding
E5Y90_RS11955	COG1301	dicarboxylic acid transport
E5Y90_RS11960	COG1946	Acyl-CoA thioesterase
E5Y90_RS11965	COG2937	Belongs to the GPAT DAPAT family
E5Y90_RS11975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5Y90_RS11980	COG1040	competence protein
E5Y90_RS11985	COG0494	nUDIX hydrolase
E5Y90_RS11995	COG0598	Magnesium transport protein CorA
E5Y90_RS12005	COG2854	intermembrane phospholipid transfer
E5Y90_RS12010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5Y90_RS12015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5Y90_RS12020	COG1127	ABC transporter
E5Y90_RS12035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5Y90_RS12045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Y90_RS12050	COG0408	coproporphyrinogen oxidase activity
E5Y90_RS12065	COG1960	acyl-CoA dehydrogenase activity
E5Y90_RS12075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5Y90_RS12085	COG0534	Mate efflux family protein
E5Y90_RS12095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5Y90_RS12100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Y90_RS12130	COG1192	Involved in chromosome partitioning
E5Y90_RS12135	COG0628	permease
E5Y90_RS12145	COG2814	Major facilitator Superfamily
E5Y90_RS12165	COG0277	FAD linked oxidase domain protein
E5Y90_RS12170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5Y90_RS12180	COG5006	permease, DMT superfamily
E5Y90_RS12195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5Y90_RS12200	COG5380	lipid catabolic process
E5Y90_RS12205	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E5Y90_RS12220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5Y90_RS12225	COG0228	four-way junction DNA binding
E5Y90_RS12270	COG0194	GDP metabolic process
E5Y90_RS12275	COG1758	RNA polymerase activity
E5Y90_RS12280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5Y90_RS12300	COG3307	-O-antigen
E5Y90_RS12305	COG3307	-O-antigen
E5Y90_RS12395	COG1704	LemA family
E5Y90_RS12405	COG0493	'glutamate synthase
E5Y90_RS12410	COG0069	glutamate synthase activity
E5Y90_RS12410	COG0067	glutamate synthase
E5Y90_RS12410	COG0070	glutamate synthase
E5Y90_RS12460	COG2226	methyltransferase
E5Y90_RS12465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5Y90_RS12470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5Y90_RS12475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5Y90_RS12495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5Y90_RS12525	COG0488	(ABC) transporter
E5Y90_RS12535	COG4221	oxidoreductase activity
E5Y90_RS12540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5Y90_RS12555	COG2111	Na H antiporter
E5Y90_RS12555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5Y90_RS12560	COG1006	Multisubunit Na H antiporter MnhC subunit
E5Y90_RS12565	COG0651	ATP synthesis coupled electron transport
E5Y90_RS12570	COG1863	multisubunit Na H antiporter MnhE subunit
E5Y90_RS12575	COG2212	antiporter activity
E5Y90_RS12585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5Y90_RS12595	COG0195	Participates in both transcription termination and antitermination
E5Y90_RS12635	COG0149	triose-phosphate isomerase activity
E5Y90_RS12655	COG0237	dephospho-CoA kinase activity
E5Y90_RS12665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5Y90_RS12670	COG3123	guanosine phosphorylase activity
E5Y90_RS12675	COG0497	DNA recombination
E5Y90_RS12685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5Y90_RS12695	COG1132	(ABC) transporter
E5Y90_RS12715	COG1538	Outer membrane efflux protein
E5Y90_RS12730	COG0494	nUDIX hydrolase
E5Y90_RS12740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5Y90_RS12745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5Y90_RS12755	COG0772	Belongs to the SEDS family
E5Y90_RS12780	COG4974	Belongs to the 'phage' integrase family
E5Y90_RS12785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5Y90_RS12795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5Y90_RS12805	COG2197	response regulator
E5Y90_RS12810	COG4191	Histidine kinase
E5Y90_RS12820	COG0793	Belongs to the peptidase S41A family
E5Y90_RS12825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5Y90_RS12830	COG0795	lipopolysaccharide-transporting ATPase activity
E5Y90_RS12835	COG0795	lipopolysaccharide-transporting ATPase activity
E5Y90_RS12855	COG0586	Pfam SNARE associated Golgi protein
E5Y90_RS12870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5Y90_RS12870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5Y90_RS12880	COG0004	ammonium transporteR
E5Y90_RS12885	COG0347	Belongs to the P(II) protein family
E5Y90_RS12895	COG0606	chelatase, subunit chli
E5Y90_RS12910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5Y90_RS12925	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_RS12935	COG0477	Major facilitator Superfamily
E5Y90_RS12940	COG2860	membrane
E5Y90_RS12950	COG1253	flavin adenine dinucleotide binding
E5Y90_RS12965	COG0477	Major facilitator Superfamily
E5Y90_RS12975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5Y90_RS12995	COG2814	Major facilitator Superfamily
E5Y90_RS13045	COG0758	DNA mediated transformation
E5Y90_RS13055	COG0697	spore germination
E5Y90_RS13070	COG0386	Belongs to the glutathione peroxidase family
E5Y90_RS13095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5Y90_RS13145	COG1121	(ABC) transporter
E5Y90_RS13150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5Y90_RS13155	COG1683	Conserved Protein
E5Y90_RS13170	COG2837	iron assimilation
E5Y90_RS13180	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E5Y90_RS13230	COG0629	single-stranded DNA binding
E5Y90_RS13235	COG2814	Major facilitator Superfamily
E5Y90_RS13245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5Y90_RS13245	COG0352	thiamine-phosphate diphosphorylase activity
E5Y90_RS13245	COG0351	phosphomethylpyrimidine kinase
E5Y90_RS13255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5Y90_RS13270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5Y90_RS13280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5Y90_RS13285	COG3162	membrane
E5Y90_RS13290	COG2205	protein histidine kinase activity
E5Y90_RS13290	COG0784	Response regulator, receiver
E5Y90_RS13305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5Y90_RS13315	COG0668	transmembrane transport
E5Y90_RS13320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5Y90_RS13325	COG1519	Transferase
E5Y90_RS13330	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_RS13360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5Y90_RS13385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5Y90_RS13385	COG0426	domain, Protein
E5Y90_RS13390	COG2119	membrane
E5Y90_RS13405	COG4942	peptidase
E5Y90_RS13430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5Y90_RS13440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5Y90_RS13450	COG0189	ligase activity
E5Y90_RS13465	COG2132	Multicopper oxidase
E5Y90_RS13490	COG4689	acetoacetate decarboxylase
E5Y90_RS13495	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5Y90_RS13495	COG1902	pentaerythritol trinitrate reductase activity
E5Y90_RS13505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5Y90_RS13510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5Y90_RS13525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5Y90_RS13535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5Y90_RS13545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5Y90_RS13550	COG0438	transferase activity, transferring glycosyl groups
E5Y90_RS13565	COG0438	transferase activity, transferring glycosyl groups
E5Y90_RS13580	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5Y90_RS13625	COG1194	a g-specific adenine glycosylase
E5Y90_RS13630	COG0739	heme binding
E5Y90_RS13655	COG2818	Glycosylase
E5Y90_RS13660	COG1064	alcohol dehydrogenase
E5Y90_RS13670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5Y90_RS13715	COG3830	Belongs to the UPF0237 family
E5Y90_RS13715	COG0560	Phosphoserine phosphatase
E5Y90_RS13725	COG0385	Bile acid
E5Y90_RS13730	COG1335	isochorismatase
E5Y90_RS13735	COG2814	Major facilitator Superfamily
E5Y90_RS13740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5Y90_RS13750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5Y90_RS13755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5Y90_RS13765	COG2983	Belongs to the UPF0260 family
E5Y90_RS13770	COG5487	UPF0391 membrane protein
E5Y90_RS13780	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5Y90_RS13795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5Y90_RS13800	COG1309	transcriptional regulator
E5Y90_RS13805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5Y90_RS13810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5Y90_RS13815	COG0546	phosphoglycolate phosphatase activity
E5Y90_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS13845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5Y90_RS13845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5Y90_RS13850	COG1309	transcriptional regulator
E5Y90_RS13860	COG0196	riboflavin kinase activity
E5Y90_RS13865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5Y90_RS13875	COG1047	Peptidyl-prolyl cis-trans
E5Y90_RS13885	COG2133	pyrroloquinoline quinone binding
E5Y90_RS13915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5Y90_RS13920	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5Y90_RS13925	COG2951	lytic endotransglycosylase activity
E5Y90_RS13930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5Y90_RS13945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5Y90_RS13955	COG2814	Major facilitator Superfamily
E5Y90_RS13960	COG0861	Integral membrane protein TerC family
E5Y90_RS13965	COG0402	S-adenosylhomocysteine deaminase activity
E5Y90_RS13980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5Y90_RS13995	COG0706	membrane insertase activity
E5Y90_RS14000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5Y90_RS14005	COG0594	ribonuclease P activity
E5Y90_RS14035	COG1024	Enoyl-CoA hydratase
E5Y90_RS14050	COG0318	PFAM AMP-dependent synthetase and ligase
E5Y90_RS14375	COG0629	single-stranded DNA binding
E5Y90_RS14410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5Y90_RS14605	COG1309	transcriptional regulator
E5Y90_RS14960	COG3550	peptidyl-serine autophosphorylation
E5Y90_RS15255	COG0739	heme binding
E5Y90_RS15440	COG0501	Belongs to the peptidase M48B family
E5Y90_RS15450	COG1309	transcriptional regulator
E5Y90_RS15470	COG1028	Short-chain dehydrogenase reductase Sdr
E5Y90_RS15630	COG5265	(ABC) transporter
E5Y90_RS15680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5Y90_RS15705	COG0754	glutathionylspermidine amidase activity
E5Y90_RS15795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5Y90_RS15805	COG1525	nuclease
E5Y90_RS15935	COG1484	DNA-dependent DNA replication
E5Y90_RS15990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_RS16000	COG2610	gluconate transmembrane transporter activity
E5Y90_RS16005	COG1454	alcohol dehydrogenase
E5Y90_RS16015	COG1414	Transcriptional regulator
E5Y90_RS16065	COG1373	ATPase (AAA superfamily
E5Y90_RS16140	COG1012	belongs to the aldehyde dehydrogenase family
E5Y90_RS16160	COG3077	Addiction module antitoxin, RelB DinJ family
E5Y90_RS16185	COG1414	Transcriptional regulator
E5Y90_RS16215	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E5Y90_RS16315	COG2801	Transposase and inactivated derivatives
E5Y90_RS16340	COG4680	protein conserved in bacteria
E5Y90_RS16370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_RS16405	COG0789	Transcriptional regulator
E5Y90_RS16430	COG0582	viral genome integration into host DNA
E5Y90_RS16435	COG2369	cell adhesion
E5Y90_RS16455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5Y90_RS16515	COG4372	Transposase
E5Y90_RS16635	COG2963	transposase activity
E5Y90_RS16640	COG1475	DNA binding
E5Y90_RS16645	COG1192	Involved in chromosome partitioning
E5Y90_RS16660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_RS16755	COG2184	nucleotidyltransferase activity
E5Y90_RS16785	COG1475	DNA binding
E5Y90_RS16790	COG1192	Involved in chromosome partitioning
E5Y90_RS16835	COG0745	RESPONSE REGULATOR receiver
E5Y90_RS16840	COG5002	protein histidine kinase activity
E5Y90_RS16850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5Y90_RS16905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5Y90_RS16950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5Y90_RS16965	COG1335	isochorismatase
E5Y90_RS16970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5Y90_RS16990	COG0753	catalase activity
E5Y90_RS17000	COG0753	catalase activity
E5Y90_RS17055	COG0583	DNA-binding transcription factor activity
E5Y90_RS17075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5Y90_RS17080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5Y90_RS17090	COG0659	secondary active sulfate transmembrane transporter activity
E5Y90_RS17140	COG2944	sequence-specific DNA binding
E5Y90_RS17200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5Y90_RS17245	COG2076	Multidrug Resistance protein
E5Y90_RS17255	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E5Y90_RS17280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD